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3. Management of adult-onset Still's disease: evidence- and consensus-based recommendations by experts

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Arts-assistenten Kinderen, CTI Van Loosdregt, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Child Health, Leavis, Helen L, van Daele, Paul L A, Mulders-Manders, Catharina, Michels, Renée, Rutgers, Abraham, Legger, Elizabeth, Bijl, Marc, Hak, Elisabeth A, Lam-Tse, Wai-Kwan, Bonte-Mineur, Femke, Fretter, Peter, Simon, Anna, van Paassen, Pieter, van der Goes, Marlies, Flendrie, Marcel, Vercoutere, Ward, van Lieshout, Antoine W T, Leek, Arjen, Vastert, Sebastiaan J, Tas, Sander W, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Arts-assistenten Kinderen, CTI Van Loosdregt, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Child Health, Leavis, Helen L, van Daele, Paul L A, Mulders-Manders, Catharina, Michels, Renée, Rutgers, Abraham, Legger, Elizabeth, Bijl, Marc, Hak, Elisabeth A, Lam-Tse, Wai-Kwan, Bonte-Mineur, Femke, Fretter, Peter, Simon, Anna, van Paassen, Pieter, van der Goes, Marlies, Flendrie, Marcel, Vercoutere, Ward, van Lieshout, Antoine W T, Leek, Arjen, Vastert, Sebastiaan J, and Tas, Sander W

Published
2024

4. Management of adult-onset Still's disease:evidence- and consensus-based recommendations by experts

Author

Leavis, Helen L., van Daele, Paul L.A., Mulders-Manders, Catharina, Michels, Renée, Rutgers, Abraham, Legger, Elizabeth, Bijl, Marc, Hak, Elisabeth A., Lam-Tse, Wai Kwan, Bonte-Mineur, Femke, Fretter, Peter, Simon, Anna, van Paassen, Pieter, van der Goes, Marlies C., Flendrie, Marcel, Vercoutere, Ward, van Lieshout, Antoine W.T., Leek, Arjen, Vastert, Sebastiaan J., Tas, Sander W., Leavis, Helen L., van Daele, Paul L.A., Mulders-Manders, Catharina, Michels, Renée, Rutgers, Abraham, Legger, Elizabeth, Bijl, Marc, Hak, Elisabeth A., Lam-Tse, Wai Kwan, Bonte-Mineur, Femke, Fretter, Peter, Simon, Anna, van Paassen, Pieter, van der Goes, Marlies C., Flendrie, Marcel, Vercoutere, Ward, van Lieshout, Antoine W.T., Leek, Arjen, Vastert, Sebastiaan J., and Tas, Sander W.

Abstract

Objectives: Adult-onset Still's disease (AOSD) is a rare condition characterized by fevers, rash, and arthralgia/arthritis; most doctors treating AOSD in the Netherlands treat <5 patients per year. Currently, there is no internationally accepted treatment guideline for AOSD. The objectives of this study were to conduct a Delphi panel aimed at reaching consensus about diagnostic and treatment strategies for patients with AOSD and to use the outcomes as a basis for a treatment algorithm. Methods: The Delphi panel brought together 18 AOSD experts: rheumatologists, internists and paediatricians. The Delphi process consisted of three rounds. In the first two rounds, online lists of questions and statements were completed. In the third round, final statements were discussed during a virtual meeting and a final vote took place. Consensus threshold was set at 80%. Two targeted literature searches were performed identifying the level of evidence of the consensus-based statements. Results: Consensus was reached on 29 statements, including statements related to diagnosis and diagnostic tests, definition of response and remission, the therapy, the use of methotrexate and tapering of treatment. The panel consented on reduction of the use of glucocorticoids to avoid side effects, and preferred the use of biologics over conventional treatment. The role of IL-1 and IL-6 blocking agents was considered important in the treatment of AOSD. Conclusion: In this Delphi panel, a high level of consensus was achieved on recommendations for diagnosis and therapy of AOSD that can serve as a basis for a treatment guideline.

Published
2024

6. Management of adult-onset Still's disease: evidence- and consensus-based recommendations by experts.

Author

Leavis, Helen L, Daele, Paul L A van, Mulders-Manders, Catharina, Michels, Renée, Rutgers, Abraham, Legger, Elizabeth, Bijl, Marc, Hak, Elisabeth A, Lam-Tse, Wai-Kwan, Bonte-Mineur, Femke, Fretter, Peter, Simon, Anna, Paassen, Pieter van, Goes, Marlies C van der, Flendrie, Marcel, Vercoutere, Ward, Lieshout, Antoine W T van, Leek, Arjen, Vastert, Sebastiaan J, and Tas, Sander W

Subjects
RHEUMATOID arthritis diagnosis, BIOTHERAPY, RHEUMATOID arthritis treatment, CONSENSUS (Social sciences), WORLD Wide Web, RESEARCH funding, QUESTIONNAIRES, METHOTREXATE, TREATMENT effectiveness, DESCRIPTIVE statistics, EVIDENCE-based medicine, DELPHI method, RHEUMATOLOGISTS, GLUCOCORTICOIDS, EVALUATION
Abstract

Objectives Adult-onset Still's disease (AOSD) is a rare condition characterized by fevers, rash, and arthralgia/arthritis; most doctors treating AOSD in the Netherlands treat <5 patients per year. Currently, there is no internationally accepted treatment guideline for AOSD. The objectives of this study were to conduct a Delphi panel aimed at reaching consensus about diagnostic and treatment strategies for patients with AOSD and to use the outcomes as a basis for a treatment algorithm. Methods The Delphi panel brought together 18 AOSD experts: rheumatologists, internists and paediatricians. The Delphi process consisted of three rounds. In the first two rounds, online lists of questions and statements were completed. In the third round, final statements were discussed during a virtual meeting and a final vote took place. Consensus threshold was set at 80%. Two targeted literature searches were performed identifying the level of evidence of the consensus-based statements. Results Consensus was reached on 29 statements, including statements related to diagnosis and diagnostic tests, definition of response and remission, the therapy, the use of methotrexate and tapering of treatment. The panel consented on reduction of the use of glucocorticoids to avoid side effects, and preferred the use of biologics over conventional treatment. The role of IL-1 and IL-6 blocking agents was considered important in the treatment of AOSD. Conclusion In this Delphi panel, a high level of consensus was achieved on recommendations for diagnosis and therapy of AOSD that can serve as a basis for a treatment guideline. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Management of adult-onset Still's disease: evidence- and consensus-based recommendations by experts

Author

Leavis, Helen L, primary, van Daele, Paul L A, additional, Mulders-Manders, Catharina, additional, Michels, Renée, additional, Rutgers, Abraham, additional, Legger, Elizabeth, additional, Bijl, Marc, additional, Hak, Elisabeth A, additional, Lam-Tse, Wai-Kwan, additional, Bonte-Mineur, Femke, additional, Fretter, Peter, additional, Simon, Anna, additional, van Paassen, Pieter, additional, van der Goes, Marlies, additional, Flendrie, Marcel, additional, Vercoutere, Ward, additional, van Lieshout, Antoine W T, additional, Leek, Arjen, additional, Vastert, Sebastiaan J, additional, and Tas, Sander W, additional

Published
2023
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11. Additional file 1 of Concerns, quality of life, access to care and productivity of the general population during the first 8 weeks of the coronavirus lockdown in Belgium and the Netherlands

Author

Ballegooijen, Hanne Van, Goossens, Lucas, Bruin, Ralph H., Michels, Renée, and Krol, Marieke

Abstract

Additional file 1: Supplemental Table 1. Stress and concerns financials during the first 8 weeks of the national COVID-19 measures in Belgium. Supplemental Table 2. Stress and concerns about financials during the during the first 8 weeks of the national COVID-19 measures in the Netherlands. Supplemental Table 3. Concerns about care during first 8 weeks of the national COVID-19 measures in Belgium. Supplemental Table 4. Concerns about care during the first 8 weeks of the national COVID-19 national measures in the Netherlands. Supplemental Table 5. Self-perceived health and quality of life before and during the national COVID-19 measures stratified by age and COVID-19 in Belgium. Supplemental Table 6. Self-perceived health and quality of life before and during the national COVID-19 measures stratified by age and COVID-19 in the Netherlands. Supplemental Table 7. Cancelled or postponed healthcare appointments. Supplemental Table 8. Productivity losses in respondents in paid profession Belgium. Supplemental Table 9. Productivity losses among respondents in paid profession Netherlands.

Published
2021
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14. A Delphi panel on treatment of high disease activity relapsing remitting multiple sclerosis in the Netherlands

Author

Michels, Renée E, Peters, Michel L, Schiffers, Krijn MH, Bouma, Paul A, Hengstman, Gerald ID, van Munster, Caspar EP, Zeinstra, Esther, Voer, Gert De, and Krol, Marieke

Abstract

Aim:To gain insight into current treatment and barriers to optimal treatment for high disease activity relapsing remitting multiple sclerosis (MS) in the Netherlands. Materials & methods:A two-round Delphi panel using an online questionnaire was conducted. Seven MS neurologists from diverse locations in the Netherlands were invited to participate. Result:Out of the seven MS neurologists, five completed both questionnaire rounds. Conclusion:Effectiveness and side effects along with patient’s lesion load were the most important factors for choosing a disease modifying therapy (DMTs). Respondents felt restricted to optimally treat their patients due to reimbursement restrictions for certain disease modifying therapies, although agreed that satisfactory treatment options are currently available. The answers show consensus between the participating MS neurologists with high certainty of answers.

Published
2020
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