76 results on '"Michi, Y."'
Search Results
2. Pharmacist-led multi-faceted intervention in an antimicrobial stewardship programme at a dental university hospital in Japan
- Author
-
Okihata, R., primary, Michi, Y., additional, Sunakawa, M., additional, and Tagashira, Y., additional
- Published
- 2023
- Full Text
- View/download PDF
3. First signs of late-presenting cervical lymph node metastasis in oral cancers during follow-up
- Author
-
Sumino, J., Uzawa, N., Ohyama, Y., Michi, Y., Kawamata, A., Mizutani, M., and Yamashiro, M.
- Published
- 2017
- Full Text
- View/download PDF
4. Analysis of the factors affecting the formation of the microbiome associated with chronic osteomyelitis of the jaw
- Author
-
Goda, A., Maruyama, F., Michi, Y., Nakagawa, I., and Harada, K.
- Published
- 2014
- Full Text
- View/download PDF
5. Epithelial-Myoepithelial Carcinoma of The Minor Salivary Glands: Report of Two Cases with Literature Review
- Author
-
Sato Y, Yokokawa M, Harada H, Ikeda T, Michi Y, Kashima Y, Kayamori K, Kuroshima T, Hiral H, Okuyama K, Tsuchiya M, Tomioka H, and Yamagata Y
- Subjects
Minor Salivary Glands ,Pathology ,medicine.medical_specialty ,medicine ,Biology ,medicine.disease ,Epithelial-myoepithelial carcinoma - Abstract
Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland tumor, which is especially uncommon in the minor salivary glands (MSG). We report literature review of EMC of the MSGs with our experience of two cases. Case 1 is a 75-year-old woman with a hard elastic mass in the hard palate, sized 2.5 × 2 cm without ulceration. Incisional biopsy was suggestive of pleomorphic adenoma. Tumor resection was performed with adequate surgical margin. Case 2 is a 44-year-old woman with a mass in the hard palate, sized 1.8 × 1.6 cm without ulceration. Incisional biopsy was suggestive of pleomorphic adenoma or a low-grade salivary gland carcinoma and intraoral tumor resection was performed. Both have good postoperative courses and are alive with no evidence of local recurrence or metastasis at 25 and 10 months. The Ki-67 labeling index in Case 1 and 2 were 10.6 and 3.8 %. Considering that the anatomy, structure, and size of salivary glands are quite different from MSGs, EMCs of the MSG cannot be predicted similarly to EMCs of the major salivary glands. The present review with 18 cases revealed no consensus on treatment methods for MSG cases other than surgery.
- Published
- 2021
6. A Targeted Genetic Association Study of the Rare Type of Osteomyelitis
- Author
-
Yahara, H., primary, Horita, S., additional, Yanamoto, S., additional, Kitagawa, Y., additional, Asaka, T., additional, Yoda, T., additional, Morita, K., additional, Michi, Y., additional, Takechi, M., additional, Shimasue, H., additional, Maruoka, Y., additional, Kondo, E., additional, Kusukawa, J., additional, Tsujiguchi, H., additional, Sato, T., additional, Kannon, T., additional, Nakamura, H., additional, Tajima, A., additional, Hosomichi, K., additional, and Yahara, K., additional
- Published
- 2020
- Full Text
- View/download PDF
7. Human oral squamous cell carcinoma cell lines promote angiogenesis via expression of vascular endothelial growth factor and upregulation of KDR/flk-1 expression in endothelial cells
- Author
-
Michi, Y., Morita, I., Amagasa, T., and Murota, S.
- Published
- 2000
- Full Text
- View/download PDF
8. Clinical study on mandibular fracture after marginal resection of the mandible
- Author
-
Okuyama, K., primary, Michi, Y., additional, Yamashiro, M., additional, and Harada, K., additional
- Published
- 2014
- Full Text
- View/download PDF
9. Survival and prognostic factors in patients with advanced-stage tongue cancer
- Author
-
Yamashiro, M., primary, Hasegawa, K., additional, Uzawa, N., additional, Michi, Y., additional, Yamane, M., additional, Isii, J., additional, Suzuki, M., additional, and Amagasa, T., additional
- Published
- 2009
- Full Text
- View/download PDF
10. Efficiency of clinical pathway for swallowing disorders due to oral tumour resection and reconstruction
- Author
-
Nakakuki, K., primary, Mitsunaga, S., additional, Yokomizo, I., additional, Nakane, A., additional, Murata, S., additional, Tohara, H., additional, Michi, Y., additional, Yamane, M., additional, Yamashiro, M., additional, and Amagasa, T., additional
- Published
- 2009
- Full Text
- View/download PDF
11. Treatment strategies for patients over 80 years of age with oral squamous cell carcinoma.
- Author
-
Hirai H, Kinoshita N, Nishii N, Oikawa Y, Kugimoto T, Kuroshima T, Tomioka H, Michi Y, Sumita Y, Tomihara K, and Harada H
- Abstract
Objective: To analyze the clinical characteristics of patients with oral squamous cell carcinoma aged ≥80 years, focusing on surgical treatments., Study Design: We reviewed patients with oral squamous cell carcinoma aged ≥80 years who underwent surgery between 2005 and 2018. Basic information, comorbidities, multiple primary cancers, initial treatment, complications, and outcomes were evaluated., Results: Of 197 patients aged ≥80 years, 119 patients underwent surgery (50 males, 69 females; mean age: 83.5 years). The gingiva was the most common primary tumor site (63 patients, 52.9 %). The stage classification was stage I in 35 patients (29.4 %), stage II in 44 (37 %), stage III in 16 (13.4 %), stage IVA in 22 (18.5 %), and stage IVB in 2 (1.7 %). Comorbidities were identified in 112 patients (94.1 %). Surgery was the initial treatment in 111 patients (93.3 %). Eight (6.7 %) patients received postoperative adjuvant chemotherapy/radiotherapy; 20 patients (16.8 %) underwent free tissue transplantation. Perioperative complications were observed in 36 patients (30.3 %). The cumulative 5-year and 10-year overall survival rates were 82 % and 68.3 %, respectively; the disease-specific survival rates were 90 %., Conclusion: Good treatment outcomes were obtained with radical surgery. Surgery should be the first choice if quality of life is assured and there are no issues with surgical tolerance, regardless of age., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
12. Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern.
- Author
-
Kugimoto T, Nishii N, Oikawa Y, Kuroshima T, Hirai H, Tomioka H, Michi Y, Kayamori K, Sakamoto J, Iwanaga J, Tubbs RS, Ikeda T, Miura M, and Harada H
- Abstract
Background: This study aimed to determine the patterns of invasion of oral squamous cell carcinoma (OSCC) into the bucco-mandibular space (BMS) using detailed histopathological analysis and to assess clinical outcomes., Methods: Patients with OSCC who underwent segmental mandibulectomy or hemi-mandibulectomy combined with resection of the BMS between 2012 and 2021 were included. The invasions of the BMS were classified into three patterns. Pattern A was defined as a horizontal invasion, Pattern B as a vertical invasion, and Pattern C as an expansive invasion., Results: In total, 109 patients were reviewed. Of these 109 patients, the primary tumor affected the lower gingiva in 78 patients, the buccal mucosa in 18 patients, and was a primary intraosseous carcinoma of the mandible in 13 patients. Invasion of the BMS was significantly associated with a higher pathological T stage, positive/close margins, and lower disease-free survival (DFS) rates. The DFS rates were 86.7% and 66.0% in the BMS non-invasion and invasion groups, respectively. The DFS rates for each type of invasion were 82.1% for Pattern A, 67.4% for Pattern B, and 48.0% for Pattern C (P=0.277)., Conclusion: Patients with BMS invasion have a poorer prognosis than those without invasion of the BMS. Therefore, adjuvant therapy is necessary, especially in Patterns B and C. Evaluation of preoperative BMS invasion patterns is important for predicting the prognosis of OSCC., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Kugimoto, Nishii, Oikawa, Kuroshima, Hirai, Tomioka, Michi, Kayamori, Sakamoto, Iwanaga, Tubbs, Ikeda, Miura and Harada.)
- Published
- 2023
- Full Text
- View/download PDF
13. Buccinator muscle invasion is a risk factor for cervical lymph node metastasis in squamous cell carcinoma of the buccal mucosa: A retrospective study.
- Author
-
Hirai H, Nishii N, Oikawa Y, Ohsako T, Kugimoto T, Kuroshima T, Tomioka H, Michi Y, Kayamori K, Ikeda T, and Harada H
- Abstract
The present study aimed to determine the risk factors associated with cervical lymph node metastasis (CLNM) in patients with buccal mucosa squamous cell carcinoma (BMSCC). This retrospective study included patients with primary BMSCC who underwent surgery at the Department of Oral and Maxillofacial Surgical Oncology of Tokyo Medical and Dental University (Tokyo, Japan) between January 2008 and December 2017. The following data were collected and analyzed: Sex, age, primary lesion subsite, tumor/node/metastasis stage, clinical growth patterns, tumor differentiation, lymphovascular and perineural invasion, mode of invasion, pathological depth of invasion, extent of tumor invasion, and clinical outcome of patients with BMSCC. Multivariate analysis was performed to identify the possible risk factors for CLNM. A total of 75 patients were included in the present study, among whom 30 (40%) were found to have histological CLNM. Of the 33 patients with buccinator muscle infiltration by the tumor, 24 (72.7%) had CLNM. Multiple logistic regression analysis revealed that buccinator muscle invasion was the most significant predictive risk factor for CLNM in BMSCC. The present study found that tumor invasion of the buccinator muscle was the most significant predictive risk factor for CLNM in BMSCC. Therefore, elective neck dissection should be performed if buccinator muscle invasion is identified in patients with BMSCC., Competing Interests: The authors declare that they have no competing interests., (Copyright: © Hirai et al.)
- Published
- 2023
- Full Text
- View/download PDF
14. Determination of Significant Prognostic Factors for Maxillary Gingival Squamous Cell Carcinoma in 90 Cases.
- Author
-
Ohyama Y, Yamashiro M, Michi Y, Uzawa N, Myo K, Sonoda I, Sumino J, Miura C, Mizutani M, Yamamoto D, Kayamori K, and Yoda T
- Abstract
Maxillary gingival squamous cell carcinoma (MGSCC) occurs rather infrequently, compared to tongue and mandibular gingival carcinomas, among the cancers of the oral cavity. Therefore, significant numbers of MGSCC cases have not been statistically analysed. The aim of this study is to clarify the prognostic factors for MGSCC. We performed the statistical analysis of 90 MGSCC cases primarily treated in our department from 1999 to 2014. The patients (male: 36, female: 54) were aged between 38 and 93 years, and the mean age was 68.7 years. The number of patients in each tumour stage according to the TNM classification was as follows: T1: 15 cases, T2: 32 cases, T3: 13 cases, and T4: 30 cases. Forty-two patients were treated only by surgery, 5 only by radiotherapy, 3 by preoperative radiotherapy and surgery, and 40 patients were treated by combination therapy with preoperative chemoradiotherapy and surgery. Neck dissections were performed in 40 cases including 29 cases (11 primary and 18 secondary cases) of histopathologically diagnosed lymph node metastases. Extranodal extension was found in 74.3% cases with metastatic lymph nodes. The 5-year overall survival rate was 81.9%. In univariate analysis, the site of occurrence, stage of tumour, lymph node metastasis, and treatment contributed to the 5-year survival rate. Multivariate analysis demonstrated that the site of occurrence (posterior region) was an independent prognostic factor. Seventeen deaths occurred due to the primary disease, while three deaths were caused by other diseases. The posterior region cancers, according to the classification based on site of occurrence, were independent predictors of poor 5-year overall survival rate., Competing Interests: Conflict of interestsThe authors have no conflicts of interest to declare that are relevant to the content of this article., (© Association of Otolaryngologists of India 2021.)
- Published
- 2022
- Full Text
- View/download PDF
15. High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma.
- Author
-
Komiyama T, Kuroshima T, Sugasawa T, Fujita SI, Ikami Y, Hirai H, Tsushima F, Michi Y, Kayamori K, Higashino F, and Harada H
- Subjects
- Humans, Lymphatic Metastasis, Phenotype, Vimentin genetics, Adaptor Proteins, Signal Transducing genetics, DNA-Binding Proteins genetics, Mouth Neoplasms genetics, Mouth Neoplasms pathology, RNA-Binding Proteins genetics, Squamous Cell Carcinoma of Head and Neck pathology
- Abstract
The present study aimed to investigate the clinical and biological significance of Src‑associated in mitosis 68 kDa (Sam68) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis was performed on tissue samples obtained from 77 patients with OSCC. Univariate analysis revealed that the high expression of Sam68 was significantly correlated with advanced pathological T stage (P=0.01), positive lymphovascular invasion (P=0.01), and pathological cervical lymph node metastasis (P<0.01). Moreover, multivariate analysis demonstrated that the high expression of Sam68 was an independent predictive factor for cervical lymph node metastasis (odds ratio, 4.39; 95% confidence interval, 1.49‑14.23; P<0.01). These results indicated that high Sam68 expression contributed to tumor progression, especially cervical lymph node metastasis, in OSCC. mRNA sequencing was also performed to assess the changes in the transcriptome between OSCC cells with Sam68 knockdown and control cells with the aim of elucidating the biological roles of Sam68. Gene Ontology enrichment analysis revealed that downregulated differentially expressed genes (DEGs) were concentrated in some biological processes related to epithelial‑mesenchymal transition. Among these DEGs, it was established that vimentin was particularly downregulated in these cells. It was also confirmed that Sam68 knockdown reduced the motility of OSCC cells. Furthermore, the immunohistochemical study of vimentin identified the association between vimentin expression and Sam68 expression as well as cervical lymph node metastasis. In conclusion, the present study suggested that the high expression of Sam68 may contribute to metastasis by regulating vimentin expression and a motile mesenchymal phenotype in OSCC.
- Published
- 2022
- Full Text
- View/download PDF
16. Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study).
- Author
-
Yanamoto S, Michi Y, Otsuru M, Inomata T, Nakayama H, Nomura T, Hasegawa T, Yamamura Y, Yamada SI, Kusukawa J, Yamakawa N, Hasegawa O, Ueda M, Kitagawa Y, Hiraki A, Hasegawa T, Ohiro Y, Kobayashi W, Asoda S, Kobayashi T, Iino M, Fukuda M, Ishibashi-Kanno N, Kawaguchi K, Aijima R, Noguchi K, Okura M, Tanaka A, Sugiura T, Shintani Y, Yagihara K, Yamashiro M, Ota Y, Miyazaki A, Takeshita A, Kawamata H, Hiroshi I, Uchida K, Umeda M, Kurita H, and Kirita T
- Subjects
- Humans, Neck Dissection methods, Neoplasm Recurrence, Local surgery, Prospective Studies, Quality of Life, Squamous Cell Carcinoma of Head and Neck surgery, Carcinoma, Squamous Cell, Head and Neck Neoplasms surgery, Tongue Neoplasms pathology, Tongue Neoplasms surgery
- Abstract
Introduction: In early-stage oral tongue squamous cell carcinoma (OTSCC), elective neck dissection (END) is recommended when occult lymph node metastasis is suspected; however, there is no unanimous consensus on the risks and benefits of END in such cases. The management of clinically node-negative (cN0) OTSCC remains controversial. This study, therefore, aimed to evaluate the efficacy of END and its impact on the quality of life (QoL) of patients with cN0 OTSCC., Methods and Analysis: This is a prospective, multicentre, nonrandomised observational study. The choice of whether to perform END at the same time as resection of the primary tumour is based on institutional policy and patient preference. The primary endpoint of this study is 3-year overall survival. The secondary endpoints are 3-year disease-specific survival, 3-year relapse-free survival and the impact on patient QoL. Propensity score-matching analysis will be performed to reduce selection bias., Ethics and Dissemination: This study was approved by the Clinical Research Review Board of the Nagasaki University. The protocol of this study was registered at the University Hospital Medical Information Network Clinical Trials Registry. The datasets generated during the current study will be available from the corresponding author on reasonable request. The results will be disseminated internationally, through scientific and professional conferences and in peer-reviewed medical journals., Trial Registration Number: UMIN000027875., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
- Full Text
- View/download PDF
17. Comprehensive Genomic Profiling Reveals Clinical Associations in Response to Immune Therapy in Head and Neck Cancer.
- Author
-
Noji R, Tohyama K, Kugimoto T, Kuroshima T, Hirai H, Tomioka H, Michi Y, Tasaki A, Ohno K, Ariizumi Y, Onishi I, Suenaga M, Mori T, Okamoto R, Yoshimura R, Miura M, Asakage T, Miyake S, Ikeda S, Harada H, and Kano Y
- Abstract
Comprehensive genomic profiling (CGP) provides information regarding cancer-related genetic aberrations. However, its clinical utility in recurrent/metastatic head and neck cancer (R/M HNC) remains unknown. Additionally, predictive biomarkers for immune checkpoint inhibitors (ICIs) should be fully elucidated because of their low response rate. Here, we analyzed the clinical utility of CGP and identified predictive biomarkers that respond to ICIs in R/M HNC. We evaluated over 1100 cases of HNC using the nationwide genetic clinical database established by the Center for Cancer Genomics and Advanced Therapeutics (C-CAT) and 54 cases in an institution-based study. The C-CAT database revealed that 23% of the cases were candidates for clinical trials, and 5% received biomarker-matched therapy, including NTRK fusion. Our institution-based study showed that 9% of SCC cases and 25% of salivary gland cancer cases received targeted agents. In SCC cases, the tumor mutational burden (TMB) high (≥10 Mut/Mb) group showed long-term survival (>2 years) in response to ICI therapy, whereas the PD-L1 combined positive score showed no significant difference in progression-free survival. In multivariate analysis, CCND1 amplification was associated with a lower response to ICIs. Our results indicate that CGP may be useful in identifying prognostic biomarkers for immunotherapy in patients with HNC.
- Published
- 2022
- Full Text
- View/download PDF
18. Clinical manifestations of diffuse large B-cell lymphoma that exhibits initial symptoms in the maxilla and mandible: a single-center retrospective study.
- Author
-
Michi Y, Harada H, Oikawa Y, Okuyama K, Kugimoto T, Kuroshima T, Hirai H, Mochizuki Y, Shimamoto H, Tomioka H, Kachi H, Sakamoto JI, Kayamori K, and Yoda T
- Subjects
- Humans, Mandible pathology, Prognosis, Retrospective Studies, Lymphoma, Large B-Cell, Diffuse diagnosis, Lymphoma, Large B-Cell, Diffuse drug therapy, Lymphoma, Large B-Cell, Diffuse pathology, Maxilla pathology
- Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphatic tumor; however, extranodal DLBCLs that exhibit initial symptoms in the maxilla and mandible are rare. Moreover, DLBCL is clinically classified as a moderate to highly malignant lymphatic tumor that can progress rapidly; therefore, early diagnosis is crucial. However, diagnosis is difficult as the disease causes a diverse range of clinical symptoms with no characteristic imaging findings. We conducted a clinical investigation to clarify the clinical characteristics of DLBCL that exhibits initial manifestation in the maxilla and mandible., Methods: Of the 2748 patients with malignant tumors of the oral and maxillofacial region examined at our hospital during a period of 11 years between January 2006 and December 2016, 27 primary cases diagnosed with DLBCL based on the chief complaint of symptoms in the gingiva and bone of the maxilla and mandible were enrolled in this study. Evaluations were based on sex, age, whether treatment was provided by a previous physician, symptoms, duration of disease until treatment was sought, clinical diagnosis, laboratory findings, and imaging results., Results: There were 15 cases that involved the maxilla and 12 that involved the mandible. The median duration of disease until treatment was sought was 60 d (3-450 d). All cases exhibited a tumor or a mass, and hypoesthesia of the chin was confirmed in eight cases wherein the mandible was involved. The clinical stages were stage I in eight cases, stage II in ten cases, and stage IV in nine cases. Serum lactate dehydrogenase (LDH) levels were elevated in 13 of 22 patients. The overall survival rate was 63%., Conclusions: Symptoms associated with nontender swelling and numbness of the lip or chin in the absence of other findings such as dental infections should raise suspicions about DLBCL. Patients should be provided appropriate imaging and accurate biopsy assessments to improve prognosis., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
19. Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review.
- Author
-
Okuyama K, Michi Y, Kashima Y, Tomioka H, Hirai H, Yokokawa M, Yamagata Y, Kuroshima T, Sato Y, Tsuchiya M, Kayamori K, Ikeda T, and Harada H
- Abstract
Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells, which is especially uncommon in the minor salivary glands (MSG). Because of its histologic variety, complexity, and heterogeneity, it is sometimes challenging to make the accurate diagnosis. Here, we report a literature review of EMC of the MSGs with our experience of two cases. Incisional biopsy was suggestive of pleomorphic adenoma in Case 1 and pleomorphic adenoma or a low-grade salivary gland carcinoma in Case 2. Both cases were performed intraoral tumor resection, and they have good postoperative courses and are alive with no evidence of local recurrence or metastasis at 31 and 16 months, respectively. Considering that the anatomy, structure, and size of salivary glands are quite different from MSGs, it might be difficult to predict EMCs of the MSG similarly to EMCs of the major salivary glands. This comprehensive review also reports the features of EMC of the MSG cases and the trends of diagnosis and discusses treatment strategy.
- Published
- 2021
- Full Text
- View/download PDF
20. Prognostic impact of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue: a retrospective study.
- Author
-
Kuroshima T, Onozato Y, Oikawa Y, Ohsako T, Kugimoto T, Hirai H, Tomioka H, Michi Y, Miura M, Yoshimura R, and Harada H
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Prognosis, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck diagnosis, Squamous Cell Carcinoma of Head and Neck mortality, Tokyo epidemiology, Tongue Neoplasms diagnosis, Tongue Neoplasms mortality, Young Adult, Lymph Nodes pathology, Squamous Cell Carcinoma of Head and Neck pathology, Tongue Neoplasms pathology
- Abstract
Squamous cell carcinoma (SCC) of the tongue rarely metastasizes to the lingual lymph nodes (LLNs), which are inconstant nodes and often situated outside the areas of basic tongue tumor surgery. The current study evaluated the clinicopathological features and prognostic impact of LLN metastasis (LLNM), compared to that of cervical lymph node metastasis, in patients with tongue SCC. A total of 608 patients underwent radical surgery for tongue SCC at our department between January 2001 and December 2016. During neck dissection, we scrutinized and resected lateral LLNs, when present. Of the 128 patients with lymph node metastasis, 107 had cervical lymph node metastasis and 21 had both cervical lymph node metastasis and LLNM. Univariate analysis demonstrated that LLNM was significantly associated with the adverse features of cervical lymph node metastasis. The 5-year disease-specific survival (5y-DSS) was significantly lower in patients with LLNMs than in those without LLNMs (49.0% vs. 88.4%, P < 0.01). Moreover, Cox proportional hazards model analyses revealed that cervical lymph node metastasis at level IV or V and LLNM were independent prognostic factors for 5y-DSS. LLNM has a strong negative impact on survival in patients with tongue SCC. An advanced status of cervical lymph node metastasis may predict LLNM., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
21. Multicenter retrospective analysis of clinicopathological features and prognosis of oral tongue squamous cell carcinoma in adolescent and young adult patients.
- Author
-
Okuyama K, Yanamoto S, Michi Y, Shibata E, Tsuchiya M, Yokokawa M, Naruse T, Tomioka H, Kuroshima T, Shimamoto H, Ikeda T, Umeda M, Yoda T, and Harada H
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell mortality, Case-Control Studies, Disease-Free Survival, Elective Surgical Procedures methods, Female, Humans, Male, Neck Dissection trends, Neoplasm Staging methods, Retrospective Studies, Therapeutics methods, Young Adult, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell surgery, Neck Dissection methods, Tongue Neoplasms pathology
- Abstract
Abstract: The aim of this study is to report the differences in clinicopathological features of oral tongue squamous cell carcinoma (OTSCC) and survival between adolescent and young adult (AYA) patients and elderly patients and to find the prognosticators. The medical records of 101 AYA patients and 175 control patients with OTSCC who underwent surgery were reviewed. Variables related to prognosis and their clinicopathological associations were analyzed. The 5-year overall survival (5y-OS) rates of AYA and control patients with stage I and II OTSCC were 94.4% and 89.6% (P = .353), respectively, and their 5-year disease-free survival (5y-DFS) rates were 82.0% and 76.6%, respectively (P = .476). The 5y-OS rates of patients with stages III and IV OTSCC were 83.3% and 66.7% (P = .333), respectively, and their 5y-DFS rates were 75.0% and 57.1% (P = .335), respectively. Logistic regression analysis revealed that there was no significant clinicopathological difference in AYA and control group. Furthermore, there was no significant difference in 5y-OS rates between patients who underwent elective neck dissection (END) and those who underwent therapeutic neck dissection (TND) in both group (P = 0.717 and 0.688). Overall, the present study revealed the clinicopathological features and prognosis of OTSCC were similar in AYA patients and elderly patients. Moreover, as there was no significant difference in OS between patients who underwent END and those who underwent TND in AYA and control groups, our results suggest that the indication for END in AYA patients with clinical N0 OTSCC is similar to that for elderly patients., Competing Interests: The authors have no funding and conflicts of interest to disclose., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2021
- Full Text
- View/download PDF
22. Detection of novel fusion genes by next-generation sequencing-based targeted RNA sequencing analysis in adenoid cystic carcinoma of head and neck.
- Author
-
Shibata E, Morita KI, Kayamori K, Tange S, Shibata H, Harazono Y, Michi Y, Ikeda T, Harada H, Imoto I, and Yoda T
- Subjects
- High-Throughput Nucleotide Sequencing, Humans, Oncogene Proteins, Fusion genetics, Proto-Oncogene Proteins, Sequence Analysis, RNA, Trans-Activators genetics, Carcinoma, Adenoid Cystic genetics, Salivary Gland Neoplasms genetics
- Abstract
Objective: Adenoid cystic carcinoma (AdCC) is a rare, indolent salivary gland tumor that is reported to be driven by fusion genes. However, MYB/MYBL1-NFIB fusions have been detected in <60% of all AdCC cases and the oncogenic driver mutations in approximately 40% of AdCC remain unknown. Our aim was to identify novel gene fusions in AdCC., Study Design: We investigated 20 AdCC cases using a targeted RNA sequencing panel to identify gene fusions and performed quantitative real-time reverse transcription polymerase chain reaction to assess MYB, MYBL1, and NFIB expression levels., Results: A total of 36 fusion transcripts in 15 cases were detected and validated by Sanger sequencing. The MYB-NFIB and MYBL1-NFIB fusion genes were detected in 9 and 3 cases, respectively, in a mutually exclusive manner. Furthermore, novel gene fusions, namely, NFIB-EPB41L2, MAP7-NFIB, NFIB-MCMDC2, MYBL1-C8orf34, C8orf34-NFIB, and NFIB-CASC20, were identified. Among them, NFIB-EPB41L2 and NFIB-MCMDC2 are thought to activate MYB and MYBL1 expression, respectively, through the insertion of a genomic segment in proximity to MYB and MYBL1 genes, respectively., Conclusion: Six novel gene fusions other than MYB/MYBL1-NFIB were identified. The detection of novel fusion genes and investigation of the molecular mechanism will contribute to the development of novel molecular targeted therapies for this disease., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
23. Mandibular Reconstruction with Scapular Systems: A Single-Center Case Series Involving 208 Flaps.
- Author
-
Harada H, Shimamoto H, Oikawa Y, Kuroshima T, Tomioka H, Hirai H, Tsushima F, and Michi Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Free Tissue Flaps adverse effects, Humans, Male, Mandible pathology, Mandible surgery, Mandibular Neoplasms pathology, Mandibular Reconstruction adverse effects, Middle Aged, Necrosis epidemiology, Necrosis etiology, Necrosis pathology, Osteotomy adverse effects, Postoperative Complications etiology, Postoperative Complications pathology, Retrospective Studies, Treatment Outcome, Young Adult, Free Tissue Flaps transplantation, Mandibular Neoplasms surgery, Mandibular Reconstruction methods, Postoperative Complications epidemiology, Scapula transplantation
- Abstract
Background: The scapular flap is the most versatile composite flap used for mandibular reconstruction. The purpose of this study was to review and summarize findings of cases of mandibular reconstruction with a scapular flap and describe associated outcomes and complications., Methods: A total of 208 microvascular scapular free flaps were performed for mandibular reconstruction in a total of 205 patients from 2003 to 2018. This study involved a retrospective review of all eligible patients' medical records., Results: There were seven cases (3.4 percent) of microvascular thrombosis. Postoperative bone union was achieved by 201 patients, except for five with total flap necrosis and two with partial flap necrosis. There were four cases (1.9 percent) of mandibular condyle dislocation. Two major types of complications were observed at the donor site, including four cases of infection and six cases of scapular body fracture. Postoperative denture prosthesis was introduced to 97 patients (47.3 percent). Implant treatment was performed in 10 patients (4.9 percent). Functional and aesthetic outcomes were good to excellent., Conclusions: The scapular composite free flap for mandibular reconstruction was associated with favorable outcomes and demonstrated satisfactory results. Although scapular bone fracture is rare, patients who have undergone mandibular reconstruction using a scapular flap should be monitored for its presence. ., Clinical Question/level of Evidence: Therapeutic, IV., (Copyright © 2021 by the American Society of Plastic Surgeons.)
- Published
- 2021
- Full Text
- View/download PDF
24. Ramucirumab-related Oral Pyogenic Granuloma: A Report of Two Cases.
- Author
-
Aragaki T, Tomomatsu N, Michi Y, Hosaka H, Fukai Y, Iijima M, and Yoda T
- Subjects
- Aged, Antibodies, Monoclonal, Humanized adverse effects, Humans, Lip, Male, Middle Aged, Mouth Mucosa, Ramucirumab, Granuloma, Pyogenic chemically induced, Granuloma, Pyogenic diagnosis
- Abstract
Pyogenic granuloma (PG) is a granulomatous elevated lesion that occurs on the skin and mucous membranes. We herein report two cases of intra-oral PG that developed during the administration of ramucirumab for gastric cancer. Case 1 involved a 55-year-old man with a 6-mm tumor on the right tongue, and case 2 involved a 67-year-old man with a 5-mm tumor on the upper lip. The imbalance in angiogenesis caused by ramucirumab and the deterioration in the local oral environment were suggested to have caused the PG. Medical and dental collaboration is essential during the administration of ramucirumab.
- Published
- 2021
- Full Text
- View/download PDF
25. Non-surgical treatment for periodontitis and peri-implantitis: longitudinal clinical and bacteriological findings-A case report with a 7-year follow-up evaluation.
- Author
-
Shiba T, Watanabe T, Komatsu K, Koyanagi T, Nemoto T, Ohsugi Y, Michi Y, Katagiri S, Takeuchi Y, Ishihara K, and Iwata T
- Abstract
The aim of this report is to show that periodontitis and peri-implantitis with horizontal bone resorption in a 68-year-old male patient were successfully treated by non-surgical treatment. Scaling with an ultrasonic device was performed for moderate periodontitis around the mandibular left first premolar and moderate peri-implantitis around the maxillary right molar implants. Root planing with a metal curette was performed for the periodontal site, and debridement with a plastic curette was performed for the peri-implant site. A month after treatment, probing depth decreased from 5 to 2 mm at the periodontal site and 8 to 3 mm at the peri-implant site. The investigation of bacterial composition by sequencing the 16S rRNA gene amplicons showed that the composition similarly changed at both sites, 5 years after treatment; the change reflected the typical recovery of periodontitis. The clinical condition was maintained for 7 years after treatment at both sites. This was a successful case of non-surgical treatment for peri-implantitis with horizontal bone resorption, promoting recovery of the microbiota from dysbiotic shift., Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2021.)
- Published
- 2021
- Full Text
- View/download PDF
26. Surgical treatment for oral tongue squamous cell carcinoma: A retrospective study of 432 patients.
- Author
-
Oikawa Y, Kugimoto T, Kashima Y, Okuyama K, Ohsako T, Kuroshima T, Hirai H, Tomioka H, Shimamoto H, Michi Y, and Harada H
- Abstract
The incidence of oral cancer in Japan accounts for 1% of all cancers, with oral tongue cancer accounting for 60% of oral cancers based on the subsite. The most common histologic type is squamous cell carcinoma. This study aimed to evaluate the series of surgical treatments for 432 patients with oral tongue squamous cell carcinoma (OTSCC). Initial surgical treatments for the primary site included partial glossectomy, hemiglossectomy, and total or subtotal glossectomy in 348, 58, and 26 patients, respectively. Therapeutic neck dissection, elective neck dissection, and subsequent neck dissection were performed in 74, 53, and 37 patients, respectively. Patients with advanced cases had level IIb, IV, and V metastasis and outside regional lymph node metastases. The cumulative 5-year disease-specific survival rate for OTSCC was 92.8%, and the rates for each stage were 96.6%, 93.9%, 84.1%, and 79.0% in stages I, II, III, and IV, respectively. The recurrence rate, overall salvage rate for recurrent cases, and rate for the additional surgical group were 10.4%, 46.7%, and 78.6%, respectively. Patients with multiple cervical lymph node metastases, extranodal extension, metastases to multiple levels, and lower neck metastases had poor prognosis. In conclusion, careful follow-up is necessary to detect recurrence of primary tumors at a stage when surgical treatment can be performed, and cervical lymph node status is one of the most important prognostic factors in OTSCC., Competing Interests: The authors have no conflicts of interest to disclose., (2021, National Center for Global Health and Medicine.)
- Published
- 2021
- Full Text
- View/download PDF
27. Comparison of Clinicopathological Characteristics Between the Anterior and Posterior Type of Squamous Cell Carcinoma of the Floor of the Mouth: The Anterior Type Is a Risk Factor for Multiple Primary Cancer.
- Author
-
Oikawa Y, Tanaka K, Ohsako T, Kugimoto T, Kuroshima T, Hirai H, Tomioka H, Shimamoto H, Michi Y, Sakamoto K, Ikeda T, and Harada H
- Abstract
Background: Floor of the mouth (FOM) squamous cell carcinoma (SCC) accounts for approximately 10% of all oral SCCs. FOM SCC can be classified into the anterior and posterior types according to their site of origin, but few studies have compared these types. This study sought to clarify differences in clinicopathological characteristics between these two types., Methods: A total of 1,220 patients with oral SCC were treated at our department from January 2001 to December 2015. Among these patients, 62 had FOM SCC. The FOM SCCs were classified into two groups: the anterior type and the posterior type. The anterior and posterior types were defined by the boundary connecting the spaces between the canine and the first premolar bilaterally. We retrospectively compared the sex, age, smoking and drinking history, clinical stage, treatment, histopathological diagnosis, multiple primary cancers, and outcomes of the two groups., Results: Among the 62 patients, 32 had the anterior type, while 30 had the posterior type. The anterior type was found more significantly in men ( p = 0.01) and individuals with a smoking history than the posterior type ( p = 0.04). pN2-3 cervical lymph node metastasis was significantly more common in the anterior type than in the posterior type ( p = 0.01). The median depth of invasion in the anterior type was 4 mm. Multivariate analysis showed that the anterior type was an independent risk factor for multiple primary cancer development in FOM SCC ( p = 0.02). The cumulative 10-year disease-specific survival rates of the anterior and posterior types were 92.8 and 95.0%, respectively, while the overall survival rates were 65.4 and 95.0%, respectively. In the anterior type FOM SCC, a lower overall survival rate was associated with multiple primary cancers and smoking-related diseases., Conclusion: Smoking cessation and adequate systemic screening for multiple primary cancers are needed to improve the prognosis of FOM SCC, particularly the anterior type., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Oikawa, Tanaka, Ohsako, Kugimoto, Kuroshima, Hirai, Tomioka, Shimamoto, Michi, Sakamoto, Ikeda and Harada.)
- Published
- 2021
- Full Text
- View/download PDF
28. Case Report: Hidden Oral Squamous Cell Carcinoma in Oral Somatic Symptom Disorder.
- Author
-
Suga T, Tu TTH, Takenoshita M, Mikuzuki L, Umezaki Y, Shimamoto H, Michi Y, Hong C, Abiko Y, Ikeda T, Uzawa N, Harada H, and Toyofuku A
- Abstract
Background: Burning mouth syndrome (BMS) is a common condition of predominant oral pain without evident cause, that maxillofacial surgeons and otolaryngologists often refer to psychiatrists as somatic symptom disorder. In very rare cases, its typical burning symptom mimics those of other diseases in which serious fatal comorbidities may be missed. We encountered three rare cases of oral squamous cell carcinoma (OSCC) with the first symptom of burning tongue. Case Presentation: Case 1: A 68-year-old woman had burning pain on the left lingual margin for 8 years. Antidepressant treatment was not efficacious. Cytology and biopsy revealed OSCC. Case 2: A 70-year-old man had burning sensation and paralysis of the tongue for 6 months. Magnetic resonance imaging (MRI) revealed a 37 × 23-mm mass under the floor of the mouth and enlargement of lymph nodes on both sides. Case 3: A 90-year-old man had burning sensation of the tongue for 1 year. MRI revealed a 12 × 12-mm mass on the mandible with bone absorption. Conclusion: This case series suggests that psychiatrists must always be careful in regarding BMS as somatic symptom disorder and be cautious of the possibility of OSCC, especially in elderly patients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Suga, Tu, Takenoshita, Mikuzuki, Umezaki, Shimamoto, Michi, Hong, Abiko, Ikeda, Uzawa, Harada and Toyofuku.)
- Published
- 2021
- Full Text
- View/download PDF
29. Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma.
- Author
-
Tran CM, Kuroshima T, Oikawa Y, Michi Y, Kayamori K, and Harada H
- Abstract
Pigmented oral squamous cell carcinoma (POSCC) is a rare and underrecognized pathological variant of oral squamous cell carcinoma (OSCC). The current study aimed to evaluate the clinicopathological characteristics, treatment outcomes and prognosis of patients with POSCC and to investigate its oncological properties using immunohistochemical studies. A total of 1,512 patients were pathologically diagnosed with squamous cell carcinoma of the oral cavity, and were treated at the Department of Oral and Maxillofacial Surgery, Tokyo Medical and Dental University between January 2001 and December 2018. A total of 25 patients had POSCC and underwent radical surgery. Of these 25 patients, 23 presented with early T stage disease. Additionally, 22 patients were negative for cervical lymph nodes metastasis. Only one patient had local recurrence. The 5-year disease-free and disease-specific survival rates were 86.6 and 95.8%, respectively. Immunohistochemically, a high percentage of POSCC exhibited low p53 and Ki-67, preserved E-cadherin or negative vimentin expression. The results suggested that POSCC tends to exhibit non-aggressive oncological behavior and demonstrates a good prognosis., Competing Interests: The authors declare that they have no competing interests., (Copyright: © Tran et al.)
- Published
- 2021
- Full Text
- View/download PDF
30. Nodular lymphocyte-predominant Hodgkin lymphoma involving the hard palate.
- Author
-
Fukawa Y, Sakamoto K, Kugimoto T, Michi Y, Harada H, Yamamoto M, Kitagawa M, Ikeda T, and Yamamoto K
- Subjects
- Aged, 80 and over, CD57 Antigens analysis, Female, Hodgkin Disease pathology, Humans, Lymph Nodes pathology, Lymphocytes metabolism, Lymphocytes pathology, Palate, Hard pathology, Hodgkin Disease diagnosis
- Published
- 2021
- Full Text
- View/download PDF
31. Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma.
- Author
-
Baba S, Akashi T, Kayamori K, Ohuchi T, Ogawa I, Kubota N, Nakano K, Nagatsuka H, Hasegawa H, Matsuzaka K, Tomii S, Uchida K, Katsuta N, Sekiya T, Ando N, Miura K, Ishibashi H, Ariizumi Y, Asakage T, Michi Y, Harada H, Sakamoto K, Eishi Y, Okubo K, and Ikeda T
- Subjects
- Adenoma diagnosis, Adenoma metabolism, Adenoma pathology, Adenoma, Pleomorphic diagnosis, Adenoma, Pleomorphic metabolism, Adenoma, Pleomorphic pathology, Carcinoma, Adenoid Cystic metabolism, Carcinoma, Adenoid Cystic pathology, Diagnosis, Differential, Humans, Immunohistochemistry, ROC Curve, Salivary Gland Neoplasms metabolism, Salivary Gland Neoplasms pathology, Sensitivity and Specificity, Biomarkers, Tumor metabolism, Carcinoma, Adenoid Cystic diagnosis, Homeodomain Proteins metabolism, Salivary Gland Neoplasms diagnosis
- Abstract
Diagnostic utility of a homeobox transcription factor, engrailed homeobox 1 (En1) in the histopathology of salivary gland neoplasms was studied. The expression of En1 was immunohistochemically examined in 51 cases of adenoid cystic carcinoma (AdCC) and 143 cases of other salivary gland neoplasms. In all 51 AdCCs, En1 was expressed in 30-100% of tumor cells. In eight of nine polymorphous adenocarcinomas (PACs), En1 was expressed in 40-100% of tumor cells. Less than 5% of tumor cells expressed En1 in three of 12 epithelial-myoepithelial carcinomas, one of 17 basal cell adenomas (BCAs), and one of 34 pleomorphic adenomas (PAs). Among 55 other carcinoma cases, 1-30% of tumor cells expressed En1 in three salivary duct carcinomas (SDCs) ex PA. None of the myoepitheliomas and Warthin tumors expressed En1. When the cut-off value of the percentage of En1-expressing cells was set to 25%, all 51 AdCCs, eight of nine PACs and one SDC ex PA were En1-positive and the others were En1-negative. En1 is expressed consistently in AdCCs, frequently in PACs, but rarely in other salivary gland neoplasms. En1 is a possible diagnostic marker for AdCC and PAC in the histopathology of salivary gland neoplasms., (© 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.)
- Published
- 2021
- Full Text
- View/download PDF
32. Prognostic factors in mucoepidermoid carcinoma of the minor salivary glands: A single-center retrospective study.
- Author
-
Terauchi M, Michi Y, Hirai H, Sugiyama K, Wada A, Harada H, and Yoda T
- Subjects
- Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Prognosis, Retrospective Studies, Salivary Glands, Minor, Carcinoma, Mucoepidermoid surgery, Salivary Gland Neoplasms surgery
- Abstract
Objective: The objective of this study was to investigate the prognostic effects of clinical and histologic findings in patients with mucoepidermoid carcinoma (MEC) of minor salivary glands., Study Design: This retrospective clinical review included 63 patients (30 males, mean age 52.8 years) with minor salivary gland MEC treated at our hospital from 1994 to 2019. Overall survival (OS) or disease-free survival was determined using the Kaplan-Meier limit method. Correlations between different factors and survival rates were assessed using chi-square tests., Results: The 10-year OS rate was 91.2%. Low- or intermediate-grade MEC had a good prognosis regardless of the surgical margin, whereas high-grade MEC had a poor 10-year OS rate (64.2%). Ten patients developed recurrence or metastasis after primary surgical resection, of whom 6 were diagnosed with a high-grade tumor. The most frequently affected site was the palate, whereas the mandibular gingiva was the most commonly affected site during recurrence. Of 4 patients who received chemotherapy and/or radiotherapy postsurgery, 2 had local recurrence and/or neck lymph node metastasis and 1 died from MEC., Conclusion: Patients with low- or intermediate-grade MEC exhibited satisfactory survival after surgery. In patients with high-grade tumors, it has been suggested that survival rates are poor and do not improve following adjuvant therapy., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
33. Primordial odontogenic tumor occurred in the maxilla with unique calcifications and its crucial points for differential diagnosis.
- Author
-
Kayamori K, Tsuchiya M, Michi Y, Kuribayashi A, Mikami T, Sakamoto K, Yoda T, and Ikeda T
- Subjects
- Child, Humans, Male, Maxilla pathology, Neoplasm Recurrence, Local, Diagnosis, Differential, Odontogenic Cyst, Calcifying diagnosis, Odontogenic Cyst, Calcifying pathology, Odontogenic Tumors diagnosis, Odontogenic Tumors pathology
- Abstract
Primordial odontogenic tumor (POT) is a newly classified, mixed epithelial and mesenchymal odontogenic tumor, with only 17 reported cases to date. Herein, we report a case of POT that occurred in the right maxilla of a 10-year-old boy and reveal unique features in comparison with those previously reported. Radiologically, the lesion presented as a well-defined, unilocular radiolucency with notable radiopaque foci on the periphery. Microscopically, the tumor was mainly composed of dental papilla-like myxoid fibrous connective tissue, largely surrounded by non-keratinized squamous epithelium with numerous calcified particles, and partly enclosed by inner enamel epithelium-like columnar cells and enamel organ-like structures accompanied with cuboidal and/or stellate reticulum-like cells. Immunohistochemically, the epithelium tested positive for cytokeratin 14 and 19. Moreover, amelogenin and ameloblastin, matrix proteins relating to enamel formation, were positive in the covering epithelium. The tumor was enucleated as a whole, and no recurrence was recorded thereafter. Although the presence of numerous calcified particles was unique, we diagnosed this lesion as POT based on the above-described features. Furthermore, we emphasize the importance of the differential diagnosis of POT and other odontogenic tumors that resemble corresponding tooth germ components., (© 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.)
- Published
- 2021
- Full Text
- View/download PDF
34. Secretory carcinoma around Stensen's duct misdiagnosed as salivary duct cyst.
- Author
-
Shibata E, Morita KI, Kayamori K, Maruiwa M, Michi Y, Sato Y, Takeuchi K, Ikeda T, Harada H, and Yoda T
- Abstract
Secretory carcinoma (SC) of the salivary gland was identified in 2010, and it is characterized by a specific ETV6 gene arrangement. The most common primary site for SC is the parotid gland; however, SC around the Stensen's duct is rare. Here we describe a rare case of a SC around the Stensen's duct that was initially misdiagnosed as a salivary duct cyst. A 59-year-old woman presented with a mass in the region of the left parotid papilla. Magnetic resonance imaging (MRI) revealed a well-circumscribed lesion and enhancement with a rim and an inner wall-like part that appeared in the late phase. Based on the initial clinical and imaging findings, a salivary duct cyst of the parotid gland was diagnosed. However, the lesion was histopathologically diagnosed as a SC based on immunohistochemical findings. The tumor cells showed diffuse positive staining for AE1/AE3, vimentin, and mammaglobin and focal positive staining for S-100 protein, SOX-10, and DOG-1. Fluorescence in-situ hybridization revealed ETV6 gene rearrangement in the tumor. In cases of cystic lesions around the Stensen's duct, clinicians should bear in mind that the possibility that they could be minor salivary gland cancers, such as SC., Competing Interests: None., (IJCEP Copyright © 2020.)
- Published
- 2020
35. Comparison of 50- and 66-Gy total irradiation doses for postoperative cervical treatment of patients with oral squamous cell carcinoma.
- Author
-
Hirai H, Ohsako T, Kugimoto T, Tomioka H, Michi Y, Kayamori K, Yoda T, Miura M, Yoshimura R, and Harada H
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell mortality, Female, Humans, Male, Middle Aged, Mouth Neoplasms mortality, Retrospective Studies, Survival Analysis, Carcinoma, Squamous Cell radiotherapy, Cranial Irradiation methods, Mouth Neoplasms radiotherapy
- Abstract
Objectives: In patients with advanced oral squamous cell carcinoma (OSCC), surgical treatment is often administered in combination with radiotherapy-based postoperative adjuvant therapy. The aim of the present study was to determine the most appropriate dose by comparing patient outcomes between doses of 50- and 66-Gy for postoperative cervical irradiation., Materials and Methods: This retrospective study included patients who underwent postoperative cervical irradiation following neck dissection for OSCC with lymph nodes metastases, and their primary lesions were controlled. They were divided into the 50- and 66-Gy irradiation groups and were examined for sex, age, primary lesion site, tumor/node/metastasis stage, initial treatment for primary cancer, neck dissection procedure, number of metastatic lymph nodes, presence or absence of extranodal extension (ENE), concomitant anticancer agents, and therapeutic outcomes., Results: A total of 78 patients met the clinical criteria for study enrollment. The 50- and 66-Gy postoperative cervical irradiation groups included 40 and 38 patients, with neck dissection performed at 45 and 38 sites, respectively. Cervical control rate was 97.5% and 97.3% in the 50- and 66-Gy irradiation groups (p = 0.74). The cumulative disease-specific 5-year survival rate was 85.6% and 88.3%, respectively, with no significant difference (p = 0.64)., Conclusion: The findings of our study indicate that the irradiation dose of 50 Gy is appropriate for postoperative cervical irradiation in patients with OSCC., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
36. Genetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma.
- Author
-
Yukimori A, Tsuchiya M, Wada A, Michi Y, Kayamori K, Sakamoto K, and Ikeda T
- Subjects
- Adult, Aged, Ameloblastoma pathology, Carcinoma, Squamous Cell pathology, Humans, Jaw Neoplasms pathology, Male, Mouth Neoplasms genetics, Mouth Neoplasms pathology, Mutation, Odontogenic Tumors pathology, Ameloblastoma genetics, Carcinoma, Squamous Cell genetics, Jaw Neoplasms genetics, Odontogenic Tumors genetics
- Abstract
Background: Primary intraosseous carcinoma (PIOC), NOS is an odontogenic carcinoma with unknown etiology. Its diagnosis may be used when central jaw carcinoma cannot be categorized as any other type of carcinoma. Further information on this extremely rare tumor is needed to improve our understanding and evaluate the classification of odontogenic carcinomas., Case Presentation: We herein presented two patients with PIOC, NOS with different clinical and histopathological features and analyzed gene mutations in these patients using next-generation sequencing (NGS). The typical PIOC, NOS case had many histopathological similarities to oral squamous cell carcinoma (OSCC), including the missense point mutations of TP53 Glu285Val, KDR Gln472His, and APC Pro1433Leu, which are similar to those in other cancers; however, no mutations were detected in the other patient with an atypical presentation of PIOC, NOS, which was derived from a precursor cystic lesion with similarities to both ameloblastic carcinoma and OSCC., Conclusions: Genetic analysis suggested that these two PIOC, NOS cases have different features and can be subcategorized.
- Published
- 2020
- Full Text
- View/download PDF
37. Management of retropharyngeal lymph node metastasis in oral cancer.
- Author
-
Oikawa Y, Michi Y, Tsushima F, Tomioka H, Mochizuki Y, Kugimoto T, Osako T, Nojima H, Yokokawa M, Kashima Y, and Harada H
- Subjects
- Adult, Aged, Female, Humans, Lymph Nodes pathology, Male, Middle Aged, Mouth Neoplasms pathology, Prognosis, Lymphatic Metastasis pathology, Mouth Neoplasms complications
- Abstract
Objectives: Retropharyngeal lymph node (RPLN) metastasis is extremely rare, and prognosis is significantly poor in oral cancer. We retrospectively examined the management of RPLN metastases in oral cancer., Materials and Methods: A total of 1247 patients with oral cancer were treated at our department from January 2002 and December 2016. Among these patients, 374 (30%) had histologically positive lymph node metastases. Of these, 15 patients (1.2%) were diagnosed with RPLN metastases. We evaluated the diagnostic period, size, recurrence pattern, laterality, treatment, and therapeutic outcomes. The Kaplan-Meier method was used to determine overall survival (OS) among the RPLN metastasis group, cervical lymph node (CLN) metastases group, and treatment methods group for RPLN metastases., Results: One patient had RPLN involvement at the initial treatment, and RPLN involvement in other patients was found subsequently. The mean duration in confirming RPLN metastases was 228 days (range, 50-867 days). Surgical therapy was performed in 5 patients, chemoradiotherapy in 7 patients, and best supported care (BSC) in 3 patients. The cumulative 5-year OS rate for the RPLN metastasis group (n = 15) was 38.1%, compared with the rate of 71.3% for the CLN group (n = 359). Regarding the therapeutic approach for RPLN metastases, OS rates were 80.0% (n = 5) in the surgical therapy group, 28.6% (n = 7) in the chemoradiotherapy group, and 0% (n = 3) in the BSC group., Conclusion: Early detection and surgical treatment of RPLN metastases are associated with increased survival rate in oral cancer., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
38. Metastatic gastric adenocarcinoma of the tongue with initial symptoms of glossodynia.
- Author
-
Mochizuki Y, Harada H, Oyama J, Sakamoto K, Michi Y, Kuroshima T, and Kugimoto T
- Subjects
- Adenocarcinoma complications, Adenocarcinoma drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Female, Fluorouracil therapeutic use, Gastric Mucosa drug effects, Glossalgia complications, Glossalgia drug therapy, Humans, Irinotecan therapeutic use, Leucovorin therapeutic use, Middle Aged, Oxaliplatin therapeutic use, Prognosis, Stomach Neoplasms complications, Stomach Neoplasms drug therapy, Adenocarcinoma secondary, Gastric Mucosa pathology, Glossalgia pathology, Stomach Neoplasms pathology
- Abstract
A 60-year-old woman presented to our department with severe tongue pain. On initial examination, the mucosal surface of the tongue was intact but a hard submucosal mass on the dorsum of the tongue was detected on palpation. Magnetic resonance imaging demonstrated an ill-defined tumor in the intrinsic tongue muscles. Sequential whole-body positron emission tomography/computed tomography revealed a tumor of the pancreas apart from the tongue lesion, and upper gastrointestinal endoscopy revealed gastric mucosa ulceration. On biopsy, the tongue lesion was confirmed to be metastatic gastric adenocarcinoma, and the gastric ulcer was simultaneously diagnosed as poorly differentiated gastric adenocarcinoma. The definitive diagnosis was thus gastric adenocarcinoma and synchronous pancreatic cancer, with gastric carcinoma metastases to the tongue. We administered FOLFIRINOX treatment for pancreatic cancer and FLTAX treatment for gastric cancer. Because of difficulty with oral intake due to the growth of the tongue lesion, we administered palliative radiation therapy at a dose of 30 Gy in 10 fractions following which the patient was able to resume oral intake and was satisfied with this outcome. She died 8 months after her first visit to our department., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
39. Glucose metabolism changes during the development and progression of oral tongue squamous cell carcinomas.
- Author
-
Nakazato K, Mogushi K, Kayamori K, Tsuchiya M, Takahashi KI, Sumino J, Michi Y, Yoda T, and Uzawa N
- Abstract
Previous studies have revealed several genes involved in the carcinogenesis of oral cancer. However, the detailed mechanisms underlying this process are poorly understood. Previously, we established a database cataloging the transcriptional progression profile of oral carcinogenesis and identified several candidate genes with continuously increasing or decreasing expression, which specifically promote the transition of oral premalignant lesions to invasive carcinomas. In this study, using our microarray database, we attempted to determine significant genes that may contribute to metabolic alterations during oral carcinogenesis. After performing a literature survey, we focused on 15 candidate genes associated with glucose metabolism changes, particularly the tri-carboxylic acid cycle, and investigated the mRNA-expression status of these genes with our database. Only the solute carrier family 2 member 1 gene (also known as GLUT1), showed significantly increased mRNA expression during oral tumorigenesis. Immunohistochemical analysis confirmed that GLUT1 protein expression significantly increased during oral carcinogenesis. In addition, tumors with high expression of this protein significantly correlated with nodal status (P=0.002). Kaplan-Meier survival curves clearly demonstrated the adverse impact of high GLUT1 protein expression on disease-free survival (P=0.004). GLUT1 mRNA and protein expression increased in the order of normal mucosal tissues, epithelial dysplastic lesions and invasive carcinomas. Therefore, metabolic alterations, especially in glucose metabolism, occurred at the very early stage of development of oral malignancies. In addition, GLUT1 played a significant role in oral cancer, acquiring a malignant phenotype.
- Published
- 2019
- Full Text
- View/download PDF
40. The glomus tumor resorbed bone and teeth in the mandible: a case report.
- Author
-
Kurohara K, Michi Y, Yukimori A, and Yamaguchi S
- Subjects
- Adult, Biopsy, Needle, Follow-Up Studies, Glomus Tumor pathology, Humans, Immunohistochemistry, Male, Mandibular Neoplasms pathology, Neoplasm Recurrence, Local surgery, Radiography, Panoramic methods, Rare Diseases, Reoperation methods, Risk Assessment, Treatment Outcome, Glomus Tumor diagnostic imaging, Glomus Tumor surgery, Mandibular Neoplasms diagnostic imaging, Mandibular Neoplasms surgery, Neoplasm Recurrence, Local pathology, Oral Surgical Procedures methods
- Abstract
Background: A glomus tumor is a rare neoplasm usually found in the dermis or subcutaneous tissue of the extremities. It is rare for the glomus tumor to occur on the head and face. Only 26 glomus tumors of the oral region and affected bone have been reported in the English-language literature (Table 1). We report a case of a glomus tumor at the mandible. As a new point, the glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible., Case Presentation: The patient was a 44-year-old Japanese man who complained swelling of the right mandible. Radiographic examination showed a multilocular radiolucency area in the left mandible. Radiographic findings on our case resembled those of a common benign tumor. The lesion occupied to the premolar and molar area and revealed that the tumor resorbed the roots of the teeth. The lesion was removed surgically with the buccal cortical bone and buccal mucosa in contact with the mass of the tumor. The mass fully excised intraorally under general anesthesia, and the inferior alveolar nerve in contact with the mass was preserved. The specimen was pathologically diagnosed as a glomus tumor. Immunohistochemical staining was positive for vimentin, muscle-specific actin/HHF35, and calponin. A hairline-shaped area of positive staining for type IV collagen surrounding the tumor cells was also observed. In contrast, staining for alpha-SMA, cytokeratin (AE1/AE3), cytokeratin (CAM5.2), CK19, CD31, CD34, CD68, p63, S-100, Factor VIII, and desmin was all negative. The Ki-67 labeling index was almost 1%. A recurrent tumor was again detected in the site below the primary tumor at an 8-year follow-up, and it was surgically removed. The patient has had no symptoms of recurrence in 2 years after the second operation., Conclusion: The glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible. The immunohistochemical features of the tumor were consistent with those described in previous reports. It is important to completely remove the Glomus tumor.
- Published
- 2018
- Full Text
- View/download PDF
41. Detection of Second Primary Malignancies of the Esophagus and Hypophraynx in Oral Squamous Cell Carcinoma Patients.
- Author
-
Matsui T, Okada T, Kawada K, Okuda M, Ogo T, Nakajima Y, Kume Y, Ryotokuji T, Hoshino A, Tokairin Y, Michi Y, Harada H, Nakajima Y, and Kawano T
- Abstract
Objective: To assess the usefulness of modified esophagogastroduodenoscopy (EGD) for the detection of second primary malignancies of the esophagus or hypopharynx in patients with oral squamous cell carcinoma and determine the association between the oral lesion subsite and esophageal or hypopharyngeal lesion occurrence., Study Design: Retrospective review., Methods: In total, 166 patients with oral squamous cell carcinoma without any established symptoms of esophageal or hypopharyngeal squamous cell carcinoma underwent modified EGD based on the Valsalva maneuver and U-turn method, image-enhanced endoscopy, and chromoendoscopy using Lugol's iodine for diagnosis. All suspected lesions were biopsied to determine the clinical stages and duplication rates. Odds ratios for the occurrence of duplicate lesions according to the oral lesion subsite were determined., Results: In total, 37 esophageal and 16 hypopharyngeal lesions were detected. According to the Union for International Cancer Control/American Joint Committee on Cancer classification (2009), 75.7% and 5.4% esophageal lesions were classified as stage IA and IB, respectively, and 50% and 18.8% hypopharyngeal lesions as stage II and stage I, respectively. Approximately 59.1% and 50% esophageal and hypopharyngeal lesions, respectively, were successfully treated by endoscopic resection. Oral lesions involving the floor of the mouth were more frequently accompanied by second primary malignancies of the esophagus or hypopharynx., Conclusions: Modified EGD is an effective noninvasive technique for early diagnosis and treatment of second primary malignancies of the esophagus and hypopharynx in patients with oral squamous cell carcinoma. In particular, patients with floor of the mouth lesions need close monitoring for hypopharyngeal and esophageal lesions., Level of Evidence: 3b.
- Published
- 2018
- Full Text
- View/download PDF
42. Does a Vascularized Fibula Free Bone Grafted Immediately After Hemimandibulectomy in a Child Grow or Relapse During Adolescence?
- Author
-
Okuyama K, Yamashiro M, Kaida A, Kawamata A, Mizutani M, Michi Y, Uzawa N, Yano T, Tohyama R, and Yamaguchi S
- Subjects
- Adolescent, Esthetics, Dental, Fibula growth & development, Follow-Up Studies, Humans, Imaging, Three-Dimensional, Male, Mandibular Neoplasms diagnostic imaging, Models, Dental, Odontoma diagnostic imaging, Osseointegration physiology, Postoperative Complications diagnostic imaging, Tomography, X-Ray Computed, Bone Transplantation methods, Fibula blood supply, Fibula transplantation, Mandibular Neoplasms surgery, Mandibular Osteotomy, Mandibular Reconstruction methods, Odontoma surgery
- Abstract
For young growing children before the end of skeletal maturity, the growth activity of the grafted bone after hemimandibulectomy is not well-known. After an adolescence, such a patient may have facial deformity because the anterior growth point of the mandible is in the condylar neck. A 13-year-old boy was performed hemimandibulectomy with immediate mandibular reconstruction by fibula free flap (FFF) because of a huge ameloblastic fibroma. The authors evaluated the length of FFF on the images of computed tomography (CT) at 5 and 60 months after the operation and compared them by calculating growth rates. Five years after surgery, his facial appearance was symmetry and mandibular function was satisfaction. Although the mandibular bone in the contralateral side grew during 5-year follow-up, the vascularized FFF grafted in the child patient did not significantly grow. Moreover, spontaneous regeneration (SR) and the gradual osteosclerosis were confirmed on the left distal edge of the FFF on the CT imaging. The arrival of SR at the left distal edge of the FFF was considered a part of the reason to compensate the unchanging growth rate of the grafted FFF and contribute for the postoperative good functional and esthetic results.
- Published
- 2018
- Full Text
- View/download PDF
43. Clinical usefulness of 2-deoxy-2-[18F] fluoro-d-glucose-positron emission tomography/computed tomography for assessing early oral squamous cell carcinoma (cT1-2N0M0).
- Author
-
Yamaga E, Toriihara A, Nakamura S, Asai S, Fujioka T, Yoshimura R, Michi Y, Harada H, and Tateishi U
- Subjects
- Aged, Carcinoma, Squamous Cell pathology, Female, Humans, Lymphatic Metastasis diagnostic imaging, Lymphatic Metastasis pathology, Male, Middle Aged, Mouth Neoplasms pathology, Multimodal Imaging, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Neoplasms, Multiple Primary diagnostic imaging, Neoplasms, Multiple Primary pathology, Retrospective Studies, Tumor Burden, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell diagnostic imaging, Fluorodeoxyglucose F18 chemistry, Mouth Neoplasms diagnosis, Mouth Neoplasms diagnostic imaging, Positron Emission Tomography Computed Tomography
- Abstract
Background: Positron emission tomography with 2-deoxy-2-[18F] fluoro-d-glucose integrated with computed tomography (FDG-PET/CT) is a useful method to evaluate patients with oral squamous cell carcinoma (OSCC). However, the prognostic significance of FDG-PET/CT for assessing early OSCC remains unclear., Methods: Pretreatment FDG-PET/CT of 205 consecutive patients (125 men, 80 women, mean age 59.7 year old) with early OSCC (cT1-2N0M0) between June 2010 and December 2014 were retrospectively analyzed. FDG avidity in primary lesions was assessed by visual interpretation. Thereafter, maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured in primary lesions. The relationship between each parameter and recurrence free survival (RFS) was assessed using the log-rank test. The performance of FDG-PET/CT for diagnosing metastatic lesions and synchronous cancer was also assessed., Results: During the follow-up period (mean 32.9 months), 43 patients developed recurrences (21.0%). Patients with visually positive FDG uptake in primary lesions showed significantly shorter RFS than the others (63.0 months vs. 52.9 months, P = 0.005). In those patients, greater SUVmax, MTV, and TLG did not significantly predict shorter RFS. The sensitivity and specificity of FDG-PET/CT for cervical nodal metastases detection were 32.3% and 77.6%, respectively. FDG-PET/CT detected eight synchronous cancers (3.9%) and overlooked six synchronous cancers (2.9%)., Conclusions: Although its utility for detecting cervical nodal metastases and synchronous cancers is limited, FDG-PET/CT is a potentially prognostic indicator in early OSCC.
- Published
- 2018
- Full Text
- View/download PDF
44. Potential factors influencing the development of oral tongue squamous cell carcinoma in young mature patients: Lingual position of the mandibular second molar and narrow tongue space.
- Author
-
Kim Y, Okuyama K, Michi Y, Ohyama Y, Uzawa N, and Yamaguchi S
- Abstract
The lingual position of the mandibular second molar and narrow tongue space are associated with oral tongue squamous cell carcinoma (OTSCC) development in young mature patients. The present study aimed to assess the role of the mandibular second molar position and tongue space in young mature patients with OTSCC. The medical records of 21 patients with OTSCC aged <50 years, who had an intact mandibular second molar and had undergone computed tomography (CT) imaging between April 2009 and December 2015 at the Section of Maxillofacial Surgery in Tokyo Medical and Dental University, were retrospectively examined. As controls, 21 sex-matched patients of a similar age to the patients in the OTSCC group, and with a height and weight within 5% of those of the OTSCC group, were collected. The location of the mandibular second molar on the affected side and area of the tongue space were determined using coronal and axial CT images. Mann-Whitney U test analysis revealed that the location of the mandibular second molar and the area of the tongue space differed significantly between young mature patients with OTSCC and the controls. The present study thus revealed that the lingual position of the mandibular second molar and the narrow tongue space may be potential factors influencing OTSCC development in young maturity.
- Published
- 2017
- Full Text
- View/download PDF
45. Clinical Study of 597 Oral Squamous Cell Carcinomas in Our Department - Especially about 318 Tongue Carcinoma.
- Author
-
Mizutani M, Michi Y, Katsuki Y, Ohyama Y, Uzawa N, Myo K, Kawamata A, Sumino J, Miura C, Morita T, Yamashiro M, Amagasa T, and Yamaguchi S
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neoplasm Staging, Tongue Neoplasms diagnosis, Tongue Neoplasms pathology, Tongue Neoplasms therapy, Young Adult, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell therapy, Mouth Neoplasms diagnosis, Mouth Neoplasms pathology, Mouth Neoplasms therapy
- Abstract
This clinico-statistical study includes 597 cases of oral squamous cell carcinoma treated at the Maxillofacial Surgery Section of Tokyo Medical and Dental University between January 2002 and December 2011. There were 373 male and 224 female patients (male to female ratio, 1.7 : 1), and the median age was 67 years. The tongue (53.3%) was the most commonly affected site. The 5-year disease-specific survival rate was 84.8%. Survival rates by clinical stage were as follows : Stage 1, 92.1% (n=195).; Stage , 86.0% (n = 221) ; Stage III, 77.7% (n=65) ; and Stage IV, 73.8% (n =116). Survival rates by primary site were as follows: tongue, 85.4% (n=318) ; lower gingiva, 82.8% (n =114) upper gingiva, 83.7% (n=59) ; buccal mucosa, 89.1% (n 54) ; oral floor, 81.4% (n=49) ; and hard palate, 100% (n=3). According to clinical growth patterns of Stage I / I tongue cancer cases, the 5-year disease-specific survival rate was significantly higher for patients with the exophytic/superficial type (97.3%, n =173) than for those with the endophytic type (77.5%, n=145). Among Stage I/II tongue cancer cases, the corresponding survival rate was significantly higher for patients who had not previously undergone invasive treatments (n=201), such as tooth extraction, compared to those who had previously done so (n=54) (92.7% and 79.7%, respectively). In addition, the incidence of secondary cervical lymph node metastasis was significantly higher in patients who had previously undergone invasive treatments.
- Published
- 2016
46. Clinical study on mandibular fracture after marginal resection of the mandible.
- Author
-
Okuyama K, Michi Y, Mizutani M, Yamashiro M, Kaida A, and Harada K
- Subjects
- Aged, Aged, 80 and over, Female, Gingival Neoplasms pathology, Humans, Jaw, Edentulous, Partially diagnostic imaging, Male, Mandibular Fractures prevention & control, Middle Aged, Neoplasm Grading, Postoperative Complications prevention & control, Radiography, Panoramic, Retrospective Studies, Risk Factors, Gingival Neoplasms surgery, Mandible surgery, Mandibular Fractures etiology, Postoperative Complications etiology
- Abstract
Objectives: Postoperative mandibular fracture (PMF) after marginal resection (MR) of the mandible remains an unresolved issue, and it has been reported that at least 10 mm of postoperative mandibular body height (PMBH) is required to prevent PMF. This study evaluated the clinical, physical, and structural risk factors for PMF in MR patients and determined appropriate preventive measures for PMF., Study Design: This retrospective study included 44 patients with lower gingival carcinoma who underwent MR. PMF occurred in four of these patients. Thirteen associated factors identified from medical records and radiographs were statistically analyzed., Results: Mandibular body height (MBH) preservation ratio originally evaluated as less than 0.3, more than 20 remaining teeth after surgery, and inferior alveolar canal (IAC) exposure were significant risk factors for PMF. Prostheses and number of remaining teeth were also correlated with PMF., Conclusions: The preserved mandibular bone should be reinforced in patients with an MBH preservation ratio of less than 0.3, more than 20 remaining teeth after surgery, and intraoperative IAC exposure. Patients with prostheses are at an increased risk of PMF compared with those without because of stable occlusion and a strong occlusal force. Our novel findings provide useful reference standards for PMF prevention in MR patients., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
47. Primary intraosseous squamous cell carcinoma derived from a maxillary cyst: A case report and literature review.
- Author
-
Morita T, Yamashiro M, Kayamori K, Mizutani M, Nakakuki K, Michi Y, Uzawa N, Izumo T, and Harada K
- Abstract
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant central jaw tumor derived from odontogenic epithelial remnants. PIOSCC predominantly affects the mandible, although both jawbones may be involved. This case report describes a PIOSCC type 2 of the maxilla in a 37-year-old man, treated by partial maxillectomy. Histopathologically, the tumor was diagnosed as PIOSCC derived from an odontogenic cyst. Postoperatively, the patient has been followed up for 53 months, with no recurrence of the disease. We herein describe the clinical details, treatment results and histopathological characteristics of a rare case of PIOSCC derived from a maxillary odontogenic cyst with reference to the relevant literature.
- Published
- 2016
- Full Text
- View/download PDF
48. A case of hemangiopericytoma of the soft palate with articulate disorder and dysphagia.
- Author
-
Michi Y, Suzuki M, Kurohara K, and Harada K
- Subjects
- 12E7 Antigen, Antigens, CD analysis, Antigens, CD34 analysis, Cell Adhesion Molecules analysis, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Tomography, X-Ray Computed, Vimentin analysis, Articulation Disorders etiology, Deglutition Disorders etiology, Hemangiopericytoma complications, Palatal Neoplasms complications, Palate, Soft pathology
- Abstract
We report a case of hemangiopericytoma of the soft palate of 60-year-old patient, who noticed a mass of the soft palate and experienced difficulty in speaking. We found a pediculate, hard, elastic mass measuring 38 mm (cross-sectional diameter). Computed tomography (CT) scans and dynamic magnetic resonance imaging (MRI) confirmed irregularly shaped mass and revealed a heterogeneous internal composition, consistent with vascular tumors. We excised the tumor under general anesthesia. Histopathological diagnosis was based on positive immunoreactivity of CD99 and vimentin and weak, positive staining of CD34. Three and half years following tumor excision, there is no recurrence or metastasis.
- Published
- 2013
- Full Text
- View/download PDF
49. Unusual expression of red fluorescence at M phase induced by anti-microtubule agents in HeLa cells expressing the fluorescent ubiquitination-based cell cycle indicator (Fucci).
- Author
-
Honda-Uezono A, Kaida A, Michi Y, Harada K, Hayashi Y, Hayashi Y, and Miura M
- Subjects
- HeLa Cells, Humans, Luminescent Proteins analysis, Nocodazole pharmacology, Ubiquitin-Protein Ligases metabolism, Cell Division drug effects, Diketopiperazines pharmacology, Fluorescence, Luminescent Proteins biosynthesis, Microtubules drug effects, Mitosis drug effects, Tubulin Modulators pharmacology
- Abstract
Plinabulin (NPI-2358) is a novel microtubule-depolymerizing agent. In HeLa cells, plinabulin arrests the cell-cycle at M phase and subsequently induces mitotic catastrophe. To better understand the effects on this compound on the cell-cycle, we used the fluorescent ubiquitination-based cell cycle indicator (Fucci), which normally enables G1 and S/G2/M cells to emit red and green fluorescence, respectively. When HeLa-Fucci cells were treated with 50 nM plinabulin, cells began to fluoresce both green and red in an unusual pattern; most cells exhibited the new pattern after 24 h of treatment. X-irradiation efficiently induced G2 arrest in plinabulin-treated cells and significantly retarded the emergence of the unusual pattern, suggesting that entering M phase is essential for induction of the pattern. By simultaneously visualizing chromosomes with GFP-histone H2B, we established that the pattern emerges after nuclear envelope breakdown but before metaphase. Pedigree assay revealed a significant relationship between the unusual expression and mitotic catastrophe. Nocodazole, KPU-133 (a more potent derivative of plinabulin), and paclitaxel also exerted similar effects. From these data, we conclude that the unusual pattern may be associated with dysregulation of late M phase-specific E3 ligase activity and mitotic catastrophe following treatment with anti-microtubule agents., (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
50. A neuroendocrine tumor in the maxilla.
- Author
-
Kurohara K, Uzawa N, Michi Y, and Harada K
- Subjects
- Adult, Carcinoid Tumor surgery, Carcinoid Tumor therapy, Chemoradiotherapy, Adjuvant, Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Male, Maxillary Neoplasms surgery, Maxillary Neoplasms therapy, Tomography, X-Ray Computed, Carcinoid Tumor pathology, Maxillary Neoplasms pathology
- Published
- 2012
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.