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1. Systematic and other reviews: criteria and complexities

Author

Robert T. Sataloff, Matthew L. Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W. Fisher, David Goldenberg, Ehab Y. Hanna, Joseph E. Kerschner, Dennis H. Kraus, John H. Krouse, Daqing Li, Michael Link, Lawrence R. Lustig, Samuel H. Selesnick, Raj Sindwani, Richard J. Smith, James Tysome, Peter C. Weber, and D. Bradley Welling

Subjects
Surgery, RD1-811
Published
2021
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2. 29 Molecular markers predict long-term recurrence following resection of clival and spinal chordomas: A multi-center study

Author

Oluwaseun Akinduro, Yohan Alexander, Antonio Bon Nieves, Karim Nathani, Peter Rose, Michael Link, Jamie Van Gompel, Bernard Bendok, Carlos Pinheiro-Neto, Alfredo Quinones-Hinojosa, and Mohamad Bydon

Subjects
Medicine
Abstract

OBJECTIVES/GOALS: We aimed to find the histology-specific markers that were predictive of post-operative long-term chordoma recurrence (≤1 year) using trained multiple tree-based machine learning (ML) algorithms. METHODS/STUDY POPULATION: We reviewed the records of patients who had treatment for clival and spinal chordomas between January 2017 and June 2021 across the Mayo Clinic enterprise (Minnesota, Florida, and Arizona). Patients were excluded if they had no histopathology or recurrence as an outcome. Demographics, type of treatment, clinical and radiological follow-up duration, histopathology, and other relevant clinical factors were abstracted from each patient record. Decision tree and random forest classifiers were trained and tested to predict the long-term recurrence based on unseen data using an 80/20 split. The performance of the model was optimized using tenfold cross-validation. RESULTS/ANTICIPATED RESULTS: One hundred fifty-one patients were identified: 58 chordomas from the clivus, 48 chordomas of the mobile spine, and 45 sacrococcygeal. Subtotal Resection followed by radiation therapy, was the most common treatment modality, followed by Gross Total resection, then radiation therapy. The multivariate analysis defines the molecular predictors of recurrence following resection. S100 and pan-cytokeratin is more likely to increase the risk of post-operative recurrence (OR= 3.67; CI= [1.09,12.42], p=0.03). In the decision tree analysis, a clinical follow-up > 1897 days was found in 37 % of encounters and a 90% chance of being classified for recurrence (Accuracy= 77%). Factors predicting long-term recurrence are the patient’s age, type of surgical treatment, location of the tumor, S100, pan-cytokeratin, and EMA. DISCUSSION/SIGNIFICANCE: Our molecular and clinicopathological variables combined with tree-based ML tools successfully demonstrate a high capacity to individually identify the patient’s recurrence pattern with an accuracy of 77%. S100, pan-cytokeratin, and EMA were the histologic drivers of recurrence.

Published
2023
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3. Open Access: Is There a Predator at the Door?

Author

Rakesh Chandra MD, Edward W. Fisher MA, DM (Oxon), FRCS, Terry M. Jones BSc(Hons), MBBS, FRCSEd, FRCS(ORL-HNS), MD, David W. Kennedy MD, Dennis H. Kraus MD, FACS, John H. Krouse MD, PhD, MBA, Michael Link MD, Lawrence R. Lustig MD, Bert W. O’Malley MD, Jay F. Piccirillo MD, FACS, Robert Ruben MD, FAAP, FACS, Robert T. Sataloff MD, DMA, FACS, Raj Sindwani MD, Richard J. Smith MD, Michael G. Stewart MD, MPH, FACS, Peter C. Weber MD, D. Bradley Welling M.D., Ph.D., FACS, and Robin Youngs MB BS MD FRCS

Subjects
Otorhinolaryngology, RF1-547, Surgery, RD1-811
Published
2018
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4. Tracking Chronic Disease and Risk Behavior Prevalence as Survey Participation Declines: Statistics From the Behavioral Risk Factor Surveillance System and Other National Surveys

Author

Paul Levy, PhD, Ali Mokdad, PhD, Michael Link, PhD, Deborah A. Schwartz, and Mansour Fahimi, PhD

Subjects
chronic disease, BRFSS, tracking chronic disease, Public aspects of medicine, RA1-1270
Abstract

IntroductionResponse rates for the Behavioral Risk Factor Surveillance System (BRFSS) have declined in recent years. The response rate in 1993 was approximately 72%; in 2006, the response rate was approximately 51%. To assess the impact of this decline on the quality of BRFSS estimates, we compared selected health and risk factor estimates from BRFSS with similar estimates from the National Health Interview Survey (NHIS) and the National Health and Nutrition Examination Survey (NHANES).MethodsWe reviewed questionnaires from the 3 surveys and identified a set of comparable measures related to smoking prevalence, alcohol consumption, medical conditions, vaccination, health status, insurance coverage, cost barriers to medical care, testing for human immunodeficiency virus, and body measurements (height and weight).We compared weighted estimates for up to 15 outcome measures, including overall measures and measures for 12 population subgroups. We produced design-appropriate point estimates and carried out statistical tests of hypotheses on the equality of such estimates. We then calculated P values for comparisons of NHIS and NHANES estimates with their BRFSS counterparts.ResultsAlthough BRFSS and NHIS estimates were statistically similar for 5 of the 15 measures examined, BRFSS and NHANES estimates were statistically similar for only 1 of 6 measures. The observed differences for some of these comparisons were small, however.ConclusionThese surveys produced similar estimates for several outcome measures, although we observed significant differences as well. Many of the observed differences may have limited consequences for implementing related public health programs; other differences may require more detailed examination. In general, the range of BRFSS estimates examined here tends to parallel those from NHIS and NHANES, both of which have higher rates of participation.

Published
2008

7. Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis

Author

Scott R. Plotkin, Ludwine Messiaen, Eric Legius, Patrice Pancza, Robert A. Avery, Jaishri O. Blakeley, Dusica Babovic-Vuksanovic, Rosalie Ferner, Michael J. Fisher, Jan M. Friedman, Marco Giovannini, David H. Gutmann, Clemens Oliver Hanemann, Michel Kalamarides, Hildegard Kehrer-Sawatzki, Bruce R. Korf, Victor-Felix Mautner, Mia MacCollin, Laura Papi, Katherine A. Rauen, Vincent Riccardi, Elizabeth Schorry, Miriam J. Smith, Anat Stemmer-Rachamimov, David A. Stevenson, Nicole J. Ullrich, David Viskochil, Katharina Wimmer, Kaleb Yohay, Susan M. Huson, Pierre Wolkenstein, D. Gareth Evans, Monique Anten, Arthur Aylsworth, Diana Baralle, Sebastien Barbarot, Fred Barker, Shay Ben-Shachar, Amanda Bergner, Didier Bessis, Ignacio Blanco, Catherine Cassiman, Patricia Ciavarelli, Maurizio Clementi, Thierry Frébourg, Alicia Gomes, Dorothy Halliday, Chris Hammond Helen Hanson Arvid Heiberg, Pascal Joly, Justin T. Jordan, Matthias Karajannis, Daniela Kroshinsky, Margarita Larralde, Conxi Lázaro, Lu Le, Michael Link, Robert Listernick, Conor Mallucci, Vanessa L. Merker, Christopher Moertel, Amy Mueller, Joanne Ngeow, Rianne Oostenbrink, Roger Packer, Allyson Parry, Juha Peltonen, Dominique Pichard, Bruce Poppe, Nilton Rezende, Luiz Oswaldo Rodrigues, Tena Rosser, Martino Ruggieri, Eduard Serra, Verena Steinke-Lange, Stavros Michael Stivaros, Amy Taylor, Jaan Toelen, James Tonsgard, Eva Trevisson, Meena Upadhyaya, Ali Varan, Meredith Wilson, Hao Wu, Gelareh Zadeh, and Pediatrics

Subjects
Neurofibromatosis 2, Consensus, Neurofibromatosis 1, Skin Neoplasms, Neurofibromatoses, NF2, Neurofibromatosis, SMARCB1, Schwannomatosis, lztr1, Humans, Genetics (clinical), Neurilemmoma
Abstract

PURPOSE: Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are genetically distinct tumor predisposition syndromes with overlapping phenotypes. We sought to update the diagnostic criteria for NF2 and SWN by incorporating recent advances in genetics, ophthalmology, neuropathology, and neuroimaging. METHODS: We used a multistep process, beginning with a Delphi method involving global disease experts and subsequently involving non-neurofibromatosis clinical experts, patients, and foundations/patient advocacy groups. RESULTS: We reached consensus on the minimal clinical and genetic criteria for diagnosing NF2 and SWN. These criteria incorporate mosaic forms of these conditions. In addition, we recommend updated nomenclature for these disorders to emphasize their phenotypic overlap and to minimize misdiagnosis with neurofibromatosis type 1. CONCLUSION: The updated criteria for NF2 and SWN incorporate clinical features and genetic testing, with a focus on using molecular data to differentiate the 2 conditions. It is likely that continued refinement of these new criteria will be necessary as investigators study the diagnostic properties of the revised criteria and identify new genes associated with SWN. In the revised nomenclature, the term "neurofibromatosis 2" has been retired to improve diagnostic specificity. ispartof: GENETICS IN MEDICINE vol:24 issue:9 pages:1967-1977 ispartof: location:United States status: published

Published
2022

8. Protecting the integrity of survey research

Author

Kathleen Hall Jamieson, Arthur Lupia, Ashley Amaya, Henry E Brady, René Bautista, Joshua D Clinton, Jill A Dever, David Dutwin, Daniel L Goroff, D Sunshine Hillygus, Courtney Kennedy, Gary Langer, John S Lapinski, Michael Link, Tasha Philpot, Ken Prewitt, Doug Rivers, Lynn Vavreck, David C Wilson, and Marcia K McNutt

Abstract

Although polling is not irredeemably broken, changes in technology and society create challenges that, if not addressed well, can threaten the quality of election polls and other important surveys on topics such as the economy. This essay describes some of these challenges and recommends remediations to protect the integrity of all kinds of survey research, including election polls. These 12 recommendations specify ways that survey researchers, and those who use polls and other public-oriented surveys, can increase the accuracy and trustworthiness of their data and analyses. Many of these recommendations align practice with the scientific norms of transparency, clarity, and self-correction. The transparency recommendations focus on improving disclosure of factors that affect the nature and quality of survey data. The clarity recommendations call for more precise use of terms such as “representative sample” and clear description of survey attributes that can affect accuracy. The recommendation about correcting the record urges the creation of a publicly available, professionally curated archive of identified technical problems and their remedies. The paper also calls for development of better benchmarks and for additional research on the effects of panel conditioning. Finally, the authors suggest ways to help people who want to use or learn from survey research understand the strengths and limitations of surveys and distinguish legitimate and problematic uses of these methods.

Published
2023

14. Technikfolgenabschätzung in Energielandschaften

Author

Jürgen Scheffran, P. Michael Link, Mostafa Shaaban, Diana Süsser, and Jinxi Yang

Subjects
Social sciences (General), H1-99, Technology (General), T1-995
Abstract

Verglichen mit den Risiken und Konflikten des fossil-nuklearen Zeitalters erscheinen die erneuerbaren Energien in einem überwiegend positiven Licht. Allerdings schafft die Transformation zu einer kohlenstoffarmen Energieversorgung neue Energielandschaften, die einen hohen Bedarf an Landflächen mit sich bringen – was ebenfalls Energiekonflikte provozieren kann. Um derartige Konflikte zu mindern und die Akzeptanz der Bevölkerung zu gewinnen, kann Technikfolgenabschätzung einen Beitrag leisten, wenn sie sich auf räumliche agentenbasierte Modelle stützt. Diese Modelle repräsentieren die Entscheidungen von Stakeholdern über Energiealternativen, deren dynamische Interaktionen sowie daraus resultierende Landnutzungsoptionen und Energiepfade. Als Fallstudie dient Norddeutschland, wo Landwirte und Gemeinden als lokale Akteure der Energiewende agieren.

Published
2017
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19. From hermit crabs to humus: Heesoon Bai’s contributions to cultural studies in science education

Author

Hartley Banack, Steven Zhao, Michael Link, Allen Yee, Marcia McKenzie, Tom Culham, Charles Scott, Louise St. Pierre, Lee Beavington, David Chang, and Thomas Falkenberg

Subjects
Cultural Studies, Instrumental and intrinsic value, Contemplation, Aesthetics, media_common.quotation_subject, Dualism, Cultural studies, Subject (philosophy), Sociology, Sociology of Education, Science education, Object (philosophy), media_common
Abstract

This paper traces Heesoon Bai’s contributions to science education. Over the course of her career, Heesoon has written many scholarly articles that explore the foundational theories relevant to the culture of science education. Drawing from Eastern contemplative traditions, Heesoon aims to repair the separation between subject and object, a dualism that often operates in Western Science. She enjoins an animistic view of the world, where all things are alive and imbued with intrinsic value, and presents a view of education characterized by relational warmth and care. The essay is a compilation of testimonies from students who have worked with Heesoon Bai in the past. We present these accounts as a tribute to an outstanding educator who has made a positive contribution both in the field of science education and to the lives of many students.

Published
2021

21. PATH-34. SOLITARY FIBROUS TUMOR: NATURAL HISTORY AND PROGNOSIS IN ACCORDANCE WITH THE WHO 2021 CLASSIFICATION OF CNS TUMORS

Author

Kathryn Eschbacher, Sarah Jenkins, Karen Fritchie, Evgeny Moskalev, Alissa Caron, Michael Link, Paul Brown, Andrew Guajardo, Daniel Brat, Ashely Wu, Sandro Santagata, David Louis, Priscilla Brastianos, Alexander Kaplan, Brian Alexander, Sabrina Rossi, Fabio Ferrarese, David Raleigh, Minh Nguyen, John Gross, Jose Velazquez Vega, Fausto Rodriguez, Arie Perry, Maria Martinez-Lage Alverez, Florian Haller, and Caterina Giannini

Subjects
Cancer Research, Oncology, Neurology (clinical)
Abstract

Meningeal solitary fibrous tumor (SFT) is a rare tumor with high propensity to recur and metastasize, even late in the course of disease. The WHO 2021 classification of CNS tumors divides SFT in 3 grades, based on mitotic index and necrosis. We re-examined our cohort of 126 patients (57 F, 69 M; mean age 53.0 years) with SFT, confirmed by STAT6 nuclear positivity and/or NAB2::STAT6 fusion, with extended follow-up (median 7.6 years; range 4 days-26.6 years). Tumors included 76 grade 1, 36 grade 2 and 14 grade 3 according to 2021 WHO criteria, evaluated at primary resection (n=90), recurrence (n=35), or metastasis (n=1). Fifty-six patients had one or more post-surgical events, the earliest event being local recurrence (n=41) or metastasis (n=15). Forty patients died (29 of disease; 9 of other causes; 2 unknown). Overall survival (OS), and progression-free survival (PFS, recurrence and/or metastasis) from time of primary resection (n=90) were not significantly associated with grade; however, risk of metastasis differed significantly (5-year estimates: 4.1%, 15.3%, and 37.8% for grades 1, 2, and 3 SFT, respectively; p=0.005). NAB2::STAT6 fusion status was known in 101 cases (51 = ex5-7-ex16-17, 26 = ex4_ex2-3; 12 = ex2-3_exANY/other and 12 =no fusion). Disease specific 5-year survival in primary tumors with molecular data (n = 75) was 80.0% in patients whose tumors harbored ex5-7_ex16-17 compared to 93.3% in all others combined (p=0.014). Targeted TERT promoter mutation testing was performed in 98 patients, revealing patients with tumors lacking TERT promoter mutation (n = 88) were younger at time of surgery than those harboring a mutation (n=10; p = 0.022), and none with a mutation harboring concurrent ex5-7_ex16-17 fusion (p = 0.0009). In summary, WHO 2021 grade is associated with risk of metastasis. Patients whose tumors harbor ex5-7_ex16-17 fusion have a higher risk of dying from the disease.

Published
2022

26. [Systematic and other reviews: criteria and complexities]

Author

Y X, Sataloff, Matthew L, Bush, Rakesh, Chandra, Douglas, Chepeha, Brian, Rotenberg, Edward W, Fisher, David, Goldenberg, Ehab Y, Hanna, Joseph E, Kerschner, Dennis H, Kraus, John H, Krouse, Daqing, Li, Michael, Link, Lawrence R, Lustig, Samuel H, Selesnick, Raj, Sindwani, Richard J, Smith, James R, Tysome, Peter C, Weber, D Bradley, Welling, Xinhao, Zhang, and Zheng, Liu

Published
2021

27. Single-fraction Stereotactic Radiosurgery for Atypical Meningiomas (WHO grade II): Treatment Results Based on a 25-year Experience

Author

Hasegawa, Hirotaka, primary, Vakharia, Kunal, additional, Michael, Link J, additional, Stafford, Scott L, additional, Brown, Paul D, additional, Parney, Ian F, additional, Burns, Terry C, additional, Yan, Elizabeth S, additional, Mahajan, Anita, additional, Laack, Nadia N, additional, and Pollock, Bruce E, additional

Published
2021
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28. The Simons Observatory Large Aperture Telescope Receiver

Author

Zhu, N, Bhandarkar, T, Coppi, G, Kofman, A, Orlowski-Scherer, J, Xu, Z, Adachi, S, Ade, P, Aiola, S, Austermann, J, Bazarko, A, Beall, J, Bhimani, S, Richard Bond, J, Chesmore, G, Choi, S, Connors, J, Cothard, N, Devlin, M, Dicker, S, Dober, B, Duell, C, Duff, S, Dünner, R, Fabbian, G, Galitzki, N, Gallardo, P, Golec, J, Haridas, S, Harrington, K, Healy, E, Patty Ho, S, Huber, Z, Hubmayr, J, Iuliano, J, Johnson, B, Keatin, B, Kiuchi, K, Koopman, B, Lashner, J, Lee, A, Li, Y, Limon, M, Link, M, J Lucas, T, Mccarrick, H, Moore, J, Nati, F, Newburgh, L, Niemack, M, Pierpaoli, E, Randall, M, Perez Sarmiento, K, Saunders, L, Seibert, J, Sierra, C, Sonka, R, Spisak, J, Sutariya, S, Tajima, O, Teply, G, Thornton, R, Tsan, T, Tucker, C, Ullom, J, Vavagiakis, E, Vissers, M, Walker, S, Westbrook, B, Wollack, E, Zannoni, M, Ningfeng Zhu, Tanay Bhandarkar, Gabriele Coppi, Anna M. Kofman, John L. Orlowski-Scherer, Zhilei Xu, Shunsuke Adachi, Peter Ade, Simone Aiola, Jason Austermann, Andrew O. Bazarko, James A. Beall, Sanah Bhimani, J. Richard Bond, Grace E. Chesmore, Steve K. Choi, Jake Connors, Nicholas F. Cothard, Mark Devlin, Simon Dicker, Bradley Dober, Cody J. Duell, Shannon M. Duff, Rolando Dünner, Giulio Fabbian, Nicholas Galitzki, Patricio A. Gallardo, Joseph E. Golec, Saianeesh K. Haridas, Kathleen Harrington, Erin Healy, Shuay-Pwu Patty Ho, Zachary B. Huber, Johannes Hubmayr, Jeffrey Iuliano, Bradley R. Johnson, Brian Keatin, Kenji Kiuchi, Brian J. Koopman, Jack Lashner, Adrian T. Lee, Yaqiong Li, Michele Limon, Michael Link, Tammy J Lucas, Heather McCarrick, Jenna Moore, Federico Nati, Laura B. Newburgh, Michael D. Niemack, Elena Pierpaoli, Michael J. Randall, Karen Perez Sarmiento, Lauren J. Saunders, Joseph Seibert, Carlos Sierra, Rita Sonka, Jacob Spisak, Shreya Sutariya, Osamu Tajima, Grant P. Teply, Robert J. Thornton, Tran Tsan, Carole Tucker, Joel Ullom, Eve M. Vavagiakis, Michael R. Vissers, Samantha Walker, Benjamin Westbrook, Edward J. Wollack, Mario Zannoni, Zhu, N, Bhandarkar, T, Coppi, G, Kofman, A, Orlowski-Scherer, J, Xu, Z, Adachi, S, Ade, P, Aiola, S, Austermann, J, Bazarko, A, Beall, J, Bhimani, S, Richard Bond, J, Chesmore, G, Choi, S, Connors, J, Cothard, N, Devlin, M, Dicker, S, Dober, B, Duell, C, Duff, S, Dünner, R, Fabbian, G, Galitzki, N, Gallardo, P, Golec, J, Haridas, S, Harrington, K, Healy, E, Patty Ho, S, Huber, Z, Hubmayr, J, Iuliano, J, Johnson, B, Keatin, B, Kiuchi, K, Koopman, B, Lashner, J, Lee, A, Li, Y, Limon, M, Link, M, J Lucas, T, Mccarrick, H, Moore, J, Nati, F, Newburgh, L, Niemack, M, Pierpaoli, E, Randall, M, Perez Sarmiento, K, Saunders, L, Seibert, J, Sierra, C, Sonka, R, Spisak, J, Sutariya, S, Tajima, O, Teply, G, Thornton, R, Tsan, T, Tucker, C, Ullom, J, Vavagiakis, E, Vissers, M, Walker, S, Westbrook, B, Wollack, E, Zannoni, M, Ningfeng Zhu, Tanay Bhandarkar, Gabriele Coppi, Anna M. Kofman, John L. Orlowski-Scherer, Zhilei Xu, Shunsuke Adachi, Peter Ade, Simone Aiola, Jason Austermann, Andrew O. Bazarko, James A. Beall, Sanah Bhimani, J. Richard Bond, Grace E. Chesmore, Steve K. Choi, Jake Connors, Nicholas F. Cothard, Mark Devlin, Simon Dicker, Bradley Dober, Cody J. Duell, Shannon M. Duff, Rolando Dünner, Giulio Fabbian, Nicholas Galitzki, Patricio A. Gallardo, Joseph E. Golec, Saianeesh K. Haridas, Kathleen Harrington, Erin Healy, Shuay-Pwu Patty Ho, Zachary B. Huber, Johannes Hubmayr, Jeffrey Iuliano, Bradley R. Johnson, Brian Keatin, Kenji Kiuchi, Brian J. Koopman, Jack Lashner, Adrian T. Lee, Yaqiong Li, Michele Limon, Michael Link, Tammy J Lucas, Heather McCarrick, Jenna Moore, Federico Nati, Laura B. Newburgh, Michael D. Niemack, Elena Pierpaoli, Michael J. Randall, Karen Perez Sarmiento, Lauren J. Saunders, Joseph Seibert, Carlos Sierra, Rita Sonka, Jacob Spisak, Shreya Sutariya, Osamu Tajima, Grant P. Teply, Robert J. Thornton, Tran Tsan, Carole Tucker, Joel Ullom, Eve M. Vavagiakis, Michael R. Vissers, Samantha Walker, Benjamin Westbrook, Edward J. Wollack, and Mario Zannoni

Abstract

The Simons Observatory is a ground-based cosmic microwave background experiment that consists of three 0.4 m small-aperture telescopes and one 6 m Large Aperture Telescope, located at an elevation of 5300 m on Cerro Toco in Chile. The Simons Observatory Large Aperture Telescope Receiver (LATR) is the cryogenic camera that will be coupled to the Large Aperture Telescope. The resulting instrument will produce arcminute-resolution millimeter-wave maps of half the sky with unprecedented precision. The LATR is the largest cryogenic millimeter-wave camera built to date, with a diameter of 2.4 m and a length of 2.6 m. The coldest stage of the camera is cooled to 100 mK, the operating temperature of the bolometric detectors with bands centered around 27, 39, 93, 145, 225, and 280 GHz. Ultimately, the LATR will accommodate 13 40 cm diameter optics tubes, each with three detector wafers and a total of 62,000 detectors. The LATR design must simultaneously maintain the optical alignment of the system, control stray light, provide cryogenic isolation, limit thermal gradients, and minimize the time to cool the system from room temperature to 100 mK. The interplay between these competing factors poses unique challenges. We discuss the trade studies involved with the design, the final optimization, the construction, and ultimate performance of the system.

Published
2021

29. Design and Evaluation of a Simple Data Interface for Efficient Data Transfer Across Diverse Storage

Author

Rajkumar Kettimuthu, Michael Link, Joaquin Chung, Zhengchun Liu, Rachana Ananthakrishnan, and Ian Foster

Subjects
FOS: Computer and information sciences, Service (systems architecture), Computer Networks and Communications, Computer science, Distributed computing, Cloud computing, 02 engineering and technology, 01 natural sciences, 010305 fluids & plasmas, 0103 physical sciences, Distributed data store, 0202 electrical engineering, electronic engineering, information engineering, Media Technology, Computer Science (miscellaneous), Safety, Risk, Reliability and Quality, Abstraction (linguistics), 020203 distributed computing, business.industry, Data access, Computer Science - Distributed, Parallel, and Cluster Computing, Hardware and Architecture, Data exchange, Computer data storage, Distributed, Parallel, and Cluster Computing (cs.DC), business, Cloud storage, Software, Information Systems
Abstract

Modern science and engineering computing environments often feature storage systems of different types, from parallel file systems in high-performance computing centers to object stores operated by cloud providers. To enable easy, reliable, secure, and performant data exchange among these different systems, we propose Connector, a plug-able data access architecture for diverse, distributed storage. By abstracting low-level storage system details, this abstraction permits a managed data transfer service (Globus, in our case) to interact with a large and easily extended set of storage systems. Equally important, it supports third-party transfers: that is, direct data transfers from source to destination that are initiated by a third-party client but do not engage that third party in the data path. The abstraction also enables management of transfers for performance optimization, error handling, and end-to-end integrity. We present the Connector design, describe implementations for different storage services, evaluate tradeoffs inherent in managed vs. direct transfers, motivate recommended deployment options, and propose a model-based method that allows for easy characterization of performance in different contexts without exhaustive benchmarking.

Published
2020
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30. MSSP Special Issue devoted to Prof. Lothar Gaul

Author

Michael Link, Daniel J. Rixen, Kai Willner, and André Schmidt

Subjects
Control and Systems Engineering, Mechanical Engineering, Signal Processing, Aerospace Engineering, Computer Science Applications, Civil and Structural Engineering
Published
2022

31. New data strategies: nonprobability sampling, mobile, big data

Author

Michael Link

Subjects
Data collection, business.industry, Computer science, 05 social sciences, Automatic identification and data capture, Big data, Timeline, 01 natural sciences, Data science, 0506 political science, Education, Nonprobability sampling, 010104 statistics & probability, Resource (project management), 050602 political science & public administration, The Internet, Mobile technology, 0101 mathematics, business
Abstract

Purpose Researchers now have more ways than ever before to capture information about groups of interest. In many areas, these are augmenting traditional survey approaches – in others, new methods are potential replacements. This paper aims to explore three key trends: use of nonprobability samples, mobile data collection and administrative and “big data.” Design/methodology/approach Insights and lessons learned about these emerging trends are drawn from recent published articles and relevant scientific conference papers. Findings Each new trend has its own timeline in terms of methodological maturity. While mobile technologies for data capture are being rapidly adopted, particularly the use of internet-based surveys conducted on mobile devices, nonprobability sampling methods remain rare in most government research. Resource and quality pressures combined with the intensive research focus on new sampling methods, are, however, making nonprobability sampling a more attractive option. Finally, exploration of “big data” is becoming more common, although there are still many challenges to overcome – methodological, quality and access – before such data are used routinely. Originality/value This paper provides a timely review of recent developments in the field of data collection strategies, drawing on numerous current studies and practical applications in the field.

Published
2018

32. Energy Landscapes: Modeling of Renewable Energy Resources with an Emphasis on Northern Germany

Author

Hermann Held, P. Michael Link, Jürgen Scheffran, and Jürgen Böhner

Subjects
021110 strategic, defence & security studies, Atmospheric Science, Natural resource economics, business.industry, 05 social sciences, 050602 political science & public administration, 0211 other engineering and technologies, 02 engineering and technology, Business, Energy (signal processing), 0506 political science, Renewable energy
Published
2018

34. Erratum: 'The Simons Observatory Large Aperture Telescope Receiver' (2021, ApJS, 256, 23)

Author

Ningfeng Zhu, Tanay Bhandarkar, Gabriele Coppi, Anna M. Kofman, John L. Orlowski-Scherer, Zhilei Xu, Shunsuke Adachi, Peter Ade, Simone Aiola, Jason Austermann, Andrew O. Bazarko, James A. Beall, Sanah Bhimani, J. Richard Bond, Grace E. Chesmore, Steve K. Choi, Jake Connors, Nicholas F. Cothard, Mark Devlin, Simon Dicker, Bradley Dober, Cody J. Duell, Shannon M. Duff, Rolando Dünner, Giulio Fabbian, Nicholas Galitzki, Patricio A. Gallardo, Joseph E. Golec, Saianeesh K. Haridas, Kathleen Harrington, Erin Healy, Shuay-Pwu Patty Ho, Zachary B. Huber, Johannes Hubmayr, Jeffrey Iuliano, Bradley R. Johnson, Brian Keating, Kenji Kiuchi, Brian J. Koopman, Jack Lashner, Adrian T. Lee, Yaqiong Li, Michele Limon, Michael Link, Tammy J Lucas, Heather McCarrick, Jenna Moore, Federico Nati, Laura B. Newburgh, Michael D. Niemack, Elena Pierpaoli, Michael J. Randall, Karen Perez Sarmiento, Lauren J. Saunders, Joseph Seibert, Carlos Sierra, Rita Sonka, Jacob Spisak, Shreya Sutariya, Osamu Tajima, Grant P. Teply, Robert J. Thornton, Tran Tsan, Carole Tucker, Joel Ullom, Eve M. Vavagiakis, Michael R. Vissers, Samantha Walker, Benjamin Westbrook, Edward J. Wollack, and Mario Zannoni

Subjects
Space and Planetary Science, Astronomy and Astrophysics
Published
2021

35. Coast to coast: current multidisciplinary research trends in German coastal and marine geography

Author

Leonard Borchert, Pina von Prondzinski, P. Michael Link, and Diana Süsser

Subjects
010504 meteorology & atmospheric sciences, Ecology, business.industry, Environmental resource management, 010501 environmental sciences, Oceanography, 01 natural sciences, language.human_language, Current (stream), German, Geography, Multidisciplinary approach, Nature Conservation, language, business, 0105 earth and related environmental sciences, Nature and Landscape Conservation
Published
2017

38. The Term ‘Non-financial Information’ – A Semantic Analysis of a Key Feature of Current and Future Corporate Reporting

Author

Axel Haller, Tobias Groß, and Michael Link

Subjects
Knowledge management, Computer science, business.industry, 05 social sciences, Accounting, 050201 accounting, Semantic theory of truth, Terminology, 0502 economics and business, media_common.cataloged_instance, Corporate social responsibility, Semantic analysis (knowledge representation), Language for specific purposes, Business and International Management, European union, Corporate communication, business, 050203 business & management, Finance, media_common, Meaning (linguistics)
Abstract

Accounting and corporate reporting can be seen as a language for specific purposes. Such a language requires the use of terms and concepts with a precise and commonly shared meaning to allow effective and efficient communication. We analyze the term ‘non-financial information’, which has become a part of mandatory corporate reporting within the European Union (EU) through recent regulatory actions. Our analysis is based on a survey of the theoretical and empirical literature, on the rational of semantic theory, as well as on a questionnaire survey. The clear finding is that, up to now, neither a common meaning nor a generally accepted definition of ‘non-financial information’ exists. We derive from the applied theoretical concepts that this situation negatively impacts the efficiency and effectiveness of corporate communication. Against this background we discuss several venues that might help to overcome this deficiency like issuing a mandatory guideline or changing the terminology.

Published
2017

39. Foraminifera from the Norian–Rhaetian reef carbonates of the Taurus Mountains (Saklıkent, Turkey)

Author

Baba Senowbari-Daryan and Michael Link

Subjects
0301 basic medicine, 010506 paleontology, geography, geography.geographical_feature_category, biology, Turkey, lcsh:QE1-996.5, Geology, Foraminifera, Taurus Mountains, biology.organism_classification, 01 natural sciences, Saklıkent, lcsh:Geology, 03 medical and health sciences, Paleontology, 030104 developmental biology, Oceanography, Upper Triassic, reef, Reef, 0105 earth and related environmental sciences
Abstract

Norian–Rhaetian reef carbonates are exposed in several localities in Taurus Mountains. They predominately contain hypercalcified sponges, followed by scleractinian corals and other less numerous organisms. A coherent Norian–Rhaetian reef structure is exposed near the small town of Saklıkent, west of Antalya. Foraminifers occur in reef carbonates of Saklıkent by numerous genera as shown in this paper. Two species —Siculocosta tauricaandSiculocosta sadati— are described as new. The foraminiferal association of Saklıkent is similar or almost identical to the associations known from the Norian–Rhaetian reefs of Sicily, Northern Calcareous Alps, and Greece but shows less similarity to the foraminiferal association from the Apennines, Italy. The most abundant foraminifers are milioliporoids, particularly galeanellids and cucurbitids. Some sessile and agglutinated foraminifers, includingAlpinophragmium perforatumFlügel, which mostly occurs abundantly in the Norian–Rhaetian reef carbonates, could not be found in the Saklıkent reef. This association of foraminifera is reported for the first time from a Norian–Rhaetian reef in the Taurus Mountains of Turkey.

Published
2017

45. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Author

Hiddo J L Heerspink, Hans-Henrik Parving, Dennis L Andress, George Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, Dalane W Kitzman, Donald Kohan, Hirofumi Makino, John J V McMurray, Joel Z Melnick, Michael G Miller, Pablo E Pergola, Vlado Perkovic, Sheldon Tobe, Tingting Yi, Melissa Wigderson, Dick de Zeeuw, Alicia Elbert, Augusto Vallejos, Andres Alvarisqueta, Laura Maffei, Luis Juncos, Javier de Arteaga, Gustavo Greloni, Eduardo Farias, Alfredo Zucchini, Daniel Vogel, Ana Cusumano, Juan Santos, Margaret Fraenkel, Martin Gallagher, Tim Davis, Shamasunder Acharya, Duncan Cooke, Michael Suranyi, Simon Roger, Nigel Toussaint, Carol Pollock, Doris Chan, Stephen Stranks, Richard MacIsaac, Zoltan Endre, Alice Schmidt, Rudolf Prager, Gert Mayer, Xavier Warling, Michel Jadoul, Jean Hougardy, Chris Vercammen, Bruno Van Vlem, Pieter Gillard, Adriana Costa e Forti, Joao Lindolfo Borges, Luis Santos Canani, Freddy Eliaschewitz, Silmara Leite, Fadlo Fraige Filho, Raphael Paschoalin, Jose Andrade Moura Neto, Luciane Deboni, Irene de Lourdes Noronha, Cintia Cercato, Carlos Alberto Prompt, Maria Zanella, Nelson Rassi, Domingos D'Avila, Rosangela Milagres, Joao Felicio, Roberto Pecoits Filho, Miguel Carlos Riella, Joao Salles, Elizete Keitel, Sergio Draibe, Celso Amodeo, Joseph Youmbissi, Louise Roy, Serge Cournoyer, Shivinder Jolly, Vincent Pichette, Gihad Nesrallah, Harpreet Singh Bajaj, Hasnain Khandwala, Ronnie Aronson, Richard Goluch, Paul Tam, Christian Rabbat, Gordon Bailey, Stephen Chow, Alvaro Castillo, Alfredo Danin Vargas, Fernando Gonzalez, Rodrigo Munoz, Vicente Gutierrez, Gonzalo Godoy, Hongwen Zhao, Zhangsuo Liu, Minghui Zhao, Xiaohui Guo, Benli Su, Shuxia Fu, Yan Xu, Jinkui Yang, Bingyin Shi, Guanqing Xiao, Wei Shi, Chuanming Hao, Changying Xing, Fanfan Hou, Qun Luo, Yuxiu Li, Linong Ji, Li Zuo, Song Wang, Zhaohui Ni, Guohua Ding, Nan Chen, Jiajun Zhao, Weiping Jia, Shengqiang Yu, Jian Weng, Gang Xu, Ping Fu, Shiren Sun, Bicheng Liu, Xiaoqiang Ding, Ivan Rychlik, Alexandra Oplustilova, Dagmar Bartaskova, Vaclava Honova, Hana Chmelickova, Martin Petr, Petr Bucek, Vladimir Tesar, Emil Zahumensky, Johan Povlsen, Kenneth Egstrup, Anna Oczachowska-Kulik, Peter Rossing, Jorma Lahtela, Jorma Strand, Ilkka Kantola, Catherine Petit, Christian Combe, Philippe Zaoui, Vincent Esnault, Pablo Urena Torres, Jean-Michel Halimi, Bertrand Dussol, Tasso Bieler, Klemens Budde, Frank Dellanna, Thomas Segiet, Christine Kosch, Hans Schmidt-Guertler, Isabelle Schenkenberger, Volker Vielhauer, Frank Pistrosch, Mark Alscher, Christoph Hasslacher, Christian Hugo, Anja Muehlfeld, Christoph Wanner, Ploumis Passadakis, Theofanis Apostolou, Nikolaos Tentolouris, Ioannis Stefanidis, Konstantinos Mavromatidis, Vasilios Liakopoulos, Dimitrios Goumenos, Konstantinos Siamopoulos, Vincent Yeung, Risa Ozaki, Samuel Fung, Kathryn Tan, Sydney Tang, Sing Leung Lui, Siu Fai Cheung, Seamus Sreenan, Joseph Eustace, Donal O'Shea, Peter Lavin, Austin Stack, Yoram Yagil, Julio Wainstein, Hilla Knobler, Josef Cohen, Irina Kenis, Deeb Daoud, Yosefa Bar-Dayan, Victor Frajewicki, Faiad Adawi, Loreto Gesualdo, Domenico Santoro, Francesco Marino, Andrea Galfre, Chiara Brunati, Piero Ruggenenti, Giuseppe Rombola, Giuseppe Pugliese, Maura Ravera, Fabio Malberti, Giuseppe Pontoriero, Teresa Rampino, Salvatore De Cosmo, Ciro Esposito, Felice Nappi, Cataldo Abaterusso, Giuseppe Conte, Vincenzo Panichi, Davide Lauro, Giovambattista Capasso, Domenico Russo, Jiichi Anzai, Motoji Naka, Keita Ato, Tetsuro Tsujimoto, Toshinori Nimura, Eitaro Nakashima, Tetsuro Takeda, Shinya Fujii, Kunihisa Kobayashi, Hideaki Iwaoka, Koji Nagayama, Hiroyuki Harada, Hajime Maeda, Rui Kishimoto, Tadashi Iitsuka, Naoki Itabashi, Ryuichi Furuya, Yoshitaka Maeda, Daishiro Yamada, Nobuhiro Sasaki, Hiromitsu Sasaki, Shinichiro Ueda, Naoki Kashihara, Shuichi Watanabe, Takehiro Nakamura, Hidetoshi Kanai, Yuichiro Makita, Keiko Ono, Noriyuki Iehara, Daisuke Goto, Keiichiro Kosuge, Kenichi Tsuchida, Toshiaki Sato, Takashi Sekikawa, Hideki Okamoto, Tsuyoshi Tanaka, Naoko Ikeda, Takenobu Tadika, Koji Mukasa, Takeshi Osonoi, Fuminori Hirano, Motonobu Nishimura, Yuko Yambe, Yukio Tanaka, Makoto Ujihara, Takashi Sakai, Mitsuo Imura, Yutaka Umayahara, Shinya Makino, Jun Nakazawa, Yukinari Yamaguchi, Susumu Kashine, Hiroaki Miyaoka, Katsunori Suzuki, Toshihiko Inoue, Sou Nagai, Nobuyuki Sato, Masahiro Yamamoto, Noriyasu Taya, Akira Fujita, Akira Matsutani, Yugo Shibagaki, Yuichi Sato, Akira Yamauchi, Masahiro Tsutsui, Tamayo Ishiko, Shizuka Kaneko, Nobuyuki Azuma, Hirofumi Matsuda, Yasuhiro Hashiguchi, Yukiko Onishi, Mikiya Tokui, Munehide Matsuhisa, Arihiro Kiyosue, Junji Shinoda, Kazuo Ishikawa, Ghazali Ahmad, Shalini Vijayasingham, Nor Azizah Aziz, Zanariah Hussein, Yin Khet Fung, Wan Hasnul Halimi Wan Hassan, Hin Seng Wong, Bak Leong Goh, Norhaliza Mohd Ali, Nor Shaffinaz Yusuf Azmi Merican, Indralingam Vaithilingam, Nik Nur Fatnoon Nik Ahmad, Noor Adam, Norlela Sukor, V Paranthaman P Vengadasalam, Khalid Abdul Kadir, Mafauzy Mohamed, Karina Renoirte Lopez, Aniceto Leguizamo-Dimas, Alfredo Chew Wong, Jose Chevaile-Ramos, Jose Gonzalez Gonzalez, Raul Rico Hernandez, Jose Nino-Cruz, Leobardo Sauque Reyna, Guillermo Gonzalez-Galvez, Magdalena Madero Rovalo, Tomasso Bochicchio-Ricardelli, Jorge Aldrete, Jaime Carranza-Madrigal, Liffert Vogt, Peter Smak Gregoor, JNM Barendregt, Peter Luik, Ronald Gansevoort, Gozewijn Laverman, Helen Pilmore, Helen Lunt, John Baker, Steven Miller, Kannaiyan Rabindranath, Luis Zapata-Rincon, Rolando Vargas-Gonzales, Jorge Calderon Ticona, Augusto Dextre Espinoza, Jose Burga Nunez, Carlos Antonio Zea-Nunez, Benjamin Herrada Orue, Boris Medina-Santander, Cesar Delgado-Butron, Julio Farfan-Aspilcueta, Stanislaw Mazur, Miroslaw Necki, Michal Wruk, Katarzyna Klodawska, Grazyna Popenda, Ewa Skokowska, Malgorzata Arciszewska, Andrzej Wiecek, Kazimierz Ciechanowski, Michal Nowicki, Rita Birne, Antonio Cabrita, Aura Ramos, Manuel Anibal Antunes Ferreira, Evelyn Matta Fontanet, Altagracia Aurora Alcantara-Gonzalez, Angel Comulada-Rivera, Eugenia Galindo Ramos, Jose Cangiano, Luis Quesada-Suarez, Ricardo Calderon Ortiz, Jose Vazquez-Tanus, Rafael Burgos-Calderon, Carlos Rosado, Nicolae Hancu, Ella Pintilei, Cristina Mistodie, Gabriel Bako, Lavinia Ionutiu, Ligia Petrica, Romulus Timar, Liliana Tuta, Livia Duma, Adriana Tutescu, Svetlana Ivanova, Ashot Essaian, Konstantin Zrazhevskiy, Natalia Tomilina, Elena Smolyarchuk, Anatoly Kuzin, Olga Lantseva, Irina Karpova, Minara Shamkhalova, Natalia Liberanskaya, Andrey Yavdosyuk, Yuri Shvarts, Tatiana Bardymova, Olga Blagoveshchenskaya, Oleg Solovev, Elena Rechkova, Natalia Pikalova, Maria Pavlova, Elena Kolmakova, Rustam Sayfutdinov, Svetlana Villevalde, Natalya Koziolova, Vladimir Martynenko, Vyacheslav Marasaev, Adelya Maksudova, Olga Sigitova, Viktor Mordovin, Vadim Klimontov, Yulia Samoylova, Tatiana Karonova, Lee Ying Yeoh, Boon Wee Teo, Marjorie Wai Yin Foo, Adrian Liew, Ivan Tkac, Aniko Oroszova, Jozef Fekete, Jaroslav Rosenberger, Ida Obetkova, Alla Fulopova, Eva Kolesarova, Katarina Raslova, Peter Smolko, Adrian Oksa, Larry Distiller, Julien Trokis, Luthando Adams, Hemant Makan, Padaruth Ramlachan, Essack Mitha, Kathleen Coetzee, Zelda Punt, Qasim Bhorat, Puvenesvari Naiker, Graham Ellis, Louis Van Zyl, Kwan Woo Lee, Min Seon Kim, Soon-Jib Yoo, Kun Ho Yoon, Yong-Wook Cho, Tae-Sun Park, Sang Yong Kim, Moon-Gi Choi, Tae Keun Oh, Kang-Wook Lee, Ho Sang Shon, Sung Hwan Suh, Byung-Joon Kim, Kim Doo-Man, Joo Hark Yi, Sang Ah Lee, Ho Chan Cho, Sin-Gon Kim, Dae-Ryong Cha, Ji A Seo, Kyung Mook Choi, Jeong-Taek Woo, Kyu Jeung Ahn, Jae Hyuk Lee, In-Joo Kim, Moon-Kyu Lee, Hak Chul Jang, Kyong-Soo Park, Beom Seok Kim, Ji Oh Mok, Mijung Shin, Sun Ae Yoon, Il-Seong Nam-Goong, Choon Hee Chung, Tae Yang Yu, Hyoung Woo Lee, Alfonso Soto Gonzalez, Jaume Almirall, Jesus Egido, Francesca Calero Gonzalez, Gema Fernandez Fresnedo, Ildefonso Valera Cortes, Manuel Praga Terente, Isabel Garcia Mendez, Juan Navarro Gonzalez, Jose Herrero Calvo, Secundino Cigarran Guldris, Mario Prieto Velasco, Jose Ignacio Minguela Pesquera, Antonio Galan, Julio Pascual, Maria Marques Vidas, Judith Martins Munoz, Jose Rodriguez-Perez, Cristina Castro-Alonso, Josep Bonet Sol, Daniel Seron, Elvira Fernandez Giraldez, Javier Arrieta Lezama, Nuria Montero, Julio Hernandez-Jaras, Rafael Santamaria Olmo, Jose Ramon Molas Coten, Olof Hellberg, Bengt Fellstrom, Andreas Bock, Dee Pei, Ching-Ling Lin, Kai-Jen Tien, Ching-Chu Chen, Chien-Ning Huang, Ju-Ying Jiang, Du-An Wu, Chih-Hsun Chu, Shih-Ting Tseng, Jung-Fu Chen, Cho-Tsan Bau, Wayne Sheu, Mai-Szu Wu, Ramazan Sari, Siren Sezer, Alaattin Yildiz, Ilhan Satman, Betul Kalender, Borys Mankovskyy, Ivan Fushtey, Mykola Stanislavchuk, Mykola Kolenyk, Iryna Dudar, Viktoriia Zolotaikina, Orest Abrahamovych, Tetyana Kostynenko, Olena Petrosyan, Petro Kuskalo, Olga Galushchak, Oleg Legun, Ivan Topchii, Liliya Martynyuk, Vasyl Stryzhak, Svitlana Panina, Sergii Tkach, Vadym Korpachev, Peter Maxwell, Luigi Gnudi, Sui Phin Kon, Hilary Tindall, Phillip Kalra, Patrick Mark, Dipesh Patel, Mohamed El-Shahawy, Liqun Bai, Romanita Nica, Yeong-Hau Lien, Judson Menefee, Robert Busch, Alan Miller, Azazuddin Ahmed, Ahmed Arif, Joseph Lee, Sachin Desai, Shweta Bansal, Marie Bentsianov, Mario Belledonne, Charles Jere, Raul Gaona, Gregory Greenwood, Osvaldo Brusco, Mark Boiskin, Diogo Belo, Raffi Minasian, Naveen Atray, Mary Lawrence, John Taliercio, Pablo Pergola, David Scott, German Alvarez, Bradley Marder, Thomas Powell, Wa'el Bakdash, George Stoica, Christopher McFadden, Marc Rendell, Jonathan Wise, Audrey Jones, Michael Jardula, Ivy-Joan Madu, Freemu Varghese, Brian Tulloch, Ziauddin Ahmed, Melanie Hames, Imran Nazeer, Newman Shahid, Rekha John, Manuel Montero, David Fitz-Patrick, Lawrence Phillips, Antonio Guasch, Elena Christofides, Aijaz Gundroo, Mohammad Amin, Cynthia Bowman-Stroud, Michael Link, Laura Mulloy, Michael Nammour, Tarik Lalwani, Lenita Hanson, Adam Whaley-Connell, Lee Herman, Rupi Chatha, Sayed Osama, Kenneth Liss, Zeid Kayali, Anuj Bhargava, Ezra Israel, Alfredo Peguero-Rivera, Michael Fang, Judith Slover, Elena Barengolts, Jose Flores, Rosemary Muoneke, Virginia Savin, Stella Awua-Larbi, Andrew Levine, George Newman, Laden Golestaneh, Guillermo Bohm, Efrain Reisin, Lucita Cruz, Robert Weiss, Franklin Zieve, Edward Horwitz, Peale Chuang, James Mersey, John Manley, Ronald Graf, Fadi Bedros, Sudhir Joshi, Juan Frias, Ali Assefi, Andrew O'Shaughnessy, Roman Brantley, Todd Minga, David Tietjen, Samuel Kantor, Aamir Jamal, Ramon Guadiz, Kenneth Hershon, Peter Bressler, Nelson Kopyt, Harold Cathcart, Scott Bloom, Ronald Reichel, Samer Nakhle, Emily Dulude, Joshua Tarkan, Penelope Baker, Steven Zeig, Jaynier Moya Hechevarria, Armando Ropero-Cartier, Gilda De la Calle, Ankur Doshi, Fadi Saba, Teresa Sligh, Sylvia Shaw, Jayant Kumar, Harold Szerlip, George Bayliss, Alan Perlman, Lakhi Sakhrani, Steven Gouge, Georges Argoud, Idalia Acosta, John Elder, Sucharit Joshi, John Sensenbrenner, Steven Vicks, Roberto Mangoo-Karim, Claude Galphin, Carlos Leon-Forero, John Gilbert, Eric Brown, Adeel Ijaz, Salman Butt, Mariana Markell, Carlos Arauz-Pacheco, Lance Sloan, Odilon Alvarado, Serge Jabbour, Eric Simon, Anjay Rastogi, Sam James, Karen Hall, John Melish, Brad Dixon, Allen Adolphe, Csaba Kovesdy, Srinivasan Beddhu, Richard Solomon, Ronald Fernando, Ellis Levin, Charuhas Thakar, Brooks Robey, David Goldfarb, Linda Fried, Geetha Maddukuri, Stephen Thomson, Andrew Annand, Saeed Kronfli, Paramjit Kalirao, Rebecca Schmidt, Neera Dahl, Samuel Blumenthal, Debra Weinstein, Ove Ostergaard, Talia Weinstein, Yasuhiro Ono, Murat Yalcin, Shahana Karim, APH - Health Behaviors & Chronic Diseases, Nephrology, ACS - Amsterdam Cardiovascular Sciences, ACS - Microcirculation, Biomedical Signals and Systems, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Groningen Kidney Center (GKC), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Heerspink, H. J. L., Parving, H. -H., Andress, D. L., Bakris, G., Correa-Rotter, R., Hou, F. -F., Kitzman, D. W., Kohan, D., Makino, H., Mcmurray, J. J. V., Melnick, J. Z., Miller, M. G., Pergola, P. E., Perkovic, V., Tobe, S., Yi, T., Wigderson, M., de Zeeuw, D., Elbert, A., Vallejos, A., Alvarisqueta, A., Maffei, L., Juncos, L., de Arteaga, J., Greloni, G., Farias, E., Zucchini, A., Vogel, D., Cusumano, A., Santos, J., Fraenkel, M., Gallagher, M., Davis, T., Acharya, S., Cooke, D., Suranyi, M., Roger, S., Toussaint, N., Pollock, C., Chan, D., Stranks, S., Macisaac, R., Endre, Z., Schmidt, A., Prager, R., Mayer, G., Warling, X., Jadoul, M., Hougardy, J., Vercammen, C., Van Vlem, B., Gillard, P., Costa e Forti, A., Borges, J. L., Santos Canani, L., Eliaschewitz, F., Leite, S., Fraige Filho, F., Paschoalin, R., Moura Neto, J. A., Deboni, L., de Lourdes Noronha, I., Cercato, C., Prompt, C. A., Zanella, M., Rassi, N., D'Avila, D., Milagres, R., Felicio, J., Pecoits Filho, R., Riella, M. C., Salles, J., Keitel, E., Draibe, S., Amodeo, C., Youmbissi, J., Roy, L., Cournoyer, S., Jolly, S., Pichette, V., Nesrallah, G., Bajaj, H. S., Khandwala, H., Aronson, R., Goluch, R., Tam, P., Rabbat, C., Bailey, G., Chow, S., Castillo, A., Danin Vargas, A., Gonzalez, F., Munoz, R., Gutierrez, V., Godoy, G., Zhao, H., Liu, Z., Zhao, M., Guo, X., Su, B., Fu, S., Xu, Y., Yang, J., Shi, B., Xiao, G., Shi, W., Hao, C., Xing, C., Hou, F., Luo, Q., Li, Y., Ji, L., Zuo, L., Wang, S., Ni, Z., Ding, G., Chen, N., Zhao, J., Jia, W., Yu, S., Weng, J., Xu, G., Fu, P., Sun, S., Liu, B., Ding, X., Rychlik, I., Oplustilova, A., Bartaskova, D., Honova, V., Chmelickova, H., Petr, M., Bucek, P., Tesar, V., Zahumensky, E., Povlsen, J., Egstrup, K., Oczachowska-Kulik, A., Rossing, P., Lahtela, J., Strand, J., Kantola, I., Petit, C., Combe, C., Zaoui, P., Esnault, V., Urena Torres, P., Halimi, J. -M., Dussol, B., Bieler, T., Budde, K., Dellanna, F., Segiet, T., Kosch, C., Schmidt-Guertler, H., Schenkenberger, I., Vielhauer, V., Pistrosch, F., Alscher, M., Hasslacher, C., Hugo, C., Muehlfeld, A., Wanner, C., Passadakis, P., Apostolou, T., Tentolouris, N., Stefanidis, I., Mavromatidis, K., Liakopoulos, V., Goumenos, D., Siamopoulos, K., Yeung, V., Ozaki, R., Fung, S., Tan, K., Tang, S., Lui, S. L., Cheung, S. F., Sreenan, S., Eustace, J., O'Shea, D., Lavin, P., Stack, A., Yagil, Y., Wainstein, J., Knobler, H., Cohen, J., Kenis, I., Daoud, D., Bar-Dayan, Y., Frajewicki, V., Adawi, F., Gesualdo, L., Santoro, D., Marino, F., Galfre, A., Brunati, C., Ruggenenti, P., Rombola, G., Pugliese, G., Ravera, M., Malberti, F., Pontoriero, G., Rampino, T., De Cosmo, S., Esposito, C., Nappi, F., Abaterusso, C., Conte, G., Panichi, V., Lauro, D., Capasso, G., Russo, D., Anzai, J., Naka, M., Ato, K., Tsujimoto, T., Nimura, T., Nakashima, E., Takeda, T., Fujii, S., Kobayashi, K., Iwaoka, H., Nagayama, K., Harada, H., Maeda, H., Kishimoto, R., Iitsuka, T., Itabashi, N., Furuya, R., Maeda, Y., Yamada, D., Sasaki, N., Sasaki, H., Ueda, S., Kashihara, N., Watanabe, S., Nakamura, T., Kanai, H., Makita, Y., Ono, K., Iehara, N., Goto, D., Kosuge, K., Tsuchida, K., Sato, T., Sekikawa, T., Okamoto, H., Tanaka, T., Ikeda, N., Tadika, T., Mukasa, K., Osonoi, T., Hirano, F., Nishimura, M., Yambe, Y., Tanaka, Y., Ujihara, M., Sakai, T., Imura, M., Umayahara, Y., Makino, S., Nakazawa, J., Yamaguchi, Y., Kashine, S., Miyaoka, H., Suzuki, K., Inoue, T., Nagai, S., Sato, N., Yamamoto, M., Taya, N., Fujita, A., Matsutani, A., Shibagaki, Y., Sato, Y., Yamauchi, A., Tsutsui, M., Ishiko, T., Kaneko, S., Azuma, N., Matsuda, H., Hashiguchi, Y., Onishi, Y., Tokui, M., Matsuhisa, M., Kiyosue, A., Shinoda, J., Ishikawa, K., Ahmad, G., Vijayasingham, S., Aziz, N. A., Hussein, Z., Fung, Y. K., Hassan, W. H. H. W., Wong, H. S., Goh, B. L., Ali, N. M., Merican, N. S. Y. A., Vaithilingam, I., Nik Ahmad, N. N. F., Adam, N., Sukor, N., Vengadasalam, V. P. P., Abdul Kadir, K., Mohamed, M., Renoirte Lopez, K., Leguizamo-Dimas, A., Chew Wong, A., Chevaile-Ramos, J., Gonzalez Gonzalez, J., Rico Hernandez, R., Nino-Cruz, J., Sauque Reyna, L., Gonzalez-Galvez, G., Madero Rovalo, M., Bochicchio-Ricardelli, T., Aldrete, J., Carranza-Madrigal, J., Vogt, L., Smak Gregoor, P., Barendregt, J. N. M., Luik, P., Gansevoort, R., Laverman, G., Pilmore, H., Lunt, H., Baker, J., Miller, S., Rabindranath, K., Zapata-Rincon, L., Vargas-Gonzales, R., Calderon Ticona, J., Dextre Espinoza, A., Burga Nunez, J., Zea-Nunez, C. A., Herrada Orue, B., Medina-Santander, B., Delgado-Butron, C., Farfan-Aspilcueta, J., Mazur, S., Necki, M., Wruk, M., Klodawska, K., Popenda, G., Skokowska, E., Arciszewska, M., Wiecek, A., Ciechanowski, K., Nowicki, M., Birne, R., Cabrita, A., Ramos, A., Antunes Ferreira, M. A., Matta Fontanet, E., Alcantara-Gonzalez, A. A., Comulada-Rivera, A., Galindo Ramos, E., Cangiano, J., Quesada-Suarez, L., Calderon Ortiz, R., Vazquez-Tanus, J., Burgos-Calderon, R., Rosado, C., Hancu, N., Pintilei, E., Mistodie, C., Bako, G., Ionutiu, L., Petrica, L., Timar, R., Tuta, L., Duma, L., Tutescu, A., Ivanova, S., Essaian, A., Zrazhevskiy, K., Tomilina, N., Smolyarchuk, E., Kuzin, A., Lantseva, O., Karpova, I., Shamkhalova, M., Liberanskaya, N., Yavdosyuk, A., Shvarts, Y., Bardymova, T., Blagoveshchenskaya, O., Solovev, O., Rechkova, E., Pikalova, N., Pavlova, M., Kolmakova, E., Sayfutdinov, R., Villevalde, S., Koziolova, N., Martynenko, V., Marasaev, V., Maksudova, A., Sigitova, O., Mordovin, V., Klimontov, V., Samoylova, Y., Karonova, T., Yeoh, L. Y., Teo, B. W., Foo, M. W. Y., Liew, A., Tkac, I., Oroszova, A., Fekete, J., Rosenberger, J., Obetkova, I., Fulopova, A., Kolesarova, E., Raslova, K., Smolko, P., Oksa, A., Distiller, L., Trokis, J., Adams, L., Makan, H., Ramlachan, P., Mitha, E., Coetzee, K., Punt, Z., Bhorat, Q., Naiker, P., Ellis, G., Van Zyl, L., Lee, K. W., Kim, M. S., Yoo, S. -J., Yoon, K. H., Cho, Y. -W., Park, T. -S., Kim, S. Y., Choi, M. -G., Oh, T. K., Lee, K. -W., Shon, H. S., Suh, S. H., Kim, B. -J., Doo-Man, K., Yi, J. H., Lee, S. A., Cho, H. C., Kim, S. -G., Cha, D. -R., Seo, J. A., Choi, K. M., Woo, J. -T., Ahn, K. J., Lee, J. H., Kim, I. -J., Lee, M. -K., Jang, H. C., Park, K. -S., Kim, B. S., Mok, J. O., Shin, M., Yoon, S. A., Nam-Goong, I. -S., Chung, C. H., Yu, T. Y., Lee, H. W., Soto Gonzalez, A., Almirall, J., Egido, J., Calero Gonzalez, F., Fernandez Fresnedo, G., Valera Cortes, I., Praga Terente, M., Garcia Mendez, I., Navarro Gonzalez, J., Herrero Calvo, J., Cigarran Guldris, S., Prieto Velasco, M., Minguela Pesquera, J. I., Galan, A., Pascual, J., Marques Vidas, M., Martins Munoz, J., Rodriguez-Perez, J., Castro-Alonso, C., Bonet Sol, J., Seron, D., Fernandez Giraldez, E., Arrieta Lezama, J., Montero, N., Hernandez-Jaras, J., Santamaria Olmo, R., Molas Coten, J. R., Hellberg, O., Fellstrom, B., Bock, A., Pei, D., Lin, C. -L., Tien, K. -J., Chen, C. -C., Huang, C. -N., Jiang, J. -Y., Wu, D. -A., Chu, C. -H., Tseng, S. -T., Chen, J. -F., Bau, C. -T., Sheu, W., Wu, M. -S., Sari, R., Sezer, S., Yildiz, A., Satman, I., Kalender, B., Mankovskyy, B., Fushtey, I., Stanislavchuk, M., Kolenyk, M., Dudar, I., Zolotaikina, V., Abrahamovych, O., Kostynenko, T., Petrosyan, O., Kuskalo, P., Galushchak, O., Legun, O., Topchii, I., Martynyuk, L., Stryzhak, V., Panina, S., Tkach, S., Korpachev, V., Maxwell, P., Gnudi, L., Kon, S. P., Tindall, H., Kalra, P., Mark, P., Patel, D., El-Shahawy, M., Bai, L., Nica, R., Lien, Y. -H., Menefee, J., Busch, R., Miller, A., Ahmed, A., Arif, A., Lee, J., Desai, S., Bansal, S., Bentsianov, M., Belledonne, M., Jere, C., Gaona, R., Greenwood, G., Brusco, O., Boiskin, M., Belo, D., Minasian, R., Atray, N., Lawrence, M., Taliercio, J., Pergola, P., Scott, D., Alvarez, G., Marder, B., Powell, T., Bakdash, W., Stoica, G., Mcfadden, C., Rendell, M., Wise, J., Jones, A., Jardula, M., Madu, I. -J., Varghese, F., Tulloch, B., Ahmed, Z., Hames, M., Nazeer, I., Shahid, N., John, R., Montero, M., Fitz-Patrick, D., Phillips, L., Guasch, A., Christofides, E., Gundroo, A., Amin, M., Bowman-Stroud, C., Link, M., Mulloy, L., Nammour, M., Lalwani, T., Hanson, L., Whaley-Connell, A., Herman, L., Chatha, R., Osama, S., Liss, K., Kayali, Z., Bhargava, A., Israel, E., Peguero-Rivera, A., Fang, M., Slover, J., Barengolts, E., Flores, J., Muoneke, R., Savin, V., Awua-Larbi, S., Levine, A., Newman, G., Golestaneh, L., Bohm, G., Reisin, E., Cruz, L., Weiss, R., Zieve, F., Horwitz, E., Chuang, P., Mersey, J., Manley, J., Graf, R., Bedros, F., Joshi, S., Frias, J., Assefi, A., O'Shaughnessy, A., Brantley, R., Minga, T., Tietjen, D., Kantor, S., Jamal, A., Guadiz, R., Hershon, K., Bressler, P., Kopyt, N., Cathcart, H., Bloom, S., Reichel, R., Nakhle, S., Dulude, E., Tarkan, J., Baker, P., Zeig, S., Moya Hechevarria, J., Ropero-Cartier, A., De la Calle, G., Doshi, A., Saba, F., Sligh, T., Shaw, S., Kumar, J., Szerlip, H., Bayliss, G., Perlman, A., Sakhrani, L., Gouge, S., Argoud, G., Acosta, I., Elder, J., Sensenbrenner, J., Vicks, S., Mangoo-Karim, R., Galphin, C., Leon-Forero, C., Gilbert, J., Brown, E., Ijaz, A., Butt, S., Markell, M., Arauz-Pacheco, C., Sloan, L., Alvarado, O., Jabbour, S., Simon, E., Rastogi, A., James, S., Hall, K., Melish, J., Dixon, B., Adolphe, A., Kovesdy, C., Beddhu, S., Solomon, R., Fernando, R., Levin, E., Thakar, C., Robey, B., Goldfarb, D., Fried, L., Maddukuri, G., Thomson, S., Annand, A., Kronfli, S., Kalirao, P., Schmidt, R., Dahl, N., Blumenthal, S., Weinstein, D., Ostergaard, O., Weinstein, T., Ono, Y., Yalcin, M., Karim, S., Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, and Diabetes Clinic

Subjects
Male, endothelin, albuminuria, nephropathy, inhibition, Diabetes Mellitus, Type 2/drug therapy, Endocrinology, Diabetes and Metabolism, Placebo-controlled study, Administration, Oral, 030204 cardiovascular system & hematology, Settore MED/13 - Endocrinologia, chemistry.chemical_compound, 0302 clinical medicine, ENDOTHELIN, 80 and over, Diabetic Nephropathies, 030212 general & internal medicine, Renal Insufficiency, Chronic, Aged, 80 and over, Diabetic Nephropathies/blood, General Medicine, Middle Aged, Atrasentan/administration & dosage, Editorial Commentary, Treatment Outcome, Nephrology, Creatinine, Administration, young adult, Female, medicine.symptom, Glomerular filtration rate, Type 2, Endothelin A Receptor Antagonists/administration & dosage, medicine.drug, Glomerular Filtration Rate, Human, Oral, Adult, medicine.medical_specialty, ALBUMINURIA, Endothelin A Receptor Antagonists, NEPHROPATHY, Urology, INHIBITION, Renal function, Serum Albumin, Human, Placebo, Nephropathy, 03 medical and health sciences, Young Adult, Double-Blind Method, Atresentan, diabetes, chronic kidney disease, medicine, Diabetes Mellitus, Aged, Atrasentan, Diabetes Mellitus, Type 2, Humans, Renal Insufficiency, Chronic, Serum Albumin, business.industry, Creatinine/blood, medicine.disease, Serum Albumin, Human/urine, n/a OA procedure, chemistry, Albuminuria, Renal Insufficiency, Chronic/blood, business, aged, 80 and over, Kidney disease
Abstract

Background Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.Methods We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18-85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR) 25-75 mL/min per 1.73 m(2) of body surface area, and a urine albumin-to-creatinine ratio (UACR) of 300-5000 mg/g who had received maximum labelled or tolerated renin-angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0.75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders) were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0.75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for >= 30 days) or end-stage kidney disease (eGFR = 90 days, chronic dialysis for >= 90 days, kidney transplantation, or death from kidney failure) in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials. gov, number NCT01858532.Findings Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325) or placebo group (n=1323). Median follow-up was 2.2 years (IQR 1.4-2.9). 79 (6.0%) of 1325 patients in the atrasentan group and 105 (7.9%) of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR] 0.65 [95% CI 0.49-0.88]; p=0.0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3.5%) of 1325 patients in the atrasentan group and 34 (2.6%) of 1323 patients in the placebo group (HR 1.33 [95% CI 0.85-2.07]; p=0.208). 58 (4.4%) patients in the atrasentan group and 52 (3.9%) in the placebo group died (HR 1.09 [95% CI 0.75-1.59]; p=0.65).Interpretation Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Copyright (C) 2019 Elsevier Ltd. All rights reserved.

Published
2019

46. Design science and design research: The significance of a subject-specific research approach

Author

Bettina Rösken-Winter, Marcus Nührenbörger, Anna Susanne Steinweg, Michael Link, Susanne Prediger, and PHSG - Institut Lehr-Lernforschung

Subjects
Research design, Structure (mathematical logic), Scope (project management), Management science, Learning environment, Perspective (graphical), Key (cryptography), Design science, Focus (linguistics), Learning environments, Teaching experiments, Learning processes, Key ideas
Abstract

Jahnke, H. N., & Hefendehl-Hebeker, L. (Eds.). (2019). Traditions in German-speaking mathematics education reserach (ICME-13 Monographs). Cham: Spinger Open, , pp. 61-89., Considering mathematics education as a DESIGN SCIENCE has strong roots in Germany. E. Ch. Wittmann in particular contributed to the establishment of this approach. From a DESIGN SCIENCE perspective, substantial learning environments play a crucial role. They comprise mathematical tasks which are connected in an operative way, indicative of a specific epistemological structure. In such substantial learning environments, students are actively immersed in learning mathematics, and the learning environments allow for the pursuit of individual and differentiated learning processes. In this chapter, we first address the scope of Design Science and pay attention to characteristics of the learning environments and how teaching experiments can be conducted. We then focus on key ideas and their role as a design principle. In the next section, we provide a comprehensive example of designing a learning environment. Lastly, we shift our attention to the Design Research approach, which complements designing substantial learning environments by empirically studying the initiated learning processes to gain evidence for both theoretical considerations and design principles.

Published
2019

48. Handbuch Fahrrad und E-Bike : Alle relevanten Lösungen auf dem Markt - Unabhängige Beratung - Empfehlungen aus der Praxis - Zahlreiche Tests: Alles zu Ausstattung, Technik und Zubehör

Author

Michael Link and Michael Link

Abstract

Was gibt es Neues in Sachen Fahrrad, Fahrradzubehör und Zweiradtechnik? Was ist sinnvoll und bringt echte Vorteile?'Fahrrad und E-Bike. Das große Technikhandbuch'ist ein detaillierter Ratgeber zu City-Fahrrad, Trekkingbike, Mountainbike, Rennrad oder E-Bike. Neben den aktuellsten E-Bike- und Fahrrad-Tests der Stiftung Warentest erfahren Einsteiger und Profis mit unterhaltsamen Anekdoten zu historischen Entwicklungsschritten in der Fahrradtechnik alles um die Zweirad-Tradition. Fahrradbegeisterung garantiert! Egal ob Fahrradhelm, Sattel, Lenker, Bremshebel oder Lastenanhänger: Von Bremsscheiben bis Umwerfer werden alle Komponenten in jeder angebotenen Variante eingehend erklärt. Ebenso werden Wartungsaufwand, Reparaturen, Nutzen und neueste Trends für jedes Bauteil gezeigt. Auch E-Bikes und Pedelecs sowie spezielle E-Bike-Themen wie E-Bike-Motoren, Pedelec-Akkus oder Fahrradcomputer finden ihre umfassende Darstellung. Darüber hinaus sind Neuheiten erläutert, darunter Smart-Bikes, integrierte Akkus oder Multifunktionshelme. Dieser Ratgeber enthält wirklich alles zu Ausstattung, Technik und Zubehör.

Published
2020

49. Conflict and cooperation in the water‐security nexus: a global comparative analysis of river basins under climate change

Author

Tobias Ide, Juergen Scheffran, and P. Michael Link

Subjects
Resource (biology), 010504 meteorology & atmospheric sciences, media_common.quotation_subject, 0208 environmental biotechnology, Water supply, Ocean Engineering, 02 engineering and technology, Management, Monitoring, Policy and Law, Aquatic Science, Oceanography, 01 natural sciences, Water scarcity, Scarcity, Environmental planning, 0105 earth and related environmental sciences, Water Science and Technology, media_common, Ecology, business.industry, Global warming, Environmental resource management, 020801 environmental engineering, Water resources, Water security, business, Nexus (standard)
Abstract

Adequate fresh water availability is an important factor for human security in many parts of the world. In transboundary river basins, decreased water supply due to local environmental change and global climate change and increased water demand due to growing populations and continued economic development can aggravate water scarcity. Contrary to the claim that water scarcity may result in an increased risk of armed conflict, there is no simple relationship between freshwater availability and violent conflict. Other crucial factors need to be taken into consideration that also directly influence resource availability and personal human well-being. In this review, we assess the scientific literature on conflict and cooperation in transboundary river systems. Most international river basins are already jointly managed by the riparians, but successful management in times of climate change necessitates the inclusion of more factors besides mere allocation schemes. On the basis of a substantial body of literature on the management of transboundary watersheds, an analytical framework of the water-security nexus is developed that integrates the physical and socioeconomic pathways connecting water availability with conflict or cooperation. This framework is subsequently applied to two transboundary river basins—the Nile River and the Syr Darya/Amu Darya—as they represent two world regions that could become future water hot spots. An improved understanding of the developments leading to water conflicts and their interaction can help to successfully reduce the risk of water conflicts in these regions and to move toward increased cooperation among the riparians of transboundary river systems. WIREs Water 2016, 3:495–515. doi: 10.1002/wat2.1151. This article is categorized under: Engineering Water > Planning Water Science of Water > Water and Environmental Change Human Water > Water Governance.

Published
2016

50. They sow the wind and reap bioenergy

Author

Jürgen Scheffran, P. Michael Link, and Kesheng Shu

Subjects
German, Schleswig holstein, Wind power, business.industry, Bioenergy, language, Economics, Energy transition, business, language.human_language, Agricultural economics
Published
2018

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