Search

Both intravenous ondansetron (OND) and droperidol (DROP) have been observed to reduce vomiting after tonsillectomy in children. This randomized, double-blind investigation compared the effect of OND and DROP on vomiting after outpatient tonsillectomy in 276 healthy children age 2-12 yr. All subjects received a standardized anaesthetic, which consisted of induction with either propofol or halothane/N2O, vecuronium 0.1 mg x kg(-1) on an as needed basis, maintenance with halothane/N2O, midazolam and codeine, and reversal of neuromuscular blockade with neostigmine and atropine on an as needed basis. Subjects were given either OND 150 micrograms x kg(-1) or DROP 50 micrograms x kg(-1)iv after induction of anaesthesia. Rescue antiemetics in the hospital were administered to patients who vomited X 2 and X 4, respectively. Postoperative pain was treated with morphine, codeine and/or acetaminophen. For 24 hr following surgery, emesis was recorded by nursing staff while subjects were in the hospital, and by parents following discharge from hospital. The two groups were similar with respect to demographic data, induction technique and anaesthesia time. The frequency of in-hospital emesis was 16% in the OND-patients and 30% in the DROP-group, P

Vomiting is a common, unpleasant aftermath of tonsillectomy in children. Intraoperative intravenous ondansetron (OND) reduces vomiting after this operation. Our doubleblind, placebocontrolled, randomized investigation studied the effect of the oral form of OND on vomiting after outpatient tonsillectomy in children. We studied 233 healthy children age 2–14 yr undergoing elective tonsillectomy. Subjects were given placebo (PLAC) or OND 0.1 mg · kg−1 rounded off to the nearest 2 mg one hr before surgery. Anaesthesia was induced with either propofol or halothane/N2O. Vecuronium 0.1 mg · kg−1 was administered at the discretion of the anaesthetist. Anaesthesia was maintained with halothane/N2O, 50 μg · kg−1 midazolam iv and 1–1.5 mg · kg−1 codeine im. At the end of surgery, residual neuromuscular blockade was reversed with neostigmine and atropine. All episodes of inhospital emesis were recorded by nursing staff. Rescue antiemetics in the hospital were 1 mg · kg−1 dimenhydrinate ivfor vomiting × 2 and 50 μg · kg−1 droperidol iv for vomiting × 4. Parents kept a diary of emesis after discharge. Postoperative pain was treated with morphine, codeine and/or acetaminophen. The two groups were similar with respect to demographic data, induction technique and anaesthesia time. Oral OND (n = 109) reduced postoperative emesis from 54% to 39%, P < 0.05. This effect was most dramatic inhospital, where 10% of the OND-patients and 30% of the PLAC-group vomited, P < 0.05. The OND-subjects required fewer rescue antiemetics, 7% vs 17%, P < 0.05. In conclusion, oral ondansetron decreased the incidence of vomiting after outpatient tonsillectomy in children.

There is at present, very little information on congenital laryngomalacia in the anaesthetic literature. The purpose of this article is to review this topic, which in 90% of patients represents a benign self-limiting condition, disappearing by the age of two to five years. However, if untreated, the remaining 10% of cases can prove fatal. This severe form presents as persistent sternal recession, feeding difficulties, and failure to thrive, progressing to apnoeic attacks, cor pulmonale and eventually death. The developmental and functional anatomy of the larynx will be included, with a discussion of the pathophysiology and history of the disorder. Its diagnosis and a resume of the various treatment strategies, will be presented. The anaesthetic management is controversial as is the surgical technology. Our technique, for diagnosis or definitive repair, is based upon suspension laryngoscopy using topical local analgesia and spontaneous ventilation. Halothane is then administered by insufflation into the pharynx, using a #8 nasopharyngeal catheter, and suction is applied to the mouth. During the surgical repair, an endotracheal tube (ETT), may be inserted, at the discretion of the anaesthetist and surgeon. Finally, the role of the carbon dioxide CO2 laser and its hazards will be introduced.

After anesthesia employing nondepolarizing muscle relaxants, 30%-40% of adult patients demonstrate residual paralysis with a train-of-four ratio less than 70%, but it is not known if the same is true for children. This study was designed to investigate neuromuscular transmission in 91 ASA physical status I or II day-care children (aged 0-10 yr) after halothane anesthesia in which pancuronium (n = 34), atracurium (n = 32), or vecuronium (n = 25) was administered. Peripheral nerve stimulation was used clinically to assess neuromuscular blockade during surgery. In the recovery room, the evoked response of the adductor pollicis muscle was measured by train-of-four stimulation of the ulnar nerve. This measurement was made (mean +/- SEM) at 18.0 +/- 1.5, 15.0 +/- 1.3, and 15.0 +/- 1.7 min after pharmacologic antagonism with 0.02 mg/kg atropine and 0.06 mg/kg neostigmine in the pancuronium, atracurium, and vecuronium groups, respectively. There were no differences in the ages of the patients in the three groups at 4.3 +/- 0.4, 4.0 +/- 0.4, and 5.0 +/- 0.5 yr, with 17 children less than 2 yr. Recovery from neuromuscular blockade in all three groups was almost complete. The train-of-four ratio (height of fourth twitch compared with the first) was similar in patients who had received pancuronium (96.7% +/- 0.9%), atracurium (95.5% +/- 0.9%), or vecuronium (96.3% +/- 1.3%). Therefore, postoperative muscle weakness or respiratory impairment is unlikely in pediatric day-care surgical patients more than 2 yr old when these anesthetic techniques are used.

Characteristics of sickle ceil disease History Epidemiology and genetics Association with malaria Inheritance Clinical features Modifiers of clinical severity Pathophysiology Haemoglobinopathy Oxygen affinity Blood viscosity Cell membrane damage Micrncirculatory changes Molecular biology of sickle eelI anaemia Diagnosis Clinical examination Peripheral blood film and CBC Haemoglobin e]ectrophoresis I~rnergeney use of sodium metabisulphate preparation Neonatal diagnosis Prenatal diagnosis Treatment Supportive Specific therapies Augmentation of haemoglobin F Bone marrow transplantation Transfusion therapy Organization of Sickle Cell Centres in North America Management of general anaesthesia Preoperative considerations Technique of anaesthesia Sielde ceil crisis intraoperatively Controversies in anaesthetic management Preoperative use of blood transfusions The obstetric patient Neonates and infants The patient for open heart surgery