Search

Your search keyword '"Meuth, Sven G."' showing total 2,370 results
Start Over Author "Meuth, Sven G."
2,370 results on '"Meuth, Sven G."'

3. Preventing long-term disability in CIDP: the role of timely diagnosis and treatment monitoring in a multicenter CIDP cohort

Author

Quint, Paula, Schroeter, Christina B., Kohle, Felix, Öztürk, Menekse, Meisel, Andreas, Tamburrino, Giuliano, Mausberg, Anne K., Szepanowski, Fabian, Afzali, Ali Maisam, Fischer, Katinka, Nelke, Christopher, Räuber, Saskia, Voth, Jan, Masanneck, Lars, Willison, Alice, Vogelsang, Anna, Hemmer, Bernhard, Berthele, Achim, Schroeter, Michael, Hartung, Hans-Peter, Pawlitzki, Marc, Schreiber, Stefanie, Stettner, Mark, Maus, Uwe, Meuth, Sven G., Stascheit, Frauke, and Ruck, Tobias

Published
2024
Full Text
View/download PDF

9. Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies

Author

Räuber, Saskia, Schulte-Mecklenbeck, Andreas, Willison, Alice, Hagler, Ramona, Jonas, Marius, Pul, Duygu, Masanneck, Lars, Schroeter, Christina B., Golombeck, Kristin S., Lichtenberg, Stefanie, Strippel, Christine, Gallus, Marco, Dik, Andre, Kerkhoff, Ruth, Barman, Sumanta, Weber, Katharina J., Kovac, Stjepana, Korsen, Melanie, Pawlitzki, Marc, Goebels, Norbert, Ruck, Tobias, Gross, Catharina C., Paulus, Werner, Reifenberger, Guido, Hanke, Michael, Grauer, Oliver, Rapp, Marion, Sabel, Michael, Wiendl, Heinz, Meuth, Sven G., and Melzer, Nico

Published
2024
Full Text
View/download PDF

10. Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy – a cross-sectional study

Author

Dörner, Marc, Tyndall, Anthony, Hainc, Nicolin, von Känel, Roland, Neumann, Katja, Euler, Sebastian, Schreiber, Frank, Arndt, Philipp, Fuchs, Erelle, Garz, Cornelia, Glanz, Wenzel, Butryn, Michaela, Schulze, Jan Ben, Schiebler, Sarah Lavinia Florence, John, Anna-Charlotte, Hildebrand, Annkatrin, Hofmann, Andreas B., Machetanz, Lena, Kirchebner, Johannes, Tacik, Pawel, Grimm, Alexander, Jansen, Robin, Pawlitzki, Marc, Henneicke, Solveig, Bernal, Jose, Perosa, Valentina, Düzel, Emrah, Meuth, Sven G., Vielhaber, Stefan, Mattern, Hendrik, and Schreiber, Stefanie

Published
2024
Full Text
View/download PDF

11. Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

Author

Krämer, Julia, Balloff, Carolin, Weise, Margit, Koska, Valeria, Uthmeier, Yannik, Esderts, Isabell, Nguyen-Minh, Mai, Zimmerhof, Moritz, Hartmann, Alex, Dietrich, Michael, Ingwersen, Jens, Lee, John-Ih, Havla, Joachim, Kümpfel, Tania, Kerschensteiner, Martin, Häußler, Vivien, Heesen, Christoph, Stellmann, Jan-Patrick, Zimmermann, Hanna G., Oertel, Frederike C., Ringelstein, Marius, Brandt, Alexander U., Paul, Friedemann, Aktas, Orhan, Hartung, Hans-Peter, Wiendl, Heinz, Meuth, Sven G., and Albrecht, Philipp

Published
2024
Full Text
View/download PDF

16. Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis

Author

Schroeter, Christina B., Nelke, Christopher, Stascheit, Frauke, Huntemann, Niklas, Preusse, Corinna, Dobelmann, Vera, Theissen, Lukas, Pawlitzki, Marc, Räuber, Saskia, Willison, Alice, Vogelsang, Anna, Marina, Adela Della, Hartung, Hans-Peter, Melzer, Nico, Konen, Felix F., Skripuletz, Thomas, Hentschel, Andreas, König, Simone, Schweizer, Michaela, Stühler, Kai, Poschmann, Gereon, Roos, Andreas, Stenzel, Werner, Meisel, Andreas, Meuth, Sven G., and Ruck, Tobias

Published
2024
Full Text
View/download PDF

18. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis

Author

Gallus, Marco, Roll, Wolfgang, Dik, Andre, Barca, Cristina, Zinnhardt, Bastian, Hicking, Gordon, Mueller, Christoph, Naik, Venu Narayanan, Anstötz, Max, Krämer, Julia, Rolfes, Leoni, Wachsmuth, Lydia, Pitsch, Julika, van Loo, Karen MJ, Räuber, Saskia, Okada, Hideho, Wimberley, Catriona, Strippel, Christine, Golombeck, Kristin S, Johnen, Andreas, Kovac, Stjepana, Groß, Catharina C, Backhaus, Philipp, Seifert, Robert, Lewerenz, Jan, Surges, Rainer, Elger, Christian E, Wiendl, Heinz, Ruck, Tobias, Becker, Albert J, Faber, Cornelius, Jacobs, Andreas H, Bauer, Jan, Meuth, Sven G, Schäfers, Michael, and Melzer, Nico

Subjects
Biomedical and Clinical Sciences, Immunology, Neurosciences, Biomedical Imaging, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Animals, Humans, Mice, Carrier Proteins, Inflammation, Limbic Encephalitis, Positron-Emission Tomography, Receptors, GABA
Abstract

Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients presents a clinical challenge, and novel noninvasive imaging biomarkers are urgently needed. Here, we demonstrate that visualization of the translocator protein (TSPO) with [18F]DPA-714-PET-MRI reveals pronounced microglia activation and reactive gliosis in the hippocampus and amygdala of patients suspected with CD8 T cell ALE, which correlates with FLAIR-MRI and EEG alterations. Back-translation into a preclinical mouse model of neuronal antigen-specific CD8 T cell-mediated ALE allowed us to corroborate our preliminary clinical findings. These translational data underline the potential of [18F]DPA-714-PET-MRI as a clinical molecular imaging method for the direct assessment of innate immunity in CD8 T cell-mediated ALE.

Published
2023

21. Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort

Author

Oertel, Frederike Cosima, Krämer, Julia, Motamedi, Seyedamirhosein, Keihani, Azeen, Zimmermann, Hanna G, Dimitriou, Nikolaos G, Condor-Montes, Shivany, Bereuter, Charlotte, Cordano, Christian, Abdelhak, Ahmed, Trip, Anand, Aktas, Orhan, Meuth, Sven G, Wiendl, Heinz, Ruprecht, Klemens, Bellmann-Strobl, Judith, Paul, Friedemann, Petzold, Axel, Brandt, Alexander U, Albrecht, Philipp, and Green, Ari J

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurodegenerative, Clinical Research, Multiple Sclerosis, Neurosciences, Eye Disease and Disorders of Vision, Brain Disorders, Autoimmune Disease, Eye, Neurological, Humans, Male, Evoked Potentials, Optic Neuritis, Prognosis, Retina, Retinal Ganglion Cells, Female, Adult, Middle Aged
Abstract

Background and objectivesWith the increasing use of visually evoked potentials (VEPs) as quantitative outcome parameters for myelin in clinical trials, an in-depth understanding of longitudinal VEP latency changes and their prognostic potential for subsequent neuronal loss will be required. In this longitudinal multicenter study, we evaluated the association and prognostic potential of VEP latency for retinal neurodegeneration, measured by optical coherence tomography (OCT), in relapsing-remitting MS (RRMS).MethodsWe included 293 eyes of 147 patients with RRMS (age [years, median ± SD] 36 ± 10, male sex 35%, F/U [years, median {IQR} 2.1 {1.5-3.9}]): 41 eyes had a history of optic neuritis (ON) ≥6 months before baseline (CHRONIC-ON), and 252 eyes had no history of ON (CHRONIC-NON). P100 latency (VEP), macular combined ganglion cell and inner plexiform layer volume (GCIPL), and peripapillary retinal nerve fiber layer thickness (pRNFL) (OCT) were quantified.ResultsP100 latency change over the first year predicted subsequent GCIPL loss (36 months) across the entire chronic cohort (p = 0.001) and in (and driven by) the CHRONIC-NON subset (p = 0.019) but not in the CHRONIC-ON subset (p = 0.680). P100 latency and pRNFL were correlated at baseline (CHRONIC-NON p = 0.004, CHRONIC-ON p < 0.001), but change in P100 latency and pRNFL were not correlated. P100 latency did not differ longitudinally between protocols or centers.DiscussionVEP in non-ON eyes seems to be a promising marker of demyelination in RRMS and of potential prognostic value for subsequent retinal ganglion cell loss. This study also provides evidence that VEP may be a useful and reliable biomarker for multicenter studies.

Published
2023

22. Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

Author

Kapell, Hannah, Fazio, Luca, Dyckow, Julia, Schwarz, Sophia, Cruz-Herranz, Andrés, Mayer, Christina, Campos, Joaquin, D´Este, Elisa, Möbius, Wiebke, Cordano, Christian, Pröbstel, Anne-Katrin, Gharagozloo, Marjan, Zulji, Amel, Naik, Venu Narayanan, Delank, Anna-Katharina, Cerina, Manuela, Müntefering, Thomas, Lerma-Martin, Celia, Sonner, Jana K, Sin, Jung H, Disse, Paul, Rychlik, Nicole, Sabeur, Khalida, Chavali, Manideep, Srivastava, Rajneesh, Heidenreich, Matthias, Fitzgerald, Kathryn C, Seebohm, Guiscard, Stadelmann, Christine, Hemmer, Bernhard, Platten, Michael, Jentsch, Thomas J, Engelhardt, Maren, Budde, Thomas, Nave, Klaus-Armin, Calabresi, Peter A, Friese, Manuel A, Green, Ari J, Acuna, Claudio, Rowitch, David H, Meuth, Sven G, and Schirmer, Lucas

Subjects
Neurosciences, Brain Disorders, Multiple Sclerosis, Autoimmune Disease, Neurodegenerative, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Mice, Animals, Humans, Ranvier's Nodes, Potassium, Neurons, Oligodendroglia, Encephalomyelitis, Autoimmune, Experimental, Inflammation, Multiple sclerosis, Neurodegeneration, Neuroscience, Potassium channels, Medical and Health Sciences, Immunology
Abstract

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic hyperexcitability. Axonal Kv7 (outward-rectifying) and oligodendroglial Kir4.1 (inward-rectifying) potassium channels have important roles in regulating neuronal excitability at and around the nodes of Ranvier. Here, we studied the spatial and functional relationship between neuronal Kv7 and oligodendroglial Kir4.1 channels and assessed the transcriptional and functional signatures of cortical and retinal projection neurons under physiological and inflammatory demyelinating conditions. We found that both channels became dysregulated in MS and experimental autoimmune encephalomyelitis (EAE), with Kir4.1 channels being chronically downregulated and Kv7 channel subunits being transiently upregulated during inflammatory demyelination. Further, we observed that pharmacological Kv7 channel opening with retigabine reduced neuronal hyperexcitability in human and EAE neurons, improved clinical EAE signs, and rescued neuronal pathology in oligodendrocyte-Kir4.1-deficient (OL-Kir4.1-deficient) mice. In summary, our findings indicate that neuron-OL compensatory interactions promoted resilience through Kv7 and Kir4.1 channels and identify pharmacological activation of nodal Kv7 channels as a neuroprotective strategy against inflammatory demyelination.

Published
2023

23. Safety experience with continued exposure to ofatumumab in patients with relapsing forms of multiple sclerosis for up to 3.5 years

Author

Hauser, Stephen L, Cross, Anne H, Winthrop, Kevin, Wiendl, Heinz, Nicholas, Jacqueline, Meuth, Sven G, Giacomini, Paul S, Saccà, Francesco, Mancione, Linda, Zielman, Ronald, Bagger, Morten, Gupta, Ayan Das, Häring, Dieter A, Jehl, Valentine, Kieseier, Bernd C, Pingili, Ratnakar, Stoneman, Dee, Su, Wendy, Willi, Roman, and Kappos, Ludwig

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Rare Diseases, Patient Safety, Infectious Diseases, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Antibodies, Monoclonal, Humanized, Humans, Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Ofatumumab, multiple sclerosis, antibodies, monoclonal, relapsing multiple sclerosis, safety, Neurosciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

BackgroundOfatumumab is approved for the treatment of relapsing multiple sclerosis (RMS). Ongoing safety reporting is crucial to understand its long-term benefit-risk profile.ObjectiveReport the safety and tolerability of ofatumumab in RMS after extended treatment up to 3.5 years.MethodsPatients completing ASCLEPIOS I/II (phase 3), APLIOS, or APOLITOS (phase 2) trials could enter ALITHIOS, a phase 3b, open-label, long-term safety study. We analyzed cumulative data of continuous ofatumumab treatment and of patients newly switched from teriflunomide.ResultsThe safety population had 1969 patients: 1292 continuously treated with ofatumumab (median time-at-risk 35.5 months, 3253 patient-years) and 677 newly switched (median time-at-risk 18.3 months, 986 patient-years). A total of 1650 patients (83.8%) had ⩾1 adverse events and 191 (9.7%) had ⩾1 serious adverse events. No opportunistic infections or progressive multifocal leukoencephalopathy events were identified; the risk of malignancies was low. Mean serum immunoglobulin (Ig) G levels remained stable. Mean IgM levels decreased but remained above the lower limit of normal in most. Serious infection incidence was low; decreased Ig levels were not associated with serious infections.ConclusionIn patients with up to 3.5 years' exposure, ofatumumab was well tolerated, with no new safety risks identified. These findings, with its established effectiveness, support a favorable benefit-risk profile of ofatumumab in RMS.

Published
2022

28. Identification of disease phenotypes in acetylcholine receptor-antibody myasthenia gravis using proteomics-based consensus clustering

Author

Nelke, Christopher, Schroeter, Christina B., Barman, Sumanta, Stascheit, Frauke, Masanneck, Lars, Theissen, Lukas, Huntemann, Niklas, Walli, Sara, Cengiz, Derya, Dobelmann, Vera, Vogelsang, Anna, Pawlitzki, Marc, Räuber, Saskia, Konen, Felix F., Skripuletz, Thomas, Hartung, Hans-Peter, König, Simone, Roos, Andreas, Meisel, Andreas, Meuth, Sven G., and Ruck, Tobias

Published
2024
Full Text
View/download PDF

29. Concurrent gliomas in patients with multiple sclerosis

Author

Sahm, Katharina, Kessler, Tobias, Eisele, Philipp, Ratliff, Miriam, Sperk, Elena, König, Laila, Breckwoldt, Michael O., Seliger, Corinna, Mildenberger, Iris, Schrimpf, Daniel, Herold-Mende, Christel, Zeiner, Pia S., Tabatabai, Ghazaleh, Meuth, Sven G., Capper, David, Bendszus, Martin, von Deimling, Andreas, Wick, Wolfgang, Sahm, Felix, and Platten, Michael

Published
2023
Full Text
View/download PDF

30. Prevalence and prognostic value of neurological affections in hospitalized patients with moderate to severe COVID-19 based on objective assessments

Author

Balloff, Carolin, Bandlow, Carolina, Bernhard, Michael, Brandenburger, Timo, Bludau, Patricia, Elben, Saskia, Feldt, Torsten, Hartmann, Christian J., Heinen, Elisa, Ingwersen, Jens, Jansen, Corinna, Jensen, Björn-Erik O., Kindgen-Milles, Detlef, Luedde, Tom, Penner, Iris-Katharina, Slink, Isabel, Stramm, Kim, Telke, Ann-Kathrin, Timm, Jörg, Vetterkind, Lana, Vollmer, Christian, Wolff, Georg, Schnitzler, Alfons, Meuth, Sven G., Groiss, Stefan J., and Albrecht, Philipp

Published
2023
Full Text
View/download PDF

35. Classification of neurological diseases using multi-dimensional cerebrospinal fluid analysis

Author

Gross, Catharina C, Schulte-Mecklenbeck, Andreas, Madireddy, Lohith, Pawlitzki, Marc, Strippel, Christine, Räuber, Saskia, Krämer, Julia, Rolfes, Leoni, Ruck, Tobias, Beuker, Carolin, Schmidt-Pogoda, Antje, Lohmann, Lisa, Schneider-Hohendorf, Tilman, Hahn, Tim, Schwab, Nicholas, Minnerup, Jens, Melzer, Nico, Klotz, Luisa, Meuth, Sven G, Hörste, Gerd Meyer zu, Baranzini, Sergio E, and Wiendl, Heinz

Subjects
Autoimmune Disease, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Neurological, Inflammatory and immune system, Good Health and Well Being, Biomarkers, Cohort Studies, Diagnosis, Differential, Female, Humans, Inflammation Mediators, Male, Nervous System Diseases, Retrospective Studies, CNS autoimmunity, multiple sclerosis, differential diagnosis, CSF, immune profile, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Although CSF analysis routinely enables the diagnosis of neurological diseases, it is mainly used for the gross distinction between infectious, autoimmune inflammatory, and degenerative disorders of the CNS. To investigate, whether a multi-dimensional cellular blood and CSF characterization can support the diagnosis of clinically similar neurological diseases, we analysed 546 patients with autoimmune neuroinflammatory, degenerative, or vascular conditions in a cross-sectional retrospective study. By combining feature selection with dimensionality reduction and machine learning approaches we identified pan-disease parameters that were altered across all autoimmune neuroinflammatory CNS diseases and differentiated them from other neurological conditions and inter-autoimmunity classifiers that subdifferentiate variants of CNS-directed autoimmunity. Pan-disease as well as diseases-specific changes formed a continuum, reflecting clinical disease evolution. A validation cohort of 231 independent patients confirmed that combining multiple parameters into composite scores can assist the classification of neurological patients. Overall, we showed that the integrated analysis of blood and CSF parameters improves the differential diagnosis of neurological diseases, thereby facilitating early treatment decisions.

Published
2021

36. K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies

Author

Nelke, Christopher, Müntefering, Thomas, Cengiz, Derya, Theissen, Lukas, Dobelmann, Vera, Schroeter, Christina B., Block, Helena, Preuße, Corinna, Michels, Alexander P.E., Lichtenberg, Stefanie, Pawlitzki, Marc, Pfeuffer, Steffen, Huntemann, Niklas, Zarbock, Alexander, Briese, Thorben, Kittl, Christoph, Dittmayer, Carsten, Budde, Thomas, Lundberg, Ingrid E., Stenzel, Werner, Meuth, Sven G., and Ruck, Tobias

Published
2024
Full Text
View/download PDF

44. Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis.

Author

Schafflick, David, Xu, Chenling A, Hartlehnert, Maike, Cole, Michael, Schulte-Mecklenbeck, Andreas, Lautwein, Tobias, Wolbert, Jolien, Heming, Michael, Meuth, Sven G, Kuhlmann, Tanja, Gross, Catharina C, Wiendl, Heinz, Yosef, Nir, and Meyer Zu Horste, Gerd

Subjects
Animals, B-Lymphocytes, Blood Cells, Central Nervous System, Cerebrospinal Fluid, Encephalomyelitis, Autoimmune, Experimental, Gene Expression Profiling, Humans, Leukocytes, Mice, Multiple Sclerosis, Phenotype, Single-Cell Analysis, T-Lymphocyte Subsets, T-Lymphocytes, Helper-Inducer
Abstract

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains superficial. Here, using single cell transcriptomics, we identify a specific location-associated composition and transcriptome of CSF leukocytes. Multiple sclerosis (MS) - an autoimmune disease of the CNS - increases transcriptional diversity in blood, but increases cell type diversity in CSF including a higher abundance of cytotoxic phenotype T helper cells. An analytical approach, named cell set enrichment analysis (CSEA) identifies a cluster-independent increase of follicular (TFH) cells potentially driving the known expansion of B lineage cells in the CSF in MS. In mice, TFH cells accordingly promote B cell infiltration into the CNS and the severity of MS animal models. Immune mechanisms in MS are thus highly compartmentalized and indicate ongoing local T/B cell interaction.

Published
2020

50. Review and meta-analysis of neuropsychological findings in autoimmune limbic encephalitis with autoantibodies against LGI1, CASPR2, and GAD65 and their response to immunotherapy

Author

Mueller, Christoph, Elben, Saskia, Day, Gregory S., Alves, Pedro, Hebert, Julien, Tang-Wai, David F., Holtmann, Olga, Iorio, Raffaele, Perani, Daniela, Titulaer, Maarten J., Hansen, Niels, Bartsch, Thorsten, Johnen, Andreas, Illes, Zsolt, Borm, Leah, Willison, Alice G., Wiendl, Heinz, Meuth, Sven G., Kovac, Stjepana, Bölte, Jens, and Melzer, Nico

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results