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567 results on '"Michael, Oliver"'

2. African cichlid fishes: morphological data and taxonomic insights from a genus-level survey of supraneurals, pterygiophores, and vertebral counts (Ovalentaria, Blenniiformes, Cichlidae, Pseudocrenilabrinae)

Author

Michael Oliver

Subjects
osteology, skeleton, meristic characters, pattern, Biology (General), QH301-705.5
Abstract

The iconic freshwater cichlid fishes (Cichlidae) comprise about 1750 validly named species and hundreds more that are known, but not yet described and named. Cichlids are an important source of protein for millions of people on several continents, are model organisms in studies of evolution, speciation, ecology, development, behaviour and physiology and are popular as aquarium fishes. Yet, comparative studies of cichlid internal anatomy are rare. Even their osteology has not been taxonomically surveyed. The cichlid postcranial skeleton has been especially neglected.Here, I provide the first survey in cichlids of the considerable variation in numbers of vertebrae, supraneurals and dorsal- and anal-fin supports (pterygiophores), as well as the patterns with which the pterygiophores insert between the neural or haemal spines. The study includes some 1700 specimens of nearly 400 cichlid species. Focusing on the largest subfamily, the African cichlids or Pseudocrenilabrinae, the survey furnishes data from species in all but one of its 166 genera. Limited data from species in the other cichlid subfamilies (Etroplinae, Ptychochrominae and Cichlinae) and from the related leaffishes, Polycentridae, are also presented. Key examples of pterygiophore insertion patterns from throughout the range of variation are illustrated and discussed. Detailed analytical tables and all raw data are provided in supplementary files.A bizarre specialisation in Cyprichromis is noted, evidently for the first time. Uniquely in this Lake Tanganyikan genus, five to seven anal pterygiophores are abdominal in position, located anterior to the anal fin and inserting toward or between successive pairs of pleural ribs.Taxonomic changes: The most speciose tribe of African cichlids, currently known as Haplochromini, is correctly called Pseudocrenilabrini. Based chiefly on the molecular phylogenetic findings of other workers, I propose four pseudocrenilabrine subtribes, one occurring in rivers and three endemic to Lake Malawi. I also re-assign the Lake Tanganyikan tribe Tropheini as another subtribe of Pseudocrenilabrini, in line with numerous molecular studies placing tropheines firmly within this tribe. The remaining genera of Pseudocrenilabrini remain incertae sedis in this tribe pending clarification of their phylogenetic relationships.The character complex here surveyed is a promising source of taxonomically and phylogenetically informative characteristics distinguishing or uniting cichlid taxa at multiple hierarchical levels, from species through subfamily. This reference set of novel character data can also provide information for palaeontological studies of African cichlids. These attributes are skeletal features potentially available for study in well preserved fossils and may help determine their correct taxonomic placement.

Published
2024
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3. A novel through-the-scope helix tack-and-suture device for mucosal defect closure following colorectal endoscopic submucosal dissection: a multicenter study

Author

Farha, Jad, Ramberan, Hemchand, Aihara, Hiroyuki, Zhang, Linda Y, Mehta, Amit, Hage, Camille, Schlachterman, Alexander, Kumar, Anand, Shinn, Brianna, Canakis, Andrew, Kim, Raymond E, DʼSouza, Lionel S, Buscaglia, Jonathan M, Storm, Andrew C, Samarasena, Jason, Chang, Kenneth, Friedland, Shai, Draganov, Peter V, Qumseya, Bashar J, Jawaid, Salmaan, Othman, Mohamed O, Hasan, Muhammad K, Yang, Dennis, Khashab, Mouen A, Ngamruengphong, Saowanee, Berrien-Lopez, Rickisha, Mony, Shruti, Mohammed, Zahraa, Bucobo, Juan Carlos, Mahmoud, Tala, Mercado, Michael Oliver M, and Radetic, Mark

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Digestive Diseases, Colo-Rectal Cancer, Humans, Endoscopic Mucosal Resection, Cohort Studies, Intestinal Mucosa, Colorectal Neoplasms, Sutures, Retrospective Studies, ESD-Closure working group, Gastroenterology & Hepatology, Clinical sciences
Abstract

BackgroundComplete closure of large mucosal defects following colorectal endoscopic submucosal dissection (ESD) with through-the-scope (TTS) clips is oftentimes not possible. We aimed to report our early experience of using a novel TTS suturing system for the closure of large mucosal defects after colorectal ESD.MethodsWe performed a retrospective multicenter cohort study of consecutive patients who underwent attempted prophylactic defect closure using the TTS suturing system after colorectal ESD. The primary outcome was technical success in achieving complete defect closure, defined as a

Published
2023

7. The role of protostellar heating in star formation

Author

Jones, Michael Oliver and Bate, Matthew

Subjects
523.8, Physics, Astrophysics, Astronomy, Stars, Molecular Clouds, Star Formation, Initial Mass Function, Protostars, Accretion, Hydrodynamics, Radiative Transfer
Abstract

Previous studies have shown that thermal feedback from protostars plays a key role in the process of low-mass star formation. In this thesis, we explore the effects of protostellar heating on the formation of stellar clusters. We describe new methods for modelling protostellar accretion luminosities and protostellar evolution in calculations of star formation. We then present results of a series of numerical simulations of stellar cluster formation which include these effects, and examine their impact. We begin by investigating the dependence of stellar properties on the initial density of molecular clouds. We find that the dependence of the median stellar mass on the initial density of the cloud is weaker than the dependence of the thermal Jeans mass when radiative effects are included. We suggest that including protostellar accretion luminosities and protostellar evolution may weaken this dependence further, and may account for the observed invariance of the median stellar mass in Galactic star-forming regions. Next, we investigate the effects of including accretion feedback from sink particles on the formation of small stellar groups. We find that including accretion feedback in calculations suppresses fragmentation even further than calculations that only include radiative transfer within the gas. Including feedback also produces a higher median stellar mass, which is insensitive to the sink particle accretion radius used. Finally, we compare calculations of small stellar clusters which model the evolution of protostars using a live stellar model with those which use a fixed stellar structure. We find that the dynamics of the clusters are primarily determined by the accretion luminosities of protostars, but that the relative effects of protostellar evolution depend on the accretion rate and advection of energy into the protostar. We also demonstrate how such calculations may be used to study the properties of young stellar populations.

Published
2018

8. Electrochemical characterization of surfaces of galvanized steels under different exposure conditions using gel electrolytes.

Author

Heyn, Andreas, Meist, Moritz, Michael, Oliver, Babutzka, Martin, Valet, Svenja, and Ebell, Gino

Subjects
GALVANIZED steel, SURFACE analysis, ELECTROLYTIC corrosion, ZINC, ELECTROLYTES, GALVANIZING
Abstract

The corrosion behavior of galvanized steels and zinc components under atmospheric exposure depends mostly on the corrosion product‐based cover layer formation under the prevailing conditions. The use of agar‐based gel electrolytes makes it possible to use electrochemical methods to obtain a characteristic value from these cover layers that describe their current and future protective capacity. It is shown here that different states of galvanized steel can be distinguished very well under laboratory conditions and that this method is also suitable for use under practical conditions. Based on the characteristic values and assuming future time of wetness, it is very easy to draw up a forecast for the future corrosion rate, which provides plausible values. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Addressing health disparities in hispanic communities through an innovative team-based medical spanish program at the medical school level – a single-institution study

Author

Michael Oliver, Taylor Fernberg, Paul Lyons, Sambandam Elango, Gordon J. Green, and Zohray M. Talib

Subjects
Medical Spanish, Medical Spanish program, Hispanic health, Disparities, Spanish OSCE, Spanish interpreters, Special aspects of education, LC8-6691, Medicine
Abstract

Abstract Background There are insufficient Spanish-speaking physicians to effectively serve a large and rapidly growing Spanish-speaking patient population. Methods A team-based hybrid medical Spanish program was designed and implemented at a single medical school in Southern California. This pilot program consisted of a weekly in-person portion where students reviewed Spanish vocabulary and grammar and practiced clinical encounters in teams through active role play. Students supplemented in-class learning with online coursework. Program success was measured through physician-evaluated clinical encounters with Spanish-speaking standardized patients, a 100-question multiple-choice exam, and pre- and post-program surveys. Results 97% of students in the program (n = 32) received a passing grade at program completion. Student surveys demonstrated enthusiasm and engagement in weekly sessions (95% overall attendance, 97% reported feeling either excited or ready to learn prior to class). In a post-program survey, 100% of students felt better suited and increased desire to treat Hispanic patients. Additionally, all students indicated an interest in the continued use of Spanish in both their schooling and future practice. In a follow-up survey after three months of clinical experience in their 3rd year of medical school, 100% of students reported that medical Spanish is "very beneficial" in patient care and that students with medical Spanish proficiency have advantages over non-speaking students when it comes to patient care opportunities. 100% felt that time spent learning medical Spanish during pre-clinical years was time well spent and that the medical Spanish program enhanced their care of Spanish-speaking students. Conclusions The results of the pilot program show a significant increase in the ability of students to engage in clinical interaction in Spanish. The results of our study demonstrate a significant increase in the knowledge, clinical skills, and self-reported confidence of students to treat Hispanic patients. Furthermore, all students not only felt better equipped and more confident to treat Hispanic patients, but they also had an increased desire to do so moving forward in their careers. We conclude that an effective medical Spanish program can be executed simultaneously with a pre-clinical medical school curriculum.

Published
2022
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14. Validating the accuracy of a novel virtual reality platform for determining implant orientation in simulated primary total hip replacement

Author

Daniel Howgate, Michael Oliver, Julie Stebbins, Patrick Garfjeld Roberts, Ben Kendrick, Jonathan Rees, and Stephen Taylor

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Introduction Accurate acetabular cup and femoral stem component orientation are critical for optimising patient outcomes, reducing complications and increasing component longevity following total hip replacement (THR). This study aimed to determine the accuracy of a novel virtual reality (VR) platform in assessing component orientation in a simulated THR model. Methods The VR platform (HTC Vive Pro® system hardware) was compared against the validated Vicon® optical motion capture (MoCap) system. An acetabular cup and femoral stem were manually implanted across a range of orientations into pelvic and femur sawbones, respectively. Simultaneous readings of the acetabular cup operative anteversion (OA) and inclination (OI) and femoral stem alignment (FSA) and neck anteversion (FNA) were obtained from the VR and MoCap systems. Statistical analysis was performed using Pearson product-moment correlation coefficient (PPMCC) (Pearson’s r) and linear regression (R 2 ). Results A total of 55 readings were obtained for the acetabular cup and 68 for the femoral stem model. The mean average differences in OA, OI, FSA and FNA between the systems were 3.44°, −0.01°, 0.01° and −0.04°, respectively. Strong positive correlations were demonstrated between both systems in OA, OI, FSA and FNA, with Pearson’s r = 0.92, 0.94, 0.99 and 0.99, and adjusted R 2 = 0.82, 0.9, 0.98 and 0.98, respectively. Conclusion The novel VR platform is highly accurate and reliable in determining both acetabular cup and femoral stem component orientations in simulated THR models. This adaptable and cost-effective digital tracking platform may be modified for use in a range of simulated surgical training and educational purposes, particularly in orthopaedic surgery.

Published
2022
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15. Migration--A New Normal: A Christian Perspective

Author

Bothner, Michael Oliver

Subjects
Refugees -- Religious aspects, Emigration and immigration -- Religious aspects, Religions -- Relations, Philosophy and religion, Regional focus/area studies
Abstract

In 2016, in the midst of the so-called 'refugee crisis', the author was asked to give the keynote speech from the Christian perspective at the 44th International Conference for inter-religious dialogue amongst Jews, Christians and Muslims (JCM). This article is the edited version of this lecture. Due to the conference's framework, the article is predominantly based on personal experiences and expertise of the author. It outlines causes for people who seek refuge, raises questions about how this whole issue is being dealt with, and mainly engages with the topic of representation and perception of the situation and its challenges and consequences. At a time in which people leaving their home, be it voluntary or forced, is at an all-time high and seems to be becoming a common act, the author concludes that we need to reinterpret our understanding of these movements in order to share a peaceful and just life in community. Keywords: Adichie, asylum, community, discrimination, globalisation, racism, refuge(e), single story, For about eight months now, I have been the uncle of Rubi and Hanna. They are the children of my older brother Stefan and his wife Silvia. It seems to [...]

Published
2020
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17. Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex

Author

Tae Won Yi, Brendan Smyth, Gian Luca Di Tanna, Clare Arnott, Kathryn Cardoza, Amy Kang, Carol Pollock, Rajiv Agarwal, George Bakris, David M. Charytan, Dick de Zeeuw, Hiddo J.L. Heerspink, Bruce Neal, David C. Wheeler, Christopher P. Cannon, Hong Zhang, Bernard Zinman, Vlado Perkovic, Adeera Levin, Kenneth W. Mahaffey, Meg Jardine, Barry M. Brenner, Tom Greene, Meg J. Jardine, Gary Meininger, Nicole Li, Inna Kolesnyk, Diego Aizenberg, Roberto Pecoits-Filho, David Cherney, Gregorio Obrador, Glenn Chertow, Tara Chang, Carmel Hawley, Linong Ji, Takashi Wada, Vivekanand Jha, Soo Kun Lim, Mary Anne Lim-Abrahan, Florence Santos, Dong-Wan Chae, Shang-Jyh Hwang, Evgueniy Vazelov, Ivan Rychlík, Samy Hadjadj, Vera Krane, László Rosivall, Luca De Nicola, Alexander Dreval, Michał Nowicki, Adalbert Schiller, Larry Distiller, Jose L. Górriz, Mykola Kolesnyk, null David, C. Wheeler, Rodolfo Andres Ahuad Guerrero, Juan Pablo Albisu, Andres Alvarisqueta, Ines Bartolacci, Mario Alberto Berli, Anselmo Bordonava, Pedro Calella, Maria Cecilia Cantero, Luis Rodolfo Cartasegna, Esteban Cercos, Gabriela Cecilia Coloma, Hugo Colombo, Victor Commendatore, Jesus Cuadrado, Carlos Alberto Cuneo, Ana Maria Cusumano, Walter Guillermo Douthat, Ricardo Dario Dran, Eduardo Farias, Maria Florencia Fernandez, Hernan Finkelstein, Guillermo Fragale, Jose Osvaldo Fretes, Nestor Horacio Garcia, Anibal Gastaldi, Elizabeth Gelersztein, Jorge Archibaldo Glenny, Joaquin Pablo Gonzalez, Patricia del Carmen Gonzalez Colaso, Claudia Goycoa, Gustavo Cristian Greloni, Adrian Guinsburg, Sonia Hermida, Luis Isaias Juncos, Maria Isabel Klyver, Florencia Kraft, Fernando Krynski, Paulina Virginia Lanchiotti, Ricardo Alfonso Leon de la Fuente, Nora Marchetta, Pablo Mele, Silvia Nicolai, Pablo Antonio Novoa, Silvia Ines Orio, Fabian Otreras, Alejandra Oviedo, Pablo Raffaele, Jorge Hector Resk, Lucas Rista, Nelson Rodriguez Papini, Jorgelina Sala, Juan Carlos Santos, Lilia Beatriz Schiavi, Horacio Sessa, Tomas Smith Casabella, Maria Rosa Ulla, Maria Valdez, Augusto Vallejos, Adriana Villarino, Virginia Esther Visco, Alfredo Wassermann, Cesar Javier Zaidman, Ngai Wah Cheung, Carolyn Droste, Ian Fraser, David Johnson, Peak Mann Mah, Kathy Nicholls, David Packham, Joseph Proietto, Anthony Roberts, Simon Roger, Venessa Tsang, Roberto Abrão Raduan, Fernando Augusto Alves da Costa, Celso Amodeo, Luiz Alberto Andreotti Turatti, Rachel Bregman, Fernanda Cristina Camelo Sanches, Luis Henrique Canani, Antônio Roberto Chacra, João Lindolfo Cunha Borges, Sérgio Alberto Cunha Vêncio, Roberto Jorge da Silva Franco, Domingos d’Avila, Evandro de Souza Portes, Pedro de Souza, Luciane Mônica Deboni, Fadlo Fraige Filho, Bruno Geloneze Neto, Marcus Gomes, Suely Keiko Kohara, Elizete Keitel, Jose Francisco Kerr Saraiva, Hugo Roberto Kurtz Lisboa, Fabiana Loss de Carvalho Contieri, Rosângela Milagres, Renan Montenegro Junior, Claudia Moreira de Brito, Miguel Nasser Hissa, Ângela Regina Nazario Sabbag, Irene Noronha, Daniel Panarotto, Roberto Pecoits Filho, Márcio Antônio Pereira, Wladmir Saporito, Antonio Scafuto Scotton, Tiago Schuch, Roberto Simões de Almeida, Cássio Slompo Ramos, João Soares Felício, Fernando Thomé, Jean Carlo Tibes Hachmann, Sérgio Yamada, Cesar Yoiti Hayashida, Tarissa Beatrice Zanata Petry, Maria Teresa Zanella, Viktoria Andreeva, Angelina Angelova, Stefan Dimitrov, Veselka Genadieva, Gabriela Genova-Hristova, Kiril Hristozov, Zdravko Kamenov, Atanas Koundurdjiev, Lachezar Lozanov, Viktor Margaritov, Boyan Nonchev, Rangel Rangelov, Alexander Shinkov, Margarita Temelkova, Ekaterina Velichkova, Andrian Yakov, Naresh Aggarwal, Ronnie Aronson, Harpreet Bajaj, Guy Chouinard, James Conway, Serge Cournoyer, Gerald DaRoza, Sacha De Serres, François Dubé, Ronald Goldenberg, Anil Gupta, Milan Gupta, Sam Henein, Hasnain Khandwala, Lawrence Leiter, François Madore, Alan McMahon, Norman Muirhead, Vincent Pichette, Remi Rabasa-Lhoret, Andrew Steele, Navdeep Tangri, Ali Torshizi, Vincent Woo, Nadia Zalunardo, María Alicia Fernández Montenegro, Juan Gonzalo Godoy Jorquera, Marcelo Medina Fariña, Victor Saavedra Gajardo, Margarita Vejar, Nan Chen, Qinkai Chen, Shenglian Gan, Yaozhong Kong, Detian Li, Wenge Li, Xuemei Li, Hongli Lin, Jian Liu, Weiping Lu, Hong Mao, Yan Ren, Weihong Song, Jiao Sun, Lin Sun, Ping Tu, Guixia Wang, Jinkui Yang, Aiping Yin, Xueqing Yu, Minghui Zhao, Hongguang Zheng, Jose Luis Accini Mendoza, Edgar Arcos, Jorge Avendano, Jorge Ernesto Andres Diaz Ruiz, Luis Hernando Garcia Ortiz, Alexander Gonzalez, Eric Hernandez Triana, Juan Diego Higuera, Natalia Malaver, Dora Inés Molina de Salazar, Ricardo Rosero, Monica Alexandra Terront Lozano, Luis Valderrama Cometa, Alex Valenzuela, Ruben Dario Vargas Alonso, Ivan Villegas, Hernan Yupanqui, Dagmar Bartaskova, Petr Barton, Jana Belobradkova, Lenka Dohnalova, Tomas Drasnar, Richard Ferkl, Katarina Halciakova, Vera Klokocnikova, Richard Kovar, Jiri Lastuvka, Martin Lukac, Satu Pesickova, Karel Peterka, Jiri Pumprla, Ivan Rychlik, Frantisek Saudek, Vladimir Tesar, Martin Valis, Pavel Weiner, Stanislav Zemek, Eric Alamartine, Sophie Borot, Bertrand Cariou, Bertrand Dussol, Jean-Pierre Fauvel, Pierre Gourdy, Alexandre Klein, Yannick Le Meur, Alfred Penfornis, Ronan Roussel, Pierre-Jean Saulnier, Eric Thervet, Philippe Zaoui, Volker Burst, Markus Faghih, Grit Faulmann, Hermann Haller, Reinhold Jerwan-Keim, Stephan Maxeiner, Björn Paschen, Georg Plassmann, Ludger Rose, Ronaldo Arturo Gonzalez Orellana, Franklin Paul Haase, Juan Pablo Moreira Diaz, Luis Alberto Ramirez Roca, Jose Antonio Sánchez Arenales, José Vicente Sanchez Polo, Erick Turcios Juarez, Gyongyi Csecsei, Botond Csiky, Peter Danos, Laszlo Deak, Mihaly Dudas, Eleonora Harcsa, Katalin Keltai, Sandor Keresztesi, Krisztian Kiss, Laszlo Konyves, Lajos Major, Margit Mileder, Marta Molnar, Janos Mucsi, Tamas Oroszlan, Ivan Ory, Gyorgy Paragh, Eva Peterfai, Gizella Petro, Katalin Revesz, Robert Takacs, Sandor Vangel, Szilard Vasas, Marianna Zsom, Oomman Abraham, Raju Sree Bhushan, Dewan Deepak, Fernando M. Edwin, Natarajan Gopalakrishnan, Noble Gracious, Alva Hansraj, Dinesh Jain, C.B. Keshavamurthy, Dinesh Khullar, Sahay Manisha, Jayameena Peringat, Narayan Prasad, Rao K. Satyanarayana, Reddy Sreedhar, Melemadathil Sreelatha, Bhimavarapu Sudhakar, Ramesh Chandra Vyasam, Riccardo Bonadonna, Pietro Castellino, Antonio Ceriello, Luca Chiovato, Salvatore De Cosmo, Giuseppe Derosa, Alberto Di Carlo, Graziano Di Cianni, Giovanni Frascà, Giorgio Fuiano, Giovanni Gambaro, Giacomo Garibotto, Carlo Giorda, Fabio Malberti, Marcora Mandreoli, Edoardo Mannucci, Emanuela Orsi, Piermarco Piatti, Domenico Santoro, Ferdinando Carlo Sasso, Gaetano Serviddio, Andrea Stella, Roberto Trevisan, Anna Maria Veronelli, Luca Zanoli, Hitoshi Akiyama, Hiromi Aoki, Akimichi Asano, Tadashi Iitsuka, Shizuo Kajiyama, Susumu Kashine, Toshio Kawada, Takamoto Kodera, Hiroshi Kono, Kazunori Koyama, Yasuro Kumeda, Shozo Miyauchi, Kazuyuki Mizuyama, Tetsuji Niiya, Hiroko Oishi, Satoshi Ota, Terue Sakakibara, Masahiko Takai, Osamu Tomonaga, Mitsuru Tsujimoto, Masakiyo Wakasugi, Yasushi Wakida, Takayuki Watanabe, Masayo Yamada, Kazuhiro Yanagida, Toshihiko Yanase, Wataru Yumita, Egle Gaupsiene, Dalia Kozloviene, Antanas Navickas, Egle Urbanaviciene, Rohana Abdul Ghani, Khalid Abdul Kadir, Norsiah Ali, Mohd Daud Che Yusof, Chye Lee Gan, Mastura Ismail, Wei Yen Kong, Swee Win Lam, Li Yuan Lee, Chek Loong Loh, Anita Bhajan Manocha, Kee Sing Ng, Nik Nur Fatnoon Nik Ahmad, Vanassa Ratnasingam, Saiful Shahrizal Bin Shudim, Paranthaman Vengadasalam, Luis David Abraira Munoz, Melchor Alpizar Salazar, Juan Baas Cruz, Mario Burgos Soto, Jose Chevaile Ramos, Alfredo Chew Wong, Jose Ricardo Correa Rotter, Tonatiu Diaz Escalante, Favio Edmundo Enriquez Sosa, Fernando Flores Lozano, Luis Fernando Flota Cervera, Paul Frenk Baron, Cecilia Garcia Ballesteros, Jose David Gomez Rangel, Luis Enrique Herrera Jimenez, Sergio Saul Irizar Santana, Fernando Jimenez Flores, Hugo Laviada Molina, Rosa Isela Luna Ceballos, Belia Martin del Campo Blanco, Guadalupe Morales Franco, Oscar Tarsicio Moreno Loza, Cynthia Mustieles Rocha, Gregorio Obrador Vera, Ricardo Orozco Castellanos, Juan Peralta Calcaneo, Miguel Angel Reyes Rosano, Hiromi Rodriguez Pattzi, Juan Rosas Guzman, Isabel Erika Rucker Joerg, Sandra Berenice Saavedra Sanchez, Jose Hector Sanchez Mijangos, Pablo Serrano Sanson, Juan Alfredo Tamayo y Orozco, Eloisa Tellez Chavez, Alejandro Valdes Cepeda, Luis Venegas Carrillo, Juan Villagordoa Mesa, Rolando Zamarripa Escobedo, John Baker, Paul Noonan, Russell Scott, Robert Walker, Edward Watson, Michael Williams, Simon Young, Zaynab Abejuela, Jeimeen Agra, Grace Aquitania, Clodoaido Caringal, Rhea Severina Comia, Lalaine Delos Santos, Olivert Gomez, Cecilia Jimeno, Gerry Tan, Marsha Tolentino, Christy Yao, Yvette Ethel Yap, Ma. Dovie Lallaine Ygpuara, Renata Bijata-Bronisz, Lucyna Hotlos, Andrzej Januszewicz, Barbara Kaczmarek, Anna Kaminska, Lech Lazuka, Andrzej Madej, Stanislaw Mazur, Dorota Mlodawska-Choluj, Michal Nowicki, Grazyna Orlowska-Kowalik, Grazyna Popenda, Barbara Rewerska, Dariusz Sowinski, Liliana Monica Angelescu, Veronica Anghel, Rodica-Ioana Avram, Mihaela-Magdalena Busegeanu, Adriana Cif, Dana Cosma, Carmen Crisan, Luiza Despina Demian, Ioana Emilia Ferariu, Ildiko Halmagyi, Nicolae Hancu, Mircea Munteanu, Doru Negru, Adriana Gabriela Onaca, Ligia Petrica, Amorin Remus Popa, Aurelian-Emil Ranetti, Cristian Serafinceanu, Cristina Toarba, Alina Agafyina, Olga Barbarash, Olga Barysheva, Daniil Chizhov, Vladimir Dobronravov, Irina Glinkina, Elena Grineva, Vladimir Khirmanov, Elena Kolmakova, Tatiana Koroleva, Liudmila Kvitkova, Viacheslav Marasaev, Ashot Mkrtumyan, Tatiana Morugova, Galina Nagibovich, Oleg Nagibovich, Sergei Nedogoda, Irina Osipova, Tatiana Raskina, Yulia Samoylova, Olga Sazonova, Minara Shamkhalova, Elena Shutemova, Yuriy Shwartz, Oleg Uriasyev, Sergey Vorobyev, Anna Zateyshchikova, Dmitry Zateyshshikov, Tatyana Zykova, Slobodan Antic, Miodrag Djordjevic, Aleksandra Kendereski, Katarina Lalic, Nebojsa Lalic, Vesna Popovic-Radinovic, Jana Babikova, Olga Benusova, Ingrid Buganova, Jan Culak, Andrej Dzupina, Jana Dzuponova, Peter Fulop, Adriana Ilavska, Emil Martinka, Zuzana Ochodnicka, Daniel Pella, Iveta Smatanova, Fayzal Ahmed, Aysha Badat, Johannes Breedt, Lawrence Distiller, Vimladhevi Govender, Ravendran Govender, Mukesh Joshi, Jaco Jurgens, Gulam Latiff, Landman Lombard, Mohamed Mookadam, Nomangesi Ngcakani, Hendrik Nortje, Helena Oosthuizen, Larisha Pillay-Ramaya, Hans Prozesky, Jeevren Reddy, Paul Rheeder, Mary Seeber, Young Min Cho, In-Kyung Jeong, Sin Gon Kim, Yeong Hoon Kim, Hyuk-Sang Kwon, Min Jeong Kwon, Byung-Wan Lee, JungEun Lee, Moon-Kyu Lee, Moon-Suk Nam, Kook-Hwan Oh, Cheol- Young Park, Sun-Hee Park, Kun Ho Yoon, Pere Alvarez Garcia, Luis Asmarats Mercadal, Clara Barrios, Fernando Cereto Castro, Secundino Cigarran Guldris, Marta Dominguez Lopez, Jesus Egido de los Rios, Gema Fernandez Fresnedo, Antonio Galan Serrano, Isabel Garcia, Francisco Javier Gonzalez Martinez, Jose Esteban Jodar Gimeno, Manuel Lopez Mendoza, Tamara Malek Marin, Cristobal Morales Portillo, Maria Antonia Munar Vila, Manuel Muñoz Torres, Javier Nieto Iglesias, Jonay Pantoja Perez, Merce Perez Vera, Jose M. Portoles Perez, María Angustias Quesada Simón, Rafael Simo Canonge, Alfonso Soto Gonzalez, Manel Terns Riera, Francisco Jose Tinahones Madueno, Mercedes Velo Plaza, Chwen-Tzuei Chang, Lee-Ming Chuang, Te-Lin Hsia, Chang-Hsun Hsieh, Chih-Ching Lin, Yung- Chuan Lu, Wayne H-H Sheu, Olga Barna, Svitlana D. Bilyk, Volodymyr Botsyurko, Iryna Dudar, Ivan Fushtey, Olga Godlevska, Oleksandr Golovchenko, Olga Gyrina, Anatoliy Kazmirchuk, Iuliia Komisarenko, Oleksii Korzh, Nonna Kravchun, Oleg Legun, Borys Mankovskyy, Liliya Martynyuk, Yuriy Mostovoy, Nataliia Pashkovska, Larysa Pererva, Tetyana Pertseva, Oleksandr Samoylov, Ivan Smirnov, Yevgeniya Svyshchenko, Halyna Tomashkevych, Ivan Topchii, Nadiya Tryshchuk, Vira Tseluyko, Vadym Vizir, Maryna Vlasenko, Tetiana Zlova, Liliia Zub, Salah Abusnana, Mohamed Railey, Kamal Abouglila, Paul Ainsworth, Zishan Ali, Vijayaraman Arutchelvam, Maria Barnard, Srikanth Bellary, Emyr Davies, Mark Davies, Simon Davies, Alison Dawson, Mohsen El Kossi, Patrick English, Donald Fraser, Luigi Gnudi, Anthony Gunstone, Timothy Hall, Wasim Hanif, Alan Jackson, Andrew Johnson, Franklin Joseph, Singhan Krishnan, Mick Kumwenda, Iain MacDougall, Paul Nixon, Joseph O'Hare, Sam Philip, Shenaz Ramtoola, Manish Saxena, Davesh Sennik, Godwin Simon, Baldev Singh, Jeffrey Stephens, Anna Strzelecka, Rehan Symonds, Wayne Turner, Mona Wahba, John Wakeling, David Wheeler, Peter Winocour, Joseph Abdallah, Raied Abdullah, Matthew Abramowitz, Idalia Acosta, Joseph Aiello, Laura Akright, Ayim Akyea-Djamson, Rajendran Alappan, Radica Alicic, Amer Al-Karadsheh, Dale Crawford Allison, Carlos Arauz-Pacheco, Shahabul Arfeen, Ahmed Arif, Moogali Arvind, Naveen Atray, Ahmed Awad, Peggy Barnhill, Elizabeth Barranco, Carlos Barrera, Matthew Beacom, Venkata Behara, Diogo Belo, Rhonda Bentley-Lewis, Ramon Berenguer, Lidia Bermudez, Marializa Bernardo, Mihaela Biscoveanu, Cynthia Bowman-Stroud, Donald Brandon, Osvaldo Brusco, Robert Busch, Yamil Canaan, Alicia Chilito, Tom Christensen, Cynthia Christiano, Elena Christofides, Caroucel Chuateco, Kenneth Cohen, Robert Cohen, Debbie Cohen-Stein, Charles Cook, Daniel Coyne, Nizar Daboul, Riad Darwish, Adarsh Daswani, Kenneth Deck, Cyrus Desouza, Devasmita Dev, Monika Dhillon, Sohan Dua, Frank Eder, Ana Maria Elosegui, Mohamed El-Shahawy, John Ervin, Alberto Esquenazi, John Evans, Steven Fishbane, Juan Frias, Eugenia Galindo-Ramos, Claude Galphin, Adline Ghazi, Enrique Gonzalez, David Gorson, Anupama Gowda, Barbara Greco, Stephen Grubb, Rakesh Gulati, Jamal Hammoud, Stuart Handelsman, Israel Hartman, Kenneth Hershon, Daniel Hiser, George Hon, Radu Jacob, Maria Jaime, Aamir Jamal, Charles Kaupke, Gerald Keightley, Elizabeth Kern, Rakhi Khanna, Zeid Khitan, Sun Kim, Nelson Kopyt, Csaba Kovesdy, Gopal Krishna, Jeffrey (Jay) Kropp, Amrendra Kumar, Jayant Kumar, Neil Kumar, Jorge Kusnir, Wendy Lane, Mary Lawrence, Lawrence Lehrner, John Lentz, Dennis Levinson, Derek Lewis, Kenneth Liss, Andreas Maddux, Hiralal Maheshwari, Sreedhar Mandayam, Isam Marar, Bhasker Mehta, John Middleton, Jorge Mordujovich, Ramon Moreda, Moustafa Moustafa, Samuel Mujica Trenche, Mohanram Narayanan, Javier Narvarte, Tareq Nassar, George Newman, Brian Nichol, Philip Nicol, Josier Nisnisan, A. Kaldun Nossuli, Chamberlain Obialo, Sarah Olelewe, Michael Oliver, Andrew O'Shaughnessy, John Padron, Rohit Pankhaniya, Reginald Parker, Devesh Patel, Gnyandev Patel, Nina Patel, Humberto Pavon, Armando Perez, Carlos Perez, Alan Perlman, Karlton Pettis, Walter Pharr, Andrea Phillips, Raman Purighalla, Luis Quesada-Suarez, Rajiv Ranjan, Sanjeev Rastogi, Jakkidi Reddy, Marc Rendell, Lisa Rich, Michael Robinson, Hector Rodriguez, Sylvia Rosas, Fadi Saba, Rallabhandi Sankaram, Ravi Sarin, Robert Schreiman, David Scott, Mohamed Sekkarie, John Sensenbrenner, Muhammad Shakeel, Michael Shanik, Sylvia Shaw, Stephen Smith, Richard Solomon, Amy Sprague, Leslie Spry, Pusadee Suchinda, Senan Sultan, Prasanth Surampudi, Sherry Sussman, Anjanette Tan, Antonio Terrelonge, Michael Thompson, Fernando Trespalacios, Bruce Trippe, Pilar Trueba, Marcel Twahirwa, John Updegrove, Peter Van Buren, Mark Vannorsdall, Freemu Varghese, Pedro Velasquez-Mieyer, Sailaja Ventrapragada, Goga Vukotic, Khurram Wadud, Mark Warren, Henry Watson, Ronald Watts, Daniel Weiner, James Welker, Jean Welsh, Shelley Williams, and Michelle Zaniewski-Singh

Subjects
age, diabetes, Nephrology, kidney outcomes, sex, Diabetic kidney disease, canagliflozin, cardiovascular outcomes, chronic kidney disease, sodium/glucose cotransporter 2 inhibitors
Abstract

Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kidney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a randomized controlled trial.Setting & Participants: Participants in the CREDENCE trial.Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kidney failure, doubling of serum creatinine concentration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Outcomes were evaluated by age at baseline (Results: The mean age of the cohort was 63.0 ± 9.2 years, and 34% were female. Older age and female sex were independently associated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (a composite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.48-0.82], and 0.89 [0.61-1.29] for ages Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791.

Published
2023
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20. ESD with double-balloon endoluminal intervention platform versus standard ESD for management of colon polyps

Author

Mohamed Saleh Ismail, Firas Bahdi, Michael Oliver Mercado, Randa Habazi, Angel Alexander, Sahana Prabhu, Sharon John, Chandra Kovvali, and Mohamed O. Othman

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and study aims Endoscopic submucosal dissection (ESD) with the double-balloon endoluminal intervention platform (DEIP) is a novel technique for removal of complex colon polyps (> 2 cm) or those located in anatomically difficult positions. DEIP helps create a therapeutic zone with improved visualization and stability, facilitating polyp removal. We aimed to compare the outcomes of DEIP with the conventional cap-assisted ESD (standard ESD) technique for colon polyp resection, in particular, the ability to complete the ESD procedure without resorting to hybrid ESD or piecemeal resection. Patients and methods This was a retrospective cohort of all patients who underwent colon ESD in a single large tertiary referral center between September 2016 and October 2019. Information was collected on patient demographics and study outcomes including procedure time, rates of en bloc and curative resection, operative and postoperative complications. All patients were followed up for 1 month after the procedure. Results 111 patients were included in the study (DEIP 60, standard ESD 51). There was no statistically significant difference between mean procedures time (± SD) in the two groups, mean (81.9 ± 35.4 min standard vs. 96.4 ± 42.2 min in DEIP). Mean polyp size (± SD) was similar between the two groups (7.6 ± 6.0 cm2 vs. 6.2 ± 5.5 cm2, P = .2). There were no significant differences in en bloc and curative resection rates or operative and postoperative complications between the two techniques. Conclusion Procedure time was similar using both techniques. However, DEIP enabled the entire procedure to be performed using the ESD technique without resorting to snare resection, which may affect the en bloc and curative resection rate. There were no significant differences in en bloc and curative resection rates between the two groups, probably due to the small sample size.

Published
2020
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22. Planning Trade-offs for SABR in Patients With 4 to 10 Metastases: A Substudy of the SABR-COMET-10 Randomized Trial

Author

Samaher Ashram, Houda Bahig, Aisling Barry, Denise Blanchette, Anders Celinksi, Peter Chung, Johnson Darko, David Donath, Robert Doucet, Abigail Erickson, Meredith Giuliani, Darin Gopaul, Scott Hipwell, Joanna Javor, Joda Kuk, Patricia Lindsay, Barbara Millman, Michael Oliver, Andrew Pearce, Catherine Russell, Sashendra Senthi, Toni Vu, Andrew Warner, Stewart Gaede, and David A. Palma

Subjects
Cancer Research, Radiation, Oncology, Humans, Radiology, Nuclear Medicine and imaging, Dose Fractionation, Radiation, Radiosurgery
Published
2022
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23. First volumetric body mass estimate and a new in vivo 3D reconstruction of the oldest Karoo pareiasaur Bradysaurus baini, and body size evolution in Pareiasauria.

Author

Van den Brandt, Marc Johan, Day, Michael Oliver, Manucci, Fabio, Viglietti, Pia Alexa, Angielczyk, Kenneth David, and Romano, Marco

Subjects
*BODY size, *PALEOBIOLOGY, *BODY weight, *TETRAPODS, *SKELETON, PANGAEA (Supercontinent)
Abstract

Pareiasaurs were among the world's first large terrestrial tetrapods, first appearing during the Guadalupian Epoch, and were later widespread across Pangea during the Lopingian where they formed a significant part of the large herbivore guild. The Bradysauria of the Lower Beaufort Group of the Karoo Basin of South Africa are among the oldest pareiasaurs, yet little is known of their palaeobiology. Here, we present the first volumetric body mass estimate and a new in vivo reconstruction of the earliest Karoo pareiasaur, and the phylogenetically basal-most pareiasaur, Bradysaurus baini, based on two almost complete adult mounted skeletons. Using 3D photogrammetric models of the two skeletons, we calculated a possible body mass range for B. baini by applying different densities for living tissue to reconstructions of differing soft tissue mass. Considering the larger adult Bradysaurus specimen, our volumetric body masses range from a minimum of 851.4 kg to a maximum of 1,276.5 kg, with an overall mean body mass of 1,022 kg, approximately the body weight of a large domestic cow. The study provides a more precise estimate of body mass in early members of Pareiasauridae, and we suggest that they were somewhat smaller than some late Permian taxa such as Scutosaurus karpinskii. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Limited Effects of SARS-CoV-2 Pandemic-related Lockdowns and Reduced Population Mobility on Preterm Birth Rates: A Secondary Analysis of Bavarian Obstetric Quality Parameters from 2010 to 2020

Author

Florian Matthias, Stumpfe, Michael Oliver, Schneider, Alexander, Hein, Florian, Faschingbauer, Sven, Kehl, Peter, Hermanek, Julian, Böhm, Anton, Scharl, Matthias Wilhelm, Beckmann, Christian, Staerk, and Andreas, Mayr

Subjects
Maternity and Midwifery, Obstetrics and Gynecology
Abstract

Introduction International studies on preterm birth rates during COVID-19 lockdowns report different results. This study examines preterm birth rates during lockdown periods and the impact of the mobility changes of the population in Bavaria, Germany. Material and Methods This is a secondary analysis of centrally collected data on preterm births in Bavaria from 2010 to 2020. Preterm births ( Results Unadjusted preterm birth rates in 2020 were significantly lower for singleton pregnancies during the two lockdown periods (Lockdown 1: 5.71% vs. 6.41%; OR 0.88; p Conclusions Reduced preterm birth rates during both lockdown periods in 2020 were observed for singleton and twin pregnancies. However, these effects are reduced when adjusting for long-term and seasonal trends. Reduced population mobility was associated with lower preterm birth rates in twin pregnancies.

Published
2022
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29. COMPARING THROUGH-THE-SCOPE HELIX TACK AND SUTURE DEVICE (TTSS) WITH THROUGH-THE-SCOPE CLIPS (TTSC) IN MUCOSAL DEFECT CLOSURE FOLLOWING COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD): A PROPENSITY SCORE-MATCHED ANALYSIS

Author

Farha, Jad, primary, Othman, Mohamed, additional, Jawaid, Salmaan, additional, Schlachterman, Alexander, additional, Kumar, Anand, additional, Friedland, Shai, additional, Storm, Andrew, additional, Yang, Dennis, additional, Hasan, Muhammad, additional, Mercado, Michael Oliver, additional, Khan, Adnan, additional, Sayegh, Lea, additional, Arayakarnkul, Suchapa, additional, Tolosa, Celestina, additional, Inal, Ekin, additional, Berrien-Lopez, Rickisha, additional, Tsay, Cynthia, additional, Hiroyuki, Aihara, additional, and Ngamruengphong, Saowanee, additional

Published
2023
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31. ENDOSCOPIC SUBMUCOSAL DISSECTION OF ESOPHAGEAL ADENOCARCINOMA DEEMED PATHOLOGICALLY CURATIVE RESULTS IN FEW RECURRENCES AT LONG-TERM SURVEILLANCE: A NORTH AMERICAN STUDY

Author

Schenck, Robert, primary, Bhatt, Amit, additional, Ngamruengphong, Saowanee, additional, Friedland, Shai, additional, Aihara, Hiroyuki, additional, Dewitt, John, additional, Patrie, James, additional, Foster, Sharon, additional, Joseph, Abel, additional, Arayakarnkul, Suchapa, additional, Mercado, Michael Oliver, additional, Northern, Nathan, additional, Aadam, A. Aziz, additional, Othman, Mohamed, additional, Sethi, Amrita, additional, Sharaiha, Reem, additional, Nishimura, Makoto, additional, Fukami, Norio, additional, Hwang, Joo Ha, additional, Yang, Dennis, additional, Draganov, Peter, additional, and Wang, Andrew, additional

Published
2023
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33. Pharmacovigilance, a blind spot in future prescribers: Is real-life clinical pharmacovigilance education a solution?

Author

Reumerman, Michael Oliver and Reumerman, Michael Oliver

Abstract

Current situation Conclusions: While pharmacovigilance and ADR reporting are considered relevant for future healthcare professionals, healthcare students currently lack appropriate pharmacovigilance knowledge and skills for these tasks. This is probably because they have had inadequate and or insufficient pharmacovigilance education during their training. Although only a few high-quality educational interventions have been described, the competencies learned with these educational interventions appear to fade quickly. Active learning techniques, such as enriched pharmacovigilance education or providing students with responsibility for an authentic and clinical task, could be a more effective way of teaching and increasing the pharmacovigilance competence of healthcare students. Recommendations: In order to improve the pharmacovigilance and ADR reporting competencies of future healthcare professionals, pharmacovigilance education should be developed using active learning techniques, such as a maximally enriched (pharmacovigilance) educational context, and evaluated. Real-life clinical practice Conclusions: Real-life pharmacovigilance education seems more effective than traditional education and has a positive influence on pharmacovigilance in clinical care. Healthcare students who had reported or assessed ADRs themselves had a more favourable attitude to ADR reporting and had more and longer-lasting pharmacovigilance skills and knowledge. By participating in this learning opportunity, they also contributed to pharmacovigilance in individual patient care and thereby increased medication safety. Recommendations: Incorporating real-life pharmacovigilance educational interventions in bachelor degrees and replacing aspects of current clerkships/internships should be seriously considered. Moreover, these interventions should involve students from different healthcare disciplines working in an interprofessional team. Real-life interprofessional practice Conclusions: Interpr

Published
2023
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35. James Baldwin and the 'Lie of Whiteness': Toward an Ethic of Culpability, Complicity, and Confession

Author

Michael Oliver

Subjects
religious ethics, racism, African American religion, confession, whiteness, James Baldwin, Religions. Mythology. Rationalism, BL1-2790
Abstract

This article is an attempt to draw on James Baldwin’s depiction of white identity as the “the lie of whiteness” to tease out a nascent ethics that centers the role of genuine, honest confrontation with this so-called “lie.” In order to connect the dots between excavation of Baldwin’s lie of whiteness and the provinces of religious ethics, we will explore the role that truth-telling plays in the form of something like a religious notion of confession, limiting our engagement with confession to an honest and genuine encounter with culpability and responsibility through truth-telling. The analysis will be guided by several questions: how might a genuine reckoning with the reality and prevalence of what Baldwin intimately describes about whiteness and its connection to anti-black racism be understood morally? How might this confrontation with the truth be understood in relation to a religious concept like confession, as defined above? Finally, how might this process of confrontation further expose the machinations of Baldwin’s “lie of whiteness” and, in so doing, offer an ethical response that includes culpability and complicity? In so doing, this article seeks to begin sketching out an ethics of the role of confession in the struggle against the evils of anti-black racism, through direct engagement with Baldwin’s description of the “lie of whiteness.”

Published
2021
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36. Game Mastering in Collaborative Serious Games: A Novel Approach for Instructor Support in Multiplayer Serious Games

Author

Wendel, Viktor, Krepp, Stefan, and Gutjahr, Michael Oliver

Abstract

In collaborative learning scenarios, the role of the instructor is vital. This aspect directly carries over to the concept of collaborative multiplayer Serious Games, where a group of players is learning together using a Serious Game. In this paper, the authors propose a novel approach for integration and support of instructors in collaborative multiplayer Serious Game scenarios. Their approach considers instructor tasks and responsibilities. It defines an interface for 3D action adventure-like games, defining relevant game information and adaptation access. It further includes a Game Mastering framework for orchestrating and adapting such games at runtime via an instructor. The concept was implemented on top of an existing Serious Game (Escape from Wilson Island) and evaluated in a user-centric study with N = 40 participants (age m = 23.39; SD = 3.05). Results show that an instructor using our framework in a collaborative learning scenario can positively influence players' game experience (p<0.05) and success towards the intended goals, as well as recognize and counteract problems at runtime.

Published
2015
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39. Validating the accuracy of a novel virtual reality platform for determining implant orientation in simulated primary total hip replacement

Author

Daniel Howgate, Michael Oliver, Julie Stebbins, Patrick Garfjeld Roberts, Ben Kendrick, Jonathan Rees, and Stephen Taylor

Subjects
Health Information Management, Health Policy, Health Informatics, Computer Science Applications
Abstract

Introduction Accurate acetabular cup and femoral stem component orientation are critical for optimising patient outcomes, reducing complications and increasing component longevity following total hip replacement (THR). This study aimed to determine the accuracy of a novel virtual reality (VR) platform in assessing component orientation in a simulated THR model. Methods The VR platform (HTC Vive Pro® system hardware) was compared against the validated Vicon® optical motion capture (MoCap) system. An acetabular cup and femoral stem were manually implanted across a range of orientations into pelvic and femur sawbones, respectively. Simultaneous readings of the acetabular cup operative anteversion (OA) and inclination (OI) and femoral stem alignment (FSA) and neck anteversion (FNA) were obtained from the VR and MoCap systems. Statistical analysis was performed using Pearson product-moment correlation coefficient (PPMCC) (Pearson’s r) and linear regression (R2). Results A total of 55 readings were obtained for the acetabular cup and 68 for the femoral stem model. The mean average differences in OA, OI, FSA and FNA between the systems were 3.44°, −0.01°, 0.01° and −0.04°, respectively. Strong positive correlations were demonstrated between both systems in OA, OI, FSA and FNA, with Pearson’s r = 0.92, 0.94, 0.99 and 0.99, and adjusted R2 = 0.82, 0.9, 0.98 and 0.98, respectively. Conclusion The novel VR platform is highly accurate and reliable in determining both acetabular cup and femoral stem component orientations in simulated THR models. This adaptable and cost-effective digital tracking platform may be modified for use in a range of simulated surgical training and educational purposes, particularly in orthopaedic surgery.

Published
2023

40. Stimulus novelty uncovers coding diversity in visual cortical circuits

Author

Marina Garrett, Peter Groblewski, Alex Piet, Doug Ollerenshaw, Farzaneh Najafi, Iryna Yavorska, Adam Amster, Corbett Bennett, Michael Buice, Shiella Caldejon, Linzy Casal, Florence D’Orazi, Scott Daniel, Saskia EJ de Vries, Daniel Kapner, Justin Kiggins, Jerome Lecoq, Peter Ledochowitsch, Sahar Manavi, Nicholas Mei, Christopher B. Morrison, Sarah Naylor, Natalia Orlova, Jed Perkins, Nick Ponvert, Clark Roll, Sam Seid, Derric Williams, Allison Williford, Ruweida Ahmed, Daniel Amine, Yazan Billeh, Chris Bowman, Nicholas Cain, Andrew Cho, Tim Dawe, Max Departee, Marie Desoto, David Feng, Sam Gale, Emily Gelfand, Nile Gradis, Conor Grasso, Nicole Hancock, Brian Hu, Ross Hytnen, Xiaoxuan Jia, Tye Johnson, India Kato, Sara Kivikas, Leonard Kuan, Quinn L’Heureux, Sophie Lambert, Arielle Leon, Elizabeth Liang, Fuhui Long, Kyla Mace, Ildefons Magrans de Abril, Chris Mochizuki, Chelsea Nayan, Katherine North, Lydia Ng, Gabriel Koch Ocker, Michael Oliver, Paul Rhoads, Kara Ronellenfitch, Kathryn Schelonka, Josh Sevigny, David Sullivan, Ben Sutton, Jackie Swapp, Thuyanh K Nguyen, Xana Waughman, Joshua Wilkes, Michael Wang, Colin Farrell, Wayne Wakeman, Hongkui Zeng, John Phillips, Stefan Mihalas, Anton Arkhipov, Christof Koch, and Shawn R Olsen

Abstract

The detection of novel stimuli is critical to learn and survive in a dynamic environment. Though novel stimuli powerfully affect brain activity, their impact on specific cell types and circuits is not well understood. Disinhibition is one candidate mechanism for novelty-induced enhancements in activity. Here we characterize the impact of stimulus novelty on disinhibitory circuit components using longitudinal 2-photon calcium imaging of Vip, Sst, and excitatory populations in the mouse visual cortex. Mice learn a behavioral task with stimuli that become highly familiar, then are tested on both familiar and novel stimuli. Mice consistently perform the task with novel stimuli, yet responses to stimulus presentations and stimulus omissions are dramatically altered. Further, we find that novelty modifies coding of visual as well as behavioral and task information. At the population level, the direction of these changes is consistent with engagement of the Vip-Sst disinhibitory circuit. At the single cell level, we identify separate clusters of Vip, Sst, and excitatory cells with unique patterns of novelty-induced coding changes. This study and the accompanying open-access dataset reveals the impact of novelty on sensory and behavioral representations in visual cortical circuits and establishes novelty as a key driver of cellular functional diversity.

Published
2023
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41. Pharmacovigilance, a blind spot in future prescribers

Author

Reumerman, Michael Oliver, van Agtmael, Michiel, Richir, Milan, Tichelaar, Jelle, Internal medicine, van Agtmael, M.A., Richir, Milan Christian, and VUmc - School of Medical Sciences

Subjects
Pharmacovigilance, Real-life onderwijs, Medicatie veiligheid, Farmacovigilantie, Onderwijs, SDG 4 - Quality Education, Real-life education, Education, Medication safety
Abstract

Current situation Conclusions: While pharmacovigilance and ADR reporting are considered relevant for future healthcare professionals, healthcare students currently lack appropriate pharmacovigilance knowledge and skills for these tasks. This is probably because they have had inadequate and or insufficient pharmacovigilance education during their training. Although only a few high-quality educational interventions have been described, the competencies learned with these educational interventions appear to fade quickly. Active learning techniques, such as enriched pharmacovigilance education or providing students with responsibility for an authentic and clinical task, could be a more effective way of teaching and increasing the pharmacovigilance competence of healthcare students. Recommendations: In order to improve the pharmacovigilance and ADR reporting competencies of future healthcare professionals, pharmacovigilance education should be developed using active learning techniques, such as a maximally enriched (pharmacovigilance) educational context, and evaluated. Real-life clinical practice Conclusions: Real-life pharmacovigilance education seems more effective than traditional education and has a positive influence on pharmacovigilance in clinical care. Healthcare students who had reported or assessed ADRs themselves had a more favourable attitude to ADR reporting and had more and longer-lasting pharmacovigilance skills and knowledge. By participating in this learning opportunity, they also contributed to pharmacovigilance in individual patient care and thereby increased medication safety. Recommendations: Incorporating real-life pharmacovigilance educational interventions in bachelor degrees and replacing aspects of current clerkships/internships should be seriously considered. Moreover, these interventions should involve students from different healthcare disciplines working in an interprofessional team. Real-life interprofessional practice Conclusions: Interprofessional healthcare teams, learning from and with each other, can contribute to pharmacovigilance in clinical practice by detecting and managing ADRs in real patients. In addition, students have their first opportunity to work in an interprofessional manner and thereby gain insight into the perspectives and qualities of their future colleagues. Recommendations: Although the value of interprofessional education is increasingly appreciated, curricula should try to ensure that students work on clinically relevant, real-life (pharmacovigilance) care. Future intervention studies should further unravel the learning benefits of real-life interprofessional education.

Published
2023
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44. Removing independent noise in systems neuroscience data using DeepInterpolation

Author

Christof Koch, Peter Ledochowitsch, Michael Oliver, Natalia Orlova, Jérôme Lecoq, and Joshua H. Siegle

Subjects
Computer science, Noise reduction, Action Potentials, Neuroimaging, Signal-To-Noise Ratio, computer.software_genre, Multimodal Imaging, Biochemistry, Noise (electronics), Mice, Voxel, Image Processing, Computer-Assisted, Animals, Humans, Molecular Biology, Neurons, Ground truth, Quantitative Biology::Neurons and Cognition, business.industry, Deep learning, Shot noise, Pattern recognition, Cell Biology, Magnetic Resonance Imaging, Microscopy, Fluorescence, Multiphoton, Temporal resolution, Calcium, Artificial intelligence, business, Raw data, computer, Algorithms, Biotechnology
Abstract

Progress in many scientific disciplines is hindered by the presence of independent noise. Technologies for measuring neural activity (calcium imaging, extracellular electrophysiology and functional magnetic resonance imaging (fMRI)) operate in domains in which independent noise (shot noise and/or thermal noise) can overwhelm physiological signals. Here, we introduce DeepInterpolation, a general-purpose denoising algorithm that trains a spatiotemporal nonlinear interpolation model using only raw noisy samples. Applying DeepInterpolation to two-photon calcium imaging data yielded up to six times more neuronal segments than those computed from raw data with a 15-fold increase in the single-pixel signal-to-noise ratio (SNR), uncovering single-trial network dynamics that were previously obscured by noise. Extracellular electrophysiology recordings processed with DeepInterpolation yielded 25% more high-quality spiking units than those computed from raw data, while DeepInterpolation produced a 1.6-fold increase in the SNR of individual voxels in fMRI datasets. Denoising was attained without sacrificing spatial or temporal resolution and without access to ground truth training data. We anticipate that DeepInterpolation will provide similar benefits in other domains in which independent noise contaminates spatiotemporally structured datasets. DeepInterpolation is a self-supervised deep learning-based denoising approach for calcium imaging, electrophysiology and fMRI data. The approach increases the signal-to-noise ratio and allows extraction of more information from the processed data than from the raw data.

Published
2021
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