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1. Human impact on fluvial sediments: how to distinguish regional and local sources of heavy metals contamination

Author

Novakova T., Matys Grygar T., Babek O., Famera M., Mihaljevic M., and Strnad L.

Subjects
Heavy metals, enrichment factors, normalization, fluvial sediments, local sources, regional contamination, Environmental sciences, GE1-350
Abstract

Regional contamination of southern Moravia (SE part of the Czech Republic) by heavy metals and magnetic particles during the 20th century was quantified in fluvial sediments of the Morava River. The influence of local sources to the regional contamination of the river sediments and impact of sampling sites heterogeneity were studied in profiles with different sedimentology (facies) and lithology. For this purpose, hundreds of samples were obtained from regulated channel banks and naturally inundated floodplains and proxy elementary analyses have been carried out by X-ray fluorescence spectroscopy (ED XRF), further calibrated by ICP MS. Magnetic susceptibility as a proxy of industrial contamination was determined and the age model has been obtained by 210Pb dating method. After establishing the lithological background from floodplain profiles, assessment of heavy metal contamination was done by using enrichment factors (EFs) of heavy metals (Pb, Zn, Cu, Cr) and magnetic susceptibility. Floodplain sedimentary profiles were found to be realiable for assessment of contamination and reconstruction of large scale, i.e. a really averaged regional contamination, while regulated channel banks are suitable for obtaining of more or less qualitative information of influence of local point sources in the area because sediments from regulated river banks qualitatively reflect the actual local contamination of the river system. It allowed us to distinguish the influence of local sources of contamination by comparing with more spatially averaged contamination signal from more distal floodplain profiles. The study area is rather weakly contaminated (EF ∼ 1-2), while individual sediment strata from regulated channel banks contains several times larger concentrations of heavy metals.

Published
2013
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10. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Author

Velthorst E., Mollon J., Murray R. M., de Haan L., Germeys I. M., Glahn D. C., Arango C., van der Ven E., Di Forti M., Bernardo M., Guloksuz S., Delespaul P., Mezquida G., Amoretti S., Bobes J., Saiz P. A., Garcia-Portilla M. P., Santos J. L., Jimenez-Lopez E., Sanjuan J., Aguilar E. J., Arrojo M., Carracedo A., Lopez G., Gonzalez-Penas J., Parellada M., Atbasoglu C., Saka M. C., Ucok A., Alptekin K., Akdede B., Binbay T., Altinyazar V., Ulas H., Yalincetin B., Gumus-Akay G., Beyaz B. C., Soygur H., Cankurtaran E. S., Kaymak S. U., Maric N. P., Mihaljevic M. M., Petrovic S. A., Mirjanic T., Del-Ben C. M., Ferraro L., Gayer-Anderson C., Jones P. B., Jongsma H. E., Kirkbride J. B., La Cascia C., Lasalvia A., Tosato S., Llorca P. -M., Menezes P. R., Morgan C., Quattrone D., Menchetti M., Selten J. -P., Szoke A., Tarricone I., Tortelli A., McGuire P., Valmaggia L., Kempton M. J., van der Gaag M., Riecher-Rossler A., Bressan R. A., Barrantes-Vidal N., Nelson B., McGorry P., Pantelis C., Krebs M. -O., Ruhrmann S., Sachs G., Rutten B. P. F., van Os J., Alizadeh B. Z., van Amelsvoort T., Bartels-Velthuis A. A., Bruggeman R., van Beveren N. J., Luykx J. J., Cahn W., Simons C. J. P., Kahn R. S., Schirmbeck F., van Winkel R., Calem M., Tognin S., Modinos G., Pisani S., Kraan T. C., van Dam D. S., Burger N., Amminger G. P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Cristobal-Narvaez P., Racioppi A., Kwapil T. R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Rander L., Krakauer K., Glenthoj L. B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Reichenberg A., Velthorst E., Mollon J., Murray R.M., de Haan L., Germeys I.M., Glahn D.C., Arango C., van der Ven E., Di Forti M., Bernardo M., Guloksuz S., Delespaul P., Mezquida G., Amoretti S., Bobes J., Saiz P.A., Garcia-Portilla M.P., Santos J.L., Jimenez-Lopez E., Sanjuan J., Aguilar E.J., Arrojo M., Carracedo A., Lopez G., Gonzalez-Penas J., Parellada M., Atbasoglu C., Saka M.C., Ucok A., Alptekin K., Akdede B., Binbay T., Altinyazar V., Ulas H., Yalincetin B., Gumus-Akay G., Beyaz B.C., Soygur H., Cankurtaran E.S., Kaymak S.U., Maric N.P., Mihaljevic M.M., Petrovic S.A., Mirjanic T., Del-Ben C.M., Ferraro L., Gayer-Anderson C., Jones P.B., Jongsma H.E., Kirkbride J.B., La Cascia C., Lasalvia A., Tosato S., Llorca P.-M., Menezes P.R., Morgan C., Quattrone D., Menchetti M., Selten J.-P., Szoke A., Tarricone I., Tortelli A., McGuire P., Valmaggia L., Kempton M.J., van der Gaag M., Riecher-Rossler A., Bressan R.A., Barrantes-Vidal N., Nelson B., McGorry P., Pantelis C., Krebs M.-O., Ruhrmann S., Sachs G., Rutten B.P.F., van Os J., Alizadeh B.Z., van Amelsvoort T., Bartels-Velthuis A.A., Bruggeman R., van Beveren N.J., Luykx J.J., Cahn W., Simons C.J.P., Kahn R.S., Schirmbeck F., van Winkel R., Calem M., Tognin S., Modinos G., Pisani S., Kraan T.C., van Dam D.S., Burger N., Amminger G.P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Cristobal-Narvaez P., Racioppi A., Kwapil T.R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Rander L., Krakauer K., Glenthoj L.B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Reichenberg A., RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Neurosciences, Psychiatry, Clinical Developmental Psychology, World Health Organization (WHO) Collaborating Center, Life Course Epidemiology (LCE), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep

Subjects
0301 basic medicine, validity, medicine.medical_treatment, CHILDHOOD, Neuropsychological Tests, FAMÍLIA, episode, Cognition, 0302 clinical medicine, DEFICITS, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, Medicine, Cognitive impairment, Psychiatry, Symptom severity, Cannabis use, IMPAIRMENT, ABILITY, Psychiatry and Mental health, Schizophrenia, RELIABILITY, Neuropsychological Test, Life Sciences & Biomedicine, Human, Clinical psychology, Adult, Biochemistry & Molecular Biology, impairment, schizophrenia-patients, ability, GENETIC RISK, Psychotic Disorder, SCHIZOPHRENIA-PATIENTS, 03 medical and health sciences, Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, Settore M-PSI/08 - Psicologia Clinica, Humans, In patient, Cognitive skill, VALIDITY, Antipsychotic, Molecular Biology, Settore MED/25 - Psichiatria, Aged, Cross-Sectional Studie, DECLINE, Science & Technology, reliability, business.industry, Working memory, Siblings, Neurosciences, Diagnostic markers, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, deficits, Psychotic Disorders, PSYCHOSIS, COGNITION, MULTICENTRIC STUDY, Neurosciences & Neurology, business, EPISODE, 030217 neurology & neurosurgery
Abstract

The European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (EUGEI); The Spanish sample was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024) (...), Velthorst, E., Mollon, J., Murray, R.M., de Haan, L., Germeys, I.M., Glahn, D.C., Arango, C., van der Ven, E., Di Forti, M., Bernardo, M., Guloksuz, S., Delespaul, P., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., García-Portilla, M.P., Santos, J.L., Jiménez-López, E., Sanjuan, J., Aguilar, E.J., Arrojo, M., Carracedo, A., López, G., González-Peñas, J., Parellada, M., Atbaşoğlu, C., Saka, M.C., Üçok, A., Alptekin, K., Akdede, B., Binbay, T., Altınyazar, V., Ulaş, H., Yalınçetin, B., Gümüş-Akay, G., Beyaz, B.C., Soygür, H., Cankurtaran, E.Ş., Kaymak, S.U., Maric, N.P., Mihaljevic, M.M., Petrovic, S.A., Mirjanic, T., Del-Ben, C.M., Ferraro, L., Gayer-Anderson, C., Jones, P.B., Jongsma, H.E., Kirkbride, J.B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P.-M., Menezes, P.R., Morgan, C., Quattrone, D., Menchetti, M., Selten, J.-P., Szöke, A., Tarricone, I., Tortelli, A., McGuire, P., Valmaggia, L., Kempton, M.J., van der Gaag, M., Riecher-Rössler, A., Bressan, R.A., Barrantes-Vidal, N., Nelson, B., McGorry, P., Pantelis, C., Krebs, M.-O., Ruhrmann, S., Sachs, G., Rutten, B.P.F., van Os, J., Alizadeh, B.Z., van Amelsvoort, T., Bartels-Velthuis, A.A., Bruggeman, R., van Beveren, N.J., Luykx, J.J., Cahn, W., Simons, C.J.P., Kahn, R.S., Schirmbeck, F., van Winkel, R., Calem, M., Tognin, S., Modinos, G., Pisani, S., Kraan, T.C., van Dam, D.S., Burger, N., Amminger, G.P., Politis, A., Goodall, J., Borgwardt, S., Studerus, E., Gadelha, A., Brietzke, E., Asevedo, G., Asevedo, E., Zugman, A., Domínguez-Martínez, T., Monsonet, M., Cristóbal-Narváez, P., Racioppi, A., Kwapil, T.R., Kazes, M., Daban, C., Bourgin, J., Gay, O., Mam-Lam-Fook, C., Nordholm, D., Rander, L., Krakauer, K., Glenthøj, L.B., Glenthøj, B., Gebhard, D., Arnhold, J., Klosterkötter, J., Lasser, I., Winklbaur, B., Reichenberg, A., EU-GEI High Risk Study

Published
2021
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15. Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: results from the EUGEI study

Author

Erzin G, Pries L, van Os J, Fusar-Poli L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S, and Genetic Risk and Outcome of Psychosis (GROUP) investigators

Published
2021

16. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study

Author

van Os J, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S, and Genetic Risk Outcome Investigators

Subjects
schizophrenia, Cognition, schizotypy, genetics
Abstract

Background First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. Methods We conducted, using two different samples for discovery (n= 336 controls and 649 siblings of patients with psychotic disorder) and replication (n= 1208 controls and 1106 siblings), an analysis of association between PRS on the one hand and psychopathological and cognitive intermediate phenotypes of schizophrenia on the other in a sample at average genetic risk (healthy controls) and a sample at higher than average risk (healthy siblings of patients). Two subthreshold psychosis phenotypes, as well as a standardised measure of cognitive ability, based on a short version of the WAIS-III short form, were used. In addition, a measure of jumping to conclusion bias (replication sample only) was tested for association with PRS. Results In both discovery and replication sample, evidence for an association between PRS and subthreshold psychosis phenotypes was observed in the relatives of patients, whereas in the controls no association was observed. Jumping to conclusion bias was similarly only associated with PRS in the sibling group. Cognitive ability was weakly negatively and non-significantly associated with PRS in both the sibling and the control group. Conclusions The degree of endophenotypic expression of schizophrenia polygenic risk depends on having a sibling with psychotic disorder, suggestive of underlying gene-environment interaction. Cognitive biases may better index genetic risk of disorder than traditional measures of neurocognition, which instead may reflect the population distribution of cognitive ability impacting the prognosis of psychotic disorder.

Published
2020

17. Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum

Author

Pries L, Dal Ferro G, van Os J, Delespaul P, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Tosato S, Rutten B, Guloksuz S, and Genetic Risk Outcome Psychosis GRP

Subjects
schizotypy, genetics, psychosis, Environment
Abstract

Aims Psychosis spectrum disorder has a complex pathoetiology characterised by interacting environmental and genetic vulnerabilities. The present study aims to investigate the role of gene-environment interaction using aggregate scores of genetic (polygenic risk score for schizophrenia (PRS-SCZ)) and environment liability for schizophrenia (exposome score for schizophrenia (ES-SCZ)) across the psychosis continuum. Methods The sample consisted of 1699 patients, 1753 unaffected siblings, and 1542 healthy comparison participants. The Structured Interview for Schizotypy-Revised (SIS-R) was administered to analyse scores of total, positive, and negative schizotypy in siblings and healthy comparison participants. The PRS-SCZ was trained using the Psychiatric Genomics Consortiums results and the ES-SCZ was calculated guided by the approach validated in a previous report in the current data set. Regression models were applied to test the independent and joint effects of PRS-SCZ and ES-SCZ (adjusted for age, sex, and ancestry using 10 principal components). Results Both genetic and environmental vulnerability were associated with case-control status. Furthermore, there was evidence for additive interaction between binary modes of PRS-SCZ and ES-SCZ (above 75% of the control distribution) increasing the odds for schizophrenia spectrum diagnosis (relative excess risk due to interaction = 6.79, [95% confidential interval (CI) 3.32, 10.26], p < 0.001). Sensitivity analyses using continuous PRS-SCZ and ES-SCZ confirmed gene-environment interaction (relative excess risk due to interaction = 1.80 [95% CI 1.01, 3.32], p = 0.004). In siblings and healthy comparison participants, PRS-SCZ and ES-SCZ were associated with all SIS-R dimensions and evidence was found for an interaction between PRS-SCZ and ES-SCZ on the total (B = 0.006 [95% CI 0.003, 0.009], p < 0.001), positive (B = 0.006 [95% CI, 0.002, 0.009], p = 0.002), and negative (B = 0.006, [95% CI 0.004, 0.009], p < 0.001) schizotypy dimensions. Conclusions The interplay between exposome load and schizophrenia genetic liability contributing to psychosis across the spectrum of expression provide further empirical support to the notion of aetiological continuity underlying an extended psychosis phenotype.

Published
2020

20. Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study

Author

Pries L, Lage-Castellanos A, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, van Os J, Guloksuz S, Alizadeh B, van Amelsvoort T, Bruggeman R, Cahnm W, de Haan L, van Winkel R, and Genetic Risk Outcome Psychosis Grp

Subjects
schizophrenia, cannabis, machine learning, childhood trauma, psychosis, hearing impairment, risk score, predictive modeling, environment, winter birth
Abstract

Exposures constitute a dense network of the environment: exposome. Here, we argue for embracing the exposome paradigm to investigate the sum of nongenetic "risk" and show how predictive modeling approaches can be used to construct an exposome score (ES; an aggregated score of exposures) for schizophrenia. The training dataset consisted of patients with schizophrenia and controls, whereas the independent validation dataset consisted of patients, their unaffected siblings, and controls. Binary exposures were cannabis use, hearing impairment, winter birth, bullying, and emotional, physical, and sexual abuse along with physical and emotional neglect. We applied logistic regression (LR), Gaussian Naive Bayes (GNB), the least absolute shrinkage and selection operator (LASSO), and Ridge penalized classification models to the training dataset. ESs, the sum of weighted exposures based on coefficients from each model, were calculated in the validation dataset. In addition, we estimated ES based on meta-analyses and a simple sum score of exposures. Accuracy, sensitivity, specificity, area under the receiver operating characteristic, and Nagelkerke's R-2 were compared. The ESMeta-analyses performed the worst, whereas the sum score and the ESGNB were worse than the ESLR that performed similar to the ESLASSO and ESRIDGE. The ESLR distinguished patients from controls (odds ratio [OR] = 1.94, P < .001), patients from siblings (OR = 1.58, P < .001), and siblings from controls (OR = 1.21, P= .001). An increase in ESLR was associated with a gradient increase of schizophrenia risk. In reference to the remaining fractions, the ESLR at top 30%, 20%, and 10% of the control distribution yielded ORs of 3.72, 3.74, and 4.77, respectively. Our findings demonstrate that predictive modeling approaches can be harnessed to evaluate the exposome.

Published
2019

21. Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study

Author

Guloksuz S, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalincetin B, Gumus-Akay G, Cihan B, Soygur H, Ulas H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, Garcia-Portilla M, Sanjuan J, Aguilar E, Santos J, Jimenez-Lopez E, Arrojo M, Carracedo A, Lopez G, Gonzalez-Penas J, Parellada M, Maric N, Atbasoglu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, van Os J, Alizadeh B, van Amelsvoort T, van Beveren N, Bruggeman R, Cahn W, de Haan L, Myin-Germeys I, van Winkel R, and Genetic Risk Outcome Psychosis

Published
2019

26. Unravelling the depositional origins and diagenetic alteration of carbonate breccias

Author

Madden, Robert, Wilson, M., Mihaljevic, M., Pandolfi, J., Welsh, K., Madden, Robert, Wilson, M., Mihaljevic, M., Pandolfi, J., and Welsh, K.

Abstract

Carbonate breccias dissociated from their platform top counterparts are little studied despite their potential to reveal the nature of past shallow-water carbonate systems and the sequential alteration of such systems. A petrographic and stable isotopic study allowed evaluation of the sedimentological and diagenetic variability of the Cenozoic Batu Gading Limestone breccia of Borneo. Sixteen lithofacies representing six facies groups have been identified mainly from the breccia clasts on the basis of shared textural and compositional features. Clasts of the breccia are representative of shallow carbonate platform top and associated flank to basinal deposits. Dominant inputs are from rocky (karstic) shorelines or localised seagrass environments, coral patch reef and larger foraminiferal-rich deposits. Early, pre-brecciation alteration (including micritisation, rare dissolution of bioclasts, minor syntaxial overgrowth cementation, pervasive neomorphism and calcitisation of bioclasts and matrix) was mainly associated with marine fluids in a near surface to shallow burial environment. The final stages of pre-brecciation diagenesis include mechanical compaction and cementation of open porosity in a shallow to moderate depth burial environment. Post-brecciation diagenesis took place at increasingly moderate to deep burial depths under the influence of dominantly marine burial fluids. Extensive compaction, circum-clast dissolution seams and stylolites have resulted in a tightly fitted breccia fabric, with some development of fractures and calcite cements. A degree of facies-specific controls are evident for the pre-brecciation diagenesis. Pervasive mineralogical stabilisation and cementation have, however, led to a broad similarity of diagenetic features in the breccia clasts thereby effectively preserving depositional features of near-original platform top and margin environments. There is little intra-clast alteration overprint associated with subsequent clast r

Published
2017

31. Identification and characterization of grapevine genetic resources maintained in Eastern European Collections

Author

Maul, E., Toepfer, R., Carka, F., Cornea, V., Crespan, M., Dallakyan, M., Andres Dominguez, T., Lorenzis, G., Dejeu, L., Goryslavets, S., Maria Stella Grando, Hovannisyan, N., Hudcovicova, M., Hvarleva, T., Ibanez, J., Kiss, E., Kocsis, L., Lacombe, T., Laucou, V., Maghradze, D., Maletic, E., Melyan, G., Mihaljevic, M. Z., Munoz-Organero, G., Musayev, M., Nebish, A., Popescu, C. F., Regner, F., Risovanna, V., Ruisa, S., Salimov, V., Savin, G., Schneider, A., Stajner, N., Ujmajuridze, L., Failla, O., Institut für Rebenzüchtung Geilweilerhof, Julius Kühn-Institut (JKI), Agricultural University of Tirana, Research and Practical Institute for Horticulture and Food Technologies, Centro di ricerca per la Viticoltura (CRAVIT), Department of Ecology and Nature Protection, University of Podlasie, Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario (IMIDRA), Università degli Studi di Milano [Milano] (UNIMI), Faculty of Horticulture, University of Agronomical Sciences and Veterinary Medicine, National Institute for Vine and Wine ‘Magarach’, Istituto Agrario di San Michele all'Adige (IASMA), Plant Production Research, AgroBioInstitute, Instituto de Ciencias de la Vid y el Vino - Institute of Grapevine and Wine Sciences, Partenaires INRAE, Institute of Genetics and Biotechnology, Szent István University, University of Pannonia, Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institute of Horticulture, Viticulture and Oenology, Agricultural University of Georgia, Department of Viticulture and Enology [Zagreb], Faculty of Agriculture [Zagreb] (UNIZG), University of Zagreb-University of Zagreb, Academy of Viticulture and Wine-making, Azerbaijan National Academy of Sciences (ANAS), HBLAuBA Klosterneuburg, State Institute of Fruit-Growing, Azerbaijani Scientific Research Institute of Viticulture and Winemaking, Istituto di Virologia Vegetale, Università degli studi di Torino (UNITO), University of Ljubljana, and National Center for Grapevine and Fruit Tree Planting Material Propagation (AGRO)

Subjects
0106 biological sciences, Identification, biodiversity, grapevine, microsatellites, identification, documentation, germplasm preservation, Characterization, Documentation, 01 natural sciences, Germplasm preservation, 03 medical and health sciences, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Microsatellites, Genetic resources, 030304 developmental biology, 0303 health sciences, Biodiversity, Settore AGR/07 - GENETICA AGRARIA, Eastern Europe collection, Grapevine, 010606 plant biology & botany
Abstract

The Near East and the Caucasus regions are considered as gene and domestication centre for grapevine. In an earlier project “Conservation and Sustainable Use of Grapevine Genetic Resources in the Caucasus and Northern Black Sea Region” (2003-2007) it turned out that 2,654 accessions from autochthonous cultivars maintained by Armenia, Azerbaijan, Georgia, Moldova, Russian Federation and Ukraine in ten grapevine collections may belong to 1,283 cultivars. But trueness to type assessment by morphology and genetic fingerprinting still needed to be done. In COST Action FA1003 a first step in that direction was initiated. The following countries participated: Albania, Armenia, Austria, Azerbaijan, Bulgaria, Croatia, Georgia, Hungary, Latvia, Moldova, Romania, Slovakia, Slovenia and Ukraine. Mainly Vitis vinifera accessions (1098 samples) and 76 Vitis sylvestris individuals were analyzed by nine SSR-markers (VVS2, VVMD5, VVMD7, VVMD25, VVMD27, VVMD28, VVMD32, VrZag62, VrZag79). Cultivar identity confirmation/rejection was attempted for 306 genotypes/cultivars by comparison of the generated genetic profiles with international SSR-marker databases and ampelographic studies. The outcome proved unambiguously the necessity of morphologic description and photos (a) for comparison with bibliography, (b) for a clear and explicit definition of the cultivar and (c) the detection of sampling errors and misnomers. From the 1,098 analyzed accessions, 997 turned out to be indigenous to the participating countries. The remaining 101 accessions were Western European cultivars. The 997 fingerprints of indigenous accessions resulted in 658 unique profiles/cultivars. From these 353 (54 %) are only maintained in the countries of origin and 300 (46 %) unique genotypes exist only once in the Eastern European collections. For these 300 genotypes duplicate preservation needs to be initiated. In addition, the high ratio of non redundant genetic material of Eastern European origin suggests an immense unexplored diversity. Documentation of the entire information in the European Vitis Database will assist both germplasm maintenance and documentation of cultivar specific data., VITIS - Journal of Grapevine Research, Vol. 54 (2015): Vitis (Special Issue)

Published
2015

32. Identifying gene-environment interactions in schizophrenia: Contemporary challenges for integrated, large-scale investigations

Author

Van Os, J. Rutten, B.P. Myin-Germeys, I. Delespaul, P. Viechtbauer, W. Van Zelst, C. Bruggeman, R. Reininghaus, U. Morgan, C. Murray, R.M. Di Forti, M. McGuire, P. Valmaggia, L.R. Kempton, M.J. Gayer-Anderson, C. Hubbard, K. Beards, S. Stilo, S.A. Onyejiaka, A. Bourque, F. Modinos, G. Tognin, S. Calem, M. O'Donovan, M.C. Owen, M.J. Holmans, P. Williams, N. Craddock, N. Richards, A. Humphreys, I. Meyer-Lindenberg, A. Leweke, F.M. Tost, H. Akdeniz, C. Rohleder, C. Bumb, J.M. Schwarz, E. Alptekin, K. Üçok, A. Saka, M.C. Atbagoǧlu, E.C. Gülöksüz, S. Gumus-Akay, G. Cihan, B. Karadaǧ, H. Soygür, H. Cankurtaran, E.S. Ulusoy, S. Akdede, B. Binbay, T. Ayer, A. Noyan, H. Karadayi, G. Akturan, E. Ulaş, H. Arango, C. Parellada, M. Bernardo, M. Sanjuán, J. Bobes, J. Arrojo, M. Santos, J.L. Cuadrado, P. Solano, J.J.R. Carracedo, A. Bernardo, E.G. Roldán, L. López, G. Cabrera, B. Cruz, S. Mesa, E.M.D. Pouso, M. Jiménez, E. Sánchez, T. Rapado, M. González, E. Martínez, C. Sánchez, E. Olmeda, M.S. De Haan, L. Velthorst, E. Van Der Gaag, M. Selten, J.-P. Van Dam, D. Van Der Ven, E. Van Der Meer, F. Messchaert, E. Kraan, T. Burger, N. Leboyer, M. Szoke, A. Schürhoff, F. Llorca, P.-M. Jamain, S. Tortelli, A. Frijda, F. Vilain, J. Galliot, A.-M. Baudin, G. Ferchiou, A. Richard, J.-R. Bulzacka, E. Charpeaud, T. Tronche, A.-M. De Hert, M. Van Winkel, R. Decoster, J. Derom, C. Thiery, E. Stefanis, N.C. Sachs, G. Aschauer, H. Lasser, I. Winklbaur, B. Schlögelhofer, M. Riecher-Rössler, A. Borgwardt, S. Walter, A. Harrisberger, F. Smieskova, R. Rapp, C. Ittig, S. Soguel-Dit-Piquard, F. Studerus, E. Klosterkötter, J. Ruhrmann, S. Paruch, J. Julkowski, D. Hilboll, D. Sham, P.C. Cherny, S.S. Chen, E.Y.H. Campbell, D.D. Li, M. Romeo-Casabona, C.M. Cirión, A.E. Mora, A.U. Jones, P. Kirkbride, J. Cannon, M. Rujescu, D. Tarricone, I. Berardi, D. Bonora, E. Seri, M. Marcacci, T. Chiri, L. Chierzi, F. Storbini, V. Braca, M. Minenna, M.G. Donegani, I. Fioritti, A. La Barbera, D. La Cascia, C.E. Mulè, A. Sideli, L. Sartorio, R. Ferraro, L. Tripoli, G. Seminerio, F. Marinaro, A.M. McGorry, P. Nelson, B. Amminger, G.P. Pantelis, C. Menezes, P.R. Del-Ben, C.M. Tenan, S.H.G. Shuhama, R. Ruggeri, M. Tosato, S. Lasalvia, A. Bonetto, C. Ira, E. Nordentoft, M. Krebs, M.-O. Barrantes-Vidal, N. Cristóbal, P. Kwapil, T.R. Brietzke, E. Bressan, R.A. Gadelha, A. Maric, N.P. Andric, S. Mihaljevic, M. Mirjanic, T.

Abstract

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. © 2014 The Author.

Published
2014

39. Istrazivanje domacina B-virusa vinove loze medu zeljastim biljnim vrstama -(Survey of Grapevine virus B hosts among herbaceous plants))

Author

Voncina D., Mihaljevic M., and De Stradis A

Subjects
herbaceous hosts, ELECTRON MICROSCOPY, GVB
Abstract

Istra?ivanje doma?ina B-virusa vinove loze (GVB) provedeno je na 24 zeljaste biljne vrste. U fazi pogodnoj za mehani?ku inokulaciju po 4 biljke svake vrste inokulirane su sa dva razli?ita GVB izolata: PM i MA. Mjesec dana nakon inokulacije uspje?nost prijenosa provjerena je metodom ELISA. Uspje?an prijenos ostvaren je kod vrsta Nicotiana cavicola N. T. Burb. i N. occidentalis H.- M.Wheeler. Dvije biljke (N. glutinosa L. inokulirana izolatom MR i Impatiens walleriana cv. Jambalaya(TM) inokulirana izolatom PM) s upitnim ELISA-rezultatima provjerene su metodom RT-PCR i elektronskom mikroskopijom uz dobivene negativne rezultate. Provedenim istra?ivanjem nisu utvr?eni novi zeljasti doma?ini osim onih ve? ranije poznatih.

Published
2013

40. Multielemental Chemical Analysis of Elements in Mandibular Bone and Teeth in the Rat.

Author

NĚMEC, I., SMRČKA, V., MIHALJEVIC, M., MAZÁNEK, J., and POKORNÝ, J.

Subjects
MANDIBULAR joint, ANALYTICAL chemistry, INCISORS, LABORATORY rats, BONE density
Abstract

The purpose of the study was to test the hypothesis of different distribution spaces of elements in the rat mandibular bone and teeth. We used six adult males of Wistar laboratory rats for the study. After killing the animals, we extracted the molars and removed incisor crowns. The mandibular bone was divided into four parts (mesial-central-distal- ridge). Inductively coupled plasma mass spectrometry was used to determine the presence of 41 elements in the bone and tooth. Evidence of 14 elements was found in all samples (incisors-molarsbone). Generally, significant differences between the left and right side were found for K and Rb in the bone locations. As regards statistically significant differences in incisors-molars-bone locations, the elements for which these differences were found for all comparisons are listed as incisors versus individual molars, incisors versus bone locations, and individual molars versus bone locations: a) incisors-molars: Ba, Mn, Mo, Sr, Zn, K, Mg and Rb; b) incisors-bone: Fe, K, Mg, Mn, Na, Zn and Ba; c) molars-bone: Mn, Mo, Na and Mg. Statistically significant differences were also found between molars for Fe, Mg, Mn, and Sr and between bone locations for Ba, Ca, Mn, Sr, K, Rb, Zn, Mo, Mg, and Na. The elements Cu, Ni and Co were without pronounced differences. Twenty-seven elements were below the detection limit. Our results indicate different distributions of some elements in the rat mandibular incisors-molars-bone. We assume that the knowledge of chemical element contents in the laboratory rat bone and teeth will prove useful in experimental research of both these hard tissues. [ABSTRACT FROM AUTHOR]

Published
2018
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44. The pH-static leaching behaviour of metallurgical wastes from the Tsumeb Copper Smelter (Namibia).

Author

Jarosikova A., Addressing environmental and health impacts of active and abandoned mines in Sub-Saharan Africa. Closing Workshop of the IGCP/SIDA Projects 594 & 606 Prague, Czech Republic 26-May-1428-May-14, Ettler V., Kribek B., Mihaljevic M., Sebek O., Jarosikova A., Addressing environmental and health impacts of active and abandoned mines in Sub-Saharan Africa. Closing Workshop of the IGCP/SIDA Projects 594 & 606 Prague, Czech Republic 26-May-1428-May-14, Ettler V., Kribek B., Mihaljevic M., and Sebek O.

Abstract

Bag house dust and four different slags (converter, reverb, ausmelt slags and slag dust) from the Tsumeb Copper Smelter (Namibia) were studied. The pH-static leaching tests (pH range 3-12) were used and contaminant leachabilities at natural pH were compared with EU criteria for non-hazardous and hazardous wastes. Bag house dust exhibited high leaching of As (up to 314 g/kg) and exceeded the limit value for hazardous waste by more than 2 000 times. The leaching of contaminants from slags was more pH-dependent, with highest Cu and Pb release under acidic conditions (up to 1 780 and 752 mg/kg, respectively). Metal leaching at natural pH was very low, far below the limits for non-hazardous wastes. Arsenic exhibited V-shaped leaching patterns with minimum at pH 6 for all the slag samples. Extremely high levels of As were found to be leaching from the bag house dust whereas they only exceeded the limit for hazardous waste from ausmelt slags. Safety measures are currently adopted in the smelter to protect the workers from bag house dusts. The risk of contaminant leaching from slag particles wind-deposited in soils seems to be limited., Bag house dust and four different slags (converter, reverb, ausmelt slags and slag dust) from the Tsumeb Copper Smelter (Namibia) were studied. The pH-static leaching tests (pH range 3-12) were used and contaminant leachabilities at natural pH were compared with EU criteria for non-hazardous and hazardous wastes. Bag house dust exhibited high leaching of As (up to 314 g/kg) and exceeded the limit value for hazardous waste by more than 2 000 times. The leaching of contaminants from slags was more pH-dependent, with highest Cu and Pb release under acidic conditions (up to 1 780 and 752 mg/kg, respectively). Metal leaching at natural pH was very low, far below the limits for non-hazardous wastes. Arsenic exhibited V-shaped leaching patterns with minimum at pH 6 for all the slag samples. Extremely high levels of As were found to be leaching from the bag house dust whereas they only exceeded the limit for hazardous waste from ausmelt slags. Safety measures are currently adopted in the smelter to protect the workers from bag house dusts. The risk of contaminant leaching from slag particles wind-deposited in soils seems to be limited.

Published
2014

45. Mobility of vanadium and arsenic in mine tailings in semiarid northeastern Namibia.

Author

Sracek O., Addressing environmental and health impacts of active and abandoned mines in Sub-Saharan Africa. Closing Workshop of the IGCP/SIDA Projects 594 & 606 Prague, Czech Republic 26-May-1428-May-14, Ettler V., Knesl I., Kribek B., Majer V., Mapani B., Mihaljevic M., Penizek V., Vanek A., Sracek O., Addressing environmental and health impacts of active and abandoned mines in Sub-Saharan Africa. Closing Workshop of the IGCP/SIDA Projects 594 & 606 Prague, Czech Republic 26-May-1428-May-14, Ettler V., Knesl I., Kribek B., Majer V., Mapani B., Mihaljevic M., Penizek V., and Vanek A.

Abstract

Two sites in the semi-arid Otavi Mountain Land in NE Namibia have been investigated. At Berg Aukas, V rich mine tailings are over 30 years old, but most V remains in primary descloizite embedded in carbonate matrix. Released V was incorporated into ferric hydroxides later transformed to haematite. In contrast, released Zn and Pb were incorporated into smithsonite and cerussite, which are less stable from environmental viewpoint. At Kombat mine tailings, As released from pyrite was also incorporated into haematite, but Cu from dissolution of chalcopyrite and bornite precipitated as malachite and cerussite, which are also much less stable than haematite. It seems that formation of haematite, which is relatively fast in tropical climate conditions, is favourable for attenuation of contaminants released into pore water. (Authors.), Two sites in the semi-arid Otavi Mountain Land in NE Namibia have been investigated. At Berg Aukas, V rich mine tailings are over 30 years old, but most V remains in primary descloizite embedded in carbonate matrix. Released V was incorporated into ferric hydroxides later transformed to haematite. In contrast, released Zn and Pb were incorporated into smithsonite and cerussite, which are less stable from environmental viewpoint. At Kombat mine tailings, As released from pyrite was also incorporated into haematite, but Cu from dissolution of chalcopyrite and bornite precipitated as malachite and cerussite, which are also much less stable than haematite. It seems that formation of haematite, which is relatively fast in tropical climate conditions, is favourable for attenuation of contaminants released into pore water. (Authors.)

Published
2014

46. Dust from selected African metal smelters: mineralogy, contaminant bioaccessibility and exposure estimations.

Author

Ettler V., Addressing environmental and health impacts of active and abandoned mines in Sub-Saharan Africa. Closing Workshop of the IGCP/SIDA Projects 594 & 606 Prague, Czech Republic 26-May-1428-May-14, Kamona F., Kribek B., Majer V., Mapani B., Mihaljevic M., Nyambe I., Penizek V., Sebek O., Sracek O., Vanek A., Veselovsky F., Vitkova M., Ettler V., Addressing environmental and health impacts of active and abandoned mines in Sub-Saharan Africa. Closing Workshop of the IGCP/SIDA Projects 594 & 606 Prague, Czech Republic 26-May-1428-May-14, Kamona F., Kribek B., Majer V., Mapani B., Mihaljevic M., Nyambe I., Penizek V., Sebek O., Sracek O., Vanek A., Veselovsky F., and Vitkova M.

Abstract

Dusts from metal smelters in the Zambian Copperbelt and northern Namibia were investigated using a combination of mineralogical techniques (XRD, SEM/EDS, TEM/EDS) in order to understand the solid speciation of the contaminants, as well as their bioaccessibility using in vitro tests in simulated gastric and lung fluids to assess the exposure risk for humans. The leaching of metals was mainly dependent on the contaminant mineralogy. A potential risk can be recognised, particularly from ingestion of the dust, with bioaccessible fractions ranging from 5 to 89% of the total contaminant concentrations. Relatively low bioaccessible fractions were observed for simulated lung fluid extracts (carried out only on Zambian dusts), with values ranging from 0.01% (Pb) up to 16.5% (Co) of total contaminant concentrations. Daily intakes calculated for adult oral exposure slightly exceeded the tolerable daily intake limits for Co, Pb, and As., Dusts from metal smelters in the Zambian Copperbelt and northern Namibia were investigated using a combination of mineralogical techniques (XRD, SEM/EDS, TEM/EDS) in order to understand the solid speciation of the contaminants, as well as their bioaccessibility using in vitro tests in simulated gastric and lung fluids to assess the exposure risk for humans. The leaching of metals was mainly dependent on the contaminant mineralogy. A potential risk can be recognised, particularly from ingestion of the dust, with bioaccessible fractions ranging from 5 to 89% of the total contaminant concentrations. Relatively low bioaccessible fractions were observed for simulated lung fluid extracts (carried out only on Zambian dusts), with values ranging from 0.01% (Pb) up to 16.5% (Co) of total contaminant concentrations. Daily intakes calculated for adult oral exposure slightly exceeded the tolerable daily intake limits for Co, Pb, and As.

Published
2014

47. Fate of smelter particulates in tropical soils.

Author

Ettler V., Addressing environmental and health impacts of active and abandoned mines in Sub-Saharan Africa. Closing Workshop of the IGCP/SIDA Projects 594 & 606 Prague, Czech Republic 26-May-1428-May-14, Kamona F., Kribek B., Majer V., Mapani B., Mihaljevic M., Nyambe I., Penizek V., Sebek O., Sracek O., Vanek A., Veselovsky F., Ettler V., Addressing environmental and health impacts of active and abandoned mines in Sub-Saharan Africa. Closing Workshop of the IGCP/SIDA Projects 594 & 606 Prague, Czech Republic 26-May-1428-May-14, Kamona F., Kribek B., Majer V., Mapani B., Mihaljevic M., Nyambe I., Penizek V., Sebek O., Sracek O., Vanek A., and Veselovsky F.

Abstract

Highly polluted topsoil from the vicinity of the Mufulira Cu Smelter (Zambia) and Tsumeb Cu-Pb Smelter (Namibia) were studied to determine the distribution and weathering features of smelter-derived particulates. X-ray diffraction analysis of heavy mineral soil fraction generally detected rock-derived phases (zircons, tourmaline, rutile, residual carbonates) and only rarely metal-bearing phases. However, SEM/EDS identified numerous anthropogenic metal-bearing particles in the most polluted soil layers at both sites. In the Cu-smelting areas, spherical particles mainly composed of covellite (CuS) and chalcocite (Cu2S) were detected, while angular grains of chalcopyrite (CuFeS2) were attributed to mining-derived tailings. Fe-Cu oxide particles were detected along with hydrated Fe-oxides corresponding to secondary weathering products. Laboratory pot experiments were conducted to understand the weathering of smelter dusts in a typical red tropical soil (Oxisol). Dust from the Mufulira Smelter (soluble sulphates) was highly reactive when incubated in soil. The released Cu became bound in the labile soil fraction and was susceptible to vertical migration in the soil profiles, whereas other metal-bearing phases were more resistant to weathering and subsequent release of contaminants., Highly polluted topsoil from the vicinity of the Mufulira Cu Smelter (Zambia) and Tsumeb Cu-Pb Smelter (Namibia) were studied to determine the distribution and weathering features of smelter-derived particulates. X-ray diffraction analysis of heavy mineral soil fraction generally detected rock-derived phases (zircons, tourmaline, rutile, residual carbonates) and only rarely metal-bearing phases. However, SEM/EDS identified numerous anthropogenic metal-bearing particles in the most polluted soil layers at both sites. In the Cu-smelting areas, spherical particles mainly composed of covellite (CuS) and chalcocite (Cu2S) were detected, while angular grains of chalcopyrite (CuFeS2) were attributed to mining-derived tailings. Fe-Cu oxide particles were detected along with hydrated Fe-oxides corresponding to secondary weathering products. Laboratory pot experiments were conducted to understand the weathering of smelter dusts in a typical red tropical soil (Oxisol). Dust from the Mufulira Smelter (soluble sulphates) was highly reactive when incubated in soil. The released Cu became bound in the labile soil fraction and was susceptible to vertical migration in the soil profiles, whereas other metal-bearing phases were more resistant to weathering and subsequent release of contaminants.

Published
2014

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