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28 results on '"Meyer, William L."'

2. Cardiac and skeletal muscle adaptations to training in systemic hypertension and effect of beta blockade (metoprolol or propranolol)

Author

Ades, Philip A., Gunther, Peter G.S., Meyer, William L., Gibson, Thomas C., Maddalena, John, and Orfeo, Thomas

Subjects
Exercise -- Physiological aspects, Metoprolol -- Evaluation, Hypertension -- Drug therapy, Adrenergic beta blockers -- Evaluation, Propranolol hydrochloride -- Evaluation, Health
Abstract

TABULAR DATA OMITTED Cardiovascular and peripheral adaptations to an aerobic conditioning program were studied in 30 hypertensive adults taking either Placebo',[beta][.sub.1]-selective [beta]-adrenergic blocker (metoprdol) or [beta][.sub.1]-nonselective [beta]-adrenergic blocker (propranoid). The placebo group increased aerobic capacity (V0[.sub.2]max) 24% (p (Am J Cardiol 1990;66:591-596), Beta-adrenergic blocking agents prevent the activation of beta-adrenergic receptors, which are specialized cell membrane proteins that trigger specific cell processes such as heart rate and contraction. However, these drugs have been shown to decrease the capacity for exercise and to diminish conditioning response to aerobic exercise in healthy individuals. Studies have also shown that exercise conditioning normally increases aerobic capacity and decreases resting blood pressure in patients with high blood pressure (hypertension). Although beta-adrenergic blocking agents are commonly used to treat hypertension, the effects of these drugs on exercise conditioning in hypertensive patients are not known. However, a drug that selectively blocks the beta-1-type receptors may not affect the beta-2 receptor-mediated dilation of blood vessels during exercise. Hence, the effects of the beta-1 receptor blocking agent metoprolol and the nonspecific beta receptor blocker propranolol on exercise conditioning response were assessed in 30 patients with hypertension. Aerobic conditioning resulted in a 24 percent increase in aerobic capacity, reduced blood pressure, and decreased systemic resistance (the force against which blood flows in the peripheral circulation), in patients who were not treated with beta blocking agents. Aerobic capacity was increased by 8 percent and blood pressure decreased in patients treated with metoprolol. Patients treated with propranolol had no increase in aerobic capacity, no reduction in blood pressure, and no adaptation of the heart and blood vessels to exercise training. These findings show that selective beta-1 blocking agents such as metoprolol and nonspecific beta blocking agents such as propranolol can diminish the exercise conditioning effects in hypertensive patients to varying degrees. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

5. Tax-exempt financing of housing for the elderly in Georgia.

Author

Pannell, Robert D. and Meyer, William L.

Subjects
Nursing homes -- Finance, Exemption (Law) -- Innovations, Aged, Public housing -- Finance, Georgia Residential Care Facilities for the Elderly Authorities Act
Published
1980

6. Noise Suppression in Jet Inlets.

Author

GEORGIA INST OF TECH ATLANTA SCHOOL OF AEROSPACE ENGINEERING, Zinn,Ben T, Meyer,William L, Daniel,Brady R, GEORGIA INST OF TECH ATLANTA SCHOOL OF AEROSPACE ENGINEERING, Zinn,Ben T, Meyer,William L, and Daniel,Brady R

Abstract

This research program was concerned with the development of an analytical technique, based on an integral representation of the external solutions of the Helmholtz equation, for the prediction of the sound radiated from complicated, acoustically lined, axisymmetric bodies having complex sound sources. The purpose of this research program was to generate efficient computer codes for the prediction of the sound radiated from acoustically lined jet engine inlets. In the experimental tests two geometrical configurations were studied, a straight duct and a jet engine inlet. Both of these configurations were tested with hard walls and the straight duct was tested with an acoustic liner consisting of a matrix of Helmholtz resonators. It was found that very good agreement was obtained for the hard walled configurations while there were some discrepancies with the lined wall case. It is conjectured that this discrepancy in some of the lined wall results is mainly due to the particular liner theory used to calculate the effective admittance of the liner., See also Rept. Nos. AFOSR-TR-78-0696 AD-A054 173 and AFOSR-TR-79-0614, AD-A069 787.

Published
1980

7. Noise Suppression in Jet Inlets.

Author

GEORGIA INST OF TECH ATLANTA SCHOOL OF AEROSPACE ENGINEERING, Zinn,Ben, Meyer,William L, Bell,William A, GEORGIA INST OF TECH ATLANTA SCHOOL OF AEROSPACE ENGINEERING, Zinn,Ben, Meyer,William L, and Bell,William A

Abstract

This report summarizes the work performed during the first year of a research effort to determine the sound fields associated with jet engine inlet configurations. A solution approach for axisymmetric bodies based upon the integral formulation of the wave equation has been developed. This solution approach circumvents the uniqueness problems which normally occur at certain frequencies when 'straight forward' solutions of the integral equation are obtained. A numerical method and a computer program for solving for the acoustic field associated with general inlet configurations and boundary conditions have also been developed. To evaluate the numerical method, computed and exact results are compared for a sphere and a finite length cylinder. For continuous boundary conditions, the agreement is within ten per cent over a range of nondimensional frequencies from one to ten. For discontinuous boundary conditions, the numerical errors increased by a factor of two. This report presents results for a given inlet configuration and the computed and exact solutions are shown to agree to within ten per cent over the nondimensional frequency range from one to ten. (Author)

Published
1978

28. Acute kidney injury, hyperbilirubinemia, and ischemic skin necrosis due to massive sulindac overdose.

Author

Vaughn JL, Shah KV, Ghossein MM, Meyer WL, and Kirkpatrick RB

Subjects
Acute Kidney Injury therapy, Bipolar Disorder complications, Fluid Therapy, Humans, Ischemia, Male, Necrosis, Renal Dialysis, Resuscitation, Skin blood supply, Skin Diseases pathology, Suicide, Attempted, Young Adult, Acute Kidney Injury chemically induced, Anti-Inflammatory Agents, Non-Steroidal poisoning, Drug Overdose, Hyperbilirubinemia chemically induced, Skin Diseases chemically induced, Sulindac poisoning
Abstract

Sulindac is a long-acting nonsteroidal anti-inflammatory drug (NSAID) widely used for the management of osteoarthritis, rheumatoid arthritis, ankylosing sponydlitis, and acute gouty arthritis. Reports of sulindac toxicity in the literature are rare. We report the case of a 22-year old male with a history of bipolar disorder who was brought to the emergency department after ingesting approximately 15 g of sulindac in a suicide attempt. He was found to have acute kidney injury and hyperbilirubinemia. Despite aggressive fluid resuscitation, his renal function progressively worsened requiring the initiation of hemodialysis. Ten days following ingestion of sulindac, he began to develop ischemic skin changes with a gangrenous appearance in his hands and feet. He continued to receive supportive treatment, and his acute kidney injury, hyperbillirubinemia, and ischemic skin necrosis eventually resolved. Clinicians should be aware of this long-acting NSAID and its ability to cause prolonged multisystem organ dysfunction.

Published
2015
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