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Your search keyword '"Middelkoop, Huub A.M."' showing total 29 results
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29 results on '"Middelkoop, Huub A.M."'

1. Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy

Author

Kaushik, Kanishk, de Kort, Anna M., van Dort, Rosemarie, van der Zwet, Reinier G.J., Siegerink, Bob, Voigt, Sabine, van Zwet, Erik W., van der Plas, Maaike C., Koemans, Emma A., Rasing, Ingeborg, Kessels, Roy P.C., Middelkoop, Huub A.M., Schreuder, Floris H.B.M., Klijn, Catharina J.M., Verbeek, Marcel M., Terwindt, Gisela M., van Etten, Ellis S., and Wermer, Marieke J.H.

Published
2024
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3. Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer’s disease

Author

Bron, Esther E., Klein, Stefan, Papma, Janne M., Jiskoot, Lize C., Venkatraghavan, Vikram, Linders, Jara, Aalten, Pauline, De Deyn, Peter Paul, Biessels, Geert Jan, Claassen, Jurgen A.H.R., Middelkoop, Huub A.M., Smits, Marion, Niessen, Wiro J., van Swieten, John C., van der Flier, Wiesje M., Ramakers, Inez H.G.B., and van der Lugt, Aad

Published
2021
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6. Cognitive functioning as a predictor of employment status in relapsing-remitting multiple sclerosis: a 2-year longitudinal study

Author

van Gorp, Dennis A.M., van der Hiele, Karin, Heerings, Marco A.P., Jongen, Peter J., van der Klink, Jac J.L., Reneman, Michiel F., Arnoldus, Edo P.J., Beenakker, Ernesto A.C., van Eijk, Jeroen J.J., Frequin, Stephan T.F.M., de Gans, Koen, Hoitsma, Elske, Mostert, Jop P., Verhagen, Wim I.M., Zemel, Désirée, Visser, Leo H., and Middelkoop, Huub A.M.

Published
2019
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7. Predicting Motor Outcome and Quality of Life After Subthalamic Deep Brain Stimulation for Parkinson’s Disease: The Role of Standard Screening Measures and Wearable-Data

Author

Geraedts, Victor J., primary, van Vugt, Jeroen P.P., additional, Marinus, Johan, additional, Kuiper, Roy, additional, Middelkoop, Huub A.M., additional, Zutt, Rodi, additional, van der Gaag, Niels A., additional, Hoffmann, Carel F.E., additional, Dorresteijn, Lucille D.A., additional, van Hilten, Jacobus J., additional, and Contarino, Maria Fiorella, additional

Published
2023
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11. Preoperative Electroencephalography‐Based Machine Learning Predicts Cognitive Deterioration After Subthalamic Deep Brain Stimulation

Author

Geraedts, Victor J., primary, Koch, Milan, additional, Kuiper, Roy, additional, Kefalas, Marios, additional, Bäck, Thomas H.W., additional, van Hilten, Jacobus J., additional, Wang, Hao, additional, Middelkoop, Huub A.M., additional, van der Gaag, Niels A., additional, Contarino, Maria Fiorella, additional, and Tannemaat, Martijn R., additional

Published
2021
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13. Eighteen-Year Disease Progression and Survival in CADASIL

Author

Gravesteijn, Gido, primary, Hack, Remco J., additional, Opstal, Anna M. van, additional, van Eijsden, Bastian J., additional, Middelkoop, Huub A.M., additional, Rodriguez Girondo, Mar D.M., additional, Aartsma-Rus, Annemieke, additional, Grond, Jeroen van de, additional, Rutten, Julie W., additional, and Oberstein, Saskia A.J. Lesnik, additional

Published
2021
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17. Cortical phase changes measured using 7-T MRI in subjects with subjective cognitive impairment, and their association with cognitive function

Author

van Rooden, Sanneke, Buijs, Mathijs, van Vliet, Marjolein E., Versluis, Maarten J., Webb, Andrew G., Oleksik, Ania M., van de Wiel, Lotte, Middelkoop, Huub A.M., Blauw, Gerard Jan, Weverling-Rynsburger, Annelies W.E., Goos, Jeroen D.C., van der Flier, Wiesje M., Koene, Ted, Scheltens, Philip, Barkhof, Frederik, Nieuwerth-van de Rest, Ondine, Slagboom, P.E., van Buchem, Mark A., van der Grond, Jeroen, Neurology, Epidemiology and Data Science, Radiology and nuclear medicine, and Amsterdam Neuroscience - Brain Imaging

Subjects
Global Nutrition, cognition, Wereldvoeding, brain imaging, Alzheimer's disease, phase, AD pathology, human 7-T MRI, subjective cognitive impairment, VLAG
Abstract

Studies have suggested that, in subjects with subjective cognitive impairment (SCI), Alzheimer's disease (AD)‐like changes may occur in the brain. Recently, an in vivo study has indicated the potential of ultra‐high‐field MRI to visualize amyloid‐beta (Aβ)‐associated changes in the cortex in patients with AD, manifested by a phase shift on T2*‐weighted MRI scans. The main aim of this study was to investigate whether cortical phase shifts on T2*‐weighted images at 7 T in subjects with SCI can be detected, possibly implicating the deposition of Aβ plaques and associated iron. Cognitive tests and T2*‐weighted scans using a 7‐T MRI system were performed in 28 patients with AD, 18 subjects with SCI and 27 healthy controls (HCs). Cortical phase shifts were measured. Univariate general linear modeling and linear regression analysis were used to assess the association between diagnosis and cortical phase shift, and between cortical phase shift and the different neuropsychological tests, adjusted for age and gender. The phase shift (mean, 1.19; range, 1.00–1.35) of the entire cortex in AD was higher than in both SCI (mean, 0.85; range, 0.73–0.99; p

Published
2016
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19. Advanced magnetic resonance imaging of the brain in patients treated with TNF-alpha blocking agents

Author

van der Bijl, Arie E., Emmer, Bart J., Breedveld, Ferdinand C., Middelkoop, Huub A.M., Jurgens, Carolien K., van Buchem, Marc A., Huizinga, Tom W.J., van der Grond, Jeroen, Radiology and Nuclear Medicine, and ANS - Neurovascular Disorders

Subjects
Anti-TFN, Brain, MRI
Abstract

Objective. Neurological symptoms have been reported in patients treated with anti-TNF-alpha. In a pilot study we evaluated the effect of anti-TNF-alpha on cerebral parenchyma using advanced Magnetic Resonance (MR) techniques. Methods. Seven patients with a systemic inflammatory disease (5 rheumatoid arthritis, 2 psoriatic arthritis) had Magnetization Transfer Imaging, Diffusion Weighted Imaging (DWI) and Magnetic Resonance Spectroscopy (MRS) of the brain before and after administration of anti-TNF-alpha. Four patients were neuropsychologically evaluated. Results. After treatment with TNF-alpha blocking agents the Magnetization Transfer Ratio histogram Peak-heights (MTR-Pht) of the white and gray matter decreased (p < 0.01 and p < 0.05 respectively). The Apparent Diffusion Coefficient for the white and gray matter and the metabolite ratios in the centrum semiovale did not significantly change after therapy. Neuropsychological assessment showed no difference before and after anti-TNF-alpha. Conclusions. The decrease of the MTR-Pht after anti-TNF-alpha therapy suggests loss of parenchyma integrity; however, these changes could not be attributed to inflammation or demyelination based on our complementary DWI and MRS data. The decrease of the MTR-Pht did not result in decreased cognitive function.

Published
2007

23. Cerebral atrophy in elderly with subjective memory complaints

Author

Palm, Walter M., primary, Ferrarini, Luca, additional, van der Flier, Wiesje M., additional, Westendorp, Rudi G.J., additional, Bollen, Eduard L.E.M., additional, Middelkoop, Huub A.M., additional, Milles, Julien R., additional, van der Grond, Jeroen, additional, and van Buchem, Mark A., additional

Published
2012
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24. Prospective Study of Clinical Phenotypes in Neuropsychiatric Systemic Lupus Erythematosus; Multidisciplinary Approach to Diagnosis and Therapy

Author

ZIRKZEE, ELISABETH J.M., primary, STEUP-BEEKMAN, GERDA M., additional, van der MAST, ROOS C., additional, BOLLEN, EDUARD L.E.M., additional, van der WEE, NIC J.A., additional, BAPTIST, ESTHER, additional, SLEE, THOMAS M., additional, HUISMAN, MENNO V., additional, MIDDELKOOP, HUUB A.M., additional, LUYENDIJK, JASPER, additional, van BUCHEM, MARK A., additional, and HUIZINGA, TOM W.J., additional

Published
2012
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25. Shape Abnormalities of the Striatum in Alzheimer's Disease

Author

de Jong, Laura W., primary, Ferrarini, Luca, additional, van der Grond, Jeroen, additional, Milles, Julien R., additional, Reiber, Johan H.C., additional, Westendorp, Rudi G.J., additional, Bollen, Edward L.E.M., additional, Middelkoop, Huub A.M., additional, and van Buchem, Mark A., additional

Published
2011
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