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1. Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies

Author

Portnoi, Marie-France, Dumargne, Marie-Charlotte, Rojo, Sandra, Witchel, Selma F, Duncan, Andrew J, Eozenou, Caroline, Bignon-Topalovic, Joelle, Yatsenko, Svetlana A, Rajkovic, Aleksandar, Reyes-Mugica, Miguel, Almstrup, Kristian, Fusee, Leila, Srivastava, Yogesh, Chantot-Bastaraud, Sandra, Hyon, Capucine, Louis-Sylvestre, Christine, Validire, Pierre, de Malleray Pichard, Caroline, Ravel, Celia, Christin-Maitre, Sophie, Brauner, Raja, Rossetti, Raffaella, Persani, Luca, Charreau, Eduardo H, Dain, Liliana, Chiauzzi, Violeta A, Mazen, Inas, Rouba, Hassan, Schluth-Bolard, Caroline, MacGowan, Stuart, McLean, WH Irwin, Patin, Etienne, Meyts, Ewa Rajpert-De, Jauch, Ralf, Achermann, John C, Siffroi, Jean-Pierre, McElreavey, Ken, and Bashamboo, Anu

Subjects
Rare Diseases, Contraception/Reproduction, Infertility, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Reproductive health and childbirth, 46, XX Disorders of Sex Development, Adolescent, Child, Disorder of Sex Development, 46, XY, Female, Humans, Male, Mutation, Missense, Oligospermia, Primary Ovarian Insufficiency, SOXE Transcription Factors, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

SOX8 is an HMG-box transcription factor closely related to SRY and SOX9. Deletion of the gene encoding Sox8 in mice causes reproductive dysfunction but the role of SOX8 in humans is unknown. Here, we show that SOX8 is expressed in the somatic cells of the early developing gonad in the human and influences human sex determination. We identified two individuals with 46, XY disorders/differences in sex development (DSD) and chromosomal rearrangements encompassing the SOX8 locus and a third individual with 46, XY DSD and a missense mutation in the HMG-box of SOX8. In vitro functional assays indicate that this mutation alters the biological activity of the protein. As an emerging body of evidence suggests that DSDs and infertility can have common etiologies, we also analysed SOX8 in a cohort of infertile men (n = 274) and two independent cohorts of women with primary ovarian insufficiency (POI; n = 153 and n = 104). SOX8 mutations were found at increased frequency in oligozoospermic men (3.5%; P

Published
2018

5. Male Reproductive Health and Environmental Xenoestrogens

Author

Toppari, Jorma, Christiansen, Peter, Giwercman, Aleksander, Grandjean, Philippe, Guillette,, Louis J., Jégou, Bernard, Jensen, Tina K., Jouannet, Pierre, Keiding, Niels, Leffers, Henrik, McLachlan, John A., Meyer, Otto, Müller, Jørn, Meyts, Ewa Rajpert-De, Scheike, Thomas, Sharpe, Richard, Sumpter, John, and Skakkebæk, Niels E.

Published
1996
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6. Supplementary Table 4 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

Author

Sonne, Si Brask, primary, Almstrup, Kristian, primary, Dalgaard, Marlene, primary, Juncker, Agnieszka Sierakowska, primary, Edsgard, Daniel, primary, Ruban, Ludmila, primary, Harrison, Neil J., primary, Schwager, Christian, primary, Abdollahi, Amir, primary, Huber, Peter E., primary, Brunak, Søren, primary, Gjerdrum, Lise Mette, primary, Moore, Harry D., primary, Andrews, Peter W., primary, Skakkebaek, Niels E., primary, Meyts, Ewa Rajpert-De, primary, and Leffers, Henrik, primary

Published
2023
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8. Supplementary Figure 3 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

Author

Sonne, Si Brask, primary, Almstrup, Kristian, primary, Dalgaard, Marlene, primary, Juncker, Agnieszka Sierakowska, primary, Edsgard, Daniel, primary, Ruban, Ludmila, primary, Harrison, Neil J., primary, Schwager, Christian, primary, Abdollahi, Amir, primary, Huber, Peter E., primary, Brunak, Søren, primary, Gjerdrum, Lise Mette, primary, Moore, Harry D., primary, Andrews, Peter W., primary, Skakkebaek, Niels E., primary, Meyts, Ewa Rajpert-De, primary, and Leffers, Henrik, primary

Published
2023
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9. Supplementary Figure 2 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

Author

Sonne, Si Brask, primary, Almstrup, Kristian, primary, Dalgaard, Marlene, primary, Juncker, Agnieszka Sierakowska, primary, Edsgard, Daniel, primary, Ruban, Ludmila, primary, Harrison, Neil J., primary, Schwager, Christian, primary, Abdollahi, Amir, primary, Huber, Peter E., primary, Brunak, Søren, primary, Gjerdrum, Lise Mette, primary, Moore, Harry D., primary, Andrews, Peter W., primary, Skakkebaek, Niels E., primary, Meyts, Ewa Rajpert-De, primary, and Leffers, Henrik, primary

Published
2023
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10. Supplementary Table 1 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

Author

Sonne, Si Brask, primary, Almstrup, Kristian, primary, Dalgaard, Marlene, primary, Juncker, Agnieszka Sierakowska, primary, Edsgard, Daniel, primary, Ruban, Ludmila, primary, Harrison, Neil J., primary, Schwager, Christian, primary, Abdollahi, Amir, primary, Huber, Peter E., primary, Brunak, Søren, primary, Gjerdrum, Lise Mette, primary, Moore, Harry D., primary, Andrews, Peter W., primary, Skakkebaek, Niels E., primary, Meyts, Ewa Rajpert-De, primary, and Leffers, Henrik, primary

Published
2023
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11. Supplementary Table 3 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

Author

Sonne, Si Brask, primary, Almstrup, Kristian, primary, Dalgaard, Marlene, primary, Juncker, Agnieszka Sierakowska, primary, Edsgard, Daniel, primary, Ruban, Ludmila, primary, Harrison, Neil J., primary, Schwager, Christian, primary, Abdollahi, Amir, primary, Huber, Peter E., primary, Brunak, Søren, primary, Gjerdrum, Lise Mette, primary, Moore, Harry D., primary, Andrews, Peter W., primary, Skakkebaek, Niels E., primary, Meyts, Ewa Rajpert-De, primary, and Leffers, Henrik, primary

Published
2023
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12. Supplementary Table 2 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

Author

Sonne, Si Brask, primary, Almstrup, Kristian, primary, Dalgaard, Marlene, primary, Juncker, Agnieszka Sierakowska, primary, Edsgard, Daniel, primary, Ruban, Ludmila, primary, Harrison, Neil J., primary, Schwager, Christian, primary, Abdollahi, Amir, primary, Huber, Peter E., primary, Brunak, Søren, primary, Gjerdrum, Lise Mette, primary, Moore, Harry D., primary, Andrews, Peter W., primary, Skakkebaek, Niels E., primary, Meyts, Ewa Rajpert-De, primary, and Leffers, Henrik, primary

Published
2023
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14. Supplementary Figure 1 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

Author

Sonne, Si Brask, primary, Almstrup, Kristian, primary, Dalgaard, Marlene, primary, Juncker, Agnieszka Sierakowska, primary, Edsgard, Daniel, primary, Ruban, Ludmila, primary, Harrison, Neil J., primary, Schwager, Christian, primary, Abdollahi, Amir, primary, Huber, Peter E., primary, Brunak, Søren, primary, Gjerdrum, Lise Mette, primary, Moore, Harry D., primary, Andrews, Peter W., primary, Skakkebaek, Niels E., primary, Meyts, Ewa Rajpert-De, primary, and Leffers, Henrik, primary

Published
2023
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20. Testicular Cancer

Author

McGlynn, Katherine A., primary, Meyts, Ewa Rajpert-De, additional, and Stang, Andreas, additional

Published
2017
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22. Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline

Author

Giannoulatou, Eleni, McVean, Gilean, Taylor, Indira B., McGowan, Simon J., Maher, Geoffrey J., Iqbal, Zamin, Pfeifer, Susanne P., Turner, Isaac, Wright, Emma M. M. Burkitt, Shorto, Jennifer, Itani, Aysha, Turner, Karen, Gregory, Lorna, Buck, David, Meyts, Ewa Rajpert-De, Looijenga, Leendert H. J., Kerr, Bronwyn, Wilkie, Andrew O. M., and Goriely, Anne

Published
2013

23. A de novo paradigm for male infertility

Author

Oud, M.S., Smits, R.M., Smith, H.E., Mastrorosa, F.K., Holt, G.S., Houston, B.J., de Vries, P.F., Alobaidi, B.K.S., Batty, L.E., Ismail, H., Greenwood, J., Sheth, H., Mikulasova, A., Astuti, G.D.N., Gilissen, C., McEleny, K., Turner, H., Coxhead, J., Cockell, S., Braat, D.D.M., Fleischer, K., D’Hauwers, K.W.M., Schaafsma, E., Conrad, Donald F., Nagirnaja, Liina, Aston, Kenneth I., Carrell, Douglas T., Hotaling, James M., Jenkins, Timothy G., McLachlan, Rob, O’Bryan, Moira K., Schlegel, Peter N., Eisenberg, Michael L., Sandlow, Jay I., Jungheim, Emily S., Omurtag, Kenan R., Lopes, Alexandra M., Seixas, Susana, Carvalho, Filipa, Fernandes, Susana, Barros, Alberto, Gonçalves, João, Caetano, Iris, Pinto, Graça, Correia, Sónia, Laan, Maris, Punab, Margus, Meyts, Ewa Rajpert-De, Jørgensen, Niels, Almstrup, Kristian, Krausz, Csilla G., Jarvi, Keith A., Nagirnaja, L., Conrad, D.F., Friedrich, C., Kliesch, S., Aston, K.I., Riera-Escamilla, A., Krausz, C., Gonzaga-Jauregui, C., Santibanez-Koref, M., Elliott, D. J., Vissers, L.E.L.M., Tüttelmann, F., O’Bryan, M.K., Ramos, L., Xavier, M.J., van der Heijden, G.W., Veltman, J.A., NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centre for Toxicogenomics and Human Health (ToxOmics)

Subjects
Male, Chemistry(all), Gene Expression, General Physics and Astronomy, Cell Cycle Proteins, Bioinformatics, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], Male infertility, Loss of Function Mutation, Medicine, Exome, DNA sequencing, Azoospermia, Multidisciplinary, Disease genetics, RNA-Binding Proteins, Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6], Infertile Man, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], DNA-Binding Proteins, Adult, Science, Mutation, Missense, Genética Humana, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Physics and Astronomy(all), Article, General Biochemistry, Genetics and Molecular Biology, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Text mining, Exome Sequencing, Humans, Male Infertility, Genetic Predisposition to Disease, Spermatogenesis, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, Tumor Suppressor Proteins, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Oligospermia, General Chemistry, medicine.disease, Doenças Genéticas, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Case-Control Studies, Infertility, business
Abstract

De novo mutations are known to play a prominent role in sporadic disorders with reduced fitness. We hypothesize that de novo mutations play an important role in severe male infertility and explain a portion of the genetic causes of this understudied disorder. To test this hypothesis, we utilize trio-based exome sequencing in a cohort of 185 infertile males and their unaffected parents. Following a systematic analysis, 29 of 145 rare (MAF, Germline de novo mutations can impact individual fitness, but their role in human male infertility is understudied. Trio-based exome sequencing identifies many new candidate genes affecting male fertility, including an essential regulator of male germ cell pre-mRNA splicing.

Published
2022

26. Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure

Author

Hardy, Jimmaline J., Wyrwoll, Margot J., Mcfadden, William, Malcher, Agnieszka, Rotte, Nadja, Pollock, Nijole C., Munyoki, Sarah, Veroli, Maria V., Houston, Brendan J., Xavier, Miguel J., Kasak, Laura, Punab, Margus, Laan, Maris, Kliesch, Sabine, Schlegel, Peter, Jaffe, Thomas, Hwang, Kathleen, Vukina, Josip, Brieño-Enríquez, Miguel A., Orwig, Kyle, Yanowitz, Judith, Buszczak, Michael, Veltman, Joris A., Oud, Manon, Nagirnaja, Liina, Olszewska, Marta, O’Bryan, Moira K., Conrad, Donald F., Kurpisz, Maciej, Tüttelmann, Frank, Yatsenko, Alexander N., Aston, Kenneth I., Carrell, Douglas T., Hotaling, James M., Jenkins, Timothy G., McLachlan, Rob, Schlegel, Peter N., Eisenberg, Michael L., Sandlow, Jay I., Jungheim, Emily S., Omurtag, Kenan R., Lopes, Alexandra M., Seixas, Susana, Carvalho, Filipa, Fernandes, Susana, Barros, Alberto, Gonçalves, João, Caetano, Iris, Pinto, Graça, Correia, Sónia, Meyts, Ewa Rajpert-De, Jørgensen, Niels, Almstrup, Kristian, Krausz, Csilla G., Jarvi, Keith A., and on behalf of GEMINI Consortium

Subjects
Male, Models, Molecular, Protein Conformation, alpha-Helical, Gene Expression, medicine.disease_cause, Genome, Male infertility, Cohort Studies, Genes, X-Linked, Testis, Testosterone, Genetics (clinical), Exome sequencing, Spermatogenic Failure, Azoospermia, Genetics, 0303 health sciences, Mutation, education.field_of_study, 030305 genetics & heredity, Nuclear Proteins, Spermatozoa, 3. Good health, Meiosis, Adult, Population, Biology, Genomic Instability, Article, Frameshift mutation, 03 medical and health sciences, Exome Sequencing, medicine, Male Infertility, Animals, Humans, Protein Interaction Domains and Motifs, education, Spermatogenesis, Gene, Infertility, Male, 030304 developmental biology, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Base Sequence, Genome, Human, GCNA, Luteinizing Hormone, medicine.disease, Human genetics, Doenças Genéticas, Protein Conformation, beta-Strand, Follicle Stimulating Hormone
Abstract

Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266742/pdf/nihms-1705620.pdf GEMINI Consortium: Donald F Conrad, Liina Nagirnaja, Kenneth I Aston, Douglas T Carrell, James M Hotaling, Timothy G Jenkins, Rob McLachlan, Moira K O'Bryan, Peter N Schlegel, Michael L Eisenberg, Jay I Sandlow, Emily S Jungheim, Kenan R Omurtag, Alexandra M Lopes, Susana Seixas, Filipa Carvalho, Susana Fernandes, Alberto Barros, João Gonçalves, Iris Caetano, Graça Pinto, Sónia Correia, Maris Laan, Margus Punab, Ewa Rajpert-De Meyts, Niels Jørgensen, Kristian Almstrup, Csilla G Krausz, Keith A Jarvi. Member of GEMINI Consortium: João Gonçalves (INSA), lista completa na pág 1179. Male infertility impacts millions of couples yet, the etiology of primary infertility remains largely unknown. A critical element of successful spermatogenesis is maintenance of genome integrity. Here, we present a genomic study of spermatogenic failure (SPGF). Our initial analysis (n=176) did not reveal known gene-candidates but identifed a potentially signifcant single-nucleotide variant (SNV) in X-linked germ-cell nuclear antigen (GCNA). Together with a larger follow-up study (n=2049), 7 likely clinically relevant GCNA variants were identifed. GCNA is critical for genome integrity in male meiosis and knockout models exhibit impaired spermatogenesis and infertility. Single-cell RNA-seq and immunohistochemistry confrm human GCNA expression from spermatogonia to elongated spermatids. Five identifed SNVs were located in key functional regions, including N-terminal SUMO-interacting motif and C-terminal Spartan-like protease domain. Notably, variant p.Ala115ProfsTer7 results in an early frameshift, while Spartan-like domain missense variants p.Ser659Trp and p.Arg664Cys change conserved residues, likely afecting 3D structure. For variants within GCNA’s intrinsically disordered region, we performed computational modeling for consensus motifs. Two SNVs were predicted to impact the structure of these consensus motifs. All identifed variants have an extremely low minor allele frequency in the general population and 6 of 7 were not detected in>5000 biological fathers. Considering evidence from animal models, germ-cell-specifc expression, 3D modeling, and computational predictions for SNVs, we propose that identifed GCNA variants disrupt structure and function of the respective protein domains, ultimately arresting germ-cell division. To our knowledge, this is the frst study implicating GCNA, a key genome integrity factor, in human male infertility. This study was supported by The Eunice Kennedy Shriver NICHD Grant HD080755 (ANY), the Magee-Womens Research Institute University of Pittsburgh Start Up Fund (ANY), PA DoH Grant SAP4100085736 (ANY), NIH P50 Specialized Center Grant HD096723 (KO, ANY, DC, PNS, KH, and MBE), German Research Foundation Clinical Research Unit ‘Male Germ Cells’ grant DFG CRU326 (FT), National Science Centre in Poland, grants no.: 2017/26/D/NZ5/00789 (AM) and 2015/17/B/NZ2/01157; NCN 2020/37/B/NZ5/00549 (MK), Magee-Womens Research Institute University of Pittsburgh, Faculty Fellowship Award and NICHD T32 HD087194 (JH), GM125812 (MB), GM127569 (MB, JLY, and ANY), NIH R00H090289 (MABE), National Health and Medical Research Council Project grant APP1120356 (MKOB, JAV, and DC), UUKi Rutherford Fund Fellowship (BJH), Estonian Research Council, grants IUT34-12 and PRG1021 (ML), and The Netherlands Organization for Scientifc Research grant no.: 918-15-667 as well as an Investigator Award in Science from the Wellcome Trust grant no.: 209451 (JAV). Computational analysis was supported in part by the University of Pittsburgh Center for Research Computing through the resources provided. info:eu-repo/semantics/publishedVersion

Published
2021

37. Contributors

Author

Aiello, Lloyd Paul, primary, Alexander, Erik K., additional, Allan, Carolyn A., additional, Allolio, Bruno, additional, Angelos, Peter, additional, Appu, Sree, additional, Auchus, Richard J., additional, Avruch, Joseph, additional, Axelrod, Lloyd, additional, Bahn, Rebecca S., additional, Baker, H.W.G., additional, Barnes, Randall B., additional, Bastepe, Murat, additional, Baxter, John D., additional, Beck-Peccoz, Paolo, additional, Bell, Graeme I., additional, Bilezikian, John P., additional, Bloom, Stephen R., additional, Blum, Manfred, additional, Bonnema, Steen J., additional, Botero, Diego, additional, Bouillon, Roger, additional, Boulton, Andrew J.M., additional, Braunstein, Glenn D., additional, Bringhurst, F. Richard, additional, Broekmans, Frank J., additional, Bronstein, Marcello D., additional, Brown, Edward M., additional, Bui, Chuong, additional, Burch, Col. Henry B., additional, Burger, Henry G., additional, Burney, Richard O., additional, Buse, John B., additional, Butler, Peter C., additional, Cappabianca, Paolo, additional, Caramori, Maria Luiza Avancini, additional, Carey, Robert M., additional, Carlton, Esther, additional, Carmody, David, additional, Caro, Jose F., additional, Cavagnini, Francesco, additional, Cavallerano, Jerry, additional, Cavallo, Luigi M., additional, Chan, Shu Jin, additional, Chang, R. Jeffrey, additional, Chapurlat, Roland D., additional, Chatterjee, V. Krishna, additional, Chiovato, Luca, additional, Cho, Kyung J., additional, Christophe, Daniel, additional, Chung, Teng-Teng, additional, Cidlowski, John A., additional, Clark, Adrian J.L., additional, Clark, Peter E., additional, Clemmons, David R., additional, Considine, Robert V., additional, Copinschi, Georges, additional, Copps, Kyle D., additional, Courtney, C. Hamish, additional, Cuttler, Leona, additional, Daley, Melita L., additional, Dattani, Mehul, additional, Davis, Stephen N., additional, de Divitiis, Oreste, additional, De Felice, Mario, additional, DeFronzo, Ralph A., additional, J. De Groot, Leslie, additional, de Kretser, David, additional, Delli, Ahmed J., additional, Delmas, Pierre D., additional, Demay, Marie B., additional, Devroey, Paul, additional, Di Lauro, Roberto, additional, Dinneen, Sean F., additional, Dumont, Jacques E., additional, Dungan, Kathleen M., additional, Drucker, Daniel J., additional, Econs, Michael J., additional, Ehrmann, David A., additional, Eisenhofer, Graeme, additional, Erickson, Gregory F., additional, Eriksson, Barbro, additional, Espiner, Eric, additional, Esposito, Felice, additional, Esser, Victoria, additional, Eugster, Erica A., additional, Farooqi, Sadaf, additional, Fassnacht, Martin, additional, Fauser, Bart C.J.M., additional, Fenzi, Gianfranco, additional, Ferrannini, Ele, additional, Findlay, David M., additional, Finlayson, Courtney, additional, Fisher, Delbert A., additional, Forest, Maguelone G., additional, Foster, Daniel W., additional, Freeman, Mason Wright, additional, Frydenberg, Mark, additional, Fuller, Peter, additional, Gagel, Robert F., additional, Gaglia, Jason L., additional, Galizia, Gianluigi, additional, Gao, Chuanyun, additional, Gardella, Thomas J., additional, Gaylinn, Bruce D., additional, Genant, Harry K., additional, German, Michael S., additional, Ghatei, Mohammad A., additional, Giudice, Linda C., additional, Glasier, Anna, additional, Glorieux, Francis H., additional, González-Maeso, Javier, additional, Gooren, Louis J., additional, Gordon, David F., additional, Gregerson, Karen A., additional, Gross, Milton D., additional, Grossman, Ashley, additional, Guimarães, Valéria C., additional, Gurnell, Mark, additional, Haddad, Nadine, additional, Haisenleder, Daniel J., additional, Handelsman, David J., additional, Hanks, John B., additional, Hannon, Mark John, additional, Hayward, Simon W., additional, Hebrok, Matthias, additional, Hegedüs, Laszlo, additional, Hennemann, Georg, additional, Herndon, Maria K., additional, Hindmarsh, Peter, additional, Ho, Ken K.Y., additional, Horseman, Nelson D., additional, Horwitz, Mara J., additional, Hu, Mimi, additional, Hughes, Ieuan A., additional, Hupfeld, Christopher J., additional, Hussain, Hero K., additional, Illingworth, Peter, additional, Jameson, J. Larry, additional, Josso, Nathalie, additional, Jüppner, Harald, additional, Kalish, Jeffrey, additional, Kaplan, Edwin L., additional, Kerr, Jeffrey B., additional, Klein, Ronald, additional, Knobel, Meyer, additional, Kolibianakis, Efstratios, additional, Kopchick, John J., additional, Kopp, Peter, additional, Korbonits, Márta, additional, Korobkin, Melvyn, additional, Krane, Stephen M., additional, Krohn, Knut, additional, Kronenberg, Henry M., additional, Kyriakis, John M., additional, Lau, Sue Lynn, additional, Lazarus, John H., additional, Learoyd, Diana L., additional, Lebovitz, Harold E., additional, Lee, Paul, additional, Lernmark, Åke, additional, Lewis-Tuffin, Laura J., additional, Lu, Zhi-Liang, additional, Macchia, Paolo Emidio, additional, Maclaren, Noel K., additional, Maenhaut, Carine, additional, Maes, Christa, additional, Main, Katharina M., additional, Malchoff, Carl D., additional, Malchoff, Diana Mark, additional, Malik, Rayaz A., additional, Mandel, Susan J., additional, Mantzoros, Christos, additional, Maratos-Flier, Eleftheria, additional, Marchisotta, Stefania, additional, Marinò, Michele, additional, Marshall, John C., additional, Martin, Thomas F.J., additional, Martin, T. John, additional, Martos-Moreno, Gabriel Á., additional, Mathias, Christopher J., additional, Mauer, Michael, additional, McGee, Elizabeth A., additional, McKenna, Neil J., additional, McLachlan, Robert I., additional, Medeiros-Neto, Geraldo, additional, Meier, Juris J., additional, Melmed, Shlomo, additional, Metzger, Boyd E., additional, Millar, Robert, additional, Miller, Walter L., additional, Misra, Madhusmita, additional, Molitch, Mark E., additional, Moore, David D., additional, Morris, Damian G., additional, Munck, Allan U., additional, Nakamoto, Jon, additional, Náray-Fejes-Tóth, Anikó, additional, Nass, Ralf, additional, Nathan, David M., additional, New, Maria I., additional, Nguyen, Carolyn, additional, Nieman, Lynnette K., additional, Nilson, John H., additional, Norton, Jeffrey A., additional, Oakley, Robert H., additional, Öberg, Kjell, additional, Olefsky, Jerrold M., additional, O’Rahilly, Stephen, additional, Ozcan, Umut, additional, Pacak, Karel, additional, Pacini, Furio, additional, Padia, Shetal H., additional, Paschke, Ralf, additional, Pawson, Adam, additional, Peck, Alison C., additional, Giraldi, Francesca Pecori, additional, Persani, Luca, additional, Phelps, Richard L., additional, Philipson, Louis H., additional, Phillips, Kevin, additional, Pinchera, Aldo, additional, Pomposelli, Frank B., additional, Potts, John T., additional, Quigley, Charmian A., additional, Quinkler, Marcus, additional, Quirk, Christine Campion, additional, Rademaker, Miriam T., additional, Meyts, Ewa Rajpert-De, additional, Ravussin, Eric, additional, Ray, David W., additional, Reame, Nancy King, additional, Refetoff, Samuel, additional, Retnakaran, Ravi, additional, Rey, Rodolfo A., additional, Rhodes, Christopher J., additional, Ridgway, E. Chester, additional, Risbridger, Gail P., additional, Rizza, Robert A., additional, Robinson, Bruce, additional, Roger, Pierre P., additional, Rosenfeld, Michael G., additional, Rosenfield, Robert L., additional, Rosing, James H., additional, Rossing, Peter, additional, Rubin, Robert T., additional, Ruderman, Neil, additional, Russo, Irma H., additional, Russo, Jose, additional, Salameh, Wael Antoine, additional, Salusky, Isidoro B., additional, Samuels, Mary H., additional, Santen, Richard J., additional, Santoro, Nanette, additional, Sarapura, Virginia D., additional, Sealfon, Stuart C., additional, Sexton, Patrick M., additional, Shulman, Gerald I., additional, Silva, Paolo S., additional, Silverberg, Shonni J., additional, Singer, Frederick R., additional, Skakkebaek, Niels E., additional, Skowronska-Krawczyk, Dorota, additional, Smith, Carolyn L., additional, Smith, Philip W., additional, Smith, Roger, additional, Smith, Steven R., additional, Snyder, Peter J., additional, Stanhope, Richard, additional, St-Arnaud, René, additional, Steiner, Donald F., additional, Stevens, Adam, additional, Stewart, Andrew F., additional, Stewart, Paul M., additional, St. Germain, Donald L., additional, Stockigt, Jim, additional, Strauss, Jerome F., additional, Swiersz, Lillian Marie, additional, Tacon, Lyndal J., additional, Taheri, Shahrad, additional, Thakker, Rajesh V., additional, Thompson, Chris, additional, Thorner, Michael O., additional, Timmers, Henri J.L.M., additional, Toppari, Jorma, additional, Traggiai, Cristina, additional, Traub, Michael L., additional, Tseng, Yolanda, additional, Turek, Fred W., additional, Van Cauter, Eve, additional, Van den Berghe, Greet, additional, Van Steirteghem, André C., additional, Vassart, Gilbert, additional, Vilain, Eric, additional, Visser, Theo J., additional, Wajnrajch, Michael P., additional, Wand, Gary, additional, Webb, Paul, additional, Weetman, Anthony P., additional, Weigel, Nancy L., additional, Weir, Gordon C., additional, Weiss, Roy E., additional, Wesseling-Perry, Katherine, additional, White, Anne, additional, White, Kenneth E., additional, White, Morris F., additional, Whyte, Michael P., additional, Wiersinga, Wilmar M., additional, Wolfsdorf, Joseph I., additional, and Zinman, Bernard, additional

Published
2010
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47. Is human fecundity declining?

Author

Skakkebæk, Niels E., Jørgensen, Niels, Main, Katharina M., Meyts, Ewa Rajpert-De, Leffers, Henrik, Andersson, Anna-Maria, Juul, Anders, Carlsen, Elisabeth, Mortensen, Gerda Krog, Jensen, Tina Kold, and Toppari, Jorma

Published
2006

Catalog

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