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41 results on '"Mezawa, Masaru"'

3. Utility of a haemoglobin test of gingival crevicular fluid: A multicentre, observational study.

Author

Ito, Hiroshi, Numabe, Yukihiro, Hashimoto, Shuichi, Sekino, Satoshi, Murakashi, Etsuko, Ishiguro, Hitomi, Sasaki, Daisuke, Yaegashi, Takashi, Takai, Hideki, Mezawa, Masaru, Ogata, Yorimasa, Watanabe, Hisashi, Izumi, Yuichi, Kido, Jun‐Ichi, Hiroshima, Yuka, and Nagata, Toshihiko

Subjects
PERIODONTITIS treatment, PROTEIN analysis, PREDICTIVE tests, RESEARCH funding, GINGIVA, HEMOGLOBINS, SCIENTIFIC observation, GINGIVITIS, ASPARTATE aminotransferase, TREATMENT effectiveness, RESEARCH, DENTAL plaque, EXUDATES & transudates, PERIODONTITIS, EVALUATION
Abstract

Objective: The purpose of this study was to verify the accuracy and utility of clinical parameters (plaque index, gingival crevicular fluid volume, probing depth, clinical attachment level, bleeding on probing and gingival index) and biochemical parameters (aspartate aminotransferase, protein and haemoglobin) in a longitudinal analysis during the supportive periodontal therapy period. Subjects and Methods: A total of 279 test sites of 128 patients were investigated clinically and biochemically. After the first examination of clinical and biochemical parameters, periodontal support treatments were administered immediately and performed once every three months up to the second examination. Results: All of the clinical and biochemical parameters were significantly lower at the second examination than at the first, except for the plaque index and bleeding on probing. Of these parameters, in particular, aspartate aminotransferase and haemoglobin in the gingival crevicular fluid were significantly reduced compared to those of the first examination in both the ≤4 and ≥5 mm probing depth groups, and they clearly suggested that periodontitis tended to recover. Conclusion: Adding the haemoglobin test to the bleeding on probing test strongly improves the accuracy of measurement of clinical parameters after periodontal treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Utility of a haemoglobin test of gingival crevicular fluid: A multicentre, observational study

Author

Ito, Hiroshi, primary, Numabe, Yukihiro, additional, Hashimoto, Shuichi, additional, Sekino, Satoshi, additional, Murakashi, Etsuko, additional, Ishiguro, Hitomi, additional, Sasaki, Daisuke, additional, Yaegashi, Takashi, additional, Takai, Hideki, additional, Mezawa, Masaru, additional, Ogata, Yorimasa, additional, Watanabe, Hisashi, additional, Izumi, Yuichi, additional, Kido, Jun‐Ichi, additional, Hiroshima, Yuka, additional, and Nagata, Toshihiko, additional

Published
2023
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10. Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy

Author

Ito, Hiroshi, Numabe, Yukihiro, Sekino, Satoshi, Murakashi, Etsuko, Iguchi, Hitomi, Hashimoto, Shuichi, Sasaki, Daisuke, Yaegashi, Takashi, Kunimatsu, Kazushi, Takai, Hideki, Mezawa, Masaru, Ogata, Yorimasa, Watanabe, Hisashi, Hagiwara, Satsuki, Izumi, Yuichi, Hiroshima, Yuka, Kido, Jun-Ichi, and Nagata, Toshihiko

Published
2014
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11. A multicenter prospective cohort study on the effect of smoking cessation on periodontal therapies in Japan

Author

Nakayama, Yohei, primary, Mizutani, Koji, additional, Tsumanuma, Yuka, additional, Yoshino, Hiroyuki, additional, Aoyama, Norio, additional, Inagaki, Koji, additional, Morita, Manabu, additional, Izumi, Yuichi, additional, Murakami, Shinya, additional, Yoshimura, Hidenori, additional, Matsuura, Takanori, additional, Murakami, Takashi, additional, Yamamoto, Matsuo, additional, Yoshinari, Nobuo, additional, Mezawa, Masaru, additional, Ogata, Yorimasa, additional, Yoshimura, Atsutoshi, additional, Kono, Kanji, additional, Maruyama, Kosuke, additional, Sato, Soh, additional, Sakagami, Ryuji, additional, Ito, Hiroshi, additional, Numabe, Yukihiro, additional, Nikaido, Masahiko, additional, Hanioka, Takashi, additional, Seto, Kanichi, additional, Fukuda, Jinichi, additional, Warnakulasuriya, Saman, additional, and Nagao, Toru, additional

Published
2021
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14. Erratum to: Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy

Author

Ito, Hiroshi, Numabe, Yukihiro, Sekino, Satoshi, Murakashi, Etsuko, Iguchi, Hitomi, Hashimoto, Shuichi, Sasaki, Daisuke, Yaegashi, Takashi, Kunimatsu, Kazushi, Takai, Hideki, Mezawa, Masaru, Ogata, Yorimasa, Watanabe, Hisashi, Hagiwara, Satsuki, Izumi, Yuichi, Hiroshima, Yuka, Kido, Jun-Ichi, and Nagata, Toshihiko

Published
2014
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15. Impact of adjunctive procedures on recombinant human fibroblast growth factor-2-mediated periodontal regeneration therapy: A retrospective study.

Author

Nakayama, Yohei, Matsuda, Hideo, Itoh, Shoichi, Iwai, Yasunobu, Takai, Hideki, Mezawa, Masaru, Yoshino, Shoichi, and Ogata, Yorimasa

Abstract

Background: Human fibroblast growth factor-2 (rhFGF-2) therapy has been used for periodontal tissue regeneration. However, few studies have reported their adjunctive procedures based on strategy of tissue engineering. The aim of this retrospective study is to assess the adjunctive effects of modified papilla preservation technique (mPPT) and combination with autogenous bone grafts (AG) on the rhFGF-2 therapy.Methods: Total of 44 sites underwent rhFGF-2 therapies and the evaluations in the survey periods. The primary outcome was set to the radiographic bone fill by radiographic examinations at 6 and 12 months after surgeries. We analyzed the correlation between influencing factors and the primary outcome, and differences of therapeutic effect by combination therapy with mPPT and that with AG.Results: After surgeries, probing depth (PD), clinical attachment level (CAL) and bone defects significantly improved. The improvements of radiographic bone fill were significantly positive correlated with a number of bone walls, combination with mPPT, and AG at 6 months after surgeries, and with combination with mPPT and AG at 12 months after surgeries. The significant differences of improvements of radiographic bone fill were demonstrated between combination with or without mPPT at 12 months after surgeries, and with or without AG at 6 and 12 months after surgeries. Moreover, the multiple linear regression analysis for the radiographic bone fill indicated the significant regression coefficient with conducts of mPPT.Conclusions: mPPT and AG had powerfully adjunctive effects on rhFGF-2 therapy. Further studies are needed in order to verify by randomized clinical trials. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Correlation Between Gingival Crevicular Fluid Hemoglobin Content and Periodontal Clinical Parameters

Author

Ito, Hiroshi, primary, Numabe, Yukihiro, additional, Hashimoto, Shuichi, additional, Sekino, Satoshi, additional, Murakashi, Etsuko, additional, Ishiguro, Hitomi, additional, Sasaki, Daisuke, additional, Yaegashi, Takashi, additional, Takai, Hideki, additional, Mezawa, Masaru, additional, Ogata, Yorimasa, additional, Watanabe, Hisashi, additional, Hagiwara, Satsuki, additional, Izumi, Yuichi, additional, Hiroshima, Yuka, additional, Kido, Jun-Ichi, additional, Nagata, Toshihiko, additional, and Kunimatsu, Kazushi, additional

Published
2016
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24. Erratum to: Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy

Author

Ito, Hiroshi, primary, Numabe, Yukihiro, additional, Sekino, Satoshi, additional, Murakashi, Etsuko, additional, Iguchi, Hitomi, additional, Hashimoto, Shuichi, additional, Sasaki, Daisuke, additional, Yaegashi, Takashi, additional, Kunimatsu, Kazushi, additional, Takai, Hideki, additional, Mezawa, Masaru, additional, Ogata, Yorimasa, additional, Watanabe, Hisashi, additional, Hagiwara, Satsuki, additional, Izumi, Yuichi, additional, Hiroshima, Yuka, additional, Kido, Jun-Ichi, additional, and Nagata, Toshihiko, additional

Published
2013
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26. Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy

Author

Ito, Hiroshi, primary, Numabe, Yukihiro, additional, Sekino, Satoshi, additional, Murakashi, Etsuko, additional, Iguchi, Hitomi, additional, Hashimoto, Shuichi, additional, Sasaki, Daisuke, additional, Yaegashi, Takashi, additional, Kunimatsu, Kazushi, additional, Takai, Hideki, additional, Mezawa, Masaru, additional, Ogata, Yorimasa, additional, Watanabe, Hisashi, additional, Hagiwara, Satsuki, additional, Izumi, Yuichi, additional, Hiroshima, Yuka, additional, Kido, Jun-Ichi, additional, and Nagata, Toshihiko, additional

Published
2012
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27. Aggregatibacter actinomycetemcomitans lipopolysaccharide regulates bone sialoprotein gene transcription

Author

Li, Xinyue, primary, Zhou, Liming, additional, Takai, Hideki, additional, Sasaki, Yoko, additional, Mezawa, Masaru, additional, Li, Zhengyang, additional, Wang, Zhitao, additional, Yang, Li, additional, Wang, Shuang, additional, Matsumura, Hiroyoshi, additional, Kaneko, Takashi, additional, Yoshimura, Atsutoshi, additional, and Ogata, Yorimasa, additional

Published
2012
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39. Insulin‐like growth factor‐I increases bone sialoprotein (BSP) expression through fibroblast growth factor‐2 response element and homeodomain protein‐binding site in the proximal promoter of the BSP gene

Author

Nakayama, Youhei, primary, Nakajima, Yu, additional, Kato, Naoko, additional, Takai, Hideki, additional, Kim, Dong‐Soon, additional, Arai, Masato, additional, Mezawa, Masaru, additional, Araki, Shouta, additional, Sodek, Jaro, additional, and Ogata, Yorimasa, additional

Published
2006
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40. Fibroblast growth factor 2 regulates bone sialoprotein gene transcription in human breast cancer cells.

Author

Zhengyang Li, Zhitao Wang, Li Yang, Xinyue Li, Sasaki, Yoko, Shuang Wang, Araki, Shouta, Mezawa, Masaru, Takai, Hideki, Nakayama, Youhei, and Ogata, Yorimasa

Subjects
BREAST cancer research, FIBROBLAST growth factors, MEDICAL transcription, IMMUNOGLOBULINS, DATA analysis, CALCIUM ions, CANCER cells, MITOGENS, LUCIFERASES, PHYSIOLOGY, THERAPEUTICS
Abstract

Bone sialoprotein (BSP) is a major noncollagenous, extracellular matrix glycoprotein associated with mineralized tissues. Fibroblast growth factor 2 (FGF2) is recognized as a potent mitogen for a variety of mesenchymal cells. FGF2 produced by osteoblasts accumulates in the bone matrix and acts as an autocrine/paracrine regulator of osteoblasts. We previously reported that FGF2 regulates BSP gene transcription through the FGF2 response element (FRE) and activator protein 1 (AP1) binding site overlapping with the glucocorticoid response element in the rat BSP gene promoter. In the present study, FGF2 (10 ng/ml) increased BSP and Runx2 mRNA levels at 6 h in MCF7 human breast cancer cells. Transient transfection analyses were performed using chimeric constructs of the human BSP gene promoter linked to a luciferase reporter gene. Treatment of MCF7 cells with FGF2 (10 ng/ml) increased the luciferase activity of the constructs between -84LUC and -927LUC. Gel mobility shift analyses showed that FGF2 increased the binding of AP1 and CRE2. The CRE2- and AP1-protein complexes were disrupted by antibodies against CREB1, c-Fos, c-Jun, Fra2, p300 and Runx2. These studies demonstrate that FGF2 stimulates BSP transcription in MCF7 human breast cancer cells by targeting the AP1 and CRE2 elements in the human BSP gene promoter. [ABSTRACT FROM AUTHOR]

Published
2010
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41. A multicenter prospective cohort study on the effect of smoking cessation on periodontal therapies in Japan.

Author

Nakayama Y, Mizutani K, Tsumanuma Y, Yoshino H, Aoyama N, Inagaki K, Morita M, Izumi Y, Murakami S, Yoshimura H, Matsuura T, Murakami T, Yamamoto M, Yoshinari N, Mezawa M, Ogata Y, Yoshimura A, Kono K, Maruyama K, Sato S, Sakagami R, Ito H, Numabe Y, Nikaido M, Hanioka T, Seto K, Fukuda J, Warnakulasuriya S, and Nagao T

Subjects
Dental Scaling, Humans, Japan, Periodontal Attachment Loss, Periodontal Pocket, Prospective Studies, Root Planing, Smoking, Tobacco Use Cessation Devices, Treatment Outcome, Smoking Cessation
Abstract

Few prospective studies have reported the effects of periodontal therapy on patients who attempted to quit smoking. This study aimed to assess how smoking cessation affects periodontal therapy. Twenty-five smokers with periodontitis were investigated by dividing them into two groups, a smoking cessation support group and a continued smoking group. Those in the support group received counseling and nicotine replacement therapy, followed by periodontal treatment conducted by dentists who had completed an e-learning course on smoking cessation. Clinical parameters were measured at baseline, 3, and 6 months. Most clinical parameters improved for those in the smoking cessation support group. There were no significant improvements in bleeding on probing (BOP) or the number of severe periodontal disease sites in the continued smoking group. Probing pocket depth (PPD) and clinical attachment levels (CAL) at sites that received scaling and root planing (SRP) significantly improved in all subjects. BOP did not improve at reevaluation in the smoking relapse subgroup. Patients in the smoking cessation support program led by dental professionals showed more improvement in BOP than those in the continued smoking group.

Published
2020
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