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Standardized monitoring of BCR::ABL1 mRNA levels is essential for the management of chronic myeloid leukemia (CML) patients. From 2016 to 2021 the European Treatment and Outcome Study for CML (EUTOS) explored the use of secondary, lyophilized cell-based BCR::ABL1 reference panels traceable to the World Health Organization primary reference material to standardize and validate local laboratory tests. Panels were used to assign and validate conversion factors (CFs) to the International Scale and assess the ability of laboratories to assess deep molecular response (DMR). The study also explored aspects of internal quality control. The percentage of EUTOS reference laboratories (n = 50) with CFs validated as optimal or satisfactory increased from 67.5% to 97.6% and 36.4% to 91.7% for ABL1 and GUSB, respectively, during the study period and 98% of laboratories were able to detect MR4.5 in most samples. Laboratories with unvalidated CFs had a higher coefficient of variation for BCR::ABL1IS and some laboratories had a limit of blank greater than zero which could affect the accurate reporting of DMR. Our study indicates that secondary reference panels can be used effectively to obtain and validate CFs in a manner equivalent to sample exchange and can also be used to monitor additional aspects of quality assurance.

The purpose of this paper is to identify and quantify the economic, technological and legislative factors of mineral resources and create a model for the rational use of mineral resources. The rationality is to be understood in the context of its possible applications in terms of the owner of the mineral resources and the state mining company, and the regional impacts which significantly affects the development of cities in the region). Raw materials are an essential resource for the development of an industrial infrastructure in the region. Their price and the availability of technology determine the level of cost incurred in the construction, which is directly linked to the efficiency of investment. Rational utilisation and maintaining sustainable development of the limited and non-renewable raw materials is an objective during creating the Raw Materials Policy in the region. Analysis and synthesis are used at all stages of problem solving in the work. Analysis of a thought process of breaking down the problem studied into smaller parts, elements, characters to reveal their essence. For large amounts of data and context aims to allocate capital, essential that illuminates the essence of the entire studied event and its causes. Models, which are located in this paper resulting directly applicable and acceptable in legislative decision-making on utilization of mineral resources in terms of development of the region. A limiting factor in the decision making process is to identify political risk services, resulting from the possibility of changes in legislation due to social acceptance wishes to achieve political maximize profitability. Originality of the paper is in the progressive approach to solving the problems of managing the use of mineral resources in the context of regional development. It is absolutely fresh look and long-awaited tool for objective assessment of the importance of mineral resources when deciding on regional development acceptable from the standpoint of the state.

The paper deals with the most important processes used for treatment of blast furnace and steelmaking slags and with the most important ways of their utilization. The method of recycling of steelmaking slags that followed from own experiments of the authors, are described. Proposal for way of utilization of one sort of ladle furnace slag is also included.

Book of abstracts of the 12th International Symposium of Croatian Metallurgical Society held in Šibenik, Croatia, June 19-23, 2016. The proceedings is organized in 5 sections: Plenary lectures ; Materials – Section "A" ; Process Metallurgy – Section "B" ; Plastic Processing - Section "C" ; Metallurgy and Related Topics – Section "D".

Book of abstracts of the 6th International Symposium of Croatian Metallurgical Society held in Šibenik, Croatia, June 20-24, 2004. The proceedings is organized in 5 sections: Plenary lectures ; Materials – Section "A" ; Process Metallurgy – Section "B" ; Plastic Processing - Section "C" ; Metallurgy and Related Topics – Section "D".

Book of abstracts of the 5th International Symposium of Croatian Metallurgical Society held in Šibenik, Croatia, June 23-27, 2002. The proceedings is organized in 5 sections: Plenary lectures ; Materials – Section "A" ; Process Metallurgy – Section "B" ; Plastic Processing - Section "C" ; Metallurgy and Related Topics – Section "D".

The lecture show first all technologies for plastic forming of metals and alloys: rolling, forging, cold deformations etc.Important also authors give new directions and research of plastic forming in the World. Specially development in production of tubes.