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44 results on '"Meyfour, Anna"'

24. Clinical Perspective: Antibody-Drug Conjugates (ADCs) for the Treatment of HER2-Positive Breast Cancer

Author

Najminejad, Zohreh, primary, Dehghani, Fatemeh, additional, Mirzaei, Yousef, additional, Mer, Ali Hussein, additional, Saghi, Seyyed Amirreza, additional, Abdolvahab, Mohadeseh Haji, additional, Bagheri, Nader, additional, Meyfour, Anna, additional, Jafari, Ameneh, additional, Jahandideh, Saeed, additional, Gharibi, Tohid, additional, Amirkhani, Zahra, additional, Delam, Hamed, additional, Mashatan, Noushin, additional, Shahsavarani, Hosein, additional, and Abdollahpour‐Alitappeh, Meghdad, additional

Published
2023
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28. Additional file 1 of Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysis

Author

Maleknia, Samaneh, Tavassolifar, Mohammad Javad, Mottaghitalab, Faezeh, Zali, Mohammad Reza, and Meyfour, Anna

Abstract

Additional file 1: Fig. S1. PCA plots for batch effect removal using ComBat-seq in Whole Blood samples: The PCA plots show the samples of RNA-seq datasets before (A) and after (B) batch effect removal. Fig. S2. PCA plots for batch effect removal using ComBat-seq in nasopharyngeal samples: The PCA plots show the samples of RNA-seq datasets before (A) and after (B) batch effect removal.

Published
2022
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29. Iran’s Contribution to Human Proteomic Research

Author

Meyfour, Anna, Hosseini, Mahya, Sobhanian, Hamid, and Pahlavan, Sara

Subjects
Proteomics, proteomix, Cellular and Molecular Biology, Stem Cell, Infertility, lcsh:R, lcsh:Medicine, lcsh:Q, Review Article, Iran, lcsh:Science
Abstract

Proteomics is a powerful approach to study the whole set of proteins expressed in an organism, organ, tissue or cell resulting in valuable information on physiological or pathological state of a biological system. High throughput proteomic data facilitated the understanding of various biological systems with respect to normal and pathological conditions particularly in the instances of human clinical manifestations. The important role of proteins as the functional gene products encouraged scientists to apply this technology to gain a better understanding of extremely complex biological systems. In last two decades, several proteomics teams have been gradually formed in Iran. In this review, we highlight the most important findings of proteomic research groups in Iran at various areas of stem cells, Y chromosome, infertility, infectious disease and biomarker discovery.

Published
2019

32. Contribution of NOTCH signaling pathway along with TNF-α in the intestinal inflammation of ulcerative colitis

Author

Ghorbaninejad, Mahsa, Heydari, Raheleh, Mohammadi, Parvaneh, Shahrokh, Shabnam, Haghazali, Mehrdad, Khanabadi, Binazir, and Meyfour, Anna

Subjects
Ulcerative colitis, TNF-α, HES1, Original Article, NOTCH signaling
Abstract

Aim: The aim of this study was to determine gene expression levels of TNF-α, NOTCH1, and HES1 in patients with UC. Background: Intestinal inflammation and epithelial injury are the leading actors of inflammatory bowel disease (IBD), causing an excessive expression of pro-inflammatory cytokines such as TNF-α. Also, target genes of NOTCH signaling are involved in the regulation of intestinal homeostasis. Previous studies have demonstrated that TNF-α increases in ulcerative colitis (UC) patients, but the relationship between TNF-α and NOTCH signaling pathway in UC etiopathology needs further study. Methods: Twelve active UC patients and twelve healthy controls were enrolled in this study. RNA was extracted and the mRNA expression levels of TNF-α, NOTCH1, and HES1 were examined using real-time PCR analyses. Further, transcriptome data deposited in Gene Expression Omnibus (GEO) database were analyzed to detect the differential expression of TNF superfamily and NOTCH1 gene in IBD patients. Finally, the interaction of TNF-α and NOTCH signaling was obtained from The SIGnaling Network Open Resource 2.0 (SIGNOR 2.0) database. Results: The transcription levels of TNF-α, NOTCH1, and HES1 genes were significantly elevated in UC patients compared with control (p < 0.05). In addition, GEO results confirmed our expression results. SIGNOR analysis showed that TNF-α interacts with NOTCH signaling components. Conclusion: Based on our data, we observed that NOTCH1 and HES1 in co-operation of TNF-α, may play an important role in pathogenesis of UC. The members of NOTCH signaling pathway can be ideal candidates to target the therapy of IBD.

Published
2019

33. Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s Disease

Author

Abyadeh, Morteza, primary, Gupta, Vivek, primary, Gupta, Veer, primary, Chitranshi, Nitin, primary, Wu, Yunqi, primary, Amirkhani, Ardeshir, primary, Meyfour, Anna, primary, Sheriff, Samran, primary, Shen, Ting, primary, Dhiman, Kunal, primary, Salekdeh, Ghasem H., primary, Haynes, Paul A., primary, Graham, Stuart L., primary, and Mirzaei, Mehdi, primary

Published
2021
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40. Rabies virus matrix protein targets host actin cytoskeleton: a protein–protein interaction analysis.

Author

Zandi, Fatemeh, Khalaj, Vahid, Goshadrou, Fatemeh, Meyfour, Anna, Gholami, Alireza, Enayati, Somayeh, Mehranfar, Mahsa, Rahmati, Saman, Kheiri, Elmira Vadaye, Badie, Hamid Gholamipour, and Vaziri, Behrouz

Subjects
EXTRACELLULAR matrix proteins, VIRAL proteins, RABIES virus, PROTEIN-protein interactions, CYTOSKELETON, MICROFILAMENT proteins, BRAIN stem
Abstract

Multifunctional matrix protein (M) of rabies virus (RABV) plays essential roles in the pathogenesis of rabies infection. Identification of M protein interacting partners in target hosts could help to elucidate the biological pathways and molecular mechanisms involved in the pathogenesis of this virus. In this study, two-dimensional Far-western blotting (2D-Far-WB) technique was applied to find possible matrix protein partners in the rat brainstem. Recombinant RABV M was expressed in Pichia pastoris and was partially purified. Subsequently, 2D-Far-WB-determined six rat brainstem proteins interacted with recombinant M proteins that were identified by mass spectrometry. Functional annotation by gene ontology analysis determined these proteins were involved in the regulation of synaptic transmission processes, metabolic process and cell morphogenesis–cytoskeleton organization. The interaction of viral M protein with selected host proteins in mouse Neuro-2a cells infected with RABV was verified by super-resolution confocal microscopy. Molecular docking simulations also demonstrated the formation of RABV M complexes. However, further confirmation with co-immunoprecipitation was only successful for M-actin cytoplasmic 1 interaction. Our study revealed actin cytoplasmic 1 as a binding partner of M protein, which might have important role(s) in rabies pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Stress-Induced Proteomic Changes in the Hippocampus of Pregnant Wistar Rats.

Author

Ardekani, Ali M., Maghsudi, Nader, Meyfour, Anna, Ghasemi, Rasool, Lakpour, Niknam, Nooshinfar, Elahe, and Ghaempanah, Zahra

Subjects
*ANALYSIS of variance, *ANIMAL experimentation, *ELECTROPHORESIS, *ENZYME-linked immunosorbent assay, *PHARMACEUTICAL gels, *HIPPOCAMPUS (Brain), *RATS, *STATISTICS, *PSYCHOLOGICAL stress, *T-test (Statistics), *PROTEOMICS, *DATA analysis, *RANDOMIZED controlled trials
Abstract

Stress is a threatening factor that all living organisms encounter throughout life. Depending on the type of stress, there are several mechanisms for keeping body homeostasis to minimize stress effects. Brain is an organ which shows high sensitivity to stress conditions. Although many studies have shown induced- stress effects on rat embryos, little is known about the mechanisms involved in coping with stress by female rats during pregnancy. In the present study, restraint stress method was applied because this technique has been widely used in animal models to induce both psychological and physical stress. Restraint stress was applied in regular sessions (1 and 3 hrs) in two groups of 6 pregnant Wistar rats and similar number of animals was used as control group receiving no stress. ACTH and corticosterone levels in plasma samples were shown to increase in response to stress treatments. On the last day of pregnancy, rat hippocampus from the brain of each animal in all three groups was removed and analyzed using 2 Dimensional Gel Electrophoresis (2DE) technique. Using Image Master Software, approximately 2000 proteins were detected in the 2D gels analyzed, among which 34 proteins exhibited differential expression. These results indicate that the proteome patterns from the hippocampus of pregnant rats subjected to 1 and 3 hr of stress differs significantly from the control (unstressed) group. Future mass spectrometry identification of the 34 protein spots discovered in this study should allow a more precise understanding of molecules and cellular pathways involved in stress-induced responses during pregnancy. [ABSTRACT FROM AUTHOR]

Published
2011

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