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1. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Author

Martinello, Marianne, Matthews, Gail, Fernando, Fay Fabián, Esteban, Juan I., Müllhaupt, Beat, Wiesch, Julian Schulze zur, Buggisch, Peter, Neumann-Haefelin, Christoph, Berg, Thomas, Berg, Christoph P., Schattenberg, Jörn M., Moreno, Christophe, Stauber, Rudolf, Lloyd, Andrew, Dore, Gregory, Applegate, Tanya, Ignacio, Juan, Garcia-Cehic, Damir, Gregori, Josep, Rodriguez-Frias, Francisco, Rando, Ariadna, Gozlan, Yael, Angelico, Mario, Andreoni, Massimo, Babudieri, Sergio, Bertoli, Ada, Cento, Valeria, Coppola, Nicola, Craxì, Antonio, Paolucci, Stefania, Parruti, Giustino, Pasquazzi, Caterina, Perno, Carlo Federico, Teti, Elisabetta, Vironet, C., Lannergård, Anders, Duberg, Ann-Sofi, Aleman, Soo, Gutteberg, Tore, Soulier, Alexandre, Gourgeon, Aurélie, Chevaliez, Stephane, Pol, Stanislas, Carrat, Fabrice, Salmon, Dominique, Kaiser, Rolf, Knopes, Elena, Gomes, Perpetua, de Kneght, Rob, Rijnders, Bart, Poljak, Mario, Lunar, Maja, Usubillaga, Rafael, Seguin_Devaux, Carole, Tay, Enoch, Wilson, Caroline, Wang, Dao Sen, George, Jacob, Kok, Jen, Pérez, Ana Belén, Chueca, Natalia, García-Deltoro, Miguel, Martínez-Sapiña, Ana María, Lara-Pérez, María Magdalena, García-Bujalance, Silvia, Aldámiz-Echevarría, Teresa, Vera-Méndez, Francisco Jesús, Pineda, Juan Antonio, Casado, Marta, Pascasio, Juan Manuel, Salmerón, Javier, Alados-Arboledas, Juan Carlos, Poyato, Antonio, Téllez, Francisco, Rivero-Juárez, Antonio, Merino, Dolores, Vivancos-Gallego, María Jesús, Rosales-Zábal, José Miguel, Ocete, María Dolores, Simón, Miguel Ángel, Rincón, Pilar, Reus, Sergi, De la Iglesia, Alberto, García-Arata, Isabel, Jiménez, Miguel, Jiménez, Fernando, Hernández-Quero, José, Galera, Carlos, Balghata, Mohamed Omar, Primo, Joaquín, Masiá, Mar, Espinosa, Nuria, Delgado, Marcial, von-Wichmann, Miguel Ángel, Collado, Antonio, Santos, Jesús, Mínguez, Carlos, Díaz-Flores, Felícitas, Fernández, Elisa, Bernal, Enrique, De Juan, José, Antón, José Joaquín, Vélez, Mónica, Aguilera, Antonio, Navarro, Daniel, Arenas, Juan Ignacio, Fernández, Clotilde, Espinosa, María Dolores, Ríos, María José, Alonso, Roberto, Hidalgo, Carmen, Hernández, Rosario, Téllez, María Jesús, Rodríguez, Francisco Javier, Antequera, Pedro, Delgado, Cristina, Martín, Patricia, Crespo, Javier, Becerril, Berta, Pérez, Oscar, García-Herola, Antonio, Montero, José, Freyre, Carolina, Grau, Concepción, Cabezas, Joaquin, Jimenez, Miguel, Rodriguez, Manuel Alberto Macias, Quilez, Cristina, Pardo, Maria Rodriguez, Muñoz-Medina, Leopoldo, Figueruela, Blanca, Howe, Anita Y.M., Rodrigo, Chaturaka, Cunningham, Evan B., Douglas, Mark W., Dietz, Julia, Grebely, Jason, Popping, Stephanie, Sfalcin, Javier Alejandro, Parczewski, Milosz, Sarrazin, Christoph, de Salazar, Adolfo, Fuentes, Ana, Sayan, Murat, Quer, Josep, Kjellin, Midori, Kileng, Hege, Mor, Orna, Lennerstrand, Johan, Fourati, Slim, Di Maio, Velia Chiara, Chulanov, Vladimir, Pawlotsky, Jean-Michel, Harrigan, P. Richard, Ceccherini-Silberstein, Francesca, and Garcia, Federico

Published
2022
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3. El alfar vacceo de Tordehumos (Valladolid). Primeros resultados de las prospecciones y excavaciones arqueológicas desarrolladas

Author

Sanz Mínguez, Carlos, Justo Álvarez, Rubén, Muñoz Martín, Alfonso, Coria Noguera, Jose Carlos, de la Peña Fernández-Cañadas, Inés, Rodríguez Gutiérrez, Elvira, Sanz Mínguez, Carlos, Justo Álvarez, Rubén, Muñoz Martín, Alfonso, Coria Noguera, Jose Carlos, de la Peña Fernández-Cañadas, Inés, and Rodríguez Gutiérrez, Elvira

Abstract

This paper presents the initial results of the latest research of the vaccean pottery workshop of Tordehumos (Valladolid). The investigation of the site used diverse documentation techniques. Firstly, a electromagnetic prospection were conducted, through which we obtained a series of tomographic maps showing the resistivity of the ground elements at different depths. Secondly, an archaeological excavation was carried out, in which various materials were found (ceramics, some of them with cooking failures, vitrified revokes of pottery kilns, mud lumps with fingering, etc.) that confirmed the pottery activity in the settlement. In addition, we documented a pit, whose discussion presents different possibilities in relation to its functionality. In spite of the absence of in situ structural elements in this pit, the presence in its bottom of a clay level with charcoal and another with ashes suggest the development of activities related to fire. The results obtained permit to securely associate Tordehumos with the pottery activity during the Second Iron Age of the Northem Plateau, adding another site to the few and poorly known vaccean pottery workshops., En este trabajo se presentan los resultados de las últimas investigaciones llevadas a cabo en el alfar vacceo de Tordehumos (Valladolid). El estudio del sitio ha sido realizado utilizando diversas técnicas de documentación. En primer lugar, se efectuó una prospección electromagnética, a través de la cual obtuvimos una serie de mapas tomográficos en los que se muestra la resistividad de los elementos del terreno a distintas profundidades. En segundo lugar, desarrollamos una campaña de excavación arqueológica, en la que se hallaron diversos materiales (cerámicas, algunas de ellas pasadas de cocción, revocos de paredes vitrificadas, masas de barro con digitaciones, etc.) que confirmaron la actividad alfarera en el asentamiento. Igualmente se pudo identificar una hoya, cuya discusión presenta distintas posibilidades en relación con su funcionalidad. En este sentido, aunque no se pudieron documentar elementos estructurales in situ a ella vinculados, la presencia en su fondo de una capa de arcilla con carbones y un potente paquete de cenizas remiten a actividades pirotecnológicas. Los resultados obtenidos nos permiten asociar Tordehumos con seguridad a como un centro de producción cerámica durante la segunda Edad del Hierro meseteño, sumando así un punto más a los pocos y mal conocidos alfares vacceos., Depto. de Geodinámica, Estratigrafía y Paleontología, Fac. de Ciencias Geológicas, TRUE, pub

Published
2024

5. High efficacy of resistance-guided retreatment of HCV patients failing NS5A inhibitors in the real world

Author

Ocete, María Dolores, Simón, Miguel Ángel, Rincón, Pilar, Reus, Sergi, De la Iglesia, Alberto, García-Arata, Isabel, Jiménez, Miguel, Jiménez, Fernando, Hernández-Quero, José, Galera, Carlos, Balghata, Mohamed Omar, Primo, Joaquín, Masiá, Mar, Espinosa, Nuria, Delgado, Marcial, von-Wichmann, Miguel Ángel, Collado, Antonio, Santos, Jesús, Mínguez, Carlos, Díaz-Flores, Felícitas, Fernández, Elisa, Bernal, Enrique, De Juan, José, Antón, José Joaquín, Vélez, Mónica, Aguilera, Antonio, Navarro, Daniel, Arenas, Juan Ignacio, Fernández, Clotilde, Espinosa, María Dolores, Ríos, María José, Alonso, Roberto, Hidalgo, Carmen, Hernández, Rosario, Téllez, María Jesús, Rodríguez, Francisco Javier, Antequera, Pedro, Delgado, Cristina, Martín, Patricia, Crespo, Javier, Becerril, Berta, Pérez, Óscar, García-Herola, Antonio, Montero, José, Freyre, Carolina, Grau, Concepción, Pérez, Ana Belén, Chueca, Natalia, García-Deltoro, Miguel, Martínez-Sapiña, Ana María, Lara-Pérez, María Magdalena, García-Bujalance, Silvia, Aldámiz-Echevarría, Teresa, Vera-Méndez, Francisco Jesús, Pineda, Juan Antonio, Casado, Marta, Pascasio, Juan Manuel, Salmerón, Javier, Alados-Arboledas, Juan Carlos, Poyato, Antonio, Téllez, Francisco, Rivero-Juárez, Antonio, Merino, Dolores, Vivancos-Gallego, María Jesús, Rosales-Zábal, José Miguel, and García, Federico

Published
2019
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6. Presente y futuro del aprovechamiento del agua regenerada en España. Su implicación en la disponibilidad de recursos para la producción de hidrógeno electrolítico.

Author

Mínguez, Carlos

Abstract

Copyright of Papeles de Energía is the property of Fundacion de los Bancos y Cajas de CECA (FUNCAS) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

7. Evaluation of Non-Contact Device to Measure Body Temperature in Sheep.

Author

Ibáñez, Carla, Moreno-Manrique, María, Villagrá, Aránzazu, Bueso-Ródenas, Joel, and Mínguez, Carlos

Subjects
THERMOGRAPHY, BODY temperature, INFRARED cameras, INFRARED thermometers, INFRARED equipment, MEDICAL thermometry
Abstract

Simple Summary: Rectal thermometry is still standard practice in the measurement of body temperature in livestock because of its low cost. However, there are situations where this method is contraindicated or impractical, and a less invasive method is required. Non-contact devices have been used in livestock production; however, there are few studies about the variation and correlations in body temperature between rectal temperature and non-contact devices. The present work aims to compare rectal temperature with two types of non-contact devices (non-contact infrared thermometers and thermal imaging/infrared thermography) for the assessment of body temperature in healthy sheep. Except for the temperature taken by non-contact infrared thermometers at the muzzle, the correlation between rectal temperature vs. non-contact infrared thermometers or thermal imaging/infrared thermography showed a low significance or was difficult to use for practical flock management purposes. In addition, the variability between devices was high, which implies that measurements should be interpreted with caution in warm climates and open pens, such as most sheep farms in the Spanish Mediterranean area. Non-contact devices have been used in the measurement of body temperature in livestock production as a tool for testing disease in different species. However, there are few studies about the variation and correlations in body temperature between rectal temperature (RT) and non-contact devices such as non-contact infrared thermometers (NCIT) and thermal imaging/infrared thermography (IRT). The objective of this work was to evaluate the accuracy of non-contact devices to measure the body temperature in sheep, considering six body regions and the possibility of implementing these systems in herd management. The experiment was carried out at the experimental farm of the Catholic University of Valencia, located in the municipality of Massanassa in July of 2021, with 72 dry manchega ewes, and we compared the rectal temperature with two types of non-contact infrared devices for the assessment of body temperature in healthy sheep. Except for the temperature taken by NCIT at the muzzle, the correlation between RT vs. NCIT or IRT showed a low significance or was difficult to use for practical flock management purposes. In addition, the variability between devices was high, which implies that measurements should be interpreted with caution in warm climates and open pens, such as most sheep farms in the Spanish Mediterranean area. The use of infrared cameras devices to assess body temperature may have a promising future, but in order to be widely applied as a routine management method on farms, the system needs to become cheaper, simpler in terms of measurements and quicker in terms of analyzing results. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Impact of HIV on the survival of hepatocellular carcinoma in hepatitis C virus-infected patients

Author

Merchante, Nicolás, Rodríguez-Fernández, Miguel, Figueruela, Blanca, Rodríguez-Arrondo, Francisco, Revollo, Boris, Ibarra, Sofía, Téllez, Francisco, Merino, Esperanza, Montero-Alonso, Marta, Galindo, María J., Rivero-Juárez, Antonio, Santos, Ignacio de Los, Delgado-Fernández, Marcial, García-Deltoro, Miguel, Vera-Méndez, Francisco J., García, María A., Aguirrebengoa, Koldo, Portu, Joseba, Ríos-Villegas, María J., Villalobos, Marina, Alemán-Valls, María R., Mínguez, Carlos, Galera, Carlos, Macías, Juan, and Pineda, Juan A.

Published
2020
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13. Increasing Incidence of Hepatocellular Carcinoma in HIV-Infected Patients in Spain

Author

Merchante, Nicolás, Merino, Esperanza, López-Aldeguer, José, Jover, Francisco, Delgado-Fernández, Marcial, Galindo, Maria José, Ortega, Enrique, Rivero, Antonio, Mínguez, Carlos, Romero-Palacios, Alberto, Padilla, Sergio, Márquez-Solero, Manuel, Amador, Concepción, Ríos-Villegas, Maria José, Téllez, Francisco, Portilla, Joaquín, and Pineda, Juan A.

Published
2013
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16. Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Author

Howe, Anita Y.M., primary, Rodrigo, Chaturaka, additional, Cunningham, Evan B., additional, Douglas, Mark W., additional, Dietz, Julia, additional, Grebely, Jason, additional, Popping, Stephanie, additional, Sfalcin, Javier Alejandro, additional, Parczewski, Milosz, additional, Sarrazin, Christoph, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Sayan, Murat, additional, Quer, Josep, additional, Kjellin, Midori, additional, Kileng, Hege, additional, Mor, Orna, additional, Lennerstrand, Johan, additional, Fourati, Slim, additional, Di Maio, Velia Chiara, additional, Chulanov, Vladimir, additional, Pawlotsky, Jean-Michel, additional, Harrigan, P. Richard, additional, Ceccherini-Silberstein, Francesca, additional, Garcia, Federico, additional, Martinello, Marianne, additional, Matthews, Gail, additional, Fernando, Fay Fabián, additional, Esteban, Juan I., additional, Müllhaupt, Beat, additional, Wiesch, Julian Schulze zur, additional, Buggisch, Peter, additional, Neumann-Haefelin, Christoph, additional, Berg, Thomas, additional, Berg, Christoph P., additional, Schattenberg, Jörn M., additional, Moreno, Christophe, additional, Stauber, Rudolf, additional, Lloyd, Andrew, additional, Dore, Gregory, additional, Applegate, Tanya, additional, Ignacio, Juan, additional, Garcia-Cehic, Damir, additional, Gregori, Josep, additional, Rodriguez-Frias, Francisco, additional, Rando, Ariadna, additional, Gozlan, Yael, additional, Angelico, Mario, additional, Andreoni, Massimo, additional, Babudieri, Sergio, additional, Bertoli, Ada, additional, Cento, Valeria, additional, Coppola, Nicola, additional, Craxì, Antonio, additional, Paolucci, Stefania, additional, Parruti, Giustino, additional, Pasquazzi, Caterina, additional, Perno, Carlo Federico, additional, Teti, Elisabetta, additional, Vironet, C., additional, Lannergård, Anders, additional, Duberg, Ann-Sofi, additional, Aleman, Soo, additional, Gutteberg, Tore, additional, Soulier, Alexandre, additional, Gourgeon, Aurélie, additional, Chevaliez, Stephane, additional, Pol, Stanislas, additional, Carrat, Fabrice, additional, Salmon, Dominique, additional, Kaiser, Rolf, additional, Knopes, Elena, additional, Gomes, Perpetua, additional, de Kneght, Rob, additional, Rijnders, Bart, additional, Poljak, Mario, additional, Lunar, Maja, additional, Usubillaga, Rafael, additional, Seguin_Devaux, Carole, additional, Tay, Enoch, additional, Wilson, Caroline, additional, Wang, Dao Sen, additional, George, Jacob, additional, Kok, Jen, additional, Pérez, Ana Belén, additional, Chueca, Natalia, additional, García-Deltoro, Miguel, additional, Martínez-Sapiña, Ana María, additional, Lara-Pérez, María Magdalena, additional, García-Bujalance, Silvia, additional, Aldámiz-Echevarría, Teresa, additional, Vera-Méndez, Francisco Jesús, additional, Pineda, Juan Antonio, additional, Casado, Marta, additional, Pascasio, Juan Manuel, additional, Salmerón, Javier, additional, Alados-Arboledas, Juan Carlos, additional, Poyato, Antonio, additional, Téllez, Francisco, additional, Rivero-Juárez, Antonio, additional, Merino, Dolores, additional, Vivancos-Gallego, María Jesús, additional, Rosales-Zábal, José Miguel, additional, Ocete, María Dolores, additional, Simón, Miguel Ángel, additional, Rincón, Pilar, additional, Reus, Sergi, additional, De la Iglesia, Alberto, additional, García-Arata, Isabel, additional, Jiménez, Miguel, additional, Jiménez, Fernando, additional, Hernández-Quero, José, additional, Galera, Carlos, additional, Balghata, Mohamed Omar, additional, Primo, Joaquín, additional, Masiá, Mar, additional, Espinosa, Nuria, additional, Delgado, Marcial, additional, von-Wichmann, Miguel Ángel, additional, Collado, Antonio, additional, Santos, Jesús, additional, Mínguez, Carlos, additional, Díaz-Flores, Felícitas, additional, Fernández, Elisa, additional, Bernal, Enrique, additional, De Juan, José, additional, Antón, José Joaquín, additional, Vélez, Mónica, additional, Aguilera, Antonio, additional, Navarro, Daniel, additional, Arenas, Juan Ignacio, additional, Fernández, Clotilde, additional, Espinosa, María Dolores, additional, Ríos, María José, additional, Alonso, Roberto, additional, Hidalgo, Carmen, additional, Hernández, Rosario, additional, Téllez, María Jesús, additional, Rodríguez, Francisco Javier, additional, Antequera, Pedro, additional, Delgado, Cristina, additional, Martín, Patricia, additional, Crespo, Javier, additional, Becerril, Berta, additional, Pérez, Oscar, additional, García-Herola, Antonio, additional, Montero, José, additional, Freyre, Carolina, additional, Grau, Concepción, additional, Cabezas, Joaquin, additional, Jimenez, Miguel, additional, Rodriguez, Manuel Alberto Macias, additional, Quilez, Cristina, additional, Pardo, Maria Rodriguez, additional, Muñoz-Medina, Leopoldo, additional, and Figueruela, Blanca, additional

Published
2022
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24. Actividad antifúngica y antitoxigénica in vitro y en alimentos de bacterias ácido lácticas

Author

Luz Mínguez, Carlos, Mañes Vinuesa, Jordi, Meca, Giuseppe, and Departament de Medicina Preventiva i Salut Pública, Ciències de l'Alimentació, Toxicologia i Medicina Legal

Subjects
suero de leche, hongos toxigénicos, bioconservación, CIENCIAS AGRARIAS::Producción animal [UNESCO], UNESCO::CIENCIAS MÉDICAS, bacterias ácido lácticas, actividad antifúngica, UNESCO::CIENCIAS AGRARIAS::Producción animal, CIENCIAS MÉDICAS [UNESCO]
Abstract

El desarrollo de hongos en materias primas, alimentos y piensos puede ser responsable de pérdidas económicas considerables por disminuir la calidad y reducir la vida media de todos ellos. Además, algunos hongos pueden producir compuestos potencialmente tóxicos, lo que supone un problema de seguridad alimentaria para los consumidores. La bioconservación es un concepto que se refiere al empleo de microorganismos o sus productos metabólicos en los alimentos, para inhibir el crecimiento o destruir microorganismos no deseados, con el objetivo de mejorar la seguridad, conservar la calidad y extender la vida útil de los productos alimenticios. La presente Tesis Doctoral tiene por objeto el estudio de la actividad antifúngica de bacterias ácido lácticas (BAL) frente a hongos productores de micotoxinas pertenecientes a los géneros Aspergillus, Penicillium y Fusarium. Para tal efecto, se realizaron fermentaciones en caldo MRS, suero de leche y masa madre panaria, y se determinaron los valores de concentración mínima fungicida, a efectos de comparar el potencial antifúngico. En base a estos primeros datos, se planteó la necesidad de desarrollar estrategias basadas en el uso de las BAL más activas como cultivos iniciadores de fermentación en el propio alimento o bien empleando el caldo fermentado libre o no de células como ingrediente, de manera que proporcionaran valores positivos en cuanto a el aumentar la vida útil de los alimentos y la reducción de la presencia de micotoxinas. Los resultados obtenidos reflejan una eficacia de las BAL y los medios fermentados como conservantes de origen natural frente a P. expansum en pan, con valores medios equivalentes o ligeramente superiores a los que presentan los conservantes clásicos ampliamente utilizados por la industria alimentaria, como es el caso del propianato de calcio. Por otra parte, la pulverización del caldo MRS fermentado por L. plantarum CECT 749 retrasó el crecimiento de A. flavus en maíz y F. verticillioides en mazorca en varios días frente al blanco. Dicho tratamiento evidenció una muy importante reducción en la producción de AFB1 por A. flavus en maíz, y por F. verticillioides en mazorcas de maíz durante el almacenamiento. Como efectos beneficiosos adicionales, cabe decir que la digestión gastrointestinal de pan contaminado con OTA y previamente tratado con diversos inóculos de BAL mostraron una marcada reducción de la bioaccesibilidad de la micotoxina en los diferentes compartimentos digestivos in vitro. Y que la fermentación del suero de leche con cepas de L. plantarum mostraron un aumento de la capacidad antioxidante, un mayor porcentaje de la actividad inhibitoria de la enzima convertidora de la angiotensina y un incremento de la capacidad de quelación del hierro. The development of fungi in raw materials, food and feed can be responsible for considerable economic losses by decreasing quality and reducing the shelf life of all of them. In addition, some fungi can produce potentially toxic compounds, posing a food safety problem for consumers. Biopreservation is a concept that refers to the use of microorganisms or their metabolic products in food, to inhibit the growth or destroy unwanted microorganisms, with the aim of improving safety, preserving quality and extending the shelf life of food products. The purpose of this Doctoral Thesis is to study the antifungal activity of lactic acid bacteria (LAB) against fungi that produce mycotoxins belonging to the genera Aspergillus, Penicillium and Fusarium. For this purpose, fermentations were carried out in MRS broth, whey and panary sourdough, and the minimum fungicidal concentration values were determined, in order to compare the antifungal potential. Based on these first data, the need to develop strategies based on the use of the most active LAB as fermentation starter cultures in the food itself or using the cell-free or non-cell-free fermented broth as an ingredient was raised, in order to provide positive values in terms of increasing the shelf life of food and reducing the presence of mycotoxins. The results obtained reflect the efficacy of LAB and the fermented media as preservatives of natural origin against P. expansum in bread, with mean values equivalent to or slightly higher than those of the classic preservatives widely used by the food industry, such as case of calcium propionate. On the other hand, the spraying of the MRS broth fermented by L. plantarum CECT 749 delayed the growth of A. flavus in corn and F. verticillioides on the cob for several days against white. This treatment evidenced a very important reduction in the production of AFB1 by A. flavus in corn, and by F. verticillioides in corn cobs during storage. As additional beneficial effects, it can be said that the gastrointestinal digestion of bread contaminated with OTA and previously treated with various LAB inoculum showed a marked reduction in the bioavailability of mycotoxin in the different digestive compartments in vitro. And that the fermentation of the whey with L. plantarum strains showed an increase in the antioxidant capacity, a higher percentage of the inhibitory activity of the angiotensin-converting enzyme and an increase in the chelation capacity of iron.

Published
2020

30. Montealegre de Campos (Valladolid) : una ciudad vacceo-romana en el páramo de Torozos

Author

Prieto de la Rosa, Álvaro, Sanz Mínguez, Carlos, Universidad de Valladolid. Facultad de Filosofía y Letras, Prieto de la Rosa, Álvaro, Sanz Mínguez, Carlos, and Universidad de Valladolid. Facultad de Filosofía y Letras

Abstract

El yacimiento vacceo-romano de Montealegre de Campos, ubicado en el límite de la región de Torozos, es un ejemplo de ciudad vaccea y de urbanismo prerromano. Su estudio ha estado condicionado por dos acontecimientos: el hallazgo de la Tessera Hospitalis, en 1985, y las excavaciones de Manuel Retuerce entre 2008 y 2010. Estos dos hitos, nos hablan de las relaciones a partir de la ocupación romana, entre éstos y los indígenas, así como de la evolución en la ocupación del espacio desarrollada por el pueblo vacceo. Este enclave, a pesar de haber sido declarado BIC en 1980, se halla en una situación patrimonial muy precaria, reflejo del momento en que vivimos para la protección de nuestro patrimonio., Departamento de Prehistoria, Arqueología, Antropología Social y Ciencias y Técnicas Historiográficas, Grado en Historia

Published
2019

31. Low performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma in HIV-infected patients

Author

Junta de Andalucía, European Commission, Instituto de Salud Carlos III, Merchante, Nicolás, Figueruela, Blanca, Rodríguez-Fernández, Miguel, Rodríguez-Arrondo, Francisco, Revollo, Boris, Ibarra, Sofía, Galindo, María José, Merino, Esperanza, Montero, Marta, Téllez, Francisco, García-Deltoro, Miguel, Rivero-Juárez, Antonio, Delgado-Fernández, Marcial, Ríos-Villegas, María José, Aguirrebengoa, Koldo, García, María A., Portu, Joseba, Vera-Méndez, Francisco Jesús, Villalobos, Marina, Mínguez, Carlos, De Los Santos, Ignacio, López-Ruz, Miguel A., Omar, Mohamed, Galera-Peñaranda, Carlos, Macías Sánchez, Juan, Pineda, Juan A., Junta de Andalucía, European Commission, Instituto de Salud Carlos III, Merchante, Nicolás, Figueruela, Blanca, Rodríguez-Fernández, Miguel, Rodríguez-Arrondo, Francisco, Revollo, Boris, Ibarra, Sofía, Galindo, María José, Merino, Esperanza, Montero, Marta, Téllez, Francisco, García-Deltoro, Miguel, Rivero-Juárez, Antonio, Delgado-Fernández, Marcial, Ríos-Villegas, María José, Aguirrebengoa, Koldo, García, María A., Portu, Joseba, Vera-Méndez, Francisco Jesús, Villalobos, Marina, Mínguez, Carlos, De Los Santos, Ignacio, López-Ruz, Miguel A., Omar, Mohamed, Galera-Peñaranda, Carlos, Macías Sánchez, Juan, and Pineda, Juan A.

Abstract

[Objective]: To assess the performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma (HCC) in HIV-infected patients., [Methods]: The GEHEP-002 cohort recruits HCC cases diagnosed in HIV-infected patients from 32 centers across Spain. The proportion of ‘ultrasound lack of detection’, defined as HCC diagnosed within the first 3 months after a normal surveillance ultrasound, and the proportion of ‘surveillance failure’, defined as cases in which surveillance failed to detect HCC at early stage, were assessed. To assess the impact of HIV, a control population of 104 HCC cases diagnosed in hepatitis C virus-monoinfected patients during the study period was used., [Results]: A total of 186 (54%) out of 346 HCC cases in HIV-infected patients were diagnosed within an ultrasound surveillance program. Ultrasound lack of detection occurred in 16 (8.6%) of them. Ultrasound surveillance failure occurred in 107 (57%) out of 186 cases diagnosed by screening, whereas this occurred in 18 (29%) out of 62 diagnosed in the control group (P < 0.0001). HCC cases after ultrasound surveillance failure showed a lower frequency of undetectable HIV viral load at diagnosis. The probability of 1-year and 2-year survival after HCC diagnosis among those diagnosed by screening was 56 and 45% in HIV-infected patients, whereas it was 79 and 64% in HIV-negative patients (P = 0.038)., [Conclusion]: The performance of ultrasound surveillance of HCC in HIV-infected patients is very poor and worse than that shown outside HIV infection. A HCC surveillance policy based on ultrasound examinations every 6 months might be insufficient in HIV-infected patients with cirrhosis.

Published
2019

32. Genetic analysis of functional longevity in a complete diallel crossing experiment involving four maternal rabbit lines.

Author

Ragab, Mohamed, Baselga, Manuel, EL Nagar, Ayman G., Mínguez, Carlos, and Pablo Sánchez, Juan

Subjects
HETEROSIS, CROSSBREEDING, FIXED effects model, PROPORTIONAL hazards models, FUNCTIONAL analysis, LONGEVITY, RABBIT meat
Abstract

In a diallel cross between four maternal lines of rabbits, the four maternal lines and the corresponding crossbred females (does) were evaluated concerning functional longevity, estimating their crossbreeding components. Sixteen genetic groups were produced by using four maternal lines of rabbit (A, V, H and LP (L)). The groups were distributed over 4 Spanish farms. In all farms, the V line was present as the reference group. A total of 7,211 does' longevity records were recorded. Using a Cox proportional hazard model of fixed effects, survival analysis was performed to study longevity analysing the hazard of death or culling. Does from lines A, H and V had similar risks of death or of being culled, and they were more susceptible compared with those from line L. The lowest hazard was associated with L line does. No significant differences were found between the average of all crosses and the V line except when comparing the V line to the cross between A and H lines, favouring the former (1.30 higher risk of replacement for AH animals). Significant differences between reciprocal crosses were observed between VH and HV, in favour of HV (0.72 of relative risk of replacement) and between LH and HL, in favour of HL (0.76 of relative risk). Line V had the highest risk due to the direct genetic effects, and these differences were significant with the lines H (1.40 of relative risk) and L (1.43 of relative risk). The differences in maternal genetic effects were small and not significant except between lines H and V in favour of V line (0.75 of relative risk). The estimated direct heterosis effects do not always follow the same trend but they showed the importance of the crossing between specialized lines to produce crossbred does for intensive meat rabbit production. [ABSTRACT FROM AUTHOR]

Published
2021
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33. High efficacy of resistance-guided retreatment of HCV patients failing NS5A inhibitors in the real world

Author

Pérez, Ana Belén, primary, Chueca, Natalia, additional, García-Deltoro, Miguel, additional, Martínez-Sapiña, Ana María, additional, Lara-Pérez, María Magdalena, additional, García-Bujalance, Silvia, additional, Aldámiz-Echevarría, Teresa, additional, Vera-Méndez, Francisco Jesús, additional, Pineda, Juan Antonio, additional, Casado, Marta, additional, Pascasio, Juan Manuel, additional, Salmerón, Javier, additional, Alados-Arboledas, Juan Carlos, additional, Poyato, Antonio, additional, Téllez, Francisco, additional, Rivero-Juárez, Antonio, additional, Merino, Dolores, additional, Vivancos-Gallego, María Jesús, additional, Rosales-Zábal, José Miguel, additional, García, Federico, additional, Ocete, María Dolores, additional, Simón, Miguel Ángel, additional, Rincón, Pilar, additional, Reus, Sergi, additional, De la Iglesia, Alberto, additional, García-Arata, Isabel, additional, Jiménez, Miguel, additional, Jiménez, Fernando, additional, Hernández-Quero, José, additional, Galera, Carlos, additional, Balghata, Mohamed Omar, additional, Primo, Joaquín, additional, Masiá, Mar, additional, Espinosa, Nuria, additional, Delgado, Marcial, additional, von-Wichmann, Miguel Ángel, additional, Collado, Antonio, additional, Santos, Jesús, additional, Mínguez, Carlos, additional, Díaz-Flores, Felícitas, additional, Fernández, Elisa, additional, Bernal, Enrique, additional, De Juan, José, additional, Antón, José Joaquín, additional, Vélez, Mónica, additional, Aguilera, Antonio, additional, Navarro, Daniel, additional, Arenas, Juan Ignacio, additional, Fernández, Clotilde, additional, Espinosa, María Dolores, additional, Ríos, María José, additional, Alonso, Roberto, additional, Hidalgo, Carmen, additional, Hernández, Rosario, additional, Téllez, María Jesús, additional, Rodríguez, Francisco Javier, additional, Antequera, Pedro, additional, Delgado, Cristina, additional, Martín, Patricia, additional, Crespo, Javier, additional, Becerril, Berta, additional, Pérez, Óscar, additional, García-Herola, Antonio, additional, Montero, José, additional, Freyre, Carolina, additional, and Grau, Concepción, additional

Published
2019
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35. Low performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma in HIV-infected patients

Author

Merchante, Nicolás, primary, Figueruela, Blanca, additional, Rodríguez-Fernández, Miguel, additional, Rodríguez-Arrondo, Francisco, additional, Revollo, Boris, additional, Ibarra, Sofía, additional, Galindo, María J., additional, Merino, Esperanza, additional, Montero, Marta, additional, Téllez, Francisco, additional, García-Deltoro, Miguel, additional, Rivero-Juárez, Antonio, additional, Delgado-Fernández, Marcial, additional, Ríos-Villegas, María J., additional, Aguirrebengoa, Koldo, additional, García, María A., additional, Portu, Joseba, additional, Vera-Méndez, Francisco J., additional, Villalobos, Marina, additional, Mínguez, Carlos, additional, De Los Santos, Ignacio, additional, López-Ruz, Miguel A., additional, Omar, Mohamed, additional, Galera, Carlos, additional, Macias, Juan, additional, and Pineda, Juan A., additional

Published
2019
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36. Las fíbulas anulares hispánicas del oppidum vacceo-romano de Pintia (Padilla de Duero/Peñafiel, Valladolid)

Author

Rodríguez Gutiérrez, Elvira, Sanz Mínguez, Carlos, Universidad de Valladolid. Facultad de Filosofía y Letras, Rodríguez Gutiérrez, Elvira, Sanz Mínguez, Carlos, and Universidad de Valladolid. Facultad de Filosofía y Letras

Abstract

El conjunto de fíbulas recuperado en la Zona Arqueológica Pintia, situada entre Padilla de Duero (Peñafiel) y Pesquera de Duero (Valladolid), asciende a trescientos treinta y tres ejemplares. De esta nutrida colección hemos centrado nuestro estudio en las anulares hispánicas que suman un total de cincuenta y siete ejemplares. Su estudio nos ha proporcionado información relevante sobre diversos aspectos de los vacceos tales como la jerarquización social, el desarrollo artesanal o el mundo de las creencias. Esta etnia habitó en la cuenca media del Duero, una de las más relevantes del panorama meseteño durante la protohistoria peninsular., The set of brooch recovered in the Pintia Archaeological Zone, located between Padilla de Duero (Peñafiel) and Pesquera de Duero (Valladolid), amounts to three hundred and thirty-three copies. From this large collection we have focused our study on the Hispanic annulars that total a total of fifty- seven copies. Their study has provided us with relevant information on various aspects of vaccei such as social hierarchization, artisanal development or the world of beliefs. This ethnic group inhabited in the middle basin of the Duero one of the most important of the Central plateau panorama during the peninsular protohistory., Departamento de Prehistoria, Arqueología, Antropología Social y Ciencias y Técnicas Historiográficas, Grado en Historia

Published
2018

40. Los sistemas defensivos de las ciudades vacceas

Author

Esteban Amo, Isabel, Sanz Mínguez, Carlos, Universidad de Valladolid. Facultad de Filosofía y Letras, Esteban Amo, Isabel, Sanz Mínguez, Carlos, and Universidad de Valladolid. Facultad de Filosofía y Letras

Abstract

Los sistemas defensivos suponen un elemento principal en las ciudades vacceas en el valle medio del Duero a lo largo de la segunda Edad del Hierro. El objetivo de este trabajo es, partiendo de las fuentes clásicas, la arqueología aérea y las excavaciones realizadas hasta la fecha en ocho emplazamientos vacceos –Pintia, Cauca, Pallantia, La Ciudad de Paredes de Nava, Cuestacastro, Las Quintanas de Valoria, Viminatium y Dessobriga– , construir una idea general acerca de las defensas, tanto naturales como artificiales; y determinar en el caso de éstas últimas su morfología, elementos característicos, partes principales y materiales constructivos. Sin dejar a un lado la importancia simbólica, función emblemática y de cohesión social que las defensas tenían dentro de la comunidad., Defensive systems are an important element in the Vaccei cities in the middle valley of the Douro during the Second Iron Age. Based on the classical sources, the purpose of this paper is to study the aerial archeology and excavations carried out to date in eight Vaccei locations-Pintia, Cauca, Pallantia, La Ciudad de Paredes de Nava, Cuestacastro, Las Quintanas de Valoria, Viminatium and Dessobriga- in order to construct a general idea of g the natural and the artificial defenses; and to determine, in the case of the latter, their morphology, characteristic elements, main parts and construction materials. All this without neglecting the symbolic importance, and social cohesive function that the defenses had within the community., Departamento de Prehistoria, Arqueología, Antropología Social y Ciencias y Técnicas Historiográficas, Grado en Historia

Published
2017

41. Recensiones

Author

Podgorny, Irina, Cacho Quesada, Carmen, Cruz Berrocal, María, Hernández, Mauro, Consuegra Rodríguez, Susana, Lorrio, Alberto J, Sanz Mínguez, Carlos, and Cardete del Olmo, Mª Cruz

Subjects
lcsh:Archaeology, lcsh:CC1-960
Published
2007

43. El legado Vacceo

Author

Sanz Mínguez, Carlos and Universidad de Valladolid. Facultad de Filosofía y Letras

Subjects
Vacceos, Prehistoria, Arquitectura
Abstract

La Universidad de Valladolid, dentro de su proyecto “Saber, Extender” ha creado las denominadas ”píldoras de conocimiento”. Son contenidos multimedia de corta duración cuyo objeto es la formación. El profesor crea contenidos referentes a las asignaturas que imparte., Departamento de Prehistoria, Arqueología, Antropología Social y Ciencias y Técnicas Historiográficas

Published
2013

44. Los sonajeros vacceos

Author

Romero Carnicero, Fernando, Sanz Mínguez, Carlos, Górriz Gañán, Cristina, Pablo Martínez, Roberto de, and Ediciones Universidad de Valladolid

Subjects
Arqueología
Abstract

In this paper thirty Vaccean rattles are being studied. The Vaccean rattles are small closed hollow artifacts made of clay or ceramics, with small lumps of clay inside. These objects, make a noise when they are shaken, like modem rattles, which is why the same name is used to describe them. Normally these rattles are decorated with similar motifs such as animal-shaped boxes, votive feet, or boats, all of which are peculiar to Vaccean production. From the morphological analysis the rattles can be defined into six differ ent groups: spherical, hemispherical, lenticular, cylindrical, reel and spindle-shaped. Their chronology sets a framework that dates back from the 3rd century B.C. to the 1st century A.D., Se reúne aquí una treintena de pequeños objetos de cerámica, cerrados y huecos, que contienen en su interior pequeñas pellas de barro, razón por la que, al ser agitados, producen un tintineo; rasgos todos ellos que, por analogía con los sonajeros actuales, llevan a contemplarlos como tales. Generalmente se decoran con idénticos motivos y técnicas que cajitas, pies votivos o barcas, piezas todas ellas incluidas entre las producciones singulares vacceas; este dato y el hecho de que su distribución geográfica se atenga a la de dicho grupo étnico permiten considerarlos una creación más del mismo. Su estudio morfológico permite definir hasta seis tipos distintos: esférico, hemisférico, lenticular, cilíndrico, de carrete y fusiforme y su cronología remite al espacio temporal que media entre los siglos III a.C. y el I d.C.

Published
2013

45. La familia en el proceso de adaptación de un TGD en menores de 10 años: aproximación desde el Trastorno Autista y el Síndrome de Asperger

Author

Gracia Mínguez, Carlos, Oliete Tirao, María Griselda, Zapata Lafuente, Laura, and Montalvo Ateaga, Esperanza

Subjects
trastorno autista, familia, proceso de adaptación, síndrome de asperger, trastorno generalizado del desarrollo (tgd), atención temprana, menores
Abstract

El objetivo principal del presente trabajo es conocer el proceso de normalización y adaptación del núcleo familiar durante el proceso de diagnóstico de un Trastorno Generalizado del Desarrollo, en concreto el Trastorno Autista y el Síndrome de Asperger. Concretamente se estudian familias cuyos hijos han sido diagnosticados antes de los 10 años, este intervalo de edad incluye el periodo en que se ejecuta el Programa de Atención Temprana, diseñado para intervenir con niños con problemas de desarrollo de 0 a 6 años. El proceso de investigación se basa sustancialmente en la recopilación documental, la realización de entrevistas cualitativas a profesionales y familias afectadas y el análisis y valoración de los resultados obtenidos. La vía de acceso a las familias, para su posterior entrevista, ha sido posible gracias a la colaboración de la Asociación Autismo Aragón y la Asociación Asperger y TGD de Aragón. Finalmente se exponen las conclusiones de la investigación y se plantean una serie de posibles líneas de investigación futuras.

Published
2013

48. VI Simposio sobre Celtíberos: Ritos y mitos

Author

Sanz Mínguez, Carlos and Romero Carnicero, Fernando

Subjects
Mujeres - España - Historia, Vacceos, Necrópolis - España - Valladolid (Provincia), Yacimientos arqueológicos - Padilla de Duero (Valladolid)
Abstract

Producción Científica, Las tumbas aristocráticas detectadas en Pintia vinculadas a mujeres y niñas, ofrecen información de interés en cuanto a ciertos comportamientos y usos que alcanzan por igual a hombres o mujeres, así como en cuanto a la presencia de objetos que podrían ser considerados herencia e incluso dotes de mujeres procedentes de otras etnias.

Published
2010

49. El vino en Pintia: nuevos datos y lecturas

Author

Sanz Mínguez, Carlos, Romero Carnicero, Fernando, and Górriz Gañán, Cristina

Subjects
Vacceos, Yacimientos arqueológicos - Padilla de Duero (Valladolid)
Abstract

Producción Científica R

Published
2010

50. Cerámicas torneadas negras de superficie y decoración bruñida. Breves apuntes para la definición de una nueva producción vaccea

Author

Sanz Mínguez, Carlos, Romero Carnicero, Fernando, Górriz Gañán, Cristina, and Pablo Martínez, Roberto de

Subjects
Vacceos, Necrópolis - España - Valladolid (Provincia), Yacimientos arqueológicos - Padilla de Duero (Valladolid)
Abstract

Producción Científica, Las producciones cerámicas vacceas van más allá de las típicas cerámicas anaranjadas pintadas o de las más comunes o toscas. Este tipo de cerámica negra bruñida se conocía muy escasamente; sin embargo el registro más recientemente obtenido en la necrópolis de Las Ruedas, correspondiente a los siglos II-I a.C., ha rendido una buena muestra de ellas, observando una gran variedad formal.

Published
2010

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