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130 results on '"Michael Mock"'

1. Integration of aeromedicine in the response to the COVID‐19 pandemic

Author

Lesley Osborn, David Meyer, Paul Dahm, Brandy Ferguson, Rodolfo Cabrera, Damon Sanger, Michael Mock, Tony Herrera, Shelby Mader, and Luis Ostrosky‐Zeichner

Subjects
aeromedicine, COVID‐19, decontamination, ECMO, EMS, HCID, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract There is limited guidance on the use of helicopter medical personnel to facilitate care of critically ill COVID‐19 patients. This manuscript describes the emergence of this novel virus, its mode of transmission, and the potential impacts on patient care in the unique environment of rotor wing aircraft. It details the development of clinical and operational guidelines for flight crew members. This allows other out‐of‐hospital clinicians to utilize our framework to augment or supplement their own for the current response effort to COVID‐19. It further serves as a road map for future response to the care of high consequence infectious disease patients.

Published
2020
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2. Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats

Author

Mohamed Ashmwe, Katja Posa, Alexander Rührnößl, Johannes Christoph Heinzel, Patrick Heimel, Michael Mock, Barbara Schädl, Claudia Keibl, Sebastien Couillard-Despres, Heinz Redl, Rainer Mittermayr, and David Hercher

Subjects
spinal cord injury, neuroregeneration, extracorporeal shockwave therapy, microRNAs, contusion injury, motor function, Biology (General), QH301-705.5
Abstract

Extracorporeal shockwave therapy (ESWT) can stimulate processes to promote regeneration, including cell proliferation and modulation of inflammation. Specific miRNA expression panels have been established to define correlations with regulatory targets within these pathways. This study aims to investigate the influence of low-energy ESWT—applied within the subacute and chronic phase of SCI (spinal cord injury) on recovery in a rat spinal cord contusion model. Outcomes were evaluated by gait analysis, µCT and histological analysis of spinal cords. A panel of serum-derived miRNAs after SCI and after ESWT was investigated to identify injury-, regeneration- and treatment-associated expression patterns. Rats receiving ESWT showed significant improvement in motor function in both a subacute and a chronic experimental setting. This effect was not reflected in changes in morphology, µCT-parameters or histological markers after ESWT. Expression analysis of various miRNAs, however, revealed changes after SCI and ESWT, with increased miR-375, indicating a neuroprotective effect, and decreased miR-382-5p potentially improving neuroplasticity via its regulatory involvement with BDNF. We were able to demonstrate a functional improvement of ESWT-treated animals after SCI in a subacute and chronic setting. Furthermore, the identification of miR-375 and miR-382-5p could potentially provide new targets for therapeutic intervention in future studies.

Published
2022
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20. Big Data Analytics for Time Critical Mobility Forecasting: Recent Progress and Research Challenges.

Author

George A. Vouros, Akrivi Vlachou, Georgios M. Santipantakis, Christos Doulkeridis, Nikos Pelekis, Harris V. Georgiou, Yannis Theodoridis, Kostas Patroumpas, Elias Alevizos, Alexander Artikis, Christophe Claramunt, Cyril Ray, David Scarlatti, Georg Fuchs, Gennady L. Andrienko, Natalia V. Andrienko, Michael Mock, Elena Camossi, Anne-Laure Jousselme, and Jose Manuel Cordero Garcia

Published
2018
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23. Inspect, Understand, Overcome: A Survey of Practical Methods for AI Safety.

Author

Sebastian Houben, Stephanie Abrecht, Maram Akila, Andreas Bär, Felix Brockherde, Patrick Feifel, Tim Fingscheidt, Sujan Sai Gannamaneni, Seyed Eghbal Ghobadi, Ahmed Hammam, Anselm Haselhoff, Felix Hauser, Christian Heinzemann, Marco Hoffmann, Nikhil Kapoor, Falk Kappel, Marvin Klingner, Jan Kronenberger, Fabian Küppers, Jonas Löhdefink, Michael Mlynarski, Michael Mock, Firas Mualla, Svetlana Pavlitskaya, Maximilian Poretschkin, Alexander Pohl, Varun Ravi Kumar, Julia Rosenzweig, Matthias Rottmann, Stefan Rüping 0001, Timo Sämann, Jan David Schneider, Elena Schulz, Gesina Schwalbe, Joachim Sicking, Toshika Srivastava, Serin Varghese, Michael Weber 0009, Sebastian Wirkert, Tim Wirtz, and Matthias Woehrle

Published
2021

48. Assurance Methodology for In-vehicle AI

Author

Frédérik Blank, Fabian Hüger, Michael Mock, Thomas Stauner, and Publica

Subjects
General Earth and Planetary Sciences, General Environmental Science
Abstract

The application of AI is a key enabler for highly automated driving. Initiated by VDA, a consortium of OEMs, suppliers, technology providers and scientific institutions is developing a methodology for a novel safety argumentation in the project “KI Absicherung” (safe AI) that systematically identifies insufficiencies of AI-based functions, makes them measurable and mitigates them. The project stems from the “VDA-Leitinitiative” (flagship initiative). An industrial consensus for a methodical approach is to be achieved which is demonstrated using the example of pedestrian detection.

Published
2022

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