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402 results on '"Meulenbelt, Jan"'

1. Cadmium

Author

Meulenbelt, Jan, Brent, Jeffrey, editor, Burkhart, Keith, editor, Dargan, Paul, editor, Hatten, Benjamin, editor, Megarbane, Bruno, editor, Palmer, Robert, editor, and White, Julian, editor

Published
2017
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21. A case series of xylometazoline overdose in children

Author

Van Velzen, Agnes G., Van Riel, Antoinette J.H.P., Hunault, Claudine, van Riemsdijk, Tessa E., de Vries, Irma, and Meulenbelt, Jan

Subjects
Xylometazoline -- Complications and side effects, Pediatric emergencies -- Case studies, Drunkenness (Criminal law) -- Case studies, Imidazole -- Complications and side effects, Drugs -- Overdose, Drugs -- Case studies, Environmental issues, Health, Pharmaceuticals and cosmetics industries
Published
2007

26. Nonaccidental endosulfan intoxication: a case report with toxicokinetic calculations and tissue concentrations

Author

Boereboom, Frans T.J., Dijk, Aalt van, Zoonen, Piet van, and Meulenbelt, Jan

Subjects
Insecticides -- Health aspects, Self-poisoning -- Case studies, Environmental issues, Health, Pharmaceuticals and cosmetics industries
Abstract

Case Report: A case of nonaccidental endosulfan intoxication in a previously healthy 43-year-old male patient is reported. On admission, the patient had few symptoms, but refractory seizures began I hour after ingestion. The patient died on the fourth day after admission showing clinical signs of cerebral herniation confirmed at autopsy. Blood, urine, and tissue samples were analyzed for [Alpha]-endosulfan, [Beta]-endosulfan, and endosulfan sulfate by capillary gas chromatography with electron capture detection. Concentration versus time data for endosulfan were fitted using the program MW/Pharm[R], assuming complete bioavailability although it is recognized that the bioavailability of endosulfan after ingestion may have been low and the calculated clearance was primarily due to redistribution. Hemoperfusion was shown to be ineffective., INTRODUCTION Endosulfan (1,4,5,6,7,7-hexachloro-5-norbornene-2,3-dimethanol cyclic sulfite [C.sub.9][H.sub.6][Cl.sub.6][O.sub.3]S; 406.95 daltons), a chlorinated hydrocarbon of the cyclodiene group is a nonsystemic contact insecticide and acaricide used for the control of various plant pests [...]

Published
1998

27. Evaluation of semi-generic PBTK modeling for emergency risk assessment after acute inhalation exposure to volatile hazardous chemicals

Author

Olie, J Daniël N, Bessems, Jos G, Clewell, Harvey J, Meulenbelt, Jan, Hunault, Claudine C, LS IRAS Tox KTX (Klinische toxicologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1, LS IRAS Tox KTX (Klinische toxicologie), Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA1

Subjects
Tetrachloroethylene, Environmental Engineering, Chemistry(all), Trichloroethylene, PBTK, Health, Toxicology and Mutagenesis, Xylenes, Research Support, Models, Biological, Hazardous Substances, 2-Propanol, Toxicology, chemistry.chemical_compound, Hazardous waste, Acute exposure, Journal Article, Humans, Environmental Chemistry, Non-U.S. Gov't, Styrene, Risk assessment, Inhalation exposure, Inhalation Exposure, Methylene Chloride, Ms excel, Research Support, Non-U.S. Gov't, Public Health, Environmental and Occupational Health, Benzene, General Medicine, General Chemistry, Pollution, Toxicokinetics, Emergency response, Models, Chemical, chemistry, Environmental chemistry, Emergency, Environmental science, Hazardous chemicals, Toluene
Abstract

BACKGROUND: Physiologically Based Toxicokinetic Models (PBTK) may facilitate emergency risk assessment after chemical incidents with inhalation exposure, but they are rarely used due to their relative complexity and skill requirements. We aimed to tackle this problem by evaluating a semi-generic PBTK model built in MS Excel for nine chemicals that are widely-used and often released in a chemical incident. MATERIAL & METHODS: The semi-generic PBTK model was used to predict blood concentration-time curves using inhalation exposure scenarios from human volunteer studies, case reports and hypothetical exposures at Emergency Response Planning Guideline, Level 3 (ERPG-3) levels.(2) Predictions using this model were compared with measured blood concentrations from volunteer studies or case reports, as well as blood concentrations predicted by chemical-specific models. The performances of the semi-generic model were evaluated on biological rationale, accuracy, and ease of use and range of application. RESULTS: Our results indicate that the semi-generic model can be easily used to predict blood levels for eight out of nine parent chemicals (dichloromethane, benzene, xylene, styrene, toluene, isopropanol trichloroethylene and tetrachloroethylene). However, for methanol, 2-propanol and dichloromethane the semi-generic model could not cope with the endogenous production of methanol and of acetone (being a metabolite of 2-propanol) nor could it simulate the formation of HbCO, which is one of the toxic end-points of dichloromethane. The model is easy and intuitive to use by people who are not so familiar with toxicokinetic models. CONCLUSION: A semi-generic PBTK modeling approach can be used as a 'quick-and-dirty' method to get a crude estimate of the exposure dose.

Published
2015

30. Intoxication following minor stabs from the spines of a porcupine fish

Author

van Gorcum, Teetske F., Janse, Max, Leenders, Marianne E.C., de Vries, Irma, and Meulenbelt, Jan

Subjects
Tetrodotoxin -- Influence, Tetrodotoxin -- Case studies, Environmental issues, Health, Pharmaceuticals and cosmetics industries
Abstract

We report an unusual intoxication by tetrodotoxin (TTX). A curator of an aquarium sustained minor punctures in his finger from the spines of a porcupine fish during an autopsy of a dead porcupine fish. He developed paresthesias, numbness, paresis, dizziness and headache. The death of the fish might have caused some autolysis, leading to increased availability of TTX. In combination with direct contact with the organ fluids, this probably led to TTX exposure via minor wounds. Keywords Porcupine fish; Puffer; Tetraodontiformes; Fugu; Diodonhystrix; Tetrodotoxin; Ttx; Tetrodotoxication; Intoxication, INTRODUCTION Tetrodotoxin (TTX) is a potent non-protein neurotoxin that is found in certain marine animals, such as puffer fish, porcupine fish, and blue-ringed octopuses. Intoxications with TTX (tetrodotoxication) occur with [...]

Published
2006

31. Cadmium

Author

Brent, Jeffrey, Meulenbelt, Jan, Brent, Jeffrey, and Meulenbelt, Jan

Published
2017

33. Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead

Author

LS IRAS Tox KTX (Klinische toxicologie), dIRAS RA-1, van Eijkeren, Jan C H, Olie, J Daniël N, Bradberry, Sally M, Vale, J Allister, De Vries, Irma, Clewell, Harvey J., Meulenbelt, Jan, Hunault, Claudine C, LS IRAS Tox KTX (Klinische toxicologie), dIRAS RA-1, van Eijkeren, Jan C H, Olie, J Daniël N, Bradberry, Sally M, Vale, J Allister, De Vries, Irma, Clewell, Harvey J., Meulenbelt, Jan, and Hunault, Claudine C

Published
2017

34. Cadmium

Author

NVIC, Brent, Jeffrey, Meulenbelt, Jan, NVIC, Brent, Jeffrey, and Meulenbelt, Jan

Published
2017

35. The need for ICU admission in intoxicated patients: a prediction model

Author

Medische Staf Intensive Care, Brain, Infection & Immunity, NVIC, Brandenburg, Raya, Brinkman, Sylvia, de Keizer, Nicolette F, Kesecioglu, Jozef, Meulenbelt, Jan, de Lange, Dylan W, Medische Staf Intensive Care, Brain, Infection & Immunity, NVIC, Brandenburg, Raya, Brinkman, Sylvia, de Keizer, Nicolette F, Kesecioglu, Jozef, Meulenbelt, Jan, and de Lange, Dylan W

Published
2017

36. An unusual cause of ventricular fibrillation

Author

Gerritsen, Karin GF, Meulenbelt, Jan, Spiering, Wilko, Kema, Ido P., Demir, Ayse, and Van Driel, Vincent Jhm

Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0140-6736(09)60514-6 Byline: Karin GF Gerritsen (a), Jan Meulenbelt (b), Wilko Spiering (c), Ido P Kema (e), Ayse Demir (f), Vincent JHM van Driel (d) Author Affiliation: (a) Department of Internal Medicine, University Medical Center of Utrecht, University of Utrecht, The Netherlands (b) Department of Intensive Care, University Medical Center of Utrecht, University of Utrecht, The Netherlands (c) Department of Vascular Medicine, University Medical Center of Utrecht, University of Utrecht, The Netherlands (d) Department of Cardiology, University Medical Center of Utrecht, University of Utrecht, The Netherlands (e) Department of Laboratory Medicine, University Medical Center of Groningen, University of Groningen, Groningen, The Netherlands (f) Department of Clinical Chemistry, Meander Medisch Centrum, Amersfoort, The Netherlands

Published
2009
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45. Ethylene glycol poisoning mimicking Snow White

Author

Dijk, Gert W van, Meulenbelt, Jan, Braam, G Branko, and Tobe, Tom J M

Subjects
Ethylene glycol -- Health aspects, Brain death -- Evaluation, Paralysis -- Medical examination, Death -- Proof and certification
Published
2002

46. TOXIC study: exposures and outcome of intoxicated patients visiting the emergency department

Author

Hondebrink, Laura, Rietjens, Saskia R., Van Den Hengel-Koot, Irma, Zandee, Bianka, Strik, Jeffrey, De Lange, Dylan W., Kaasjager, Karin A. H., Dekker, Douwe, Meulenbelt, Jan, Hondebrink, Laura, Rietjens, Saskia R., Van Den Hengel-Koot, Irma, Zandee, Bianka, Strik, Jeffrey, De Lange, Dylan W., Kaasjager, Karin A. H., Dekker, Douwe, and Meulenbelt, Jan

Published
2016

49. TOXIC study: exposures and outcome of intoxicated patients visiting the emergency department

Author

NVIC, Other research (not in main researchprogram), Medische Staf Intensive Care, MS Interne Geneeskunde, Circulatory Health, Hondebrink, Laura, Rietjens, Saskia R., Van Den Hengel-Koot, Irma, Zandee, Bianka, Strik, Jeffrey, De Lange, Dylan W., Kaasjager, Karin A. H., Dekker, Douwe, Meulenbelt, Jan, NVIC, Other research (not in main researchprogram), Medische Staf Intensive Care, MS Interne Geneeskunde, Circulatory Health, Hondebrink, Laura, Rietjens, Saskia R., Van Den Hengel-Koot, Irma, Zandee, Bianka, Strik, Jeffrey, De Lange, Dylan W., Kaasjager, Karin A. H., Dekker, Douwe, and Meulenbelt, Jan

Published
2016

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