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Your search keyword '"Mezhuev, Yaroslav O."' showing total 29 results
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29 results on '"Mezhuev, Yaroslav O."'

3. Kinetics of Methyl Methacrylate Polymerization in the Presence of Initiating Systems "Peroxide + Zirconocene Dichloride" When the Methyl Methacrylate Adhesive is Cured.

Author

Tereshchenko, Konstantin A., Shiyan, Daria A., Osipov, Andrey A., Bondarenko, Vera P., Ulitin, Nikolai V., Sabitova, Elina M., Bekker, Anton V., Lyulinskaya, Yana L., Novikov, Nikolay A., Nurullina, Natalia M., Tuntseva, Svetlana N., Puchkova, Tatyana L., Mezhuev, Yaroslav O., Kharlampidi, Kharlampii E., and Kolesov, Sergey V.

Published
2024
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4. Numerical Simulation of Hydrodynamics and Heat Transfer in a Reactor with a Fluidized Bed of Catalyst Particles in a Three-Dimensional Formulation.

Author

Ulitin, Nikolai V., Tereshchenko, Konstantin A., Rodionov, Ilya S., Alekseev, Konstantin A., Shiyan, Daria A., Kharlampidi, Kharlampii E., and Mezhuev, Yaroslav O.

Subjects
FLUIDIZED bed reactors, HEAT transfer, DISCRETE element method, HYDRODYNAMICS, COMPUTER simulation
Abstract

The hydrodynamics and heat transfer in a reactor with a fluidized bed of catalyst particles and an inert material were simulated. The particle bed (the particle density was 2350 kg/m3, and the particle diameter was 1.5 to 4 mm) was located in a distribution device which was a grid of 90 × 90 × 60 mm vertical baffles. The behavior of the liquefying medium (air) was modeled using a realizable k-ε turbulence model. The behavior of particles was modeled using the discrete element method (DEM). In order to reduce the slugging effect, the particles were divided into four separate horizontal layers. It was determined that with the velocity of the liquefying medium close to the minimum fluidization velocity (1 m/s), slugging fluidization is observed. At a velocity of the liquefying medium of 3 m/s, turbulent fluidization in the lowest particle layer and bubbling fluidization on subsequent particle layers are observed. With an increase in the velocity of the liquefying medium over 3 m/s, entrainment of particles is observed. It was shown that a decrease in the density of the liquefying medium from 1.205 kg/m3 to 0.383 kg/m3 when it is heated from 298 K to 923 K would not significantly affect the hydraulic resistance of the bed. Based on the obtained results, it can be stated that the obtained model is optimal for such problems and is suitable for the further description of experimental data. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Hydrophilization and Functionalization of Fullerene C 60 with Maleic Acid Copolymers by Forming a Non-Covalent Complex.

Author

Samoilova, Nadezhda A., Krayukhina, Maria A., Klemenkova, Zinaida S., Naumkin, Alexander V., Buzin, Michail I., Mezhuev, Yaroslav O., Turetsky, Evgeniy A., Andreev, Sergey M., Anuchina, Nelya M., and Popov, Dmitry A.

Subjects
MALEIC acid, COPOLYMERS, ULTRAVIOLET-visible spectroscopy, WATER use, AQUEOUS solutions, CONJUGATED polymers, FULLERENE polymers, FULLERENES
Abstract

In this study, we report an easy approach for the production of aqueous dispersions of C60 fullerene with good stability. Maleic acid copolymers, poly(styrene-alt-maleic acid) (SM), poly(N-vinyl-2-pyrrolidone-alt-maleic acid) (VM) and poly(ethylene-alt-maleic acid) (EM) were used to stabilize C60 fullerene molecules in an aqueous environment by forming non-covalent complexes. Polymer conjugates were prepared by mixing a solution of fullerene in N-methylpyrrolidone (NMP) with an aqueous solution of the copolymer, followed by exhaustive dialysis against water. The molar ratios of maleic acid residues in the copolymer and C60 were 5/1 for SM and VM and 10/1 for EM. The volume ratio of NMP and water used was 1:1.2–1.6. Water-soluble complexes (composites) dried lyophilically retained solubility in NMP and water but were practically insoluble in non-polar solvents. The optical and physical properties of the preparations were characterized by UV-Vis spectroscopy, FTIR, DLS, TGA and XPS. The average diameter of the composites in water was 120–200 nm, and the ξ-potential ranged from −16 to −20 mV. The bactericidal properties of the obtained nanostructures were studied. Toxic reagents and time-consuming procedures were not used in the preparation of water-soluble C60 nanocomposites stabilized by the proposed copolymers. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Gel Based on Hydroxyethyl Starch with Immobilized Amikacin for Coating of Bone Matrices in Experimental Osteomyelitis Treatment

Author

Luss, Anna, primary, Kushnerev, Kirill, additional, Vlaskina, Elizaveta, additional, Vanyushenkova, Anna, additional, Mezhuev, Yaroslav O., additional, Krivoborodov, Efrem, additional, Toropygin, Ilya, additional, Gavryushenko, Nikolai, additional, Vetrile, Marchel, additional, Zaitsev, Vladimir, additional, and Dyatlov, Valerie, additional

Published
2023
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11. The Effect of Metals of the 2nd and 12th Groups on the Productivity and Selectivity of Cumene Oxidation—The First Stage of the Technological Chain for the Production of Polymer Composites

Author

Ulitin, Nikolai V., primary, Shiyan, Daria A., additional, Lyulinskaya, Yana L., additional, Novikov, Nikolay A., additional, Tereshchenko, Konstantin A., additional, Nurullina, Natalia M., additional, Denisova, Marina N., additional, Kharlampidi, Kharlampii E., additional, and Mezhuev, Yaroslav O., additional

Published
2023
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12. The Effect of Ca, Sr, and Ba Chloride Complexes with Dibenzo-18-Crown-6 Ether as Catalysts on the Process Criteria for the Efficiency of Cumene Oxidation (the First Stage in the Chain of Polymer Composite Production)

Author

Ulitin, Nikolai V., primary, Novikov, Nikolay A., additional, Lyulinskaya, Yana L., additional, Shiyan, Daria A., additional, Tereshchenko, Konstantin A., additional, Nurullina, Natalia M., additional, Denisova, Marina N., additional, Mezhuev, Yaroslav O., additional, and Kharlampidi, Kharlampii E., additional

Published
2023
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13. Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

Author

Artyukhov, Alexander A., primary, Nechaeva, Anna M., additional, Shtilman, Mikhail I., additional, Chistyakov, Evgeniy M., additional, Svistunova, Alina Yu., additional, Bagrov, Dmitry V., additional, Kuskov, Andrey N., additional, Docea, Anca O., additional, Tsatsakis, Aristides M., additional, Gurevich, Leonid, additional, and Mezhuev, Yaroslav O., additional

Published
2022
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14. Promising Gene Delivery Properties of Polycations Based on 2-(N, N -dimethylamino)ethyl Methacrylate and Polyethylene Glycol Monomethyl Ether Methacrylate Copolymers.

Author

Loginova, Tatiana P., Khotina, Irina A., Kabachii, Yurii A., Kochev, Sergei Yu., Abramov, Vyacheslav M., Khlebnikov, Valentin S., Kulikova, Natalia L., and Mezhuev, Yaroslav O.

Subjects
POLYETHYLENE glycol, METHACRYLATES, CIRCULAR DNA, ZETA potential, POTENTIOMETRY, GENE transfection
Abstract

Cationic copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and polyethylene glycol monomethyl ether (pDMAEMA-co-PEO) with different molecular weights have been synthesized. Their physicochemical properties were studied by NMR spectroscopy, sedimentation, and potentiometric titration. According to the data of potentiometric titration for the synthesized pegylated cationic copolymers, the apparent dissociation constants were determined in the pH range from 4.5 to 8.5. The physicochemical properties of interpolyelectrolyte complexes of these polycations with circular DNA (IPEC DNA) were also studied by dynamic light scattering, electrophoretic mobility, and TEM methods. It has been established that the diameter and electrokinetic potential (ζ-potential) of interpolyelectrolyte complexes can be varied over a wide range (from 200 nm to 1.5 μm and from −25 mV to +30 mV) by changing the ratio of oppositely charged ionizable groups in pegylated cationic copolymers and DNA, as well as by regulating medium pH. The resistance of the IPEC DNA/polycation complex to the action of nucleases was studied by electrophoresis in agarose gel; the cytotoxic effect of the polymers in vitro, and the efficiency of penetration (transfection) of IPEC DNA with PDMAEMA-co-PEO-polycations into eukaryotic cells of a cell line derived from human embryonic kidneys HEK 293 in vitro. [ABSTRACT FROM AUTHOR]

Published
2023
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16. The Synthesis and Properties of a New Carrier for Paclitaxel and Doxorubicin Based on the Amphiphilic Copolymer of N ‐vinyl‐2‐pyrrolidone and Acrylic Acid

Author

Nechaeva, Anna M., primary, Artyukhov, Alexander A., additional, Luss, Anna L., additional, Shtilman, Mikhail I., additional, Svistunova, Alina Yu., additional, Motyakin, Mikhail V., additional, Levina, Irina I., additional, Krivoborodov, Efrem G., additional, Toropygin, Ilya Yu., additional, Chistyakov, Evgeniy M., additional, Tsatsakis, Aristides M., additional, Gurevich, Leonid, additional, and Mezhuev, Yaroslav O., additional

Published
2022
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17. Hybrid (Bovine Serum Albumin)/Poly(N-vinyl-2-pyrrolidone-co-acrylic acid)-Shelled Microbubbles as Advanced Ultrasound Contrast Agents

Author

Estifeeva, Tatyana M., primary, Barmin, Roman A., additional, Rudakovskaya, Polina G., additional, Nechaeva, Anna M., additional, Luss, Anna L., additional, Mezhuev, Yaroslav O., additional, Chernyshev, Vasiliy S., additional, Krivoborodov, Efrem G., additional, Klimenko, Oleg A., additional, Sindeeva, Olga A., additional, Demina, Polina A., additional, Petrov, Kirill S., additional, Chuprov-Netochin, Roman N., additional, Fedotkina, Elena P., additional, Korotchenko, Olga E., additional, Sencha, Ekaterina A., additional, Sencha, Alexander N., additional, Shtilman, Mikhail I., additional, and Gorin, Dmitry A., additional

Published
2022
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19. Synthesis, Self-Assembly and In Vitro Cellular Uptake Kinetics of Nanosized Drug Carriers Based on Aggregates of Amphiphilic Oligomers of N-Vinyl-2-pyrrolidone

Author

Kulikov, Pavel P., primary, Luss, Anna L., additional, Nelemans, Levi C., additional, Shtilman, Mikhail I., additional, Mezhuev, Yaroslav O., additional, Kuznetsov, Igor A., additional, Sizova, Oksana Yu., additional, Christiansen, Gunna, additional, Pennisi, Cristian P., additional, and Gurevich, Leonid, additional

Published
2021
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21. Chemical Oxidative Polymerization of Methylene Blue: Reaction Mechanism and Aspects of Chain Structure

Author

Mezhuev, Yaroslav O., primary, Vorobev, Igor Y., additional, Plyushchii, Ivan V., additional, Krivoborodov, Efrem G., additional, Artyukhov, Alexander A., additional, Motyakin, Mikhail V., additional, Luss, Anna L., additional, Ionova, Irina S., additional, Kovarskii, Alexander L., additional, Derevnin, Igor A., additional, Dyatlov, Valerie A., additional, Alekperov, Ruslan A., additional, Toropygin, Ilya Y., additional, Volkov, Mikhail A., additional, Shtilman, Mikhail I., additional, and Korshak, Yuri V., additional

Published
2021
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27. Nanosized carriers based on amphiphilic poly-N-vinyl-2-pyrrolidone for intranuclear drug delivery

Author

Luss, Anna L, primary, Kulikov, Pavel P, additional, Romme, Sven B, additional, Andersen, Camilla L, additional, Pennisi, Cristian P, additional, Docea, Anca O, additional, Kuskov, Andrey N, additional, Velonia, Kelly, additional, Mezhuev, Yaroslav O, additional, Shtilman, Mikhail I, additional, Tsatsakis, Aristidis M, additional, and Gurevich, Leonid, additional

Published
2018
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28. Oxidative polymerization of aromatic amines: kinetic features and possible mechanisms

Author

Mezhuev, Yaroslav O., Korshak, Yuri V., and Shtilman, Mikhail I.

Abstract

The state-of-the-art studies into the synthesis of electrically conducting polymers by oxidative polymerization of aromatic amines are surveyed. The attention is focused on polyaniline, the most important representative of this class of polymers. The concepts of possible mechanisms, types of active sites and kinetic features of the oxidative polymerization of aromatic amines are analyzed and integrated. Considerable attention is paid to the formation of the new phase having a catalytic action. Numerous effects reported in the literature are explained in terms of the views on oxidative polymerization of aromatic amines as a heterogeneous autocatalytic process.The bibliography includes 153 references.

Published
2017

29. Hybrid (Bovine Serum Albumin)/Poly( N -vinyl-2-pyrrolidone- co -acrylic acid)-Shelled Microbubbles as Advanced Ultrasound Contrast Agents.

Author

Estifeeva TM, Barmin RA, Rudakovskaya PG, Nechaeva AM, Luss AL, Mezhuev YO, Chernyshev VS, Krivoborodov EG, Klimenko OA, Sindeeva OA, Demina PA, Petrov KS, Chuprov-Netochin RN, Fedotkina EP, Korotchenko OE, Sencha EA, Sencha AN, Shtilman MI, and Gorin DA

Subjects
Acrylates, Acrylic Resins, Polymers chemistry, Povidone analogs & derivatives, Serum Albumin, Bovine, Contrast Media chemistry, Microbubbles
Abstract

Microbubbles are routinely used ultrasound contrast agents in the clinic. While a soft protein shell is commercially preferable for imaging purposes, a rigid polymer shell demonstrates prolonged agent stability. Hence, combining polymers and proteins in one shell composition can advance microbubble properties. We formulated the hybrid "protein-copolymer" microbubble shell with a complex of bovine serum albumin and an amphiphilic copolymer of N -vinyl-2-pyrrolidone and acrylic acid. The resulting microbubbles demonstrated advanced physicochemical and acoustic properties, preserving in vitro biocompatibility. Adjusting the mass ratio between protein and copolymer allowed fine tuning of the microbubble properties of concentration (by two orders, up to 10 10 MBs/mL), mean size (from 0.8 to 5 μm), and shell thickness (from 28 to 50 nm). In addition, the minimum air-liquid surface tension for the "protein-copolymer" solution enabled the highest bubble concentration. At the same time, a higher copolymer amount in the bubble shell increased the bubble size and tuned duration and intensity of the contrast during an ultrasound procedure. Demonstrated results exemplify the potential of the hybrid "protein-polymer" microbubble shell, allowing tailoring of microbubble properties for image-guided applications, combining advances of each material involved in the formulation.

Published
2022
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