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21. Development of a multivariable prediction model for congenital unilateral absence of the vas deferens in male partners of infertile couples.

Author

Brusq, Clara, Mieusset, Roger, and Hamdi, Safouane M.

Subjects
*MALE infertility, *VAS deferens, *CYSTIC fibrosis transmembrane conductance regulator, *RANDOM forest algorithms, *ENDORECTAL ultrasonography, *PREDICTION models
Abstract

Background: Congenital unilateral absence of vas deferens has been diagnosed in fertile and normozoospermic males and is associated with the risk of unilateral renal absence or cystic fibrosis transmembrane conductance regulator mutations; but no prediction model currently exists to diagnose this condition. Objectives: The study aims to identify clinical and biological variables that may have a predictive value for the diagnosis of congenital unilateral absence of vas deferens in male partners of infertile couples Materials and methods: We designed a retrospective, cross‐sectional, case‐control study on electronic health records of a single tertiary‐care andrological centre collected between 1998 and 2018. We included all subjects diagnosed with congenital unilateral absence of vas deferens using combined scrotal and transrectal ultrasounds. Controls were confirmed free of congenital unilateral absence of vas deferens by the same way. Both groups received standardised exploration procedures. Multivariable logistic regression model was built in a backward stepwise manner. Model performance and calibration were assessed. The study is reported according to TRIPOD statement. Results: We included 69 congenital unilateral absence of vas deferens cases and 78 controls. Cases had a lower semen volume than controls. The congenital unilateral absence of vas deferens risk was associated with history of cryptorchidism and both levels of semen fructose and α‐glucosidase. These predictors were confirmed by a random forest algorithm. The area under the curve was 0.886 (95% interval: 0.81–0.92). Calibration was performed with the Hosmer‐Lemeshow test (p = 0.88). Discussion and conclusion: History of cryptorchidism, semen fructose and α‐glucosidase were identified as relevant and independent predictors for the diagnosis of congenital unilateral absence of vas deferens. The model enables to identify male patients with a high risk of congenital unilateral absence of vas deferens to whom a transrectal ultrasounds would be proposed to confirm the diagnosis, whatever their semen parameters. It will also help to address the risks of unilateral renal absence and of cystic fibrosis transmembrane conductance regulator mutations carrying during the management of infertile couples. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Temperature and Testis

Author

Mieusset Roger

Subjects
Litter (animal), Infertility, endocrine system, Fetus, urogenital system, Varicocele, Embryogenesis, Biology, medicine.disease, Sperm, Andrology, medicine.anatomical_structure, medicine, reproductive and urinary physiology, Germ cell, Sperm motility
Abstract

In a thermoneutral environment the scrotal testes are appreciably cooler than the body, in mammals and humans, through specific physiological mechanisms. Experimental elevations of testicular temperature induce mainly germ cell alterations that result in reversible effects: reduction in sperm output, sperm motility and normal sperm morphology; reduction in litter size; increased embryonic death; smaller fetuses; abnormalities in embryonic development; and even an infertility period. Routes of potential exposure in humans are related to posture, clothing and activity, lifestyle factors, occupational heat exposure and clinical factors such as cryptorchidism and varicocele.

Published
2018

31. Are men ready to use thermal male contraception? Acceptability in two French populations: New fathers and new providers

Author

Amouroux, Marie, Mieusset, Roger, Desbriere, Raoul, Opinel, Pierre, Karsenty, Gilles, Paci, Marine, Fernandes, Sara, Courbiere, Blandine, Perrin, Jeanne, Département Universitaire de Médecine Générale, Faculté de Médecine de Marseille , Aix Marseille Université AMU, Centre de stérilité masculine, Service d'urologie-andrologie, Hôpital Paule de Viguier, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Service de Gynécologie-Obstétrique, Pôle Parents Enfants,Hôpital Saint-Joseph, Centre Hospitalier du Pays d'Aix, Chirurgie urologique et transplantation rénale [Hôpital de la Conception - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre Clinico-Biologique d’Assistance Médicale à la Procréation - CECOS [Hôpital de la Conception - APHM], Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Santé Publique, Aix Marseille Université (AMU), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, MESH: Body Temperature, Medical Doctors, Physiology, Health Care Providers, Maternal Health, lcsh:Medicine, Choice Behavior, Body Temperature, Fathers, Families, Pregnancy, MESH: Contraception/psychology, Medicine and Health Sciences, Medical Personnel, Reproductive System Procedures, lcsh:Science, Contraception Behavior, MESH: Contraception/methods, MESH: Middle Aged, Obstetrics and Gynecology, Middle Aged, Professions, Contraception, Physiological Parameters, MESH: Young Adult, Female, Research Article, Adult, MESH: Attitude, Parenting Behavior, Surgical and Invasive Medical Procedures, MESH: Choice Behavior, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction, Young Adult, MESH: Fathers/psychology, MESH: Cross-Sectional Studies, Physicians, Vasectomy, Humans, Female Contraception, MESH: Contraception Behavior, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Behavior, MESH: Humans, Surgical Excision, lcsh:R, Biology and Life Sciences, MESH: Adult, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, MESH: Male, Male Contraception, Health Care, Cross-Sectional Studies, Attitude, People and Places, Women's Health, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Population Groupings, MESH: Female
Abstract

International audience; BACKGROUND:Since the 1970s, international research has actively pursued hormonal male contraception (HMC) and, to a lesser extent, thermal male contraception (TMC). Although the efficacy of TMC has been confirmed in limited populations, its acceptability has not been studied in either potential users or potential prescribers.METHODS:A cross-sectional descriptive multicentre study of potential male users of TMC (new fathers) and potential prescribers of TMC (new providers) was conducted between November 2016 and February 2017.The participants completed a 3-part survey, and their responses were evaluated to i) determine their socio-demographic profiles; ii) identify personal experiences with contraception; and iii) gauge the participants' knowledge, interest and preference for male contraception, particularly TMC. For new providers only, the survey included a fourth part to evaluate professional experience with male contraception.RESULTS:The participation rate was 51% for new fathers (305 NFs) and 34% for new providers (300 NPs, including 97 men (male new providers, MNPs) and 203 women (female new providers, FNPs)). Only 3% of NFs and 15% of NPs knew about TMC (including 26% of the MNPs and 10% of the FNPs, p

Published
2017

34. COVID‐19 in men: With or without virus in semen, spermatogenesis may be impaired.

Author

Bendayan, Marion, Robin, Geoffroy, Hamdi, Safouane, Mieusset, Roger, and Boitrelle, Florence

Subjects
COVID-19, SEMEN, SERTOLI cells, SPERMATOGENESIS, MALE infertility, MALE reproductive organs, OLIGOSPERMIA
Abstract

COVID-19 in men: With or without virus in semen, spermatogenesis may be impaired Keywords: Covid-19; fever; SARS-CoV-2; semen; spermatogenesis EN Covid-19 fever SARS-CoV-2 semen spermatogenesis 1 3 3 01/28/21 20210201 NES 210201 Sir, We would like to congratulate you for the review recently published in Andrologia entitled "Could SARS-CoV-2 affect male fertility?" Even in cure patients, the presence of the virus in semen is not impossible, and apart from the presence of virus in semen, spermatogenesis can be impaired by COVID-19-related fever. [Extracted from the article]

Published
2021
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35. La contraception masculine

Author

SOUFIR Jean-Claude, MIEUSSET Roger, SOUFIR Jean-Claude, and MIEUSSET Roger

Subjects
Male contraceptives
Abstract

La contraception masculine est une pratique très ancienne, même si sa médicalisation est plus récente. Les enquêtes montrent que si «une pilule pour homme » existait, elle serait accueillie positivement par la majorité des hommes et des femmes. Cet ouvrage fait le point sur les différentes méthodes de contraception masculine. Il est constitué de textes rapportant les expériences françaises (hormonale, thermique) et la synthèse des expériences mondiales. Ces différentes méthodes font l'objet de débats, tant au plan médical (effets secondaires, efficacité) que sociétal, auxquels ce livre veut contribuer. Il apporte ainsi l'indispensable regard de psychologues et de sociologues à travers leurs enquêtes et leurs réflexions et montre que le choix contraceptif assumé par l'homme participe de la construction de l'identité masculine.

Published
2013

37. Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens

Author

Patat, Olivier, primary, Pagin, Adrien, additional, Siegfried, Aurore, additional, Mitchell, Valérie, additional, Chassaing, Nicolas, additional, Faguer, Stanislas, additional, Monteil, Laetitia, additional, Gaston, Véronique, additional, Bujan, Louis, additional, Courtade-Saïdi, Monique, additional, Marcelli, François, additional, Lalau, Guy, additional, Rigot, Jean-Marc, additional, Mieusset, Roger, additional, and Bieth, Eric, additional

Published
2016
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39. The spectrum of renal involvement in male patients with infertility related to excretory-system abnormalities: phenotypes, genotypes, and genetic counseling

Author

Mieusset, Roger, primary, Fauquet, Isabelle, additional, Chauveau, Dominique, additional, Monteil, Laetitia, additional, Chassaing, Nicolas, additional, Daudin, Myriam, additional, Huart, Antoine, additional, Isus, François, additional, Prouheze, Cathy, additional, Calvas, Patrick, additional, Bieth, Eric, additional, Bujan, Louis, additional, and Faguer, Stanislas, additional

Published
2016
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43. Donner et après... la procréation par don de spermatozoïdes avec ou sans anonymat ?

Author

JOUANNET Pierre, MIEUSSET Roger, JOUANNET Pierre, and MIEUSSET Roger

Subjects
Artificial insemination, Artificial insemination, Human--Social aspects
Abstract

Faut-il lever l'anonymat du don de sperme? La question se pose d'autant que plusieurs pays ont modifié leur législation en ce sens et que des enfants devenus adultes revendiquent avec force la possibilité de connaître l'identité de l'homme qui, en donnant son sperme, a permis à leurs parents de les concevoir. Malheureusement le débat reste souvent dans les registres émotionnel et compassionnel, sans réelle évaluation des programmes d'aide à la procréation par don de spermatozoïdes et sans véritable réflexion sur les enjeux et les conséquences des choix éthiques qui devront être faits. Cet ouvrage rend compte du vécu et du regard des équipes médicales et des psychologues qui aident les hommes et les femmes à devenir parents grâce à un don, et donne la parole à des philosophes et à différents spécialistes dans une approche transdisciplinaire. Enfin et surtout, les acteurs eux-mêmes sont présents, qu'ils soient parents, donneurs ou enfants, grâce à leurs très nombreux témoignages.

Published
2010

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