Search

In the context of teaching workforce shortages, this study examined teachers' perceptions of safety, role satisfaction, and their intent to remain in the profession, in Australia. Findings from two iterations of a survey of a total of 8293 teachers revealed that 20% to 25% of participants felt unsafe in their schools. The results also showed that those who felt unsafe were less likely to be satisfied with the role and more likely to intend to leave the profession. Sources of safety concerns included student and parent behaviors along with a lack of support from schools and systems. The findings highlight an urgent need to better understand how schools and education systems might foster safer, more inclusive and positive learning environments.

Abstract The rapid increase in the population, urbanization, increasing standard of living, indifference, and other factors can be used to explain the concerning rate of waste generation. Research suggests that most countries prefer to process and dispose of their waste via open dumping or landfilling due to its affordability and simple mechanism. However, leachate and landfill gas emissions present environmental risks associated with landfilling. To prevent landfilling’s detrimental impacts on the ecosystem, alternative methods of disposing of organic waste need to be investigated. An environmental impact analysis was undertaken utilizing the openLCA software to evaluate the ecological footprints of three distinct waste management strategies i.e., Landfilling, Composting, and composting using EP-50 assessing four key environmental indicators. Composting using EP-50 (EcoProbe 50) is a recent advancement towards waste management where organic waste is turned to compost artificially under high temperature and pressure along with constant mixing and churning of the waste for better nutrient value. The EP-50 composter, according to our research hypothesis, offers a greener option to conventional landfilling and composting. We evaluated the potential for global warming, acidification, eutrophication, and human toxicity of landfilling, conventional composting, and EP-50 composting utilizing Life Cycle Assessment (LCA). According to our findings, the EP-50 system minimizes the potential for global warming to around 420 kgCO2 eq in comparison to 1243 kgCO2 eq from conventional composting and 4653 kgCO2 eq for landfilling. In addition, EP-50 increases the amount of nutrients in the compost generated while reducing the effects of eutrophication and acidification by more than 15%. These results demonstrate EP-50 as a scalable and effective method for managing organic waste.

The importance of educational technologies continues to be revealed in contemporary classrooms and has consequently resulted in calls for those in initial teacher education programs to engage with contexts in which they can develop and demonstrate their technological, pedagogical and content knowledge (TPACK). Despite TPACK being one of the world's most frequently used frameworks for understanding teachers’ technology integration (Hew et al., 2019; Niederhauser & Lindström, 2018), conceptualisations of the contexts in which pre-service teachers develop and demonstrate their TPACK are often confined to physical locations (Phillips et al., 2016; Phillips, 2016b; Rosenberg & Koehler, 2015). This research takes a broader consideration of ‘context’ through explorations of empirical data from a study of Australian pre-service teachers (PSTs) collaboratively planning, delivering and reflecting on team-taught, online, high school STEM classes in an attempt to answer the research question driving this research: What contextually situated learning process shape pre-service teachers’ TPACK development? Data from a series of semi-structured interviews revealed changes in the ways in which pre-service teachers conceptualised their TPACK. More importantly, this study found that the situated learning processes of induction, transferability, positive interdependence, synchronicity, and negotiability (Johnson and Johnson, 1994; Dillenbourg, 1999) were particularly important in explaining how participants understood and explained their TPACK acquisition and enactment. This research also highlights the importance of intentional design decisions by teacher educators to consider broader conceptualisations of ‘contexts’ which illustrate the importance of situated and collaborative learning opportunities to shape pre-service teachers TPACK. Importantly, these designs in this setting also empowered pre-service teachers to take risks with their praxis as they reported a feeling of emotional safety when teaching with a liminal peer. Consequently, the power of collaborative processes and interactions were revealed as new contextual considerations in the TPACK framework.

Background Direct endoluminal imaging, such as with our previously described microangioscope, is an emerging adjunct in endovascular cerebral aneurysm management that enables clinicians to delineate between thrombi and visualize neoepithelialization after stent placement with high resolution. The present study sought to study flow diversion in vivo under direct endoluminal imaging, and to validate our findings with histopathology. Methods In a rabbit model, we implanted each left common carotid artery with a shielded flow diverter (FD) (Medtronic Pipeline Vantage) and nonshielded FD (Medtronic Pipeline Flex) in the right common carotid artery. We studied 9 animals in 3 groups: (1) no periprocedural antiplatelet therapy, (2) aspirin 81 mg daily, and (3) aspirin 81 mg and clopidogrel 75 mg daily. FD thrombosis, stenosis, malapposition, and neoepithelialization were all evaluated by diagnostic cerebral angiography and microangioscopy after 30 days. Diagnostic cerebral angiography and angioscopic video were analyzed by independent evaluators and compared with histopathologic analysis. Results In the aspirin and dual antiplatelet therapy groups, there were no significant observed differences in stent thrombosis, stenosis, malapposition, or neoepithelialization between the shielded and non‐shielded FD groups. There was significantly more thrombus formation in Group 1. Neointimal thickness as measured by the microangioscope was highly correlated with histology (r = 0.72; P = 0.016). Interrater agreement of microangioscope videos was highest for FD thrombosis and stenosis. Conclusion In‐stent thrombosis, stenosis, malapposition, and neopithelialization demonstrated no significant difference between shielded and non‐shielded FDs. Microangioscopy measurements for neointimal thickness were highly correlated with pathology and may be a helpful adjunct to diagnostic cerebral angiography in FD follow‐up.

Background: Ventilator associated pneumonia (VAP) is associated with significant rates of morbidity and all-cause mortality. Active VAP surveillance can identify risk factors for which targeted preventive measures can be implemented. However, surveillance efforts are complicated by challenges associated with accurate VAP diagnosis. We aimed to improve the accuracy and automation of existing VAP diagnostic algorithms to better identify patients at risk. Methods: The study was conducted at NYU Langone Health from June 2022 through December 2023. We created a semi-automated VAP surveillance system using the Centers for Disease Control & Prevention (CDC) ventilator associated event (VAE) definition as a base framework (Figure 1). We modified this definition to include additional elements, such as having a sputum culture ordered within 48 hours of worsening oxygen status, regardless of culture result. Using this algorithm—followed by manual clinician reviews—we retrospectively assessed possible VAP cases to determine the ability of our surveillance system to correctly identify VAP. Results: Of the 123 possible VAP cases identified through our automated system, 75 (61%) were correctly diagnosed as VAP after clinical review. This reflects a rate of 1.5 infections per 1000 ventilation days across the system and 1.85 infections per 100 patients ventilated for greater than 2 days. Of the 48 remaining patients without VAP after clinical review, 25% (n=12) were characterized as having hospital-acquired pneumonia, 21% (n=10) as acute respiratory distress syndrome or infection at another site and 10% (n=5) as pulmonary embolism/infarction. Among all patients identified through this automated system (VAP and non-VAP), 53% experienced in-hospital death. Discussion: Our automated VAP surveillance algorithm identified 123 cases of potential VAP, 61% of which were consistent with a clinical diagnosis of VAP upon manual chart review. Our VAP rate of 1.5 infections per 1000 ventilation days was similar to published rates at other North American hospital systems. The high in-hospital mortality rate among these patients highlights the need for improved surveillance systems and earlier interventions to reduce the risk of VAP. There are several limitations to the CDC’s VAE definition, including its requirement of a positive microbiologic culture and focus on sputum quality. This potentially misses cases of culture-negative VAP in patients receiving antibiotics prior to sputum collection. Our goal is to continue to validate and improve our algorithm’s ability to correctly identify patients with clinical VAP, so that targeted prevention efforts can be focused upon the patients with the highest risk for poor outcomes.

Abstract Cell cycle transitions result from global changes in protein phosphorylation states triggered by cyclin-dependent kinases (CDKs). To understand how this complexity produces an ordered and rapid cellular reorganisation, we generated a high-resolution map of changing phosphosites throughout unperturbed early cell cycles in single Xenopus embryos, derived the emergent principles through systems biology analysis, and tested them by biophysical modelling and biochemical experiments. We found that most dynamic phosphosites share two key characteristics: they occur on highly disordered proteins that localise to membraneless organelles, and are CDK targets. Furthermore, CDK-mediated multisite phosphorylation can switch homotypic interactions of such proteins between favourable and inhibitory modes for biomolecular condensate formation. These results provide insight into the molecular mechanisms and kinetics of mitotic cellular reorganisation.

Background Anterior cruciate ligament injury of the knee is common and leads to decreased activity and risk of secondary osteoarthritis of the knee. Management of patients with a non-acute anterior cruciate ligament injury can be non-surgical (rehabilitation) or surgical (reconstruction). However, insufficient evidence exists to guide treatment. Objective(s) To determine in patients with non-acute anterior cruciate ligament injury and symptoms of instability whether a strategy of surgical management (reconstruction) without prior rehabilitation was more clinically and cost-effective than non-surgical management (rehabilitation). Design A pragmatic, multicentre, superiority, randomised controlled trial with two-arm parallel groups and 1:1 allocation. Due to the nature of the interventions, no blinding could be carried out. Setting Twenty-nine NHS orthopaedic units in the United Kingdom. Participants Participants with a symptomatic (instability) non-acute anterior cruciate ligament-injured knee. Interventions Patients in the surgical management arm underwent surgical anterior cruciate ligament reconstruction as soon as possible and without any further rehabilitation. Patients in the rehabilitation arm attended physiotherapy sessions and only were listed for reconstructive surgery on continued instability following rehabilitation. Surgery following initial rehabilitation was an expected outcome for many patients and within protocol. Main outcome measures The primary outcome was the Knee Injury and Osteoarthritis Outcome Score 4 at 18 months post randomisation. Secondary outcomes included return to sport/activity, intervention-related complications, patient satisfaction, expectations of activity, generic health quality of life, knee-specific quality of life and resource usage. Results Three hundred and sixteen participants were recruited between February 2017 and April 2020 with 156 randomised to surgical management and 160 to rehabilitation. Forty-one per cent (n = 65) of those allocated to rehabilitation underwent subsequent reconstruction within 18 months with 38% (n = 61) completing rehabilitation and not undergoing surgery. Seventy-two per cent (n = 113) of those allocated to surgery underwent reconstruction within 18 months. Follow-up at the primary outcome time point was 78% (n = 248; surgical, n = 128; rehabilitation, n = 120). Both groups improved over time. Adjusted mean Knee Injury and Osteoarthritis Outcome Score 4 scores at 18 months had increased to 73.0 in the surgical arm and to 64.6 in the rehabilitation arm. The adjusted mean difference was 7.9 (95% confidence interval 2.5 to 13.2; p = 0.005) in favour of surgical management. The per-protocol analyses supported the intention-to-treat results, with all treatment effects favouring surgical management at a level reaching statistical significance. There was a significant difference in Tegner Activity Score at 18 months. Sixty-eight per cent (n = 65) of surgery patients did not reach their expected activity level compared to 73% (n = 63) in the rehabilitation arm. There were no differences between groups in surgical complications (n = 1 surgery, n = 2 rehab) or clinical events (n = 11 surgery, n = 12 rehab). Of surgery patients, 82.9% were satisfied compared to 68.1% of rehabilitation patients. Health economic analysis found that surgical management led to improved health-related quality of life compared to non-surgical management (0.052 quality-adjusted life-years, p = 0.177), but with higher NHS healthcare costs (£1107, p

The following describes a case of isolated visceral angioedema related to an angiotensin II receptor blocker (ARB) medication. Additionally, we discuss the pathophysiology of drug-induced angioedema, various presentations that can be encountered, and the leading theorized mechanisms of how renin-angiotensin-aldosterone system (RAAS) blocking medications lead to angioedema. The goal of sharing this case is to help increase awareness of the possibility of ARB-induced angioedema and to recommend keeping visceral angioedema as part of the differential diagnosis when presented with a patient who is taking an angiotensin converting enzyme inhibitor (ACEI) or ARB medication that is experiencing gastrointestinal symptoms of unclear etiology.

Bioactive peptides are the compounds used as medicines, nutraceuticals and food preservatives. In this study, lupin protein hydrolysates were produced by enzymatic hydrolysis using pepsin, pancreatin and flavourzyme and antioxidative activities of the hydrolysates were measured. Protein was isoelectrically isolated from the lupin seed flour and enzymatically hydrolysed. The hydrolysates were ultrafiltered using molecular weight cut-off (MWCO) membranes. Fractions with masses of

Abstract Identifying relevant studies and harmonizing datasets are major hurdles for data reuse. Common Data Elements (CDEs) can help identify comparable study datasets and reduce the burden of retrospective data harmonization, but they have not been required, historically. The collaborative team at PhenX and dbGaP developed an approach to use PhenX variables as a set of CDEs to link phenotypic data and identify comparable studies in dbGaP. Variables were identified as either comparable or related, based on the data collection mode used to harmonize data across mapped datasets. We further added a CDE data field in the dbGaP data submission packet to indicate use of PhenX and annotate linkages in the future. Some 13,653 dbGaP variables from 521 studies were linked through PhenX variable mapping. These variable linkages have been made accessible for browsing and searching in the repository through dbGaP CDE-faceted search filter and the PhenX variable search tool. New features in dbGaP and PhenX enable investigators to identify variable linkages among dbGaP studies and reveal opportunities for cross-study analysis.

The Rover–Aerial Vehicle Exploration Network project field-tested planetary mission operations within a Mars analog environment in Iceland using stand-alone rover and helicopter architectures. Mission planning, implementation, and results are reported for the rover mission and briefly summarized for the helicopter mission. The outcomes of both missions are subsequently compared. Field implementation occurred from 2022 July to August at the Holuhraun lava flow. The rover science operations team executed a 14 sol (Martian day) mission that achieved mission, science, and sampling goals, including the contextualization, acquisition, and planned caching of two eolian and two rock samples. The helicopter science operations team executed a plan of comparable length but emphasized different science goals given long-range flight capabilities and landing limitations. The resolution and targetability of the rover payload enabled more detailed analyses, whereas the helicopter was better able to map flow-scale morphologies. The rover’s exploration was limited by daily mobility duration limits and hazardous terrain, whereas the helicopter’s exploration was constrained by landing site hazards. Resource limitations resulted from lengthier rover drives and data-volume-intensive helicopter imaging surveys. Future missions using combined rover–helicopter architectures should account for each spacecraft’s resource needs and acknowledge system strengths in different geologic settings. Both missions served to establish operations strategies and mission outcomes to be applied to future combined rover and helicopter mission architectures, while the helicopter mission also evaluated strategies and outcomes for future stand-alone airborne missions. Findings in this work are relevant to future missions seeking to optimize strategies for planetary mission operations.

Planetary analog mission simulations are essential for testing science operations strategies and technologies. They also teach us how to use terrestrial analogs to inform studies of extraterrestrial environments. Unoccupied aircraft systems (UASs) have great potential for planetary surface exploration as demonstrated by the Mars 2020 Ingenuity helicopter and the in-development Dragonfly mission to Saturn’s moon Titan. Although applications of UAS technology for planetary exploration remain largely unexplored, simulated missions in planetary analog terrains can inform operational best practices. As part of the Rover–Aerial Vehicle Exploration Network project, we simulated a 12 sol UAS mission on Mars in the Holuhraun region of Iceland. The UAS had airborne imaging capability, as well as imaging, sampling, and geochemical analysis capabilities while landed. The mission evaluated the use of these instruments and developed operational strategies for using UASs to explore a planetary surface. Oblique airborne images were essential for mission planning and were used to scout large areas to identify both potential landing sites and targets for focused investigations. The airborne and landed data collected by the UAS allowed for detailed observations and interpretations not possible with analog orbital data sets, resulting in an improved scientific return for the simulated UAS mission compared to a premission analysis of only the analog orbital data. As a planetary exploration vehicle, a UAS is most advantageous for exploring large areas (many square kilometers) and is particularly useful when the terrain may be impassable to ground-based traverses (e.g., by rovers or humans).

Background The management of modifiable risk factors and comorbidities may impact the future trajectory of cognitive impairment, but easy-to-implement management methods are lacking.Aims This study investigated the effects of simple but comprehensive cognitive health management practices on the cognitive function of older adults in the community with normal cognition (NC) and mild cognitive impairment (MCI).Methods The comprehensive cognitive health management programme included a psychiatric assessment of the cognitive risk factors for those in the intervention groups and individualised recommendations for reducing the risks through self-management supported by regular medical professional follow-up. The intervention groups for this study included 84 elderly participants with NC and 43 elderly participants with MCI who received comprehensive cognitive health management. The control groups included 84 elderly participants with NC and 43 elderly participants with MCI who matched the intervention group’s general characteristics and scale scores using the propensity matching score analysis. The Montreal Cognitive Assessment (MoCA) scale and Geriatric Depression Scale (GDS) scores were compared after a 1-year follow-up.Results For older adults with MCI in the intervention group, MoCA scores were higher at the 1-year follow-up than at baseline (24.07 (3.674) vs 22.21 (3.052), p=0.002). For the MoCA subscales, the intervention group’s abstract and delayed memory scores had significantly increased during the 1-year follow-up. Furthermore, in a generalised linear mixed model analysis, the interaction effect of group×follow-up was statistically significant for the MCI group (F=6.61, p=0.011; coefficients=5.83).Conclusions After the comprehensive cognitive health management intervention, the older adults with MCI in the community showed improvement at the 1-year follow-up. This preliminary study was the first to demonstrate an easy-to-implement strategy for modifying the cognitive risk factors of elderly individuals with MCI in the community, providing new insight into early-stage intervention for dementia.

Background: Outpatient parenteral antimicrobial therapy (OPAT) is used in the outpatient setting to treat infectious conditions that require a prolonged course of antimicrobials. OPAT has been shown to decrease length of hospital stay and healthcare costs without compromising patient care and has become a widely accepted practice nationally. Due to this trend, the study of OPAT is of vital importance and will continue to be relevant moving forward. Currently, few studies have explored risk factors associated with OPAT complications, and most are limited in their analysis by indication. Further work should be performed to expand upon what is currently known. We characterized factors associated with increased OPAT complication risk. Methods: We conducted a retrospective cohort study at 4 sites across NYU Langone Health in patients admitted from 2017 to 2020. We applied the following inclusion criteria: aged ≥18 years and discharged with OPAT. Complications were defined as follows: vascular-access-related (line occlusion, thrombosis, dislodgement, central-line associated bloodstream infection or CLABSI) and antimicrobial-related (laboratory derangement, drug reaction, Clostridioides difficile infection), all-cause 30-day readmission, and OPAT-related readmission. Data were obtained from electronic medical records and the OPAT database. This study was granted a waiver from informed consent by the NYU Institutional Review Board. Multivariate logistic regression was performed, adjusting for confounding variables (sex, age, hospital of admission, history of chronic medical conditions, line type, and line duration). Results: Overall, 1,846 patient encounters of 5,951 reviewed met inclusion criteria. The median age was 66 (IQR, 26), 42.2% were female. Moreover, 810 (44%) received a peripherally inserted central catheter (PICC) and 1,036 (56%) received a midline cathether. Also, 563 (30.5%) were discharged to subacute rehabilitation (SAR). The most frequent complications were line dislodgement (4.2% of all patients), laboratory derangement (3.0%), and drug reaction (2.4%). Furthermore, 27 patients (1.5%) developed CLABSI. Patients discharged to SAR were more likely to develop CLABSI (OR, 4.1l; P = .005), and they had higher rates of OPAT-related 30-day readmissions (OR, 2.675; P = .004) compared to those who were discharged home, after adjusting for key confounders. Conclusions: Discharge to SAR is strongly associated with increased risk of readmission for OPAT-related complications and CLABSI, after adjusting for key confounders. CLABSI prevention during SAR admission is a critically needed public health intervention.

In 2019, there were multiple outbreaks of measles in the United States. In the context of the public awareness of these outbreaks, we performed an intervention with the intent to improve the rate of measles immunization in our pediatric population. Pediatric patients that were lacking adequate measles immunization were identified by electronic medical record (EMR) survey. Charts were reviewed and updated if records were found to be incomplete. Parents of the remaining children were sent a letter, personally signed by the child’s primary care provider, encouraging measles immunization. A measles fact sheet, produced by the United States Center for Disease Control, was also included with the letter. There were 44 patients in the study group whose parents received a letter and measles fact sheet. As a result, 5 of these children were brought in for a measles, mumps, and rubella (MMR) immunization. The 44 patients whose parents received a letter included 20 patients whose parents had previously expressed intent to not vaccinate their children as documented in the EMR. None of these children received an MMR immunization. Although small in scope, this project provides a glimpse into the importance of personal provider guidance to parents who are inclined to immunize their children. Unfortunately, it also demonstrated that provider advice did not change the opinions of parents who had already taken a stance against vaccination, even in the context of an urgent public health situation that had garnered widespread coverage in the lay press and social media.

An iodine-mediated hydration reaction of alkynes serves as a green alternative to metal-catalyzed procedures. Previous work has shown that this method works well with terminal alkynes on keto-functionalized scaffolds, including 1,3-dicarbonyls and their heteroatom analogues. It was hypothesized that the reaction proceeds through a 5-exo-dig neighboring group participation (NGP) cyclization and an α-iodo intermediate. The work described herein probes the existence of the intermediate through NMR investigations and explores the scope of the hydration process with internal alkynes. The NMR experiments confirm the existence of the α-iodo intermediate, and methodology studies demonstrate that alkyl-capped, asymmetric, internal alkynes undergo a regiospecific hydration, also via the 5-exo-dig NGP pathway.

Climate information services (CIS) are increasingly in demand to assist farmers in managing risks associated with climate variability and extremes experienced in food production. However, there are significant gaps in the availability and accessibility of these services, especially in aquatic food production in developing countries. In response, this study aims to generate the background knowledge for developing climate information and decision support services tailored for aquaculture farmers in Bangladesh. We surveyed 800 fish-farming households, interviewed 30 key informants, and conducted a systematic literature review to identify climate-sensitive operations and management decisions in aquaculture and to document fish-farmers' awareness of the relationships between climate variability and aquatic food production systems. We also sought to identify the lead time and communication method(s) needed to deploy forecasts effectively and prepare aquaculture farmers to act in response to the forecasts. A fish-farming activity calendar was developed that identified high temperature, cold spell, heavy rainfall, and dry spell events as key climatic phenomena affecting year-round aquaculture operations, including pond preparation and maintenance, fingerling stocking, grow-out management, and harvesting. We also identified five climate-sensitive management decision points and 26 potential advisories in line with specific climate variability to manage induced risks in the day-to-day operations of fish farmers. Finally, the research team developed a decision framework based on the temperature and rainfall thresholds for the grow-out phase of four widely cultivated and economically important fish species in Bangladesh. This innovative decision support approach is to our knowledge the very first endeavor to develop CIS using species-specific temperature and rainfall thresholds to reduce climate risks and ensure resilience capacity for South Asian aquaculture system.

Methods We developed a prediction model to predict patients at risk for mortality using only laboratory, vital and demographic information readily available in the electronic health record on more than 3395 hospital admissions with COVID-19. Multiple methods were applied, and final model was selected based on performance. A variable importance algorithm was used for interpretability, and understanding of performance and predictors was applied to the best model. We built a model with an area under the receiver operating characteristic curve of 83–97 to identify predictors and patients with high risk of mortality due to COVID-19. Oximetry, respirations, blood urea nitrogen, lymphocyte per cent, calcium, troponin and neutrophil percentage were important features, and key ranges were identified that contributed to a 50% increase in patients’ mortality prediction score. With an increasing negative predictive value starting 0.90 after the second day of admission suggests we might be able to more confidently identify likely survivorsDiscussion This study serves as a use case of a machine learning methods with visualisations to aide clinicians with a better understanding of the model and predictors of mortality.Conclusion As we continue to understand COVID-19, computer assisted algorithms might be able to improve the care of patients.

Abstract Lupin is an undervalued legume despite its high protein content with known health benefits. In this research, Australian blue lupin protein was isolated and hydrolysed enzymatically to produce bioactive peptides with a view to assess their potential for nutraceutical and therapeutic applications. Pepsin, pancreatin and flavourzyme were used to enzymatically hydrolyse blue lupin protein, and the hydrolysates were subjected to molecular weight cut‐off (MWCO) fractionation. Measurement of biological activities led to the identification of angiotensin converting enzyme (ACE) inhibitory fractions in the molecular weight range of 2–3 and 3–5 kDa. For the most active fractions in this range, the ACE inhibitory activities were very significant with IC50 values from 450 to 600 μg/ml. Blue lupin protein‐derived MWCO fractions were significantly active against Gram‐positive bacteria and only a little inhibition was observed against Gram‐negative bacteria. Pancreatin hydrolysed fractions showed the best antimicrobial activities with several fractions exhibiting ≥85% inhibition against Bacillus cereus and Staphylococcus aureus. These properties reveal the potential of lupin protein hydrolysates for developing antihypertensive and host defence agents. In order to demonstrate the potential of isolated blue lupin protein in food industry, functional properties including water and oil absorption capacity, gelling properties, solubility and emulsifying properties were evaluated and found to be extremely suitable for developing functional foods with enhanced health benefits.

Suicide is the second leading cause of death among young people in India. Over 40% of all suicides occur in people between 15 and 29 years of age. Suicide attempts are estimated to be 15 times more common than suicides and substantially increase the risk of subsequent death. However, there has been little systematic study of the determinants for suicide attempts in young people, which makes it difficult to design contextually appropriate and comprehensive suicide prevention strategies for this population. The proposed case-control study seeks to address this knowledge gap by studying a range of risk and protective factors for suicide attempts in young people in India. Field work will be in Yashwantrao Chavan Memorial Hospital (YCMH) hospital, in Pimpri-Chinchwad, Pune, India. Cases will be 15-29-year-old individuals admitted to the hospital with self-inflicted non-lethal injuries and poisoning. They will be matched for age and gender with those presenting at the General Medicine outpatient department with other health complaints. In each group, 150 persons will be recruited from YCMH from October 2019 to September 2022 and will undergo a comprehensive semi-structured interview. The primary exposure variable is negative life events over the past 12 months. Secondary exposure variables considered include: demographic characteristics, psychological factors, addictive behaviours, personal resources, adverse experiences over their lifetime, social support, suicidal behaviours in the family and social environment, and exposure to suicide-related information. Data will be analysed using conditional logistic regression. Following completion of the study, workshops will be held with young people, mental health professionals and policy makers to develop a theory of change that will be used to promote suicide prevention. Results will be disseminated via peer-reviewed publications, reports to young people and mental health organisations, and news articles. The study was approved by the Institutional Review Board at Sangath.

Background: The pathogenesis of dementia often starts several years prior to clinical onset during which the individual is asymptomatic. Existing strategies for the accurate diagnosis of early dementia are limited by high cost and the invasive nature of the procedures. Eye movement parameters associated with cognitive functions may be helpful in the early identification of dementia and in the development and evaluation of preventive and therapeutic strategies.Objective: We aimed to assess differences in eye movement parameters between healthy elderly individuals and patients with mild cognitive impairment (MCI). Furthermore, we examined the correlations between eye movement parameters with cognitive functions and specific hemispheric region and neural structures in individuals with MCI.Method: Eighty individuals with MCI without dementia (based on DSM-IV criteria) identified by community screening and 170 healthy controls were administered Chinese versions of MoCA and NTB, and a long (20 min) or short (5 min) version of a visual paired comparison (VPC) task. Two weeks later, 44 MCI patients and 107 healthy controls completed a retest of the VPC task, 44 MCI patients and 43 healthy controls among them administered a MRI. At the end of 1-year follow-up, a subset of 26 individuals with MCI and 57 healthy controls were administered the long version of VPC task and MoCA test again. Eye movement parameters and the relationship of eye movement parameters with cognitive functions and with changes in neural structures were compared between groups.Results: Patients with MCI were older, had less education, and had lower scores on cognitive tests than healthy controls. After adjustment for age and level of education, patients with MCI had lower novelty preference scores on the VPC than healthy controls. Using the logistic regression model, the amount of time that subjects focused on these novel images could predict MCI patients from normal elderly with an out of sample area under the receiver operator characteristic curve of 0.62. Furthermore, the cognition score of subjects whose novelty preference score was low decreased more remarkably in 1 year. For both the patient and control groups, VPC novelty preference was significantly correlated with verbal fluency and delayed and short-term memory function. Novelty preference score was also significantly correlated with the cortical thickness of several structures in the right hemisphere.Conclusion: Eye movement parameters are stable indicators to distinguish patients with MCI and cognitively normal subjects and are not affected by different testing versions and numbers. Additionally, the patients’ cognitive deficits and eye movement indices were correlated. Future longitudinal studies should further explore the clinical utility of eye movement parameters as early markers of MCI.

The present study tests the forecasting strength of widely used asset pricing models, using monthly stock returns of two style-based, large-cap US growth and value index funds for 1993 – 2015. Global variables are added to the models to test the global linkage impact. As we impose a positive forecast returns constraint, there is a considerable reduction in the root mean squared error (RMSE), providing significant economic implications. RMSE of constrained models for non-negativity restriction outperforms the unconstrained models improving them by an average of 17%. As evidenced by the forecasting power measured by RMSE, we found the value stocks to be more predictable with lower overall RMSE when compared to growth stocks. The global models provide better forecast for growth stocks, whereas there are mixed implications for value stocks. The Global Carhart consistently ranks as one of the best models for both growth and value stocks. Keywords: Forecasting Stock Returns, International Asset Pricing, Global Linkage, Growth Versus Value, Predictive Regressions, Root Mean Squared Error JEL Classifiations: G170, G150, G110 DOI: https://doi.org/10.32479/ijefi.9993

Lupin is a major rotational crop produced abundantly in Australia. Three varieties of sweet lupins are grown in Australia depending on soil types and climatic conditions; these are white lupin (Lupinus albus), blue lupin (Lupinus angustifolius), and yellow lupin (Lupinus luteus). In this study, polysaccharides from the three lupin species have been extracted with hot water and a range of their biological activities investigated. The antioxidant activities of lupin polysaccharides have been measured in terms of ABTS•+ radical and hydroxyl radical scavenging activities, and their affinity to chelate with iron. Immune-enhancing power of the lupin polysaccharides was examined by measuring their capacity to stimulate the macrophages (RAW 264.7) to release TNF-α and nitric oxide. The prebiotic activities were determined against the beneficial probiotics such as Lactobacillus rhamnosus DR20, Lactobacillus acidophilus LAFTI L10, Bifidobacterium lactis DR10, and Bifidobacterium animalis BB-12. Polysaccharides from the three lupin species have exhibited significant antioxidant, immunostimulatory, and prebiotic activities. The results demonstrated that blue lupins displayed the best activities, and therefore are expected to possess high potential to be used as nutraceutical and functional ingredients with significant therapeutic value. FT-IR spectroscopic technique was employed for a preliminary structural characterization. Studies involving surface morphology and thermal behavior have indicated that the lupin polysaccharides are suitable for end product development.

In 1788 William Blake invented a technically revolutionary method of printing both word and image together that he called ‘Illuminated Printing.’ Blake’s invention made it possible to print both the text of his poems and the images that he created to illustrate them from the same copper plate, etched in relief (in contrast to conventional etching or engraving in intaglio), unassisted, using his own rolling-press. Significantly, this meant that he became solely responsible not only for the creation, but also for the reproduction of his works, largely free from commercial constraint and entirely free from censorship. The paper explains and illustrates Blake's invention in the context of conventional eighteenth-century illustrated book production, which required two fundamentally different kinds of printing press, a screw- or letter-press as well as a rolling-press, and numbers of highly skilled specialist pressmen. The metaphorical significance of Blake’s method of ‘Illuminated Printing’ is also explored.

The precise delineation of coastal areas subject to past, present, and future erosive processes plays a fundamental role in coastal risk management. Within this framework, satellite data represent a valuable synoptic and multi-temporal information source. Therefore, this research integrated remote sensing and GIS techniques for mapping and modeling shoreline evolution through time. Long-term shoreline’s proxy rates of advance and retreat were determined using Landsat data from the mid-1980s to 2011 and subsequently, a short-term scenario (3 years) was predicted and validated. Two different coastal environments, Oceanic and Mediterranean, were investigated. In the first, different proxies were analyzed, thereby enabling a multi-proxy analysis. Findings showed that the method provided more accurate results in higher energy environments (Oceanic) and where the coastline is not urbanized. Results also highlighted the importance of performing multi-proxy analyses in given study areas, to more reliably define shoreline modeling. Importantly, during the analyses, particular attention was given to assessing uncertainty, which is crucial when outcomes of scientific research are considered for management.

Abstract Background Major burns are life threatening. Fluid resuscitation is required for survival to maintain intravascular volumes and prevent hypovolemic shock. Bioimpedance spectroscopy (BIS) has been recognised as a potential method of monitoring fluid shifts after burn and in other disease states. The aims of this study were to examine the reliability of BIS across different dressing conditions and electrode positions, establish the influence of Acticoat™ on BIS variable measures and determine the validity of whole-body BIS to assess net fluid shift in the presence of moderate to major burns. Methods An observational longitudinal cohort study was conducted from December 2014 to February 2016. Patients with over 15% total body surface area (TBSA) burns and injury less than 48 h were enrolled in the study. BIS triplicate measures were collected in an open wound and with an ActicoatTM dressing (at 5 half hour intervals). Standard and alternate electrode placements were utilised for the reliability analysis and standard placement only for determining the validity of BIS in moderate to major burns. The ImpediMde SFB7 was used to collect whole-body and segmental BIS measures. Stata statistical software, release 14 was utilised to analyse all results. Descriptive analyses were performed and were reported using the means and standard deviations (SD). Results BIS-repeated measures established BIS raw resistance (R), and predicted volume variables were reliable in any condition (intra-class correlation coefficient (ICC) 0.996–0.999, 95% confidence intervals (CI) 0.996–0.999) without a systematic difference. Acticoat™ dressings significantly influenced all BIS-predicted volumes (p ≤ 0.01) as determined by multilevel mixed effects (MLME) linear regression analysis. Validity of BIS was demonstrated by resistance variables significantly decreasing with increasing net ionic fluid shift and increased TBSA (severity of injury) and calculated fluid volumes increasing with increasing net fluid shift and TBSA. BIS resistance also decreased with time as oedema reduced. For clinical use, a calculator was developed to adjust BIS variables when an Acticoat™ dressing is in situ, thus facilitating BIS variable change estimates in real time, with dressings intact. Conclusion BIS may be used clinically to monitor fluid volume change in major acute burns.