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134 results on '"Michowiz, Shalom"'

4. Ruptured Cerebellar Micro-AVM Presenting with Lobar (Semilunar Lobe) Hemorrhage Causing Deep Coma: Surgical Evacuation of the Hemorrhage Followed by Embolization Utilizing a Wedged Flow-Directed Microcatheter and Concentrated nBCA Mixture; Main Feeder, Nidus, and Draining Vein Occlusion Leading to Cure and Excellent Clinical Evolution

Author

Cohen, José E., primary, Elor, Guy, additional, Michowiz, Shalom, additional, Maotasim, Schweiky, additional, and Rajz, Gustavo, additional

Published
2021
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11. Characterization of Diabetic Retinopathy in Two Mouse Models and Response to a Single Injection of Anti-Vascular Endothelial Growth Factor.

Author

Azrad-Leibovich, Tamar, Zahavi, Alon, Gohas, Moran Friedman, Brookman, Myles, Barinfeld, Orit, Muhsinoglu, Orkun, Michowiz, Shalom, Fixler, Dror, and Goldenberg-Cohen, Nitza

Subjects
ENDOTHELIAL growth factors, BEVACIZUMAB, DIABETIC retinopathy, LABORATORY mice, TYPE 1 diabetes, TYPE 2 diabetes
Abstract

In this study, we characterized diabetic retinopathy in two mouse models and the response to anti-vascular endothelial growth factor (VEGF) injection. The study was conducted in 58 transgenic, non-obese diabetic (NOD) mice with spontaneous type 1 diabetes (n = 30, DMT1-NOD) or chemically induced (n = 28, streptozotocin, STZ-NOD) type 1 diabetes and 20 transgenic db/db mice with type 2 diabetes (DMT2-db/db); 30 NOD and 8 wild-type mice served as controls. Mice were examined at 21 days for vasculopathy, retinal thickness, and expression of genes involved in oxidative stress, angiogenesis, gliosis, and diabetes. The right eye was histologically examined one week after injection of bevacizumab, ranibizumab, saline, or no treatment. Flat mounts revealed microaneurysms and one apparent area of tufts of neovascularization in the diabetic retina. Immunostaining revealed activation of Müller glia and prominent Müller cells. Mean retinal thickness was greater in diabetic mice. RAGE increased and GFAP decreased in DMT1-NOD mice; GFAP and SOX-9 mildly increased in db/db mice. Anti-VEGF treatment led to reduced retinal thickness. Retinas showed vasculopathy and edema in DMT1-NOD and DMT2-db/db mice and activation of Müller glia in DMT1-NOD mice, with some response to anti-VEGF treatment. Given the similarity of diabetic retinopathy in mice and humans, comparisons of type 1 and type 2 diabetic mouse models may assist in the development of new treatment modalities. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Diffuse Leptomeningeal Glioneuronal Tumor: Case Report and Review of Literature

Author

Michowiz Shalom, Ben-Shalom Netanel, Rajz Gustavo, Marglit Nevo, Marianayagam Neelan J, and Toledano Helen

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Pathology Report, medicine.disease, Hydrocephalus, Cns malignancy, Glioneuronal tumor, Rare case, Biopsy, medicine, Vomiting, Radiology, medicine.symptom, Papilledema, business
Abstract

In this study, we describe a rare case of disseminated CNS malignancy of childhood. A seven-year-old boy with headache, vomiting and gait disturbances was diagnosed with non-obstructive hydrocephalus and papilledema. Initial MRI revealed no significant findings, however subsequent studies revealed bilateral extradural and leptomeningeal enhancement. Biopsy was eventually obtained with pathology report confirming leptomeningeal oligodendrogliomatosis. We discuss the recent description in literature of this rarely reported diagnosis. This entity primarily affects pediatric patients. It has a unique clincopathological identity, which can be easily mistaken for an inflammatory process. The diagnosis of this tumor can be complicated due to the rather nonspecific clinical presentation and findings on imaging.

Published
2020
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17. The need to look for deficit after stroke in children

Author

Luckman, Judith, Chokron, Sylvie, Michowiz, Shalom, Belenky, Eugenia, Toledano, Helen, Zahavi, Alon, Goldenberg-Cohen, Nitza, Fondation Ophtalmologique Adolphe de Rothschild [Paris], Centre Neurosciences intégratives et Cognition (INCC - UMR 8002), and Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

Subjects
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, eye exam, children, arterial stroke, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, ophthalmological complication
Abstract

International audience; PURPOSE: To evaluate the role of the ophthalmologist at presentation and during follow-up of children with arterial stroke.METHODS: This retrospective case series comprised 26 children with arterial stroke who were followed for at least 12 months in our tertiary pediatric medical center in 2005-2015. Demographic data and findings on radiological neuroimaging, ophthalmological and neurological examination were retrieved from the patient medical files.RESULTS: Of the 26 children identified with stroke, 5 (20%) had a metabolic syndrome, 3 (11%) cardiac anomaly, 3 (11%) recent major surgery for repair of cardiac anomaly, 3 (11%) vascular anomaly, 3 (11%), head trauma with traumatic dissection, 1 (4%) had hypercoagulability and in 8 patients (31%), no apparent cause was found (idiopathic). Only 9 (35%) had an eye exam during the follow-up. Eleven patients had a nonophthalmological neurological deficit as a result of the stroke. Positive ophthalmological manifestations included hemianopic visual field defect in 2 patients (8%), complete blindness and visual acuity deficit in one patient each (4%). At the last visit, no change in visual function was detected in those with ophthalmological deficit and 5 (20%) of the patients with other neurologic manifestations still had residual neurological deficit. CONCLUSION: Arterial stroke in children is a rare event and only a few are referred for an eye examination. In view of the significant ophthalmological manifestations revealed in the current study, children with arterial stroke should be referred for early ophthalmological evaluation.

Published
2020
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20. Task Switching After Cerebellar Damage

Author

Berger, Andrea, Sadeh, Michelle, Tzur, Gabriel, Shuper, Avinoam, Kornreich, Liora, Inbar, Dov, Cohen, Ian J., Michowiz, Shalom, Yaniv, Isaac, Constantini, Shlomi, Kessler, Yoav, and Meiran, Nachshon

Published
2005

28. EPEN-25. KANSL1 GAIN AND FUSION - A NOVEL ALTERATION IN CHILDHOOD EPENDYMOMA

Author

Margolin-Miller, Yulia, primary, Toledano, Helen, additional, Sela-Tzuriano, Lital, additional, Hameiri-Grossman, Michal, additional, Michowiz, Shalom, additional, Fichman-Horn, Suzanna, additional, Feinmesser, Meora, additional, Pfister, Stefan, additional, Witt, Hendrik, additional, Yaniv, Isaac, additional, and Avigad, Smadar, additional

Published
2018
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31. Fluorescence Lifetime Imaging Microscopy, a Novel Diagnostic Tool for Metastatic Cell Detection in the Cerebrospinal Fluid of Children with Medulloblastoma

Author

Gershanov, Sivan, primary, Michowiz, Shalom, additional, Toledano, Helen, additional, Yahav, Gilad, additional, Barinfeld, Orit, additional, Hirshberg, Avraham, additional, Ben-Zvi, Haim, additional, Mircus, Gabriel, additional, Salmon-Divon, Mali, additional, Fixler, Dror, additional, and Goldenberg-Cohen, Nitza, additional

Published
2017
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38. Long-term follow-up of benign positional vertical opsoclonus in infants: retrospective cohort.

Author

Sternfeld, Amir, Lobel, Daniella, Leiba, Hana, Luckman, Judith, Michowiz, Shalom, and Goldenberg-Cohen, Nitza

Abstract

Background/Aims Benign positional vertical opsoclonus in infants, also described as paroxysmal tonic downgaze, is an unsettling phenomenon that leads to extensive work-up, although benign course has been reported in sporadic cases. We describe long-term follow- up of a series of infants with the phenomenon. Methods This retrospective cohort included all infants diagnosed with rapid downgaze eye movement in 2012-2015 and followed until 2016. The databases of two medical centres were retrospectively reviewed. Benign positional vertical opsoclonus was diagnosed based on clinical findings of experienced neuro- ophthalmologists. Data were collected on demographics, symptoms and signs, neuro-ophthalmological and neurological evaluations, and outcome. Imaging studies were reviewed. Main outcome measures were long-term outcome and findings of the thorough investigation. results The cohort included six infants. All infants were born at term. Age at presentation was several days to 12 weeks. Episodes lasted a few seconds and varied in frequency from <10 to dozens per day. In five infants, symptoms occurred in the supine position. There was a wide variability in the work-up without any pathological findings. Follow-up ranged from 1 to 2.5 years. Ocular symptoms gradually decreased until resolution. Infants reached normal developmental milestones. Conclusions Our identification of six patients in only 3 years suggests benign positional vertical opsoclonus may be more prevalent than previously described. In our experience, it affects otherwise healthy infants and resolves spontaneously. In view of the good long-term outcome, a comprehensive clinical investigation may not be necessary. [ABSTRACT FROM AUTHOR]

Published
2018
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42. MicroRNA-mRNA expression profiles associated with medulloblastoma subgroup 4.

Author

Gershanov, Sivan, Toledano, Helen, Michowiz, Shalom, Barinfeld, Orit, Pinhasov, Albert, Goldenberg-Cohen, Nitza, and Salmon-Divon, Mali

Subjects
GENE expression, MEDULLOBLASTOMA, TUMORS in children, BIOMARKERS, RNA sequencing
Abstract

Purpose: Medulloblastoma (MB), the most common malignant brain tumor in children, is divided into four tumor subgroups: wingless-type (WNT), sonic hedgehog (SHH), Group 3, and Group 4. Ideally, clinical practice and treatment design should be subgroup specific. While WNT and SHH subgroups have well-defined biomarkers, distinguishing Group 3 from Group 4 is not straightforward. MicroRNAs (miRNAs), which regulate posttranscriptional gene expression, are involved in MB tumorigenesis. However, the miRNA-messenger RNA (mRNA) regulatory network in MB is far from being fully understood. Our aims were to investigate miRNA expression regulation in MB subgroups, to assess miRNA target relationships, and to identify miRNAs that can distinguish Group 3 from Group 4. Patients and methods: With these aims, integrated transcriptome mRNA and miRNA expression analysis was performed on primary tumor samples collected from 18 children with MB, using miRNA sequencing (miRNA-seq), RNA sequencing (RNA-seq), and quantitative PCR. Results: Of all the expressed miRNAs, 19 appeared to be significantly differentially expressed (DE) between Group 4 and non-Group 4 subgroups (false discovery rate [FDR] <0.05), including 10 miRNAs, which, for the first time, are reported to be in conjunction with MB. RNA-seq analysis identified 165 genes that were DE between Group 4 and the other subgroups (FDR <0.05), among which seven are predicted targets of five DE miRNAs and exhibit inverse expression pattern. Conclusion: This study identified miRNA molecules that may be involved in Group 4 etiology, in general, and can distinguish between Group 3 and Group 4, in particular. In addition, understanding the involvement of miRNAs and their targets in MB may improve diagnosis and advance the development of targeted treatment for MB. [ABSTRACT FROM AUTHOR]

Published
2018
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47. Relative neuroprotective effects hyperbaric oxygen treatment and TLR4 knockout in a mouse model of temporary middle cerebral artery occlusion.

Author

Pushkov, Dennis, Nicholson, James D., Michowiz, Shalom, Novitzky, Ivan, Weiss, Shirel, Ben Hemou, Moshe, Hochhauser, Edith, and Goldenberg-Cohen, Nitza

Subjects
CEREBRAL arterial diseases, NEUROPROTECTIVE agents, HYPERBARIC oxygenation, TOLL-like receptors, LABORATORY mice, THERAPEUTICS
Abstract

Purpose:To examine the effects of hyperbaric oxygen (HBO) therapy and knockout of toll-like receptor 4 (TLR4) on the outcome of temporary middle cerebral artery occlusion (MCAO) in a mouse model.Materials and Methods:MCAO was induced in anesthetized male C57Bl/6 mice (WT) and TLR4 knockout mice (TLR4−/−) using an intra-arterial filament method. After 30 or 90 min, the filament was removed, and the mice were given either no treatment (WT and TLR4−/-groups) or HBO (WT only). Mice were euthanized 24 h after MCAO, and the brain infarct area was examined using 2,3,5-triphenyltetrazolium chloride (TTC) staining.Results:In the WT group, without treatment, lesion volume was 120 ± 13 mm3in the mice subjected to 30 min’ MCAO and 173 ± 23 mm3in the mice subjected to 90 min’ MCAO. Respective values with HBO treatment were 66.5 ± 36.7 mm3and 53.2 ± 17.2 mm3. The difference was significant only for 90-minute MCAO (p< 0.01, nonparametric test). In the TLR4−/−group (all untreated), lesion volume was 95.9 ± 17.9 after 90 min of MCAO, which was significantly lower than in the untreated WT animals (p< 0.05, nonparametric test).Conclusions:A single treatment of HBO immediately after MCAO followed by 24 h’ reperfusion significantly reduces edema and may improve perfusion. TLR4 knockout protects mice from MCAO damage, but to a lesser extent than HBO treatment. [ABSTRACT FROM PUBLISHER]

Published
2016
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50. Ammonium Trichloro(dioxoethylene-o,o′)tellurate (AS101) Sensitizes Tumors to Chemotherapy by Inhibiting the Tumor Interleukin 10 Autocrine Loop

Author

Sredni, Benjamin, primary, Weil, Merav, additional, Khomenok, Gennadi, additional, Lebenthal, Ilana, additional, Teitz, Seagal, additional, Mardor, Yael, additional, Ram, Zvi, additional, Orenstein, Arie, additional, Kershenovich, Amir, additional, Michowiz, Shalom, additional, Cohen, Yan I., additional, Rappaport, Zvi H., additional, Freidkin, Ilya, additional, Albeck, Michael, additional, Longo, Dan L., additional, and Kalechman, Yona, additional

Published
2004
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