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1. Active alcohol consumption is associated with acute-on-chronic liver failure in Hispanic patients

Author

Idalsoaga, Francisco, Díaz, Luis Antonio, Fuentes-López, Eduardo, Ayares, Gustavo, Valenzuela, Francisco, Meza, Victor, Manzur, Franco, Sotomayor, Joaquín, Rodriguez, Hernán, Chianale, Franco, Villagrán, Sofía, Schalper, Maximiliano, Villafranca, Pablo, Veliz, Maria Jesus, Uribe, Paz, Puebla, Maximiliano, Bustamante, Pablo, Aguirre, Herman, Busquets, Javiera, Roblero, Juan Pablo, Mezzano, Gabriel, Hernandez-Tejero, Maria, Arrese, Marco, and Arab, Juan Pablo

Published
2024
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2. Rectal colonization by resistant bacteria increases the risk of infection by the colonizing strain in critically ill patients with cirrhosis

Author

Prado, Verónica, Hernández-Tejero, María, Mücke, Marcus M., Marco, Francesc, Gu, Wenyi, Amoros, Alex, Toapanta, David, Reverter, Enric, Peña-Ramirez, Carlos de la, Altenpeter, Laura, Bassegoda, Octavi, Mezzano, Gabriel, Aziz, Fátima, Juanola, Adria, Rodríguez-Tajes, Sergio, Chamorro, Vanessa, López, David, Reyes, Marta, Hogardt, Michael, Kempf, Volkhard A.J., Ferstl, Philip G., Zeuzem, Stefan, Martínez, José Antonio, Vila, Jordi, Arroyo, Vicente, Trebicka, Jonel, and Fernandez, Javier

Published
2022
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3. THU-056 Soluble PD-L1 levels as predictors of ACLF in decompensated cirrhosis: findings from two independent cohorts

Author

Juanola, Adrià, primary, Mezzano, Gabriel, additional, Pose, Elisa, additional, Moreta, Maria Jose, additional, Ribera, Jordi, additional, Castillo, Joaquin Andrés, additional, Jimenez-Esquivel, Natalia, additional, Perez-Guasch, Martina, additional, Rubio, Ana Belén, additional, Cervera, Marta, additional, Carol, Marta, additional, Nadal, Ruth, additional, Gratacós-Ginès, Jordi, additional, Soria, Anna, additional, Fabrellas, Núria, additional, Morales-Ruiz, Manuel, additional, Coll, Mar, additional, Graupera, Isabel, additional, Solà, Elsa, additional, and Ginès, Pere, additional

Published
2024
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4. THU-170-YI Paris II criteria are better than Poise to predict liver-related complications after second line therapy in patients with primary biliary cholangitis

Author

Hernàndez-Èvole, Helena, primary, Olivas, Ignasi, additional, Manzorro, Alvaro Giménez, additional, Llinás, Margarita Sala, additional, Villagrasa, Ares, additional, García-Retortillo, Montserrat, additional, Sobenko, Natalia, additional, Muñoz, Beatriz Mateos, additional, Horta, Diana, additional, Mezzano, Gabriel, additional, Castello, Inmaculada, additional, Villamil, Alejandra, additional, Salcedo, Magdalena, additional, Londoño, María Carlota, additional, and Rodriguez-Tajes, Sergio, additional

Published
2024
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8. Active alcohol consumption is associated with Acute-on-Chronic Liver Failure in Hispanic patients

Author

Idalsoaga, Francisco, primary, Díaz, Luis Antonio, additional, Fuentes-López, Eduardo, additional, Ayares, Gustavo, additional, Valenzuela, Francisco, additional, Meza, Victor, additional, Manzur, Franco, additional, Sotomayor, Joaquín, additional, Rodriguez, Hernán, additional, Chianale, Franco, additional, Villagrán, Sofía, additional, Schalper, Maximiliano, additional, Villafranca, Pablo, additional, Veliz, Maria Jesus, additional, Uribe, Paz, additional, Puebla, Maximiliano, additional, Bustamante, Pablo, additional, Aguirre, Herman, additional, Busquets, Javiera, additional, Roblero, Juan Pablo, additional, Mezzano, Gabriel, additional, Hernandez-Tejero, Maria, additional, Arrese, Marco, additional, and Arab, Juan Pablo, additional

Published
2023
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9. O- 23 STRATEGIES TO ELIMINATE HEPATITIS C VIRUS INFECTION IN THE AMERICAS

Author

Díaz, Luis Antonio, García, Sergio, Khan, Rayan, Ayares, Gustavo, Uribe, Javier, Idalsoaga, Francisco, Fuentealba, José Miguel, Fuentes, Eduardo, Maldonado, Katherine, Lazo, Mariana, Ferreccio, Catterina, Mendizabal, Manuel, Dirchwolf, Melisa, Guerra, Patricia, Oliveira, Claudia P., Guimarães, Mario, Reis, Mario, Sebastiani, Giada, Brahmania, Mayur, Ramji, Alnoor, Niazi, Mina, Ko, Hin Hin, Feld, Jordan, Restrepo, Juan Carlos, Ramírez, Wagner, Alfaro, Omar, Castellanos-Fernández, Marlen, Carrera, Enrique, Ayala, José Roberto Aguirre, Sánchez, Abel, Sánchez, Marco, Andara, María Teresa, Castro, Graciela, Chavez-Tapia, Norberto, Mendez-Sanchez, Nahum, Adames, Enrique, Lombardo, Julissa, Girala, Marcos, Morán, Elías, Padilla-Machaca, Martin, Díaz, Javier, Tagle, Martín, Mainardi, Victoria, Hernandez, Nelia, Martínez, Edmundo, Alvarado-Tapias, Edilmar, Leon, Roberto, Talal, Andrew, Thomas, Emmanuel, Springer, Sandra, Garcia-Saenz-de-Sicilia, Mauricio, Zhang, Wei, Bajaj, Jasmohan, Tapper, Elliot B., Izzy, Manhal J., Gish, Robert G., Attar, Bashar, Cotter, Thomas G., Lucey, Michael R., Kamath, Patrick S., Singal, Ashwani K., Bataller, Ramón, Mezzano, Gabriel, Soza, Alejandro, Lazarus, Jeffrey V., Arrese, Marco, and Arab, Juan Pablo

Published
2024
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11. Strategies to eliminate hepatitis C virus infection in the Americas

Author

Diaz, Luis Antonio, primary, García, Sergio, additional, Khan, Rayan, additional, Ayares, Gustavo, additional, Monasterio, Javier Uribe, additional, Idalsoaga, Francisco, additional, Fuentes, Eduardo, additional, Medel, María Paz, additional, Ramirez, Carolina, additional, Lazo, Mariana, additional, Ferreccio, Catterina, additional, Mendizabal, Manuel, additional, Dirchwolf, Melisa, additional, Guerra, Patricia, additional, Oliveira, Claudia, additional, Pessoa, Mário, additional, Álvares-da-Silva, Mario, additional, Sebastiani, Giada, additional, Brahmania, Mayur, additional, Ramji, Alnoor, additional, Niazi, Mina, additional, Ko, Hin HIn, additional, Feld, Jordan J., additional, Restrepo, Juan Carlos, additional, Ramirez, Wagner, additional, Alfaro, Omar, additional, Castellanos-Fernández, Marlen, additional, Carrera, Enrique, additional, Aguirre, Jose Roberto, additional, Maldonado Cardona, Katherine Emilia, additional, Sanchez, Abel, additional, Sánchez, Marco, additional, Andara, Maria Teresa, additional, Castro-Narro, Graciela, additional, Chávez-Tapia, Norberto Carlos, additional, Méndez-Sánchez, Nahum, additional, Adames, Enrique, additional, Lombardo, Julissa, additional, Girala, Marcos, additional, Morán, Elias, additional, Padilla, P. Martin, additional, Diaz-Ferrer, Javier, additional, Tagle, Martin, additional, Mainardi, Victoria, additional, Hernandez, Nélia, additional, Martinez, Edmundo, additional, Alvarado-Tapias, Edilmar, additional, Robert, Leon, additional, Hernandez-Tejero, Maria, additional, De Sicilia, Mauricio Garcia Saenz, additional, Zhang, Wei, additional, Bajaj, Jasmohan S., additional, Tapper, Elliot, additional, Izzy, Manhal, additional, Gish, Robert G., additional, Attar, Bashar, additional, Cotter, Thomas, additional, Kamath, Patrick S., additional, Singal, Ashwani, additional, Bataller, Ramon, additional, Mezzano, Gabriel, additional, Soza, Alejandro, additional, Lazarus, Jeffrey, additional, Arrese, Marco, additional, and Arab, Juan Pablo, additional

Published
2023
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12. Serum PDL1 levels are associated with increased risk of bacterial infections in non-hospitalised patients with cirrhosis

Author

Juanola, Adria, primary, Mezzano, Gabriel, additional, Incicco, Simone, additional, Pose, Elisa, additional, Blaya, Delia, additional, Solé, Cristina, additional, Jimenez-Esquivel, Natalia, additional, Castillo, Joaquin Andrés, additional, Ribera, Jordi, additional, Almodovar, Xènia, additional, Perez, Martina, additional, Rubio Garcia, Ana Belen, additional, Cervera, Marta, additional, Carol, Marta, additional, Nadal, Ruth, additional, Arslanow, Anita, additional, Gratacos, Jordi, additional, Soria, Anna, additional, Fabrellas, Núria, additional, Angeli, Paolo, additional, Morales-Ruiz, Manuel, additional, Coll, Mar, additional, Graupera, Isabel, additional, Piano, Salvatore, additional, Solà, Elsa, additional, and Ginès, Pere, additional

Published
2023
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13. OP-4 IMPLEMENTATION OF A RE-LINKAGE TO CARE STRATEGY IN PATIENTS WITH CHRONIC HEPATITIS C WHO WERE LOST TO FOLLOW-UP IN LATIN AMERICA

Author

Mendizabal, Manuel, primary, Thompson, Marcos, additional, Gonzalez-Ballerga, Esteban, additional, Anders, Margarita, additional, Castro-Narro, Graciela E, additional, Pessoa, Mario G, additional, Cheinquer, Hugo, additional, Mezzano, Gabriel, additional, Palazzo, Ana, additional, Ridruejo, Ezequiel, additional, Descalzi, Valeria, additional, Velasco, Jose A Velarde-Ruiz, additional, Marciano, Sebastian, additional, Muñoz, Linda, additional, Schinoni, Maria I, additional, Poniachik, Jaime, additional, Perazzo, Rosalía, additional, Cerda, Eira, additional, Fuster, Francisco, additional, Varon, Adriana, additional, García, Sandro Ruiz, additional, Soza, Alejandro, additional, Cabrera, Cecilia, additional, Gomez-Aldana, Andres J, additional, Beltrán, Flor de María, additional, Gerona, Solange, additional, Cocozzella, Daniel, additional, Bessone, Fernando, additional, Hernández, Nelia, additional, Alonso, Cristina, additional, Ferreiro, Melina, additional, Antinucci, Florencia, additional, Torre, Aldo, additional, Moutinho, Bruna D, additional, Borges, Silvia Coelho, additional, Gomez, Fernando, additional, Murga, Maria Dolores, additional, Piñero, Federico, additional, Sotera, Gisela F, additional, Ocampo, Jhonier A, additional, Mollinedo, Valeria A Cortés, additional, Girala, Marcos, additional, Montes, Pedro, additional, Ratusnu, Natalia, additional, Zuñagua, Claudia A, additional, Castillo, Lida, additional, Barradas, Mauricio Castillo, additional, Chávez, Rocío, additional, Ivantes, Cláudia, additional, Brutti, Julia, additional, Tenorio, Laura, additional, Garavito, Jorge, additional, Zevallos, Katherine, additional, Contreras, Fernando, additional, Infante, Mirtha, additional, Vera-Pozo, Emilia, additional, Tagle, Martín, additional, Toro, Luis G, additional, Rocha, Carlos A De La, additional, Simian, Daniela, additional, and Silva, Marcelo O, additional

Published
2023
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15. P- 34 HEPATOCELLULAR CARCINOMA IN CHILE; A RETROSPECTIVE MULTICENTER STUDY OF 856 PATIENTS

Author

Norero, Blanca, primary, Latorre, Gonzalo, additional, Reyes, Diego, additional, Benitez, Carlos, additional, Wolff, Rodrigo, additional, Arrese, Marco, additional, Morales, Macarena Viñuela, additional, Parada, Matias Torres, additional, Mezzano, Gabriel, additional, Aguirre, Herman, additional, Busquets, Javiera, additional, Martinez, Edmundo, additional, Tapia, Maria Elisa, additional, Mendoza, Natalia, additional, Pavez, Claudia, additional, Ginesta, Alexandra, additional, Gomez, Fernando, additional, Contreras, Jorge, additional, Sanhueza, Edgar, additional, Rius, Monserrat, additional, Jimenez, Andrea, additional, Castro, Lorena, additional, Brahm, Javier, additional, Silva, Guillemo, additional, Urzua, Alvaro, additional, Poniachick, Jaime, additional, Contreras, Edith, additional, Leiva, José Miguel, additional, Aravena, Edmundo, additional, Larrain, Macarena, additional, Lama, Nicolás, additional, Barajas, Olga, additional, Ferrada, Alejandro, additional, Herman, Pauline, additional, Yaquich, Pamela, additional, Lazarte, Raúl, additional, and Zapata, Rodrigo, additional

Published
2023
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16. P-13 PREVALENCE, CHARACTERIZATION, AND SURVIVAL OF ACUTE ON CHRONIC LIVER FAILURE IN A LATIN AMERICAN COHORT: A MULTICENTER STUDY

Author

Idalsoaga, Francisco, primary, Díaz, Luis Antonio, additional, Ayares, Gustavo, additional, Arnold, Jorge, additional, Meza, Víctor, additional, Manzur, Franco, additional, Sotomayor, Joaquín, additional, Rodríguez, Hernán, additional, Chianale, Franco, additional, Villagrán, Sofía, additional, Schalper, Maximilano, additional, Villafranca, Pablo, additional, Veliz, Maria Jesus, additional, Uribe, Paz, additional, Puebla, Maximiliano, additional, Bustamante, Pablo, additional, Aguirre, Herman, additional, Busquets, Javiera, additional, Mezzano, Gabriel, additional, Roblero, Juan Pablo, additional, and Arab, Juan Pablo, additional

Published
2023
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18. Implementation of a re‐linkage to care strategy in patients with chronic hepatitis C who were lost to follow‐up in Latin America

Author

Mendizabal, Manuel, primary, Thompson, Marcos, additional, Gonzalez‐Ballerga, Esteban, additional, Anders, Margarita, additional, Castro‐Narro, Graciela E., additional, Pessoa, Mario G., additional, Cheinquer, Hugo, additional, Mezzano, Gabriel, additional, Palazzo, Ana, additional, Ridruejo, Ezequiel, additional, Descalzi, Valeria, additional, Velarde‐Ruiz Velasco, Jose A., additional, Marciano, Sebastian, additional, Muñoz, Linda, additional, Schinoni, Maria I., additional, Poniachik, Jaime, additional, Perazzo, Rosalía, additional, Cerda, Eira, additional, Fuster, Francisco, additional, Varon, Adriana, additional, Ruiz García, Sandro, additional, Soza, Alejandro, additional, Cabrera, Cecilia, additional, Gomez‐Aldana, Andres J., additional, Beltrán, Flor de María, additional, Gerona, Solange, additional, Cocozzella, Daniel, additional, Bessone, Fernando, additional, Hernández, Nelia, additional, Alonso, Cristina, additional, Ferreiro, Melina, additional, Antinucci, Florencia, additional, Torre, Aldo, additional, Moutinho, Bruna D., additional, Coelho Borges, Silvia, additional, Gomez, Fernando, additional, Murga, Maria Dolores, additional, Piñero, Federico, additional, Sotera, Gisela F., additional, Ocampo, Jhonier A., additional, Cortés Mollinedo, Valeria A., additional, Simian, Daniela, additional, and Silva, Marcelo O., additional

Published
2022
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19. PD-1/PD-L1 pathway is related to infection development and early mortality in patients with cirrhosis

Author

Juanola, Adria, primary, Pose, Elisa, additional, Blaya, Delia, additional, Solé, Cristina, additional, Mezzano, Gabriel, additional, Jimenez-Esquivel, Natalia, additional, Castillo, Joaquin Andrés, additional, Ribera, Jordi, additional, Portoles, Irene, additional, Perez, Martina, additional, Ma, Ann, additional, Napoleone, Laura, additional, Rubio, Ana Belén, additional, Cervera, Marta, additional, Carol, Marta, additional, Bassegoda, Octavi, additional, Gratacós-Gines, Jordi, additional, Soria, Anna, additional, Fabrellas, Núria, additional, Morales-Ruiz, Manuel, additional, Coll, Mar, additional, Graupera, Isabel, additional, Crespo, Gonzalo, additional, Solà, Elsa, additional, and Ginès, Pere, additional

Published
2022
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23. Implementation of a re‐linkage to care strategy in patients with chronic hepatitis C who were lost to follow‐up in Latin America.

Author

Mendizabal, Manuel, Thompson, Marcos, Gonzalez‐Ballerga, Esteban, Anders, Margarita, Castro‐Narro, Graciela E., Pessoa, Mario G., Cheinquer, Hugo, Mezzano, Gabriel, Palazzo, Ana, Ridruejo, Ezequiel, Descalzi, Valeria, Velarde‐Ruiz Velasco, Jose A., Marciano, Sebastian, Muñoz, Linda, Schinoni, Maria I., Poniachik, Jaime, Perazzo, Rosalía, Cerda, Eira, Fuster, Francisco, and Varon, Adriana

Subjects
CHRONIC hepatitis C, HEPATITIS C virus, NOSOLOGY
Abstract

To achieve WHO's goal of eliminating hepatitis C virus (HCV), innovative strategies must be designed to diagnose and treat more patients. Therefore, we aimed to describe an implementation strategy to identify patients with HCV who were lost to follow‐up (LTFU) and offer them re‐linkage to HCV care. We conducted an implementation study utilizing a strategy to contact patients with HCV who were not under regular follow‐up in 13 countries from Latin America. Patients with HCV were identified by the international classification of diseases (ICD‐9/10) or equivalent. Medical records were then reviewed to confirm the diagnosis of chronic HCV infection defined by anti‐HCV+ and detectable HCV‐RNA. Identified patients who were not under follow‐up by a liver specialist were contacted by telephone or email, and offered a medical reevaluation. A total of 10,364 patients were classified to have HCV. After reviewing their medical charts, 1349 (13%) had undetectable HCV‐RNA or were wrongly coded. Overall, 9015 (86.9%) individuals were identified with chronic HCV infection. A total of 5096 (56.5%) patients were under routine HCV care and 3919 (43.5%) had been LTFU. We were able to contact 1617 (41.3%) of the 3919 patients who were LTFU at the primary medical institution, of which 427 (26.4%) were cured at a different institutions or were dead. Of the remaining patients, 906 (76.1%) were candidates for retrieval. In our cohort, about one out of four patients with chronic HCV who were LTFU were candidates to receive treatment. This strategy has the potential to be effective, accessible and significantly impacts on the HCV care cascade. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Drug-Induced Liver Injury Used in the Treatment of Inflammatory Bowel Disease.

Author

F, Paulina Núñez, Quera, Rodrigo, Bay, Constanza, Castro, Fabiola, and Mezzano, Gabriel

Abstract

Therapeutic options for the management of inflammatory bowel disease [IBD] have been expanding in recent decades. New biological and small molecule therapies have been incorporated into the pharmacological arsenal, allowing a more personalized management, and seeking increasingly strict remission goals. However, the fear of developing adverse events represents one of the most important limitations in deciding its use by patients and by a multidisciplinary team. Despite the risk of hepatotoxicity of thiopurines and methotrexate, these drugs are still used either as monotherapy or as combined therapy with anti-tumour necrosis factor [anti-TNF] biological agents. Although drug-induced liver injury [DILI] appears to be less frequent with anti-TNF agents, newer biologics and small molecules, liver tests should be considered in the follow-up of these patients, especially regarding future combined therapy of biologics or of these drugs with small molecules. The objective of this review is to show data on the risk of developing DILI in patients with IBD who are undergoing treatment with traditional therapy or new drugs, whether biological or small molecules. [ABSTRACT FROM AUTHOR]

Published
2022
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29. FRI-151 - Strategies to eliminate hepatitis C virus infection in the Americas

Author

Diaz, Luis Antonio, García, Sergio, Khan, Rayan, Ayares, Gustavo, Monasterio, Javier Uribe, Idalsoaga, Francisco, Fuentes, Eduardo, Medel, María Paz, Ramirez, Carolina, Lazo, Mariana, Ferreccio, Catterina, Mendizabal, Manuel, Dirchwolf, Melisa, Guerra, Patricia, Oliveira, Claudia, Pessoa, Mário, Álvares-da-Silva, Mario, Sebastiani, Giada, Brahmania, Mayur, Ramji, Alnoor, Niazi, Mina, Ko, Hin HIn, Feld, Jordan J., Restrepo, Juan Carlos, Ramirez, Wagner, Alfaro, Omar, Castellanos-Fernández, Marlen, Carrera, Enrique, Aguirre, Jose Roberto, Maldonado Cardona, Katherine Emilia, Sanchez, Abel, Sánchez, Marco, Andara, Maria Teresa, Castro-Narro, Graciela, Chávez-Tapia, Norberto Carlos, Méndez-Sánchez, Nahum, Adames, Enrique, Lombardo, Julissa, Girala, Marcos, Morán, Elias, Padilla, P. Martin, Diaz-Ferrer, Javier, Tagle, Martin, Mainardi, Victoria, Hernandez, Nélia, Martinez, Edmundo, Alvarado-Tapias, Edilmar, Robert, Leon, Hernandez-Tejero, Maria, De Sicilia, Mauricio Garcia Saenz, Zhang, Wei, Bajaj, Jasmohan S., Tapper, Elliot, Izzy, Manhal, Gish, Robert G., Attar, Bashar, Cotter, Thomas, Kamath, Patrick S., Singal, Ashwani, Bataller, Ramon, Mezzano, Gabriel, Soza, Alejandro, Lazarus, Jeffrey, Arrese, Marco, and Arab, Juan Pablo

Published
2023
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30. WED-343 - Serum PDL1 levels are associated with increased risk of bacterial infections in non-hospitalised patients with cirrhosis

Author

Juanola, Adria, Mezzano, Gabriel, Incicco, Simone, Pose, Elisa, Blaya, Delia, Solé, Cristina, Jimenez-Esquivel, Natalia, Castillo, Joaquin Andrés, Ribera, Jordi, Almodovar, Xènia, Perez, Martina, Rubio Garcia, Ana Belen, Cervera, Marta, Carol, Marta, Nadal, Ruth, Arslanow, Anita, Gratacos, Jordi, Soria, Anna, Fabrellas, Núria, Angeli, Paolo, Morales-Ruiz, Manuel, Coll, Mar, Graupera, Isabel, Piano, Salvatore, Solà, Elsa, and Ginès, Pere

Published
2023
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33. Syphilitic hepatitis. Report of three cases

Author

Mezzano, Gabriel, Rondón, Francisco, Cid, Allyson, Parra, Felipe, Soto, Andrés, Gómez, Fernando, Jara, Daniela, and Jirón, María Isabel

Subjects
Sexually Transmitted Diseases, Syphilis, digestive system diseases, Hepatitis
Abstract

Liver involvement occurs in 0.2 to 3% of patients with syphilis. We report three patients with liver involvement in syphilis. A 52-year-old male presenting with erythema and malaise. Laboratory showed a gamma glutamyl transpeptidase (GGT) of 853 u/l, alkaline phosphatases of 1,010 U/L and VDRL was positive. Treatment with penicillin resolved the skin problem and normalized liver enzymes. A HIV positive 30-year-old male in peritoneal dialysis presenting with itching, malaise and markedly elevated GGT and alkaline phosphatases. VDRL was positive. He was treated with penicillin with remission of symptoms and enzyme normalization. A 43-year-old male presenting with erythema, malaise, arthralgias and elevated GGT and alkaline phosphatases. VDRL was positive and treatment with penicillin reverted symptoms and laboratory abnormalities.

Published
2019

34. Frailty and reduced gait speed are independently related to mortality of cirrhotic patients in long-term follow-up.

Author

Sotoa, Rubén, Díaz, Luis Antonio, Rivas, Violeta, Fuentes-López, Eduardo, Zalaquett, Macarena, José Bruera, María, González, Cecilia, Mezzano, Gabriel, and Benítez, Carlos

Subjects
WALKING speed, FRAILTY, GAIT in humans, BIOMARKERS, MORTALITY
Abstract

Introduction and objectives: Frailty is characterized by a poor restoration of homeostasis after a stressor event. Although it is not usually diagnosed, it has been associated with decreased survival in cirrhotic patients. We aimed to evaluate the impact of frailty and decreased gait speed over survival in cirrhotic patients at long-term follow-up. Materials and methods: We included stable cirrhotic patients Child-Pugh B-C or MELD =12, =50 years old. We performed a clinical evaluation, anthropometry, and laboratory tests. Frailty was diagnosed using Fried Frailty Index. We evaluated survival at a 4-year follow-up. Results: We included 126 patients; mean age 64 ± 8.3 years, median MELD-Na 15[12-17], median followup was 881 [349-1277] days. The main etiology was MAFLD (31.4%). Frailty was diagnosed in 65.1% of patients. There were no significant differences in baseline characteristics per frailty condition. Mortality was higher in frail patients than non-frail patients (68.2% versus 20.6% at 48 months, respectively; p-value <0.001). The mean gait speed in frail and non-frail patients was 0.86 ± 0.3 m/s and 1.16 ± 0.2 m/s, respectively (p-value <0.001). Interestingly, 26.9% of patients presented a reduced gait speed (=0.8 m/s). Patients with decreased gait speed also had higher mortality than patients with normal gait speed (79.9% versus 40.8%, respectively; p-value <0.001). A multivariate-adjusted model showed that decreased gait speed (HR = 3.27, 95%CI:1.74-6.14; p < 0.001) and frailty (HR = 4.24, 95%CI:1.89-9.51; p < 0.001) were associated with mortality. Conclusions: Frailty is independently associated with decreased survival at long-term follow-up. Reduced gait speed is strongly associated with mortality and could be a surrogate marker of frailty in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2021
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35. SAT532 - PD-1/PD-L1 pathway is related to infection development and early mortality in patients with cirrhosis

Author

Juanola, Adria, Pose, Elisa, Blaya, Delia, Solé, Cristina, Mezzano, Gabriel, Jimenez-Esquivel, Natalia, Castillo, Joaquin Andrés, Ribera, Jordi, Portoles, Irene, Perez, Martina, Ma, Ann, Napoleone, Laura, Rubio, Ana Belén, Cervera, Marta, Carol, Marta, Bassegoda, Octavi, Gratacós-Gines, Jordi, Soria, Anna, Fabrellas, Núria, Morales-Ruiz, Manuel, Coll, Mar, Graupera, Isabel, Crespo, Gonzalo, Solà, Elsa, and Ginès, Pere

Published
2022
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36. SAT-046-Clinical impact of rectal colonization by multidrug-resistant bacteria in patients with decompensated cirrhosis

Author

Hernandez-Tejero, Maria, primary, Reverte, Francesc Marco, additional, Aziz, Fatima, additional, Pitart, Cristina, additional, Campo, Irene, additional, Carpio, Adrià, additional, López-Suñé, Ester, additional, Ortiz, Santiago, additional, Mezzano, Gabriel, additional, Ginès, Pere, additional, Soriano, Alex, additional, Vila, Jordi, additional, and Fernandez, Javier, additional

Published
2019
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37. THU-047-Recalbration of the CLIF-C ACLF score after weighting by organ and by the presence of TIPS in patients with acute-on-chronic liver failure

Author

Reverter, Enric, primary, Carpio, Adrià, additional, Olivas, Pol, additional, Juanola, Adria, additional, Jung, Gerhard, additional, Mezzano, Gabriel, additional, Botana, Karina, additional, Santillán, Julieta, additional, Hernandez-Tejero, Maria, additional, Aziz, Fatima, additional, Escorsell, Angels, additional, and Fernandez, Javier, additional

Published
2019
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38. FRI-434-Role of next generation sequencing in the etiological diagnosis of splanchnic venous thrombosis

Author

Magaz, Marta, primary, Álvarez-Larrán, Alberto, additional, Colomer, Dolors, additional, López, Mónica, additional, Mezzano, Gabriel, additional, Turon, Fanny, additional, Baiges, Anna, additional, Ferrusquia, José, additional, Ble, Michel, additional, Orts, Lara, additional, Berbel, Claudia, additional, Cervantes, Francisco, additional, Hernandez-Gea, Virginia, additional, and Garcia-Pagan, Juan-Carlos, additional

Published
2019
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39. SAT-045-Prevalence, type and risk factors of colonization by multidrug-resistant bacteria in a large series of patients with decompensated cirrhosis

Author

Hernandez-Tejero, Maria, primary, Aziz, Fatima, additional, Pitart, Cristina, additional, Reverte, Francesc Marco, additional, Campo, Irene, additional, Carpio, Adrià, additional, Reverter, Enric, additional, Escorsell, Angels, additional, Ortiz, Santiago, additional, Mezzano, Gabriel, additional, Ginès, Pere, additional, Soriano, Alex, additional, Vila, Jordi, additional, and Fernandez, Javier, additional

Published
2019
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45. Terremoto 2010: Impacto en la incidencia de lesiones subepicárdicas. experiencia en telemedicina

Author

Bello, Francesca, Adriazola, Patricia, Escobar, Edgardo, Pavlov, Stefania, Mezzano, Gabriel, and Lama, Denisse

Subjects
ECG, earthquake, telemedicine
Abstract

La asociación de estrés y eventos coronarios agudos ha sido extensamente estudiada. En relación a un evento estresante existiría un aumento en la liberación de ca-tecolaminas que incide en un incremento en la presión arterial y alteraciones de hemostasia, como sería el caso de un terremoto. En el presente trabajo se describe la relación contemporánea observada entre el terremoto del 27 de febrero del 2010 y el diagnóstico de lesión subepicárdica, en electrocardiogramas recibidos en ITMS, Telemedicina de Chile. Se analizaron 280.592 electrocardiogramas (ECGs) provenientes de todo el territorio nacional, que corresponden a un periodo de 12 meses de los años 2009 y 2010. Se realizó una comparación estadística entre el porcentaje de lesiones subepicárdicas registradas en el fin de semana del terremoto (27/02/2010 y 28/02/2010) versus los fines de semana de los meses estudiados. Se obtuvieron los datos correspondientes a siete pacientes que se encontraban con monitoreo ambulatorio de presión arterial (MAPA) el día 27/02. El diagnóstico de lesión subepicárdica se hizo en 1.795 trazados, correspondientes a un 0.64% del total de ECGs recibidos. Hubo un aumento estadísticamente significativo de las lesiones subepicárdicas (p

Published
2012

49. Hepatitis E virus seroprevalence: a reappraisal

Author

Covarrubias, Natalia, Hurtado, Carmen, Diaz, Alex, Mezzano, Gabriel, Brahm, Javier, and Mauricio Venegas

Subjects
seroprevalence, Hepatitis E Virus, seroprevalencia, IgG antibody, anticuerpos IgG, Virus hepatitis E
Abstract

En los países desarrollados se reportan seroprevalencias de virus hepatitis E (VHE) entre 0,3 y 53%. Los datos publicados están influenciados por las cualidades técnicas de los ensayos utilizados. La sensibilidad de las nuevas pruebas ha mejorado, lo que está cambiando la seroprevalencia del VHE en el mundo. En el presente estudio, reevaluamos en forma retrospectiva 178 muestras de suero de pacientes con estudio previo de anticuerpos IgG anti-VHE entre los años 2009 y 2012. El análisis previo se realizó con ELISA Genelabs (Singapur), siendo 7,3% positivas. La reevaluación fue realizada con ELISA AccuDiagTM HEV-IgG (Diagnostic Automation, E.U.A), el cual reporta una sensibilidad y especificidad de 99,8%. Con este nuevo ensayo, encontramos 32,6% de muestras positivas, resultado significativamente mayor al resultado previo (p < 0,001) (incremento de 4,5 veces). No hubo diferencias en género y se encontró una asociación significativa entre la edad y la seropositividad para IgG anti-VHE (p < 0,001). Estos resultados sugieren que los estudios previos pueden haber subestimado la seroprevalencia de VHE en Chile, la que debe ser reevaluada con los nuevos ensayos disponibles. Reported seroprevalence of hepatitis E virus (HEV) in developed countries is between 0.3-53%. Published data relies on the assays used and its technical performance. Sensitivity on new available tests has improved, which has changed HEV seroprevalence around the world. We re-evaluated retrospectively, 178 serum samples of patients with previous anti HEV IgG determination between 2009 and 2012. Initial analysis was performed with ELISA kit Genelabs (Singapore), with 7.3% positivity. The reevaluation was done with ELISA kit AccuDiag TM HEV-IgG (Diagnostic Automation, United States), with reported sensitivity and specificity over 99.8%. With the new assay, 32.6% positive samples were found, significantly greater to the previous result (p < 0.001) (4.5 times more). There were no differences in gender but a significant association between age and HEV IgG seropositivity was found (p < 0.001). This suggests that previous testing might have underestimated HEV seroprevalence in Chile, which should be reevaluated using the new available test.

50. Casual finding in colonoscopy: Diphyllobothrium latum.

Author

Pérez-Valenzuela J, Aguirre H, and Mezzano G

Abstract

Diphyllobothrium spp., also known as fish tapeworms, is the largest human tapeworm, reaching up to 25 meters of length. Human are considered the definitive host in the Diphyllobothrium lifecycle. Adult tapeworms attach to human intestinal mucosa with to bilateral grooves. There are at least 14 different species of Diphyllobothrium spp. Capable of causing Dyphyllobothriosis, being D. latum and D. nihonkaiense the most frequent etiologic agents in humans. We present the clinical picture and endoscopic images on a patient with incidental finding of Dyphyllobothriosis in a colonoscopy.

Published
2024
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