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899 results on '"Mhiri Chokri"'

1. Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis

Author

Feki Sawsan, Naifar Manel, Dammak Mariem, Majdoub Sabrina, Sakka Salma, Ben Ali Yesmine, Hachicha Hend, Mhiri Chokri, Ayadi Fatma, and Masmoudi Hatem

Subjects
multiple sclerosis, vitamin d, inflammatory cytokines, csf oligoclonal bands, Biochemistry, QD415-436
Abstract

Background: During the last decade, vitamin D (VitD) has become a topic of interest in immune regulation, especially in multiple sclerosis (MS) disease. Amongst the wide range of effects reported for this vitamin on the immune system, a regulatory role on cytokines production has been described. Our aim is to analyze the status of VitD and its correlation with the circulating inflammation and the intrathecal humoral response during MS. Methods: We analyzed samples of 318 individuals: 108 MS patients and 210 controls. Determination of 25-(OH) VitD3 level in serum was made using electrochemiluminescence method. Circulating inflammatory cytokines (IL-6, IL-8, IL-10, TNF-a, IL12p70 and IL-1b) were investigated using Cytometer Bead Array Technology. The central humoral response was characterized using CSF isofocusing test and IgG Index calculation. Results: As expected, mean value of VitD was significantly lower in MS group (26 nmol/L) than in control group (34.75 nmol/L) (p=0.002), with a severe deficiency in 67% of MS patients. Mean value of VitD was significantly lower in MS female patients. Regarding cytokines, mean value of TNFa was significantly higher in MS patients with oligoclonal bands of IgG in the CSF. IL6 was positively correlated with IgG level in serum of MS patients. Conclusions: Our results support the association of VitD deficiency with MS, especially in female patients of our region. However, the vitamin level seems to not correlate with inflammatory cytokines nor with disability. Interestingly, TNFa and IL6 levels were correlated with the intrathecal synthesis of IgG and the circulating IgG level, respectively.

Published
2023
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3. A challenging entity: multiple sclerosis or collagen tissue disorders: A case series of 6 patients

Author

Raida Ben Salah, Yosra Cherif, Feten Frikha, Chifa Dammak, Mouna Snoussi, Moez Jallouli, Sameh Marzouk, Mhiri Chokri, and Zouhir Bahloul

Subjects
multiple sclerosis, autoimmne disease, optic neurits, Internal medicine, RC31-1245
Abstract

Background: Multiple sclerosis and other demyelinating processes are sometimes difficult to differentiate from the neurological involvement in autoimmune diseases. Distinguishing multiple sclerosis from other lesions due to autoimmune diseases is crucial to avoid unsuitable or delayed treatments. Methods: Charts of 6 patients diagnosed with mimicking multiple sclerosis between 1996 and 2014 were retrospectively assessed. Results: The mean age at diagnosis was 35±7 years. The most commonly neurological manifestation at onset was paraparesis due to transverse myelopathy and uni/bilateral optic neuropathy. All our patients suffered from recurrent episodes of optic neuritis with a mean lag time of 12 months. Other initial presenting neurological manifestations in our patients included ataxic gait and pyramidal syndrome. Systemic symptoms occurred a long time before or after their initial neurological presentation. All patients had numerous T2 hyperintense lesions in the periventricular white matter and spinal cord with contrast enhancement. The antibodies tests revealed the presence of significant amounts of anti-nuclear antibodies. The anti-phospholipid antibodies were negative in all patients. All patients were treated with corticosteroid therapy and neurological features were cleared in all cases. Conclusion: Multiple sclerosis, other myelitis and optic neuritis, are sometimes difficult to differentiate from CNS involvement in autoimmune disease. Indeed, the clinical presentation, immunological profile and MRI lesions may be similar.

Published
2017

5. A Hybrid Approach Using 2D CNN and Attention-Based LSTM for Parkinson’s Disease Detection from Video

Author

Krichene, Emna, Jarraya, Islem, Dhieb, Thameur, Mahfouf, Zohra, Neji, Mohamed, Farhat, Nouha, Smaoui, Emna, Hamdani, Tarek M., Damak, Mariem, Mhiri, Chokri, Chabchoub, Habib, Ouahada, Khmaies, Alimi, Adel M., Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nguyen, Ngoc Thanh, editor, Franczyk, Bogdan, editor, Ludwig, André, editor, Núñez, Manuel, editor, Treur, Jan, editor, Vossen, Gottfried, editor, and Kozierkiewicz, Adrianna, editor

Published
2024
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16. Cerebral rheumatoid vasculitis: a case report

Author

Akrout Rim, Bendjemaa Samar, Fourati Hela, Ezzeddine Mariem, Hachicha Imène, Mhiri Chokri, and Baklouti Soufiene

Subjects
Cerebral vasculitis, Rheumatoid arthritis, Cerebral magnetic resonance imaging, Central nervous system, Medicine
Abstract

Abstract Introduction Central nervous system involvement in rheumatoid arthritis is infrequent. The most frequent neurological manifestations of rheumatoid arthritis are peripheral neuropathy and cervical spinal cord compression due to subluxation of the cervical vertebrae. Cerebral rheumatoid vasculitis is an uncommon and serious complication which can be life-threatening. Case presentation A 52-year-old North African Tunisian Caucasian woman presented with a six-week history of headache. She had suffered seropositive and destructive rheumatoid arthritis for nine years without any extra-articular complications. Magnetic resonance imaging of the brain with the T2 sequence showed high-intensity signal images at the frontal and parietal cortico-subcortical junction suggesting hemispheric vasculitis. Conclusions Cerebral vasculitis is an infrequent complication in rheumatoid arthritis which is associated with high morbidity and in some cases can be life-threatening. Early assessment and a high index of suspicion to recognize such complications are essential in managing these patients.

Published
2012
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24. Ischemic Stroke in Young Tunisian Adults

Author

Turki, Dhaker, primary, Sakka, Salma, additional, Mbarek, Lamia, additional, Triki, Faten, additional, Ben jmea, Mounir, additional, Moalla, Khadija, additional, Marzouk, Sameh, additional, Turki, Olfa, additional, Megdiche, Fatma, additional, Kallel, Choumous, additional, Damak, Mariem, additional, and Mhiri, Chokri, additional

Published
2024
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25. Épilepsie et mariage

Author

Zouari, Amal, primary, Daoud, Sawsan, additional, Sakka, Salma, additional, Bouattour, Nadia, additional, Moalla, Khadija Sonda, additional, Dammak, Mariem, additional, and Mhiri, Chokri, additional

Published
2024
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49. Ocular myasthenia gravis

Author

Rekik, Mona, primary, Abid, Imen, additional, Djebbi, Ons, additional, Moalla, Khadija, additional, Amor, Saloua Ben, additional, Trigui, Amira, additional, and Mhiri, Chokri, additional

Published
2023
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