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1. Viral Determinants of Acute COVID-19 Symptoms in a Nonhospitalized Adult Population in the Pre-Omicron Era

Author

Goldberg, Sarah A, Lu, Scott, Garcia-Knight, Miguel, Davidson, Michelle C, Tassetto, Michel, Anglin, Khamal, Pineda-Ramirez, Jesus, Chen, Jessica Y, Rugart, Paulina R, Mathur, Sujata, Forman, Carrie A, Donohue, Kevin C, Abedi, Glen R, Saydah, Sharon, Briggs-Hagen, Melissa, Midgley, Claire M, Andino, Raul, Peluso, Michael J, Glidden, David V, Martin, Jeffrey N, and Kelly, J Daniel

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Emerging Infectious Diseases, Vaccine Related, Clinical Research, Biodefense, Lung, Pneumonia & Influenza, Genetics, Infectious Diseases, Prevention, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Clinical sciences, Medical microbiology
Abstract

BackgroundThe influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA level and presence of infectious virus on symptom occurrence is poorly understood, particularly among nonhospitalized individuals.MethodsThe study included 85 nonhospitalized, symptomatic adults, who were enrolled from September 2020 to November 2021. Data from a longitudinal cohort studied over 28 days was used to analyze the association of individual symptoms with SARS-CoV-2 viral RNA load, or the presence or level of infectious (culturable) virus. Presence of infectious virus and viral RNA load were assessed daily, depending on specimen availability, and amount of infectious virus was assessed on the day of maximum RNA load. Participants were surveyed for the start and end dates of 31 symptoms at enrollment and at days 9, 14, 21, and 28; daily symptom presence was determined analytically. We describe symptoms and investigate their possible association with viral determinants through a series of single or pooled (multiple days across acute period) cross-sectional analyses.ResultsThere was an association between viral RNA load and the same-day presence of many individual symptoms. Additionally, individuals with infectious virus were more than three times as likely to have a concurrent fever than individuals without infectious virus, and more than two times as likely to have concurrent myalgia, chills, headache, or sore throat.ConclusionsWe found evidence to support the association of viral RNA load and infectious virus on some, but not all symptoms. Fever was most strongly associated with the presence of infectious virus; this may support the potential for symptom-based isolation guidance for COVID-19.

Published
2023

2. Early biological markers of post-acute sequelae of SARS-CoV-2 infection

Author

Lu, Scott, Peluso, Michael J., Glidden, David V., Davidson, Michelle C., Lugtu, Kara, Pineda-Ramirez, Jesus, Tassetto, Michel, Garcia-Knight, Miguel, Zhang, Amethyst, Goldberg, Sarah A., Chen, Jessica Y., Fortes-Cobby, Maya, Park, Sara, Martinez, Ana, So, Matthew, Donovan, Aidan, Viswanathan, Badri, Hoh, Rebecca, Donohue, Kevin, McIlwain, David R., Gaudiliere, Brice, Anglin, Khamal, Yee, Brandon C., Chenna, Ahmed, Winslow, John W., Petropoulos, Christos J., Deeks, Steven G., Briggs-Hagen, Melissa, Andino, Raul, Midgley, Claire M., Martin, Jeffrey N., Saydah, Sharon, and Kelly, J. Daniel

Published
2024
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4. Association of Culturable-Virus Detection and Household Transmission of SARS-CoV-2, California and Tennessee, 2020-2022.

Author

Deyoe, Jessica E, Kelly, J Daniel, Grijalva, Carlos G, Bonenfant, Gaston, Lu, Scott, Anglin, Khamal, Garcia-Knight, Miguel, Pineda-Ramirez, Jesus, Hagen, Melissa Briggs, Saydah, Sharon, Abedi, Glen R, Goldberg, Sarah A, Tassetto, Michel, Zhang, Amethyst, Donohue, Kevin C, Davidson, Michelle C, Sanchez, Ruth Diaz, Djomaleu, Manuella, Mathur, Sujata, Shak, Joshua R, Deeks, Steven G, Peluso, Michael J, Chiu, Charles Y, Zhu, Yuwei, Halasa, Natasha B, Chappell, James D, Mellis, Alexandra, Reed, Carrie, Andino, Raul, Martin, Jeffrey N, Zhou, Bin, Talbot, H Keipp, Midgley, Claire M, and Rolfes, Melissa A

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Lung, Emerging Infectious Diseases, Biodefense, Prevention, Vaccine Related, Infectious Diseases, Infection, Humans, SARS-CoV-2, COVID-19, Tennessee, Family Characteristics, California, household transmission, secondary infection risk, viral culture, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

From 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission studies (enrolling April 2020 to January 2022) with rapid enrollment and specimen collection for 14 days, 61% (43/70) of primary cases had culturable virus detected ≥6 days post-onset. Risk of secondary infection among household contacts tended to be greater when primary cases had culturable virus detected after onset. Regardless of duration of culturable virus, most secondary infections (70%, 28/40) had serial intervals

Published
2023

5. Magnitude and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Household Transmission: A Longitudinal Cohort Study

Author

Kelly, J Daniel, Lu, Scott, Anglin, Khamal, Garcia-Knight, Miguel, Pineda-Ramirez, Jesus, Goldberg, Sarah A, Tassetto, Michel, Zhang, Amethyst, Donohue, Kevin, Davidson, Michelle C, Romero, Mariela, Diaz Sanchez, Ruth, Djomaleu, Manuella, Mathur, Sujata, Chen, Jessica Y, Forman, Carrie A, Servellita, Venice, Montejano, Rubi D, Shak, Joshua R, Rutherford, George W, Deeks, Steven G, Abedi, Glen R, Rolfes, Melissa A, Saydah, Sharon, Briggs-Hagen, Melissa, Peluso, Michael J, Chiu, Charles, Midgley, Claire M, Andino, Raul, and Martin, Jeffrey N

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Vaccine Related, Infectious Diseases, Pneumonia, Immunization, Biodefense, Lung, Emerging Infectious Diseases, Prevention, Infection, Good Health and Well Being, COVID-19, Cohort Studies, Humans, Longitudinal Studies, RNA, SARS-CoV-2, household transmission, epidemiology, infectious viral shedding, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundHouseholds have emerged as important venues for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Little is known, however, regarding the magnitude and determinants of household transmission in increasingly vaccinated populations.MethodsFrom September 2020 to January 2022, symptomatic nonhospitalized individuals with SARS-CoV-2 infection by RNA detection were identified within 5 days of symptom onset; all individuals resided with at least 1 other SARS-CoV-2-uninfected household member. These infected persons (cases) and their household members (contacts) were subsequently followed with questionnaire-based measurement and serial nasal specimen collection. The primary outcome was SARS-CoV-2 infection among contacts.ResultsWe evaluated 42 cases and their 74 household contacts. Among the contacts, 32 (43%) became infected, of whom 5 (16%) were asymptomatic; 81% of transmissions occurred by 5 days after the case's symptom onset. From 21 unvaccinated cases, 14-day cumulative incidence of SARS-CoV-2 infection among contacts was 18/40 (45% [95% confidence interval {CI}, 29%-62%]), most of whom were unvaccinated. From 21 vaccinated cases, 14-day cumulative incidence of SARS-CoV-2 infection was 14/34 (41% [95% CI, 25%-59%]) among all contacts and 12/29 (41% [95% CI, 24%-61%]) among vaccinated contacts. At least 1 comorbid condition among cases and 10 or more days of RNA detection in cases were associated with increased risk of infection among contacts.ConclusionsAmong households including individuals with symptomatic SARS-CoV-2 infection, both vaccinated-to-vaccinated and unvaccinated-to-unvaccinated transmission of SARS-CoV-2 to household contacts was common. Because vaccination alone did not notably reduce risk of infection, household contacts will need to employ additional interventions to avoid infection.

Published
2022

7. Prevalence, Patterns, and Predictors of SARS-CoV-2 RNA and Culturable Virus in Tears of a Case-Ascertained Household Cohort

Author

SO, MATTHEW, GOLDBERG, SARAH A., LU, SCOTT, GARCIA-KNIGHT, MIGUEL, DAVIDSON, MICHELLE C., TASSETTO, MICHEL, MURRAY, VICTORIA WONG, ANGLIN, KHAMAL, PINEDA-RAMIREZ, JESUS, CHEN, JESSICA Y., RUGART, PAULINA R., RICHARDSON, EUGENE T., BRIGGS-HAGEN, MELISSA, MIDGLEY, CLAIRE M., ANDINO, RAUL, SEITZMAN, GERAMI D., GONZALES, JOHN, PELUSO, MICHAEL J., MARTIN, JEFFREY N., and KELLY, JOHN DANIEL

Published
2024
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8. Detection of Higher Cycle Threshold Values in Culturable SARS-CoV-2 Omicron BA.1 Sublineage Compared with Pre-Omicron Variant Specimens — San Francisco Bay Area, California, July 2021—March 2022

Author

Tassetto, Michel, Garcia-Knight, Miguel, Anglin, Khamal, Lu, Scott, Zhang, Amethyst, Romero, Mariela, Pineda-Ramirez, Jesus, Sanchez, Ruth Diaz, Donohue, Kevin C, Pfister, Karen, Chan, Curtis, Saydah, Sharon, Briggs-Hagen, Melissa, Peluso, Michael J, Martin, Jeffrey N, Andino, Raul, Midgley, Claire M, and Kelly, J Daniel

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Lung, Vaccine Related, Biodefense, Prevention, Infectious Diseases, Emerging Infectious Diseases, Infection, Good Health and Well Being, COVID-19, Humans, RNA, Viral, Reproducibility of Results, SARS-CoV-2, San Francisco, General & Internal Medicine
Abstract

Before emergence in late 2021 of the highly transmissible B.1.1.529 (Omicron) variant of SARS-CoV-2, the virus that causes COVID-19 (1,2), several studies demonstrated that SARS-CoV-2 was unlikely to be cultured from specimens with high cycle threshold (Ct) values§ from real-time reverse transcription-polymerase chain reaction (RT-PCR) tests (suggesting low viral RNA levels) (3). Although CDC and others do not recommend attempting to correlate Ct values with the amount of infectious virus in the original specimen (4,5), low Ct values are sometimes used as surrogate markers for infectiousness in clinical, public health, or research settings without access to virus culture (5). However, the consistency in reliability of this practice across SARS-CoV-2 variants remains uncertain because Omicron-specific data on infectious virus shedding, including its relationship with RNA levels, are limited. In the current analysis, nasal specimens collected from an ongoing longitudinal cohort¶ (6,7) of nonhospitalized participants with positive SARS-CoV-2 test results living in the San Francisco Bay Area** were used to generate Ct values and assess for the presence of culturable SARS-CoV-2 virus; findings were compared between specimens from participants infected with pre-Omicron variants and those infected with the Omicron BA.1 sublineage. Among specimens with culturable virus detected, Ct values were higher (suggesting lower RNA levels) during Omicron BA.1 infections than during pre-Omicron infections, suggesting variant-specific differences in viral dynamics. Supporting CDC guidance, these data show that Ct values likely do not provide a consistent proxy for infectiousness across SARS-CoV-2 variants.

Published
2022

9. Risk Factors for Reinfection with SARS-CoV-2 Omicron Variant among Previously Infected Frontline Workers

Author

Ellingson, Katherine D., Hollister, James, Porter, Cynthia J., Khan, Sana M., Feldstein, Leora R., Naleway, Allison L., Gaglani, Manjusha, Caban-Martinez, Alberto J., Tyner, Harmony L., Lowe, Ashley A., Olsho, Lauren E.W., Meece, Jennifer, Yoon, Sarang K., Mak, Josephine, Kuntz, Jennifer L., Solle, Natasha Schaefer, Respet, Karley, Baccam, Zoe, Wesley, Meredith G., Thiese, Matthew S., Yoo, Young M., Odean, Marilyn J., Miiro, Flavia N., Pickett, Steve L., Phillips, Andrew L., Grant, Lauren, Romine, James K., Herring, Meghan K., Hegmann, Kurt T., Lamberte, Julie Mayo, Sokol, Brian, Jovel, Krystal S., Thompson, Mark G., Rivers, Patrick, Pilishvili, Tamara, Lutrick, Karen, Burgess, Jefferey L., Midgley, Claire M., and Fowlkes, Ashley L.

Subjects
Diseases -- Relapse, Medical personnel -- Statistics -- Health aspects, Health
Abstract

Essential and frontline workers experience repeated occupational exposure to SARS-CoV-2 (1). The variant B.1.1.529 (Omicron) is characterized by unprecedented transmissibility and potential for immune evasion, which led to a surge [...]

Published
2023
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10. The kinetics and durability of antibody and T-cell responses to SARS-CoV-2 in children

Author

Files, Megan A, primary, Gentles, Lauren, additional, Kehoe, Leanne, additional, Adler, Amanda, additional, Lacombe, Kirsten, additional, Dickerson, Jane A, additional, Greninger, Alexander, additional, Waghmare, Alpana, additional, Fairlie, Tarayn, additional, Pringle, Kimberly, additional, Midgley, Claire M, additional, Hagen, Melissa Briggs, additional, Englund, Janet A, additional, and Seshadri, Chetan, additional

Published
2024
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11. The role and limitations of electronic medical records versus patient interviews for determining symptoms, underlying comorbidities, and medication usage for patients with COVID-19

Author

Soto, Raymond A, primary, Vahey, Grace M, additional, Marshall, Kristen E, additional, McDonald, Emily, additional, Herlihy, Rachel, additional, Chun, Helen M, additional, Killerby, Marie E, additional, Kawasaki, Breanna, additional, Midgley, Claire M, additional, Alden, Nisha B, additional, Tate, Jacqueline E, additional, Staples, J Erin, additional, and Investigation Team, Colorado, additional

Published
2024
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12. Prevalence, patterns, and predictors of SARS-CoV-2 RNA and culturable virus in tears of case-ascertained household cohort

Author

So, Matthew, primary, Goldberg, Sarah A., additional, Lu, Scott, additional, Garcia-Knight, Miguel, additional, Davidson, Michelle C., additional, Tassetto, Michel, additional, Murray, Victoria Wong, additional, Anglin, Khamal, additional, Pineda-Ramirez, Jesus, additional, Chen, Jessica Y., additional, Rugart, Paulina R., additional, Richardson, Eugene T., additional, Hagen, Melissa Briggs, additional, Midgley, Claire M., additional, Andino, Raul, additional, Seitzman, Gerami D., additional, Gonzales, John, additional, Peluso, Michael J., additional, Martin, Jeffrey N., additional, and Kelly, J. Daniel, additional

Published
2024
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13. Lack of Serologic Evidence of Infection Among Health Care Personnel and Other Contacts of First 2 Confirmed Patients With COVID-19 in Illinois, 2020

Author

McPherson, Tristan D., Ghinai, Isaac, Binder, Alison M., Freeman, Brandi D., Snelling, Chantel Hoskin, Hunter, Jennifer C., Anderson, Kristin M., Davenport, Polly, Rudd, Deborah L., Zafer, Mujeeb, Christiansen, Demian, Joshi, Kiran, Rubin, Rachel, Black, Stephanie R., Fricchione, Marielle J., Pacilli, Massimo, Walblay, Kelly A., Korpics, Jacqueline, Moeller, Darcie, Quartey-Kumapley, Pearl, Wang, Chen, Charles, E. Matt, Kauerauf, Judy, Patel, Megan T., Disari, Vishal S., Fischer, Marc, Jacobs, Max W., Lester, Sandra N., Midgley, Claire M., Rasheed, Mohammed Ata Ur, Reese, Heather E., Verani, Jennifer R., Wallace, Megan, Watson, John T., Thornburg, Natalie J., Layden, Jennifer E., and Kirking, Hannah L.

Published
2021

14. Effectiveness of Bivalent mRNA COVID-19 Vaccines in Preventing SARS-CoV-2 Infection in Children and Adolescents Aged 5 to 17 Years

Author

Feldstein, Leora R., primary, Britton, Amadea, additional, Grant, Lauren, additional, Wiegand, Ryan, additional, Ruffin, Jasmine, additional, Babu, Tara M., additional, Briggs Hagen, Melissa, additional, Burgess, Jefferey L., additional, Caban-Martinez, Alberto J., additional, Chu, Helen Y., additional, Ellingson, Katherine D., additional, Englund, Janet A., additional, Hegmann, Kurt T., additional, Jeddy, Zuha, additional, Lauring, Adam S., additional, Lutrick, Karen, additional, Martin, Emily T., additional, Mathenge, Clare, additional, Meece, Jennifer, additional, Midgley, Claire M., additional, Monto, Arnold S., additional, Newes-Adeyi, Gabriella, additional, Odame-Bamfo, Leah, additional, Olsho, Lauren E. W., additional, Phillips, Andrew L., additional, Rai, Ramona P., additional, Saydah, Sharon, additional, Smith, Ning, additional, Steinhardt, Laura, additional, Tyner, Harmony, additional, Vandermeer, Meredith, additional, Vaughan, Molly, additional, Yoon, Sarang K., additional, Gaglani, Manjusha, additional, and Naleway, Allison L., additional

Published
2024
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15. Changes in influenza and other respiratory virus activity during the COVID-19 pandemic—United States, 2020–2021

Author

Olsen, Sonja J., Winn, Amber K., Budd, Alicia P., Prill, Mila M., Steel, John, Midgley, Claire M., Kniss, Krista, Burns, Erin, Rowe, Thomas, Foust, Angela, Jasso, Gabriela, Merced-Morales, Angiezel, Davis, C. Todd, Jang, Yunho, Jones, Joyce, Daly, Peter, Gubareva, Larisa, Barnes, John, Kondor, Rebecca, Sessions, Wendy, Smith, Catherine, Wentworth, David E., Garg, Shikha, Havers, Fiona P., Fry, Alicia M., Hall, Aron J., Brammer, Lynnette, and Silk, Benjamin J.

Published
2021
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16. Patterns of Virus Exposure and Presumed Household Transmission among Persons with Coronavirus Disease, United States, January--April 2020

Author

Burke, Rachel M., Calderwood, Laura, Killerby, Marie E., Ashworth, Candace E., Berns, Abby L., Brennan, Skyler, Bressler, Jonathan M., Morano, Laurel Harduar, Lewis, Nathaniel M., Markus, Tiffanie M., Newton, Suzanne M., Read, Jennifer S., Rissman, Tamara, Taylor, Joanne, Tate, Jacqueline E., and Midgley, Claire M.

Subjects
Households -- Statistics -- Health aspects, Disease transmission -- Statistics -- Risk factors, Health
Abstract

Coronavirus disease (COVID-19) was first identified in Wuhan, China, in December 2019 (1). The first reported case in the United States was identified in January 2020 (2); by mid-March, cases [...]

Published
2021
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19. Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020

Author

CDC COVID-19 Response Clinical Team, Killerby, Marie E., Link-Gelles, Ruth, Haight, Sarah C., Schrodt, Caroline A., England, Lucinda, Gomes, Danica J., Shamout, Mays, Pettrone, Kristen, O’Laughlin, Kevin, Kimball, Anne, Blau, Erin F., Burnett, Eleanor, Ladva, Chandresh N., Szablewski, Christine M., Tobin-D’Angelo, Melissa, Oosmanally, Nadine, Drenzek, Cherie, Murphy, David J., Blum, James M., Hollberg, Julie, Lefkove, Benjamin, Brown, Frank W., Shimabukuro, Tom, Midgley, Claire M., and Tate, Jacqueline E.

Published
2020

21. Characteristics and Risk Factors of Hospitalized and Nonhospitalized COVID-19 Patients, Atlanta, Georgia, USA, March-April 2020

Author

Pettrone, Kristen, Burnett, Eleanor, Link-Gelles, Ruth, Haight, Sarah C., Schrodt, Caroline, England, Lucinda, Gomes, Danica J., Shamout, Mays, O'Laughlin, Kevin, Kimball, Anne, Blau, Erin F., Ladva, Chandresh N., Szablewski, Christine M., Tobin-DAngelo, Melissa, Oosmanally, Nadine, Drenzek, Cherie, Browning, Sean D., Bruce, Beau B., Silva, Juliana da, Gold, Jeremy A.W., Jackson, Brendan R., Morris, Sapna Bamrah, Natarajan, Pavithra, Fanfair, Robyn Neblett, Patel, Priti R., Rogers- Brown, Jessica, Rossow, John, Wong, Karen K., Murphy, David J., Blum, James M., Hollberg, Julie, Lefkove, Benjamin, Brown, Frank W., Shimabukuro, Tom, Midgley, Claire M., Tate, Jacqueline E., and Killerby, Marie E.

Subjects
Epidemics -- Risk factors -- Patient outcomes -- Demographic aspects -- United States, Health
Abstract

Information about care-seeking behavior, symptom duration, and risk factors for progression to severe illness in nonhospitalized patients with coronavirus disease (COVID-19) aids in resource planning, disease identification, risk stratification, and [...]

Published
2021
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22. Symptom Profiles and Progression in Hospitalized and Nonhospitalized Patients with Coronavirus Disease, Colorado, USA, 2020

Author

Vahey, Grace M., Marshall, Kristen E., McDonald, Emily, Martin, Stacey W., Tate, Jacqueline E., Midgley, Claire M., Killerby, Marie E., Kawasaki, Breanna, Herlihy, Rachel K., Alden, Nisha B., and Staples, J. Erin

Subjects
Epidemics -- Control -- United States, Prevalence studies (Epidemiology) -- Management, Public health administration -- Evaluation, Company business management, Health
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), was first detected in China in December 2019 (2,2). Within 1 month, COVID-19 cases were reported [...]

Published
2021
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23. ClinSeqSer: Clinical and laboratory characteristics of patients hospitalized with severe COVID-19—New Orleans, August 2020–September 2021

Author

Drouin, Arnaud, primary, Plumb, Ian D., additional, McCullough, Matthew, additional, James-Gist, Jade, additional, Liu, Sharon, additional, Theberge, Marc, additional, Katz, Joshua, additional, Moreida, Matthew, additional, Flaherty, Shelby, additional, Chatwani, Bhoomija, additional, Briggs-Hagen, Melissa, additional, Midgley, Claire M., additional, and Fusco, Dahlene, additional

Published
2023
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24. Enterovirus D68–Associated Acute Respiratory Illness — New Vaccine Surveillance Network, United States, July–October, 2017 and 2018

Author

Kujawski, Stephanie A., Midgley, Claire M., Rha, Brian, Lively, Joana Y., Nix, W. Allan, Curns, Aaron T., Payne, Daniel C., Englund, Janet A., Boom, Julie A., Williams, John V., Weinberg, Geoffrey A., Staat, Mary A., Selvarangan, Rangaraj, Halasa, Natasha B., Klein, Eileen J., Sahni, Leila C., Michaels, Marian G., Shelley, Lynne, McNeal, Monica, Harrison, Christopher J., Stewart, Laura S., Lopez, Adriana S., Routh, Janell A., Patel, Manisha, Oberste, M. Steven, Watson, John T., and Gerber, Susan I.

Published
2019

25. Trends in Laboratory-Confirmed SARS-CoV-2 Reinfections and Associated Hospitalizations and Deaths Among Adults Aged [greater than or equal to]18 Years--18 U.S. Jurisdictions, September 2021-December 2022

Author

Ma, Kevin C., Dorabawila, Vajeera, Leon, Tomas M., Henry, Hannah, Johnson, Amelia G., Rosenberg, Eli, Mansfield, Joshua A., Midgley, Claire M., Plumb, Ian D., Aiken, Julia, Khanani, Quratul Ain, Auche, Steven, Bayoumi, Nagla S., Bennett, Sarah A., Bernu, Carmen, Chang, Carolyn, Como-Sabetti, Kathryn J., Cueto, Kevin, Cunningham, Spencer, Eddy, Meredith, Falender, Rebecca A., Fleischauer, Aaron, Frank, Darren M., Harrington, Pauline, Hoskins, Mikhail, Howsare, Adam, Ingaiza, Lucy M., Islam, Aras S., Jensen, Shelli A., Jones, Jefferson M., Kambach, Grace, Kanishka, F.N.U., Levin, Yuriy, Masarik, John F., III, Meyer, Stephanie D., Milroy, Lauren, Morris, Keeley J., Olmstead, John, Olsen, Nina S., Omoike, Enaholo, Patel, Komal, Pettinger, Amanda, Pike, Melissa A., Reed, Isaiah G., Slocum, Elizabeth, Sutton, Melissa, Tilakaratne, Buddhi P., Vest, Hailey, Vostok, Johanna, Wang, Jennifer S., Watson-Lewis, Lydia, Wienkes, Haley N., Hagen, Melissa Briggs, Silk, Benjamin J., and Scobie, Heather M.

Subjects
Jurisdiction -- Health aspects, Infection -- Health aspects, Adults -- Health aspects, Health
Abstract

Although reinfections with SARS-CoV-2 have occurred in the United States with increasing frequency, U.S. epidemiologic trends in reinfections and associated severe outcomes have not been characterized. Weekly counts of SARS-CoV-2 [...]

Published
2023

26. Investigation and Serologic Follow-Up of Contacts of Early Confirmed Case-Patient with COVID-19, Washington, USA

Author

Chu, Victoria T., Freeman-Ponder, Brandi, Lindquist, Scott, Spitters, Christopher, Kawakami, Vance, Dyal, Jonathan W., Clark, Shauna, Bruce, Hollianne, Duchin, Jeffrey S., DeBolt, Chas, Podczervinski, Sara, D'Angeli, Marisa, Pettrone, Kristen, Zacks, Rachael, Vahey, Grace, Holshue, Michelle L., Lang, Misty, Burke, Rachel M., Rolfes, Melissa A., Marlow, Mariel, Midgley, Claire M., Lu, Xiaoyan, Lindstrom, Stephen, Hall, Aron J., Fry, Alicia M., Thornburg, Natalie J., Gerber, Susan I., Pillai, Satish K., and Biggs, Holly M.

Subjects
Severe acute respiratory syndrome -- Health aspects, Enzyme-linked immunosorbent assay -- Health aspects, Coronaviruses -- Health aspects, Type 2 diabetes -- Health aspects, COVID-19 -- Health aspects, Health
Abstract

In December 2019, a viral pneumonia outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, before spreading rapidly to other provinces in China and then [...]

Published
2020
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27. Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Author

Kujawski, Stephanie A., Wong, Karen K., Collins, Jennifer P., Epstein, Lauren, Killerby, Marie E., Midgley, Claire M., and Abedi, Glen R.

Subjects
Biological sciences, Health
Abstract

Data on the detailed clinical progression of COVID-19 in conjunction with epidemiological and virological characteristics are limited. In this case series, we describe the first 12 US patients confirmed to have COVID-19 from 20 January to 5 February 2020, including 4 patients described previously.sup.1-3. Respiratory, stool, serum and urine specimens were submitted for SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) testing, viral culture and whole genome sequencing. Median age was 53 years (range: 21-68); 8 patients were male. Common symptoms at illness onset were cough (n = 8) and fever (n = 7). Patients had mild to moderately severe illness; seven were hospitalized and demonstrated clinical or laboratory signs of worsening during the second week of illness. No patients required mechanical ventilation and all recovered. All had SARS-CoV-2 RNA detected in respiratory specimens, typically for 2-3 weeks after illness onset. Lowest real-time PCR with reverse transcription cycle threshold values in the upper respiratory tract were often detected in the first week and SARS-CoV-2 was cultured from early respiratory specimens. These data provide insight into the natural history of SARS-CoV-2. Although infectiousness is unclear, highest viral RNA levels were identified in the first week of illness. Clinicians should anticipate that some patients may worsen in the second week of illness. Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention., Author(s): Stephanie A. Kujawski [sup.1] [sup.1] , Karen K. Wong [sup.1] , Jennifer P. Collins [sup.1] , Lauren Epstein [sup.1] , Marie E. Killerby [sup.1] , Claire M. Midgley [sup.1] [...]

Published
2020
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28. Middle East Respiratory Syndrome Coronavirus Transmission

Author

Killerby, Marie E., Biggs, Holly M., Midgley, Claire M., Gerber, Susan I., and Watson, John T.

Subjects
Diseases -- Middle East -- Saudi Arabia -- United Arab Emirates, Middle East respiratory syndrome, Disease transmission, Backup software, Infection, Public health, Respiratory tract diseases, Public health movements, Health, World Health Organization
Abstract

Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) was first detected in Saudi Arabia in 2012 (1). To date, >2,400 cases globally have been reported to the World Health Organization (WHO), [...]

Published
2020
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29. Longitudinal and quantitative fecal shedding dynamics of SARS-CoV-2, pepper mild mottle virus, and crAssphage

Author

Arts, Peter J., primary, Kelly, J. Daniel, additional, Midgley, Claire M., additional, Anglin, Khamal, additional, Lu, Scott, additional, Abedi, Glen R., additional, Andino, Raul, additional, Bakker, Kevin M., additional, Banman, Bryon, additional, Boehm, Alexandria B., additional, Briggs-Hagen, Melissa, additional, Brouwer, Andrew F., additional, Davidson, Michelle C., additional, Eisenberg, Marisa C., additional, Garcia-Knight, Miguel, additional, Knight, Sterling, additional, Peluso, Michael J., additional, Pineda-Ramirez, Jesus, additional, Diaz Sanchez, Ruth, additional, Saydah, Sharon, additional, Tassetto, Michel, additional, Martin, Jeffrey N., additional, and Wigginton, Krista R., additional

Published
2023
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30. CASCADIA: a prospective community-based study protocol for assessing SARS-CoV-2 vaccine effectiveness in children and adults using a remote nasal swab collection and web-based survey design

Author

Babu, Tara M, primary, Feldstein, Leora R, additional, Saydah, Sharon, additional, Acker, Zachary, additional, Boisvert, Cassandra L, additional, Briggs-Hagen, Melissa, additional, Carone, Marco, additional, Casto, Amanda, additional, Cox, Sarah N, additional, Ehmen, Brenna, additional, Englund, Janet A, additional, Fortmann, Stephen P, additional, Frivold, Collrane J, additional, Groom, Holly, additional, Han, Peter D, additional, Kuntz, Jennifer L, additional, Lockwood, Tina, additional, Midgley, Claire M, additional, Mularski, Richard A, additional, Ogilvie, Tara, additional, Reich, Sacha L, additional, Schmidt, Mark A, additional, Smith, Ning, additional, Starita, Lea, additional, Stone, Jeremy, additional, Vandermeer, Meredith, additional, Weil, Ana A, additional, Wolf, Caitlin R, additional, Chu, Helen Y, additional, and Naleway, Allison L, additional

Published
2023
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32. Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia

Author

Abdely, Hail M. Al-, Midgley, Claire M., Alkhamis, Abdulrahim M., Abedi, Glen R., Lu, Xiaoyan, Binder, Alison M., Alanazi, Khalid H., Tamin, Azaibi, Banjar, Weam M., Lester, Sandra, Abdalla, Osman, Dahl, Rebecca M., Mohammed, Mutaz, Trivedi, Suvang, Algarni, Homoud S., Sakthivel, Senthilkumar K., Algwizani, Abdullah, Bafaqeeh, Fahad, Alzahrani, Abdullah, Alsharef, Ali Abraheem, Alhakeem, Raafat F., Jokhdar, Hani A. Aziz, Ghazal, Sameeh S., Thornburg, Natalie J., Erdman, Dean D., Assiri, Abdullah M., Watson, John T., and Gerber, Susan I.

Subjects
United States. Centers for Disease Control and Prevention, Mortality -- Middle East -- Saudi Arabia, Middle East respiratory syndrome -- Development and progression -- Health aspects, Medical research -- Health aspects, Antibodies -- Health aspects, RNA -- Health aspects, Therapeutics, Polymerase chain reaction, Health
Abstract

Infection with Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) results in a wide range of clinical manifestations, from mild or asymptomatic illness to severe respiratory failure (1-8); infection has a [...]

Published
2019
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33. Increase in Acute Respiratory Illnesses Among Children and Adolescents Associated with Rhinoviruses and Enteroviruses, Including Enterovirus D68-United States, July-September 2022

Author

Ma, Kevin C., Winn, Amber, Moline, Heidi L., Scobie, Heather M., Midgley, Claire M., Kirking, Hannah L., Adjemian, Jennifer, Hartnett, Kathleen P., Johns, Dylan, Jones, Jefferson M., Lopez, Adriana, Lu, Xiaoyan, Perez, Ariana, Perrine, Cria G., Rzucidlo, Andzelika E., McMorrow, Meredith L., Silk, Benjamin J., Stein, Zachary, Vega, Everardo, and Hall, Aron J.

Subjects
Children -- Diseases, Respiratory tract diseases, Health
Abstract

On September 27, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). Increases in severe respiratory illness and acute flaccid myelitis (AFM) among children [...]

Published
2022

37. Trends in Laboratory-Confirmed SARS-CoV-2 Reinfections and Associated Hospitalizations and Deaths Among Adults Aged ≥18 Years — 18 U.S. Jurisdictions, September 2021–December 2022

Author

Ma, Kevin C., primary, Dorabawila, Vajeera, additional, León, Tomás M., additional, Henry, Hannah, additional, Johnson, Amelia G., additional, Rosenberg, Eli, additional, Mansfield, Joshua A., additional, Midgley, Claire M., additional, Plumb, Ian D., additional, Aiken, Julia, additional, Khanani, Quratul Ain, additional, Auche, Steven, additional, Bayoumi, Nagla S., additional, Bennett, Sarah A., additional, Bernu, Carmen, additional, Chang, Carolyn, additional, Como-Sabetti, Kathryn J., additional, Cueto, Kevin, additional, Cunningham, Spencer, additional, Eddy, Meredith, additional, Falender, Rebecca A., additional, Fleischauer, Aaron, additional, Frank, Darren M., additional, Harrington, Pauline, additional, Hoskins, Mikhail, additional, Howsare, Adam, additional, Ingaiza, Lucy M., additional, Islam, Aras S., additional, Jensen, Shelli A., additional, Jones, Jefferson M., additional, Kambach, Grace, additional, Kanishka, FNU, additional, Levin, Yuriy, additional, Masarik, John F., additional, Meyer, Stephanie D., additional, Milroy, Lauren, additional, Morris, Keeley J., additional, Olmstead, John, additional, Olsen, Nina S., additional, Omoike, Enaholo, additional, Patel, Komal, additional, Pettinger, Amanda, additional, Pike, Melissa A., additional, Reed, Isaiah G., additional, Slocum, Elizabeth, additional, Sutton, Melissa, additional, Tilakaratne, Buddhi P., additional, Vest, Hailey, additional, Vostok, Johanna, additional, Wang, Jennifer S., additional, Watson-Lewis, Lydia, additional, Wienkes, Haley N., additional, Hagen, Melissa Briggs, additional, Silk, Benjamin J., additional, and Scobie, Heather M., additional

Published
2023
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38. Diabetes Mellitus, Hypertension, and Death among 32 Patients with MERS-CoV Infection, Saudi Arabia

Author

Alanazi, Khalid H., Abedi, Glen R., Midgley, Claire M., Alkhamis, Abdulrahim, Alsaqer, Taghreed, Almoaddi, Abdullah, Algwizani, Abdullah, Ghazal, Sameeh S., Assiri, Abdullah M., Jokhdar, Hani, Gerber, Susan I., Alabdely, Hail, and Watson, John T.

Subjects
Diabetes mellitus -- Risk factors -- Health aspects, Hypertension -- Risk factors -- Health aspects, Middle East respiratory syndrome -- Risk factors -- Health aspects, Kidney diseases -- Risk factors -- Health aspects, Death, Data collection, Cardiovascular diseases, Infection, Public health, Diseases, Health
Abstract

First described in 2012, infection with Middle East respiratory syndrome coronavirus (MERS-CoV) has been reported worldwide. More than 2,200 cases have been reported to the World Health Organization, and more [...]

Published
2020
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39. Protection From COVID-19 mRNA Vaccination and Prior SARS-CoV-2 Infection Against COVID-19–Associated Encounters in Adults During Delta and Omicron Predominance

Author

Bozio, Catherine H, primary, Butterfield, Kristen A, additional, Briggs Hagen, Melissa, additional, Grannis, Shaun, additional, Drawz, Paul, additional, Hartmann, Emily, additional, Ong, Toan C, additional, Fireman, Bruce, additional, Natarajan, Karthik, additional, Dascomb, Kristin, additional, Gaglani, Manjusha, additional, DeSilva, Malini B, additional, Yang, Duck-Hye, additional, Midgley, Claire M, additional, Dixon, Brian E, additional, Naleway, Allison L, additional, Grisel, Nancy, additional, Liao, I Chia, additional, Reese, Sarah E, additional, Fadel, William F, additional, Irving, Stephanie A, additional, Lewis, Ned, additional, Arndorfer, Julie, additional, Murthy, Kempapura, additional, Riddles, John, additional, Valvi, Nimish R, additional, Mamawala, Mufaddal, additional, Embi, Peter J, additional, Thompson, Mark G, additional, and Stenehjem, Edward, additional

Published
2023
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40. CASCADIA: A prospective community-based study protocol for assessing SARS-CoV-2 vaccine effectiveness in children and adults utilizing a remote nasal swab collection and web-based survey design

Author

Babu, Tara M., primary, Feldstein, Leora R., additional, Saydah, Sharon, additional, Acker, Zachary, additional, Boisvert, Cassandra L., additional, Briggs-Hagen, Melissa, additional, Carone, Marco, additional, Casto, Amanda, additional, Cox, Sarah N., additional, Ehmen, Brenna, additional, Englund, Janet A., additional, Fortmann, Stephen P., additional, Frivold, Collrane J., additional, Groom, Holly, additional, Han, Peter, additional, Kuntz, Jennifer L., additional, Lockwood, Tina, additional, Midgley, Claire M., additional, Mularski, Richard A., additional, Ogilvie, Tara, additional, Reich, Sacha, additional, Schmidt, Mark A., additional, Smith, Ning, additional, Starita, Lea, additional, Stone, Jeremy, additional, Vandermeer, Meredith, additional, Weil, Ana A., additional, Wolf, Caitlin R., additional, Chu, Helen Y., additional, and Naleway, Allison L., additional

Published
2023
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41. Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

Author

Assiri, Abdullah M., Midgley, Claire M., Abedi, Glen R., Saeed, Abdulaziz Bin, Almasri, Malak M., Lu, Xiaoyan, Al-Abdely, Hail M., Abdalla, Osman, Mohammed, Mutaz, Algarni, Homoud S., Alhakeem, Raafat F., Sakthivel, Senthilkumar K., Nooh, Randa, Alshayab, Zainab, Alessa, Mohammad, Srinivasamoorthy, Ganesh, AlQahtani, Saeed Yahya, Kheyami, Ali, HajOmar, Waleed Husein, Banaser, Talib M., Esmaeel, Ahmad, Hall, Aron J., Curns, Aaron T., Tamin, Azaibi, Alsharef, Ali Abraheem, Erdman, Dean, Watson, John T., and Gerber, Susan I.

Published
2016

42. Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation

Author

Midgley, Claire M, Watson, John T, Nix, W Allan, Curns, Aaron T, Rogers, Shannon L, Brown, Betty A, Conover, Craig, Dominguez, Samuel R, Feikin, Daniel R, Gray, Samantha, Hassan, Ferdaus, Hoferka, Stacey, Jackson, Mary Anne, Johnson, Daniel, Leshem, Eyal, Miller, Lisa, Nichols, Janell Bezdek, Nyquist, Ann-Christine, Obringer, Emily, Patel, Ajanta, Patel, Megan, Rha, Brian, Schneider, Eileen, Schuster, Jennifer E, Selvarangan, Rangaraj, Seward, Jane F, Turabelidze, George, Oberste, M Steven, Pallansch, Mark A, and Gerber, Susan I

Published
2015
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43. COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis--California and New York, May-November 2021

Author

Leon, Tomas M., Dorabawila, Vajeera, Nelson, Lauren, Lutterloh, Emily, Bauer, Ursula E., Backenson, Bryon, Bassett, Mary T., Henry, Hannah, Bregman, Brooke, Midgley, Claire M., Myers, Jennifer F., Plumb, Ian D., Reese, Heather E., Zhao, Rui, Briggs-Hagen, Melissa, Hoefer, Dina, Watt, James P., Silk, Benjamin J., Jain, Seema, and Rosenberg, Eli S.

Subjects
Johnson & Johnson, Vaccination -- Health aspects, Public health -- Health aspects, Resveratrol -- Health aspects, Pharmaceutical industry -- Health aspects, Health
Abstract

On January 19, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). By November 30, 2021, approximately 130,781 COVID-19-associated deaths, one in six of [...]

Published
2022

44. Longitudinal and quantitative fecal shedding dynamics of SARSCoV-2, pepper mild mottle virus, and crAssphage.

Author

Arts, Peter J., Kelly, J. Daniel, Midgley, Claire M., Anglin, Khamal, Lu, Scott, Abedi, Glen R., Andino, Raul, Bakker, Kevin M., Banman, Bryon, Boehm, Alexandria B., Briggs-Hagen, Melissa, Brouwer, Andrew F., Davidson, Michelle C., Eisenberg, Marisa C., Garcia-Knight, Miguel, Knight, Sterling, Peluso, Michael J., Pineda-Ramirez, Jesus, Sanchez, Ruth Diaz, and Saydah, Sharon

Published
2023
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45. Enterovirus D68-Associated Acute Respiratory Illness--New Vaccine Surveillance Network, United States, July-November 2018-2020

Author

Shah, Melisa M., Perez, Ariana, Lively, Joana Y., Avadhanula, Vasanthi, Boom, Julie A., Chappell, James, Englund, Janet A., Fregoe, Wende, Halasa, Natasha B., Harrison, Christopher J., Hickey, Robert W., Klein, Eileen J., McNeal, Monica M., Michaels, Marian G., Moffatt, Mary E., Otten, Catherine, Sahni, Leila C., Schlaudecker, Elizabeth, Schuster, Jennifer E., Selvarangan, Rangaraj, Staat, Mary A., Stewart, Laura S., Weinberg, Geoffrey A., Williams, John V., Ng, Terry Fan Fei, Routh, Janell A., Gerber, Susan I., McMorrow, Meredith L., Rha, Brian, and Midgley, Claire M.

Subjects
Respiratory tract diseases, Vaccines, Health
Abstract

Enterovirus D68 (EV-D68) is associated with a broad spectrum of illnesses, including mild to severe acute respiratory illness (ARI) and acute flaccid myelitis (AFM). Enteroviruses, including EV-D68, are typically detected [...]

Published
2021

46. Infectious viral shedding of SARS-CoV-2 Delta following vaccination: A longitudinal cohort study

Author

Garcia-Knight, Miguel, primary, Anglin, Khamal, additional, Tassetto, Michel, additional, Lu, Scott, additional, Zhang, Amethyst, additional, Goldberg, Sarah A., additional, Catching, Adam, additional, Davidson, Michelle C., additional, Shak, Joshua R., additional, Romero, Mariela, additional, Pineda-Ramirez, Jesus, additional, Diaz-Sanchez, Ruth, additional, Rugart, Paulina, additional, Donohue, Kevin, additional, Massachi, Jonathan, additional, Sans, Hannah M., additional, Djomaleu, Manuella, additional, Mathur, Sujata, additional, Servellita, Venice, additional, McIlwain, David, additional, Gaudiliere, Brice, additional, Chen, Jessica, additional, Martinez, Enrique O., additional, Tavs, Jacqueline M., additional, Bronstone, Grace, additional, Weiss, Jacob, additional, Watson, John T., additional, Briggs-Hagen, Melissa, additional, Abedi, Glen R., additional, Rutherford, George W., additional, Deeks, Steven G., additional, Chiu, Charles, additional, Saydah, Sharon, additional, Peluso, Michael J., additional, Midgley, Claire M., additional, Martin, Jeffrey N., additional, Andino, Raul, additional, and Kelly, J. Daniel, additional

Published
2022
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48. Dynamics of infection-elicited SARS-CoV-2 antibodies in children over time

Author

Gentles, Lauren E., primary, Kehoe, Leanne, additional, Crawford, Katharine H.D., additional, Lacombe, Kirsten, additional, Dickerson, Jane, additional, Wolf, Caitlin, additional, Yuan, Joanna, additional, Schuler, Susanna, additional, Watson, John T., additional, Nyanseor, Sankan, additional, Briggs-Hagen, Melissa, additional, Saydah, Sharon, additional, Midgley, Claire M., additional, Pringle, Kimberly, additional, Chu, Helen, additional, Bloom, Jesse D., additional, and Englund, Janet A., additional

Published
2022
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49. Twelve-month Follow-up of Early COVID-19 Cases in the United States: Cellular and Humoral Immune Longevity

Author

Shah, Melisa M, primary, Rasheed, Mohammad Ata Ur, additional, Harcourt, Jennifer L, additional, Abedi, Glen R, additional, Stumpf, Megan M, additional, Kirking, Hannah L, additional, Tamin, Azaibi, additional, Mills, Lisa, additional, Armstrong, Madeleine, additional, Salvatore, Phillip P, additional, Surasi, Krishna, additional, Scott, Sarah E, additional, Killerby, Marie E, additional, Briggs-Hagen, Melissa, additional, Saydah, Sharon, additional, Tate, Jacqueline E, additional, Fry, Alicia M, additional, Hall, Aron J, additional, Thornburg, Natalie J, additional, and Midgley, Claire M, additional

Published
2022
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50. Symptom Profiles of a Convenience Sample of Patients with COVID-19 — United States, January–April 2020

Author

Burke, Rachel M., Killerby, Marie E., Newton, Suzanne, Ashworth, Candace E., Berns, Abby L., Brennan, Skyler, Bressler, Jonathan M., Bye, Erica, Crawford, Richard, Harduar Morano, Laurel, Lewis, Nathaniel M., Markus, Tiffanie M., Read, Jennifer S., Rissman, Tamara, Taylor, Joanne, Tate, Jacqueline E., Midgley, Claire M., Balachandran, Neha, Dahl, Rebecca M., Dott, Mary, Gilani, Zunera, Grober, Aaron, Leung, Jessica, O’Hegarty, Michelle, Person, John, Ricaldi, Jessica N., Roth, Nicole M., Sejvar, James J., Shimabukuro, Tom, Tran, Cuc H., Watson, John T., Whitham, Hilary, Chiou, Howard, Clogher, Paula, Duca, Lindsey M., Dratch, Alissa, Feldpausch, Amanda, Fill, Mary-Margaret, Ghinai, Isaac, Holshue, Michelle, Scott, Sarah, and Westergaard, Ryan

Subjects
myalgia, Male, Pediatrics, Health (social science), Epidemiology, Health, Toxicology and Mutagenesis, 01 natural sciences, Severity of Illness Index, 0302 clinical medicine, Health Information Management, Pandemic, 030212 general & internal medicine, Full Report, Young adult, Child, Aged, 80 and over, General Medicine, Middle Aged, Hospitalization, Child, Preschool, Chills, Female, medicine.symptom, Symptom Assessment, Coronavirus Infections, Adult, medicine.medical_specialty, Adolescent, Fever, Pneumonia, Viral, MEDLINE, 03 medical and health sciences, Betacoronavirus, Young Adult, Severity of illness, medicine, Humans, 0101 mathematics, Pandemics, Aged, business.industry, SARS-CoV-2, Public health, 010102 general mathematics, COVID-19, Infant, medicine.disease, United States, Pneumonia, Dyspnea, Cough, business
Abstract

Coronavirus disease 2019 (COVID-19) was first detected in the United States in January 2020 (1), and by mid-July, approximately 3.4 million cases had been reported in the United States (2). Information about symptoms among U.S. COVID-19 patients is limited, especially among nonhospitalized patients. To better understand symptom profiles of patients with laboratory-confirmed COVID-19 in the United States, CDC used an optional questionnaire to collect detailed information on a convenience sample of COVID-19 patients from participating states. Symptom data were analyzed by age group, sex, hospitalization status, and symptom onset date relative to expansion of testing guidelines on March 8, 2020 (3). Among 164 symptomatic patients with known onset during January 14-April 4, 2020, a total of 158 (96%) reported fever, cough, or shortness of breath. Among 57 hospitalized adult patients (aged ≥18 years), 39 (68%) reported all three of these symptoms, compared with 25 (31%) of the 81 nonhospitalized adult patients. Gastrointestinal (GI) symptoms and other symptoms, such as chills, myalgia, headache, and fatigue, also were commonly reported, especially after expansion of testing guidelines. To aid prompt recognition of COVID-19, clinicians and public health professionals should be aware that COVID-19 can cause a wide variety of symptoms.

Published
2020

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