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5. History of Periodontitis Diagnosis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality in Postmenopausal Women

Author

LaMonte, Michael J, Genco, Robert J, Hovey, Kathleen M, Wallace, Robert B, Freudenheim, Jo L, Michaud, Dominique S, Mai, Xiaodan, Tinker, Lesley F, Salazar, Christian R, Andrews, Christopher A, Li, Wenjun, Eaton, Charles B, Martin, Lisa W, and Wactawski‐Wende, Jean

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Aging, Cardiovascular, Clinical Research, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Age Factors, Aged, Aged, 80 and over, Cardiovascular Diseases, Diabetes Mellitus, Female, Humans, Incidence, Independent Living, Middle Aged, Mortality, Mouth, Edentulous, Multivariate Analysis, Periodontitis, Postmenopause, Proportional Hazards Models, Risk Factors, Smoking, Stroke, cardiovascular disease, epidemiology, mortality, periodontal disease, women's health, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

Few studies have reported associations between periodontitis and cardiovascular disease (CVD) risk in older women, which is the objective of the present investigation. Participants were 57 001 postmenopausal women ages 55 to 89 years (mean 68 years; >85% 60 and older) who were enrolled (1993-1998) in the Women's Health Initiative Observational Study, and were without known CVD when history of periodontitis and edentulism was assessed by questionnaire at study Year-5 (1998-2003). There were 3589 incident CVD events and 3816 total deaths during a mean follow-up of 6.7 years. In multivariable analysis, periodontitis was not associated with CVD events, but was associated with higher total mortality (hazard ratio (HR)=1.12, 95% CI: 1.05-1.21). Edentulism was associated with higher age- and smoking-adjusted risks of CVD (HR=1.42, 95% CI: 1.27-1.59) and mortality (HR=1.47, 95% CI: 1.32-1.63). Further adjustment eliminated the association with CVD, but mortality remained significantly increased (HR=1.17, 95% CI: 1.02-1.33). Stratification on age, race-ethnicity, smoking, and diabetes mellitus yielded comparable results; however, edentulism was more strongly associated with CVD in women reporting ≥1 dental visit (HR=1.57) compared with

Published
2017

11. Epigenome‐wide association study using peripheral blood leukocytes identifies genomic regions associated with periodontal disease and edentulism in the Atherosclerosis Risk in Communities study

Author

Zhao, Naisi, primary, Teles, Flavia, additional, Lu, Jiayun, additional, Koestler, Devin C., additional, Beck, James, additional, Boerwinkle, Eric, additional, Bressler, Jan, additional, Kelsey, Karl T., additional, Platz, Elizabeth A., additional, and Michaud, Dominique S., additional

Published
2023
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12. Epidemiology of Pancreatic Cancer

Author

Michaud, Dominique S., Loda, Massimo, editor, Mucci, Lorelei A., editor, Mittelstadt, Megan L., editor, Van Hemelrijck, Mieke, editor, and Cotter, Maura Bríd, editor

Published
2017
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13. Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium

Author

Elena, Joanne W, Steplowski, Emily, Yu, Kai, Hartge, Patricia, Tobias, Geoffrey S, Brotzman, Michelle J, Chanock, Stephen J, Stolzenberg-Solomon, Rachael Z, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Petersen, Gloria, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E, Amundadottir, Laufey, Bao, Ying, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Buring, Julie E, Gaziano, J Michael, Giovannucci, Edward L, Duell, Eric J, Hallmans, Göran, Howard, Barbara V, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Kooperberg, Charles, Kraft, Peter, Mendelsohn, Julie B, Michaud, Dominique S, Palli, Domenico, Phillips, Lawrence S, Overvad, Kim, Patel, Alpa V, Sansbury, Leah, Shu, Xiao-Ou, Simon, Michael S, Slimani, Nadia, Trichopoulos, Dimitrios, Visvanathan, Kala, Virtamo, Jarmo, Wolpin, Brian M, Zeleniuch-Jacquotte, Anne, Fuchs, Charles S, Hoover, Robert N, and Gross, Myron

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Services and Systems, Health Sciences, Oncology and Carcinogenesis, Rare Diseases, Cancer, Pancreatic Cancer, Prevention, Digestive Diseases, Clinical Research, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Good Health and Well Being, Adenocarcinoma, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Diabetes Complications, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Risk Factors, Public Health and Health Services, Oncology and carcinogenesis
Abstract

PurposeDiabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan).MethodsThe pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (

Published
2013

15. Genome-wide association study of glioma and meta-analysis

Author

Rajaraman, Preetha, Melin, Beatrice S, Wang, Zhaoming, McKean-Cowdin, Roberta, Michaud, Dominique S, Wang, Sophia S, Bondy, Melissa, Houlston, Richard, Jenkins, Robert B, Wrensch, Margaret, Yeager, Meredith, Ahlbom, Anders, Albanes, Demetrius, Andersson, Ulrika, Freeman, Laura E Beane, Buring, Julie E, Butler, Mary Ann, Braganza, Melissa, Carreon, Tania, Feychting, Maria, Fleming, Sarah J, Gapstur, Susan M, Gaziano, J Michael, Giles, Graham G, Hallmans, Goran, Henriksson, Roger, Hoffman-Bolton, Judith, Inskip, Peter D, Johansen, Christoffer, Kitahara, Cari M, Lathrop, Mark, Liu, Chenwei, Le Marchand, Loic, Linet, Martha S, Lonn, Stefan, Peters, Ulrike, Purdue, Mark P, Rothman, Nathaniel, Ruder, Avima M, Sanson, Marc, Sesso, Howard D, Severi, Gianluca, Shu, Xiao-Ou, Simon, Matthias, Stampfer, Meir, Stevens, Victoria L, Visvanathan, Kala, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Decker, Paul, Enciso-Mora, Victor, Fridley, Brooke, Gao, Yu-Tang, Kosel, Matthew, Lachance, Daniel H, Lau, Ching, Rice, Terri, Swerdlow, Anthony, Wiemels, Joseph L, Wiencke, John K, Shete, Sanjay, Xiang, Yong-Bing, Xiao, Yuanyuan, Hoover, Robert N, Fraumeni, Joseph F, Chatterjee, Nilanjan, Hartge, Patricia, and Chanock, Stephen J

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Clinical Research, Brain Disorders, Prevention, Brain Cancer, Neurosciences, Cancer, Human Genome, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Aged, Brain Neoplasms, Case-Control Studies, Cohort Studies, Cyclin-Dependent Kinase Inhibitor p15, DNA Helicases, Female, Genome-Wide Association Study, Glioblastoma, Glioma, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Telomerase, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity, Reproductive medicine
Abstract

Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk.

Published
2012

17. Variant ABO Blood Group Alleles, Secretor Status, and Risk of Pancreatic Cancer: Results from the Pancreatic Cancer Cohort Consortium

Author

Wolpin, Brian M, Kraft, Peter, Xu, Mousheng, Steplowski, Emily, Olsson, Martin L, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Petersen, Gloria, Stolzenberg-Solomon, Rachael Z, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E, Amundadottir, Laufey, Austin, Melissa A, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Chanock, Stephen J, Gaziano, J Michael, Giovannucci, Edward L, Hallmans, Göran, Hankinson, Susan E, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Kooperberg, Charles, Mendelsohn, Julie B, Michaud, Dominique S, Overvad, Kim, Patel, Alpa V, Sanchéz, Maria-José, Sansbury, Leah, Shu, Xiao-Ou, Slimani, Nadia, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Vineis, Paolo, Visvanathan, Kala, Virtamo, Jarmo, Wactawski-Wende, Jean, Watters, Joanne, Yu, Kai, Zeleniuch-Jacquotte, Anne, Hartge, Patricia, and Fuchs, Charles S

Subjects
Digestive Diseases, Cancer, Clinical Research, Genetics, Rare Diseases, Pancreatic Cancer, Prevention, Human Genome, Aetiology, 2.1 Biological and endogenous factors, ABO Blood-Group System, Alleles, Cohort Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Glycosyltransferases, Humans, Odds Ratio, Pancreatic Neoplasms, Phenotype, Polymorphism, Single Nucleotide, Medical and Health Sciences, Epidemiology
Abstract

BackgroundSubjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk.MethodsWe determined ABO variants and secretor phenotype from single nucleotide polymorphisms in ABO and FUT2 genes in 1,533 cases and 1,582 controls from 12 prospective cohort studies. Adjusted odds ratios (OR) for pancreatic cancer were calculated using logistic regression.ResultsAn increased risk was observed in participants with A(1) but not A(2) alleles. Compared with subjects with genotype O/O, genotypes A(2)/O, A(2)/A(1), A(1)/O, and A(1)/A(1) had ORs of 0.96 (95% CI, 0.72-1.26), 1.46 (95% CI, 0.98-2.17), 1.48 (95% CI, 1.23-1.78), and 1.71 (95% CI, 1.18-2.47). Risk was similar for O01 and O02 variant O alleles. Compared with O01/O01, the ORs for each additional allele of O02, A(1), and A(2) were 1.00 (95% CI, 0.87-1.14), 1.38 (95% CI, 1.20-1.58), and 0.96 (95% CI, 0.77-1.20); P, O01 versus O02 = 0.94, A(1) versus A(2) = 0.004. Secretor phenotype was not an effect modifier (P-interaction = 0.63).ConclusionsAmong participants in a large prospective cohort consortium, ABO allele subtypes corresponding to increased glycosyltransferase activity were associated with increased pancreatic cancer risk.ImpactThese data support the hypothesis that ABO glycosyltransferase activity influences pancreatic cancer risk rather than actions of other nearby genes on chromosome 9q34.

Published
2010

18. Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)

Author

Michaud, Dominique S, Vrieling, Alina, Jiao, Li, Mendelsohn, Julie B, Steplowski, Emily, Lynch, Shannon M, Wactawski-Wende, Jean, Arslan, Alan A, Bas Bueno-de-Mesquita, H, Fuchs, Charles S, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Petersen, Gloria, Zheng, Wei, Allen, Naomi, Ammundadottir, Laufey, Bergmann, Manuela M, Boffetta, Paolo, Buring, Julie E, Canzian, Federico, Chanock, Stephen J, Clavel-Chapelon, Françoise, Clipp, Sandra, Freiberg, Matthew S, Michael Gaziano, J, Giovannucci, Edward L, Hankinson, Susan, Hartge, Patricia, Hoover, Robert N, Allan Hubbell, F, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin, Kooperberg, Charles, Kraft, Peter, Manjer, Jonas, Navarro, Carmen, Peeters, Petra HM, Shu, Xiao-Ou, Stevens, Victoria, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Tumino, Rosario, Vineis, Paolo, Virtamo, Jarmo, Wallace, Robert, Wolpin, Brian M, Yu, Kai, Zeleniuch-Jacquotte, Anne, and Stolzenberg-Solomon, Rachael Z

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Alcoholism, Alcohol Use and Health, Cancer, Digestive Diseases, Pancreatic Cancer, Rare Diseases, Clinical Research, Substance Misuse, Oral and gastrointestinal, Good Health and Well Being, Aged, Alcohol Drinking, Case-Control Studies, Cohort Studies, Female, Humans, Male, Pancreatic Neoplasms, Prospective Studies, Alcohol, Pancreatic cancer, Pooled analysis, Oncology and Carcinogenesis, Public Health and Health Services, Epidemiology, Oncology and carcinogenesis
Abstract

The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. >0 to

Published
2010

19. Anthropometric Measures, Body Mass Index, and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)

Author

Arslan, Alan A, Helzlsouer, Kathy J, Kooperberg, Charles, Shu, Xiao-Ou, Steplowski, Emily, Bueno-de-Mesquita, H Bas, Fuchs, Charles S, Gross, Myron D, Jacobs, Eric J, Lacroix, Andrea Z, Petersen, Gloria M, Stolzenberg-Solomon, Rachael Z, Zheng, Wei, Albanes, Demetrius, Amundadottir, Laufey, Bamlet, William R, Barricarte, Aurelio, Bingham, Sheila A, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Buring, Julie E, Chanock, Stephen J, Clipp, Sandra, Gaziano, J Michael, Giovannucci, Edward L, Hankinson, Susan E, Hartge, Patricia, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Kraft, Peter, Lynch, Shannon M, Manjer, Jonas, Manson, Joann E, McTiernan, Anne, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Palli, Domenico, Rohan, Thomas E, Slimani, Nadia, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Wolpin, Brian M, Yu, Kai, Zeleniuch-Jacquotte, Anne, and Patel, Alpa V

Subjects
Obesity, Cancer, Clinical Research, Nutrition, Prevention, Pancreatic Cancer, Rare Diseases, Digestive Diseases, Adult, Aged, Aged, 80 and over, Body Mass Index, Case-Control Studies, Female, Humans, Logistic Models, Male, Middle Aged, Overweight, Pancreatic Neoplasms, Risk Factors, Sex Distribution, United States, Waist Circumference, Pancreatic Cancer Cohort Consortium, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services
Abstract

BackgroundObesity has been proposed as a risk factor for pancreatic cancer.MethodsPooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, or = 35.0). Models were adjusted for potential confounders.ResultsIn all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; P(trend) < .001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; P(trend) < .03), and in women it was 1.34 (95% CI, 1.05-1.70; P(trend) = .01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; P(trend) = .003) but less so in men.ConclusionsThese findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.

Published
2010

20. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

Author

Petersen, Gloria M, Amundadottir, Laufey, Fuchs, Charles S, Kraft, Peter, Stolzenberg-Solomon, Rachael Z, Jacobs, Kevin B, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gallinger, Steven, Gross, Myron, Helzlsouer, Kathy, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, LaCroix, Andrea, Li, Donghui, Mandelson, Margaret T, Olson, Sara H, Risch, Harvey A, Zheng, Wei, Albanes, Demetrius, Bamlet, William R, Berg, Christine D, Boutron-Ruault, Marie-Christine, Buring, Julie E, Bracci, Paige M, Canzian, Federico, Clipp, Sandra, Cotterchio, Michelle, de Andrade, Mariza, Duell, Eric J, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hassan, Manal, Howard, Barbara, Hunter, David J, Hutchinson, Amy, Jenab, Mazda, Kaaks, Rudolf, Kooperberg, Charles, Krogh, Vittorio, Kurtz, Robert C, Lynch, Shannon M, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Parikh, Hemang, Patel, Alpa V, Peeters, Petra HM, Rajkovic, Aleksandar, Riboli, Elio, Rodriguez, Laudina, Seminara, Daniela, Shu, Xiao-Ou, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Van Den Eeden, Stephen K, Virtamo, Jarmo, Wactawski-Wende, Jean, Wang, Zhaoming, Wolpin, Brian M, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Fraumeni, Joseph F, Hoover, Robert N, Hartge, Patricia, and Chanock, Stephen J

Subjects
Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 13, Humans, Carcinoma, Pancreatic Neoplasms, Genetic Predisposition to Disease, Case-Control Studies, Cohort Studies, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci, Rare Diseases, Cancer, Genetics, Clinical Research, Pancreatic Cancer, Digestive Diseases, Human Genome, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

Published
2010

21. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.

Author

Wolpin, Brian M, Kraft, Peter, Gross, Myron, Helzlsouer, Kathy, Bueno-de-Mesquita, H Bas, Steplowski, Emily, Stolzenberg-Solomon, Rachael Z, Arslan, Alan A, Jacobs, Eric J, Lacroix, Andrea, Petersen, Gloria, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E, Amundadottir, Laufey, Anderson, Garnet, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Chanock, Stephen J, Clipp, Sandra, Gaziano, John Michael, Giovannucci, Edward L, Hallmans, Göran, Hankinson, Susan E, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin, Kooperberg, Charles, Lynch, Shannon M, Mendelsohn, Julie B, Michaud, Dominique S, Overvad, Kim, Patel, Alpa V, Rajkovic, Aleksandar, Sanchéz, Maria-José, Shu, Xiao-Ou, Slimani, Nadia, Thomas, Gilles, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Vineis, Paolo, Virtamo, Jarmo, Wactawski-Wende, Jean, Yu, Kai, Zeleniuch-Jacquotte, Anne, Hartge, Patricia, and Fuchs, Charles S

Subjects
Humans, Pancreatic Neoplasms, Genetic Predisposition to Disease, ABO Blood-Group System, Logistic Models, Odds Ratio, Risk Factors, Cohort Studies, Gene Frequency, Genotype, Alleles, Aged, Middle Aged, Female, Male, Clinical Research, Genetics, Pancreatic Cancer, Rare Diseases, Digestive Diseases, Cancer, Prevention, 2.1 Biological and endogenous factors, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.

Published
2010

22. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

Author

Amundadottir, Laufey, Kraft, Peter, Stolzenberg-Solomon, Rachael Z, Fuchs, Charles S, Petersen, Gloria M, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Zheng, Wei, Albanes, Demetrius, Bamlet, William, Berg, Christine D, Berrino, Franco, Bingham, Sheila, Buring, Julie E, Bracci, Paige M, Canzian, Federico, Clavel-Chapelon, Françoise, Clipp, Sandra, Cotterchio, Michelle, de Andrade, Mariza, Duell, Eric J, Fox, John W, Gallinger, Steven, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, González, Carlos A, Hallmans, Göran, Hankinson, Susan E, Hassan, Manal, Holly, Elizabeth A, Hunter, David J, Hutchinson, Amy, Jackson, Rebecca, Jacobs, Kevin B, Jenab, Mazda, Kaaks, Rudolf, Klein, Alison P, Kooperberg, Charles, Kurtz, Robert C, Li, Donghui, Lynch, Shannon M, Mandelson, Margaret, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Olson, Sara H, Overvad, Kim, Patel, Alpa V, Peeters, Petra HM, Rajkovic, Aleksandar, Riboli, Elio, Risch, Harvey A, Shu, Xiao-Ou, Thomas, Gilles, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Van Den Eeden, Stephen K, Virtamo, Jarmo, Wactawski-Wende, Jean, Wolpin, Brian M, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen J, Hartge, Patricia, and Hoover, Robert N

Subjects
Chromosomes, Human, Pair 9, Humans, Pancreatic Neoplasms, Genetic Predisposition to Disease, ABO Blood-Group System, Logistic Models, Odds Ratio, Risk Factors, Case-Control Studies, Cohort Studies, Prospective Studies, Gene Frequency, Genotype, Haplotypes, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Alleles, Introns, United States, Female, Male, Genetic Variation, Genome-Wide Association Study, Prevention, Rare Diseases, Cancer, Genetics, Clinical Research, Pancreatic Cancer, Digestive Diseases, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

Published
2009

23. Alterations in the Fungal Microbiome in Ulcerative Colitis

Author

Hsia, Katie, primary, Zhao, Naisi, additional, Chung, Mei, additional, Algarrahi, Khalid, additional, Kouhsari, Laleh Montaser, additional, Fu, May, additional, Chen, Hannah, additional, Singh, Siddharth, additional, Michaud, Dominique S, additional, and Jangi, Sushrut, additional

Published
2023
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26. Data from Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study

Author

Michaud, Dominique S., primary, Bové, Gerald, primary, Gallo, Valentina, primary, Schlehofer, Brigitte, primary, Tjønneland, Anne, primary, Olsen, Anja, primary, Overvad, Kim, primary, Dahm, Christina C., primary, Teucher, Brigit, primary, Boeing, Heiner, primary, Steffen, Annika, primary, Trichopoulou, Antonia, primary, Bamia, Christina, primary, Kyrozis, Andreas, primary, Sacerdote, Carlotta, primary, Agnoli, Claudia, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Mattiello, Amalia, primary, Bueno-de-Mesquita, H. Bas, primary, Peeters, Petra H. M., primary, May, Anne M., primary, Barricarte, Aurelio, primary, Chirlaque, Maria-Dolores, primary, Dorronsoro, Miren, primary, José Sánchez, Maria, primary, Rodríguez, Laudina, primary, Duell, Eric J., primary, Hallmans, Göran, primary, Melin, Beatrice S., primary, Manjer, Jonas, primary, Borgquist, Signe, primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Allen, Naomi E., primary, Travis, Ruth C., primary, Romieu, Isabelle, primary, Vineis, Paolo, primary, and Riboli, Elio, primary

Published
2023
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27. Supplementary Method 1, Tables S1-S8, and Figures S1-S2 from Periodontal and Other Oral Bacteria and Risk of Lung Cancer in the Atherosclerosis Risk in Communities (ARIC) Study

Author

Zhou, Baijun, primary, Lu, Jiayun, primary, Beck, James D., primary, Moss, Kevin L., primary, Prizment, Anna E., primary, Demmer, Ryan T., primary, Porosnicu Rodriguez, Kori A., primary, Joshu, Corinne E., primary, Michaud, Dominique S., primary, and Platz, Elizabeth A., primary

Published
2023
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28. Perspective on This Article from Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study

Author

Michaud, Dominique S., primary, Bové, Gerald, primary, Gallo, Valentina, primary, Schlehofer, Brigitte, primary, Tjønneland, Anne, primary, Olsen, Anja, primary, Overvad, Kim, primary, Dahm, Christina C., primary, Teucher, Brigit, primary, Boeing, Heiner, primary, Steffen, Annika, primary, Trichopoulou, Antonia, primary, Bamia, Christina, primary, Kyrozis, Andreas, primary, Sacerdote, Carlotta, primary, Agnoli, Claudia, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Mattiello, Amalia, primary, Bueno-de-Mesquita, H. Bas, primary, Peeters, Petra H. M., primary, May, Anne M., primary, Barricarte, Aurelio, primary, Chirlaque, Maria-Dolores, primary, Dorronsoro, Miren, primary, José Sánchez, Maria, primary, Rodríguez, Laudina, primary, Duell, Eric J., primary, Hallmans, Göran, primary, Melin, Beatrice S., primary, Manjer, Jonas, primary, Borgquist, Signe, primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Allen, Naomi E., primary, Travis, Ruth C., primary, Romieu, Isabelle, primary, Vineis, Paolo, primary, and Riboli, Elio, primary

Published
2023
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29. What is the cost-effectiveness of menu calorie labelling on reducing obesity-associated cancer burdens? An economic evaluation of a federal policy intervention among 235 million adults in the USA

Author

Du, Mengxi, primary, Griecci, Christina F, additional, Cudhea, Frederick, additional, Eom, Heesun, additional, Wong, John B, additional, Wilde, Parke, additional, Kim, David D, additional, Michaud, Dominique S, additional, Wang, Y Claire, additional, Mozaffarian, Dariush, additional, and Zhang, Fang Fang, additional

Published
2023
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30. Obesity and Pancreatic Cancer

Author

Michaud, Dominique S., Schlag, Peter M., Series editor, Senn, Hans-Jörg, Series editor, Pischon, Tobias, editor, and Nimptsch, Katharina, editor

Published
2016
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34. List of Contributors

Author

Adams, Susan, primary, Babady, Esther, additional, Borody, Thomas, additional, Chen, Fei, additional, Cher, Jonathan, additional, Cox, Michael R., additional, El-Assaad, Fatima, additional, El-Omar, Emad M., additional, Eslick, Guy D., additional, Frean, John, additional, Freyer, Carl, additional, Gia, Andrew, additional, Gong, Lan, additional, Green, Peter H., additional, Grover, Madhusudan, additional, Gurunathan, Sakteesh V., additional, Holtmann, Gerald, additional, Hosseini, Mojgan, additional, Keddy, Karen Helena, additional, Krishnareddy, Suneeta, additional, Lamps, Laura W., additional, Mans, Janet, additional, Mead, Peter, additional, Michaud, Dominique S., additional, Moos, Verena, additional, Nadan, Sandrama, additional, Nesvaderani, Maryam, additional, Nobel, Yael, additional, Page, Nicola Anne, additional, Park, Min Young, additional, Penninkilampi, Ross, additional, Shah, Ayesha, additional, Shrestha, Prapti, additional, Singh, Arunjot, additional, Smith, Anthony M., additional, Wu, Camille, additional, Yim, Howard Chi Ho, additional, and Zekry, Amany, additional

Published
2019
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35. Supplementary Tables 1-3 from Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort Consortium

Author

Wolpin, Brian M., primary, Kraft, Peter, primary, Gross, Myron, primary, Helzlsouer, Kathy, primary, Bueno-de-Mesquita, H. Bas, primary, Steplowski, Emily, primary, Stolzenberg-Solomon, Rachael Z., primary, Arslan, Alan A., primary, Jacobs, Eric J., primary, LaCroix, Andrea, primary, Petersen, Gloria, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Allen, Naomi E., primary, Amundadottir, Laufey, primary, Anderson, Garnet, primary, Boutron-Ruault, Marie-Christine, primary, Buring, Julie E., primary, Canzian, Federico, primary, Chanock, Stephen J., primary, Clipp, Sandra, primary, Gaziano, John Michael, primary, Giovannucci, Edward L., primary, Hallmans, Göran, primary, Hankinson, Susan E., primary, Hoover, Robert N., primary, Hunter, David J., primary, Hutchinson, Amy, primary, Jacobs, Kevin, primary, Kooperberg, Charles, primary, Lynch, Shannon M., primary, Mendelsohn, Julie B., primary, Michaud, Dominique S., primary, Overvad, Kim, primary, Patel, Alpa V., primary, Rajkovic, Aleksandar, primary, Sanchéz, Maria-José, primary, Shu, Xiao-Ou, primary, Slimani, Nadia, primary, Thomas, Gilles, primary, Tobias, Geoffrey S., primary, Trichopoulos, Dimitrios, primary, Vineis, Paolo, primary, Virtamo, Jarmo, primary, Wactawski-Wende, Jean, primary, Yu, Kai, primary, Zeleniuch-Jacquotte, Anne, primary, Hartge, Patricia, primary, and Fuchs, Charles S., primary

Published
2023
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36. Data from Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort Consortium

Author

Wolpin, Brian M., primary, Kraft, Peter, primary, Gross, Myron, primary, Helzlsouer, Kathy, primary, Bueno-de-Mesquita, H. Bas, primary, Steplowski, Emily, primary, Stolzenberg-Solomon, Rachael Z., primary, Arslan, Alan A., primary, Jacobs, Eric J., primary, LaCroix, Andrea, primary, Petersen, Gloria, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Allen, Naomi E., primary, Amundadottir, Laufey, primary, Anderson, Garnet, primary, Boutron-Ruault, Marie-Christine, primary, Buring, Julie E., primary, Canzian, Federico, primary, Chanock, Stephen J., primary, Clipp, Sandra, primary, Gaziano, John Michael, primary, Giovannucci, Edward L., primary, Hallmans, Göran, primary, Hankinson, Susan E., primary, Hoover, Robert N., primary, Hunter, David J., primary, Hutchinson, Amy, primary, Jacobs, Kevin, primary, Kooperberg, Charles, primary, Lynch, Shannon M., primary, Mendelsohn, Julie B., primary, Michaud, Dominique S., primary, Overvad, Kim, primary, Patel, Alpa V., primary, Rajkovic, Aleksandar, primary, Sanchéz, Maria-José, primary, Shu, Xiao-Ou, primary, Slimani, Nadia, primary, Thomas, Gilles, primary, Tobias, Geoffrey S., primary, Trichopoulos, Dimitrios, primary, Vineis, Paolo, primary, Virtamo, Jarmo, primary, Wactawski-Wende, Jean, primary, Yu, Kai, primary, Zeleniuch-Jacquotte, Anne, primary, Hartge, Patricia, primary, and Fuchs, Charles S., primary

Published
2023
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44. Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

Author

Michaud, Dominique S., Izard, Jacques, Rubin, Zachary, Johansson, Ingegerd, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Dossus, Laure, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Naska, Androniki, Ziara, Giana, Vineis, Paolo, Grioni, Sara, Palli, Domenico, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H. M., Siersema, Peter D., Barricarte, Aurelio, Huerta, José-María, Molina-Montes, Esther, Dorronsoro, Miren, Quirós, J. Ramón, Duell, Eric J., Ohlsson, Bodil, Jeppsson, Bengt, Johansson, Anders, Lif, Pernilla, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Key, Tim J., Freisling, Heinz, Duarte-Salles, Talita, Stepien, Magdalena, Riboli, Elio, and Bueno-de-Mesquita, H. Bas

Published
2013

45. Periodontal and Other Oral Bacteria and Risk of Lung Cancer in the Atherosclerosis Risk in Communities (ARIC) Study.

Author

Baijun Zhou, Jiayun Lu, Beck, James D., Moss, Kevin L., Prizment, Anna E., Demmer, Ryan T., Rodriguez, Kori A. Porosnicu, Joshu, Corinne E., Michaud, Dominique S., and Platz, Elizabeth A.

Abstract

Background: Evidence suggests that periodontal disease is associated with increased lung cancer risk, but whether periodontal pathogens are explanatory is unknown. We prospectively studied associations of prediagnostic circulating antibodies with oral bacteria and of periodontal bacteria in subgingival plaque with lung cancer. Methods: We included 4,263 cancer-free participants in the Atherosclerosis Risk in Communities study with previously measured serum IgG antibodies to 18 oral bacteria. In 1,287 participants for whom subgingival plaque was collected, counts for 8 periodontal bacteria were previously measured. Incident lung cancers (N = 118) were ascertained through 2015 (median follow-up = 17.5 years). We used Cox regression to estimate multivariable-adjusted associations, including for sums of antibodies to orange (C. rectus, F. nucleatum, P. intermedia, P. micra, and P. nigrescens) and red (P. gingivalis, T. forsythensis, and T. denticola) complex bacteria. Results: Orange complex bacteria antibodies were positively associated with lung cancer [per IQR hazard ratios (HR) = 1.15; 95% confidence intervals (CI), 1.02-1.29], which was stronger in men (HR = 1.27, 95% CI 1.08-1.49), and explained by P. intermedia and P. nigrescens (HR = 1.15; 95% CI, 1.04-1.26). Suggestive positive associations with lung cancer (N = 40) were observed for F. nucleatum, A. actinomycetemcomitans, and P. gingivalis counts. Significant positive associations were found for the count to antibody ratio for P. intermedia and P. gingivalis. Conclusions: We identified positive associations with lung cancer for oral bacteria, especially orange complex that are moderately pathogenic for periodontal disease. Impact: This prospective study supports the need for more research on periodontal bacteria in lung cancer etiology. If associations are supported, this may inform novel lung cancer prevention strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Intake of Coffee, Decaffeinated Coffee, or Tea Does Not Affect Risk for Pancreatic Cancer: Results From the European Prospective Investigation into Nutrition and Cancer Study

Author

Bhoo–Pathy, Nirmala, Uiterwaal, Cuno S.P.M., Dik, Vincent K., Jeurnink, Suzanne M., Bech, Bodil H., Overvad, Kim, Halkjær, Jytte, Tjønneland, Anne, Boutron–Ruault, Marie–Christine, Fagherazzi, Guy, Racine, Antoine, Katzke, Verena A., Li, Kuanrong, Boeing, Heiner, Floegel, Anna, Androulidaki, Anna, Bamia, Christina, Trichopoulou, Antonia, Masala, Giovanna, Panico, Salvatore, Crosignani, Paolo, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H.M., Gavrilyuk, Oxana, Skeie, Guri, Weiderpass, Elisabete, Duell, Eric J., Arguelles, Marcial, Molina–Montes, Esther, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Lindkvist, Björn, Wallström, Peter, Sund, Malin, Ye, Weimin, Khaw, Kay–Tee, Wareham, Nick, Key, Timothy J., Travis, Ruth C., Duarte–Salles, Talita, Freisling, Heinz, Licaj, Idlir, Gallo, Valentina, Michaud, Dominique S., Riboli, Elio, and Bueno–De–Mesquita, H. Bas

Published
2013
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49. Tooth count, untreated caries and mortality in US adults: a population-based cohort study

Author

Liu, Jie, primary, Zong, Xiaoyu, additional, Vogtmann, Emily, additional, Cao, Chao, additional, James, Aimee S, additional, Chan, Andrew T, additional, Rimm, Eric B, additional, Hayes, Richard B, additional, Colditz, Graham A, additional, Michaud, Dominique S, additional, Joshipura, Kaumudi J, additional, Abnet, Christian C, additional, and Cao, Yin, additional

Published
2022
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