1. Trypanocidal and leishmanicidal properties of substitution-containing chalcones
- Author
-
Andrea T. Rodrigues, Edmundo C. Grisard, Michel Guzela, João B. Calixto, Adair R.S. Santos, Fabiane Lunardi, Iriane Eger-Mangrich, Mário Steindel, Rogério Corrêa, and Jamil Assreuy
- Subjects
Chalcone ,Stereochemistry ,medicine.drug_class ,Trypanosoma cruzi ,Biology ,Leishmania braziliensis ,Structure-Activity Relationship ,chemistry.chemical_compound ,Amphotericin B ,parasitic diseases ,medicine ,Animals ,Structure–activity relationship ,Pharmacology (medical) ,Trypanocidal agent ,Pharmacology ,Dose-Response Relationship, Drug ,Kinetoplastida ,Biological activity ,biology.organism_classification ,Infectious Diseases ,chemistry ,Nitroimidazoles ,Susceptibility ,Antiprotozoal - Abstract
Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth ofLeishmania braziliensisandTrypanosoma cruziwith no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.