1. Mixed Quantum-Classical Methods for Molecular Simulations of Biochemical Reactions With Microwave Fields: The Case Study of Myoglobin.
- Author
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Apollonio, Francesca, Liberti, Micaela, Amadei, Andrea, Aschi, Massimiliano, Pellegrino, Monica, D'Alessandro, Maira, D'Abramo, Marco, Di Nola, Alfredo, and d'Inzeo, Guglielmo
- Subjects
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MYOGLOBIN , *BIOCHEMISTRY , *MICROWAVES , *QUANTUM theory , *LIGANDS (Biochemistry) , *BIOREACTORS - Abstract
Contradictory data in the huge literature on microwaves bio-effects may result from a poor understanding of the mechanisms of interaction between microwaves and biological systems. Molecular simulations of biochemical processes seem to be a promising tool to comprehend microwave induced bio-effects. Molecular simulations of classical and quantum events involved in relevant biochemical processes enable to follow the dynamic evolution of a biochemical reaction in the presence of microwave fields. In this paper, the action of a microwave signal (1 GHz) on the covalent binding process of a ligand (carbon monoxide) to a protein (myoglobin) has been studied. Our results indicate that microwave fields, with intensities much below the atomic/molecular electric interactions, cannot affect such biochemical process. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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