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2. Resolving spatial response heterogeneity in glioblastoma

Author

Ziegenfeuter, Julian, Delbridge, Claire, Bernhardt, Denise, Gempt, Jens, Schmidt-Graf, Friederike, Hedderich, Dennis, Griessmair, Michael, Thomas, Marie, Meyer, Hanno S, Zimmer, Claus, Meyer, Bernhard, Combs, Stephanie E, Yakushev, Igor, Metz, Marie-Christin, and Wiestler, Benedikt

Published
2024
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3. Prevention of Surgical Site Infections in Spine Surgery: An International Survey of Clinical Practices Among Expert Spine Surgeons.

Author

Sekhon, Lali, Shaffrey, Christopher, Smith, Justin, Hart, Robert, Kim, Han, Wang, Jeffrey, Ha, Yoon, Kwan, Kenny, Hai, Yong, Valacco, Marcelo, Falavigna, Asdrubal, Taboada, Néstor, Guiroy, Alfredo, Emmerich, Juan, Meyer, Bernhard, Kandziora, Frank, Thomé, Claudius, Loibl, Markus, Peul, Wilco, Gasbarrini, Alessandro, Obeid, Ibrahim, Gehrchen, Martin, Trampuz, Andrej, Vajkoczy, Peter, Onken, Julia, Tkatschenko, Dimitri, Hansen, Sonja, Koch, Julia, Ames, Christopher, Fehlings, Michael, and Berven, Sigurd

Abstract

STUDY DESIGN: Questionnaire-based survey. OBJECTIVES: Surgical site infection (SSI) is a common complication in spine surgery but universal guidelines for SSI prevention are lacking. The objectives of this study are to depict a global status quo on implemented prevention strategies in spine surgery, common themes of practice and determine key areas for future research. METHODS: An 80-item survey was distributed among spine surgeons worldwide via email. The questionnaire was designed and approved by an International Consensus Group on spine SSI. Consensus was defined as more than 60% of participants agreeing to a specific prevention strategy. RESULTS: Four hundred seventy-two surgeons participated in the survey. Screening for Staphylococcus aureus (SA) is not common, whereas preoperative decolonization is performed in almost half of all hospitals. Body mass index (BMI) was not important for surgery planning. In contrast, elevated HbA1c level and hypoalbuminemia were often considered as reasons to postpone surgery. Cefazoline is the common drug for antimicrobial prophylaxis. Alcohol-based chlorhexidine is mainly used for skin disinfection. Double-gloving, wound irrigation, and tissue-conserving surgical techniques are routine in the operating room (OR). Local antibiotic administration is not common. Wound closure techniques and postoperative wound dressing routines vary greatly between the participating institutions. CONCLUSIONS: With this study we provide an international overview on the heterogeneity of SSI prevention strategies in spine surgery. We demonstrated a large heterogeneity for pre-, peri- and postoperative measures to prevent SSI. Our data illustrated the need for developing universal guidelines and for testing areas of controversy in prospective clinical trials.

Published
2023

9. Treatment outcome of IDH1/2 wildtype CNS WHO grade 4 glioma histologically diagnosed as WHO grade II or III astrocytomas

Author

Keric, Naureen, Krenzlin, Harald, Kalasauskas, Darius, Freyschlag, Christian F., Schnell, Oliver, Misch, Martin, von der Brelie, Christian, Gempt, Jens, Krigers, Aleksandrs, Wagner, Arthur, Lange, Felipa, Mielke, Dorothee, Sommer, Clemens, Brockmann, Marc A., Meyer, Bernhard, Rohde, Veit, Vajkoczy, Peter, Beck, Jürgen, Thomé, Claudius, and Ringel, Florian

Published
2024
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10. Mobile Health in Oncology: A Patient Survey About App-Assisted Cancer Care

Author

Kessel, Kerstin Anne, Vogel, Marco ME, Kessel, Carmen, Bier, Henning, Biedermann, Tilo, Friess, Helmut, Herschbach, Peter, von Eisenhart-Rothe, Rüdiger, Meyer, Bernhard, Kiechle, Marion, Keller, Ulrich, Peschel, Christian, Schmid, Roland M, and Combs, Stephanie E

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundIn the last decade, the health care sector has been enriched by numerous innovations such as apps and connected devices that assist users in weight reduction and diabetes management. However, only a few native apps in the oncological context exist, which support patients during treatment and aftercare. ObjectiveThe objective of this study was to analyze patients’ acceptance regarding app use and to investigate the functions of an oncological app that are most required, and the primary reasons for patients to refuse app-assisted cancer care. MethodsWe designed and conducted a survey with 23 questions, inquiring patients about their technical knowledge and equipment, as well as the possible advantages and disadvantages, data transfer, and general functionality of an app. ResultsA total of 375 patients participated; the participation rate was 60.7% (375/618). Gender distribution was about 3:4 (female:male) with a median age of 59 years (range 18-92 years). Whereas 69.6% (261/375) of patients used mobile devices, 16.3% (61/375) did not own one, and 9.1% (34/375) only used a personal computer (PC). About half of the patients rated their usability skills as very good and good (18.9% 71/375; 35.2% 132/375), 23.5% (88/375) described their skills as intermediate, and 14.4% (54/375) as bad. Of all patients, 182 (48.5%, 182/375) were willing to send data to their treating clinic via an app, that is, to a server (61.0% 111/182) or as email (33.5%, 61/182). About two-thirds (68.7%, 125/182) believed that additional and regularly sent data would be an ideal complement to the standard follow-up procedure. Additionally, 86.8% (158/182) wished to be contacted by a physician when entered data showed irregularities. Because of lack of skills (34.4%, 56/163), concerns about the use of data (35.0%, 57/163), lack of capable devices (25.8%, 42/163), and the wish for personal contact with the treating physician (47.2%, 77/163), a total of 163 (43.5%, 163/375) patients refused to use an app. Pearson correlation showed a significant but mild relationship between age and app use (P=.03, r=−.12), favoring younger age; male gender correlated as well (P=.04; r=−.11). ConclusionsThe results show that the introduction of mobile apps needs to follow different strategies depending on the patients’ attitude. Age and gender seem to be the strongest predictive factors. For oncology patients, our survey showed that about half of the patients were willing to send data via an app supporting their treatment. In the future, clinical data such as quality of life and treatment satisfaction recorded by mobile health (mHealth) devices could be used to evaluate and improve therapy workflow. Furthermore, apps could support classical visits, document adverse effects, and remind patients of treatment dates or drug intake.

Published
2017
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15. Hygienic safety of alcohol-based hand disinfectants and skin antiseptics

Author

Steinhauer, Katrin, Meyer, Bernhard, Ostermeyer, Christiane, Rödger, Hans-Joachim, and Hintzpeter, Matthias

Subjects
hand disinfectants, skin antiseptics, spores, hygienic safety, contamination, alcohol, Medicine, Public aspects of medicine, RA1-1270, Microbiology, QR1-502
Abstract

[english] Purpose: The aim of this study was to evaluate the overall risk of hand disinfectants and skin antiseptics to become contaminated with bacterial spores throughout the production process and the subsequent in-use period, hence posing a public health risk. Methods: Microbiological assessment of primary packaging material was carried out and long-term survival of bacterial spores in alcohol was assessed using sporulated ATCC 6633 as a standard. In-use contamination of alcohol-based formulations was tested by repeated use over 12 months under practical conditions and microbiological and physico-chemical data were determined.Results: Among 625 containers analyzed, 542 did not yield any microbial growth. Median colony count for aerobic spore-forming bacteria was 0.2 cfu/10 ml container content. No anaerobic spore-forming bacteria were detected. Additionally, long-term survival of bacterial spores in aliphatic C2–C3 alcohols revealed 1-propanol to reduce the number of spores most effectively, with 2-propanol and ethanol having a somewhat less pronounced impact. In-use tests did not detect any microbial contamination or change in the physicochemical properties of the tested products over 12 months. Conclusions: Our data reveals that state-of-the-art production processes of alcohol-based hand rubs and antiseptics can be regarded safe. Primary packaging material and use were not found to pose a significant contamination risk as far as bacterial spores are concerned. Based on the data from this study, a microbial limit of

Published
2013
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17. Association of Fluid Balance and Hemoglobin Decline With Neurological Outcome After Aneurysmal Subarachnoid Hemorrhage

Author

Truckenmueller, Peter, Wolf, Stefan, Wasilewski, David, Vajkoczy, Peter, Früh, Anton, Baro, Norbert, Bauer, Miriam, Barner, Christoph, Dengler, Nora F., von Dincklage, Falk, Finger, Tobias, Francis, Roland, Hotter, Benjamin, Hunsicker, Oliver, Jussen, Daniel, Jüttler, Eric, Pohrt, Anne, Salih, Farid, Schaumann, Andreas, Witsch, Jens, Nagel, Christoph, Lemcke, Johannes, Meier, Ullrich, Podlesik, Dino, Schackert, Gabriele, Juratli, Tareq A., Huttner, Hagen, Schwab, Stefan, Staykov, Dimitre, Hagedorn, Sabine, Müller, Daniela, Müller, Oliver, Sarge, Robert, Sure, Ulrich, Bardutzky, Jürgen, Niesen, Wolf-Dirk, Lange, Katharina, Malinova, Vesna, Mielke, Dorothee, Rohde, Veit, Päsler, Dennis, Reinhardt, Stephanie, Schroeder, Henry W.S., Czorlich, Patrick, Regelsberger, Jan, Sauvigny, Thomas, Westphal, Manfred, Ehlert, Angelika, Gremmer, Rudolf, Beyer, Christian, Beyer, Desiree, Huthmann, Alexandra, Kerz, Thomas, Landscheidt, Julia, Schürer, Ludwig, Schul, David B., Meyer, Bernhard, Ryang, Yu-Mi, Toeroek, Elisabeth, Wostrack, Maria, Arouk, Wasim, Al-Jehani, Hosam, Fritsch, Michael, Al-Jehani, Hosam, Alturk, Abdulrahman Y., Sinclair, David B., Beck, Jürgen, Fung, Christian, Soell, Nicole, Engel, Doortje C., Hildebrandt, Gerhard, Huscher, Karen, Lange, Heidrun, Hutchinson, Peter, and Tseng, Ming-Yuan

Published
2024
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22. Impact of the SARS-CoV-2 pandemic on the survival of patients with high-grade glioma and best practice recommendations

Author

Vogel, Marco M. E., Wagner, Arthur, Gempt, Jens, Krenzlin, Harald, Zeyen, Thomas, Drexler, Richard, Voss, Martin, Nettekoven, Charlotte, Abboud, Tammam, Mielke, Dorothee, Rohde, Veit, Timmer, Marco, Goldbrunner, Roland, Steinbach, Joachim P., Dührsen, Lasse, Westphal, Manfred, Herrlinger, Ulrich, Ringel, Florian, Meyer, Bernhard, and Combs, Stephanie E.

Published
2023
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25. Functional connectivity signatures of major depressive disorder: machine learning analysis of two multicenter neuroimaging studies

Author

Gallo, Selene, El-Gazzar, Ahmed, Zhutovsky, Paul, Thomas, Rajat M., Javaheripour, Nooshin, Li, Meng, Bartova, Lucie, Bathula, Deepti, Dannlowski, Udo, Davey, Christopher, Frodl, Thomas, Gotlib, Ian, Grimm, Simone, Grotegerd, Dominik, Hahn, Tim, Hamilton, Paul J., Harrison, Ben J., Jansen, Andreas, Kircher, Tilo, Meyer, Bernhard, Nenadić, Igor, Olbrich, Sebastian, Paul, Elisabeth, Pezawas, Lukas, Sacchet, Matthew D., Sämann, Philipp, Wagner, Gerd, Walter, Henrik, Walter, Martin, and van Wingen, Guido

Published
2023
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31. Expertise in surgical neuro-oncology. Results of a survey by the EANS neuro-oncology section

Author

Agrawal, Rachit, Albano, Luigi, Alexiou, George A., Ali, Amanj, Al-Mahfoudh, Rafid, Amoo, Michael, Anagnostopoulos, Christos, Bamps, Sven, Bandyopadhyay, Soham, Barone, Damiano G., Barone, Fabio, Barrit, Sami, Behling, Felix, Blaga, Alin, Boukas, Alexandros, Brennan, Paul, Butenschoen, Vicki M., Campello, Mauro, Cara, Areda, Chibbaro, Salvatore, Chrenko, Robert, Cifre Serra, Pere J., Clusmann, Hans, Corell, Alba, Cornelius, Jan F., D'Andrea, Marcello, Demetriades, Andreas K., De Vleeschouwer, Steven, Drexler, Richard, Duerinck, Johnny, Fanarjyan, Ruben V., Fernandez-Coello, Alejandro, Fountas, Kostas, Freiman, Thomas M., Gadzhiagaev, Vadim, Georgiopoulos, Miltiadis, Gilis, Nathalie, Golubovic, Jagos, Lippi Fernandes, Eric Goulin, Grasso, Giovanni, Guerrini, Francesco, Gulsuna, Beste, Hill, Ciaran S., Höhne, Julius, Holling, Markus, Iarmoliuk, Ievgenii, Ioan-Alexandru, Florian, Ius, Tamara, Jacikevicius, Kestutis, Jakola, Asgeir S., Jakubowski, Paweł, Kalantzis, Georgios, Karabatsou, Konstantina, Kirollos, Ramez, König, Ralph, Kozyrev, Danil A., Krex, Dietmar, Ladisich, Barbara, Lau, Ruth, Lizunou, Yauhen, Lombard, Arnaud, Low, Hu Liang, Alves, José Luís, Maghrabi, Yazid, Mammi, Marco, Marji, Ala, Massimi, Luca, Mavridis, Ioannis, McLean, Aaron Lawson, Lawson McLean, Anna C., Meyer, Bernhard, Mohme, Malte, Branco, Pedro Moura, Müther, Michael, Musleh, Issam, Nasiri, Danial, Navarro, Ramon, Omerhodzic, Ibrahim, Oppong, Marvin Darkwah, Paidakakos, Nikolaos A., Pantera, Zoi, Patel, Mohammed A., Pawlowski, Mateusz, Petridis, Athanasios, Praeger, Adrian J., Price, Stephen, Ricklefs, Franz, Rigante, Luigi, Ringel, Florian, Robe, Pierre A., Rössler, Karl, Sá-Marta, Eduarda, Sanmillan, Jose L., Scerrati, Alba, Schneider, Matthias, Schroeder, Henry W.S., Schwake, Michael, Shoaib, Mohamed, Sirbu, Octavian Mihai, Sistiaga, Iñigo L., Skajster, Tomasz J., Sliauzys, Albertas, Sokotukhin, Vitaly, Soleman, Jehuda, Stoecklein, Veit M., Suero Molina, Eric, Świątnicki, Wojciech, Syrmos, Νikolaos, Taddei, Graziano, Taher, Avin, Tamarit, Martin, Laan, Mark ter, Theocharous, Theocharis, Thijs, Dieter, Trakolis, Leonidas, Truffelli, Monica, Weiss, Miriam, Uhl, Eberhard, Valentini, Laura Grazia, Vanhauwaert, Dimitri, Zebian, Bassel, Zivkovic, Bojana, Zoli, Matteo, Gousias, K., Hoyer, A., Mazurczyk, L.A., Bartek, J., Jr., Bruneau, M., Celtikci, E., Foroglou, N., Freyschlag, C., Grossman, R., Jungk, C., Metellus, P., Netuka, D., Rola, R., Schucht, P., Senft, C., Signorelli, F., Vincent, A.J.P.E., and Simon, M.

Published
2024
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35. Identifying core MRI sequences for reliable automatic brain metastasis segmentation

Author

Buchner, Josef A, Peeken, Jan C, Etzel, Lucas, Ezhov, Ivan, Mayinger, Michael, Christ, Sebastian M, Brunner, Thomas B, Wittig, Andrea, Menze, Bjoern H, Zimmer, Claus, Meyer, Bernhard, Guckenberger, Matthias, Andratschke, Nicolaus, El Shafie, Rami A, Debus, Jürgen, Rogers, Susanne, Riesterer, Oliver, Schulze, Katrin, Feldmann, Horst J, Blanck, Oliver, Zamboglou, Constantinos, Ferentinos, Konstantinos, Bilger, Angelika, Grosu, Anca L, Wolff, Robert, Kirschke, Jan S, Eitz, Kerstin A, Combs, Stephanie E, Bernhardt, Denise, Rueckert, Daniel, Piraud, Marie, Wiestler, Benedikt, and Kofler, Florian

Published
2023
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39. Association of bone mineral density with reoperation rate following instrumented lumbar spinal fusion

Author

Löffler, Maximilian T., Loreck, Niklas, Kaesmacher, Johannes, Zibold, Felix, Shiban, Ehab, Rienmüller, Anna, Vazan, Martin, Meyer, Bernhard, Ryang, Yu-Mi, and Kirschke, Jan S.

Subjects
Quantitative Biology - Tissues and Organs
Abstract

Low bone mineral density (BMD) is believed to influence the outcome of instrumented spinal surgery and can lead to reoperation. Purpose of this observational and case-control study was to investigate the association of BMD with the risk of reoperation following instrumented lumbar spinal fusion (LSF). For the observational study, 81 patients were included who received LSF with and without augmentation. For the case-control study, 18 patients who had reoperation following LSF were matched to 26 patients who did not have reoperation (matched by sex, age +/- 5 years, fused levels and PMMA-augmentation). Opportunistic BMD screening was performed in perioperative CT scans using asynchronous calibration. Mean BMD was compared between patients with and without reoperation in augmented and non-augmented surgeries. In the observational study, prevalence of osteoporosis (BMD < 80 mg/cc) was 29% in non-augmented and 85% in augmented LSF. Seven of 48 patients with non-augmented (15%) and 4 of 33 patients with augmented LSF (12%) had reoperation. In non-augmented LSF, patients with reoperation had significantly lower BMD than patients without reoperation (P = 0.005). The best cut-off to predict reoperation after non-augmented LSF was BMD < 83.7 mg/cc. In the case-control study, patients with reoperation presented numerically lower BMD of 78.8 +/- 33.1 mg/cc than patients without reoperation with BMD of 89.4 +/- 39.7 mg/cc (P = 0.357). Despite much lower BMD surgeries with PMMA-augmentation showed no higher reoperation rate compared to non-augmented surgeries. Patients with reoperation following LSF showed slightly lower BMD compared to matched patients without reoperation, but the difference was not statistically significant. Opportunistic BMD screening can be performed in preoperative CT, thus informing about osteoporotic bone, a potential risk factor of surgery failure., Comment: 16 pages, 2 figures, 4 tables

Published
2019
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42. DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment

Author

Bernhardt, Denise, König, Laila, Grosu, Anca-L., Rieken, Stefan, Krieg, Sandro M., Wick, Wolfgang, Wiestler, Benedikt, Schmidt-Graf, Friederike, Sahm, Felix, Gempt, Jens, Meyer, Bernhard, Krause, Bernd J., Petersen, Cordula, Fietkau, Rainer, Thomas, Michael, Giordano, Frank, Wittig-Sauerwein, Andrea, Debus, Jürgen, Tabatabai, Ghazaleh, Hau, Peter, Steinbach, Joachim, and Combs, Stephanie E.

Published
2022
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43. DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis

Author

Bernhardt, Denise, König, Laila, Grosu, Anca, Wiestler, Benedikt, Rieken, Stefan, Wick, Wolfgang, Gempt, Jens, Krieg, Sandro M., Schmidt-Graf, Friederike, Sahm, Felix, Meyer, Bernhard, Krause, Bernd J., Petersen, Cordula, Fietkau, Rainer, Thomas, Michael, Giordano, Frank, Wittig-Sauerwein, Andrea, Debus, Jürgen, Tabatabai, Ghazaleh, Hau, Peter, Steinbach, Joachim, and Combs, Stephanie E.

Published
2022
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49. A randomized, single ascending dose safety, tolerability and pharmacokinetics study of NicaPlant® in aneurysmal subarachnoid hemorrhage patients undergoing clipping

Author

Kerschbaumer, Johannes, Freyschlag, Christian Franz, Petr, Ondra, Adage, Tiziana, Breitenbach J, Joerg, Wessels, Lars, Wolf, Stefan, Hecht, Nils, Gempt, Jens, Wostrack, Maria, Gmeiner, Matthias, Gollwitzer, Maria, Stefanits, Harald, Bendszus M, Martin, Gruber, Andreas, Meyer, Bernhard, Vajkoczy, Peter, and Thomé, Claudius

Published
2023
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