Search

Your search keyword '"Meyre, David"' showing total 806 results
Start Over Author "Meyre, David"
806 results on '"Meyre, David"'

1. Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

Author

Bradfeld, Jonathan P., Kember, Rachel L., Ulrich, Anna, Balkhiyarova, Zhanna, Alyass, Akram, Aris, Izzuddin M., Bell, Joshua A., Broadaway, K. Alaine, Chen, Zhanghua, Chai, Jin-Fang, Davies, Neil M., Fernandez-Orth, Dietmar, Bustamante, Mariona, Fore, Ruby, Ganguli, Amitavo, Heiskala, Anni, Hottenga, Jouke-Jan, Íñiguez, Carmen, Kobes, Sayuko, Leinonen, Jaakko, Lowry, Estelle, Lyytikainen, Leo-Pekka, Mahajan, Anubha, Pitkänen, Niina, Schnurr, Theresia M., Have, Christian Theil, Strachan, David P., Thiering, Elisabeth, Vogelezang, Suzanne, Wade, Kaitlin H., Wang, Carol A., Wong, Andrew, Holm, Louise Aas, Chesi, Alessandra, Choong, Catherine, Cruz, Miguel, Elliott, Paul, Franks, Steve, Frithiof-Bøjsøe, Christine, Gauderman, W. James, Glessner, Joseph T., Gilsanz, Vicente, Griesman, Kendra, Hanson, Robert L., Kaakinen, Marika, Kalkwarf, Heidi, Kelly, Andrea, Kindler, Joseph, Kähönen, Mika, Lanca, Carla, Lappe, Joan, Lee, Nanette R., McCormack, Shana, Mentch, Frank D., Mitchell, Jonathan A., Mononen, Nina, Niinikoski, Harri, Oken, Emily, Pahkala, Katja, Sim, Xueling, Teo, Yik-Ying, Baier, Leslie J., van Beijsterveldt, Toos, Adair, Linda S., Boomsma, Dorret I., de Geus, Eco, Guxens, Mònica, Eriksson, Johan G., Felix, Janine F., Gilliland, Frank D., Hansen, Torben, Hardy, Rebecca, Hivert, Marie-France, Holm, Jens-Christian, Jaddoe, Vincent W. V., Järvelin, Marjo-Riitta, Lehtimäki, Terho, Mackey, David A., Meyre, David, Mohlke, Karen L., Mykkänen, Juha, Oberfeld, Sharon, Pennell, Craig E., Perry, John R. B., Raitakari, Olli, Rivadeneira, Fernando, Saw, Seang-Mei, Sebert, Sylvain, Shepherd, John A., Standl, Marie, Sørensen, Thorkild I. A., Timpson, Nicholas J., Torrent, Maties, Willemsen, Gonneke, Hypponen, Elina, Power, Chris, McCarthy, Mark I., Freathy, Rachel M., Widén, Elisabeth, Hakonarson, Hakon, Prokopenko, Inga, Voight, Benjamin F., Zemel, Babette S., Grant, Struan F. A., and Cousminer, Diana L.

Published
2024
Full Text
View/download PDF

2. Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

Author

Bradfield, Jonathan P., Kember, Rachel L., Ulrich, Anna, Balkhiyarova, Zhanna, Alyass, Akram, Aris, Izzuddin M., Bell, Joshua A., Broadaway, K. Alaine, Chen, Zhanghua, Chai, Jin-Fang, Davies, Neil M., Fernandez-Orth, Dietmar, Bustamante, Mariona, Fore, Ruby, Ganguli, Amitavo, Heiskala, Anni, Hottenga, Jouke-Jan, Íñiguez, Carmen, Kobes, Sayuko, Leinonen, Jaakko, Lowry, Estelle, Lyytikainen, Leo-Pekka, Mahajan, Anubha, Pitkänen, Niina, Schnurr, Theresia M., Have, Christian Theil, Strachan, David P., Thiering, Elisabeth, Vogelezang, Suzanne, Wade, Kaitlin H., Wang, Carol A., Wong, Andrew, Holm, Louise Aas, Chesi, Alessandra, Choong, Catherine, Cruz, Miguel, Elliott, Paul, Franks, Steve, Frithioff-Bøjsøe, Christine, Gauderman, W. James, Glessner, Joseph T., Gilsanz, Vicente, Griesman, Kendra, Hanson, Robert L., Kaakinen, Marika, Kalkwarf, Heidi, Kelly, Andrea, Kindler, Joseph, Kähönen, Mika, Lanca, Carla, Lappe, Joan, Lee, Nanette R., McCormack, Shana, Mentch, Frank D., Mitchell, Jonathan A., Mononen, Nina, Niinikoski, Harri, Oken, Emily, Pahkala, Katja, Sim, Xueling, Teo, Yik-Ying, Baier, Leslie J., van Beijsterveldt, Toos, Adair, Linda S., Boomsma, Dorret I., de Geus, Eco, Guxens, Mònica, Eriksson, Johan G., Felix, Janine F., Gilliland, Frank D., Biobank, Penn Medicine, Hansen, Torben, Hardy, Rebecca, Hivert, Marie-France, Holm, Jens-Christian, Jaddoe, Vincent W. V., Järvelin, Marjo-Riitta, Lehtimäki, Terho, Mackey, David A., Meyre, David, Mohlke, Karen L., Mykkänen, Juha, Oberfield, Sharon, Pennell, Craig E., Perry, John R. B., Raitakari, Olli, Rivadeneira, Fernando, Saw, Seang-Mei, Sebert, Sylvain, Shepherd, John A., Standl, Marie, Sørensen, Thorkild I. A., Timpson, Nicholas J., Torrent, Maties, Willemsen, Gonneke, Hypponen, Elina, Power, Chris, McCarthy, Mark I., Freathy, Rachel M., Widén, Elisabeth, Hakonarson, Hakon, Prokopenko, Inga, Voight, Benjamin F., Zemel, Babette S., Grant, Struan F. A., and Cousminer, Diana L.

Published
2024
Full Text
View/download PDF

3. Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis

Author

Broséus, Julien, Hergalant, Sébastien, Vogt, Julia, Tausch, Eugen, Kreuz, Markus, Mottok, Anja, Schneider, Christof, Dartigeas, Caroline, Roos-Weil, Damien, Quinquenel, Anne, Moulin, Charline, Ott, German, Blanchet, Odile, Tomowiak, Cécile, Lazarian, Grégory, Rouyer, Pierre, Chteinberg, Emil, Bernhart, Stephan H., Tournilhac, Olivier, Gauchotte, Guillaume, Lomazzi, Sandra, Chapiro, Elise, Nguyen-Khac, Florence, Chery, Céline, Davi, Frédéric, Hunault, Mathilde, Houlgatte, Rémi, Rosenwald, Andreas, Delmer, Alain, Meyre, David, Béné, Marie-Christine, Thieblemont, Catherine, Lichter, Peter, Ammerpohl, Ole, Guéant, Jean-Louis, Guièze, Romain, Martin-Subero, José Ignacio, Cymbalista, Florence, Feugier, Pierre, Siebert, Reiner, and Stilgenbauer, Stephan

Published
2023
Full Text
View/download PDF

4. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Author

Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Moore, Tim, Hemerich, Daiane, Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Ahluwalia, Tarunveer S., Bartz, Traci M., Bentley, Amy R., Bielak, Lawrence F., Chong, Mike, Chu, Audrey Y., Berry, Diane, Dorajoo, Rajkumar, Dueker, Nicole D., Kasbohm, Elisa, Feenstra, Bjarke, Feitosa, Mary F., Gieger, Christian, Graff, Mariaelisa, Hall, Leanne M., Haller, Toomas, Hartwig, Fernando P., Hillis, David A., Huikari, Ville, Heard-Costa, Nancy, Holzapfel, Christina, Jackson, Anne U., Johansson, Åsa, Jørgensen, Anja Moltke, Kaakinen, Marika A., Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Koolhaas, Chantal M., Kutalik, Zoltan, Lagou, Vasiliki, Lind, Penelope A., Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Metzendorf, Christoph, Monroe, Kristine R., Pacolet, Alexander, Pérusse, Louis, Pool, Rene, Richmond, Rebecca C., Rivera, Natalia V., Robiou-du-Pont, Sebastien, Schraut, Katharina E., Schulz, Christina-Alexandra, Stringham, Heather M., Tanaka, Toshiko, Teumer, Alexander, Turman, Constance, van der Most, Peter J., Vanmunster, Mathias, van Rooij, Frank J. A., van Vliet-Ostaptchouk, Jana V., Zhang, Xiaoshuai, Zhao, Jing-Hua, Zhao, Wei, Balkhiyarova, Zhanna, Balslev-Harder, Marie N., Baumeister, Sebastian E., Beilby, John, Blangero, John, Boomsma, Dorret I., Brage, Soren, Braund, Peter S., Brody, Jennifer A., Bruinenberg, Marcel, Ekelund, Ulf, Liu, Ching-Ti, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Esko, Tõnu, Enroth, Stefan, Faul, Jessica D., Fernandez-Rhodes, Lindsay, Fohner, Alison E., Franco, Oscar H., Galesloot, Tessel E., Gordon, Scott D., Grarup, Niels, Hartman, Catharina A., Heiss, Gerardo, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Joshi, Peter K., Jung, Taeyeong, Kähönen, Mika, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Kuusisto, Johanna, Launer, Lenore J., Li, Aihua, Linneberg, Allan, Luan, Jian’an, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Moscati, Arden, Musk, Bill, Nelson, Christopher P., Nolte, Ilja M., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Reedik, Mägi, Reiner, Alex P., Ridker, Paul M., Rudan, Igor, Ryan, Kathy, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Sidney, Stephen, Siggeirsdottir, Kristin, Smith, Albert V., Smith, Jennifer A., Sonestedt, Emily, Strøm, Marin, Tai, E. Shyong, Teo, Koon K., Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Uitterlinden, Andre G., Vangipurapu, Jagadish, van Schoor, Natasja, Völker, Uwe, Willemsen, Gonneke, Williams, Kayleen, Wong, Quenna, Xu, Huichun, Young, Kristin L., Yuan, Jian Min, Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bis, Joshua C., Boehnke, Michael, Bouchard, Claude, Chasman, Daniel I., Smith, George Davey, de Geus, Eco J. C., Deldicque, Louise, Dörr, Marcus, Evans, Michele K., Ferrucci, Luigi, Fornage, Myriam, Fox, Caroline, Garland, Jr, Theodore, Gudnason, Vilmundur, Gyllensten, Ulf, Hansen, Torben, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Johnson, W. Craig, Kardia, Sharon L. R., Kiemeney, Lambertus A., Laakso, Markku, Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Oldehinkel, Albertine J., Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Penninx, Brenda W. J. H., Pers, Tune H., Polasek, Ozren, Prokopenko, Inga, Rotimi, Charles N., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Timpson, Nicholas J., van Dam, Rob M., van der Velde, Nathalie, van Duijn, Cornelia M., Vollenweider, Peter, Völzke, Henry, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Weir, David R., Wichmann, Heinz-Erich, Wilson, James F., Hevener, Andrea L., Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I., Loos, Ruth J. F., and Hoed, Marcel den

Published
2022
Full Text
View/download PDF

5. Body mass index trajectories and their predictors in undergraduate students from Canada: Results from the GENEiUS study.

Author

Sharma, Tanmay, Morassut, Rita E., Langlois, Christine, and Meyre, David

Subjects
BODY weight -- Risk factors, RISK assessment, WEIGHT loss, BODY mass index, RESEARCH funding, T-test (Statistics), UNDERGRADUATES, SCIENTIFIC observation, LOGISTIC regression analysis, REGULATION of body weight, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, CONFIDENCE intervals, NONPARAMETRIC statistics, WEIGHT gain
Abstract

Objective: To explore the patterns and predictors of body mass index (BMI) change among undergraduate students from Ontario (Canada). Participants: 68 undergraduate students were followed longitudinally for 3 years with anthropometric data collected bi-annually. Methods: BMI measurements were plotted to generate individual BMI trajectory curves, which were categorized, based on the observed trajectory pattern. Within and between group comparisons of BMI were conducted via nonparametric paired tests. The association of baseline BMI, sex, and ethnicity with BMI trajectory type was assessed using multinomial logistic regression. Results: Four BMI trajectory types were observed: "stable weight" (n = 15, 22.1%), "weight gain" (n = 30, 44.1%), "weight loss" (n = 12, 17.6%), and "weight cycling" (n = 11, 16.2%) trajectories. Higher baseline BMI was significantly associated with the "weight gain," "weight loss," and the "weight cycling" trajectories as compared to the "stable weight" trajectory type. Conclusions: Our findings demonstrate an association between high baseline BMI and "nonstable" subsequent BMI change patterns among Canadian students. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Medical semiology of patients with monogenic obesity: A systematic review.

Author

Renard, Emeline, Thevenard‐Berger, Ariane, and Meyre, David

Subjects
DIETARY patterns, FOOD habits, GENETIC testing, RESPIRATORY diseases, SYMPTOMS
Abstract

Summary: Patients with monogenic obesity display numerous medical features on top of hyperphagic obesity, but no study to date has provided an exhaustive description of their semiology. Two reviewers independently conducted a systematic review of MEDLINE, Embase, and Web of Science Core Collection databases from inception to January 2022 to identify studies that described symptoms of patients carrying pathogenic mutations in at least one of eight monogenic obesity genes (ADCY3, LEP, LEPR, MC3R, MC4R, MRAP2, PCSK1, and POMC). Of 5207 identified references, 269 were deemed eligible after title and abstract screening, full‐text reading, and risk of bias and quality assessment. Data extraction included mutation spectrum and mode of inheritance, clinical presentation (e.g., anthropometry, energy intake and eating behaviors, digestive function, puberty and fertility, cognitive features, infectious diseases, morphological characteristics, chronic respiratory disease, and cardiovascular disease), biological characteristics (metabolic profile, endocrinology, hematology), radiological features, and treatments. The review provides an exhaustive description of mandatory, non‐mandatory, and unique symptoms in heterozygous and homozygous carriers of mutation in eight monogenic obesity genes. This information is critical to help clinicians to orient genetic testing in subsets of patients with suspected monogenic obesity and provide actionable treatments (e.g., recombinant leptin and MC4R agonist). [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. IBD and obesity: the vicious cycle

Author

Sequier, Léa, additional, Caron, Bénédicte, additional, Caillo, Ludovic, additional, Altwegg, Romain, additional, Peyrin-Biroulet, Laurent, additional, Meyre, David, additional, and Arnone, Djésia, additional

Published
2024
Full Text
View/download PDF

16. Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

Author

Dimas, Antigone S, Lagou, Vasiliki, Barker, Adam, Knowles, Joshua W, Mägi, Reedik, Hivert, Marie-France, Benazzo, Andrea, Rybin, Denis, Jackson, Anne U, Stringham, Heather M, Song, Ci, Fischer-Rosinsky, Antje, Boesgaard, Trine Welløv, Grarup, Niels, Abbasi, Fahim A, Assimes, Themistocles L, Hao, Ke, Yang, Xia, Lecoeur, Cécile, Barroso, Inês, Bonnycastle, Lori L, Böttcher, Yvonne, Bumpstead, Suzannah, Chines, Peter S, Erdos, Michael R, Graessler, Jurgen, Kovacs, Peter, Morken, Mario A, Narisu, Narisu, Payne, Felicity, Stancakova, Alena, Swift, Amy J, Tönjes, Anke, Bornstein, Stefan R, Cauchi, Stéphane, Froguel, Philippe, Meyre, David, Schwarz, Peter EH, Häring, Hans-Ulrich, Smith, Ulf, Boehnke, Michael, Bergman, Richard N, Collins, Francis S, Mohlke, Karen L, Tuomilehto, Jaakko, Quertemous, Thomas, Lind, Lars, Hansen, Torben, Pedersen, Oluf, Walker, Mark, Pfeiffer, Andreas FH, Spranger, Joachim, Stumvoll, Michael, Meigs, James B, Wareham, Nicholas J, Kuusisto, Johanna, Laakso, Markku, Langenberg, Claudia, Dupuis, Josée, Watanabe, Richard M, Florez, Jose C, Ingelsson, Erik, McCarthy, Mark I, Prokopenko, Inga, and Investigators, on behalf of the MAGIC

Subjects
Biomedical and Clinical Sciences, Genetics, Diabetes, Autoimmune Disease, Clinical Research, Prevention, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Alleles, Cluster Analysis, Diabetes Mellitus, Type 2, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Insulin, Insulin Resistance, Insulin Secretion, Insulin-Secreting Cells, Male, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors, Transcription Factors, MAGIC Investigators, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences
Abstract

Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin processing, insulin secretion, and insulin sensitivity. We included data from up to 58,614 nondiabetic subjects with basal measures and 17,327 with dynamic measures. We used additive genetic models with adjustment for sex, age, and BMI, followed by fixed-effects, inverse-variance meta-analyses. Cluster analyses grouped risk loci into five major categories based on their relationship to these continuous glycemic phenotypes. The first cluster (PPARG, KLF14, IRS1, GCKR) was characterized by primary effects on insulin sensitivity. The second cluster (MTNR1B, GCK) featured risk alleles associated with reduced insulin secretion and fasting hyperglycemia. ARAP1 constituted a third cluster characterized by defects in insulin processing. A fourth cluster (TCF7L2, SLC30A8, HHEX/IDE, CDKAL1, CDKN2A/2B) was defined by loci influencing insulin processing and secretion without a detectable change in fasting glucose levels. The final group contained 20 risk loci with no clear-cut associations to continuous glycemic traits. By assembling extensive data on continuous glycemic traits, we have exposed the diverse mechanisms whereby type 2 diabetes risk variants impact disease predisposition.

Published
2014

22. A genome-wide association meta-analysis identifies new childhood obesity loci

Author

Bradfield, Jonathan P, Taal, H Rob, Timpson, Nicholas J, Scherag, Andre, Lecoeur, Cecile, Warrington, Nicole M, Hypponen, Elina, Holst, Claus, Valcarcel, Beatriz, Thiering, Elisabeth, Salem, Rany M, Schumacher, Fredrick R, Cousminer, Diana L, Sleiman, Patrick MA, Zhao, Jianhua, Berkowitz, Robert I, Vimaleswaran, Karani S, Jarick, Ivonne, Pennell, Craig E, Evans, David M, St Pourcain, Beate, Berry, Diane J, Mook-Kanamori, Dennis O, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, Andre G, van Duijn, Cornelia M, van der Valk, Ralf JP, de Jongste, Johan C, Postma, Dirkje S, Boomsma, Dorret I, Gauderman, W James, Hassanein, Mohamed T, Lindgren, Cecilia M, Magi, Reedik, Boreham, Colin AG, Neville, Charlotte E, Moreno, Luis A, Elliott, Paul, Pouta, Anneli, Hartikainen, Anna-Liisa, Li, Mingyao, Raitakari, Olli, Lehtimaki, Terho, Eriksson, Johan G, Palotie, Aarno, Dallongeville, Jean, Das, Shikta, Deloukas, Panos, McMahon, George, Ring, Susan M, Kemp, John P, Buxton, Jessica L, Blakemore, Alexandra IF, Bustamante, Mariona, Guxens, Monica, Hirschhorn, Joel N, Gillman, Matthew W, Kreiner-Moller, Eskil, Bisgaard, Hans, Gilliland, Frank D, Heinrich, Joachim, Wheeler, Eleanor, Barroso, Ines, O'Rahilly, Stephen, Meirhaeghe, Aline, Sorensen, Thorkild IA, Power, Chris, Palmer, Lyle J, Hinney, Anke, Widen, Elisabeth, Farooqi, I Sadaf, McCarthy, Mark I, Froguel, Philippe, Meyre, David, Hebebrand, Johannes, Jarvelin, Marjo-Riitta, Jaddoe, Vincent WV, Smith, George Davey, Hakonarson, Hakon, and Grant, Struan FA

Subjects
Biological Sciences, Genetics, Pediatric, Nutrition, Obesity, Human Genome, Metabolic and endocrine, Oral and gastrointestinal, Stroke, Cancer, Cardiovascular, Adolescent, Adult, Body Mass Index, Case-Control Studies, Genetic Loci, Genetic Markers, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Young Adult, Early Growth Genetics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (

Published
2012

23. A systematic survey of the methods literature on the reporting quality and optimal methods of handling participants with missing outcome data for continuous outcomes in randomized controlled trials

Author

Zhang, Yuqing, Alyass, Akram, Vanniyasingam, Thuva, Sadeghirad, Behnam, Flórez, Iván D., Pichika, Sathish Chandra, Kennedy, Sean Alexander, Abdulkarimova, Ulviya, Zhang, Yuan, Iljon, Tzvia, Morgano, Gian Paolo, Colunga Lozano, Luis E., Aloweni, Fazila Abu Bakar, Lopes, Luciane C., Yepes-Nuñez, Juan José, Fei, Yutong, Wang, Li, Kahale, Lara A., Meyre, David, Akl, Elie A., Thabane, Lehana, and Guyatt, Gordon H.

Published
2017
Full Text
View/download PDF

25. MICI et obésité : le cercle vicieux.

Author

Sequier, Léa, Caron, Bénédicte, Caillo, Ludovic, Altwegg, Romain, Peyrin-Biroulet, Laurent, Meyre, David, and Arnone, Djésia

Subjects
BIOTHERAPY, OBESITY, SURGERY
Abstract

Copyright of Hépato-Gastro & Oncologie Digestive is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
Full Text
View/download PDF

32. Association of total and pancreatic serum amylase enzymatic activity with insulin resistance and the glucose and insulin responses to oral starch test in Mexican children

Author

Locia‐Morales, Daniel, primary, Vázquez‐Moreno, Miguel, additional, González‐Dzib, Roxana, additional, Domínguez‐Hernández, Carmen, additional, Pérez‐Herrera, Aleyda, additional, Robles‐Ramírez, Roberto J., additional, Rocha‐Cruz, Alberto, additional, Meyre, David, additional, Flores‐Alfaro, Eugenia, additional, and Cruz, Miguel, additional

Published
2022
Full Text
View/download PDF

37. A Polymorphism within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels

Author

Bouatia-Naji, Nabila, Rocheleau, Ghislain, Van Lommel, Leentje, Lemaire, Katleen, Schuit, Frans, Cavalcanti-Proença, Christine, Marchand, Marion, Hartikainen, Anna-Liisa, Sovio, Ulla, De Graeve, Franck, Rung, Johan, Vaxillaire, Martine, Tichet, Jean, Marre, Michel, Balkau, Beverley, Weill, Jacques, Elliott, Paul, Jarvelin, Marjo-Riitta, Meyre, David, Polychronakos, Constantin, Dina, Christian, Sladek, Robert, and Froguel, Philippe

Published
2008
Full Text
View/download PDF

39. Physical activity and sedentary behavior; mechanistic insights and role in disease prevention

Author

Hoed, Marcel den, primary, Wang, Zhe, additional, Emmerich, Andrew, additional, Pillon, Nicolas, additional, Moore, Timothy, additional, Hemerich, Daiane, additional, Cornelis, Marilyn, additional, Mazzaferro, Eugenia, additional, Broos, Siacia, additional, Ameur, Adam, additional, Bandinelli, Stefania, additional, Bis, Joshua, additional, Boehnke, Michael, additional, Bouchard, Claude, additional, Chasman, Daniel, additional, de Geus, Eco, additional, Deldicque, Louise, additional, Dörr, Marcus, additional, Evans, Michele, additional, Ferrucci, Luigi, additional, Fornage, Myriam, additional, Fox, Caroline, additional, Garland, Theodore, additional, Gyllensten, Ulf, additional, Hansen, Torben, additional, Hayward, Caroline, additional, Horta, Bernardo, additional, Hypponen, Elina, additional, Johnson, W. Craig, additional, Kardia, Sharon, additional, Kiemeney, Lambertus, additional, Laakso, Markku, additional, Langenberg, Claudia, additional, Lehtimäki, Terho, additional, Marchand, Loic Le, additional, Magnusson, Patrik, additional, Martin, Nicholas, additional, Melbye, Mads, additional, Metspalu, Andres, additional, Meyre, David, additional, North, Kari, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine, additional, Orho-Melander, Marju, additional, Pare, Guillaume, additional, Park, Taesung, additional, Pedersen, Oluf, additional, Penninx, Brenda, additional, Pers, Tune, additional, Polasek, Ozren, additional, Prokopenko, Inga, additional, Rotimi, Charles, additional, Samani, Nilesh, additional, Sim, Xueling, additional, Smith, George Davey, additional, Snieder, Harold, additional, Sorensen, Thorkild, additional, Spector, Tim, additional, Timpson, Nicholas, additional, Dam, Rob van, additional, Velde, Nathalie van der, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Voortman, Trudy, additional, Waeber, Gerard, additional, Wareham, Nick, additional, Weir, David, additional, Wichmann, Erich, additional, Wilson, James, additional, Hevener, Andrea, additional, Krook, Anna, additional, Zierath, Juleen, additional, Thomis, Martine, additional, and Loos, Ruth, additional

Published
2021
Full Text
View/download PDF

41. Effects of Nigella sativa supplementation on blood concentration and mRNA expression of TNF- α , PPAR- γ and adiponectin, as major adipogenesis-related markers, in obese and overweight women: a crossover, randomised-controlled trial.

Author

Razmpoosh, Elham, Safi, Sara, Nadjarzadeh, Azadeh, Salehi-Abargouei, Amin, Mazaheri, Mahta, Mirmiran, Parvin, and Meyre, David

Subjects
PHYTOTHERAPY, OBESITY, BLOOD, BODY weight, CELL receptors, PEROXISOME proliferator-activated receptors, WOMEN, DIETARY supplements, TREATMENT effectiveness, RANDOMIZED controlled trials, GENE expression, MESSENGER RNA, TUMOR necrosis factors, ADIPONECTIN, RESEARCH funding, PLANT extracts, STATISTICAL sampling, CROSSOVER trials, PHARMACODYNAMICS
Abstract

Adipocyte expansion through adipogenesis can offset the adverse metabolic effects of obesity. Nigella sativa (NS) (black seed) oil is shown to have therapeutic features in the management of obesity. NS oil might have beneficial changes in obese populations through mediating serum levels of adipogenesis-related parameters and relative transcriptional gene–diet interactions (nutrigenomics), though no previous studies assessed this mechanism in overweight/obese participants. This study assessed the effects of NS oil supplements on blood concentration and mRNA expression levels of TNF- α , PPAR- γ and serum adiponectin and expression of AdipoR1 , as major adipogenesis and obesity-related parameters, in overweight/obese women using a cross-over design. Eligible women were randomised to receive either NS oil supplements (2000 mg/d) or placebo. Two periods of interventions (8 weeks in each) were cross-changed by a 4-week washout period. An individualised diet plan without calorie deficits was given to participants to match their energy/macronutrient intakes. The Pkcross procedure and intention-to-treat analysis were performed using Stata. Cohen's d(d) was estimated to measure the magnitude of the effects. Forty-six participants were included. NS oil capsules reduced transcription levels ((d = –2·31), P < 0·001) and blood concentrations of TNF- α ((d = –0·29), P < 0·001). AdipoR1 expression (d = 2·24, P < 0·001) and serum adiponectin (d = 0·88, P < 0·001) showed a significant augmentation with a medium-high effect size, as did gene expression (d = 0·69, P < 0·001) and serum levels of PPAR- γ (d = 0·97, P < 0·001). There was a moderate but significant decrease in body weight (d = 0·6, P < 0·001). The present beneficial findings would provide strong information for future nutrigenomics/clinical trial studies assessing the role of NS in the management of obesity and other comorbidities. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

42. Low-frequency Coding Variants Associated With Body Mass Index Affect the Success of Bariatric Surgery

Author

Antoine, Darlène, primary, Guéant-Rodriguez, Rosa-Maria, additional, Chèvre, Jean-Claude, additional, Hergalant, Sébastien, additional, Sharma, Tanmay, additional, Li, Zhen, additional, Rouyer, Pierre, additional, Chery, Céline, additional, Halvick, Sarah, additional, Bui, Catherine, additional, Oussalah, Abderrahim, additional, Ziegler, Olivier, additional, Quilliot, Didier, additional, Brunaud, Laurent, additional, Guéant, Jean-Louis, additional, and Meyre, David, additional

Published
2021
Full Text
View/download PDF

43. Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

Author

Nead, Kevin T., Li, Aihua, Wehner, Mackenzie R., Neupane, Binod, Gustafsson, Stefan, Butterworth, Adam, Engert, James C., Davis, A. Darlene, Hegele, Robert A., Miller, Ruby, den Hoed, Marcel, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Wareham, Nick, Edwards, Todd L., Hallmans, Göran, Varga, Tibor V., Kardia, Sharon L. R., Smith, Jennifer A., Zhao, Wei, Faul, Jessica D., Weir, David, Mi, Jie, Xi, Bo, Quinteros, Samuel Canizales, Cooper, Cyrus, Sayer, Avan Aihie, Jameson, Karen, Grøntved, Anders, Fornage, Myriam, Sidney, Stephen, Hanis, Craig L., Highland, Heather M., Häring, Hans-Ulrich, Heni, Martin, Lasky-Su, Jessica, Weiss, Scott T., Gerhard, Glenn S., Still, Christopher, Melka, Melkaey M., Pausova, Zdenka, Paus, Tomáš, Grant, Struan F. A., Hakonarson, Hakon, Price, R. Arlen, Wang, Kai, Scherag, Andre, Hebebrand, Johannes, Hinney, Anke, Franks, Paul W., Frayling, Timothy M., McCarthy, Mark I., Hirschhorn, Joel N., Loos, Ruth J., Ingelsson, Erik, Gerstein, Hertzel C., Yusuf, Salim, Beyene, Joseph, Anand, Sonia S., and Meyre, David

Published
2015
Full Text
View/download PDF

45. Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi--like features

Author

Bonnefond, Amelie, Raimondo, Anne, Stutzmann, Fanny, Ghoussaini, Maya, Ramachandrappa, Shwetha, Bersten, David C., Durand, Emmanuelle, Vatin, Vincent, Balkau, Beverley, Lantieri, Olivier, Raverdy, Violeta, Pattou, Francois, Van Hul, Wim, Van Gaal, Luc, Peet, Daniel J., Weill, Jacques, Miller, Jennifer L., Horber, Fritz, Goldstone, Anthony P., Driscoll, Daniel J., Bruning, John B., Meyre, David, Whitelaw, Murray L., and Froguel, Philippe

Subjects
Gene mutations -- Observations, Obesity in children -- Genetic aspects, Prader-Willi syndrome -- Genetic aspects -- Complications and side effects -- Physiological aspects, Health care industry
Abstract

Sim1 haploinsufficiency in mice induces hyperphagic obesity and developmental abnormalities of the brain. In humans, abnormalities in chromosome 6q16, a region that includes SIM1, were reported in obese children with [...]

Published
2013
Full Text
View/download PDF

49. Estimation of Newborn Risk for Child or Adolescent Obesity

Author

Morandi, Anita, primary, Meyre, David, additional, Lobbens, Stéphane, additional, Kleinman, Ken, additional, Kaakinen, Marika, additional, Rifas-Shiman, Sheryl, additional, Vatin, Vincent, additional, Gaget, Stefan, additional, Pouta, Anneli, additional, Hartikainen, Anna-Liisa, additional, Laitinen, Jaana, additional, Ruokonen, Aimo, additional, Das, Shikta, additional, Khan, Anokhi, additional, Elliott, Paul, additional, Maffeis, Claudio, additional, Gillman, Matthew, additional, Järvelin, Marjo-Riitta, additional, and Froguel, Philippe, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results