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5 results on '"Micheau, Pascale"'

1. Clinical course and cost assessment of infants with a first episode of acute bronchiolitis presenting to the emergency department: Data from the GUERANDE clinical trial

Author

Butel, Thibault, primary, Angoulvant, François, additional, Filipovic‐Pierucci, Antoine, additional, Milcent, Karen, additional, Teglas, Jean‐Paul, additional, Bellêttre, Xavier, additional, Claudet, Isabelle, additional, Gras‐le Guen, Christèle, additional, de Pontual, Loïc, additional, Minodier, Philippe, additional, Dubos, François, additional, Brouard, Jacques, additional, Soussan‐Banini, Valérie, additional, Degas‐Bussiere, Vanessa, additional, Gatin, Amélie, additional, Schweitzer, Cyril, additional, Epaud, Ralph, additional, Ryckewaert, Amélie, additional, Cros, Pierrick, additional, Marot, Yves, additional, Flahaut, Philippe, additional, Saunier, Pascal, additional, Babe, Philippe, additional, Patteau, Géraldine, additional, Delebarre, Mathilde, additional, Titomanlio, Luigi, additional, Vrignaud, Bénédicte, additional, Trieu, Thanh‐Van, additional, Tahir, Abdelilah, additional, Regnard, Delphine, additional, Micheau, Pascale, additional, Charara, Oussama, additional, Henry, Simon, additional, Ploin, Dominique, additional, Panjo, Henri, additional, Vabret, Astrid, additional, Bouyer, Jean, additional, Durand‐Zaleski, Isabelle, additional, and Gajdos, Vincent, additional

Published
2021
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2. Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis

Author

Angoulvant, François, Bellêttre, Xavier, Milcent, Karen, Teglas, Jean-Paul, Claudet, Isabelle, Le Guen, Christèle, de Pontual, Loïc, Minodier, Philippe, Dubos, Francois, Brouard, Jacques, Soussan-Banini, Valérie, Degas-Bussiere, Vanessa, Gatin, Amélie, Schweitzer, Cyril, Epaud, Ralph, Ryckewaert, Amélie, Cros, Pierrick, Marot, Yves, Flahaut, Philippe, Saunier, Pascal, Babe, Philippe, Patteau, Géraldine, Delebarre, Mathilde, Titomanlio, Luigi, Vrignaud, Bénédicte, Trieu, Thanh-Van, Tahir, Abdelilah, Regnard, Delphine, Micheau, Pascale, Charara, Oussama, Henry, Simon, Ploin, Dominique, Panjo, Henri, Vabret, Astrid, Bouyer, Jean, Gajdos, Vincent, Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital des Enfants, CHU Toulouse [Toulouse], Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Marseille, Hôpital Jeanne de Flandre [Lille], Service de Pédiatrie Médicale [Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital Ambroise Paré [AP-HP], Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), Centre Hospitalier Intercommunal de Créteil (CHIC), CHU Pontchaillou [Rennes], Hôpital Morvan - CHRU de Brest (CHU - BREST ), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Rouen, Normandie Université (NU), Hôpital Delafontaine, Centre Hospitalier de Saint-Denis [Ile-de-France], Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Necker - Enfants Malades [AP-HP], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Robert Debré, Hôpital Jean Verdier [AP-HP], CHU Limoges, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Centre Hospitalier de Versailles André Mignot (CHV), Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Service d'urgence et de réanimation pédiatriques [Hôpital Edouard Herriot - HCL], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris]-Université Paris Diderot - Paris 7 (UPD7), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Urgences pédiatriques [CHU Nord Marseille], North University Hospital of Marseille, Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité. (DevAH), Hôpital Intercommunal Créteil, Service de pédiatrie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service Pédiatrique [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-CHU Trousseau [APHP], Santé publique : épidémiologie et qualité des soins-EA 2694 (CERIM), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)

Subjects
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

5. Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial.

Author

Angoulvant F, Bellêttre X, Milcent K, Teglas JP, Claudet I, Le Guen CG, de Pontual L, Minodier P, Dubos F, Brouard J, Soussan-Banini V, Degas-Bussiere V, Gatin A, Schweitzer C, Epaud R, Ryckewaert A, Cros P, Marot Y, Flahaut P, Saunier P, Babe P, Patteau G, Delebarre M, Titomanlio L, Vrignaud B, Trieu TV, Tahir A, Regnard D, Micheau P, Charara O, Henry S, Ploin D, Panjo H, Vabret A, Bouyer J, and Gajdos V

Subjects
Acute Disease, Administration, Inhalation, Double-Blind Method, Emergency Medical Services, Female, Humans, Infant, Infant Health, Male, Severity of Illness Index, Treatment Outcome, Bronchiolitis drug therapy, Bronchodilator Agents administration & dosage, Child, Hospitalized statistics & numerical data, Nebulizers and Vaporizers, Saline Solution, Hypertonic administration & dosage
Abstract

Importance: Acute bronchiolitis is the leading cause of hospitalization among infants. Previous studies, underpowered to examine hospital admission, have found a limited benefit of nebulized hypertonic saline (HS) treatment in the pediatric emergency department (ED)., Objective: To examine whether HS nebulization treatment would decrease the hospital admission rate among infants with a first episode of acute bronchiolitis., Design, Setting, and Participants: The Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis (GUERANDE) study was a multicenter, double-blind randomized clinical trial on 2 parallel groups conducted during 2 bronchiolitis seasons (October through March) from October 15, 2012, through April 15, 2014, at 24 French pediatric EDs. Among the 2445 infants (6 weeks to 12 months of age) assessed for inclusion, 777 with a first episode of acute bronchiolitis with respiratory distress and no chronic medical condition were included., Interventions: Two 20-minute nebulization treatments of 4 mL of HS, 3%, or 4 mL of normal saline (NS), 0.9%, given 20 minutes apart., Main Outcomes and Measures: Hospital admission rate in the 24 hours after enrollment., Results: Of the 777 infants included in the study (median age, 3 months; interquartile range, 2-5 months; 468 [60.2%] male), 385 (49.5%) were randomized to the HS group and 387 (49.8%) to the NS group (5 patients did not receive treatment). By 24 hours, 185 of 385 infants (48.1%) in the HS group were admitted compared with 202 of 387 infants (52.2%) in the NS group. The risk difference for hospitalizations was not significant according to the mixed-effects regression model (adjusted risk difference, -3.2%; 95% CI, -8.7% to 2.2%; P = .25). The mean (SD) Respiratory Distress Assessment Instrument score improvement was greater in the HS group (-3.1 [3.2]) than in the NS group (-2.4 [3.3]) (adjusted difference, -0.7; 95% CI, -1.2 to -0.2; P = .006) and similarly for the Respiratory Assessment Change Score. Mild adverse events, such as worsening of cough, occurred more frequently among children in the HS group (35 of 392 [8.9%]) than among those in the NS group (15 of 384 [3.9%]) (risk difference, 5.0%; 95% CI, 1.6%-8.4%; P = .005), with no serious adverse events., Conclusions and Relevance: Nebulized HS treatment did not significantly reduce the rate of hospital admissions among infants with a first episode of acute moderate to severe bronchiolitis who were admitted to the pediatric ED relative to NS, but mild adverse events were more frequent in the HS group., Trial Registration: clinicaltrials.gov Identifier: NCT01777347.

Published
2017
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