Search

Author Contributions A.M.-B. wrote the manuscript, contributed to the design of the survey, data analysis and she also contributed to preparing the tables. M.F.-R. contributed to the conception and design of the manuscript, data analysis, preparing the tables, drafting the manuscript, and reviewed successive drafts of the paper. D.D.-R. contributed to the design of the survey, drafting the manuscript, and reviewed successive drafts of the paper. G.O.-D. contributed to the design of the statistical analysis, data analysis, preparing the tables and reviewed the manuscript. L.R. contributed to the conception and design of the manuscript and funding acquisition. J.A.D.P.-M. contributed to the conception and design of the survey and the manuscript, data analysis, drafting the manuscript, preparing the tables, and reviewed successive drafts of the paper. J.A.D.P.-M. is the principal investigator. All authors have read and agreed to the published version of the manuscript., Since the time of Hippocrates in the 4th century BC, animal research has been extensively used for various purposes up to the present day. However, the use of animals for research has also been controversial for a long time. We report the findings of a public, online questionnaire-based survey designed to assess the opinions of a sample of Spanish society regarding animal research. Demographic data and opinions were obtained from 806 respondents. The results indicated a high level of acceptance of animal research (73.1%). However, certain factors, such as completing the questionnaire immediately after a reading negative media report (OR = 2.41; 95%CI: 1.64–3.54; p < 0.001), being a woman (OR = 1.77; 95%CI: 1.24–2.53; p = 0.002) or having a non-scientific background (OR = 2.47; 95%CI: 1.76–3.47; p < 0.001), were associated with a tendency towards a more negative opinion. The opinions seemed to be influenced by gender, education level and by protest incidents reported in the media. Our results also indicate that a lot of information regarding animal welfare, such as care and handling protocols, along with legislation was unknown to individuals. Further, a growing popularity of companion species and opposition to animal experimentation for non-biomedical purposes were reflected in the responses obtained. The use of animals for research purposes emerged as a sensitive social issue in terms of concerns about animal ethics and welfare., Depto. de Fisiología, Fac. de Veterinaria, TRUE, pub

The use of 3D models in teaching and veterinary medicine has increased during the last years, proving to be very useful in the understanding of anatomy. In the fields of protection and conservation of birds of prey, knowing the specific osteology of each species is vital for the identification of skeletal remains and population control, being 3D modeling a useful tool to carry out this purpose. The aim of this study was to obtain a series of virtual and physical 3D models to characterize the skeleton of the White-Tailed eagle (Haliaeetus albicilla), an endangered bird of prey species recently reintroduced in Spain, as a way of exploring new ways of improving and innovating education and wildlife conservation. Indeed, virtual and physical 3D models can be used for teaching and learning anatomy both in person and remotely. On the other hand, the characterization of each bone allows a better understanding of this species and can also be used as a tool for the identification of skeletal remains. To obtain virtual anatomical models, two specimens of White-Tailed eagle were studied and two 3D modeling techniques were employed: on the one hand, a structured light scanner and on the other, the 3D Slicer Software to segment DICOM (Digital Imaging and Communications in Medicine) images obtained by CT (Computed Axial Tomography). Both techniques resulted in virtual 3D models of each bone of interest in .STL format that were uploaded to the Sketchfab platform (https://sketchfab.com/) for visualization, including landmarks and measurements of each bone. Those same measurements were taken again on one of the specimens by hand, with a digital caliper, to compare the measurement tools as well as the accuracy of the 3D model. In addition to the virtual models, physical 3D printed models of the bones of one of the specimens were obtained. This work helped understanding the usefulness of 3D virtual and printed models in teaching and learning anatomy, their possible use in conservation

2023 Acuerdos Transformativos CRUE, Congenital coagulopathies have, throughout the history of medicine, been a focus of scientific study and of great interest as they constitute an alteration of one of the most important and conserved pathways of evolution. The first therapeutic strategies developed to address them were aimed at restoring the blood components lost during hemorrhage by administering whole blood or plasma. Later on, the use of cryoprecipitates was a significant breakthrough as it made it possible to decrease the volumes of blood infused. In the 1970′ and 80′, clotting factor concentrates became the treatment and, from the 1990's to the present day, recombinant factors –with increasingly longer half-lives– have taken over as the treatment of choice for certain coagulopathies in a seamless yet momentous transition from biological to biotechnological drugs. The beginning of this century, however, saw the emergence of new advanced (gene and cell) treatments, which are currently transforming the therapeutic landscape. The possibility to use cells and viruses as well as specific or bispecific antibodies as medicines is likely to spark a revolution in the world of pharmacology where therapies will be individualized and have long-term effects. Specifically, attention is nowadays focused on the development of gene editing strategies, chiefly those based on CRISPR/Cas technology. Rare coagulopathies such as hemophilia A and B, or even ultra-rare ones such as factor V deficiency, could be among those deriving the greatest benefit from these new developments., Asociación para la Investigación y Cura del Déficit de Factor V, Universidad Complutense de Madrid, Banco Santander, Depto. de Genética, Fisiología y Microbiología, Fac. de Ciencias Biológicas, TRUE, pub, APC financiada por la UCM