1,160 results on '"Michaelis, M"'
Search Results
2. Preclinical assessment of integrin receptors as therapeutic targets in advanced treatment-resistant prostate cancer
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Tsaur, I., primary, Saar, M., additional, Juengel, E., additional, Vakhrusheva, O., additional, Slade, K.S., additional, Michaelis, M., additional, Rothweiler, F., additional, Cinatl, J., additional, Menger, M.D., additional, Linxweiler, J., additional, and Blaheta, R.A., additional
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- 2024
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3. Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors
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Sharma, N., Drobinski, P., Kayed, A., Chen, Z., Kjelgaard-Petersen, C.F., Gantzel, T., Karsdal, M.A., Michaelis, M., Ladel, C., Bay-Jensen, A.C., Lindemann, S., and Thudium, C.S.
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- 2020
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4. Dienstmodellanpassung für Ärzte in einer Universitätskinderklinik: Was ist möglich zur Verbesserung der Arbeitszeitgesetzkonformität und der Arbeitsbedingungen?
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Maschmann, J., Michaelis, M., Mihaljevic, J. S., Rieger, M. A., Handgretinger, R., Krägeloh-Mann, I., Wilke, M., and Holderried, M.
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- 2020
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5. Material Characterization of 3D Printed Components with Different Layup Orientation
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Bae, H., primary, Michaelis, M., additional, Black, V., additional, Navarra, N., additional, and Hossain, A., additional
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- 2021
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6. mTOR/AKT pathway: New insights for dianostic and therapeutic care in penile cancer
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Vakhrusheva, O., primary, Thomas, A., additional, Huck, S., additional, Slade, K., additional, Michaelis, M., additional, Cinatl, J., additional, Rotweiler, F., additional, Haferkamp, A., additional, Juengel, E., additional, Chinatl, J., additional, and Tsaur, I., additional
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- 2023
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7. Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo
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Reker, D., Siebuhr, A. S., Thudium, C. S., Gantzel, T., Ladel, C., Michaelis, M., Aspberg, A., Berchtold, M. W., Karsdal, M. A., Gigout, A., and Bay-Jensen, A. C.
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- 2020
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8. Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future
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Karsdal, M.A., Michaelis, M., Ladel, C., Siebuhr, A.S., Bihlet, A.R., Andersen, J.R., Guehring, H., Christiansen, C., Bay-Jensen, A.C., and Kraus, V.B.
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- 2016
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9. Berufskraftfahrer-Gesundheit – Ist Prävention möglich?
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Michaelis, M., Badura, Bernhard, editor, Ducki, Antje, editor, Schröder, Helmut, editor, Klose, Joachim, editor, and Meyer, Markus, editor
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- 2015
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10. Unhatched bovine blastocysts express all transcripts of the estrogen biosynthetic pathway, but steroid hormone synthesis could not yet be demonstrated
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Fürbass, R., primary, Michaelis, M., additional, and Schuler, G., additional
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- 2023
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11. Norovirusausbrüche und Kooperation zwischen Hygienepersonal und Betriebsärzten im Krankenhaus: Ergebnisse einer Umfrage bei Kongressteilnehmern
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Michaelis, M., Hofmann, F. M., Stößel, U., and Hofmann, F.
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- 2017
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12. Solution structure of paxillin LIM2/3
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Prestel, A., primary, Michaelis, M., additional, Klishin, N., additional, and Moeller, H.M., additional
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- 2022
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13. Metastasis of cisplatin-resistant bladder cancer cells is impaired by artesunate through inhibition of integrin subtypes
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Vakhrusheva, O., primary, Zhao, F., additional, Markowitsch, S.D., additional, Slade, K.S., additional, Mager, R., additional, Cinatl Jr., J., additional, Michaelis, M., additional, Efferth, T., additional, Haferkamp, A., additional, and Jüngel, E., additional
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- 2022
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14. R399E, a mutated form of GDF5, for disease modification of osteoarthritis
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Gigout, A., primary, Wekmann, D., additional, Menges, S., additional, Brenneis, C., additional, Henson, F., additional, Cowan, K.J., additional, Musil, D., additional, Thudium, C., additional, Guehring, H., additional, Michaelis, M., additional, and Kleinschmidt-Doerr, K., additional
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- 2022
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15. Plasticization and antiplasticization of an acrylic pressure sensitive adhesive by ibuprofen and their effect on the adhesion properties
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Michaelis, M., Brummer, R., and Leopold, C.S.
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- 2014
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16. Measurement Uncertainty and its Influence on Dynamic Object Tracking in Autonomous Driving
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Naujoks, B., primary, Engler, T., additional, Michaelis, M., additional, and Wuensche, H.-J., additional
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- 2017
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17. Impfbereitschaft bei Medizinstudierenden und Ärztinnen – Ein Lehr- und Forschungsprojekt an der Universität Freiburg im WS 2021/22
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Stößel, U, additional and Michaelis, M, additional
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- 2022
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18. P51 Characterization of Misdiagnosed Opsoclonus Myoclonus Ataxia Syndrome (OMAS)
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Michaelis, M. and Milligan, S.
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- 2024
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19. Der Einfluss der Resistenz gegen Cisplatin und Osimertinib auf das Metastasierungsverhalten des penilen Plattenepithelkarzinoms
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Slade, K., Thomas, A., Huck, S., Vakhrusheva, O., Michaelis, M., Cinatl, J., Rothweiler, F., Haferkamp, A., Jüngel, E., and Tsaur, I.
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ddc: 610 ,Medicine and health - Abstract
Einleitung: Für das metastasierte Peniskarzinom (PeCa) gibt es derzeit keine kurative, erfolgreiche Behandlung und die schnell erworbene Resistenz gegen Chemotherapien verschlechtert die Prognose der Patienten dramatisch. Dennoch ist das Wissen über die genauen Resistenzmuster begrenzt. Wir [zum vollständigen Text gelangen Sie über die oben angegebene URL]
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- 2022
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20. Die Reduktion von Integrin α6 durch Artesunat inhibiert das progressive Wachstum Docetaxel-resistenter Prostatakarzinomzellen
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Bräunig, V, Stein, L, Wüstefeld, L, Vakhrusheva, O, Markowitsch, S, Slade, K, Efferth, T, Culig, Z, Puhr, M, Michaelis, M, Cinatl, J, Haferkamp, A, and Jüngel, E
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ddc: 610 ,Medicine and health - Abstract
Einleitung: Therapieresistenzen stellen eines der größten Probleme in der Behandlung des fortgeschrittenen Prostatakarzinom (PCa), dem häufigsten Tumor des Mannes, dar. Neue Behandlungskonzepte werden daher dringend gesucht. Artesunat (ART) aus der Traditionellen Chinesischen Medizin [zum vollständigen Text gelangen Sie über die oben angegebene URL]
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- 2022
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21. Artesunat hemmt signifikant das Metastasierungsverhalten Cisplatin-resistenter Harnblasenkarzinomzellen
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Vakhrusheva, O., Zhao, F., Markowitsch, S., Michaelis, M., Cinatl, J., Efferth, T., Haferkamp, A., and Jüngel, E.
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ddc: 610 ,Medicine and health - Abstract
Einleitung: Zur Standardtherapie des metastasierten Harnblasenkarzinom (BCa) gehört die Cisplatin-basierte Chemotherapie. Das Therapieansprechen ist jedoch limitiert, so dass es zum Rezidiv kommt oder die Erkrankung in einen invasiven bzw. systemischen Progress fortschreitet. Dafür maßgeblich [zum vollständigen Text gelangen Sie über die oben angegebene URL]
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- 2022
22. Die Reduktion von Integrin alpha6 durch Artesunat inhibiert das progressive Wachstum Docetaxel-resistenter Prostatakarzinomzellen
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Bräunig, V, Stein, L, Wüstefeld, L, Vakhrusheva, O, Markowitsch, S, Slade, K, Efferth, T, Culig, Z, Puhr, M, Michaelis, M, Cinatl, J, Haferkamp, A, Jüngel, E, Bräunig, V, Stein, L, Wüstefeld, L, Vakhrusheva, O, Markowitsch, S, Slade, K, Efferth, T, Culig, Z, Puhr, M, Michaelis, M, Cinatl, J, Haferkamp, A, and Jüngel, E
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- 2022
23. Artesunat hemmt signifikant das Metastasierungsverhalten Cisplatin-resistenter Harnblasenkarzinomzellen
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Vakhrusheva, O, Zhao, F, Markowitsch, S, Michaelis, M, Cinatl, J, Efferth, T, Haferkamp, A, Jüngel, E, Vakhrusheva, O, Zhao, F, Markowitsch, S, Michaelis, M, Cinatl, J, Efferth, T, Haferkamp, A, and Jüngel, E
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- 2022
24. Der Einfluss der Resistenz gegen Cisplatin und Osimertinib auf das Metastasierungsverhalten des penilen Plattenepithelkarzinoms
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Slade, K, Thomas, A, Huck, S, Vakhrusheva, O, Michaelis, M, Cinatl, J, Rothweiler, F, Haferkamp, A, Jüngel, E, Tsaur, I, Slade, K, Thomas, A, Huck, S, Vakhrusheva, O, Michaelis, M, Cinatl, J, Rothweiler, F, Haferkamp, A, Jüngel, E, and Tsaur, I
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- 2022
25. Correlation of inflammatory and proangiogenic cytokines from undiluted vitreous samples with spectral domain OCT scans, in untreated branch retinal vein occlusion
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Pfister M, Rothweiler F, Michaelis M, Cinatl J Jr, Schubert R, Koch FH, and Koss MJ
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Ophthalmology ,RE1-994 - Abstract
Marcel Pfister,1,4 Florian Rothweiler,2 Martin Michaelis,2 Jindrich Cinatl Jr,2 Ralf Schubert,3 Frank H Koch,1 Michael J Koss1,4 1Department of Ophthalmology, Goethe University, Frankfurt, Germany; 2Department of Virology, Goethe University, Frankfurt, Germany; 3Department of Pediatric Pulmonology, Allergy and Cystic Fibrosis, Children's Hospital, Goethe University, Frankfurt, Germany; 4Doheny Eye Institute, University of Southern California, Los Angeles, CA, USA Purpose: To assess the levels of inflammatory and angiogenic cytokines in undiluted vitreous from treatment-naïve patients with macular edema secondary to nonischemic branch retinal vein occlusion (BRVO), with flow cytometric bead array (CBA) and to correlate the results with subjective and multiple spectral-domain optical coherence tomography (SD-OCT) parameters. Methods: A total of 43 eyes from 43 patients (mean age 69.7 years, 23 male) were divided into groups of new, "fresh" (n = 28; mean duration after onset 4.1 months) and older BRVO (n = 15; 11.6 months). Because of macular edema, these patients underwent an intravitreal therapy combining a single-site 23 g core vitrectomy with bevacizumab and dexamethasone. Undiluted vitreous was then analyzed for interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor isoform A (VEGF-A) levels with CBA and correlated with visual acuity (VA), clinical parameters of BRVO (type and perfusion status), and morphologic parameters, such as central macular thickness, central retinal thickness, thickness of the neurosensory retina, thickness of the serous retinal detachment, and the disruption of the ellipsoid line (photoreceptor inner and outer segments) and the external limiting membrane, as measured with SD-OCT. Twenty-eight undiluted vitreous samples from patients with idiopathic, nonuveitis vitreous floaters served as the controls. Results: The mean IL-6 was 23.2 pg/mL (standard deviation, ±48.8), MCP-1 was 602.6 (±490.3), and VEGF-A was 161.8 (±314.3), and this was higher than in the control group, which had a mean IL-6 of 6.2 ± 3.4 pg/mL (P = 0.17), MCP-1 of 253.2 ± 73.5 (P < 0.0000001), and VEGF-A of 7.0 ± 4.9 (P < 0.003). In all BRVO samples, IL-6 correlated positively with MCP-1 and VEGF-A (correlation coefficient r = 0.79 and r = 0.46, respectively). VEGF-A was the only cytokine to correlate significantly with SD-OCT parameters (thickness of the neurosensory retina r = 0.31; disruption of the ellipsoid line r = 0.33). In the older BRVO group, there was a positive correlation between cytokines (IL-6 with MCP-1, r = 0.77; Il-6 with VEGF-A, r = 0.68; MCP-1 and VEGF-A, r = 0.68), whereas only IL-6 correlated with MCP-1 in the fresh group (r = 0.8). Conclusion: The inflammatory markers and VEGF-A were elevated in the vitreous fluid of patients with BRVO, and these correlated with one another. VEGF-A was more often correlated with the morphologic changes assessed by SD-OCT, whereas the inflammatory markers had no significant influence on SD-OCT changes. Keywords: vitreous samples, BRVO, VEGF, MCP, IL-6, CBA, SD-OCT
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- 2013
26. Einsatz von steuerbaren Filtern zur modellbasierten Segmentation von Fundusphotographien
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Kochner, B., Schuhmann, D., Michaelis, M., Obermaier, M., Bek, T., Mann, G., Englmeier, K.-H., Lehmann, Thomas, editor, Metzler, Volker, editor, Spitzer, Klaus, editor, and Tolxdorff, Thomas, editor
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- 1998
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27. Segmentation of MR images with B-spline snakes: A multi-resolution approach using the distance transformation for model forces
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Stammberger, T., Rudert, S., Michaelis, M., Reiser, M., Englmeier, K.-H., Lehmann, Thomas, editor, Metzler, Volker, editor, Spitzer, Klaus, editor, and Tolxdorff, Thomas, editor
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- 1998
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28. Bandscheibenerkrankungen und Wirbelsäulenbeschwerden im Pflegeberuf. Die internationale Freiburger Wirbelsäulenstudie
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Hofmann, F., Michaelis, M., Nübling, M., Stössel, U., Wolter, D., editor, and Seide, K., editor
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- 1998
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29. Detektion und Verifikation von charakteristischen Bildpunkten in Gesichtsbildern
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Herpers, R., Witta, L., Michaelis, M., Bruske, J., Sommer, G., Brauer, W., editor, Jähne, Bernd, editor, Geißler, Peter, editor, Haußecker, Horst, editor, and Hering, Frank, editor
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- 1996
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30. Bandscheibenbedingte Erkrankungen der Wirbelsäule — Untersuchungen zur Frage der beruflichen Verursachung
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Hofmann, F., Michaelis, M., Siegel, A., Stößel, U., Stroink, U., Wolter, Dietmar, editor, and Seide, Klaus, editor
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- 1995
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31. Impact of resistance to cisplatin and osimertinib on dissemination properties of penile cancer cells
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Thomas, A., primary, Huck, S., additional, Slade, K.S., additional, Vakhrusheva, O., additional, Michaelis, M., additional, Cinatl, J.J., additional, Cinatl, J., additional, Rothweiler, F., additional, Haferkamp, A., additional, Juengel, E., additional, and Tsaur, I., additional
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- 2022
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32. Low levels of type II collagen formation (PRO-C2) are associated with response to sprifermin: a pre-defined, exploratory biomarker analysis from the FORWARD study
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Bay-Jensen, A.C., primary, Manginelli, A.A., additional, Karsdal, M., additional, Luo, Y., additional, He, Y., additional, Michaelis, M., additional, Guehring, H., additional, and Ladel, C., additional
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- 2022
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33. Junction classification by multiple orientation detection
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Michaelis, M., Sommer, G., Goos, Gerhard, editor, Hartmanis, Juris, editor, and Eklundh, Jan-Olof, editor
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- 1994
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34. miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells
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Takwi, A A, Wang, Y-M, Wu, J, Michaelis, M, Cinatl, J, and Chen, T
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- 2014
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35. Zur Frage berufsbedingter Erkrankungen der Lendenwirbelsäule aus arbeitsmedizinischer Sicht
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Hofmann, F., Düringer, C., Michaelis, M., Siegel, A., Stössel, U., Stroinck, U., Hierholzer, Günther, editor, Kunze, Georg, editor, and Peters, Dirk, editor
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- 1993
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36. Large expert-curated database for benchmarking document similarity detection in biomedical literature search
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Brown, P, Zhou, Y, Tan, A, El-Esawi, M, Liehr, T, Blanck, O, Gladue, D, Almeida, G, Cernava, T, Sorzano, C, Yeung, A, Engel, M, Chandrasekaran, A, Muth, T, Staege, M, Daulatabad, S, Widera, D, Zhang, J, Meule, A, Honjo, K, Pourret, O, Yin, C, Zhang, Z, Cascella, M, Flegel, W, Goodyear, C, van Raaij, M, Bukowy-Bieryllo, Z, Campana, L, Kurniawan, N, Lalaouna, D, Huttner, F, Ammerman, B, Ehret, F, Cobine, P, Tan, E, Han, H, Xia, W, Mccrum, C, Dings, R, Marinello, F, Nilsson, H, Nixon, B, Voskarides, K, Yang, L, Costa, V, Bengtsson-Palme, J, Bradshaw, W, Grimm, D, Kumar, N, Martis, E, Prieto, D, Sabnis, S, Amer, S, Liew, A, Perco, P, Rahimi, F, Riva, G, Zhang, C, Devkota, H, Ogami, K, Basharat, Z, Fierz, W, Siebers, R, Tan, K, Boehme, K, Brenneisen, P, Brown, J, Dalrymple, B, Harvey, D, Ng, G, Werten, S, Bleackley, M, Dai, Z, Dhariwal, R, Gelfer, Y, Hartmann, M, Miotla, P, Tamaian, R, Govender, P, Gurney-Champion, O, Kauppila, J, Zhang, X, Echeverria, N, Subhash, S, Sallmon, H, Tofani, M, Bae, T, Bosch, O, Cuiv, P, Danchin, A, Diouf, B, Eerola, T, Evangelou, E, Filipp, F, Klump, H, Kurgan, L, Smith, S, Terrier, O, Tuttle, N, Ascher, D, Janga, S, Schulte, L, Becker, D, Browngardt, C, Bush, S, Gaullier, G, Ide, K, Meseko, C, Werner, G, Zaucha, J, Al-Farha, A, Greenwald, N, Popoola, S, Rahman, S, Xu, J, Yang, S, Hiroi, N, Alper, O, Baker, C, Bitzer, M, Chacko, G, Debrabant, B, Dixon, R, Forano, E, Gilliham, M, Kelly, S, Klempnauer, K, Lidbury, B, Lin, M, Lynch, I, Ma, W, Maibach, E, Mather, D, Nandakumar, K, Ohgami, R, Parchi, P, Tressoldi, P, Xue, Y, Armitage, C, Barraud, P, Chatzitheochari, S, Coelho, L, Diao, J, Doxey, A, Gobet, A, Hu, P, Kaiser, S, Mitchell, K, Salama, M, Shabalin, I, Song, H, Stevanovic, D, Yadollahpour, A, Zeng, E, Zinke, K, Alimba, C, Beyene, T, Cao, Z, Chan, S, Gatchell, M, Kleppe, A, Piotrowski, M, Torga, G, Woldesemayat, A, Cosacak, M, Haston, S, Ross, S, Williams, R, Wong, A, Abramowitz, M, Effiong, A, Lee, S, Abid, M, Agarabi, C, Alaux, C, Albrecht, D, Atkins, G, Beck, C, Bonvin, A, Bourke, E, Brand, T, Braun, R, Bull, J, Cardoso, P, Carter, D, Delahay, R, Ducommun, B, Duijf, P, Epp, T, Eskelinen, E, Fallah, M, Farber, D, Fernandez-Triana, J, Feyerabend, F, Florio, T, Friebe, M, Furuta, S, Gabrielsen, M, Gruber, J, Grybos, M, Han, Q, Heinrich, M, Helantera, H, Huber, M, Jeltsch, A, Jiang, F, Josse, C, Jurman, G, Kamiya, H, de Keersmaecker, K, Kristiansson, E, de Leeuw, F, Li, J, Liang, S, Lopez-Escamez, J, Lopez-Ruiz, F, Marchbank, K, Marschalek, R, Martin, C, Miele, A, Montagutelli, X, Morcillo, E, Nicoletti, R, Niehof, M, O'Toole, R, Ohtomo, T, Oster, H, Palma, J, Paterson, R, Peifer, M, Portilla, M, Portillo, M, Pritchard, A, Pusch, S, Raghava, G, Roberts, N, Ross, K, Schuele, B, Sergeant, K, Shen, J, Stella, A, Sukocheva, O, Uversky, V, Vanneste, S, Villet, M, Viveiros, M, Vorholt, J, Weinstock, C, Yamato, M, Zabetakis, I, Zhao, X, Ziegler, A, Aizat, W, Atlas, L, Bridges, K, Chakraborty, S, Deschodt, M, Domingues, H, Esfahlani, S, Falk, S, Guisado, J, Kane, N, Kueberuwa, G, Lau, C, Liang, D, Liu, E, Luu, A, Ma, C, Ma, L, Moyer, R, Norris, A, Panthee, S, Parsons, J, Peng, Y, Pinto, I, Reschke, C, Sillanpaa, E, Stewart, C, Uhle, F, Yang, H, Zhou, K, Zhu, S, Ashry, M, Bergsland, N, Berthold, M, Chen, C, Colella, V, Cuypers, M, Eskew, E, Fan, X, Gajda, M, Gonzalezlez-Prendes, R, Goodin, A, Graham, E, Groen, E, Gutierrez-Sacristan, A, Habes, M, Heffler, E, Higginbottom, D, Janzen, T, Jayaraman, J, Jibb, L, Jongen, S, Kinyanjui, T, Koleva-Kolarova, R, Li, Z, Liu, Y, Lund, B, Lussier, A, Mier, P, Moore, M, Nagler, K, Orme, M, Pearson, J, Prajapati, A, Saito, Y, Troder, S, Uchendu, F, Verloh, N, Voutchkova, D, Abu-Zaid, A, Bakkach, J, Baumert, P, Dono, M, Hanson, J, Herbelet, S, Hobbs, E, Kulkarni, A, Liu, S, Loft, N, Reddan, T, Senghore, T, Vindin, H, Xu, H, Bannon, R, Chen, B, Cheung, J, Cooper, J, Esnakula, A, Feghali, K, Ghelardi, E, Gnasso, A, Horbar, J, Lai, H, Ma, R, Pan, Z, Peres, M, Pranata, R, Seow, E, Sydes, M, Testoni, I, Westermair, A, Yang, Y, Afnan, M, Albiol, J, Albuquerque, L, Amir, S, Amiya, E, Amorim, R, An, Q, Andersen, S, Aplin, J, Argyropoulos, C, Asmann, Y, Assaeed, A, Atanasov, A, Atchison, D, Avery, S, Avillach, P, Baade, P, Backman, L, Badie, C, Baldi, A, Ball, E, Bardot, O, Barnett, A, Basner, M, Batra, J, Bazanova, O, Beale, A, Beddoe, T, Bell, M, Berezikov, E, Berners-Price, S, Bernhardt, P, Berry, E, Bessa, T, Billington, C, Birch, J, Blakely, R, Blaskovich, M, Blum, R, Boelaert, M, Bogdanos, D, Bosch, C, Bourgoin, T, Bouvard, D, Boykin, L, Bradley, G, Braun, D, Brownlie, J, Bruhl, A, Burt, A, Butler, L, Byrareddy, S, Byrne, H, Cabantous, S, Calatayud, S, Candal, E, Carlson, K, Casillas, S, Castelvetro, V, Caswell, P, Cavalli, G, Cerovsky, V, Chagoyen, M, Chen, D, Chen, H, Chen, J, Chen, Y, Cheng, C, Cheng, J, Chinapaw, M, Chinopoulos, C, Cho, W, Chong, L, Chowdhury, D, Chwalibog, A, Ciresi, A, Cockcroft, S, Conesa, A, Cook, P, Cooper, D, Coqueret, O, Corea, E, Costa, A, Costa, E, Coupland, C, Crawford, S, Cruz, A, Cui, H, Cui, Q, Culver, D, D'Angiulli, A, Dahms, T, Daigle, F, Dalgleish, R, Danielsen, H, Darras, S, Davidson, S, Day, D, Degirmenci, V, Demaison, L, Devriendt, K, Ding, J, Dogan, Y, Dong, X, Donner, C, Dressick, W, Drevon, C, Duan, H, Ducho, C, Dumaz, N, Dwarakanath, B, Ebell, M, Eisenhardt, S, Elkum, N, Engel, N, Erickson, T, Fairhead, M, Faville, M, Fejzo, M, Festa, F, Feteira, A, Flood-Page, P, Forsayeth, J, Fox, S, Franks, S, Frentiu, F, Frilander, M, Fu, X, Fujita, S, Galea, I, Galluzzi, L, Gani, F, Ganpule, A, Garcia-Alix, A, Gedye, K, Giordano, M, Giunta, C, Gleeson, P, Goarant, C, Gong, H, Gora, D, Gough, M, Goyal, R, Graham, K, Grande-Perez, A, Graves, P, Greidanus, H, Grice, D, Grunau, C, Gumulya, Y, Guo, Y, Gurevich, V, Gusev, O, Hacker, E, Hage, S, Hagen, G, Hahn, S, Haller, D, Hammerschmidt, S, Han, J, Han, R, Handfield, M, Hapuarachchi, H, Harder, T, Hardingham, J, Heck, M, Heers, M, Hew, K, Higuchi, Y, 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J., Merlaen B., Messina R., Mishra A. K., Muhammad J., Musinguzi C., Nanou A., Naqash A., Nguyen J. T., Nguyen T. T. H., Ni D., Notcovich S., Ohst B., Ollivier Q. R., Osses D. F., Peng X., Plantinga A., Pulia M., Rafiq M., Raman A., Rawski R., Ray A., Razak L. A., Rudolf K., Rusch P., Sadoine M. L., Schmidt A., Schurr R., Searles S., Sharma S., Sheehan B., Shi C., Shohayeb B., Sommerlad A., Strehlow J., Sun X., Sundar R., Taherzadeh G., Tahir N. D. M., Tang J., Testa J., Tian Z., Tingting Q., Verheijen G. P., Vickstrom C., Wang T., Wang X., Wang Z., Wei P., Wilson A., Yassine A. -A., Yousefzadeh A., Zare A., Zeng Z., Zhang H., Zhou J., Zhu D., Adamo V., Adeyemo A. A., Aggelidou M., Al-Owaifeer A. M., Al-Riyami A. Z., Alzghari S. K., Andersen V., Angus K., Asaduzzaman M., Asady H., Ato D., Bai X., Baines R. L., Ballantyne M., Ban B., Beck J., Ben-Nafa W., Black E., Blancher A., Blankstein R., Bodagh N., Borges P., Brooks A., Brox-Ponce J., Brunetti A., Canham C. D., Carninci P., Carvajal R., Chang S. C., Chao J., Chatterjee P., Chen L., Chhatriwalla A. K., Chikowe I., Chuang T. -J., Collevatti R. G., Cornejo D. A. V., Cuenda A., Dao M., Dauga D., Deng Z., Devkota K., Doan L. V., Elewa Y. H. A., Fan D., Faruk M., Feifei S., Ferguson T. S., Fleres F., Foster E. J., Foster S., Furer T., Gao Y., Garcia-Rivera E. J., Gazdar A., George R. B., Ghosh S., Gianchecchi E., Gleason J. M., Hackshaw A., Hall A., Hall R., Harper P., Hogg W. E., Huang G., Hunter K. E., Ijzerman A. P., Jesus C., Jian G., Lewis J. S., Kanj S. S., Kaur H., Kheir F., Kichatova V. S., Kiyani M., Klein R., Kovesi T., Kraschnewski J. L., Kumar A. P., Labutin D., Lazo-Langner A., Leclercq G., Li M., Li Q., Li T., Liao W. -T., Liao Z. -Y., Lin J., Lizer J., Lobreglio G., Lowies C., Lu C., Majeed H., Martin A., Martinez-Sobrido L., Meresh E., Middelveen M., Mohebbi A., Mota J., Mozaheb Z., Muyaya L., Nandhakumar A., Ng S. H. X., Obeidat M., Oh D. -H., Owais M., Pace-Asciak P., Panwar A., Patterson C., Penagos-Tabaree F., Pianosi P. T., Pinzi V., Pridans C., Psaroulaki A., Pujala R. K., Pulido-Arjona L., Qi P. -F., Rahman P., Rai N. K., Rassaf T., Refardt J., Ricciardi W., Riess O., Rovas A., Sacks F. M., Saleh S., Sampson C., Schmutz A., Sepanski R., Sharma N., Spearman P., Subramaniapillai M., Swali R., Tan C. M., Tellechea J. I., Thomas L. -M., Tong X., Vavvas D. G., Veys R., Vitriol V., Wang H. -D., Waugh J., Webb S. A., Williams B. A., Workman A. D., Xiang T., Xie L. -X., Xu T., Yang C., Yoon J. G., Yuan C. M., Zaritsky A., Zhao H., Zuckerman H., Lyu R., and Pullan W.
- Abstract
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science.
- Published
- 2019
37. Gene expression signature of acquired chemoresistance in neuroblastoma cells
- Author
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Jemaa M., Sime W., Abassi Y., Lasorsa V. A., Kohler J. B., Michaelis M., Cinatl J., Capasso M., Massoumi R., Jemaa, M., Sime, W., Abassi, Y., Lasorsa, V. A., Kohler, J. B., Michaelis, M., Cinatl, J., Capasso, M., and Massoumi, R.
- Subjects
Prognosi ,Nocodazole ,Cell Cycle ,Antineoplastic Agents, Phytogenic ,Antineoplastic Agent ,Gene Expression Regulation, Neoplastic ,Neoplasm Protein ,Neuroblastoma ,Clone Cell ,Vincristine ,Drug Resistance, Neoplasm ,Cell Line, Tumor ,Cisplatin ,Transcriptome ,Chemoresistance ,Etoposide ,Human - Abstract
Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles.
- Published
- 2020
38. Discovery of epi-enprioline as a novel drug for the treatment of vincristine resistant neuroblastoma
- Author
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Sime W., Jemaa M., Abassi Y., Lasorsa V. A., Kohler J. B., Hansson K., Bexell D., Michaelis M., Cinatl J., Strand D., Capasso M., Massoumi R., Sime, W., Jemaa, M., Abassi, Y., Lasorsa, V. A., Kohler, J. B., Hansson, K., Bexell, D., Michaelis, M., Cinatl, J., Strand, D., Capasso, M., and Massoumi, R.
- Subjects
High-Throughput Screening Assay ,Animal ,Cell Survival ,Pyridine ,Apoptosi ,Mice, Nude ,Xenograft Model Antitumor Assays ,Antineoplastic Agent ,Neuroblastoma ,Mice ,Small Molecule Librarie ,Vincristine ,Doxorubicin ,Drug Resistance, Neoplasm ,Cell Line, Tumor ,Female ,Drug Screening Assays, Antitumor ,Chemoresistance ,Epi-enprioline ,Human - Abstract
Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule, epi-enprioline that was able to induce apoptosis of vincristine-resistant neuroblastoma cells via the mitochondrial apoptotic pathway. Epi-enprioline reduced tumour growth in multiple preclinical models, including an orthotopic neuroblastoma patient-derived xenograft model in vivo. In summary, our data suggest that epi-enprioline can be considered as a lead compound for the treatment of vincristine-resistant neuroblastoma uncovering a novel strategy, which can be further explored as a treatment for drug-resistant neuroblastoma.
- Published
- 2020
39. mTOR/Akt-Signalweg-Proteine als potentielle Biomarker beim Peniskarzinom
- Author
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Thomas, A., Reetz, S., Stenzel, P., Tagscherer, K., Roth, W., Vakhrusheva, O., Macher-Göppinger, S., Michaelis, M., Rothweiler, F., Cinatl, J., Haferkamp, A., Jüngel, E., and Tsaur, I.
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Peniskrebs (PeCa) ist ein seltenes, aber aggressives Malignom, das sich durch ein schnelles Tumorwachstum und lymphatische Metastasierung auszeichnet. Während insbesondere das Fehlen von Biomarkern beim Peniskarzinom (PeCa) wesentlichen Behandlungsfortschritten im Wege steht, deutet[zum vollständigen Text gelangen Sie über die oben angegebene URL], 61. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V.
- Published
- 2021
40. Shikonin aus der Traditionellen Chinesischen Medizin inhibiert das progressive Wachstum Docetaxel-resistenter Prostatakarzinome in vitro
- Author
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Jüngel, E, Markowitsch, S, Juetter, K, Schupp, P, Hauschulte, K, Vakhrusheva, O, Slade, K, Thomas, A, Tsaur, I, Cinatl, J, Michaelis, M, Efferth, T, and Haferkamp, A
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Das Prostatakarzinom (PCa) ist noch immer der häufigste Tumor des Mannes. Die Wirksamkeit der zugelassenen Therapeutika ist durch die Entstehung von Therapieresistenzen zeitlich limitieren. Neue Therapiekonzepte werden daher weiterhin dringend gesucht. Shikonin (SHI) aus der Traditionellen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 61. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V.
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- 2021
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- View/download PDF
41. Molekulare Mechanismen der Therapieresistenz zu Cisplatin und Osimertinib beim Peniskarzinom
- Author
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Thomas, A, Vakhrusheva, O, Cinatl, J, Rothweiler, F, Michaelis, M, Haferkamp, A, Jüngel, E, and Tsaur, I
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Die erworbene Resistenz gegenüber systemischen Therapeutika limitiert Behandlungsfortschritte bei Patienten mit metastasiertem Peniskarzinom (PeCa) erheblich. Da es sich bei PeCa um eine seltene Erkrankung handelt, ist die aktuelle Forschung bezüglich neuer vielversprechender Ansätze[zum vollständigen Text gelangen Sie über die oben angegebene URL], 61. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V.
- Published
- 2021
- Full Text
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42. Artesunate inhibits the progressive growth behavior of docetaxel-resistant prostate cancer cells
- Author
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Jüngel, E., primary, Vakhrusheva, O., additional, Erb, H.H.H., additional, Braeunig, V., additional, Markowitsch, S.D., additional, Schupp, P., additional, Slade, K.S., additional, Thomas, A., additional, Tsaur, I., additional, Puhr, M., additional, Culig, Z., additional, Cinatl Jr., J., additional, Michaelis, M., additional, Efferth, T., additional, and Haferkamp, A., additional
- Published
- 2021
- Full Text
- View/download PDF
43. Friedrich Hofmann: 01.09.1949–02.09.2018
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Stößel, U., Michaelis, M., and Nübling, M.
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- 2018
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44. Thermochemical treatment of sewage sludge ashes for phosphorus recovery
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Adam, C., Peplinski, B., Michaelis, M., Kley, G., and Simon, F.-G.
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- 2009
- Full Text
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45. Acid Phosphatase in Lens Epithelium of Rabbits after X-Irradiation
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Richards, R. D., Schocket, S. S., and Michaelis, M.
- Published
- 1969
- Full Text
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46. Patterns and mechanisms of resistance to cisplatin and osimertinib in penile squamous cell carcinoma
- Author
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Thomas, A., primary, Vakhrusheva, O., additional, Michaelis, M., additional, Cinatl, J., additional, Rothweiler, F., additional, Albersen, M., additional, Haferkamp, A., additional, Juengel, E., additional, and Tsaur, I., additional
- Published
- 2021
- Full Text
- View/download PDF
47. Das Wachstums- und Metastasierungsverhalten Docetaxel-resistenter Prostatakarzinomzellen wird durch Artesunat signifikant gehemmt
- Author
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Vakhrusheva, O, Erb, H, Bräunig, V, Stein, L, Wüstefeld, L, Slade, K, Culig, Z, Puhr, M, Michaelis, M, Cinatl, J, Efferth, T, Haferkamp, A, Jüngel, E, Vakhrusheva, O, Erb, H, Bräunig, V, Stein, L, Wüstefeld, L, Slade, K, Culig, Z, Puhr, M, Michaelis, M, Cinatl, J, Efferth, T, Haferkamp, A, and Jüngel, E
- Published
- 2021
48. mTOR/Akt-Signalweg-Proteine als potentielle Biomarker beim Peniskarzinom
- Author
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Thomas, A, Reetz, S, Stenzel, P, Tagscherer, K, Roth, W, Vakhrusheva, O, Macher-Göppinger, S, Michaelis, M, Rothweiler, F, Cinatl, J, Haferkamp, A, Jüngel, E, Tsaur, I, Thomas, A, Reetz, S, Stenzel, P, Tagscherer, K, Roth, W, Vakhrusheva, O, Macher-Göppinger, S, Michaelis, M, Rothweiler, F, Cinatl, J, Haferkamp, A, Jüngel, E, and Tsaur, I
- Published
- 2021
49. UP39 - mTOR/AKT pathway: New insights for dianostic and therapeutic care in penile cancer
- Author
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Vakhrusheva, O., Thomas, A., Huck, S., Slade, K., Michaelis, M., Cinatl, J., Rotweiler, F., Haferkamp, A., Juengel, E., Chinatl, J., and Tsaur, I.
- Published
- 2023
- Full Text
- View/download PDF
50. Alterations of the gene expression profile in renal cell carcinoma after treatment with the histone deacetylase-inhibitor valproic acid and interferon-alpha
- Author
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Juengel, E., Bhasin, M., Libermann, T., Barth, S., Michaelis, M., Cinatl, Jr, J., Jones, J., Hudak, L., Jonas, D., and Blaheta, R. A.
- Published
- 2011
- Full Text
- View/download PDF
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