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228 results on '"Mewes, H. W."'

1. Life with 6000 Genes

Author

Goffeau, A., Barrell, B. G., Bussey, H., Davis, R. W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J. D., Jacq, C., Johnston, M., Louis, E. J., Mewes, H. W., Murakami, Y., Philippsen, P., Tettelin, H., and Oliver, S. G.

Published
1996

9. CYGD: the Comprehensive Yeast Genome Database

Author

Güldener, U., Münsterkötter, M., Kastenmüller, G., Strack, N., van Helden, J., Lemer, C., Richelles, J., Wodak, S. J., García-Martínez, J., Pérez-Ortín, J. E., Michael, H., Kaps, A., Talla, E., Dujon, B., André, B., Souciet, J. L., De Montigny, J., Bon, E., Gaillardin, C., and Mewes, H. W.

Published
2005

12. The Helmholtz Network for Bioinformatics: an integrative web portal for bioinformatics resources

Author

Crass, T., Antes, I., Basekow, R., Bork, P., Buning, C., Christensen, M., Clauen, H., Ebeling, C., Ernst, P., Gailus-Durner, V., Glatting, K.-H., Gohla, R., Göling, F., Grote, K., Heidtke, K., Herrmann, A., OʼKeeffe, S., Kielich, O., Kolibal, S., Korbel, J. O., Lengauer, T., Liebich, I., van der Linden, M., Luz, H., Meissner, K., von Mering, C., Mevissen, H.-T., Mewes, H.-W., Michael, H., Mokrejs, M., Müller, T., Pospisil, H., Rarey, M., Reich, J. G., Schneider, R., Schomburg, D., Schulze-Kremer, S., Schwarzer, K., Sommer, I., Springstubbe, S., Suhai, S., Thoppae, G., Vingron, M., Warfsmann, J., Werner, T., Wetzler, D., Wingender, E., and Zimmer, R.

Published
2004

18. Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana

Author

Bevan, M., Bancroft, I., Bent, E., Love, K., Goodman, H., Dean, C., Bergkamp, R., Dirkse, W., Van Staveren, M., Stiekema, W., Drost, L., Ridley, P., Hudson, S.-A., Patel, K., Murphy, G., Piffanelli, P., Wedler, H., Wedler, E., Wambutt, R., Weitzenegger, T., Pohl, T. M., Terryn, N., Gielen, J., Villarroel, R., De Clerck, R., Van Montagu, M., Lecharny, A., Auborg, S., Gy, I., Kreis, M., Lao, N., Kavanagh, T., Hempel, S., Kotter, P., Entian, K.-D., Rieger, M., Schaeffer, M., Funk, B., Mueller-Auer, S., Silvey, M., James, R., Montfort, A., Pons, A., Puigdomenech, P., Douka, A., Voukelatou, E., Millioni, D., Hatzopoulos, P., Piravandi, E., Obermaier, B., Hilbert, H., Dusterhoft, A., Moores, T., Jones, J. D. G., Eneva, T., Palme, K., Benes, V., Rechman, S., Ansorge, W., Cooke, R., Berger, C., Delseny, M., Voet, M., Volckaert, G., Mewes, H.-W., Klosterman, S., Schueller, C., and Chalwatzis, N.

Published
1998

21. Overview of the yeast genome

Author

Mewes, H. W., Albermann, K., Bähr, M., Frishman, D., Gleissner, A., Hani, J., Heumann, K., Kleine, K., Maierl, A., Oliver, S. G., Pfeiffer, F., and Zollner, A.

Published
1997
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23. The Yeast Genome Directory

Author

Goffeau, A., Aert, R., Agostini-Carbone, M. L., Ahmed, A., Aigle, M., Alberghina, L., Albermann, K., Albers, M., Aldea, M., Alexandraki, D., Aljinovic, G., Allen, E., Alt-Mörbe, J., André, B., Andrews, S., Ansorge, W., Antoine, G., Anwar, R., Aparicio, A., Araujo, R., Arino, J., Arnold, F., Arroyo, J., Aviles, E., Backes, U., Baclet, M. C., Badcock, K., Bahr, A., Baladron, V., Ballesta, J. P. G., Bankier, A. T., Banrevi, A., Bargues, M., Baron, L., Barreiros, T., Barrell, B. G., Barthe, C., Barton, A. B., Baur, A., Bécam, A.-M., Becker, A., Becker, I., Beinhauer, J., Benes, V., Benit, P., Berben, G., Bergantino, E., Bergez, P., Berno, A., Bertani, I., Biteau, N., Bjourson, A. J., Blöcker, H., Blugeon, C., Bohn, C., Boles, E., Bolle, P. A., Bolotin-Fukuhara, M., Bordonné, R., Boskovic, J., Bossier, P., Botstein, D., Bou, G., Bowman, S., Boyer, J., Brandt, P., Brandt, T., Brendel, M., Brennan, T., Brinkman, R., Brown, A., Brown, A. J. P., Brown, D., Brückner, M., Bruschi, C. V., Buhler, J. M., Buitrago, M. J., Bussereau, F., Bussey, H., Camasses, A., Carcano, C., Carignani, G., Carpenter, J., Casamayor, A., Casas, C., Castagnoli, L., Cederberg, H., Cerdan, E., Chalwatzis, N., Chanet, R., Chen, E., Chéret, G., Cherry, J. M., Chillingworth, T., Christiansen, C., Chuat, J.-C., Chung, E., Churcher, C., Churcher, C. M., Clark, M. W., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Colleaux, L., Connor, R., Contreras, R., Cooper, J., Copsey, T., Coster, F., Coster, R., Couch, J., Crouzet, M., Cziepluch, C., Daignan-Fornier, B., Dal Paro, F., Dang, D. V., D’Angelo, M., Davies, C. J., Davis, K., Davis, R. W., De Antoni, A., Dear, S., Dedman, K., Defoor, E., De Haan, M., Delaveau, Th., Del Bino, S., Delgado, M., Delius, H., Delneri, D., Del Rey, F., Demolder, J., Démolis, N., Devlin, K., de Wergifosse, P., Dietrich, F. S., Ding, H., Dion, C., Dipaolo, T., Doignon, F., Doira, C., Domdey, H., Dover, J., Du, Z., Dubois, E., Dujon, B., Duncan, M., Durand, P., Düsterhöft, A., Düsterhus, S., Eki, T., El Bakkoury, M., Eide, L. G., Entian, K.-D., Eraso, P., Erdmann, D., Erfle, H., Escribano, V., Esteban, M., Fabiani, L., Fabre, F., Fairhead, C., Fartmann, B., Favello, A., Faye, G., Feldmann, H., Fernandes, L., Feroli, F., Feuermann, M., Fiedler, T., Fiers, W., Fleig, U. N., Flöth, M., Fobo, G. M., Fortin, N., Foury, F., Francingues-Gaillard, M. C., Franco, L., Fraser, A., Friesen, J.D., Fritz, C., Frontali, L., Fukuhara, H., Fulton, L., Fuller, L. J., Gabel, C., Gaillardin, C., Gaillon, L., Galibert, F., Galisson, F., Galland, P., Gamo, F.-J., Gancedo, C., Garcia-Cantalejo, J. M., García-Gonzalez, M. I., Garcia-Ramirez, J. J., García-Saéz, M., Gassenhuber, H., Gatius, M., Gattung, S., Geisel, C., Gent, M. E., Gentles, S., Ghazvini, M., Gigot, D., Gilliquet, V., Glansdorff, N., Gómez-Peris, A., Gonzaléz, A., Goulding, S. E., Granotier, C., Greco, T., Grenson, M., Grisanti, P., Grivell, L. A., Grothues, D., Gueldener, U., Guerreiro, P., Guzman, E., Haasemann, M., Habbig, B., Hagiwara, H., Hall, J., Hallsworth, K., Hamlin, N., Hand, N. J., Hanemann, V., Hani, J., Hankeln, T., Hansen, M., Harris, D., Harris, D. E., Hartzell, G., Hatat, D., Hattenhorst, U., Hawkins, J., Hebling, U., Hegemann, J., Hein, C., Hennemann, A., Hennessy, K., Herbert, C. J., Hernandez, K., Hernando, Y., Herrero, E., Heumann, K., Heuss- Neitzel, D., Hewitt, N., Hiesel, R., Hilbert, H., Hilger, F., Hillier, L., Ho, C., Hoenicka, J., Hofmann, B., Hoheisel, J., Hohmann, S., Hollenberg, C. P., Holmstrøm, K., Horaitis, O., Horsnell, T. S., Huang, M.-E., Hughes, B., Hunicke-Smith, S., Hunt, S., Hunt, S. E., Huse, K., Hyman, R. W., Iborra, F., Indge, K. J., Iraqui Houssaini, I., Isono, K., Jacq, C., Jacquet, M., Jacquier, A., Jagels, K., Jäger, W., James, C. M., Jauniaux, J. C., Jia, Y., Jier, M., Jimenez, A., Johnson, D., Johnston, L., Johnston, M., Jones, M., Jonniaux, J.-L., Kaback, D. B., Kallesøe, T., Kalman, S., Kalogeropoulos, A., Karpfinger-Hartl, L., Kashkari, D., Katsoulou, C., Kayser, A., Kelly, A., Keng, T., Keuchel, H., Kiesau, P., Kirchrath, L., Kirsten, J., Kleine, K., Kleinhans, U., Klima, R., Komp, C., Kordes, E., Korol, S., Kötter, P., Krämer, C., Kramer, B., Kreisl, P., Kucaba, T., Kuester, H., Kurdi, O., Laamanen, P., Lafuente, M. J., Landt, O., Lanfranchi, G., Langston, Y., Lashkari, D., Latreille, P., Lauquin, G., Le, T., Legrain, P., Legros, Y., Lepingle, A., Lesveque, H., Leuther, H., Lew, H., Lewis, C., Li, Z. Y., Liebl, S., Lin, A., Lin, D., Logghe, M., Lohan, A. J. E., Louis, E. J., Lucchini, G., Lutzenkirchen, K., Lyck, R., Lye, G., Maarse, A. C., Maat, M. J., Macri, C., Madania, A., Maftahi, M., Maia e Silva, A., Maillier, E., Mallet, L., Mannhaupt, G., Manus, V., Marathe, R., Marck, C., Marconi, A., Mardis, E., Martegani, E., Martin, R., Mathieu, A., Maurer, C. T. C., Mazón, M. J., Mazzoni, C., McConnell, D., McDonald, S., McKee, R. A., McReynolds, A. D. K., Melchioretto, P., Menezes, S., Messenguy, F., Mewes, H. W., Michaux, G., Miller, N., Minenkova, O., Miosga, T., Mirtipati, S., Möller-Rieker, S., Möstl, D., Molemans, F., Monnet, A., Monnier, A-L., Montague, M. A., Moro, M., Mosedale, D., Möstl, D., Moule, S., Mouser, L., Murakami, Y., Müller-Auer, S., Mulligan, J., Murphy, L., Muzi Falconi, M., Naitou, M., Nakahara, K., Namath, A., Nasr, F., Navas, L., Nawrocki, A., Nelson, J., Nentwich, U., Netter, P., Neu, R., Newlon, C. S., Nhan, M., Nicaud, J.-M., Niedenthal, R. K., Nombela, C., Noone, D., Norgren, R., Nußbaumer, B., Obermaier, B., Odell, C., Öfner, P., Oh, C., Oliver, K., Oliver, S. G., Ouellette, B. F., Ozawa, M., Paces, V., Pallier, C., Pandolfo, D., Panzeri, L., Paoluzi, S., Parle-Mcdermott, A. G., Pascolo, S., Patricio, N., Pauley, A., Paulin, L., Pearson, B. M., Pearson, D., Peluso, D., Perea, J., Pérez-Alonso, M., Pérez-Ortin, J. E., Perrin, A., Petel, F. X., Pettersson, B., Pfeiffer, F., Philippsen, P., Piérard, A., Piravandi, E., Planta, R. J., Plevani, P., Poch, O., Poetsch, B., Pohl, F. M., Pohl, T. M., Pöhlmann, R., Poirey, R., Portetelle, D., Portillo, F., Potier, S., Proft, M., Prydz, H., Pujol, A., Purnelle, B., Puzos, V., Rajandream, M. A., Ramezani Rad, M., Rasmussen, S. W., Raynal, A., Rechmann, S., Remacha, M., Revuelta, J. L., Rice, P., Richard, G-F., Richterich, P., Rieger, M., Rifken, L., Riles, L., Rinaldi, T., Rinke, M., Roberts, A. B., Roberts, D., Rodriguez, F., Rodriguez-Belmonte, E., Rodriguez-Pousada, C., Rodriguez-Torres, A. M., Rose, M., Rossau, R., Rowley, N., Rupp, T., Ruzzi, M., Saeger, W., Saiz, J. E., Saliola, M., Salom, D., Saluz, H. P., Sánchez-Perez, M., Santos, M. A., Sanz, E., Sanz, J. E., Saren, A.-M., Sartorello, F., Sasanuma, M., Sasanuma, S-I., Scarcez, T., Schaaf-Gerstenschläger, I., Schäfer, B., Schäfer, M., Scharfe, M., Scherens, B., Schroff, N., Sen-Gupta, M., Shibata, T., Schmidheini, T., Schmidt, E. R., Schneider, C., Scholler, P., Schramm, S., Schreer, A., Schröder, M., Schwager, C., Schwarz, S., Schwarzlose, C., Schweitzer, B., Schweizer, M., Sdicu, A-M., Sehl, P., Sensen, C., Sgouros, J. G., Shogren, T., Shore, L., Shu, Y., Skala, J., Skelton, J., Slonimski, P. P., Smit, P. H. M., Smith, V., Soares, H., Soeda, E., Soler-Mira, A., Sor, F., Soriano, N., Souciet, J. L., Soustelle, C., Spiegelberg, R., Stateva, L. I., Steensma, H. Y., Stegemann, J., Steiner, S., Stellyes, L., Sterky, F., Storms, R. K., St. Peter, H., Stucka, R., Taich, A., Talla, E., Tarassov, I., Tashiro, H., Taylor, P., Teodoru, C., Tettelin, H., Thierry, A., Thireos, G., Tobiasch, E., Tovan, D., Trevaskis, E., Tsuchiya, Y., Tzermia, M., Uhlen, M., Underwood, A., Unseld, M., Urbanus, J. H. M., Urrestarazu, A., Ushinsky, S., Valens, M., Valle, G., Van Broekhoven, A., Vandenbol, M., Van Der Aart, Q. J. M., Van Der Linden, C. G., Van Dyck, L., Vanoni, M., Van Vliet-Reedijk, J. C., Vassarotti, A., Vaudin, M., Vaughan, K., Verhasselt, P., Vetter, I., Vierendeels, F., Vignati, D., Vilela, C., Vissers, S., Vleck, C., Vo, D. T., Vo, D. H., Voet, M., Volckaert, G., Von Wettstein, D., Voss, H., Vreken, P., Wagner, G., Walsh, S. V., Wambutt, R., Wang, H., Wang, Y., Warmington, J. R., Waterston, R., Watson, M. D., Weber, N., Wedler, E., Wedler, H., Wei, Y., Whitehead, S., Wicksteed, B. L., Wiemann, S., Wilcox, L., Wilson, C., Wilson, R., Winant, A., Winnett, E., Winsor, B., Wipfli, P., Wölfl, S., Wohldman, P., Wolf, K., Wolfe, K. H., Wright, L. F., Wurst, H., Xu, G., Yamasaki, M., Yelton, M. A., Yokohama, K., Yoshikawa, A., Yuping, S., Zaccaria, P., Zagulski, M., Zimmermann, F. K., Zimmermann, J., Zimmermann, M., Zhong, W-W., Zollner, A., and Zumstein, E.

Published
1997
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24. The PIR-International Protein Sequence Database

Author

Barker, W C, Garavelli, J S, McGarvey, P B, Marzec, C R, Orcutt, B C, Srinivasarao, G Y, Yeh, L S, Ledley, R S, Mewes, H W, Pfeiffer, F, Tsugita, A, and Wu, C

Subjects
Genome, Sequence Homology, Amino Acid, Databases, Factual, International Cooperation, education, Computational Biology, Information Storage and Retrieval, Proteins, Computer Communication Networks, Genetics, Animals, Humans, Amino Acid Sequence, Research Article
Abstract

The Protein Information Resource (PIR; http://www-nbrf.georgetown. edu/pir/) supports research on molecular evolution, functional genomics, and computational biology by maintaining a comprehensive, non-redundant, well-organized and freely available protein sequence database. Since 1988 the database has been maintained collaboratively by PIR-International, an international association of data collection centers cooperating to develop this resource during a period of explosive growth in new sequence data and new computer technologies. The PIR Protein Sequence Database entries are classified into superfamilies, families and homology domains, for which sequence alignments are available. Full-scale family classification supports comparative genomics research, aids sequence annotation, assists database organization and improves database integrity. The PIR WWW server supports direct on-line sequence similarity searches, information retrieval, and knowledge discovery by providing the Protein Sequence Database and other supplementary databases. Sequence entries are extensively cross-referenced and hypertext-linked to major nucleic acid, literature, genome, structure, sequence alignment and family databases. The weekly release of the Protein Sequence Database can be accessed through the PIR Web site. The quarterly release of the database is freely available from our anonymous FTP server and is also available on CD-ROM with the accompanying ATLAS database search program.

Published
1998
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26. OMICS AND PROGNSTIC MARKERS

Author

Adachi, K., primary, Sasaki, H., additional, Nagahisa, S., additional, Yoshida, K., additional, Hattori, N., additional, Nishiyama, Y., additional, Kawase, T., additional, Hasegawa, M., additional, Abe, M., additional, Hirose, Y., additional, Alentorn, A., additional, Marie, Y., additional, Poggioli, S., additional, Alshehhi, H., additional, Boisselier, B., additional, Carpentier, C., additional, Mokhtari, K., additional, Capelle, L., additional, Figarella-Branger, D., additional, Hoang-Xuan, K., additional, Sanson, M., additional, Delattre, J.-Y., additional, Idbaih, A., additional, Yust-Katz, S., additional, Anderson, M., additional, Olar, A., additional, Eterovic, A., additional, Ezzeddine, N., additional, Chen, K., additional, Zhao, H., additional, Fuller, G., additional, Aldape, K., additional, de Groot, J., additional, Andor, N., additional, Harness, J., additional, Lopez, S. G., additional, Fung, T. L., additional, Mewes, H. W., additional, Petritsch, C., additional, Arivazhagan, A., additional, Somasundaram, K., additional, Thennarasu, K., additional, Pandey, P., additional, Anandh, B., additional, Santosh, V., additional, Chandramouli, B., additional, Hegde, A., additional, Kondaiah, P., additional, Rao, M., additional, Bell, R., additional, Kang, R., additional, Hong, C., additional, Song, J., additional, Costello, J., additional, Nagarajan, R., additional, Zhang, B., additional, Diaz, A., additional, Wang, T., additional, Bie, L., additional, Li, Y., additional, Liu, H., additional, Luyo, W. F. C., additional, Carnero, M. H., additional, Iruegas, M. E. P., additional, Morell, A. R., additional, Figueiras, M. C., additional, Lopez, R. L., additional, Valverde, C. F., additional, Chan, A. K.-Y., additional, Pang, J. C.-S., additional, Chung, N. Y.-F., additional, Li, K. K.-W., additional, Poon, W. S., additional, Chan, D. T.-M., additional, Wang, Y., additional, Ng, H.-a. K., additional, Chaumeil, M., additional, Larson, P., additional, Yoshihara, H., additional, Vigneron, D., additional, Nelson, S., additional, Pieper, R., additional, Phillips, J., additional, Ronen, S., additional, Clark, V., additional, Omay, Z. E., additional, Serin, A., additional, Gunel, J., additional, Omay, B., additional, Grady, C., additional, Youngblood, M., additional, Bilguvar, K., additional, Baehring, J., additional, Piepmeier, J., additional, Gutin, P., additional, Vortmeyer, A., additional, Brennan, C., additional, Pamir, M. N., additional, Kilic, T., additional, Krischek, B., additional, Simon, M., additional, Yasuno, K., additional, Gunel, M., additional, Cohen, A. L., additional, Sato, M., additional, Aldape, K. D., additional, Mason, C., additional, Diefes, K., additional, Heathcock, L., additional, Abegglen, L., additional, Shrieve, D., additional, Couldwell, W., additional, Schiffman, J. D., additional, Colman, H., additional, D'Alessandris, Q. G., additional, Cenci, T., additional, Martini, M., additional, Ricci-Vitiani, L., additional, De Maria, R., additional, Larocca, L. M., additional, Pallini, R., additional, Theeler, B., additional, Lang, F., additional, Rao, G., additional, Gilbert, M., additional, Sulman, E., additional, Luthra, R., additional, Eterovic, K., additional, Routbort, M., additional, Verhaak, R., additional, Mills, G., additional, Mendelsohn, J., additional, Meric-Bernstam, F., additional, Yung, A., additional, MacArthur, K., additional, Hahn, S., additional, Kao, G., additional, Lustig, R., additional, Alonso-Basanta, M., additional, Chandrasekaran, S., additional, Wileyto, E. P., additional, Reyes, E., additional, Dorsey, J., additional, Fujii, K., additional, Kurozumi, K., additional, Ichikawa, T., additional, Onishi, M., additional, Ishida, J., additional, Shimazu, Y., additional, Kaur, B., additional, Chiocca, E. A., additional, Date, I., additional, Geisenberger, C., additional, Mock, A., additional, Warta, R., additional, Schwager, C., additional, Hartmann, C., additional, von Deimling, A., additional, Abdollahi, A., additional, Herold-Mende, C., additional, Gevaert, O., additional, Achrol, A., additional, Gholamin, S., additional, Mitra, S., additional, Westbroek, E., additional, Loya, J., additional, Mitchell, L., additional, Chang, S., additional, Steinberg, G., additional, Plevritis, S., additional, Cheshier, S., additional, Xu, J., additional, Napel, S., additional, Zaharchuk, G., additional, Harsh, G., additional, Gutman, D., additional, Holder, C., additional, Colen, R., additional, Dunn, W., additional, Jain, R., additional, Cooper, L., additional, Hwang, S., additional, Flanders, A., additional, Brat, D., additional, Hayes, J., additional, Droop, A., additional, Thygesen, H., additional, Boissinot, M., additional, Westhead, D., additional, Short, S., additional, Lawler, S., additional, Bady, P., additional, Kurscheid, S., additional, Delorenzi, M., additional, Hegi, M. E., additional, Crosby, C., additional, Faulkner, C., additional, Smye-Rumsby, T., additional, Kurian, K., additional, Williams, M., additional, Hopkins, K., additional, Palmer, A., additional, Williams, H., additional, Wragg, C., additional, Haynes, H. R., additional, Kurian, K. M., additional, White, P., additional, Oka, T., additional, Jalbert, L., additional, Elkhaled, A., additional, Jensen, R., additional, Salzman, K., additional, Schabel, M., additional, Gillespie, D., additional, Mumert, M., additional, Johnson, B., additional, Mazor, T., additional, Barnes, M., additional, Yamamoto, S., additional, Ueda, H., additional, Tatsuno, K., additional, Aihara, K., additional, Bollen, A., additional, Hirst, M., additional, Marra, M., additional, Mukasa, A., additional, Saito, N., additional, Aburatani, H., additional, Berger, M., additional, Taylor, B., additional, Popov, S., additional, Mackay, A., additional, Ingram, W., additional, Burford, A., additional, Jury, A., additional, Vinci, M., additional, Jones, C., additional, Jones, D. T. W., additional, Hovestadt, V., additional, Picelli, S., additional, Wang, W., additional, Northcott, P. A., additional, Kool, M., additional, Reifenberger, G., additional, Pietsch, T., additional, Sultan, M., additional, Lehrach, H., additional, Yaspo, M.-L., additional, Borkhardt, A., additional, Landgraf, P., additional, Eils, R., additional, Korshunov, A., additional, Zapatka, M., additional, Radlwimmer, B., additional, Pfister, S. M., additional, Lichter, P., additional, Joy, A., additional, Smirnov, I., additional, Reiser, M., additional, Shapiro, W., additional, Kim, S., additional, Feuerstein, B., additional, Jungk, C., additional, Friauf, S., additional, Unterberg, A., additional, Juratli, T. A., additional, McElroy, J., additional, Meng, W., additional, Huebner, A., additional, Geiger, K. D., additional, Krex, D., additional, Schackert, G., additional, Chakravarti, A., additional, Lautenschlaeger, T., additional, Kim, B. Y., additional, Jiang, W., additional, Beiko, J., additional, Prabhu, S., additional, DeMonte, F., additional, Sawaya, R., additional, Cahill, D., additional, McCutcheon, I., additional, Lau, C., additional, Wang, L., additional, Terashima, K., additional, Yamaguchi, S., additional, Burstein, M., additional, Sun, J., additional, Suzuki, T., additional, Nishikawa, R., additional, Nakamura, H., additional, Natsume, A., additional, Terasaka, S., additional, Ng, H.-K., additional, Muzny, D., additional, Gibbs, R., additional, Wheeler, D., additional, Zhang, X.-q., additional, Sun, S., additional, Lam, K.-f., additional, Kiang, K. M. Y., additional, Pu, J. K. S., additional, Ho, A. S. W., additional, Leung, G. K. K., additional, Loebel, F., additional, Curry, W. T., additional, Barker, F. G., additional, Lelic, N., additional, Chi, A. S., additional, Cahill, D. P., additional, Lu, D., additional, Yin, J., additional, Teo, C., additional, McDonald, K., additional, Madhankumar, A., additional, Weston, C., additional, Slagle-Webb, B., additional, Sheehan, J., additional, Patel, A., additional, Glantz, M., additional, Connor, J., additional, Maire, C., additional, Francis, J., additional, Zhang, C.-Z., additional, Jung, J., additional, Manzo, V., additional, Adalsteinsson, V., additional, Homer, H., additional, Blumenstiel, B., additional, Pedamallu, C. S., additional, Nickerson, E., additional, Ligon, A., additional, Love, C., additional, Meyerson, M., additional, Ligon, K., additional, Jalbert, L. E., additional, Nelson, S. J., additional, Bollen, A. W., additional, Smirnov, I. V., additional, Song, J. S., additional, Olshen, A. B., additional, Berger, M. S., additional, Chang, S. M., additional, Taylor, B. S., additional, Costello, J. F., additional, Mehta, S., additional, Armstrong, B., additional, Peng, S., additional, Bapat, A., additional, Berens, M., additional, Melendez, B., additional, Mollejo, M., additional, Mur, P., additional, Hernandez-Iglesias, T., additional, Fiano, C., additional, Ruiz, J., additional, Rey, J. A., additional, Stadler, V., additional, Schulte, A., additional, Lamszus, K., additional, Schichor, C., additional, Westphal, M., additional, Tonn, J.-C., additional, Morozova, O., additional, Katzman, S., additional, Grifford, M., additional, Salama, S., additional, Haussler, D., additional, Olshen, A., additional, Fouse, S., additional, Nakamizo, S., additional, Sasayama, T., additional, Tanaka, H., additional, Tanaka, K., additional, Mizukawa, K., additional, Yoshida, M., additional, Kohmura, E., additional, Northcott, P., additional, Jones, D., additional, Pfister, S., additional, Otani, R., additional, Takayanagi, S., additional, Saito, K., additional, Tanaka, S., additional, Shin, M., additional, Ozawa, T., additional, Riester, M., additional, Cheng, Y.-K., additional, Huse, J., additional, Helmy, K., additional, Charles, N., additional, Squatrito, M., additional, Michor, F., additional, Holland, E., additional, Perrech, M., additional, Dreher, L., additional, Rohn, G., additional, Goldbrunner, R., additional, Timmer, M., additional, Pollo, B., additional, Palumbo, V., additional, Calatozzolo, C., additional, Patane, M., additional, Nunziata, R., additional, Farinotti, M., additional, Silvani, A., additional, Lodrini, S., additional, Finocchiaro, G., additional, Lopez, E., additional, Rioscovian, A., additional, Ruiz, R., additional, Siordia, G., additional, de Leon, A. P., additional, Rostomily, C., additional, Rostomily, R., additional, Silbergeld, D., additional, Kolstoe, D., additional, Chamberlain, M., additional, Silber, J., additional, Roth, P., additional, Keller, A., additional, Hoheisel, J., additional, Codo, P., additional, Bauer, A., additional, Backes, C., additional, Leidinger, P., additional, Meese, E., additional, Thiel, E., additional, Korfel, A., additional, Weller, M., additional, Nagae, G., additional, Nagane, M., additional, Sanborn, J. Z., additional, Mikkelsen, T., additional, Jhanwar, S., additional, Chin, L., additional, Nishihara, M., additional, Schliesser, M., additional, Grimm, C., additional, Weiss, E., additional, Claus, R., additional, Weichenhan, D., additional, Weiler, M., additional, Hielscher, T., additional, Sahm, F., additional, Wiestler, B., additional, Klein, A.-C., additional, Blaes, J., additional, Plass, C., additional, Wick, W., additional, Stragliotto, G., additional, Rahbar, A., additional, Soderberg-Naucler, C., additional, Won, M., additional, Ezhilarasan, R., additional, Sun, P., additional, Blumenthal, D., additional, Vogelbaum, M., additional, Jenkins, R., additional, Jeraj, R., additional, Brown, P., additional, Jaeckle, K., additional, Schiff, D., additional, Dignam, J., additional, Atkins, J., additional, Brachman, D., additional, Werner-Wasik, M., additional, Mehta, M., additional, Shen, J., additional, Luan, J., additional, Yu, A., additional, Matsutani, M., additional, Liang, Y., additional, Man, T.-K., additional, Trister, A., additional, Tokita, M., additional, Mikheeva, S., additional, Mikheev, A., additional, Friend, S., additional, van den Bent, M., additional, Erdem, L., additional, Gorlia, T., additional, Taphoorn, M., additional, Kros, J., additional, Wesseling, P., additional, Dubbink, H., additional, Ibdaih, A., additional, French, P., additional, van Thuijl, H., additional, Heimans, J., additional, Ylstra, B., additional, Reijneveld, J., additional, Prabowo, A., additional, Scheinin, I., additional, van Essen, H., additional, Spliet, W., additional, Ferrier, C., additional, van Rijen, P., additional, Veersema, T., additional, Thom, M., additional, Meeteren, A. S.-v., additional, Aronica, E., additional, Kim, H., additional, Zheng, S., additional, Brat, D. J., additional, Virk, S., additional, Amini, S., additional, Sougnez, C., additional, Barnholtz-Sloan, J., additional, Verhaak, R. G. W., additional, Watts, C., additional, Sottoriva, A., additional, Spiteri, I., additional, Piccirillo, S., additional, Touloumis, A., additional, Collins, P., additional, Marioni, J., additional, Curtis, C., additional, Tavare, S., additional, Tews, B., additional, Yeung, T. P. C., additional, Al-Khazraji, B., additional, Morrison, L., additional, Hoffman, L., additional, Jackson, D., additional, Lee, T.-Y., additional, Yartsev, S., additional, Bauman, G., additional, Fu, J., additional, Vegesna, R., additional, Mao, Y., additional, Heathcock, L. E., additional, Torres-Garcia, W., additional, Wang, S., additional, McKenna, A., additional, Brennan, C. W., additional, Yung, W. K. A., additional, Weinstein, J. N., additional, Sulman, E. P., additional, and Koul, D., additional

Published
2013
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27. Functional Characterization of the Human Peroxins PEX3 and PEX19, Proteins Essential for Early Peroxisomal Membrane Biogenesis

Author

Adamski, J. (Priv.-Doz. Dr.rer.nat. Dr.rer.biol.hum.habil.), Mewes, H.-W. (Univ.-Prof. Dr.rer.nat), Roscher, A. A. (Univ.-Prof. Dr.med.), Mayerhofer, Peter Uli, Adamski, J. (Priv.-Doz. Dr.rer.nat. Dr.rer.biol.hum.habil.), Mewes, H.-W. (Univ.-Prof. Dr.rer.nat), Roscher, A. A. (Univ.-Prof. Dr.med.), and Mayerhofer, Peter Uli

Abstract

Peroxisomes are single-membrane-bound organelles present in virtually all eukaryotic cells. Their significance in human metabolism is illustrated by the existence of severe inherited diseases caused by the failure of peroxisomal biogenesis (peroxisomal biogenesis disorders; PBDs). Proteins required for peroxisomal assembly are termed “peroxins” and are encoded by at least 23 PEX-genes. In most cases, defects in PEX genes lead to a disruption of peroxisomal matrix protein import, whereas various peroxisomal membrane components are synthesized and accumulate in peroxisomal membrane remnants (“peroxisomal ghosts”). Since yeast mutants in PEX3 and PEX19 have been shown to lack peroxisomal ghosts, these peroxins were expected to be involved in the early stages of peroxisomal membrane synthesis. This work focused on the functional characterization of human PEX3 and PEX19 to gain insights into their role in human biology and disease. PEX19 was shown to interact with three peroxisomal ABC half-transporters (Adrenoleukodystrophy protein ALDP, Adrenoleukodystrophy-related protein ALDRP, and the 70 kDa peroxisomal membrane protein PMP70), confirming its role as a broad specific peroxisomal membrane-protein binding-protein. As a prerequisite for these protein-protein interaction assays, the human ALDR gene was characterized. Proteins encoded by two PEX19 splice variants showed a considerable functional diversity as to peroxisomal membrane protein binding and with respect to induction of peroxisomal formation in PEX19-deficient human fibroblasts. Farnesylation of PEX19 was shown not to be essential for these functions. These data provide the first experimental evidence for specific biological functions of the different predicted domains of the PEX19 protein. In order to investigate the molecular details of peroxisomal assembly and to evaluate experimental treatment strategies for the peroxisomal biogenesis disorders, data useful for the future generation of a mouse model with ta, Peroxisomen sind von einer einschichtigen Membran umgebene Zellorganellen, die nahezu in allen eukaryontischen Zellen vorkommen. Ihre Bedeutung im menschlichen Stoffwechsel wird durch eine Reihe schwerer genetischer Erkrankungen belegt, die durch Defekte der peroxisomalen Biogenese ausgelöst werden (Peroxisomale Biogenesedefekte, PBD). An der peroxisomalen Biogenese sind mindestens 23 Proteine (Peroxine) beteiligt, die durch PEX-Gene kodiert werden. Meistens wirkt sich der Defekt eines PEX-Gens in einem gestörten peroxisomalen Matrixprotein-Import aus, während peroxisomale Membrankomponenten normal synthetisiert werden und sich in leeren, residualen peroxisomalen Membranstrukturen („peroxisomal ghosts“) ansammeln. Für PEX3-und PEX19-Hefemutanten konnte das Fehlen dieser „peroxisomal ghosts“ gezeigt werden. Diese Beobachtung führten zu der Hypothese, dass beide Peroxine an der frühen peroxisomalen Membransynthese beteiligt sind. Das Ziel dieser Arbeit lag in der funktionellen Charakterisierung der humanen Peroxine PEX3 und PEX19, um neue Erkenntnisse über deren Bedeutung in der Humanbiologie und deren Beteiligung an genetischen Erkrankungen zu erlangen. Es konnte gezeigt werden, dass PEX19 mit drei peroxisomalen ABC-Halb-Transportern (Adrenoleukodystrophieprotein, ALDP; Adrenoleukodystrophie-related Protein, ALDRP; 70 kDa peroxisomalen Membranprotein, PMP70) interagiert. Somit wurde die Rolle von PEX19 als allgemeinspezifisches peroxisomales Membranprotein-Bindeprotein bestätigt. Als Vorarbeit für diese Protein-Protein Interaktionsversuche wurde das humane ALDR-Gen näher charakterisiert. Für Proteine, die von zwei PEX19-Splicevarianten kodiert werden, konnte ein funktioneller Unterschied hinsichtlich peroxisomaler Membranprotein-Interaktion und Einleitung der peroxisomalen Biogenese in PEX19-defizienten humanen Fibroblasten gezeigt werden. Es wurde widerlegt, dass die Farnesylierung von PEX19 essentiell für diese Funktionen ist. Dadurch ergibt sich der erste experime

Published
2007

28. The nucleotide sequence of Saccharomyces cerevisiae chromosome XII

Author

Mark Johnston, Hillier, L., Riles, L., Albermann, K., André, B., Ansorge, W., Benes, V., Brückner, M., Delius, H., Dubois, E., Düsterhöft, A., Entian, K. -D, Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kötter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Miosga, T., Möstl, D., Müller-Auer, S., Nentwich, U., Obermaier, B., Piravandi, E., Pohl, T. M., Portetelle, D., Purnelle, B., Rechmann, S., Rieger, M., Rinke, M., Rose, M., Scharfe, M., Scherens, B., Scholler, P., Schwager, C., Schwarz, S., Underwood, A. P., Urrestarazu, L. A., Vandenbol, M., Verhasselt, P., Vierendeels, F., Voet, M., Volckaert, G., Voss, H., Wambutt, R., Wedler, E., Wedler, H., Zimmermann, F. K., Zollner, A., Hani, J., and Hoheisel, J. D.

Subjects
Base Sequence, Molecular Sequence Data, Saccharomyces cerevisiae, Chromosomes, Fungal, DNA, Fungal, Article
Abstract

The yeast Saccharomyces cerevisiae is the pre-eminent organism for the study of basic functions of eukaryotic cells(1). All of the genes of this simple eukaryotic cell have recently been revealed by an international collaborative effort to determine the complete DNA sequence of its nuclear genome. Here we describe some of the features of chromosome XII.

Published
1997

29. New Approaches in Context-based Protein Function Prediction

Author

Langosch, D. (Univ.-Prof. Dr.rer.nat.habil.), Mewes, H.-W. (Univ.-Prof. Dr.rer.nat.), Dandekar, T. (Univ.-Prof. Dr.med.), Kolesov, Grigory, Langosch, D. (Univ.-Prof. Dr.rer.nat.habil.), Mewes, H.-W. (Univ.-Prof. Dr.rer.nat.), Dandekar, T. (Univ.-Prof. Dr.med.), and Kolesov, Grigory

Abstract

In this work we analyze genomic neighborhood of a gene as a source of functional information. Using concept of Similarity-Neighborhood graph we show presence of non-trivial relations between genomic neighbors in the context of several genomes. We also show that while for prokaryotes the existence of such relations can be deduced from the operonic organization of prokaryotic genomes, these relations can also be detected in the eukaryotic genomes where such organization is not common (with notable exception of Caenorhabditis elegans and possibly othermembers of Nematodae). We demonstrate applicability of the our method for uncovering gene's function and studying properties of genomes. We also demonstrate the techniques and tools developed for the analysis of genomic data. PEDANT genome system has been developed by our group and served as a main foundation for development of Similarity-Neighborhood approach, with the latter coming into life as a separate gene-function prediction tool - SNAPper web server. We discuss the techniques hiding behind our all-against-all protein alignment database, which has been developed as part of PEDANT genome analysis system. Such database is the requirement for nearly any cross-genome comparison approach, as it provides the basis for delineating of orthologous and paralogous groups of genes. One of such approaches - phylogenetic profiling, has been implemented by us in collaboration with Philip Wong and Walid Houry of University of Toronto, as highly flexible Web-based tool called PWP. The Jaba visualisation tool which we developed for manual analysis of the genomes and multiple gene predictions and which has been extensively used in several genome projects, including large eukaryotic genome projects such as Arabidopsis thaliana and Neurospora crassa is also presented., Wir untersuchen genomische Nachbarschaft as eine Quelle funktioneller Informationen über Gene. Basierend auf dem Konzept von Simlarity-Neighborhood Graphen wird gezeigt, wie nicht-triviale Verhältnisse zwischen benachbarten Genen aufgedeckt werden können. Während in Prokaryoten das Vorhandensein solcher Korrelationen auf die Operonstrukturen zurückverfolgt werden kann, wurde dieses Phänomen auch in einigen eukaryontischen Genomen entdeckt, wo Operone in der Regel nicht vorkommen. Wir demonstrieren die Anwendbarkeit dieser Methode zur Genfunktionsvorhersage und Untersuchung von Genomeigenschaften. Darüber hinaus werden folgende Techniken zur Genomanalyse vorgestellt: a) Eine Web-Ressource zur Untersuchung von Similarity-Neighborhood Graphen, b) Die Datenbank von Alignments zur Berechnung von paralogen und orthologen Gengruppen, c) Ein phylogenetic profiling Werkzeug, d) Ein Programm zur Visualisierung genomischer Informationen und multiplen Genvorhersagen.

Published
2006

30. CYGD: the Comprehensive Yeast Genome Database.

Author

Güldener, U, Münsterkötter, M, Kastenmüller, G, Strack, N, van Helden, Jacques, Lemer, C, Richelles, J, Wodak, Shoshana, García-Martínez, J, Pérez-Ortín, J E, Michael, H, Kaps, A, Talla, E., Dujon, B, André, Bruno, Souciet, J L, De Montigny, J, Bon, E, Gaillardin, C, Mewes, H W, Güldener, U, Münsterkötter, M, Kastenmüller, G, Strack, N, van Helden, Jacques, Lemer, C, Richelles, J, Wodak, Shoshana, García-Martínez, J, Pérez-Ortín, J E, Michael, H, Kaps, A, Talla, E., Dujon, B, André, Bruno, Souciet, J L, De Montigny, J, Bon, E, Gaillardin, C, and Mewes, H W

Abstract

The Comprehensive Yeast Genome Database (CYGD) compiles a comprehensive data resource for information on the cellular functions of the yeast Saccharomyces cerevisiae and related species, chosen as the best understood model organism for eukaryotes. The database serves as a common resource generated by a European consortium, going beyond the provision of sequence information and functional annotations on individual genes and proteins. In addition, it provides information on the physical and functional interactions among proteins as well as other genetic elements. These cellular networks include metabolic and regulatory pathways, signal transduction and transport processes as well as co-regulated gene clusters. As more yeast genomes are published, their annotation becomes greatly facilitated using S.cerevisiae as a reference. CYGD provides a way of exploring related genomes with the aid of the S.cerevisiae genome as a backbone and SIMAP, the Similarity Matrix of Proteins. The comprehensive resource is available under http://mips.gsf.de/genre/proj/yeast/., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Published
2005

31. Integrative annotation of 21,037 human genes validated by full-length cDNA clones

Author

Imanishi, T., Itoh, T., Suzuki, Y., O'Donovan, C., Fukuchi, S., Koyanagi, K. O., Barrero, R. A., Tamura, T., Yamaguchi-Kabata, Y., Tanino, M., Yura, K., Miyazaki, S., Ikeo, K., Homma, K., Kasprzyk, A., Nishikawa, T., Hirakawa, M., Thierry-Mieg, J., Thierry-Mieg, D., Ashurst, J., Jia, L., Nakao, M., Thomas, M. A., Mulder, N., Karavidopoulou, Y., Jin, L., Kim, S., Yasuda, T., Lenhard, B., Eveno, E., Yamasaki, C., Takeda, J. -I, Gough, C., Hilton, P., Fujii, Y., Sakai, H., Tanaka, S., Amid, C., Bellgard, M., de Fatima Bonaldo, M., Bono, H., Bromberg, S. K., Brookes, A. J., Bruford, E., Carninci, P., Chelala, C., Couillault, C., de Souza, S. J., Debily, M. -A, Devignes, M. -D, Dubchak, I., Endo, T., Estreicher, A., Eyras, E., Fukami-Kobayashi, K., Gopinath, G. R., Graudens, E., Hahn, Y., Han, M., Han, Z. -G, Hanada, K., Hanaoka, H., Harada, E., Hashimoto, K., Hinz, U., Hirai, M., Hishiki, T., Hopkinson, I., Imbeaud, S., Inoko, H., Kanapin, A., Kaneko, Y., Kasukawa, T., Kelso, J., Kersey, P., Kikuno, R., Kimura, K., Korn, B., Kuryshev, V., Makalowska, I., Makino, T., Mano, S., Mariage-Samson, R., Mashima, J., Matsuda, H., Mewes, H. -W, Minoshima, S., Nagai, K., Nagasaki, H., Nagata, N., Nigam, R., Ogasawara, O., Ohara, O., Ohtsubo, M., Okada, N., Okido, T., Oota, S., Ota, M., Ota, T., Otsuki, T., Piatier-Tonneau, D., Poustka, A., Ren, S. -X, Saitou, N., Sakai, K., Sakamoto, S., Sakate, R., Schupp, I., Servant, F., Sherry, S., Shiba, R., Shimizu, N., Shimoyama, M., Simpson, A. J., Soares, B., Steward, C., Suwa, M., Suzuki, M., Takahashi, A., Tamiya, G., Tanaka, H., Taylor, T., Terwilliger, J. D., Unneberg, Per, Veeramachaneni, V., Watanabe, S., Wilming, L., Yasuda, N., Hyang-Yoo, S., Stodolsky, M., Makalowski, W., Go, M., Nakai, K., Takagi, T., Kanehisa, M., Sakaki, Y., Quackenbush, J., Okazaki, Y., Hayashizaki, Y., Hide, W., Chakraborty, R., Nishikawa, K., Sugawara, H., Tateno, Y., Chen, Z., Oishi, M., Tonellato, P., Apweiler, R., Okubo, K., Wagner, L., Wiemann, S., Strausberg, R. L., Isogai, T., Auffray, C., Nomura, N., Gojobori, T., Sugano, S., Imanishi, T., Itoh, T., Suzuki, Y., O'Donovan, C., Fukuchi, S., Koyanagi, K. O., Barrero, R. A., Tamura, T., Yamaguchi-Kabata, Y., Tanino, M., Yura, K., Miyazaki, S., Ikeo, K., Homma, K., Kasprzyk, A., Nishikawa, T., Hirakawa, M., Thierry-Mieg, J., Thierry-Mieg, D., Ashurst, J., Jia, L., Nakao, M., Thomas, M. A., Mulder, N., Karavidopoulou, Y., Jin, L., Kim, S., Yasuda, T., Lenhard, B., Eveno, E., Yamasaki, C., Takeda, J. -I, Gough, C., Hilton, P., Fujii, Y., Sakai, H., Tanaka, S., Amid, C., Bellgard, M., de Fatima Bonaldo, M., Bono, H., Bromberg, S. K., Brookes, A. J., Bruford, E., Carninci, P., Chelala, C., Couillault, C., de Souza, S. J., Debily, M. -A, Devignes, M. -D, Dubchak, I., Endo, T., Estreicher, A., Eyras, E., Fukami-Kobayashi, K., Gopinath, G. R., Graudens, E., Hahn, Y., Han, M., Han, Z. -G, Hanada, K., Hanaoka, H., Harada, E., Hashimoto, K., Hinz, U., Hirai, M., Hishiki, T., Hopkinson, I., Imbeaud, S., Inoko, H., Kanapin, A., Kaneko, Y., Kasukawa, T., Kelso, J., Kersey, P., Kikuno, R., Kimura, K., Korn, B., Kuryshev, V., Makalowska, I., Makino, T., Mano, S., Mariage-Samson, R., Mashima, J., Matsuda, H., Mewes, H. -W, Minoshima, S., Nagai, K., Nagasaki, H., Nagata, N., Nigam, R., Ogasawara, O., Ohara, O., Ohtsubo, M., Okada, N., Okido, T., Oota, S., Ota, M., Ota, T., Otsuki, T., Piatier-Tonneau, D., Poustka, A., Ren, S. -X, Saitou, N., Sakai, K., Sakamoto, S., Sakate, R., Schupp, I., Servant, F., Sherry, S., Shiba, R., Shimizu, N., Shimoyama, M., Simpson, A. J., Soares, B., Steward, C., Suwa, M., Suzuki, M., Takahashi, A., Tamiya, G., Tanaka, H., Taylor, T., Terwilliger, J. D., Unneberg, Per, Veeramachaneni, V., Watanabe, S., Wilming, L., Yasuda, N., Hyang-Yoo, S., Stodolsky, M., Makalowski, W., Go, M., Nakai, K., Takagi, T., Kanehisa, M., Sakaki, Y., Quackenbush, J., Okazaki, Y., Hayashizaki, Y., Hide, W., Chakraborty, R., Nishikawa, K., Sugawara, H., Tateno, Y., Chen, Z., Oishi, M., Tonellato, P., Apweiler, R., Okubo, K., Wagner, L., Wiemann, S., Strausberg, R. L., Isogai, T., Auffray, C., Nomura, N., Gojobori, T., and Sugano, S.

Abstract

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for non-protein-coding RNA genes. In addition, QC 20141211

Published
2004
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32. Editorial

Author

Tretter, F., primary, Rujescu, D., additional, Turck, C. W., additional, and Mewes, H. W., additional

Published
2011
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34. Molecular evolution of eukaryotic genomes: hemiascomycetous yeast spliceosomal introns.

Author

Bon, Elisabeth, Casaregola, Serge, Blandin, Gaëlle, Llorente, Bertrand, Neuvéglise, Cécile, Munsterkotter, Martin, Güldener, Ulrich, Mewes, H W, van Helden, Jacques, Dujon, Bernard, Gaillardin, Claude, Bon, Elisabeth, Casaregola, Serge, Blandin, Gaëlle, Llorente, Bertrand, Neuvéglise, Cécile, Munsterkotter, Martin, Güldener, Ulrich, Mewes, H W, van Helden, Jacques, Dujon, Bernard, and Gaillardin, Claude

Abstract

As part of the exploratory sequencing program Génolevures, visual scrutinisation and bioinformatic tools were used to detect spliceosomal introns in seven hemiascomycetous yeast species. A total of 153 putative novel introns were identified. Introns are rare in yeast nuclear genes (<5% have an intron), mainly located at the 5' end of ORFs, and not highly conserved in sequence. They all share a clear non-random vocabulary: conserved splice sites and conserved nucleotide contexts around splice sites. Homologues of metazoan snRNAs and putative homologues of SR splicing factors were identified, confirming that the spliceosomal machinery is highly conserved in eukaryotes. Several introns' features were tested as possible markers for phylogenetic analysis. We found that intron sizes vary widely within each genome, and according to the phylogenetic position of the yeast species. The evolutionary origin of spliceosomal introns was examined by analysing the degree of conservation of intron positions in homologous yeast genes. Most introns appeared to exist in the last common ancestor of present day yeast species, and then to have been differentially lost during speciation. However, in some cases, it is difficult to exclude a possible sliding event affecting a pre-existing intron or a gain of a novel intron. Taken together, our results indicate that the origin of spliceosomal introns is complex within a given genome, and that present day introns may have resulted from a dynamic flux between intron conservation, intron loss and intron gain during the evolution of hemiascomycetous yeasts., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: re.j, info:eu-repo/semantics/published

Published
2003

38. PEDANT covers all complete RefSeq genomes

Author

Walter, M. C., primary, Rattei, T., additional, Arnold, R., additional, Guldener, U., additional, Munsterkotter, M., additional, Nenova, K., additional, Kastenmuller, G., additional, Tischler, P., additional, Wolling, A., additional, Volz, A., additional, Pongratz, N., additional, Jost, R., additional, Mewes, H.-W., additional, and Frishman, D., additional

Published
2009
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39. Informatics and Medicine

Author

Knoll, A., primary, Mewes, H.-W., primary, Schwaiger, M., primary, Bode, A., primary, Broy, M., primary, Daniel, H., primary, Feussner, H., primary, Gradinger, R., primary, Hauner, H., primary, Höfler, H., primary, Holzmann, B., primary, Horsch, A., primary, Kemper, A., primary, Krcmar, H., primary, Kochs, E. F., primary, Lange, R., primary, Leidl, R., primary, Mansmann, U., primary, Mayr, E. W., primary, Meitinger, T., primary, Molls, M., primary, Navab, N., primary, Nüsslin, F., primary, Peschel, C., primary, Reiser, M., primary, Ring, J., primary, Rummeny, E. J., primary, Schlichter, J., primary, Schmid, R., primary, Wichmann, H. E., primary, Ziegler, S., primary, and Kuhn, K. A., additional

Published
2008
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40. The complete sequence of the yeast chromosome III

Author

Oliver, S. G., van der Aart, Q. J. M., Agostoni Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P. G., Benit, P., Berben, G., Bergantino, Elisabetta, Biteau, N., Bolle, P. A., Bolotin Fukuhara, M., Brown, A., Brown, A. J. P., Buhler, J. M., Carcano, C., Carignani, G., Cederberg, H., Chanet, R., Contreras, R., Crouzet, M., Daignan Fornier, B., Defoor, E., Delgado, M., Demolder, J., Doira, C., Dubois, E., Dujon, B., Dusterhoft, A., Erdmann, D., Esteban, M., Fabre, F., Fairhead, C., Faye, G., Feldmann, H., Fiers, W., Francingues Gaillard, M. C., Franco, L., Frontali, L., Fukuhara, H., Fuller, L. J., Galland, P., Gent, M. E., Gigot, D., Gilliquet, V., Glansdorff, N., Goffeau, A., Grenson, M., Grisanti, P., Grivell, L. A., de Haan, M., Haasemann, M., Hatat, D., Hoenicka, J., Hegemann, J., Herbert, C. J., Hilger, F., Hohmann, S., Hollenberg, C. P., Huse, K., Iborra, F., Indje, K. J., Isono, K., Jacq, C., Jacquet, M., James, C. M., Jauniaux, J. C., Jia, Y., Jimenez, A., Kelly, A., Kleinhans, U., Kreisl, P., Lanfranchi, Gerolamo, Lewis, C, Vanderlinden, C. G., Lucchini, G., Lutzenkirchen, K, Maat, M. J., Mallet, L., Mannhaupet, G., Martegani, E., Mathieu, A., Maurer, C. T. C., Mcconnell, D., Mckee, R. A., Messenguy, F., Mewes, H. W., Molemans, F., Montague, M. A., Muzi Falconi, M., Navas, L., Newlon, C. S., Noone, D., Pallier, C., Panzeri, L., Pearson, B. M., Perea, J., Philippsen, P., Pierard, A., Planta, R. J., Plevani, P., Poetsch, B., Pohl, F., Purnelle, B., Ramezani Rad, M., Rasmussen, S. W., Raynal, A., Remacha, M., Richterich, P., Roberts, A. B., Rodriguez, F., Sanz, E., Schaaff Gerstenschlager, I., Scherens, B., Schweitzer, B., Shu, Y., Skala, J., Slonimski, P. P., Sor, F., Soustelle, C., Spiegelberg, R., Stateva, L. I., Steensma, S., Steiner, H. Y., Thierry, A., Thireos, G., Tzermia, M., Urrestarazu, L. A., Valle, Giorgio, Vetter, I., van Vliet Reedijk, J. C., Voet, M., Volckaert, G., Vreken, P., Wang, H., Warmington, J. R., von Wettstein, D., Wicksteed, B. L., Wilson, C., Wurst, H., Xu, G., Yoshikawa, A., Zimmermann, F. K., and Sgouros, J. G.

Published
1992

41. Quality control in databanks for molecular biology

Author

Abola, EE, Bairoch, A, Barker, WC, Beck, S, Benson, DA, Berman, H, Cantor, C, Doubet, S, Hubbard, TJP, Jones, T. A., Kleywegt, G J, Kolaskar, AS, van Kuik, A, Lesk, A M, Mewes, H W, Neuhaus, D, Pfeiffer, F, Ten Eyck, LF, Simpson, RJ, Stoesser, G, Sussman, J L, Tateno, Y, Tsugita, A, Ulrich, EL, Vliegenthart, JFG, Abola, EE, Bairoch, A, Barker, WC, Beck, S, Benson, DA, Berman, H, Cantor, C, Doubet, S, Hubbard, TJP, Jones, T. A., Kleywegt, G J, Kolaskar, AS, van Kuik, A, Lesk, A M, Mewes, H W, Neuhaus, D, Pfeiffer, F, Ten Eyck, LF, Simpson, RJ, Stoesser, G, Sussman, J L, Tateno, Y, Tsugita, A, Ulrich, EL, and Vliegenthart, JFG

Published
2000

42. MIPS: analysis and annotation of genome information in 2007

Author

Mewes, H. W., primary, Dietmann, S., additional, Frishman, D., additional, Gregory, R., additional, Mannhaupt, G., additional, Mayer, K. F. X., additional, Munsterkotter, M., additional, Ruepp, A., additional, Spannagl, M., additional, Stumpflen, V., additional, and Rattei, T., additional

Published
2007
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43. CORUM: the comprehensive resource of mammalian protein complexes

Author

Ruepp, A., primary, Brauner, B., additional, Dunger-Kaltenbach, I., additional, Frishman, G., additional, Montrone, C., additional, Stransky, M., additional, Waegele, B., additional, Schmidt, T., additional, Doudieu, O. N., additional, Stumpflen, V., additional, and Mewes, H. W., additional

Published
2007
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44. PEDANT genome database: 10 years online

Author

Riley, M. L., primary, Schmidt, T., additional, Artamonova, I. I., additional, Wagner, C., additional, Volz, A., additional, Heumann, K., additional, Mewes, H.-W., additional, and Frishman, D., additional

Published
2007
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46. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana

Author

UCL - SST/ISV - Institut des sciences de la vie, Mayer, K., Schüller, C., Wambutt, R., Murphy, G., Volckaert, G., Pohl, T., Düsterhöft, A., Stiekema, W., Entian, K.-D., Terryn, N., Harris, B., Ansorge, W., Brandt, P., Grivell, L., Rieger, M., Weichselgartner, M., de Simone, V., Obermaier, B., Mache, R., Müller, M., Kreis, M., Delseny, M., Puigdomenech, P., Watson, M., Schmidtheini, T., Reichert, B., Portatelle, D., Perez-Alonso, M., Boutry, Marc, Bancroft, I., Vos, P., Hoheisel, J., Zimmermann, W., Wedler, H., Ridley, P., Langham, S.-A., McCullagh, B., Bilham, L., Robben, J., Van der Schueren, J., Grymonprez, B., Chuang, Y.-J., Vandenbussche, F., Braeken, M., Weltjens, I., Voet, M., Bastiaens, I., Aert, R., Defoor, E., Weitzenegger, T., Bothe, G., Ramsperger, U., Hilbert, H., Braun, M., Holzer, E., Brandt, A., Peters, S., van Staveren, M., Dirkse, W., Mooijman, P., Lankhorst, R. Klein, Rose, M., Hauf, J., Kötter, P., Berneiser, S., Hempel, S., Feldpausch, M., Lamberth, S., Van den Daele, H., De Keyser, A., Buysshaert, C., Gielen, J., Villarroel, R., De Clercq, R., Van Montagu, M., Rogers, J., Cronin, A., Quail, M., Bray-Allen, S., Clark, L., Doggett, J., Hall, S., Kay, M., Lennard, N., McLay, K., Mayes, R., Pettett, A., Rajandream, M.-A., Lyne, M., Benes, V., Rechmann, S., Borkova, D., Blöcker, H., Scharfe, M., Grimm, M., Löhnert, T.-H., Dose, S., de Haan, M., Maarse, A., Schäfer, M., Müller-Auer, S., Gabel, C., Fuchs, M., Fartmann, B., Granderath, K., Dauner, D., Herzl, A., Neumann, S., Argiriou, A., Vitale, D., Liguori, R., Piravandi, E., Massenet, O., Quigley, F., Clabauld, G., Mündlein, A., Felber, R., Schnabl, S., Hiller, R., Schmidt, W., Lecharny, A., Aubourg, S., Chefdor, F., Cooke, R., Berger, C., Montfort, A., Casacuberta, E., Gibbons, T., Weber, N., Vandenbol, M., Bargues, M., Terol, J., Torres, A., Perez-Perez, A., Purnelle, B., Bent, E., Johnson, S., Tacon, D., Jesse, T., Heijnen, L., Schwarz, S., Scholler, P., Heber, S., Francs, P., Bielke, C., Frishman, D., Haase, D., Lemcke, K., Mewes, H. W., Stocker, S., Zaccaria, P., Wilson, R. K., de la Bastide, M., Habermann, K., Parnell, L., Dedhia, N., Gnoj, L., Schutz, K., Huang, E., Spiegel, L., Sehkon, M., Murray, J., Sheet, P., Cordes, M., Abu-Threideh, J., Stoneking, T., Kalicki, J., Graves, T., Harmon, G., Edwards, J., Latreille, P., Courtney, L., Cloud, J., Abbott, A., Scott, K., Johnson, D., Minx, P., Bentley, D., Fulton, B., Miller, N., Greco, T., Kemp, K., Kramer, J., Fulton, L., Mardis, E., Dante, M., Pepin, K., Hillier, L., Nelson, J., Spieth, J., Ryan, E., Andrews, S., Geisel, C., Layman, D., Du, H., Ali, J., Berghoff, A., Jones, K., Drone, K., Cotton, M., Joshu, C., Antonoiu, B., Zidanic, M., Strong, C., Sun, H., Lamar, B., Yordan, C., Ma, P., Zhong, J., Preston, R., Vil, D., Shekher, M., Matero, A., Shah, R., Swaby, I'K., O'Shaughnessy, A., Rodriguez, M., Hoffman, J., Till, S., Granat, S., Shohdy, N., Hasegawa, A., Hameed, A., Lodhi, M., Johnson, A., Chen, E., Marra, M., Martienssen, R., McCombie, W. R., UCL - SST/ISV - Institut des sciences de la vie, Mayer, K., Schüller, C., Wambutt, R., Murphy, G., Volckaert, G., Pohl, T., Düsterhöft, A., Stiekema, W., Entian, K.-D., Terryn, N., Harris, B., Ansorge, W., Brandt, P., Grivell, L., Rieger, M., Weichselgartner, M., de Simone, V., Obermaier, B., Mache, R., Müller, M., Kreis, M., Delseny, M., Puigdomenech, P., Watson, M., Schmidtheini, T., Reichert, B., Portatelle, D., Perez-Alonso, M., Boutry, Marc, Bancroft, I., Vos, P., Hoheisel, J., Zimmermann, W., Wedler, H., Ridley, P., Langham, S.-A., McCullagh, B., Bilham, L., Robben, J., Van der Schueren, J., Grymonprez, B., Chuang, Y.-J., Vandenbussche, F., Braeken, M., Weltjens, I., Voet, M., Bastiaens, I., Aert, R., Defoor, E., Weitzenegger, T., Bothe, G., Ramsperger, U., Hilbert, H., Braun, M., Holzer, E., Brandt, A., Peters, S., van Staveren, M., Dirkse, W., Mooijman, P., Lankhorst, R. Klein, Rose, M., Hauf, J., Kötter, P., Berneiser, S., Hempel, S., Feldpausch, M., Lamberth, S., Van den Daele, H., De Keyser, A., Buysshaert, C., Gielen, J., Villarroel, R., De Clercq, R., Van Montagu, M., Rogers, J., Cronin, A., Quail, M., Bray-Allen, S., Clark, L., Doggett, J., Hall, S., Kay, M., Lennard, N., McLay, K., Mayes, R., Pettett, A., Rajandream, M.-A., Lyne, M., Benes, V., Rechmann, S., Borkova, D., Blöcker, H., Scharfe, M., Grimm, M., Löhnert, T.-H., Dose, S., de Haan, M., Maarse, A., Schäfer, M., Müller-Auer, S., Gabel, C., Fuchs, M., Fartmann, B., Granderath, K., Dauner, D., Herzl, A., Neumann, S., Argiriou, A., Vitale, D., Liguori, R., Piravandi, E., Massenet, O., Quigley, F., Clabauld, G., Mündlein, A., Felber, R., Schnabl, S., Hiller, R., Schmidt, W., Lecharny, A., Aubourg, S., Chefdor, F., Cooke, R., Berger, C., Montfort, A., Casacuberta, E., Gibbons, T., Weber, N., Vandenbol, M., Bargues, M., Terol, J., Torres, A., Perez-Perez, A., Purnelle, B., Bent, E., Johnson, S., Tacon, D., Jesse, T., Heijnen, L., Schwarz, S., Scholler, P., Heber, S., Francs, P., Bielke, C., Frishman, D., Haase, D., Lemcke, K., Mewes, H. W., Stocker, S., Zaccaria, P., Wilson, R. K., de la Bastide, M., Habermann, K., Parnell, L., Dedhia, N., Gnoj, L., Schutz, K., Huang, E., Spiegel, L., Sehkon, M., Murray, J., Sheet, P., Cordes, M., Abu-Threideh, J., Stoneking, T., Kalicki, J., Graves, T., Harmon, G., Edwards, J., Latreille, P., Courtney, L., Cloud, J., Abbott, A., Scott, K., Johnson, D., Minx, P., Bentley, D., Fulton, B., Miller, N., Greco, T., Kemp, K., Kramer, J., Fulton, L., Mardis, E., Dante, M., Pepin, K., Hillier, L., Nelson, J., Spieth, J., Ryan, E., Andrews, S., Geisel, C., Layman, D., Du, H., Ali, J., Berghoff, A., Jones, K., Drone, K., Cotton, M., Joshu, C., Antonoiu, B., Zidanic, M., Strong, C., Sun, H., Lamar, B., Yordan, C., Ma, P., Zhong, J., Preston, R., Vil, D., Shekher, M., Matero, A., Shah, R., Swaby, I'K., O'Shaughnessy, A., Rodriguez, M., Hoffman, J., Till, S., Granat, S., Shohdy, N., Hasegawa, A., Hameed, A., Lodhi, M., Johnson, A., Chen, E., Marra, M., Martienssen, R., and McCombie, W. R.

Abstract

The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996. Here we report one of the first milestones of this project, the sequence of chromosome 4. Analysis of 17.38 megabases of unique sequence, representing about 17% of the genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements. Heterochromatic regions surrounding the putative centromere, which has not yet been completely sequenced, are characterized by an increased frequency of a variety of repeats, new repeats, reduced recombination, lowered gene density and lowered gene expression. Roughly 60% of the predicted protein-coding genes have been functionally characterized on the basis of their homology to known genes. Many genes encode predicted proteins that are homologous to human and Caenorhabditis elegans proteins.

Published
1999

48. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.

Author

Philippsen, Peter, Kleine, K, Pöhlmann, R, Düsterhöft, A, Hamberg, K, Hegemann, Johannes H, Obermaier, B, Urrestarazu, Luis, Aert, R, Albermann, K, Altmann, R, André, Bruno, Baladron, V, Ballesta, J P, Bécam, A M, Beinhauer, J, Boskovic, J, Buitrago, M J, Bussereau, F, Coster, F, Crouzet, M, D'Angelo, Maria Grazia, Dal Pero, F, De Antoni, A, Del Rey, F, Doignon, F, Domdey, H, Dubois, Evelyne, Fiedler, Thomas, Fleig, U, Floeth, M, Fritz, C, Gaillardin, C, Garcia-Cantalejo, J M, Glansdorff, N N, Goffeau, A, Gueldener, U, Herbert, C, Heumann, K, Heuss-Neitzel, D, Hilbert, H, Hinni, K, Iraqui Houssaini, Ismaïl, Jacquet, Maud, Jiménez, Ana I., Jonniaux, J L, Karpfinger, L, Lanfranchi, G, Lepingle, A, Levesque, H, Lyck, R, Maftahi, M, Mallet, L, Maurer, Konrad, Messenguy, Francine, Mewes, H W, Mösti, D, Nasr, F, Nicaud, Jean Marc, Niedenthal, R K, Pandolfo, D, Pierard, Annie, Piravandi, E, Planta, R J, Pohl, T M, Purnelle, B, Rebischung, C, Remacha, M, Revuelta, Jose L, Rinke, M, Saiz, J E, Sartorello, F, Scherens, Bart, Sen-Gupta, M, Soler-Mira, A, Urbanus, J H, Valle, Giorgio, Van Dyck, L, Verhasselt, P, Vierendeels, Fabienne, Vissers, Stephan, Voet, Marleen, Volckaert, Guido, Wach, A, Wambutt, R, Wedler, H, Zollner, A, Hani, J, Philippsen, Peter, Kleine, K, Pöhlmann, R, Düsterhöft, A, Hamberg, K, Hegemann, Johannes H, Obermaier, B, Urrestarazu, Luis, Aert, R, Albermann, K, Altmann, R, André, Bruno, Baladron, V, Ballesta, J P, Bécam, A M, Beinhauer, J, Boskovic, J, Buitrago, M J, Bussereau, F, Coster, F, Crouzet, M, D'Angelo, Maria Grazia, Dal Pero, F, De Antoni, A, Del Rey, F, Doignon, F, Domdey, H, Dubois, Evelyne, Fiedler, Thomas, Fleig, U, Floeth, M, Fritz, C, Gaillardin, C, Garcia-Cantalejo, J M, Glansdorff, N N, Goffeau, A, Gueldener, U, Herbert, C, Heumann, K, Heuss-Neitzel, D, Hilbert, H, Hinni, K, Iraqui Houssaini, Ismaïl, Jacquet, Maud, Jiménez, Ana I., Jonniaux, J L, Karpfinger, L, Lanfranchi, G, Lepingle, A, Levesque, H, Lyck, R, Maftahi, M, Mallet, L, Maurer, Konrad, Messenguy, Francine, Mewes, H W, Mösti, D, Nasr, F, Nicaud, Jean Marc, Niedenthal, R K, Pandolfo, D, Pierard, Annie, Piravandi, E, Planta, R J, Pohl, T M, Purnelle, B, Rebischung, C, Remacha, M, Revuelta, Jose L, Rinke, M, Saiz, J E, Sartorello, F, Scherens, Bart, Sen-Gupta, M, Soler-Mira, A, Urbanus, J H, Valle, Giorgio, Van Dyck, L, Verhasselt, P, Vierendeels, Fabienne, Vissers, Stephan, Voet, Marleen, Volckaert, Guido, Wach, A, Wambutt, R, Wedler, H, Zollner, A, and Hani, J

Abstract

In 1992 we started assembling an ordered library of cosmid clones from chromosome XIV of the yeast Saccharomyces cerevisiae. At that time, only 49 genes were known to be located on this chromosome and we estimated that 80% to 90% of its genes were yet to be discovered. In 1993, a team of 20 European laboratories began the systematic sequence analysis of chromosome XIV. The completed and intensively checked final sequence of 784,328 base pairs was released in April, 1996. Substantial parts had been published before or had previously been made available on request. The sequence contained 419 known or presumptive protein-coding genes, including two pseudogenes and three retrotransposons, 14 tRNA genes, and three small nuclear RNA genes. For 116 (30%) protein-coding sequences, one or more structural homologues were identified elsewhere in the yeast genome. Half of them belong to duplicated groups of 6-14 loosely linked genes, in most cases with conserved gene order and orientation (relaxed interchromosomal synteny). We have considered the possible evolutionary origins of this unexpected feature of yeast genome organization., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
1997

49. The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.

Author

Johnston, Mark, Hillier, L, Riles, Linda, Albermann, K, André, Bruno, Ansorge, W., Benes, V., Bruckner, M., Delius, Heike, Dubois, Evelyne, Düsterhöft, A, Entian, Karl-Dieter, Floeth, M, Goffeau, A, Hebling, U, Heumann, K, Heuss-Neitzel, D, Hilbert, H, Hilger, F, Kleine, K, Kötter, Peter, Louis, Edouard, Messenguy, Francine, Mewes, H W, Hoheisel, J D, Johnston, Mark, Hillier, L, Riles, Linda, Albermann, K, André, Bruno, Ansorge, W., Benes, V., Bruckner, M., Delius, Heike, Dubois, Evelyne, Düsterhöft, A, Entian, Karl-Dieter, Floeth, M, Goffeau, A, Hebling, U, Heumann, K, Heuss-Neitzel, D, Hilbert, H, Hilger, F, Kleine, K, Kötter, Peter, Louis, Edouard, Messenguy, Francine, Mewes, H W, and Hoheisel, J D

Abstract

The yeast Saccharomyces cerevisiae is the pre-eminent organism for the study of basic functions of eukaryotic cells. All of the genes of this simple eukaryotic cell have recently been revealed by an international collaborative effort to determine the complete DNA sequence of its nuclear genome. Here we describe some of the features of chromosome XII., Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
1997

50. Life with 6000 genes.

Author

UCL, Goffeau, André, Barrell, B G, Bussey, H, Davis, R W, Dujon, B., Feldmann, H., Galibert, F, Hoheisel, J D, Jacq, C., Johnston, M, Louis, E J, Mewes, H W, Murakami, Y, Philippsen, P, Tettelin, H, Oliver, S G, UCL, Goffeau, André, Barrell, B G, Bussey, H, Davis, R W, Dujon, B., Feldmann, H., Galibert, F, Hoheisel, J D, Jacq, C., Johnston, M, Louis, E J, Mewes, H W, Murakami, Y, Philippsen, P, Tettelin, H, and Oliver, S G

Abstract

The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

Published
1996

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