1. Anxiety and Depression Associated With Increased Cardiovascular Disease Risk Through Accelerated Development of Risk Factors
- Author
-
Giovanni Civieri, MD, Shady Abohashem, MD, Simran S. Grewal, DO, Wesam Aldosoky, MD, Iqra Qamar, MD, Erin Hanlon, BS, Karmel W. Choi, PhD, Lisa M. Shin, PhD, Rachel P. Rosovsky, MD, MPH, Sandeep Chandra Bollepalli, PhD, Hui Chong Lau, Antonis Armoundas, PhD, Antonia V. Seligowski, PhD, Sarah M. Turgeon, PhD, Roger K. Pitman, MD, Francesco Tona, MD, PhD, Jason H. Wasfy, MD, MPhil, Jordan W. Smoller, MD, ScD, Sabino Iliceto, MD, Jill Goldstein, PhD, MPH, Catherine Gebhard, MD, PhD, Michael T. Osborne, MD, and Ahmed Tawakol, MD
- Subjects
amygdala ,cardiometabolic ,mental health ,neuro immune ,prevention ,sex differences ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Background: Prior studies have incompletely assessed whether the development of cardiometabolic risk factors (CVDRF) (hypertension, hyperlipidemia, and diabetes mellitus) mediates the association between anxiety and depression (anxiety/depression) and cardiovascular disease (CVD). Objectives: The authors aimed to evaluate the following: 1) the association between anxiety/depression and incident CVDRFs and whether this association mediates the increased CVD risk; and 2) whether neuro-immune mechanisms and age and sex effects may be involved. Methods: Using a retrospective cohort design, Mass General Brigham Biobank subjects were followed for 10 years. Presence and timing of anxiety/depression, CVDRFs, and CVD were determined using ICD codes. Stress-related neural activity, chronic inflammation, and autonomic function were measured by the assessment of amygdalar-to-cortical activity ratio, high-sensitivity CRP, and heart rate variability. Multivariable regression and mediation analyses were employed. Results: Among 71,214 subjects (median age 49.6 years; 55.3% female), 27,048 (38.0%) developed CVDRFs during follow-up. Pre-existing anxiety/depression associated with increased risk of incident CVDRF (OR: 1.71 [95% CI: 1.59-1.83], P
- Published
- 2024
- Full Text
- View/download PDF