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257 results on '"Mickelson, J. R."'

2. Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse

Author

Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, Wade, C. M., Giulotto, E., Sigurdsson, S., Zoli, M., Gnerre, S., Imsland, F., Lear, T. L., Adelson, D. L., Bailey, E., Bellone, R. R., Blöcker, H., Distl, O., Edgar, R. C., Garber, M., Leeb, T., Mauceli, E., MacLeod, J. N., Penedo, M. C. T., Raison, J. M., Sharpe, T., Vogel, J., Andersson, L., Antczak, D. F., Biagi, T., Binns, M. M., Chowdhary, B. P., Coleman, S. J., Valle, G. Delia, Fryc, S., Guérin, G., Hasegawa, T., Hill, E. W., Jurka, J., Kiialainen, A., Lindgren, G., Liu, J., Magnani, E., Mickelson, J. R., Murray, J., Nergadze, S. G., Onofrio, R., Pedroni, S., Piras, M. F., Raudsepp, T., Rocchi, M., Røed, K. H., Ryder, O. A., Searle, S., Skow, L., Swinburne, J. E., Syvänen, A. C., Tozaki, T., Valberg, S. J., Vaudin, M., White, J. R., Zody, M. C., Lander, E. S., and Lindblad-Toh, K.

Published
2009
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12. Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse

Author

Wade, C. M., Giulotto, E., Sigurdsson, S., Zoti, M., Gnerre, S., Imsland, F., Lear, T. L., Adelson, D. L., Bailey, E., Bellone, R. R., Blocker, H., Distl, O., Edgar, R. C., Garber, M., Leeb, T., Mauceli, E., MacLeod, J. N., T. Penedo, M. C., Raison, J. M., Sharpe, T., Vogel, J., Andersson, L., Antczak, D. F., Biagi, T., Binns, M. M., Chowdhary, B. P., Coleman, S. J., Valle, Delia G., Fryc, S., Guérin, G., Hasegawa, T., Hill, E. W., Jurka, J., Kiialainen, A., Lindgren, G., Liu, J., Magnani, E., Mickelson, J. R., Murray, J., Nergadze, S. G., Onofrio, R., Pedroni, S., Piras, M. F., Raudsepp, T., Rocchi, M., Reed, K. H., Ryder, O. A., Searle, S., Skow, L., Swinburne, J. E., Syvanen, A. C., Tozaki, T., Valberg, S. J., Vaudin, M., White, J. R., Zody, M. C., Lander, E. S., and Lindblad-Toh, K.

Published
2009

14. Identification and validation of genetic variants predictive of gait in standardbred horses

Author

McCoy, A M, Beeson, S K, Rubin, C-J, Andersson, L, Caputo, P, Lykkjen, S, Moore, A, Piercy, R J, Mickelson, J R, and McCue, M E

Abstract

Several horse breeds have been specifically selected for the ability to exhibit alternative patterns of locomotion, or gaits. A premature stop codon in the gene DMRT3 is permissive for “gaitedness” across breeds. However, this mutation is nearly fixed in both American Standardbred trotters and pacers, which perform a diagonal and lateral gait, respectively, during harness racing. This suggests that modifying alleles must influence the preferred gait at racing speeds in these populations. A genome-wide association analysis for the ability to pace was performed in 542 Standardbred horses (n = 176 pacers, n = 366 trotters) with genotype data imputed to ~74,000 single nucleotide polymorphisms (SNPs). Nineteen SNPs on nine chromosomes (ECA1, 2, 6, 9, 17, 19, 23, 25, 31) reached genome-wide significance (p < 1.44 x 10−6). Variant discovery in regions of interest was carried out via whole-genome sequencing. A set of 303 variants from 22 chromosomes with putative modifying effects on gait was genotyped in 659 Standardbreds (n = 231 pacers, n = 428 trotters) using a high-throughput assay. Random forest classification analysis resulted in an out-of-box error rate of 0.61%. A conditional inference tree algorithm containing seven SNPs predicted status as a pacer or trotter with 99.1% accuracy and subsequently performed with 99.4% accuracy in an independently sampled population of 166 Standardbreds (n = 83 pacers, n = 83 trotters). This highly accurate algorithm could be used by owners/trainers to identify Standardbred horses with the potential to race as pacers or as trotters, according to the genotype identified, prior to initiating training and would enable fine-tuning of breeding programs with designed matings. Additional work is needed to determine both the algorithm’s utility in other gaited breeds and whether any of the predictive SNPs play a physiologically functional role in the tendency to pace or tag true functional alleles.

Published
2019

24. Report of the International Equine Gene Mapping Workshop: male linkage map

Author

Guérin, G, Bailey, E, Bernoco, D, Anderson, I, Antczak, D F, Bell, K, Binns, M M, Bowling, A T, Brandon, R, Cholewinski, G, Cothran, E G, Ellegren, H, Förster, M, Godard, S, Horin, P, Ketchum, M, Lindgren, G, McPartlan, H, Mériaux, J -C, Mickelson, J R, Millon, L V, Murray, J, Neau, A, Røed, K, Sandberg, K, Shiue, Y-L, Skow, L C, Stott, M, Swinburne, J, Valberg, S J, Van Haeringen, H, Van Haeringen, W A, and Ziegle, J

Published
1999

30. Canine NAPEPLD-associated models of human myelin disorders

Author

Minor, K. M., primary, Letko, A., additional, Becker, D., additional, Drögemüller, M., additional, Mandigers, P. J. J., additional, Bellekom, S. R., additional, Leegwater, P. A. J., additional, Stassen, Q. E. M., additional, Putschbach, K., additional, Fischer, A., additional, Flegel, T., additional, Matiasek, K., additional, Ekenstedt, K. J., additional, Furrow, E., additional, Patterson, E. E., additional, Platt, S. R., additional, Kelly, P. A., additional, Cassidy, J. P., additional, Shelton, G. D., additional, Lucot, K., additional, Bannasch, D. L., additional, Martineau, H., additional, Muir, C. F., additional, Priestnall, S. L., additional, Henke, D., additional, Oevermann, A., additional, Jagannathan, V., additional, Mickelson, J. R., additional, and Drögemüller, C., additional

Published
2018
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31. Heritability of metabolic traits associated with equine metabolic syndrome in Welsh ponies and Morgan horses.

Author

Norton, E. M., Schultz, N. E., Rendahl, A. K., Mcfarlane, D., Geor, R. J., Mickelson, J. R., and McCue, M. E.

Abstract

Summary: Background: Equine metabolic syndrome (EMS) is a complex clinical disorder with both environmental and genetic factors contributing to EMS phenotypes. Estimates of heritability determine the proportion of variation in a trait that is attributable to genetics. Objectives: To provide heritability estimates for nine metabolic traits associated with EMS in two high‐risk breeds. Study design: Retrospective cohort study. Methods: High‐density single‐nucleotide polymorphism (SNP) genotype data was used to estimate the heritability (h2SNP) of nine metabolic traits relevant to EMS in a cohort of 264 Welsh ponies and 286 Morgan horses. Traits included measurements of insulin, glucose, non‐esterified fatty acids (NEFA), triglycerides, leptin, adiponectin, ACTH, and glucose (GLU‐OST) and insulin (INS‐OST) following an oral sugar challenge. Results: In Welsh ponies, seven of the nine traits had statistically significant h2SNP estimates that were considered moderately to highly heritable (h2SNP>0.20) including: triglycerides (0.313; s.e. = 0.146), glucose (0.408; s.e. = 0.135), NEFA (0.434; s.e. = 0.136), INS‐OST (0.440; s.e. = 0.148), adiponectin (0.488; s.e. = 0.143), leptin (0.554; s.e. = 0.132) and insulin (0.808; s.e. = 0.108). In Morgans, six of the nine traits had statistically significant h2SNP estimates that were also determined to be moderately to highly heritable including: INS‐OST (0.359; s.e. = 0.185), leptin (0.486; s.e. = 0.177), GLU‐OST (0.566 s.e. = 0.175), insulin (0.592; s.e. = 0.195), NEFA (0.684; s.e. = 0.164), and adiponectin (0.913; s.e. = 0.181). Main limitations: Insufficient population size may have limited power to obtain statistically significant h2SNP estimates for ACTH (both breeds), glucose and triglycerides in Morgans and GLU‐OST in Welsh ponies. Conclusions: This study provides the first concrete evidence of a genetic contribution to key phenotypes associated with EMS. Eight of these nine traits had moderate to high h2SNP estimates in this cohort. These data demonstrate that continued research for identification of the genetic risk factors for EMS phenotypes within and across breeds is warranted. [ABSTRACT FROM AUTHOR]

Published
2019
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32. SNP‐based heritability and genetic architecture of tarsal osteochondrosis in North American Standardbred horses.

Author

McCoy, A. M., Norton, E. M., Kemper, A. M., Beeson, S. K., Mickelson, J. R., and McCue, M. E.

Subjects
OSTEOCHONDROSIS, HORSE diseases, HERITABILITY, GENETIC polymorphisms, SINGLE nucleotide polymorphisms
Abstract

Summary: Osteochondrosis is a common developmental orthopedic disease characterized by a failure of endochondral ossification. Standardbred horses are recognized as being predisposed to tarsal osteochondrosis. Prior heritability estimates for tarsal osteochondrosis in European Standardbreds and related trotting breeds have been based on pedigree data and range from 17–29%. Here, we report on genetic architecture and heritability based on high‐density genotyping data in a cohort of North American Standardbreds (n = 479) stringently phenotyped for tarsal osteochondrosis. Whole‐genome array genotyping data were imputed to ~2 million single nucleotide polymorphisms (SNPs). SNP‐based heritability of osteochondrosis in this population was explained by 2326 SNPs. The majority of these SNPs (86.6%) had small effects, whereas fewer SNPs had moderate or large effects (10% and 2.9% respectively), which is consistent with a polygenic/complex disease. Heritability was estimated at 0.24 ± 0.16 using two methods of restricted maximum likelihood analysis, as implemented in gcta (with and without a weighted relatedness matrix) and ldak software. Estimates were validated using bootstrapping. Heritability estimates were within the range previously reported and suggest that osteochondrosis is moderately heritable but that a significant portion of disease risk is due to environmental factors and/or genotype × environment interactions. Future identification of the genes/variants that have the most impact on disease risk may allow early recognition of high‐risk individuals. [ABSTRACT FROM AUTHOR]

Published
2019
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34. Identification of Ancestry Informative Markers in the Domestic Horse

Author

Petersen, J. L., Mickelson, J. R., Andersson, L. S., Bailey, E., Bannasch, D. L., Binns, M. M., Borges, A. S., Cothran, E. G., Câmara Machado, A., Distl, O., Felicetti, Michela, Graves, K. T., Guérin, G., Hasegawa, T., Haase, B., Hill, E. W., Leeb, T., Lopes, M. S., Lindgren, G., Lohi, H., Penedo, M. C. T., Piercy, R., Røed, K. H., Ryder, O. A., Silvestrelli, Maurizio, Swinburne, J. E., Tozaki, T., Vaudin, M., Wade, C. M., and Mccue, M. E.

Published
2012

35. The Equine Genetic Diversity Consortium: an international collaboration to describe genetic variation in modern horse breeds

Author

Petersen, J. L., Mickelson, J. R., Andersson, L. S., Bailey, E., Bannasch, D. L., Binns, M. M., Borges, A. S., Cothran, E. G., Câmara Machado, A., Distl, O., Felicetti, Michela, Graves, K. T., Guérin, G., Hasegawa, T., Haase, B., Hill, E. W., Leeb, T., Lopes, M. S., Lindgren, G., Lohi, H., Penedo, M. C. T., Piercy, R., Røed, K. H., Ryder, O. A., Silvestrelli, Maurizio, Swinburne, J. E., Tozaki, T., Vaudin, M., Wade, C. M., and Mccue, M. E.

Published
2011

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