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7 results on '"Michele W. Teng"'

1. Supplementary Figure 5 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Michael H. Kershaw, Phillip K. Darcy, Paul Neeson, Nicholas P. Restifo, Steven A. Rosenberg, Zhiya Yu, Aesha Ali, Michele W. Teng, Mark J. Smyth, Ricky W. Johnstone, Joseph A. Trapani, H. Miles Prince, Sarah Ellis, David C. Tscharke, Sherly Mardiana, Jennifer A. Westwood, Paul A. Beavis, Alexander J. Davenport, Bianca von Scheidt, and Clare Y. Slaney

Abstract

CARaMEL T cells persist in long term surviving mice.

Published
2023

2. Supplementary Figure 3 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Michael H. Kershaw, Phillip K. Darcy, Paul Neeson, Nicholas P. Restifo, Steven A. Rosenberg, Zhiya Yu, Aesha Ali, Michele W. Teng, Mark J. Smyth, Ricky W. Johnstone, Joseph A. Trapani, H. Miles Prince, Sarah Ellis, David C. Tscharke, Sherly Mardiana, Jennifer A. Westwood, Paul A. Beavis, Alexander J. Davenport, Bianca von Scheidt, and Clare Y. Slaney

Abstract

CAR T cells lacking the pMEL TCR are less effective than CARaMEL T cells at inhibiting tumor growth.

Published
2023

3. Supplementary Figure 1 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Michael H. Kershaw, Phillip K. Darcy, Paul Neeson, Nicholas P. Restifo, Steven A. Rosenberg, Zhiya Yu, Aesha Ali, Michele W. Teng, Mark J. Smyth, Ricky W. Johnstone, Joseph A. Trapani, H. Miles Prince, Sarah Ellis, David C. Tscharke, Sherly Mardiana, Jennifer A. Westwood, Paul A. Beavis, Alexander J. Davenport, Bianca von Scheidt, and Clare Y. Slaney

Abstract

Dual-specific T cells respond against both gp100 and Her2.

Published
2023

4. Supplementary Figure 2 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Michael H. Kershaw, Phillip K. Darcy, Paul Neeson, Nicholas P. Restifo, Steven A. Rosenberg, Zhiya Yu, Aesha Ali, Michele W. Teng, Mark J. Smyth, Ricky W. Johnstone, Joseph A. Trapani, H. Miles Prince, Sarah Ellis, David C. Tscharke, Sherly Mardiana, Jennifer A. Westwood, Paul A. Beavis, Alexander J. Davenport, Bianca von Scheidt, and Clare Y. Slaney

Abstract

High dose IL-2 enables durable tumor regression and proliferation of T cells.

Published
2023

5. Supplementary Figure 6 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Michael H. Kershaw, Phillip K. Darcy, Paul Neeson, Nicholas P. Restifo, Steven A. Rosenberg, Zhiya Yu, Aesha Ali, Michele W. Teng, Mark J. Smyth, Ricky W. Johnstone, Joseph A. Trapani, H. Miles Prince, Sarah Ellis, David C. Tscharke, Sherly Mardiana, Jennifer A. Westwood, Paul A. Beavis, Alexander J. Davenport, Bianca von Scheidt, and Clare Y. Slaney

Abstract

Cytokines present in serum of ACTIV-treated mice.

Published
2023

6. Data from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Michael H. Kershaw, Phillip K. Darcy, Paul Neeson, Nicholas P. Restifo, Steven A. Rosenberg, Zhiya Yu, Aesha Ali, Michele W. Teng, Mark J. Smyth, Ricky W. Johnstone, Joseph A. Trapani, H. Miles Prince, Sarah Ellis, David C. Tscharke, Sherly Mardiana, Jennifer A. Westwood, Paul A. Beavis, Alexander J. Davenport, Bianca von Scheidt, and Clare Y. Slaney

Abstract

Purpose: While adoptive transfer of T cells bearing a chimeric antigen receptor (CAR) can eliminate substantial burdens of some leukemias, the ultimate challenge remains the eradication of large solid tumors for most cancers. We aimed to develop an immunotherapy approach effective against large tumors in an immunocompetent, self-antigen preclinical mouse model.Experimental Design: In this study, we generated dual-specific T cells expressing both a CAR specific for Her2 and a TCR specific for the melanocyte protein (gp100). We used a regimen of adoptive cell transfer incorporating vaccination (ACTIV), with recombinant vaccinia virus expressing gp100, to treat a range of tumors including orthotopic breast tumors and large liver tumors.Results: ACTIV therapy induced durable complete remission of a variety of Her2+ tumors, some in excess of 150 mm2, in immunocompetent mice expressing Her2 in normal tissues, including the breast and brain. Vaccinia virus induced extensive proliferation of T cells, leading to massive infiltration of T cells into tumors. Durable tumor responses required the chemokine receptor CXCR3 and exogenous IL2, but were independent of IFNγ. Mice were resistant to tumor rechallenge, indicating immune memory involving epitope spreading. Evidence of limited neurologic toxicity was observed, associated with infiltration of cerebellum by T cells, but was only transient.Conclusions: This study supports a view that it is possible to design a highly effective combination immunotherapy for solid cancers, with acceptable transient toxicity, even when the target antigen is also expressed in vital tissues. Clin Cancer Res; 23(10); 2478–90. ©2016 AACR.

Published
2023

7. Supplementary Figure 4 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Author

Michael H. Kershaw, Phillip K. Darcy, Paul Neeson, Nicholas P. Restifo, Steven A. Rosenberg, Zhiya Yu, Aesha Ali, Michele W. Teng, Mark J. Smyth, Ricky W. Johnstone, Joseph A. Trapani, H. Miles Prince, Sarah Ellis, David C. Tscharke, Sherly Mardiana, Jennifer A. Westwood, Paul A. Beavis, Alexander J. Davenport, Bianca von Scheidt, and Clare Y. Slaney

Abstract

ACTIV therapy induces cytokine secretion and apoptosis of tumor cells.

Published
2023

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