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3. Kampo diagnostic ability is specific in post‐clinical clerkship objective structured clinical examination: An observational study.

Author

Mihara, Hiroshi, Watari, Hidetoshi, Fujimoto, Makoto, Kainuma, Mosaburo, and Takamura, Akiteru

Subjects
*MEDICAL students, *FACTOR analysis, *MEDICAL logic, *REQUIRED courses (Education), JAPANESE herbal medicine
Abstract

Background: The Japanese medical educational model core curriculum requires an understanding of the characteristics of Kampo medicine. However, there are few reports on the methods of evaluating the skill levels of Kampo medicine practitioners. Objective: This study investigated the utility of objective structured clinical examination (OSCE) for evaluating the skills of Kampo medicine practitioners, exploring its relationship with other medical skills. Methods: The 2022 post‐clinical clerkship OSCE assessed the accuracy of Kampo‐related tasks, specifically abdominal examinations. In addition, correlation coefficients and factor analysis were used to analyze the relationship of Kampo tasks with other tasks (three clinical‐reasoning tasks, electrocardiogram attachment task, joint examination task). Results: Medical students showed significant variation in their ability to accurately assess different abdominal regions. The epigastric region had the highest accuracy (92.0%), while the para‐umbilical region had the lowest (45.1%). Correlation analysis between Kampo tasks and other clinical tasks (clinical reasoning, electrocardiogram attachment, joint examination) yielded coefficients ranging from 0.10 to 0.19, suggesting a low relationship. Factor analysis confirmed the independence of Kampo skills from other assessed medical skills across four distinct factors. Conclusions: Since Kampo diagnostic skills are highly unique, it is possible that Western medicine OSCE tasks alone may not sufficiently assess competency in Kampo medicine. Therefore, it is necessary to consider incorporating Kampo tasks into the OSCE. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Evidence-based clinical practice guidelines for functional dyspepsia 2021

Author

Miwa, Hiroto, Nagahara, Akihito, Asakawa, Akihiro, Arai, Makoto, Oshima, Tadayuki, Kasugai, Kunio, Kamada, Kazuhiro, Suzuki, Hidekazu, Tanaka, Fumio, Tominaga, Kazunari, Futagami, Seiji, Hojo, Mariko, Mihara, Hiroshi, Higuchi, Kazuhide, Kusano, Motoyasu, Arisawa, Tomiyasu, Kato, Mototsugu, Joh, Takashi, Mochida, Satoshi, Enomoto, Nobuyuki, Shimosegawa, Tooru, and Koike, Kazuhiko

Published
2022
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7. A Novel Contactless SiC Wafer Planarization Processing after Mechanical Slicing by Dynamic Thermal Annealing Processes

Author

Toda, Kohei, Kakutani, Daichi, Dojima, Daichi, Nakajima, Yuta, Mihara, Hiroshi, and Kaneko, Tadaaki

Abstract

In conventional machining of SiC wafers, material loss and sub-surface damage (SSD) of both the front and back surfaces are major issues. In this study, we focused on Dynamic AGE-ing® (DA), which is a sublimation-controlled process, and applied it to the total wafering process without any mechanical contact of both the front and back surfaces to explore the possibilities to reach the CMP-equivalent quality. DA process enables material lossless planarization of SiC wafers by applying a temperature gradient to achieve simultaneous etching and growth at the same rate on one and the other surfaces, respectively. To drive the planarization function for a multi-wire saw finished as-sliced wafer, as an example, a high-temperature regime above 2000 °C under an Ar background pressure higher than 1 kPa to suppress etching and growth rates was employed as the first step in the DA treatment. In this step, an effective annealing function arises where sublimation and recrystallization occur simultaneously through a sub-surface region on both sides of the wafer. Due to the active interchange of the surface and subsurface layer, a self-organizing planarization effect occurs on a macroscopic scale on both surfaces with the removal of SSD. The conventional DA processes were employed for the following microscopic flatness control. As a result, the roughness of the 6-inch as-sliced wafer was reduced to 0.7 nm on the Si-face and 2.0 nm on the C-face while maintaining the wafer thickness. This is the first promising result exhibiting the potential of thermal contactless treatment for next-generation wafer manufacturing by improving quality and cost.

Published
2024
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10. Additional file 3 of Colonic TRPV4 overexpression is related to constipation severity

Author

Mihara, Hiroshi, Uchida, Kunitoshi, Watanabe, Yoshiyuki, Nanjo, Sohachi, Sakumura, Miho, Motoo, Iori, Ando, Takayuki, Minemura, Masami, Muhammad, Jibran Sualeh, Yamamoto, Hiroyuki, Itoh, Fumio, and Yasuda, Ichiro

Abstract

Additional file 3. The original untreated full-length blots of TRPV4, TNFαR2 and βactin are presented with molecular size markers. GES-1 was used as a positive control to confirm that TRPV4 was specifically detected.

Published
2023
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11. Additional file 2 of Colonic TRPV4 overexpression is related to constipation severity

Author

Mihara, Hiroshi, Uchida, Kunitoshi, Watanabe, Yoshiyuki, Nanjo, Sohachi, Sakumura, Miho, Motoo, Iori, Ando, Takayuki, Minemura, Masami, Muhammad, Jibran Sualeh, Yamamoto, Hiroyuki, Itoh, Fumio, and Yasuda, Ichiro

Abstract

Additional file 2. Table S1. Clinical isolates and Standard isolates of Enterobacteriaceae used in this study. Table S2. Primer sequences for qPCR.

Published
2023
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14. Factors, Including Clinical Trial Eligibility, Associated with Induction of Third-Line Treatment for Advanced Gastric Cancer

Author

Ando, Takayuki, primary, Hosokawa, Ayumu, additional, Sakumura, Miho, additional, Motoo, Iori, additional, Kajiura, Shinya, additional, Hirano, Katsuhisa, additional, Miwa, Takeshi, additional, Yokota, Tomotaka, additional, Nakada, Naokatsu, additional, Ueda, Yuko, additional, Ueda, Akira, additional, Tsukada, Kenichiro, additional, Ogawa, Kohei, additional, Nakaya, Atsuko, additional, Teramoto, Akira, additional, Nanjo, Sohachi, additional, Mihara, Hiroshi, additional, Fujinami, Haruka, additional, Fujii, Tsutomu, additional, and Yasuda, Ichiro, additional

Published
2022
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15. The Practice Guidelines for Primary Care of Acute Abdomen 2015

Author

Mayumi, Toshihiko, Yoshida, Masahiro, Tazuma, Susumu, Furukawa, Akira, Nishii, Osamu, Shigematsu, Kunihiro, Azuhata, Takeo, Itakura, Atsuo, Kamei, Seiji, Kondo, Hiroshi, Maeda, Shigenobu, Mihara, Hiroshi, Mizooka, Masafumi, Nishidate, Toshihiko, Obara, Hideaki, Sato, Norio, Takayama, Yuichi, Tsujikawa, Tomoyuki, Fujii, Tomoyuki, Miyata, Tetsuro, Maruyama, Izumi, Honda, Hiroshi, and Hirata, Koichi

Published
2016
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17. Colonic TRPV4 overexpression is related to constipation severity

Author

Mihara, Hiroshi, primary, Uchida, Kunitoshi, additional, Watanabe, Yoshiyuki, additional, Nanjo, Sohachi, additional, Sakumura, Miho, additional, Motoo, Iori, additional, Ando, Takayuki, additional, Minemura, Masami, additional, Muhammad, Jibran Sualeh, additional, Yamamoto, Hiroyuki, additional, Itoh, Fumio, additional, and Yasuda, Ichiro, additional

Published
2022
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24. Suppression of In-Grown SF Formation and BPD Propagation in 4H-Sic Epitaxial Layer by Sublimating Sub-Surface Damage before the Growth

Author

Toda, Kohei, Dojima, Daichi, Kojima, Kiyoshi, Mihara, Hiroshi, Mitani, Shinichi, and Kaneko, Tadaaki

Abstract

It is known that basal plane dislocations (BPDs) and in-grown stacking faults (IGSFs) in the 4H-SiC epitaxial layer cause severe electrical degradation in SiC devices. The impact that sub-surface damage (SSD) on a production-grade 4H-SiC substrate with CMP-finished surface causes on both the BPD propagation and IGSF formation during epitaxial growth was investigated by Dynamic AGE-ing (DA). The substrates etched by DA sublimation etching to adjust the residual amount of SSD maintaining a smooth surface without macro step bunching were grown to observe BPD and IGSF density. The obtained results showed that these defect densities decreased exponentially with increasing etching depth. We demonstrated SSD introduced by mechanical processing led BPDs and IGSFs to extend or introduce to the epitaxial layer.

Published
2023
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25. Practice Guidelines for Primary Care of Acute Abdomen 2015

Author

Mayumi, Toshihiko, Yoshida, Masahiro, Tazuma, Susumu, Furukawa, Akira, Nishii, Osamu, Shigematsu, Kunihiro, Azuhata, Takeo, Itakura, Atsuo, Kamei, Seiji, Kondo, Hiroshi, Maeda, Shigenobu, Mihara, Hiroshi, Mizooka, Masafumi, Nishidate, Toshihiko, Obara, Hideaki, Sato, Norio, Takayama, Yuichi, Tsujikawa, Tomoyuki, Fujii, Tomoyuki, Miyata, Tetsuro, Maruyama, Izumi, Honda, Hiroshi, and Hirata, Koichi

Published
2016
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29. Factors, Including Clinical Trial Eligibility, Associated with Induction of Third-Line Treatment for Advanced Gastric Cancer.

Author

Ando, Takayuki, Hosokawa, Ayumu, Sakumura, Miho, Motoo, Iori, Kajiura, Shinya, Hirano, Katsuhisa, Miwa, Takeshi, Yokota, Tomotaka, Nakada, Naokatsu, Ueda, Yuko, Ueda, Akira, Tsukada, Kenichiro, Ogawa, Kohei, Nakaya, Atsuko, Teramoto, Akira, Nanjo, Sohachi, Mihara, Hiroshi, Fujinami, Haruka, Fujii, Tsutomu, and Yasuda, Ichiro

Subjects
STOMACH tumors, ALBUMINS, CLINICAL trials, CONFIDENCE intervals, PATIENT selection, CANCER chemotherapy, MULTIVARIATE analysis, RETROSPECTIVE studies, METASTASIS, TREATMENT effectiveness, RISK assessment, ELIGIBILITY (Social aspects), DESCRIPTIVE statistics
Abstract

Introduction: Third-line chemotherapy has been suggested to improve survival in patients with gastric cancer. This study aimed to identify factors associated with the induction of third-line chemotherapy for advanced gastric cancer, focusing on patient eligibility for clinical trial. Methods: We retrospectively analyzed 335 patients treated for unresectable or recurrent gastric cancer between April 2009 and May 2020. The patients were grouped into those that met the key eligibility criteria for clinical trial (136 patients, 40.6%) and those that did not (199 patients, 59.4%) before receiving first-line chemotherapy. Results: The overall survival (OS) was 16.8 months (95% CI: 14.0–19.6) and 9.3 months (95% CI: 7.8–11.0) in the eligible and ineligible group, respectively. Multivariate analyses to identify the risk factors associated with the induction of third-line chemotherapy revealed ineligibility of clinical trial (OR 1.95; 95% CI: 1.15–3.31), number of metastatic sites (OR 1.99; 95% CI: 1.23–3.22), low albumin concentration (OR 2.24; 95% CI: 1.14–4.38), and a lack of complete or partial response to first-line treatment (OR 1.85; 95% CI: 1.05–3.26). Indeed, in responders to first-line treatment for ineligible patients, the median OS was 17.7 months (95% CI: 10.6–27.9), respectively. Conclusions: Treatment outcomes were different for those eligible for clinical trials and those who were not. However, this study suggested that patients who responded to first-line treatment have more favorable prognosis when treated with salvage chemotherapy, even if they were deemed ineligible for clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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30. MO5-1 Characteristics of immune-related adverse events in patients with advanced esophageal cancer treated with nivolumab

Author

Nakada, Naokatsu, primary, Ando, Takayuki, additional, Motoo, Iori, additional, Kajiura, Shinya, additional, Fuchino, Mayo, additional, Sakumura, Miho, additional, Nanjo, Sohachi, additional, Mihara, Hiroshi, additional, Fujinami, Haruka, additional, Ogawa, Kohei, additional, Tsukada, Kenichiro, additional, Nakashima, Koji, additional, Hosokawa, Ayumu, additional, and Yasuda, Ichiro, additional

Published
2021
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36. CPC: A Case of Cardiac Arrest in a 94-year-old Woman during Treatments of Heart Failure and Pneumonia after Hematemesis

Author

Fujisaka, Shiho, primary, Tsuji, Hirokazu, additional, Okazawa, Seisuke, additional, Okamoto, Takuya, additional, Otowa, Kanichi, additional, Oikawa, Taku, additional, Kataoka, Naoya, additional, Konoshita, Tadashi, additional, Sato, Yukihiro, additional, Minamizaka, Tadashi, additional, Imura, Johji, additional, Honoki, Hiroyuki, additional, Mihara, Hiroshi, additional, Sakanoue, Yuji, additional, Shikino, Kiyoshi, additional, and Matsumoto, Masataka, additional

Published
2020
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38. Small intestinal mucosal injury and its risk factors in patients with gastrointestinal cancer who developed complicated fluoropyrimidine-induced diarrhea

Author

Sakumura, Miho, primary, Ando, Takayuki, additional, Hosokawa, Ayumu, additional, Nakajima, Takahiko, additional, Motoo, Iori, additional, Mihara, Hiroshi, additional, Ueda, Akira, additional, Kajiura, Shinya, additional, Nanjo, Sohachi, additional, Fujinami, Haruka, additional, Ogawa, Kohei, additional, and Yasuda, Ichiro, additional

Published
2020
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44. Fluoropyrimidine-based chemotherapy for gastrointestinal cancer in patients with direct oral anticoagulants or warfarin

Author

Matsubara, Yuki, primary, Ando, Takayuki, additional, Sakumura, Miho, additional, Yoshita, Hiroki, additional, Nanjo, Sohachi, additional, Mihara, Hiroshi, additional, Fujinami, Haruka, additional, Tsukada, Kenichiro, additional, Shinya, Kajiura, additional, Ogawa, Kohei, additional, Hosokawa, Ayumu, additional, Terada, Mitsuhiro, additional, and Yasuda, Ichiro, additional

Published
2019
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48. Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum

Author

Tokunaga, Mami, primary, Nanjo, Sohachi, additional, Yoshita, Hiroki, additional, Fujinami, Haruka, additional, Watanabe, Tohru, additional, Ishii, Yoko, additional, Kobayashi, Saito, additional, Akashi, Momoko, additional, Takagi, Hiroaki, additional, Mihara, Hiroshi, additional, Kajiura, Shinya, additional, Ando, Takayuki, additional, Hashimoto, Isaya, additional, Hojo, Shozo, additional, Okumura, Tomoyuki, additional, and Sugiyama, Toshiro, additional

Published
2018
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