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It was established, that HPV virus (Human Papilloma Virus) is responsible for tumor induction in some anatomical regions of head and neck, mainly in palatine tonsils. The characteristics of HPV-related tumors as well as the course of the disease are definitely different compared to tobacco-smoking related tumors; patients HPV-positve have better prognosis - less patients develops recurrences and dies from the disease. There is no full compliance about patients' characteristics, although most indications concern "young adults" with their intensive sexual life. Because the course of HPV-related tumors is milder, there is a need to distinguish the cause of disease to carry on the therapy adjusted to the causative factor. This approach might help to select HPV-negative patients with severe course of disease to apply more aggressive chemotherapy.

Technique of the application of radioactive tracer to the primary tumor and lymphoscintigraphy with use of the stationary and handheld gamma probe was presented. Various types of the used radioactive tracers were characterized. Scintigraphical criteria for sentinel nodes recognition were discussed. Advantages and limitations of the use of lymphoscintigraphy for sentinel nodes detection were described. Necessity of further study to determine feasibility of sentinel nodes radiolocalization in stage N0 in head and neck cancer was pointed out.

Aim of the Study: The evaluation of the importance of the prognostic of sentinel node biopsy in head and neck cancer with N0 neck., Material and Methods: Prospective study included 19 patients with squamous cell carcinoma of the oral cavity, pharynx and larynx without enlarged lymph nodes in ultrasound examination (N0). The study was carried out in ENT Department of Medical University in Poznań between 2001-2004. Each patient underwent lymphoscintigraphy after administration of radionuclide Technetium 99m (Nanocol). In case of detection of sentinel node, blue dye was injected into the tumour bed and dyed lymph nodes were removed. The specimens were evaluated histologically and immunohistochemically. The patients are still followed up., Results: So far 19 patients were included in our study. The tumours were classified from T1 to T4. In each case sentinel nodes were located. Metastases in removed lymphnodes were found in 5 patients. In one of them regional recidive was observed after 5 month. In the other patients no changes were found in follow up examination. In 14 cases in histological examination no metastases were found in sentinel nodes. In this group in one case local recurrence was observed and in another two lymph nodes metastases were confirmed. In patients with positive sentinel node elective neck dissection was performed. So far immunohistochemical examination has not provided us with any vital information. In no case with negative sentinel node we found micrometastases with the use of cytokeratin., Conclusions: Based on our preliminary observation of the patients we have found that there is certain correlation confirming the fact that sentinel node may be reliable for the whole neck lymphatic system. Further clinical observation are needed based on a larger number of patients and longer observation period.

The aim of the study was to appraise the level of interleukin 5, 8 in secretion from the nose in etiology of chronic inflammatory state of the nose and nasal sinuses. The group of 32 patients classified as group suffered from the inflammatory state of nasal sinuses described in the International Nose and sinuses Conference in Princeton, New Jersey 1993 was examined. The level of IL-5 and IL-8 with ELISA method was indicated and the cytological examination was carried out. In the material a predominance of neutrophils implying a bacterial etiology of illness was observed. Simultaneously the high level of IL 8 (13-1393 average 2.7 +/- 6.1) was indicated.