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225 results on '"Miccichè F"'

1. PO-1193 Pattern of practice in elderly patients with HPV positive oropharyngeal cancer: a multicenter study

Author

Bonomo, P., primary, Romei, A., additional, Salvestrini, V., additional, Doccioli, C., additional, Belgioia, L., additional, Maddalo, M., additional, Fanetti, G., additional, De Franco, P., additional, Bertocci, S., additional, De Felice, F., additional, Ursino, S., additional, Merlotti, A., additional, Alterio, D., additional, Iacovelli, A.N., additional, Miccichè, F., additional, D'Angelo, E., additional, Becherini, C., additional, Desideri, I., additional, Caini, S., additional, and Livi, L., additional

Published
2023
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3. PD-0827 Dose volume correlates of mouth opening reduction after radiotherapy for HNC: comprehensive analysis

Author

Massaccesi, M., primary, Fuga, V., additional, Dinapoli, N., additional, Rupe, C., additional, Olivieri, M., additional, Beghella Bartoli, F., additional, Mazzarella, C., additional, Panfili, M., additional, Calandrelli, R., additional, Settimi, S., additional, Lajolo, C., additional, Gambacorta, M.A., additional, and Miccichè, F., additional

Published
2022
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7. PO-0842: PRO.M.E.THE.O.: the development of an italian multicentric OS predictive model in oropharynx cancer

Author

Miccichè, F., primary, Chiloiro, G., additional, Longo, S., additional, Bonomo, P., additional, Bacigalupo, A., additional, Merlotti, A., additional, D'angelo, E., additional, Franco, P., additional, Belgioia, L., additional, Desideri, I., additional, Denaro, N., additional, Meduri, B., additional, Arcadipane, F., additional, Lenkowicz, J., additional, Pesce, A., additional, Autorino, R., additional, Massaccesi, M., additional, and Valentini, V., additional

Published
2020
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17. PO-0618: Role of PET in radiotherapy planning of head and neck tumors: a systematic review

Author

Ferioli, M., primary, Farioli, A., additional, Cellini, F., additional, Arcelli, A., additional, Sandler, I., additional, Cilla, S., additional, Deodato, F., additional, Macchia, G., additional, Cammelli, S., additional, Guido, A., additional, Romani, F., additional, Angelini, A., additional, Compagnone, G., additional, Miccichè, F., additional, Frakulli, R., additional, Buwenge, M., additional, Marengo, M., additional, Valentini, V., additional, Fanti, S., additional, and Morganti, A.G., additional

Published
2017
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21. Sphincter Preservation in Four Consecutive Phase II Studies of Preoperative Chemoradiation: Analysis of 247 T3 Rectal Cancer Patients

Author

Gambacorta, M. A., Valentini, V., Coco, C., Manno, A., Doglietto, G. B., Ratto, C., Maurizio Cosimelli, Miccichè, F., Maurizi, F., Tagliaferri, L., Mantini, G., Balducci, M., La Torre, G., Barbaro, B., and Picciocchi, A.

Subjects
Adult, Aged, 80 and over, Male, Cancer Research, Rectal Neoplasms, Anal Canal, General Medicine, Middle Aged, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Antineoplastic Combined Chemotherapy Protocols, Preoperative Care, Humans, Female, Radiotherapy, Adjuvant, Aged
Abstract

Aims and Background To evaluate the impact of preoperative chemoradiation on sphincter preservation in patients with low- medium locally advanced resectable rectal cancer treated by four chemoradiation schedules. Materials and Methods Between 1990 and 2002, 247 patients were treated according to four schedules of chemoradiotherapy: FUMIR (5-fluorouracil, mitomycin, external beam radiotherapy 37.8 Gy), PLAFUR (cisplatinum, 5-fluorouracil, external beam radiotherapy 50.4 Gy), TOMRT (raltitrexed, external beam radiotherapy 50.4 Gy), and TOMOXRT (raltitrexed, oxaliplatin, external beam radiotherapy 50.4 Gy). Four to five weeks after chemoradiation, patients were restaged and surgery was performed 2-3 weeks later. Results Overall, the sphincter-saving surgery was performed in 82.5% of patients. In patients candidate to an abdominoperineal resection before chemoradiaton (distance tumor-anorectal ring, Conclusions Even though the surgeons’ skill in performing sphincter-saving surgery could be improved with time, the high rate of this procedure in the latest schedules suggests an impact of the new drugs in promoting tumor downsizing and therefore sphincter-saving surgery.

Published
2007

22. Radiation therapy of breast cancer. Reasoned approach to a clinical case

Author

Ramella, S, Canadè, A, Arcangeli, S, Miccichè, F, Mangiacotti, M, Mattiucci, G, Valentini, V, Trodella, L, Cellini, N, Ramella S, Canadè A, Arcangeli S, Miccichè F, Mangiacotti M, Mattiucci G, Valentini V, Trodella L, Cellini N, Ramella, S, Canadè, A, Arcangeli, S, Miccichè, F, Mangiacotti, M, Mattiucci, G, Valentini, V, Trodella, L, Cellini, N, Ramella S, Canadè A, Arcangeli S, Miccichè F, Mangiacotti M, Mattiucci G, Valentini V, Trodella L, and Cellini N

Abstract

The case of a patient undergoing quadrantectomy of lower quandrants of the right breast and ipsilateral axillary lymph node dissection for breast cancer followed by adjuvant radiotherapy is discussed. The stage of the disease and prognostic factors are analyzed for prognosis. Comorbidities ruled out chemotherapy. Radiation therapy was planned followed by clinicoinstrumental controls. After the second control ipsilateral costal bone metastases were observed; radiation therapy for palliation was prescribed

Published
2004

23. PARAOXONASE 1 GENE POLYMORPHISMS IN ALZHEIMER DISEASE AND VASCULAR DEMENTIA

Author

Cagnin, A, Lunardelli, V, Moretti, Rita, Briani, C, Gabelli, C, Terrazzino, S, Miccichè, F, Stecca, A, Passarotto, M, Ricchieri, Gl, Pizzolato, G, Leon, A, Battistin, L., Cagnin, A, Lunardelli, V, Moretti, Rita, Briani, C, Gabelli, C, Terrazzino, S, Miccichè, F, Stecca, A, Passarotto, M, Ricchieri, Gl, Pizzolato, G, Leon, A, and Battistin, L.

Published
2006

24. PO-1010: Partial delegation in 2-D match set-up evaluation for H&N IGRT treatment: preliminary results

Author

Alitto, A.R., primary, Pesce, A., additional, Menna, S., additional, Massaccesi, M., additional, Manfrida, S., additional, Pacchiarotti, A., additional, Castelluccia, A., additional, Miccichè, F., additional, Dinapoli, N., additional, Mattiucci, G.C., additional, Autorino, R., additional, Catucci, F., additional, Azario, L., additional, Luzi, S., additional, Valentini, V., additional, and Balducci, M., additional

Published
2016
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25. EP-1038: IMRT/VMAT-SIB technique chemoradiation in locally advanced head and neck cancer: toxicity results

Author

Deodato, F., primary, Cilla, S., additional, Macchia, G., additional, Grifa, F., additional, Torre, G., additional, Nuzzo, M., additional, Mattiucci, G.C., additional, Sallustio, G., additional, Di Lullo, L., additional, Miccichè, F., additional, Tagliaferri, L., additional, Monari, F., additional, Ntreta, M., additional, Parmeggiani, C., additional, Cortesi, A., additional, Farioli, A., additional, Cammelli, S., additional, Frezza, G., additional, Valentini, V., additional, and Morganti, A.G., additional

Published
2016
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26. HPV and EBV Infections in Neck Metastases from Occult Primary Squamous Cell Carcinoma: Another Virus-Related Neoplastic Disease in the Head and Neck Region

Author

Bussu, Francesco, Sali, Michela, Gallus, Roberto, Petrone, Gianluigi, Autorino, Rosa, Santangelo, Rosaria, Pandolfini, Manlio, Miccichè, F, Delogu, Giovanni, Almadori, G, Galli, Jacopo, Sanguinetti, Maurizio, Rindi, Guido, Tommasino, Massimo, Valentini, Vincenzo, Paludetti, Gaetano, Bussu, Francesco (ORCID:0000-0001-6261-2772), Sali, Michela (ORCID:0000-0003-3609-2990), Santangelo, Rosaria (ORCID:0000-0002-8056-218X), Delogu, Giovanni (ORCID:0000-0003-0182-8267), Galli, Jacopo (ORCID:0000-0001-6353-6249), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Rindi, Guido (ORCID:0000-0003-2996-4404), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Bussu, Francesco, Sali, Michela, Gallus, Roberto, Petrone, Gianluigi, Autorino, Rosa, Santangelo, Rosaria, Pandolfini, Manlio, Miccichè, F, Delogu, Giovanni, Almadori, G, Galli, Jacopo, Sanguinetti, Maurizio, Rindi, Guido, Tommasino, Massimo, Valentini, Vincenzo, Paludetti, Gaetano, Bussu, Francesco (ORCID:0000-0001-6261-2772), Sali, Michela (ORCID:0000-0003-3609-2990), Santangelo, Rosaria (ORCID:0000-0002-8056-218X), Delogu, Giovanni (ORCID:0000-0003-0182-8267), Galli, Jacopo (ORCID:0000-0001-6353-6249), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Rindi, Guido (ORCID:0000-0003-2996-4404), and Paludetti, Gaetano (ORCID:0000-0003-2480-1243)

Abstract

Approximately 1-9 % of all head and neck squamous cell carcinomas are neck metastases from clinically undetectable primary tumors. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are proven carcinogenic factors that are associated with oropharyngeal squamous cell carcinoma and nasopharyngeal carcinoma, respectively. In the present study, we evaluated the prevalence of these viruses in neck metastases from unknown primary squamous cell carcinoma.

Published
2015

27. Role of (18)F-FDG PET-CT in head and neck squamous cell carcinoma

Author

Castaldi P, Leccisotti L, Bussu F, Miccichè F, and vittoria rufini

Subjects
Radiotherapy Planning, Computer-Assisted, Squamous cell, PET-CT, Carcinoma, Review Article, Multimodal Imaging, 18F-FDG, Head and neck tumours, Fluorodeoxyglucose F18, Head and Neck Neoplasms, Positron-Emission Tomography, Carcinoma, Squamous Cell, Humans, Radiopharmaceuticals, Tomography, X-Ray Computed, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Neoplasm Staging
Abstract

The role of PET-CT imaging in head and neck squamous cell carcinoma during pre-treatment staging, radiotherapy planning, treatment response assessment and post-therapy follow-up is reviewed with focus on current evidence, controversial issues and future clinical applications. In staging, the role of (18)F-FDG PET-CT is well recognized for detecting cervical nodal involvement as well as for exclusion of distant metastases and synchronous primary tumours. In the evaluation of treatment response, the high negative predictive value of (18)F-FDG PET-CT performed at least 8 weeks from the end of radio-chemotherapy allows prevention of unnecessary diagnostic invasive procedures and neck dissection in many patients, with a significant impact on clinical outcome. On the other hand, in this setting, the low positive predictive value due to possible post-radiation inflammation findings requires special care before making a clinical decision. Controversial data are currently available on the role of PET imaging during the course of radio-chemotherapy. The prognostic role of (18)F-FDG PET-CT imaging in head and neck squamous cell carcinoma is recently emerging, in addition to the utility of this technique in evaluation of the tumour volume for planning radiation therapy. Additionally, new PET radiopharmaceuticals could provide considerable information on specific tumour characteristics, thus overcoming the limitations of (18)F-FDG.In questa review è analizzato il ruolo della PET-CT nei carcinomi squamosi del distretto testa-collo in fase di stadiazione, nella pianificazione del trattamento radiante, nella valutazione della risposta al trattamento radio-chemioterapico e nel follow-up, tenendo conto dei dati attualmente disponibili, delle questioni controverse e delle future applicazioni cliniche. In fase di stadiazione, è ampiamente riconosciuto il ruolo della PET-CT con

Published
2012

28. SPIDER: Managing Clinical Data of Cancer Patients Treated through a Multidisciplinary Approach by a Palm Based System

Author

Vincenzo Valentini, Maurizi, F., Tagliaferri, L., Balducci, M., Cellini, F., Gambacorta, M. A., Lanzotti, V., Manfrida, S., Mantini, G., Mattiucci, G. C., Meduri, B., Miccichè, F., Nardone, L., and D Agostino, G. R.

Subjects
lcsh:Public aspects of medicine, Electronic medical record, lcsh:R, Personal digital assistant, lcsh:Medicine, lcsh:RA1-1270, Health information technology, health information technology, electronic medical record, data sharing, personal digital, DOAJ:Public Health, Multi-disciplinary cancer care, Data sharing, DOAJ:Health Sciences, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Abstract

Background: The complexity of modern oncology, based on multi-disciplinary management of cancer patients, results in critical amounts of data, leading to problems in managing and sharing information.Methods: Spider is a multi-user system, based on integrated palm technology, created to facilitate data recording, managing and sharing, through Intra-Internet connection. By palms or PCs, data are collected directly at the place where information is generated. Every health professional can edit, modify and display all of the patient's data according to his/her operational level. A powerful engine enables Spider’s users to create series of cancer patients’ appointments linked to one another by specified time intervals and save them as “Protocols”. Applying a protocol to the patient, the system schedules a wave of appointments and alerts keeping the correlation with time intervals previously specified by specialists. XML technology is integrated with traditional RDBMS technology to build the Electronic Patient File (EPF) updated during each patient’s admission or consultation, including any new diagnostic/therapeutic events and collective decisions. The system automatically produces all clinical documents routinely in use (discharge letters, exams’ requests, etc.).Results: Spider’s different archives include 4387 patients (Prostate, n=849; Lung, n=1596; Rectum, n=1541; Head & Neck, n=291; Cervix, n=110). The EPF includes specific modules: staging, surgery, chemotherapy, hormonotherapy, radiotherapy, toxicity, pathology, follow-up and clinical summary. Spider Hospitalization displays the ward map and important details of patients occupying each single bed. Conclusions: Spider makes data capture easier and accurate. The availability of large amounts of information accelerates outcome analysis and improves cancer research.

Published
2012

30. PO-1030: COBRA ontology: a proposal for a standardized data collection (SDC) for H&N patients treated with brachytherapy

Author

Tagliaferri, L., primary, Kovács, G., additional, Budrukkar, A., additional, Autorino, R., additional, Gatta, R., additional, Dinapoli, N., additional, Lanzotti, V., additional, Miccichè, F., additional, Gambacorta, M.A., additional, Damiani, A., additional, Bussu, F., additional, Paludetti, G., additional, and Valentini, V., additional

Published
2015
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31. Adverse skin reactions during treatment with cetuximab plus radiotherapy: Multidisciplinary approach to minimize radio-chemotherapy interruption

Author

Ricci, F, Paradisi, A, Silveri, Sl, Sampogna, F, Miccichè, F, Bonomo, Pl, Dinapoli, N, Valentini, Vincenzo, Capizzi, Rodolfo, Guerriero, C., Capizzi, Rodolfo (ORCID:0000-0001-6149-9237), Ricci, F, Paradisi, A, Silveri, Sl, Sampogna, F, Miccichè, F, Bonomo, Pl, Dinapoli, N, Valentini, Vincenzo, Capizzi, Rodolfo, Guerriero, C., and Capizzi, Rodolfo (ORCID:0000-0001-6149-9237)

Abstract

Background: Antibodies against the epidermal growth factor receptor (EGFR), such as cetuximab, are effective in loco-regional advanced squamous cell carcinoma of the head and neck (SCCHN) in association with radiotherapy. Cutaneous reactions are well known as adverse events during treatment with EGFR inhibitors. Objective: To identify a multidisciplinary approach for mucous-cutaneous toxicity during cetuximab-radiotherapy treatment in order to reduce the risk of an early radio-chemotherapy interruption. Methods: The data of 38 patients with SCCHN receiving cetuximab and radiotherapy were retrospectively analyzed. The control group (n = 15) received the standardized treatments according to the severity of skin reactions with dermatologic visits only for high degrees of toxicity. The experimental group (n = 23) was monitored and daily treated by dermatologists since grade 1 of cutaneous toxicity. The primary end-point of our study was the mean days of antitumor therapy interruption. Results: The mean number of days of antitumor therapy suspension was 12.6 (7.6) in the standard treatment group and 5.0 (6.6) in the experimental group (p = 0.002). This difference was observed for each grade of toxicity. Conclusion: The early interruption of radio-chemotherapy has a negative impact on survival in patients with SCCHN. In our study, a closer dermatological examination and treatment for all degrees of toxicity reduced early interruptions of chemo-radiotherapy.

Published
2014

42. Comparison of total laryngectomy with surgical (cricohyoidopexy) and nonsurgical organ-preservation modalities in advanced laryngeal squamous cell carcinomas: A multicenter retrospective analysis

Author

Bussu, Francesco, Paludetti, Gaetano, Almadori, Giovanni, De Virgilio, A, Galli, Jacopo, Miccichè, F, Tombolini, M, Rizzo, Davide, Gallo, Adele, Giglia, Veronica, Greco, Alessandro, Valentini, Viola, De Vincentiis, M., Bussu, Francesco (ORCID:0000-0001-6261-2772), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Almadori, Giovanni (ORCID:0000-0002-4605-2442), Galli, Jacopo (ORCID:0000-0001-6353-6249), Bussu, Francesco, Paludetti, Gaetano, Almadori, Giovanni, De Virgilio, A, Galli, Jacopo, Miccichè, F, Tombolini, M, Rizzo, Davide, Gallo, Adele, Giglia, Veronica, Greco, Alessandro, Valentini, Viola, De Vincentiis, M., Bussu, Francesco (ORCID:0000-0001-6261-2772), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Almadori, Giovanni (ORCID:0000-0002-4605-2442), and Galli, Jacopo (ORCID:0000-0001-6353-6249)

Abstract

BACKGROUND: Functional outcome and quality of life (QOL) have become relevant endpoints in the field of laryngeal oncology, leading to the emergence of organ-preserving strategies. METHODS: The medical records of 166 patients with advanced (stages III and IV) laryngeal squamous cell carcinoma (SCC) who were treated with a total laryngectomy, radiochemotherapy, or cricohyoidopexy (CHP) were reviewed. RESULTS: In the whole series, no statistically significant differences among the 3 treatment arms with respect to the overall survival (OS) and disease-specific survival (DSS) rates were observed. The organ-preservation rate was 45% for radiotherapy and 76.7% for CHP (p = .0002). Among the cT4a cases, a longer survival was observed for the patients treated with total laryngectomy (3 yr-OS = 78% vs 68% for CHP and 54% for radiochemotherapy, p = .031). CONCLUSIONS: In advanced laryngeal SCC, CHP shows survival rates comparable to those of radiochemotherapy and a higher larynx-preservation rate, although it may not replace radiochemotherapy because it can be recommended only in selected cases. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.

Published
2012

43. The role of radiotherapy in adult medulloblastoma: long-term single-institution experience and a review of the literature

Author

Balducci, Mario, Chiesa, Silvia, Chieffo, Daniela Pia Rosaria, Manfrida, Stefania, Dinapoli, Nicola, Fiorentino, Alice, Miccichè, F, Frascino, Vincenzo, Anile, Carmelo, Valentini, Vincenzo, De Bari, B, Balducci, M (ORCID:0000-0003-0398-9726), Chiesa, S (ORCID:0000-0003-0168-3459), Chieffo, D, Manfrida, S, Dinapoli, N, Fiorentino, A, Frascino, V, Anile, C (ORCID:0000-0002-0481-9713), Valentini, V (ORCID:0000-0003-4637-6487), Balducci, Mario, Chiesa, Silvia, Chieffo, Daniela Pia Rosaria, Manfrida, Stefania, Dinapoli, Nicola, Fiorentino, Alice, Miccichè, F, Frascino, Vincenzo, Anile, Carmelo, Valentini, Vincenzo, De Bari, B, Balducci, M (ORCID:0000-0003-0398-9726), Chiesa, S (ORCID:0000-0003-0168-3459), Chieffo, D, Manfrida, S, Dinapoli, N, Fiorentino, A, Frascino, V, Anile, C (ORCID:0000-0002-0481-9713), and Valentini, V (ORCID:0000-0003-4637-6487)

Abstract

Medulloblastoma (MB) occurs infrequently in adult patients and standard treatment is still controversial. We report our long-term, single-institution experience of adult MB and a review of the literature. We analysed adult patients with histologically proved MB treated by postoperative radiotherapy. Primary endpoints were local control (LC), disease-free survival (DFS), and overall survival (OS). Acute toxicity was reported according to CTC-NCI score vers. 3.0 and specific neuropsychological assessment analysis was performed to define late brain toxicity. From 1990-2008, 13 patients were treated by craniospinal (CSI, 12/13) or cranial irradiation (1/13, because of bad clinical conditions). Median follow up was 101 months (64-218). Complete radiological response was observed in 12/13 patients and a partial response in 1/13. Ten-year LC, OS, and DFS were 91, 76, and 84%, respectively. Two patients died because of local and spinal progression after 13 and 62 months. Acute G3 haematological toxicity (RTOG score) was observed for one patient only. The neuropsychological analysis did not reveal late toxicity related to brain radiotherapy. This experience confirms the efficacy and safety of radiotherapy in adult MB patients, resulting in very interesting 10-year LC and OS.

Published
2012

44. Recurrence in region of spared parotid gland in patient receiving definitive intensity-modulated radiotherapy for nasopharyngeal cancer: A case report

Author

Autorino, Rosa, Mattiucci, Gian Carlo, Dinapoli, Nicola, Bussu, Francesco, Mattiucci, Gc, Galli, Jacopo, Tartaglione, Tommaso, Rufini, Vittoria, Almadori, Giovanni, Paludetti, Gaetano, Valentini, Viola, Balducci, Marinella, Miccichè, F (ORCID:0000-0001-6500-0413), Bussu, Francesco (ORCID:0000-0001-6261-2772), Galli, Jacopo (ORCID:0000-0001-6353-6249), Tartaglione, Tommaso (ORCID:0000-0003-3896-4078), Rufini, Vittoria (ORCID:0000-0002-2052-8078), Almadori, Giovanni (ORCID:0000-0002-4605-2442), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Autorino, Rosa, Mattiucci, Gian Carlo, Dinapoli, Nicola, Bussu, Francesco, Mattiucci, Gc, Galli, Jacopo, Tartaglione, Tommaso, Rufini, Vittoria, Almadori, Giovanni, Paludetti, Gaetano, Valentini, Viola, Balducci, Marinella, Miccichè, F (ORCID:0000-0001-6500-0413), Bussu, Francesco (ORCID:0000-0001-6261-2772), Galli, Jacopo (ORCID:0000-0001-6353-6249), Tartaglione, Tommaso (ORCID:0000-0003-3896-4078), Rufini, Vittoria (ORCID:0000-0002-2052-8078), Almadori, Giovanni (ORCID:0000-0002-4605-2442), and Paludetti, Gaetano (ORCID:0000-0003-2480-1243)

Abstract

Recurrence in region of spared parotid gland in patient receiving definitive intensity-modulated radiotherapy for nasopharyngeal cancer

Published
2012

47. HPV infection in squamous cell carcinomas arising from different mucosal sites of the head and neck region. Is p16 immunohistochemistry a reliable surrogate marker?

Author

Bussu, F, primary, Sali, M, additional, Gallus, R, additional, Vellone, V G, additional, Zannoni, G F, additional, Autorino, R, additional, Dinapoli, N, additional, Santangelo, R, additional, Martucci, R, additional, Graziani, C, additional, Miccichè, F, additional, Almadori, G, additional, Galli, J, additional, Delogu, G, additional, Sanguinetti, M, additional, Rindi, G, additional, Valentini, V, additional, and Paludetti, G, additional

Published
2013
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