1. Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance
- Author
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George F. Hoeferlin, Tejas Bajwa, Hannah Olivares, Jichu Zhang, Lindsey N. Druschel, Brandon S. Sturgill, Michael Sobota, Pierce Boucher, Jonathan Duncan, Ana G. Hernandez-Reynoso, Stuart F. Cogan, Joseph J. Pancrazio, and Jeffrey R. Capadona
- Subjects
intracortical microelectrode arrays ,neuroinflammation ,dimethyl fumarate ,antioxidant ,neural engineering ,brain-machine interface ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
Intracortical microelectrode arrays (MEAs) can be used in a range of applications, from basic neuroscience research to providing an intimate interface with the brain as part of a brain-computer interface (BCI) system aimed at restoring function for people living with neurological disorders or injuries. Unfortunately, MEAs tend to fail prematurely, leading to a loss in functionality for many applications. An important contributing factor in MEA failure is oxidative stress resulting from chronically inflammatory-activated microglia and macrophages releasing reactive oxygen species (ROS) around the implant site. Antioxidants offer a means for mitigating oxidative stress and improving tissue health and MEA performance. Here, we investigate using the clinically available antioxidant dimethyl fumarate (DMF) to reduce the neuroinflammatory response and improve MEA performance in a rat MEA model. Daily treatment of DMF for 16 weeks resulted in a significant improvement in the recording capabilities of MEA devices during the sub-chronic (Weeks 5–11) phase (42% active electrode yield vs. 35% for control). However, these sub-chronic improvements were lost in the chronic implantation phase, as a more exacerbated neuroinflammatory response occurs in DMF-treated animals by 16 weeks post-implantation. Yet, neuroinflammation was indiscriminate between treatment and control groups during the sub-chronic phase. Although worse for chronic use, a temporary improvement (
- Published
- 2023
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