170 results on '"Mićić D"'
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2. Acute leukemia of childhood: A single institution's experience
- Author
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Slavković Bojana, Guć-Šćekić Marija, Bunjevački Gordana, Đuričić S., Krstić Aleksandra, Mićić D., Vujić Dragana, Kuzmanović M., and Rašović-Gvozdenović Nada
- Subjects
acute leukemia ,childhood ,hemopathology ,Serbia and Montenegro ,Biology (General) ,QH301-705.5 - Abstract
The aim of this study was to investigate distribution of immunophenotypic and cytogenetic features of childhood acute leukemia (AL) in the cohort of 239 newly diagnosed patients registered at the leading pediatric oncohematology center in the country during a six-year period (1996-2002). With approximately 60-70% of all childhood AL cases in Serbia and Montenegro being diagnosed and treated in this institution the used data represent a valid research sample to draw conclusions for entire country. On the basis of five phenotypic markers, the distribution of immunological subtypes was as follows: 169 (70.7%) expressed B-cell marker CD19 (137 were CD10 positive and 32 CD10 negative), 37 (15.5%) belonged to T-lineage acute lymphoblastic leukemia (T-ALL) (cyCD3 positive), and 33 (13.8%) were acute myeloblastic leukemia (AML) (CD13 positive and/or CD33 positive in the absence of lymphoid-associated antigens). The ratio of males and females was 1.5:1. Most of the cases were between the ages of 2 and 4, and were predominantly B-lineage acute lymphoblastic leukemia (B-ALL) cases. Another peak of age distribution was observed at the age of 7. The frequency of T-ALL (18% of ALL) was similar to that reported for Mediterranean countries: France (19.4%), Greece (28.1%), Southern Italy (28.3%), and Bulgaria (28.0%). Cytogenetic analyses were performed in 193 patients: 164 ALL and 29 AML. Normal karyotype was found in 57% of ALL and in 55% of AML patients, while cytogenetic abnormalities including structural, numerical, and complex chromosomal rearrangements were found in 43% of ALL and in 45% of AML patients. Our results represent a contribution to epidemiological aspects of childhood leukemia studies.
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- 2005
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3. The World Federation of Hemophilia World Bleeding Disorders Registry: insights from the first 10,000 patients
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Abdel Mohsen, M., Adeyemo, T., Ai Sim, G., Al-Rahal, N., Alexis, C., Ali, T., Awodu, O., Aysarieva, B., Aziz, A., Barsallo, N., Biswas, A., Blair, A., Blatny, J., Borhany, M., Castillo, D., Catarino, C., Chuansumrit, A., Coetzee, M., Darwish Mohamad Ibrahim, A., Diop, S., Djenouni, A., El Ekiaby, A., El Khorassani, M., Fawcett, K., Ganieva, A., Govindan, S., Gwarzo, D., Hailemariam, S., Harper, P., Hassan, T., Hassan, M., Hermans, C., Hernandez, F., Imran, A., John, J., Keikhaei, B., Kotila, T., Liam, C., Marhaeni, W., Mbanya, D., Mekjarusgul, P., Meknassi, N., Micic, D., Mlombe, Y., Motusheva, R., Munube, D., Nagao, A., Najmi, S., Narayana Pillai, V., Narbekov, T., Nasution, D., Natesirinilkul, R., Nchimba, L., N’dogomo, M., Neme, D., Nguyen, P., Nguyen, HM., Nguyen Thi, M., Nigam, RK., Njuguna, F., Nwagha, T., Obeida, A., Owusu-Ofori, S., Palascak, J., Pellegrini, G., Philip, C., Ping, CL., Poudyal, B., Rabbani, G., Rakoto Alson, OA., Razali, H., Ruchutrakul, T., Ruiz-Saez, A., Saengboon, S., Salhi, N., Satti, M., See Guan, T., Shah, S., Shikuku, T., Si Yuan, N., Sidarthan, N., Siew Looi, T., Songthawee, N., Sosothikul, D., Surapolchai, P., Suryani, S., Syakira, NA., Thevarajah, A., Tzong, TJ., Udo, C., Wong, L., Yuguda, S., Zafar, T., Zaman Miah, M., Coffin, Donna, Gouider, Emma, Konkle, Barbara, Hermans, Cedric, Lambert, Catherine, Diop, Saliou, Ayoub, Emily, Tootoonchian, Ellia, Youttananukorn, Toong, Dakik, Pamela, Pereira, Ticiana, Iorio, Alfonso, and Pierce, Glenn F.
- Published
- 2023
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4. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Glasbey, James, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Arnaud, Alexis P, Ayasra, Faris, Azevedo, José, Minaya-Bravo, Ana, Costas-Chavarri, Ainhoa, Edwards, John, Elhadi, Muhammed, Fiore, Marco, Fotopoulou, Christina, Gallo, Gaetano, Ghosh, Dhruva, Griffiths, Ewen A, Harrison, Ewen, Hutchinson, Peter, Lawani, Ismail, Lawday, Samuel, Lederhuber, Hans, Leventoglu, Sezai, Li, Elizabeth, Gomes, Gustavo Mendonça Ataíde, Mann, Harvinder, Marson, Ella J, Martin, Janet, Mazingi, Dennis, McLean, Kenneth, Modolo, Maria, Moore, Rachel, Morton, Dion, Ntirenganya, Faustin, Pata, Francesco, Picciochi, Maria, Pockney, Peter, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April Camilla, Kottayasamy Seenivasagam, Rajkumar, Shaw, Richard, Simões, Joana Filipa Ferreira, Smart, Neil, Stewart, Grant D, Sullivan, Richard, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Vidya, Raghavan, Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Mann, Harvinder S, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Simoes, Joana FF, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Smart, Neil J, Moug, Susan, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Evans, Richard PT, Townend, Philip, McKay, Siobhan, Isaac, John, Satoi, Sohei, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Rey Biel, Juan, Batstone, Martin, Ganly, Ian, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Leung, Elaine YL, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Shylasree, TS, Ng, Joe, Fujiwara, Keiichi, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John S, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Augestad, Knut Magne, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Grecinos, Gustavo, Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jonker, Pascal, Kaafarani, Haytham MA, Keller, Debby, Kruijff, Schelto, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Richards, Toby, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, EuroSurg, Booth, Lesley, Runigamugabo, Emmy, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Tierney Weir, Carrie, Dajti, I, Allemand, C, Boccalatte, LA, Figari, M, Lamm, M, Larrañaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Ballester, AM, Tapper, KE, Zeff, N, Valenzuela, JI, Alurralde, C, Anastasio, J, Apas Perez de Nucci, A, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, García, JS, García, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Vasey, CE, Watson, EGR, Ip, C, Kealey, J, Lim, CSH, Sengupta, S, Ward, S, Wong, E, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, McLaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, Ahn, JH, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, McMillan, H, Moss, J, Pugliese, MJ, Richards, T, Seow, YTN, Thian, A, Viswambaram, P, Vo, UG, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Huang, L, Lam, YH, Nathan, A, Ong, BS, Ooi, E, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Hui, N, Izwan, S, Jeyarajan, E, Jordan, S, Liang, R, Lim, A, Nolan, GJ, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Sommerville, C, Townend, P, Von Papen, M, Wullschleger, M, Dawson, AC, Drane, A, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, Guerra, GR, Gerns, N, McGeorge, S, Riddell, A, Roberts, M, Rukin, N, Bolt, J, Buddingh, K, Dudi-Venkata, NN, Jog, S, Kroon, HM, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Sheahan, G, Swinson, B, Waldron, A, Walker, P, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, MW, Knowles, B, Mack, J, Read, M, Rowcroft, A, Wright, G, Lun, EWY, Lanner, M, Burtscher, J, Trivik-Barrientos, F, Königsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Öfner, D, Tsibulak, I, Holawe, S, Zimmermann, M, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Öhlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St. John, S, Walkes, K, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Ceelen, W, Pattyn, P, Van de putte, D, Van Nieuwenhove, Y, Van Ramshorst, G, Willaert, W, Bazzett-Matabele, L, Chiyapo, SP, Ramogola-Masire, D, Ramontshonyana, G, Seiphetlheng, A, Vuylsteke, P, Abdallah, EA, Aguiar Júnior, S, Baiocchi, G, Carvalho, GB, Coimbra, FJF, Kowalski, LP, Makdissi, F, Marques, N, Marques, T, Soares Dos Santos, S, Tirapelli Gonçalves, B, Vartanian, JG, Dos Reis, R, Camara, P, De Lima, RK, Della Giustina, E, Hoffmann, PV, Gatti, A, Nardi, C, Oliva, R, Nacif, L, Carvalho Ferro, C, Gomes Mendonça Ataíde, G, Lima Buarque, I, Lira dos Santos Leite, A, Pol-Fachin, L, Santos Bezerra, T, Maylson Ramos da Silva, A, Windson de Araújo Silvestre, D, Vieira Barros, A, Campbell, L, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, FR, Terra, RM, Faccini Teixeira, M, Kulcsar, MAV, Matos, LL, Nunes, KS, Laporte, G, Salem, M, Barakat Awada, J, Ijichi, TR, Kim, NJ, Marreiro, A, Muller, B, Nunes, R, Bodanese, B, Eidt, ER, Isoton, JC, Lemos Vieira da Cunha, M, Regina de Sampaio, L, Vendrame, C, Zeni, M, Zortéa, JA, Zortéa, MR, Sokolov, M, Kidane, B, Srinathan, S, Munro, A, Helyer, L, McKeen, D, Boutros, M, Caminsky, NG, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Cheng, D, MacNeil, SD, Martin, J, Dumitra, S, Kouyoumdjian, A, Schmid, S, Spicer, J, Agarwal, A, Brar, A, Dada, J, Dare, A, Hameed, U, Osman, F, Johnston, B, Russell, C, Groot, G, Persad, A, Pham, H, Wood, M, Ko, M, Rajendran, L, Demyttenaere, S, Garfinkle, R, Brown, C, Karimuddin, A, Lee, N, Liu, J, Madani Kia, T, Phang, PT, Raval, M, Tom, K, Abou-Khalil, J, Martel, A, Nessim, C, Stevenson, J, Al Riyami, S, Bali, K, Bigam, D, Dajani, K, Dell, A, Modolo, MM, Ramirez Nieto, P, Sepulveda, R, Molero, A, Bolbaran, A, Ruiz, I, Heredia, F, Bellolio, F, Besser, N, Grasset, E, Guaman, JO, Inzunza, M, Irarrázaval, MJ, Jarry, C, Quintana Martinic, M, Riquoir Altamirano, C, Romero Manqui, CA, Ruiz Esquide, M, Vargas Añazco, C, Almeciga, A, Fletcher, A, Merchan, A, Quijano, T, Sanabria, D, Arias-Amézquita, F, Cétares, C, Cortes Murgueitio, N, Gomez-Mayorga, JL, Herrera-Almario, G, Rodriguez, J, Iglesias, P, Puentes, LO, Calvache, JA, Orozco-Chamorro, CM, Rojas, DA, Sánchez-Gómez, A, Abadia, M, Acosta, J, Angel Aristizabal, J, Bonilla, A, Caicedo, L, Calderon Quiroz, PH, Cervera Bonilla, S, Diaz, S, Facundo, H, Garcia Mora, M, Guevara, O, Guzman, L, Herrera Mora, DR, Jimenez Ramirez, LJ, Lehmann, C, Manrique, E, Mariño, I, Medina, M, Pinilla Morales, RE, Puerto, A, Puerto Horta, J, Quintero, M, Rey Ferro, M, Saénz, A, Santana, D, Serrano, W, Suescun, O, Trujillo Sanchez, LM, Velasquez Cuasquen, BG, Mendoza Quevedo, J, Bacic, G, Karlovic, D, Kršul, D, Zelic, M, Luksic, I, Mamic, M, Bacic, I, Bakmaz, B, Coza, I, Dijan, E, Katusic, Z, Mihanovic, J, Morovic, D, Rakvin, I, Almezghwi, H, Arslan, K, Besim, H, Özant, A, Özçay, N, Frantzeskou, K, Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Yiallourou, A, Martinek, L, Skrovina, M, Straka, M, Szubota, I, Peteja, M, Žatecký, J, Javurkova, V, Klat, J, Antony, S, Avlund, T, Berg, KD, Borre, M, Christensen, P, Elkjær, MC, Ernst, A, Fensman, SK, Haldrup, M, Harbjerg, JL, Iversen, LH, Jensen, PT, Jeppesen, TD, Kjaer, DW, Kristensen, HØ, Lund, N, Maigaard Axelsen, S, Mekhael, M, Mikic, N, Ostenfeld, EB, Ebbehøj, AL, Krarup, P, Schlesinger, N, Smith, H, Batista, S, Crespo, A, Díaz, PJ, Rivas, R, Rodriguez-Abreu, J, Tactuk, N, El Kassas, M, Omar, W, Tawheed, A, Talaat, M, Abdelsamed, A, Azzam, AY, Salem, H, Seleim, A, Abdelmajeed, A, Abdou, M, Abosamak, NE, AL Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elnemr, M, Elsayed Hewalla, ME, Elsherbini, I, Essam, E, Ewedah, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, Qatora, MS, Ragab, M, Sabry, A, Saifeldin, H, Samih, A, Samir Abdelaal, A, Shehata, S, Shenit, K, Attia, D, Kamal, N, Osman, N, Abbas, AM, Abd Elazeem, HAS, Abd-Elkariem, AY, Abdelkarem, MM, Alaa, S, Ashraf, M, Ayman, A, Azizeldine, MG, Elkhayat, H, Emad Mashhour, A, Gaber, M, Hamza, HM, Hawal, I, Hetta, HF, K. Ali, A, M.elghazaly, S, Mohammed, MM, Monib, FA, Nageh, MA, Saad, A, Saad, MM, Shahine, M, Yousof, EA, Youssef, A, El-Deeb, M, Fawzy, M, Ghaly, G, Ibraheem, M, Eldaly, A, Esmail, E, ElFiky, M, Nabil, A, Alrahawy, M, Sakr, A, Soliman, H, Soltan, H, Amira, G, Sallam, I, Sherief, M, Sherif, A, Abdelrahman, A, Aboulkassem, H, Hamdy, R, Morsi, A, Sherif, G, Abdeldayem, H, Abdelkader Salama, I, Balabel, M, Fayed, Y, Sherif, AE, Elmorsi, R, Emile, S, Refky, B, Abd-elsalam, S, Badr, H, Elbahnasawy, M, Elzoghby, M, Essa, M, Gamal Badr, S, Ghoneim, A, Hamad, O, Hamada, M, Hammad, M, Hawila, A, Morsy, MS, Salman, S, Sarsik, S, Bekele, K, Kauppila, JH, Sarjanoja, E, Helminen, O, Huhta, H, Beyrne, C, Jouffret, L, Lugans, L, Marie-Macron, L, Chouillard, E, De Simone, B, Fredon, F, Roux, A, Bettoni, J, Dakpé, S, Devauchelle, B, Lavagen, N, Testelin, S, Boucher, S, Breheret, R, Gueutier, A, Kahn, A, Kün-Darbois, J, Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P, Chebaro, A, Drubay, V, El amrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, Pruvot, FR, Truant, S, Zerbib, P, Ballouhey, Q, Barrat, B, Fourcade, L, Laloze, J, Salle, H, Taibi, A, Tricard, J, Usseglio, J, Bergeat, D, Merdrignac, A, Le Roy, B, Perotto, LO, Scalabre, A, Gornes, H, Vaysse, C, Vergriete, K, Aimé, A, Ezanno, A, Malgras, B, Arnaud, AP, Fustec, E, Lavoue, V, Tesson, C, Bouche, P, Tzedakis, S, Cotte, E, Glehen, O, Lifante, J, Bendjemar, L, Braham, H, Charre, L, El Arbi, N, Morel-chevillet, L, Police, A, Villefranque, V, Volpin, E, D'Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B, Barbé, Y, Bardet, J, Barret, E, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Cathala, N, Cathelineau, X, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Macek, P, Mombet, A, Moumen, A, Pourcher, G, Rozet, F, Sanchez Salas, R, Seguin-givelet, A, Tribillon, E, Crenn, V, De Vergie, S, Duchalais, E, Espitalier, F, Ferron, C, Fragnaud, H, Malard, O, Regenet, 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Davies, E, Foulkes, R, Magowan, D, Nassa, H, Ooi, R, Price, C, Smith, L, Solari, F, Tang, A, Williams, G, Abd Kahar, NN, Al-Tamimi, Y, Bacon, A, Beasley, N, Catto, J, Chan, LH, Chew, D, Crank, M, Ilenkovan, N, Macdonald, M, Narice, B, Rominiyi, O, Saad, S, Sinha, S, Thompson, A, Varley, I, Brennan, P, Drake, T, Harrison, EM, Linder, G, Mayes, J, McGregor, R, Pasricha, R, Skipworth, RJE, Zamvar, V, Hawkin, P, Raymond, T, Ryska, O, Baron, R, Dunne, D, Gahunia, S, Halloran, C, Howes, N, McKinney, R, McNicol, F, Rajput, K, Russ, J, Sutton, R, Szatmary, P, Tan, JR, Whelan, P, Anzak, A, Banerjee, A, Fuwa, O, Hughes, F, Jayasinghe, JD, Knowles, C, Kocher, HM, Leal Silva, I, Ledesma, FS, Minicozzi, A, Navaratne, L, Patki, P, Rahman, R, Ramamoorthy, R, Sohrabi, C, Tanabalan, C, Thaha, M, Thakur, B, Venn, M, Yip, V, Baumber, R, Parry, J, Evans, S, Jeys, L, Morris, G, Parry, M, Ahmadi, N, Aresu, G, Barrett-Brown, ZM, Coonar, A, Durio Yates, H, Gearon, D, Hogan, J, King, M, Peryt, A, Pradeep, IS, Adishesh, M, Atherton, R, Baxter, K, Brocklehurst, M, Chaudhury, M, Krishnamohan, N, McAleer, J, Owens, G, Parkin, E, Patkar, P, Phang, I, Aladeojebi, A, Ali, M, Barmayehvar, B, Gaunt, A, Gowda, M, Halliday, E, Kitchen, M, Mansour, F, Nanjaiah, P, Zakai, D, Abbassi-Ghadi, N, Assalaarachchi, H, Currie, A, Flavin, M, Frampton, A, Hague, M, Hammer, C, Hopper, J, Horsnell, J, Humphries, S, Kamocka, A, Madhuri, TK, Preston, S, Singh, P, Stebbing, J, Tailor, A, Walker, D, Coomber, E, Jaunoo, S, Kennedy, L, Airey, A, Bunni, J, Crowley, R, Fairhurst, K, Frost, J, George, R, Lee, S, Mitchell, S, Phull, J, Richards, S, Aljanadi, F, Campbell, A, Glass, A, Hraishawi, I, Jones, M, McIlmunn, C, McIntosh, S, Mhandu, P, O'Donnell, C, Turkington, R, Al-Ishaq, Z, Bhasin, S, Bodla, AS, Burahee, A, Crichton, A, El-Ghobashy, A, Fossett, R, Pigadas, N, Rahman, E, Snee, D, Vidya, R, Yassin, N, Fountain, D, Hasan, MT, Karabatsou, K, Laurente, R, Pathmanaban, O, Barlow, C, Ding, D, Foster, J, Longstaff, L, Brett-Miller, C, Buruiana, FE, Al-mukhtar, A, Edwards, J, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E, Blair, J, Lakhiani, A, Parry-Smith, W, Sahu, B, Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Wilkin, R, Alzetani, A, Amer, K, Badran, A, Colvin, HV, Ethunandan, M, Sekhon, GK, Shakoor, Z, Shields, H, Singh, R, Talbot, T, Wensley, F, Lawday, S, Lyons, A, Newman, S, Chung, E, Hagger, R, Hainsworth, A, Hunt, I, Karim, A, Owen, H, Ramwell, A, Santhirakumaran, G, Smelt, J, Tan, C, Vaughan, P, Williams, K, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W, Bromage, S, Hall, J, Kaushik, V, Rudic, M, Vallabh, N, Zhang, Y, Harris, G, James, G, Kang, C, Lin, DJ, Rajgor, AD, Royle, T, Scurrah, R, Steel, B, Watson, LJ, Choi, D, Hutchison, R, Luoma, V, Marcus, HJ, May, R, Menon, A, Pramodana, B, Webber, L, Hayes, A, Jones, R, Sivarajah, G, Smith, M, Smrke, A, Strauss, D, Abouelela, FAM, Aneke, IA, Asaad, P, Brown, B, Collis, J, Duff, S, Khan, A, Moura, F, Taylor, M, Wadham, B, Warburton, H, Elmoslemany, T, Jenkinson, MD, Millward, CP, Zakaria, R, Mccluney, S, Parmar, C, Shah, S, Allison, J, Babar, MS, Bowen, J, Collard, B, Goodrum, S, Lau, K, Sargent, M, Scott, R, Thomas, E, Whitmore, H, Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A, Semple, C, Elhamshary, A, Imam, SMB, Kapriniotis, K, Kasivisvanathan, V, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, McEwen, R, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Arumugam, S, Ibrahim, B, Khan, K, Combellack, T, Hill, G, Jones, S, Kornaszewska, M, Mohammed, M, Tahhan, G, Valtzoglou, V, Blencowe, N, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, TA, Main, B, Olivier, J, Newton, C, Roswadowski, S, Ryan, N, Teh, E, West, D, Al-omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar, A, McEvoy, K, Naredla, P, Robertson, S, Sait, M, Sarma, DR, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Akhtar, MA, Brunt, A, McIntyre, J, Milne, K, Rashid, MM, Sgrò, A, Stewart, KE, Turnbull, A, Abou-Foul, AK, Gossedge, G, O'Donnell, S, Oldfield, F, Thomson, S, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Basnyat, P, Davis, H, Montauban, P, Shrestha, A, Agarwal, K, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Kolli, VS, Lala, AK, Leeson, S, Peevor, R, Seymour, Z, Consorti, E, Gonzalez, R, Grolman, R, Kwan-Feinberg, R, Liu, T, Merzlikin, O, Brown, A, Cooper, Z, Hirji, S, Jolissaint, J, Mahvi, D, Okafor, B, Raut, CP, Roxo, V, Salim, A, Bessen, S, Chen, L, Dagrosa, L, Fay, K, Fleischer, C, Hasson, R, Henderson, E, Leech, M, Loehrer, A, Markey, C, Paydarfar, J, Rosenkranz, K, Telma, K, Tocci, N, Wilkinson-Ryan, I, Bokenkamp, M, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, McElhinney, K, Olson, KA, Osterberg, EC, Riley, C, Srikanth, P, Barbour, J, Blazer, D, DiLalla, GA, Fayanju, O, Hwang, ES, Kahmke, R, Kazaure, H, Lazarides, A, Lee, W, Lidsky, M, Menendez, C, Moris, D, Plichta, J, Pradhan, MC, Puscas, L, Rice, HE, Rocke, D, Rosenberger, L, Scheri, R, Smith, BD, Stang, MT, Tolnitch, L, Turnage, K, Visgauss, J, Walton, FS, Watts, T, Zani, S, Farma, J, Cardona, K, Russell, MC, Clark, J, Kwon, D, Goel, N, Kronenfeld, J, Bigelow, B, Etchill, E, Gabre-Kidan, A, Jenny, H, Kent, A, Ladd, MR, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Kaafarani, H, Naar, L, Qadan, M, Brown, L, Ganly, I, Mullinax, JE, Alpert, N, Gillezeau, C, Miles, DDS, Taioli, E, Cha, DE, Gleeson, E, Horn, C, Sarpel, U, Gusani, N, Hazelton, J, Maines, J, Oh, JS, Ssentongo, A, Ssentongo, P, Bhama, A, Colling, K, Najarian, M, Azam, M, Choudhry, A, Marx, W, Abedin, Y, Arzumanov, G, Chokshi, R, Gabrilovich, S, Glass, N, Kalyoussef, E, Parvin-Nejad, FP, Roden, D, Stein, J, Suarez-Ligon, A, Tsui, G, Zhao, K, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, MK, Andaya, V, Bigay, K, Boeck, MA, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, BCS, Heaton, C, Hirose, K, Jablons, DM, Kirkwood, KS, Kornblith, LZ, Kratz, JR, Lee, RH, Miller, PN, Nakakura, EK, Nunez-Garcia, B, O'Donnell, RJ, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, MG, Wai, KC, Wustrack, R, Xu, MJ, Zimel, M, Beswick, D, Goddard, J, Manor, J, Song, J, Cioci, A, Pavlis, W, Rakoczy, K, Ruiz, G, Saberi, R, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, CL, Zafar, SN, Abdallah, M, Abouassi, A, Aigbivbalu, E, Eid, J, George, B, Kulkarni, G, Marwan, H, Mehdi, M, San Andrés, M, Sundaresan, J, Aoun, SG, Ban, VS, Batjer, HH, Bosler, K, Caruso, J, Sumer, B, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, PB, Hawkins, AT, Maiga, A, Ruzgar, NM, Sion, M, Ullrich, S, Laufer, J, Scasso, S, Al-Naggar, H, Al-Shehari, M, Almassaudi, A, Alsayadi, M, Alsayadi, R, Nahshal, M, Shream, S, AL-Ameri, S, and Aldawbali, M
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- 2021
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5. Premature Ovarian Failure: Fertility Challenge
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Vujović, Svetlana, Ivović, M., Tančić-Gajić, M., Marina, L. J., Arizanović, Z., Ivanišević, M., Barać, M., Micić, J., Barać, B., Micić, D., Genazzani, Andrea R., Series Editor, and Fauser, Bart C. J. M., editor
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- 2015
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6. Transsexualism: Endocrine Aspects
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Vujović, Svetlana, Ivović, M., Gajić, M. Tančić, Marina, L. J., Arizanović, Z., Barać, M., Popovic, S., Barać, B., Duišin, D., Milošević, A., Djordjević, M., Micić, D., Genazzani, Andrea R., Series Editor, and Fauser, Bart C. J. M., editor
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- 2015
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7. Carbohydrate and fatty acid metabolism responses to a graded maximal exercise test and recovery period in athletes and sedentary subjects
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Djelic, M., Mazic, S., Lazovic, B., Zikic, D., Sumarac-Dumanovic, M., and Micic, D.
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- 2015
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8. Growth hormone replacement normalizes impaired fibrinolysis: New insights into endothelial dysfunction in patients with hypopituitarism and growth hormone deficiency
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Miljic, D., Miljic, P., Doknic, M., Pekic, S., Stojanovic, M., Cvijovic, G., Micic, D., and Popovic, V.
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- 2013
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9. Assessing Temporal Changes in Genetic Diversity of Maize Hybrids Using RAPD Markers
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Bauer, I., Drinic, S. Mladenovic, Drinić, G., and Micić, D. Ignjatović
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- 2007
10. RUPTURE OF A PANCREATIC PSEUDOANEURYSM AS A CONSEQUENCE OF CHRONIC PANCREATITIS: CASE REPORT OF A SURGICAL EMERGENCY
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Perisic Zlatko, Brkic Dusan, Micic Dusan, Doklestic Vasiljev Krstina, Ceranic Miljan, Raspopovic Milos, Vasin Dragan, Hadzibegovic Adi, and Gregoric Pavle
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pseudoaneurysm ,rupture ,chronic pancreatitis ,emergency surgery ,Medicine (General) ,R5-920 - Abstract
Introduction: Pseudoaneurysms of the pancreaticoduodenal arcade are rare, accounting for approximately 2% of all visceral artery aneurysms. They typically arise as complications of chronic pancreatitis, peptic ulcer disease, trauma, pancreatic and biliary surgery, or pancreas transplantation. Diagnosis often occurs only after rupture, leading to life-threatening internal bleeding. Bleeding may occur within a pseudocyst, with blood passing through the Vater’s papilla into the digestive tract, or may result in the formation of a retroperitoneal hematoma that can rupture into the abdominal cavity, causing hemoperitoneum. The cell-saver is a tool that can be utilized for intraoperative blood cell salvage and autologous transfusions. Case Report: Our patient, a 54-year-old male, an untreated alcoholic with no prior medical history or documented treatment, presented to the Clinic for Emergency Surgery at the University Clinical Center of Serbia with a sudden onset of upper abdominal pain. A quick ultrasound of the abdomen was performed, followed by an urgent CT scan of the chest and abdomen, revealing a hematoma extending from the right retroperitoneum and mesentery of the intestine, measuring 150x109x180mm in diameter, with signs of active bleeding in the region beneath the pancreas, indicative of hemoperitoneum. Due to hemodynamic instability, accompanied by a drop in arterial blood pressure and hemoglobin levels, an urgent laparotomy was performed. Active bleeding was identified from a ruptured pseudoaneurysm originating from the pancreaticoduodenal arcade. Hemostasis was achieved followed by tamponade, and the tampons were removed 30 hours post-surgery. The patient remained hemodynamically stable thereafter, recovered well from the surgery, and was discharged home in good general condition. Intraoperatively, we utilized the Cell-saver to collect the patient’s blood and subsequently administered autologous transfusion. Conclusion: In patients with chronic pancreatitis presenting with sudden abdominal pain and hemodynamic instability accompanied by a drop in arterial pressure, hemoglobin, and hematocrit levels, the possibility of a ruptured pseudoaneurysm in the pancreatic or peripancreatic region should be considered. Timely diagnosis and prompt surgical intervention are crucial for a successful outcome. Effective collaboration among radiologists, anesthesiologists, and surgeons is essential. The utilization of the Cell-saver system significantly aids in maintaining cardiac output and hemodynamic stability in these patients.
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- 2024
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11. Increasing incidence of early percutaneous endoscopic gastrostomy (PEG) tube dislodgements in hospitalized patients
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Hakimian, D., Micic, D., McDonald, E., and Semrad, C.
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- 2023
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12. Obesity management: A clinician's perspective lečenje gojaznosti iz perspective kliničara
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Polovina Snežana, Šumarac-Dumanović Mirjana, and Micić Dragan
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obesity ,dietary treatment ,exercise ,anti-obesity drugs ,bariatric surgery ,low grade inflammation ,Pharmacy and materia medica ,RS1-441 - Abstract
The global epidemic of obesity has affected almost every country in the world, causing an enormous social and health burden. Although many countermeasures have been introduced against this epidemic, obesity is still on the rise. An important step in this area was made when obesity was classified as a disease. The recognition of obesity as a disease enables governments and state agencies to develop their own plans to curb the obesity epidemic. Obesity has been recognized as a problem from ancient times, and different measures have been suggested as solutions. Modern management of obesity is currently based on the following therapeutic principles: diet, exercise, psychological support, pharmacological treatment, and bariatric surgery. The history of pharmaceutical treatment is rather long and full of withdrawals of the drugs due to various reasons. New perspectives and promising results were introduced with a class of drugs based on incretins. These drugs were developed as agonists of gastrointestinal peptides in a mono form or a combination of two or three different agonists, achieving results similar to the effects of bariatric surgery. Currently, about 70 different therapeutical principles are in the process of development. Problems related to the drugs on the market are their high prices, limited capacity for production, and lack of experience regarding long-term use.
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- 2024
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13. A rare case report of autoimmune haemolytic anemia in a female child due to a Donath-Landsteiner antibody
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Radonjić, Z., Andrić, B., Šerbić, O., Mićić, D., Kuzmanović, M., Jovanović-Srzentić, S., and Dinić, R.
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- 2020
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14. HEPATIC METASTASIS OF THYMOMA: CASE REPORT OF A FAST-GROWING ABDOMINAL MASS IN A PREGNANT PATIENT
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Raspopovic Milos, Micic Dusan, Perisic Zlatko, Arsenijevic Vladimir, Brkic Dusan, and Gregoric Pavle
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thymoma ,metastasis ,liver ,pregnancy ,surgery ,Medicine (General) ,R5-920 - Abstract
Introduction: Thymomas are the most common primary mediastinal tumors originating from epithelial cells of the thymus, demonstrating epithelial differentiation. Pathologically, thymomas exhibit relatively slow growth and typically spread directly, with extremely rare occurrences of distant dissemination to extrathoracic organs. The precise incidence of such dissemination remains unknown. Distant metastases, particularly to the liver, are exceptionally rare, with only a few cases documented in the literature. Case Report: A 39-year-old woman, in her 31st week of gestation, presented with abdominal pain and discomfort. She underwent ultrasonography, followed by an urgent MRI of the abdomen due to a protruding tumor mass in the liver. Shortly after delivering a healthy baby via cesarean section, she was admitted to the hospital for a CT scan of the abdomen. The imaging revealed multiple focal changes in the liver parenchyma, exhibiting radiological characteristics consistent with focal nodular hyperplasia. Less likely differential diagnoses included adenomas or hemangiomas. Subsequently, she underwent staged hepatectomy, and the results of the pathological analysis confirmed the presence of type B thymoma metastases in the liver. Conclusion: According to the available data in the literature, metastatic thymomas are often identified in patients who have previously undergone treatment for the primary disease. Our patient did not have a history of thymectomy, as confirmed by postoperative chest scans. Onset of symptoms during late pregnancy guided our diagnosis, relying on overall clinical and radiological findings of the detected tumor. Our treatment involved staged hepatectomy post-childbirth, followed by adjuvant chemotherapy. Further comprehensive studies are essential to precisely understand neoplasm behaviors like thymoma for timely detection and effective treatment.
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- 2023
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15. Excitatory Amino Acid Receptors, Oxido-reductive Processes and Brain Oedema Following Transient Ischaemia in Gerbils
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Mršulja, B. B., Stanimirović, D., Mićić, D. V., Spatz, M., Reulen, Hans-J., editor, Baethmann, Alexander, editor, Fenstermacher, Joseph, editor, Marmarou, Anthony, editor, and Spatz, Maria, editor
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- 1990
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16. Glomerular involvement in myelodysplastic syndromes
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Bogdanović, R., Kuzmanović, M., Marković-Lipkovski, J., Ognjanović, M., Mićić, D., Stanković, I., Stajić, N., Nikolić, V., and Bunjevački, G.
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- 2001
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17. Insulin sensitivity and C-reactive protein levels after laparoscopic and open cholecystectomy - seven days follow-up
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Micić Dušan, Polovina Snežana, Lončar Zlatibor, Doklestić Krstina, Gregorić Pavle, Arsenijević Vladimir, Ćeranić Miljan, Micić Dragan, and Ivančević Nenad
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homa-ir ,crp ,laparoscopic cholecystectomy ,open cholecystectomy ,Medicine - Abstract
Introduction/Objective. The development of acute insulin resistance after surgery intervention is associated with the type and magnitude of operation and tissue injury. The aim of our study was to compare insulin sensitivity assessed by homeostatic model assessment of insulin resistance (HOMA-IR) and C-reactive protein (CRP) before and after laparoscopic and open cholecystectomy during seven days follow-up. Methods. In total, 92 patients were divided into two groups: laparoscopic cholecystectomy (Group 1) (n = 61) and open cholecystectomy (Group 2) (n = 31). Glucose, insulin and CRP levels were measured at day 0 and at postoperative days one, three and seven. Glucose, insulin and CRP were determined using commercial assay on Roche Cobas 6000 automated analyzer (Roche Diagnostics, Manheim, Germany). Results. There was no statistical difference between studied groups concerning age (p = 0.626), body mass index (p = 0.548), glucose (p = 0.947), insulin (p = 0.212), HOMA-IR (p = 0.390) and CRP (p = 0.546) at day 0. At day one, higher values of CRP were found in group 2 compared with group 1 (p = 0.046). At day three, significantly higher values of glucose and HOMA-IR were found in group 2 compared with group 1 (p = 0.025, p = 0.036, respectively). Conclusion. Increase in CRP precedes deterioration of insulin sensitivity measured by HOMA-IR after cholecystectomy. Impairment of insulin sensitivity was more pronounced at postoperative day three in group with open cholecystectomy. On the basis of our results, laparoscopic cholecystectomy induced less impairment in insulin sensitivity and lower inflammatory response.
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- 2023
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18. Quality of life in patients with diabetes - limited activity hinders women more
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Polovina Snežana, Terzić-Šupić Zorica, Micić Dušan, Todorović Jovana, Parapid Biljana, Milin-Lazović Jelena, Vasilijević Jelena, Mladenović-Marković Ana, and Bjelović Miloš
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diabetes mellitus ,health-related quality of life ,unhealthy days ,sex differences ,Medicine - Abstract
Introduction/Objective. Diabetes mellitus and its chronic complications impair quality of life (QoL) when compared to the one of the general population. The objective of this study was to determine the prevalence of > 14 unhealthy days per month among the patients with diabetes in Serbia and to determine the association of the socio-demographic characteristics and health characteristics with the total of > 14 unhealthy days. Methods. Serbian version of a generic self-administered questionnaire from Centers for Disease Control and Prevention (CDC-HRQOL-4) was used for data collection in all three levels of care. Results. The study involved 4898 patients with diabetes, 2283 (46.6%) men and 2611 (53.4%) women. Overall mean age was 57.3 ± 12.2 years with over one fifth (23.2 %) were younger than 50 years. Multivariate logistic regression analyses indicated that age > 65 (OR:1.575, 95%CI 1.100–2.256), being a woman (OR: 1.287, 95% CI 1.042–1.588), lower education (OR: 1.383, 95%CI 1.091–1.754), felt depressed ≥ 14 days (OR: 3.689, 95% CI 2.221–6.128), felt anxious ≥ 14 days (OR: 1.749, 95% CI 1.113–2.749), poor sleep ≥ 14 days (OR:2.161, 95%CI 1.569–2.988), fair or poor self-rated health ≥ 14 days (OR: 4.322, 95%CI 3.474–5.376) were associated with unhealthy days ≥ 14 days. The strongest negative association was observed between limited physical activity ≥ 14 days and a decrease in the QoL of people with diabetes (OR: 22.176, 95%CI 10.971–44.824). Conclusion. This study highlights association between impaired QoL in patients with diabetes and physical activity limitations. Limited physical activity is the factor with the greatest negative impact on the QoL particularly in older, less educated, and women with diabetes.
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- 2023
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19. The use of growth hormone (GH) secretagogues in the diagnosis of GH deficiency in humans
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Peino, R., Leal, A., Garcia-Mayor, R.V., Cordido, F., Micic, D., Kopeschaar, H., Dieguez, C., and Casanueva, F.F.
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- 1999
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20. Cerebral Blood Flow, Energy Utilization, Serotonin Metabolism, (Na, K)ATPase Activity, and Postischemic Brain Swelling
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Mršulja, B. B., Djuričić, B. M., Ueki, Y., Cahn, R., Cvejić, V., Martinez, H., Mićić, D. V., Stojanović, T., Spatz, M., Inaba, Yutaka, editor, Klatzo, Igor, editor, and Spatz, Maria, editor
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- 1985
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21. Pharmacological Approach to Postischemic Brain Edema in Gerbils
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Mršulja, B. B., Djuričić, B. M., Cvejić, Vesna, Mićić, D. V., Go, K. G., editor, and Baethmann, A., editor
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- 1984
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22. Phasic Recognition of Edema Caused by Ischemia
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Djuričić, B. M., Mićić, D. V., Mršulja, B. B., Go, K. G., editor, and Baethmann, A., editor
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- 1984
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23. The Ischemic and Postischemic Effect on the Activities of Cerebral Monoamine Oxidase, Cytochrome Oxidase and Acetylcholinesterase in Mongolian Gerbils
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Mićić, D., Abe, K., Rausch, W. D., Abe, T., Spatz, M., Spatz, Maria, editor, Mršulja, B. B., editor, Rakić, Lj. M., editor, and Lust, W. D., editor
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- 1980
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24. Studies on the Blood-Brain Barrier (BBB) to Monoamines
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Abe, T., Abe, K., Mićić, D., Djuričić, B. M., Mršulja, B. B., Spatz, M., Spatz, Maria, editor, Mršulja, B. B., editor, Rakić, Lj. M., editor, and Lust, W. D., editor
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- 1980
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25. Metabolic Patterns in Cerebral Capillaries
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Mršulja, B. B., Djuričić, B. M., Micic, D. V., Spatz, Maria, editor, Mršulja, B. B., editor, Rakić, Lj. M., editor, and Lust, W. D., editor
- Published
- 1980
- Full Text
- View/download PDF
26. Transport Phenomena in Cerebral Ischemia
- Author
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Spatz, M., Mićić, D., Fujimoto, T., Mršulja, B. B., Klatzo, I., Mršulja, B. B., editor, Rakić, Lj. M., editor, Klatzo, I., editor, and Spatz, Maria, editor
- Published
- 1979
- Full Text
- View/download PDF
27. The role of interleukin-4 and interleukin-5 Th2 cytokines in assessing severity and prognosis of acute pancreatitis
- Author
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Doklestić Krstina, Ivančević Nenad, Lončar Zlatibor, Micić Dušan, Ristić Miloš, Jovanović Bojan, and Gregorić Pavle
- Subjects
acute pancreatitis ,interleukin-4 ,interleukin-5: biomarker ,Medicine - Abstract
Introduction/Objective. Acute pancreatitis (AP) is a relatively common disease which in most patients has favorable course. However, in approximately 20% patients, the course of the disease is more severe with high mortality (40–50%). The evaluation of disease severity is now primarily based on protocols that includes clinical, laboratory, and radiographic diagnostic procedures, APACHE II score, Ranson score, CT index, and CT necrosis score. Key cells in the immunopathogenesis of AP are T-lymphocytes, and recent studies indicate the role of Th2 and their effector cytokines: interleukin (IL) -4 and interleukin (IL) -5. The purpose of our study was to determine the potential clinical value of IL-4 and IL-5 as biochemical markers for predicting development of severe, necrotizing form of acute pancreatitis with systemic complication such as systemic inflammatory response syndrome (SIRS). Methods. This prospective study included 240 patients hospitalized at The Clinic for Emergency Surgery of Clinical Center of Serbia as AP. Levels of IL-4 and IL-5 in serum were detected using commercial Bender Med Systems (BMS716FF) kits. Results. IL-4 and IL-5 were statistically significant increased on the second day of hospitalization with maximum values on the third day. In patients with severe AP complicated with necrosis and/or sepsis values were rising all through the seventh day. Conclusion. Levels of IL-4 and IL-5 in peripheral blood correlate with SIRS, Ranson score and clinical outcome in AP patients, therefore these cytokines are potential early biomarkers of disease progression and related complications.
- Published
- 2021
- Full Text
- View/download PDF
28. The impact of financial performance on workplace bullying and mistreatment in Serbian organizations
- Author
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Stankov Sanja, Poštin Jasmina, Konjikušić Marko, Jagodić-Rusić Aleksandra, and Mićić Daliborka
- Subjects
organizational financial performances ,salaries ,workplace bullying ,mistreatment ,serbia ,Business ,HF5001-6182 ,Finance ,HG1-9999 - Abstract
This paper presents the results of research into the impact of organizational financial performance items (and financial performance dimension) on workplace bullying and mistreatment. The research was conducted in organizations in Serbia, and the respondents were employees in these organizations. A total of 536 questionnaires were collected, which were valid for further analysis. The results showed that most of the observed financial performance items did not have a statistically significant impact on workplace bullying in organizations. However, the item Salaries; statistically significantly, strongly and negatively affects all observed workplace bullying dimensions and self-labelling (mistreatment) items. Thus, low employee salaries provide fertile ground for the development of workplace bullying. Conversely, with an increase in employee salaries, there is a decrease in all aspects of workplace bullying. The paper gives explanations for these phenomena. It is important for leaders and managers in business organizations to know the processes and relationships researched here. Special care should be taken in conditions of unfavourable organizational financial performance, and especially low salaries of employees.
- Published
- 2020
29. Diaphragmatic injuries: Therapy and diagnosis
- Author
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Mihajlovski Mirjana, Raspopović Miloš, Perišić Zlatko, and Micić Dušan
- Subjects
Medicine - Abstract
Traumatic diaphragmatic injury (DI) is a unique clinical entity that is usually occult and can easily be missed. Their delayed presentation can be due to the delayed rupture of the diaphragm or delayed detection of diaphragmatic rupture, making the accurate diagnosis of DI challenging to the trauma surgeons. Diaphragmatic injury may result within closed, blunt thoracoabdominal trauma or acute, penetrating thoracic, abdominal and thoracoabdominal trauma. Signs and symptoms of diaphragm injury are not specific and often remain undetected due to serious associated injuries, which distract surgeons' attention, complicating the diagnosis. Since it is not that frequent, little attention has been paid. For all above-mentioned, preoperative diagnosis is established with less than 1/2 of patients, with 44% on autopsy or intraoperatively accidentally, and in about 14% it was delayed even for several years. Many authors have tried, and Grimes has succeeded in introducing three phases of diaphragmatic injury describing acceptable system of detecting this organ injury: Acute phase - the diaphragmatic rupture, usually missed, because symptoms of associated injuries of organs prevail; Latent phase - with viscera partially protruding through diaphragmatic opening. It is characterised by mild symptoms of discomfort and uneasiness in hypohondrium and hemithorax of the injured side. Signs of dyspnoea and orthopnoea are moderate, and there might be a radiograph after chest X-ray; Obstructive phase - where the abdominal organs penetrate into the thorax and symptoms resulting from an obstruction or ischemia occur. It is usually characterised by Borchardt's Triad (strong epigastric pain, vomiting and the inability to pass a nasogastric tube), with X-ray indicating mediastinum shift, with obvious penetration of abdominal organs into the pleural space. Any diaphragmatic injury requires operational treatment, since this organ's injuries cannot spontaneously heal. Even injuries of smaller dimensions must be sutured to prevent outcome such as diaphragmatic hernia and its consequences.
- Published
- 2020
30. Acute surgical conditions in COVID-19 positive patients
- Author
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Lončar Zlatibor, Micić Dušan, Petrović Nataša, Laban Marija, Perišić Zlatko, Milenković Marija, and Gregorić Pavle
- Subjects
emergency surgery ,pandemic ,covid-19 ,organization ,surgical triage ,surgical procedures ,Medicine (General) ,R5-920 - Abstract
Since the beginning of the COVID-19 pandemic, many articles have been published on the subject of organising surgical activity in such conditions. The object of this article is to present the published literature in order to provide key suggestions for dealing with acute surgical problems during the pandemic. A systematic overview is presented of the most relevant articles dealing with COVID-19 and surgery, published between December 30th 2019 and April 30th 2020. The operating room is reserved solely for emergency and oncological procedures. The use of laparoscopy in COVID-19 positive patients should be assessed very carefully and critically because the virus is present in the pneumoperitoneum and its release through aerosol into the operating room can present a risk of contamination for the staff and the immediate environment. The possibility of delaying surgical procedures during the COVID-19 pandemic should be considered, until such time when the patient is no longer considered contagious or is no longer at risk of perioperative complications. If the surgery cannot be delayed, the surgeon in charge must minimize the risk of infection by including the smallest possible number of medical staff into the procedure and shortening the route the patient has to take through the hospital as much as possible. During the pandemic, open procedures take precedence. The purpose of this article is to provide surgeons with advice, so they can make decisions in the best possible interest of the patient and the surgical team, based on risk assessment for the patient (clinical presentation, comorbidity, hospital resources availability). For COVID-19 positive patients, as well as for those who are clinically highly suspected to be COVID-19 positive, nonoperative treatment is preferred if it is available and safe for the patient. If surgical procedures are necessary, personal protective equipment and all safety measures should be applied to protect the patient and the medical team.
- Published
- 2020
31. How Reliable Is the Euglycaemic Hyperinsulinemic Clamp Test for the Confirmation of Autonomous Endogenous Hyperinsulinemia ?
- Author
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Mićić, D., primary, Popović, Vera, additional, Šumarac, Mirjana, additional, Kendereški, Aleksandra, additional, Nešović, Milica, additional, Djordjević, P., additional, Manojlović, D., additional, and Mićić, J., additional
- Published
- 2009
- Full Text
- View/download PDF
32. A Comparison among the Effectiveness of Growth Hormone Suppression in Active Acromegaly of Bromocriptine and Long Acting Somatostatin Analogue (SMS 201–995)
- Author
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Popović, V., primary, Nešović, M., additional, Mićić, D., additional, Kendereški, A., additional, Djordjević, P., additional, Manojlović, D., additional, and Mićić, J., additional
- Published
- 2009
- Full Text
- View/download PDF
33. The Prolactin Response to TRH and Domperidone Does Not Differentiate Male Hypothalamic Hypogonadism and Constitutional Delay of Puberty
- Author
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Popović, V., primary, Milosević, Z., additional, Mićić, D., additional, Nesović, M., additional, Radmanović, S., additional, Kendereski, A., additional, Djordjević, A., additional, Manojlović, D., additional, and Mićić, J., additional
- Published
- 2009
- Full Text
- View/download PDF
34. Acute appendicitis during pregnancy
- Author
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Kaljević Goran, Pejić Nemanja, Micić Dušan, and Olujić Branislav
- Subjects
pregnancy ,acute appendicitis ,diagnostic procedures ,complication ,Medicine (General) ,R5-920 - Abstract
Acute appendicitis is the most common surgical emergency during pregnancy. It should be suspected when a pregnant woman complains of newly developed abdominal pain. No laboratory finding was found to be conclusive for acute appendicitis during pregnancy. A considerable percentage of fetal loss occurs after appendectomy in pregnant women during the first trimester, but also during the second. The combination of symptoms and clinical findings are crucial in making the diagnosis of acute appendicitis during pregnancy. Uterine contractions and diffuse or periumbilical abdominal pain, which migrates into the right lower quadrant are significantly more frequent among pregnant women with acute appendicitis than in pregnant women with other types of abdominal pathology. Abdominal pain, nausea, vomiting, leukocyte count, CRP and body temperature were of no help in establishing the correct diagnosis. The maternal morbidity and mortality were no higher than they were in other, non-pregnant individuals with acute appendicitis. However, the complications of the pregnancy itself were found to be significant.
- Published
- 2019
35. Laparoscopy in surgical treatment of acute cholecystitis
- Author
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Kaljević Goran, Olujić Branislav, Micić Dušan, and Stoimirov Ivan
- Subjects
laparoscopy ,acute cholecystitis ,complications ,operation duration ,Medicine (General) ,R5-920 - Abstract
In the presented randomized study, laparoscopic cholecystectomy has been performed on 50 patients with acute cholecystitis (experimental group) and 50 patients undergoing laparoscopic cholecystectomy as an elective procedure (control group). There were 35 male and 65 female patients. The average age of the patients was 59 years (56-68 years). In the experimental group, the laparoscopic cholecystectomy was performed within 72 hours from the moment of admission. Both groups were observed and data recorded as regards to demographic data, body mass index, presence or absence of fever, white blood cell count, CRP and ultrasound findings. The operation lasted 35 versus 50 minutes. In the experimental group 6% of the patients developed local complications, while the same happened to only 4% of the patients in the control group. There was a significant difference in the length of time spent at the hospital after the operation (5 days for the experimental group and only 2 for the control group). None of the patients died during this study. Laparoscopic cholecystectomy for treating acute cholecystitis in a carefully selected group of patients, performed during the initial hospital admission, is a safe method associated with acceptable morbidity. It should be performed as soon as possible, preferably within the first 72 hours after admission.
- Published
- 2019
36. Surgery and insulin resistance
- Author
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Micić Dušan, Polovina Snežana, Mijatović Srđan, Oluić Branislav, Arsenijević Vladimir, Lalić Nebojša, Đukić Vladimir, and Micić Dragan
- Subjects
Medicine - Abstract
Surgical intervention is an extremely high stress for the human body, leading to the occurrence of inflammation and insulin resistance. Insulin resistance is developing a few hours after the start of the operation, and the most pronounced right after its completion. Hyperglycemia and insulin resistance were recognized as a possible independent cause of complications in major abdominal surgery. Metabolic response to surgery or other types of trauma accelerating metabolism to the state of hypermetabolism, which implies an increase in oxidative processes and the acceleration of catabolic reactions, resulting in increased degradation of glycogen, fat and protein. Inflammatory response of the body in perioperative period is a protective mechanism which promotes better recovery, while excessive inflammatory response in severe tissue injury could contribute to development of complications and impaired wound healing. Tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6) and C-Reactive Protein (CRP) are, among the others, major regulators of the acute phase response to inflammation and tissue injury. Inflammatory response that is mediated by cytokines could be one of the molecular triggers for the metabolic response to surgery. Preoperatively reported insulin resistance, as a response to the starvation, in situations when food intake is reduced, insulin resistance is developed to provide limited supplies of carbohydrates used in tissues which depend of glucose intake, such as brain.
- Published
- 2018
37. Gut microbiota and diabetes remission after metabolic surgery
- Author
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Polovina Snežana, Šumarac-Dumanović Mirjana, Kendereški Aleksandra, Zorić Svetlana, Stamenković-Pejković Danica, Jeremić Danka, Micić Dušan, and Micić Dragan
- Subjects
Medicine - Abstract
Humans carry up to 200 bacterial species in the gastrointestinal tract. Important contribution of these genes is in carbohydrate degradation. The main task of the gut microbiota is digestion of food. The dominant gut bacteria are degradates of complex polysaccharides and releasing SCFA which are the sources for energy, cholesterol synthesis and gluconeogenesis. The mutual interaction of gut microbiota and host immune system is necessary for maintaining their symbiotic relationship. Microbial compositions differ in different metabolic conditions. Firmicutes are dominant in obese subjects while Akkermansia muciniphila which protect against adiposity, low grade inflammation in adipose tissue and insulin resistance is reduced in this population. Intestinal dysbiosis is associated with insulin resistance and diabetes type 2. Betaproteobacteria was highly enriched in diabetic population. The ratio of Bacteriodetes to Firmicutes and the Bacteroides-Prevotella group to the C.coccoides-E.rectale group are reduced. Gastrointestinal rearrangements after RYGB promote substantial changes on the gut microbiota. Gut microbota manipulation in favor of Akkermansia spp. may contribute in antidiabetic effect of metformin and could be potential treatment for T2D. Changes in gut bacteria after RYGB (Roux-en-Y gastric bypass) alter the body weight independent of other effects of bariatric/metabolic surgery. Mechanism for diabetes remission after bariatric surgery is still not clear. Besides change in incretin secretion and bile acid recirculation, potential mechanism is change of gut microbiota content. Possible improvement of glucose regulation following bariatric surgery may be related to butyrate and propionate production by some bacteria species, which influence glucose metabolism independently of bile acids recirculation.
- Published
- 2018
38. The role of anti-obesity drugs in the management of obese diabetics
- Author
-
Micić Dragan D., Polovina Snežana, and Micić Dušan D.
- Subjects
Medicine - Abstract
Obesity contributes to type 2 diabetes and worsens its control. 5-10% weight loss among obese diabetics significantly improves glucose control, lipids and blood pressure. Weight loss should be a key goal of diabetes care for all overweight and obese patients with type 2 diabetes. Adjunctive therapy with weight loss drugs is indicated among obese diabetics who can not achieve weight maintenance with lifestyle alone. Metformin use is associated with weight loss during management of diabetics. Metformin may reduce BMI by 5.3 % in comparison with placebo and it is considered as first-line agent in obese patient with type 2 diabetes. SGLT-2 inhibitors may reduce body weight for 3 to 5 kg during management of type 2 diabetes. Orlistat use resulted in a significant reduction of cumulative incidence of type 2 diabetes after 4 years of treatment of obese subjects. Phentermine and topiramate combination use in patients with diabetes and prediabetes results in greater reduction in HbA1c values and fewer prediabetes patients progression to type 2 diabetes. Therapy with combination of bupropione and naltrexone sustained-release among diabetic patients with obesity resulted in reduction of HbA1c and improvements in triglycerides and HDL cholesterol values. In BLOOM-DM study lorcaserin decreased weight by 4.5-5 % together with reductions in HbA1c . Liraglutide has a therapeutic potential for both obesity and type 2 diabetes, due to its dual benefits on body weight and glycemic control. Semaglutide is a new GLP-1 analogue that reduces HbA1c and body weight and improves obesity related complications. Combination of GLP-1/glucagon dual agonist theoretically may decrease food intake and body weight according the preclinical experience. In case where patient does not lose 5 % or more of his body weight on prescribed drug, after three months of treatment, therapy with this drug should be stopped and changed with some other.
- Published
- 2018
39. Hot flush values of gonadotropins and estradiol in menopause
- Author
-
Arizanović Zorana, Vujović Svetlana, Ivović Miomira, Tančić-Gajić Milina, Marina Ljiljana, Stojanović Miloš, and Micić Dragan
- Subjects
hot flushes ,menopause ,sex hormones ,Medicine - Abstract
Introduction/Objective. Hot flashes are one of the first clinical symptoms of menopause. The mechanism of hot flashes is still not fully understood. Changes in concentrations of the circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and other hormones can lead to thermoregulatory dysfunction. The aim of this study was to examine the association between dynamic changes in concentrations of sex hormones and the presence of vasomotor symptoms in menopausal women. Methods. The study involved 36 women divided into two groups: in the first group there were 24 women with hot flashes, BMI 26.16 ± 3.42 kg/m2; the control group comprised 12 women, BMI 26.82 ± 3.89 kg/m2. Data on the presence of hot flashes were based on medical history data. Venous blood samples were collected for the analyses of FSH, LH, prolactin, estradiol, progesterone, testosterone, sex hormone binding globulin, dehidroepiandrosteron sulfate, thyroid-stimulating hormone, and thyroxin. During the subjective feeling of hot flashes, three blood samples during the day and night were collected to determine the mean levels of FSH, LH, and estradiol in women with hot flashes. Results. Women with hot flashes had significantly higher prolactin (389.58 ± 123.69 mIU/L to 258.19 ± 122 mIU/L, p < 0.01) and dehydroepiandrosterone sulfate (3.60 ± 2.49 nmol/L vs. 1.88 ± 1.27 nmol/L, p < 0.05) levels, as well as lower mean values of FSH during hot flashes during the day (69.08 ± 28.84 IU/L vs. 107.18 ± 39.11 IU/L, p < 0.01) and night (60.72 ± 21.89 IU/L vs. 104.57 ± 38.06 IU/L, p < 0.01). Conclusion. .Women with hot flashes had significantly lower mean FSH levels during hot flashes during the day and night than the control group.
- Published
- 2018
- Full Text
- View/download PDF
40. Influence of IL-6, TNF-a and hs-CRP on insulin sensitivity in patients after laparoscopic cholecystectomy or open hernia repair
- Author
-
Micić Dušan, Lalić Nebojša, Đukić Vladimir, Stanković Sanja, Trajković Goran, Oluić Branislav, and Polovina Snežana
- Subjects
homa-ir ,hs-crp ,il-6 ,tnf-a ,surgery ,Biochemistry ,QD415-436 - Abstract
Background: The aim of this study was to investigate the influence of IL-6, TNF-a and hs-CRP on insulin sensitivity during postoperative follow-up in patients with laparoscopic cholecystectomy (LC) or open hernia repair (OHR). Methods: 65 patients were studied: after laparoscopic cholecystectomy (LC; n=40) or open hernia repair (OHR; n = 25). Glucose, insulin, hs-CRP IL-6 and TNF-a were determined at day 0 (before the operation) and at days 1, 3 and 7 (after the operation). Results: There were no difference between LC and OHR groups concerning age, BMI, glucose, insulin, hs-CRP IL-6 and TNF-a at day 0. hs-CRP increased at day 1, 3 and 7 vs. day 0 (p
- Published
- 2018
41. Prognostic value of preoperative neutrophil-to-lymphocyte ratio for prediction of severe cholecystitis
- Author
-
Micić Dušan, Stanković Sanja, Lalić Nebojsa, Đukić Vladimir, and Polovina Snežana
- Subjects
cholecystitis ,inflammatory biomarkers ,neutrophil-to-lymphocyte ratio ,prognosis ,Biochemistry ,QD415-436 - Abstract
Background: The predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with cholecystitis has not been established. The aim of this study was to investigate preoperative NLR in patients with cholecystitis and to identify a relevant NLR value that discriminates between simple and severe cholecystitis. Methods: This study included 136 patients who underwent laparoscopic cholecystectomy due to cholecystitis. The Receiver Operating Characteristic (ROC) analysis was performed to identify the most useful NLR cut-off value in relation to the severity of cholecystitis. The patients were divided into two groups according to the cut-off NLR value: high NLR group (> 4.18, n = 23) and low NLR group (< 4.18, n = 113). Severe cholecystitis was defined as a state which includes inflammation, empyema, gangrene, perforation of gallbladder, adhesions or difficulty in dissecting Calot's triangle. Results: In the high NLR group, severe cholecystitis (p 4.18 was significantly associated with severe cholecystitis. The preoperative NLR in patients undergoing cholecystectomy due to cholecystitis could be a useful surrogate marker of severe cholecystitis.
- Published
- 2018
42. Metabolic surgery and obesity related comorbidities
- Author
-
Polovina Snežana, Micić Dušan, Bjelović Miloš, Šumarac-Dumanović Mirjana, and Kendereški Aleksandra
- Subjects
bariatric surgery ,obesity ,comorbidity ,fatty liver ,sleep apnea syndromes ,hypertension ,neoplasms ,Medicine (General) ,R5-920 - Abstract
nema
- Published
- 2018
- Full Text
- View/download PDF
43. 3-CARBOMETHOXY FENTANYL: SYNTHESIS, PHARMACOLOGY AND CONFORMATIONAL ANALYSIS
- Author
-
Μίćονίć, I.V., primary, Ivanovic, M. D., additional, Vućković, S., additional, Jovanović-Mićić, D., additional, Beleslin, D., additional, Dośen-Mićović, Lj., additional, and Kiricojević, V. D., additional
- Published
- 1998
- Full Text
- View/download PDF
44. Central muscarinic M-1 receptors in the regulation of the arterial blood pressure in cats
- Author
-
Veljković, S., primary, Japundzˇić-Zˇigon, N., additional, Samardzˇić, R., additional, Jovanović-Mićić, D., additional, and Beleslin, D.B., additional
- Published
- 1995
- Full Text
- View/download PDF
45. Effects of atropine and pirenzepine on the pendular movements of the rabbit isolated colon
- Author
-
Radenković, M., primary, Jovanović-Mićić, D., additional, Samardzˇić, R., additional, and Beleslin, D.B., additional
- Published
- 1995
- Full Text
- View/download PDF
46. 418 Superoxide dismutase activity in ischaemic conditions: Brain and myocardial vascular ischaemia
- Author
-
Aco Jovicic, Rosa Mihajlovic, M. Ninkovic, Mićić D, and Marina Jovanovic
- Subjects
medicine.medical_specialty ,Neuropsychology and Physiological Psychology ,business.industry ,Physiology (medical) ,General Neuroscience ,Internal medicine ,Cardiology ,Ischemia ,Medicine ,Superoxide dismutase activity ,business ,medicine.disease - Published
- 1998
47. 58 PREMATURE OVARIAN FAILURE: EMAS RECOMMENDATIONS AND NEW PERSPECTIVES
- Author
-
Vujovic, S.Z., Ivovic, M., Tancic-Gajic, M., Ivanisevic, M., Marina, L., Barac, M., Arizanovic, Z., and Micic, D.
- Published
- 2012
- Full Text
- View/download PDF
48. Non-surgical complications following bariatric surgery
- Author
-
Polovina Snežana, Micić Dragan, Micić Dušan, Šumarac-Dumanović Mirjana 0000-0002-6216, Kendereški Aleksandra, Micić J., Stamenković-Pejković Danica, Cvijović Goran, Zorić S., Jeremić D., and Bjelović Miloš
- Subjects
anaemia and bariatric surgery ,bone and bariatric surgery ,fertility and bariatric surgery ,addiction and bariatric surgery ,Medicine - Abstract
Bariatric surgery is the most efficient treatment for obesity and comorbidities. This treatment modality is the most potent for weight reduction with long-term weight maintenance and positive metabolic effects. The effect on weight loss and possible side effect depends of type of surgery. Micro and macronutrient deficiencies can occur after malapsorptive procedures. Iron deficiency occurs in almost half of patients following RYGB (Roux-en-Y gastric bypass). The main causes of iron deficiency are insufficient meat ingestion and lack of hydrochloric acid after removal of pylorus. B12 deficiency occured 6 months after RYGB in patients with oral supplementation of B12. Bone turnover increased three months after RYGB, and the levels of bone turnover markers increased 200% in next 12-18 months. Impaired vitamin D absorption leads to decreased calcium absorption and secondary hyperparathyroidism with lower bone mineral density. After the bariatric surgery, testosterone level becomes higher and all sexual quality indicators improving. Malapsorptive procedures with nutritive deficiency can cause oligo-astenozooteratospermia and male infertility. Due to the same reason pregnancy is not recommended in the first year bariatric surgery. Possible side effect of pregnancy within 12 months after surgery is fetal growth retardation. There is twice higher incidence for developing alcohol or other addition after bariatric surgery then in non-operated obese patients. The frequency of depressive episodes and suicide attempt is higher after bariatric surgery.
- Published
- 2017
- Full Text
- View/download PDF
49. Effect of alcohol on insulin secretion and viability of human pancreatic islets
- Author
-
Nikolić Dragan, Micić Dragan, Dimitrijević-Srećković Vesna, Kerkez Mirko, and Nikolić Biljana
- Subjects
alcohol ,insulin secretion ,viability ,insulin resistance ,type 2 diabetes ,Medicine - Abstract
Introduction/Objective. There are controversial data in the literature on the topic of effects of alcohol on insulin secretion, apoptosis, and necrosis of the endocrine and exocrine pancreas. The goal of this research was to determine how alcohol affects the insulin secretion and viability of human adult pancreatic islets in vitro during a seven-day incubation. Methods. Human pancreatic tissue was digested with Collagenase XI, using a non-automated method. Cultures were incubated in Roswell Park Memorial Institute (RPMI) medium containing alcohol (10 μl of alcohol in 100 ml of medium). Insulin stimulation index (SI) and viability of the islets were determined on the first, third, and seventh day of cultivation. Results. Analysis of the viability of the islets showed that there wasn’t significant difference between the control and the test group. In the test group, viability of the cultures declined with the time of incubation. SI of the test group was higher compared to the control group, by 50% and 25% on the first and third day of cultivation, respectively. On the seventh day, insulin secretion was reduced by 25%. The difference was not statistically significant (p > 0.05). In the test group, significant decline in insulin secretion was found on the third and seventh day of incubation (p ≤ 0.05). Conclusion. Alcohol can increase or decrease insulin secretion of islets cultures, which may result in an inadequate response of pancreatic β-cells to blood glucose, leading to insulin resistance, and increased risk of developing type 2 diabetes. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 41002]
- Published
- 2017
- Full Text
- View/download PDF
50. Late vitamin K deficiency bleeding despite intramuscular prophylaxis at birth - is there a need for additional supplementation?
- Author
-
Martić Jelena, Pejić Katarina, Veljković Dobrila, Rakonjac Zorica, Kuzmanović Miloš, Mićić Dragan, Vušurović Veselin, Kalanj Jasna, and Janković Borisav
- Subjects
Vitamin K ,late vitamin K deficiency bleeding ,intramuscular prophylaxis ,Medicine - Abstract
Introduction/Objective. Vitamin K deficiency is common in newborn infants and without prophylaxis there is a risk of vitamin K deficiency bleeding (VKDB). The most frequent prophylactic approach is an intramuscular (IM) injection of vitamin K1 immediately after birth. Its efficiency to prevent late VKDB has been recently questioned by several reports. Based on our experience, we discuss the need for additional vitamin K1 supplementation after its IM administration at birth. Methods. We present a retrospective review of 12 infants, 11 with confirmed and one with probable late VKDB despite IM prophylaxis at birth, who were treated in the two largest tertiary care pediatric hospitals in Serbia during the last 15 years. Results. All the patients were exclusively breastfed. In 11 patients, daily weight gain was normal or increased, and one patient had failure to gain weight. Six infants were previously healthy, three infants received antibiotics prior to bleeding, and in two diarrhea and cholestasis, respectively, existed previously. An intracranial bleeding was documented in nine infants, four of whom died. Conclusion. Low content of phytomenadione in human milk could occasionally be attributed to late VKDB despite postnatal IM injection of vitamin K1 in otherwise healthy, exclusively breastfed infants. This might be aggravated by transient disturbance of vitamin K turnover due to antibiotic use, acute diarrhea, or transient cholestasis. We suggest that an additional vitamin K1 supplementation after postnatal IM prophylaxis could be justified in exclusively breastfed infants.
- Published
- 2017
- Full Text
- View/download PDF
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