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274 results on '"Mikata, Rintaro"'

3. Diagnostic value of peroral cholangioscopy in addition to computed tomography for indeterminate biliary strictures

Author

Shima, Yukiko, Sugiyama, Harutoshi, Ogasawara, Sadahisa, Kan, Motoyasu, Maruta, Shikiko, Yamada, Toshihito, Miura, Yoshifumi, Asano, Kosho, Sensui, Miyuki, Nagashima, Hiroki, Yokoyama, Masayuki, Kusakabe, Yuko, Yasui, Shin, Ohno, Izumi, Mikata, Rintaro, Tsuyuguchi, Toshio, Horikoshi, Takuro, Mishima, Takashi, Kuboki, Satoshi, Takayashiki, Tsukasa, Ohtsuka, Masayuki, Kato, Jun, and Kato, Naoya

Published
2022
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7. “Salvage techniques” are the key to overcome difficult biliary cannulation in endoscopic retrograde cholangiopancreatography

Author

Maruta, Shikiko, Sugiyama, Harutoshi, Ogasawara, Sadahisa, Sugihara, Chihei, Ouchi, Mayu, Kan, Motoyasu, Yamada, Toshihito, Miura, Yoshifumi, Nagashima, Hiroki, Takahashi, Koji, Kusakabe, Yuko, Ohyama, Hiroshi, Okitsu, Koichiro, Ohno, Izumi, Mikata, Rintaro, Sakai, Yuji, Tsuyuguchi, Toshio, Kato, Jun, and Kato, Naoya

Published
2022
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8. Analysis of circulating cell-free DNA after endoscopic ultrasound-guided fine needle aspiration in pancreatic ductal adenocarcinoma

Author

Asano, Kosho, Mikata, Rintaro, Chiba, Tetsuhiro, Kan, Motoyasu, Maruta, Shikiko, Yamada, Toshihito, Miura, Yoshifumi, Shima, Yukiko, Sensui, Miyuki, Nagashima, Hiroki, Yokoyama, Masayuki, Ohyama, Hiroshi, Kusakabe, Yuko, Yasui, Shin, Sugiyama, Harutoshi, Ohno, Izumi, Kato, Jun, Takano, Shigetsugu, Ohtsuka, Masayuki, and Kato, Naoya

Published
2021
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10. The efficacy of bile liquid biopsy in the diagnosis and treatment of biliary tract cancer.

Author

Miura, Yoshifumi, Ohyama, Hiroshi, Mikata, Rintaro, Hirotsu, Yosuke, Amemiya, Kenji, Mochizuki, Hitoshi, Ikeda, Junichiro, Ohtsuka, Masayuki, Kato, Naoya, and Omata, Masao

Abstract

Background: Diagnosing biliary tract cancer is difficult because endoscopic retrograde cholangiopancreatography (ERCP) is performed fluoroscopically, and the sensitivity of bile cytology is low. Liquid biopsy of bile using targeted sequencing is expected to improve diagnosis and treatment, but few studies have been conducted. In this study, we examined whether liquid biopsy of bile improves the diagnostic sensitivity of biliary strictures. Methods: A total of 72 patients with biliary strictures who underwent ERCP at Chiba University Hospital between April 2018 and March 2021 were examined. Of these, 43 and 29 were clinically and pathologically diagnosed as having malignant and benign biliary strictures, respectively. We performed targeted sequencing of bile obtained from these patients, and the sensitivity of this method was compared with that of bile cytology. Detection of at least one oncogenic mutation was defined as having malignancy. Results: The sensitivity of bile cytology was 27.9%, whereas that of genomic analysis was 46.5%. Comparing bile cytology alone with the combination of cytology and genomic analysis, the latter was more sensitive (53.5%, p <.001). Among the 43 patients with malignant biliary strictures, mutations with FDA‐approved drugs were detected in 11 (26%). Conclusions: Liquid biopsy of bile can potentially diagnose malignancy and detect therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Development of a molecular barcode detection system for pancreaticobiliary malignancies and comparison with next-generation sequencing

Author

Ohyama, Hiroshi, primary, Hirotsu, Yosuke, additional, Amemiya, Kenji, additional, Mikata, Rintaro, additional, Amano, Hiroyuki, additional, Hirose, Sumio, additional, Oyama, Toshio, additional, Iimuro, Yuji, additional, Kojima, Yuichiro, additional, Mochizuki, Hitoshi, additional, Kato, Naoya, additional, and Omata, Masao, additional

Published
2023
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13. EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma

Author

Kusakabe, Yuko, Chiba, Tetsuhiro, Oshima, Motohiko, Koide, Shuhei, Rizq, Ola, Aoyama, Kazumasa, Ao, Junjie, Kaneko, Tatsuya, Kanzaki, Hiroaki, Kanayama, Kengo, Maeda, Takahiro, Saito, Tomoko, Nakagawa, Ryo, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Ogasawara, Sadahisa, Suzuki, Eiichiro, Nakamoto, Shingo, Yasui, Shin, Mikata, Rintaro, Muroyama, Ryosuke, Kanda, Tatsuo, Maruyama, Hitoshi, Kato, Jun, Mimura, Naoya, Ma, Anqi, Jin, Jian, Zen, Yoh, Otsuka, Masayuki, Kaneda, Atsushi, Iwama, Atsushi, and Kato, Naoya

Published
2021
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16. Needle tract seeding recurrence of pancreatic cancer in the gastric wall with paragastric lymph node metastasis after endoscopic ultrasound-guided fine needle aspiration followed by pancreatectomy: a case report and literature review

Author

Sato, Nami, Takano, Shigetsugu, Yoshitomi, Hideyuki, Furukawa, Katsunori, Takayashiki, Tsukasa, Kuboki, Satoshi, Suzuki, Daisuke, Sakai, Nozomu, Kagawa, Shingo, Mishima, Takashi, Nakadai, Eri, Mikata, Rintaro, Kato, Naoya, and Ohtsuka, Masayuki

Published
2020
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20. Comparison of genomic profiling of circulating tumor DNA in pancreaticobiliary malignancies in plasma and bile

Author

Ohyama, Hiroshi, primary, Hirotsu, Yosuke, additional, Amemiya, Kenji, additional, Miura, Yoshifumi, additional, Hirose, Sumio, additional, Oyama, Toshio, additional, Iimuro, Yuji, additional, Kojima, Yuichiro, additional, Mikata, Rintaro, additional, Mochizuki, Hitoshi, additional, Kato, Naoya, additional, and Omata, Masao, additional

Published
2023
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21. Diffusion-Weighted Magnetic Resonance Imaging and 18-Fluorodeoxglucose Positron Emission Tomography With Computed Tomography for Evaluating Malignancy of Branch Duct and Mixed Type Intraductal Papillary Mucinous Neoplasms of the Pancreas

Author

Hayashi, Masahiro, Mikata, Rintaro, Horikoshi, Takuro, Senoo, Jyunichi, Kusakabe, Yuko, Ohyama, Hiroshi, Yasui, Shin, Uchida, Yoshitaka, Uchiyama, Katsuhiro, Kishimoto, Takashi, Yoshitomi, Hideyuki, Ohtsuka, Masayuki, Tsuyuguchi, Toshio, and Kato, Naoya

Published
2019
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25. Tu1182: IMPACT OF MYCOBIOME IN PANCREATIC CANCER PATIENTS

Author

Yamada, Toshihito, primary, Ohno, Izumi, additional, Goto, Yoshiyuki, additional, Taida, Takashi, additional, Sugihara, Chihei, additional, Nakagawa, Ryo, additional, Ouchi, Mayu, additional, Kan, Motoyasu, additional, Maruta, Shikiko, additional, Miura, Yoshifumi, additional, Nagashima, Hiroki, additional, Takahashi, Koji, additional, Ohyama, Hiroshi, additional, Kusakabe, Yuko, additional, Okitsu, Kohichiroh, additional, Sugiyama, Harutoshi, additional, Mikata, Rintaro, additional, Chiba, Tetsuhiro, additional, Ohtsuka, Masayuki, additional, and Kato, Naoya, additional

Published
2022
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26. EP1182: PATHOGENESIS OF PRIMARY SCLEROSING CHOLANGITIS BY BILE PROTEOME ANALYSIS USING HIGH-PRECISION MASS SPECTROMETRY

Author

Kan, Motoyasu, primary, Chiba, Tetsuhiro, additional, Konno, Ryo, additional, Kawashima, Yusuke, additional, Ogawa, Keita, additional, Iwanaga, Terunao, additional, Sakuma, Takafumi, additional, Ao, Junjie, additional, Qiang, Na, additional, Ma, Yaojia, additional, Zhang, Jiaqi, additional, Miura, Yoshifumi, additional, Kojima, Ryuta, additional, Nagashima, Hiroki, additional, Takahashi, Koji, additional, Kusakabe, Yuko, additional, Nakamura, Masato, additional, Ohyama, Hiroshi, additional, Sugiyama, Haretoshi, additional, Ohno, Izumi, additional, Mikata, Rintaro, additional, Ohara, Osamu, additional, and Kato, Naoya, additional

Published
2022
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31. Salvage Techniques for Difficult Biliary Cannulation: A Retrospective Study of 1021 Endoscopic Retrograde Cholangiopancreatography Cases in a Tertiary Referral Center

Author

Maruta, Shikiko, primary, Sugiyama, Harutoshi, additional, Ogasawara, Sadahisa, additional, Sugihara, Chihei, additional, Ouchi, Mayu, additional, Kan, Motoyasu, additional, Yamada, Toshihito, additional, Miura, Yoshifumi, additional, Nagashima, Hiroki, additional, Takahashi, Koji, additional, Kusakabe, Yuko, additional, Ohyama, Hiroshi, additional, Okitsu, Koichiro, additional, Ohno, Izumi, additional, Mikata, Rintaro, additional, Sakai, Yuji, additional, Tsuyuguchi, Toshio, additional, Kato, Jun, additional, and Kato, Naoya, additional

Published
2021
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33. Needle tract seeding after endoscopic ultrasound‐guided tissue acquisition of pancreatic tumors: Nationwide survey in Japan.

Author

Kitano, Masayuki, Yoshida, Makoto, Ashida, Reiko, Kita, Emiri, Katanuma, Akio, Itoi, Takao, Mikata, Rintaro, Nishikawa, Kenichiro, Matsubayashi, Hiroyuki, Takayama, Yukiko, Kato, Hironari, Takenaka, Mamoru, Ueki, Toru, Kawashima, Yohei, Nakai, Yousuke, Hashimoto, Shinichi, Shigekawa, Minoru, Nebiki, Hiroko, Tsumura, Hidetaka, and Okabe, Yosinobu

Subjects
PANCREATIC tumors, OVERALL survival, PANCREATIC duct, SURGICAL excision, SURVIVAL rate, PANCREAS, SOWING
Abstract

Objectives: Endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) plays a crucial role in the diagnosis of pancreatic tumors. The present study aimed to investigate the current status of needle tract seeding (NTS) after EUS‐TA of pancreatic tumors based on a nationwide survey in Japan. Methods: Patients who underwent surgical resection of primary pancreatic tumors after EUS‐TA performed between April 2010 and March 2018 were surveyed. The incidence rates of NTS were determined, and compared in patients with pancreatic ductal adenocarcinomas (PDACs) and other tumors, and in patients who underwent transgastric and transduodenal EUS‐TA of PDACs. The detailed features and prognosis of patients with NTS were also assessed. Results: A total of 12,109 patients underwent surgical resection of primary pancreatic tumors after EUS‐TA. The overall incidence rate of NTS was 0.330%, and the NTS rate was significantly higher in patients with PDAC than in those with other tumors (0.409% vs. 0.071%, P = 0.004). NTS was observed in 0.857% of patients who underwent transgastric EUS‐TA, but in none of those who underwent transduodenal EUS‐TA. Of the patients with NTS of PDACs, the median time from EUS‐TA to occurrence of NTS and median patient survival were 19.3 and 44.7 months, respectively, with 97.4% of NTS located in the gastric wall and 65.8% of NTS resected. The patient survival was significantly longer in patients who underwent NTS resection than in those without NTS resection (P = 0.037). Conclusions: Needle tract seeding appeared only after transgastric not after transduodenal EUS‐TA. Careful follow‐up provides an opportunity to remove localized NTS lesions by gastrectomy. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Diagnostic value of peroral cholangioscopy in addition to computed tomography for indeterminate biliary strictures

Author

Shima, Yukiko, primary, Sugiyama, Harutoshi, additional, Ogasawara, Sadahisa, additional, Kan, Motoyasu, additional, Maruta, Shikiko, additional, Yamada, Toshihito, additional, Miura, Yoshifumi, additional, Asano, Kosho, additional, Sensui, Miyuki, additional, Nagashima, Hiroki, additional, Yokoyama, Masayuki, additional, Kusakabe, Yuko, additional, Yasui, Shin, additional, Ohno, Izumi, additional, Mikata, Rintaro, additional, Tsuyuguchi, Toshio, additional, Horikoshi, Takuro, additional, Mishima, Takashi, additional, Kuboki, Satoshi, additional, Takayashiki, Tsukasa, additional, Ohtsuka, Masayuki, additional, Kato, Jun, additional, and Kato, Naoya, additional

Published
2021
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45. Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor

Author

Iino, Yotaro, primary, Maruyama, Hitoshi, additional, Mikata, Rintaro, additional, Yasui, Shin, additional, Koroki, Keisuke, additional, Nagashima, Hiroki, additional, Awatsu, Masami, additional, Shingyoji, Ayako, additional, Kusakabe, Yuko, additional, Kobayashi, Kazufumi, additional, Kiyono, Soichiro, additional, Nakamura, Masato, additional, Ohyama, Hiroshi, additional, Sugiyama, Harutoshi, additional, Sakai, Yuji, additional, Chiba, Tetsuhiro, additional, Kato, Jun, additional, Tsuyuguchi, Toshio, additional, and Kato, Naoya, additional

Published
2021
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46. Phase II study comparing nasal pressure monitoring with capnography during invasive endoscopic procedures: a single-center, single-arm trial.

Author

Nagashima, Hiroki, Mikata, Rintaro, Isono, Shiroh, Ogasawara, Sadahisa, Sugiyama, Harutoshi, Ohno, Izumi, Yasui, Shin, Matsumura, Tomoaki, Koroki, Keisuke, Kusakabe, Yuko, Miura, Yoshifumi, Kan, Motoyasu, Maruta, Shikiko, Yamada, Toshihito, Takemura, Ryo, Sato, Yasunori, Kato, Jun, and Kato, Naoya

Subjects
*CAPNOGRAPHY, *SLEEP apnea syndromes, *VENTILATION monitoring, *FALSE alarms, *VENTILATION, *PRESSURE
Abstract

Nasal pressure signal is commonly used to evaluate obstructive sleep apnea. This study aimed to assess its safety for respiratory monitoring during sedation. A total of 45 adult patients undergoing sedation with propofol and fentanyl for invasive endoscopic procedures were enrolled. While both nasal pressure and capnograph signals were continuously recorded, only the nasal pressure signal was displayed. The primary outcome was the incidence of oxygen desaturation below 90%. The secondary outcomes were the ability to predict the desaturation and incidence of harmful events and false alarms, defined as an apnea waveform lasting more than 3 min without desaturation. Of the 45 participants, 43 completed the study. At least one desaturation event occurred in 12 patients (27.9%; 95% confidence interval 15.3–43.7%). In these 12 patients, more than half of the desaturation events were predictable in 9 patients by capnography and 11 patients by nasal pressure monitoring (p = 0.59). In the 43 patients, false alarms were detected in 7 patients with capnography and 11 patients with nasal pressure monitoring (p = 0.427). Harmful events unrelated to nasal pressure monitoring occurred in 2 patients. Nasal pressure monitoring is safe and possibly useful for respiratory monitoring despite false alarms during sedation. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Diverse transitions in diabetes status during the clinical course of patients with resectable pancreatic cancer

Author

Shingyoji, Ayako, primary, Mikata, Rintaro, additional, Ogasawara, Sadahisa, additional, Kusakabe, Yuko, additional, Yasui, Shin, additional, Sugiyama, Harutoshi, additional, Ohno, Izumi, additional, Kato, Jun, additional, Takano, Shigetsugu, additional, Yoshitomi, Hideyuki, additional, Ohtsuka, Masayuki, additional, and Kato, Naoya, additional

Published
2020
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