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12. A Self-management Approach for Dietary Sodium Restriction in Patients With CKD: A Randomized Controlled Trial

Author

van der Boog, P.J.M., van Dijk, S., Navis, G.J., Humalda (project coordination), J.K., Klaassen, G., Meuleman, Y., Verschuur, L.C., Straathof, E.J.M., Blanson Henkemans, O.A., Bos, W.J.W., de Borst, M.H., Laverman, G.D., Otten, W., Vermeulen, K.M., de Vries, H., Humalda, Jelmer K., Klaassen, Gerald, de Vries, Hanne, Meuleman, Yvette, Verschuur, Lara C., Straathof, Elisabeth J.M., Laverman, Gozewijn D., Bos, Willem Jan W., van der Boog, Paul J.M., Vermeulen, Karin M., Blanson Henkemans, Olivier A., Otten, Wilma, de Borst, Martin H., van Dijk, Sandra, and Navis, Gerjan J.

Published
2020
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15. Kidney Disease: Improving Global Outcomes (KDIGO) Workshop on the Nurse’s Role in Managing the Symptoms of People Receiving Dialysis

Author

Bennett, Paul, Warren, Madeleine, Aydin, Zehra, Beige, Joachim, Bowes, Elaine, Cheung, Michael, Finderup, Jeanette, Gallego, Daniel, Hecking, Manfred, Hurst, Helen, King, Jennifer M., Kleophas, Werner, Liossatou, Anastasia, Martins, Pedro, Masià-Plana, Afra, Meuleman, Yvette, Neri, Luca, Noruišienė, Edita, Ortiz, John, Rix, Marianne, Stuard, Stefano, and Tsukamoto, Yusuke

Published
2025
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16. Health-related quality of life and symptom burden in patients on haemodialysis

Author

van Oevelen, Mathijs, Bonenkamp, Anna A, van Eck van der Sluijs, Anita, Bos, Willem Jan W, Douma, Caroline E, van Buren, Marjolijn, Meuleman, Yvette, Dekker, Friedo W, van Jaarsveld, Brigit C, Abrahams, Alferso C, Hoorn, Ewout, Severs, David, van Oevelen, Mathijs, Bonenkamp, Anna A, van Eck van der Sluijs, Anita, Bos, Willem Jan W, Douma, Caroline E, van Buren, Marjolijn, Meuleman, Yvette, Dekker, Friedo W, van Jaarsveld, Brigit C, Abrahams, Alferso C, Hoorn, Ewout, and Severs, David

Published
2024

21. Dealing with an uncertain future: a survey study on what patients with chronic kidney disease actually want to know.

Author

Milders, Jet, Ramspek, Chava L, Meuleman, Yvette, Bos, Willem Jan W, Michels, Wieneke M, Konijn, Wanda S, Dekker, Friedo W, and Diepen, Merel van

Subjects
RENAL replacement therapy, CHRONIC kidney failure, MEDICAL personnel, HEMODIALYSIS patients, PATIENT preferences
Abstract

Background Prognostic uncertainty is a recurring theme among patients with chronic kidney disease (CKD). We developed a survey to explore whether CKD patients want to know more about their future, and if so, which topics they prioritize. In addition, we explored differences between several subgroups. Methods A survey was constructed and tested in collaboration with the Dutch Kidney Patients Association. The survey consisted of three parts: (i) demographics, (ii) considerations about the future, and (iii) prognostic information. The survey was distributed among CKD patients (all stages) through patient associations and via healthcare professionals in two Dutch hospitals. Descriptive statistics were used to summarize the results. All results were stratified by population, sex, and age. Results A total of 163 patients (45 CKD, 26 dialysis, and 92 kidney transplantation) participated in the survey. The mean age was 63.9 (SD 12.0) and 48.5% was male. Most patients think about their future with CKD occasionally (56.4%) or often (35.0%). Nearly half of the patients (49.7%) discuss the future with their nephrologist, some (19.6%) do not but would like to, and 20 (15.3%) prefer not to. Most patients (73.6%) want more prognostic information, regardless of it being positive or negative. Key topics to receive prognostic information about were laboratory values, symptoms, and physical well-being. Dialysis patients prioritized mental over physical well-being. CKD patients without kidney replacement therapy (KRT) indicated thinking about, and discussing their future more regularly than KRT patients. Conclusions Patients with CKD contemplate their future regularly and express interest in receiving prognostic information on a variety of topics. One in five patients currently do not discuss their future with CKD with their nephrologist, despite wanting to do so. These findings underline the need to tailor prognostic information provision to patients' preferences, advocating more attention to this subject both in research and clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Nephrology‐tailored geriatric assessment as decision‐making tool in kidney failure.

Author

Berkhout‐Byrne, Noeleen C., Voorend, Carlijn G. N., Meuleman, Yvette, Mooijaart, Simon P., Brunsveld-Reinders, Anja H., Bos, Willem Jan W., and Van Buren, Marjolijn

Subjects
TREATMENT of chronic kidney failure, ELDER care, QUALITATIVE research, THERAPEUTICS, RENAL replacement therapy, RESEARCH funding, INTERVIEWING, DECISION making, HEMODIALYSIS, JUDGMENT sampling, NEPHROLOGY, THEMATIC analysis, GERIATRIC assessment, ATTITUDES of medical personnel, RESEARCH, QUALITY of life, RESEARCH methodology, PATIENT-professional relations, PATIENTS' attitudes, OLD age
Abstract

Background: Dialysis might not benefit all older patients with kidney failure, particularly those with multimorbid conditions and frailty. Patients' and healthcare professionals' awareness of the presence of geriatric impairments could improve outcomes by tailoring treatment plans and decisions for individual patients. Objective: We aimed to explore the perspectives of patients and healthcare professionals on nephrology‐tailored geriatric assessment to fuel decision‐making for treatment choices in older patients with kidney failure. Design: In an exploratory qualitative study using focus groups, participants discussed perspectives on the use and value of nephrology‐tailored geriatric assessment for the decision‐making process to start or forego dialysis. Participants and Measurements: Patients (n = 18) with kidney failure, caregivers (n = 4), and professionals (n = 25) were purposively sampled from 10 hospitals. Interviews were audio‐recorded, transcribed verbatim and inductively analysed using thematic analysis. Results: Three main themes emerged that supported or impeded decision‐making in kidney failure: (1) patient psycho‐social situation; (2) patient‐related factors on modality choice; (3) organisation of health care. Patients reported feeling vulnerable due to multiple chronic conditions, old age, experienced losses in life and their willingness to trade longevity for quality of life. Professionals recognised the added value of nephrology‐tailored geriatric assessment in three major themes: (i) facilitating continual holistic assessment, (ii) filling the knowledge gap, and (iii) uncovering important patient characteristics. Conclusions: nephrology‐tailored geriatric assessment was perceived as a valuable tool to identify geriatric impairments in older patients with kidney failure. Integration of its outcomes can facilitate a more holistic approach to inform choices and decisions about kidney replacement therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Sodium Restriction in Patients With CKD: A Randomized Controlled Trial of Self-management Support

Author

van Dijk, Sandra, Meuleman, Yvette, Dekker, Friedo W., Hoekstra, Tiny, Navis, Gerjan, Vogt, Liffert, van der Boog, Paul J.M., Bos, Willem Jan W., van Montfrans, Gert A., Boeschoten, Elisabeth W., Verduijn, Marion, ten Brinke, Lucia, Spijker, Anke, Kwakernaak, Arjan J., Humalda, Jelmer K., van Hirtum, Tonnie, Bokelaar, Robin, Loos, Marie-Louise, Bakker-Edink, Anke, Poot, Charlotte, Ciere, Yvette, Zwaard, Sophie, Veldscholte, Glenn, Heuveling, Lara, Storm, Marjolein, and Prantl, Karen

Published
2017
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25. Health-related quality of life and symptom burden in patients on haemodialysis.

Author

Oevelen, Mathijs van, Bonenkamp, Anna A, Sluijs, Anita van Eck van der, Bos, Willem Jan W, Douma, Caroline E, Buren, Marjolijn van, Meuleman, Yvette, Dekker, Friedo W, Jaarsveld, Brigit C van, Abrahams, Alferso C, and group, the DOMESTICO study

Subjects
SYMPTOM burden, QUALITY of life, HEMODIALYSIS patients, OLDER patients, PATIENTS' attitudes
Abstract

Background Patients on haemodialysis (HD) generally experience poor health-related quality of life (HRQoL) and a broad range of physical and mental symptoms, but it is unknown whether this differs between younger and older patients. We aimed to describe the trajectories of HRQoL and symptom burden of patients <70 and ≥70 years old and to assess the impact of symptom burden on HRQoL. Methods In incident Dutch HD patients, HRQoL and symptoms were measured with the 12-item Short Form Health Survey and Dialysis Symptom Index. We used linear mixed models for examining the trajectories of HRQoL and symptom burden during the first year of dialysis and linear regression for the impact of symptom burden on HRQoL. Results In 774 patients, the trajectories of physical HRQoL, mental HRQoL and symptom burden were stable during the first year of dialysis. Compared with patients <70 years of age, patients ≥70 years reported similar physical HRQoL {mean difference −0.61 [95% confidence interval (CI) −1.86–0.63]}, better mental HRQoL [1.77 (95% CI 0.54–3.01)] and lower symptom burden [−2.38 (95% CI −5.08–0.32)]. With increasing symptom burden, physical HRQoL declined more in older than in younger patients (β = −0.287 versus −0.189, respectively; P -value for interaction = .007). For mental HRQoL, this decrease was similar in both age groups (β = −0.295 versus −0.288, P  = .847). Conclusion Older HD patients generally experience a better mental HRQoL and a (non-statistically significant) lower symptom burden compared with younger patients. Their physical HRQoL declines more rapidly with increasing symptom burden. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Perceived Sodium Reduction Barriers Among Patients with Chronic Kidney Disease: Which Barriers Are Important and Which Patients Experience Barriers?

Author

Meuleman, Yvette, Hoekstra, Tiny, Dekker, Friedo W., van der Boog, Paul J. M., van Dijk, Sandra, van Dijk, Sandra, Meuleman, Yvette, Dekker, Friedo W., Hoekstra, Tiny, Navis, Gerjan, Vogt, Liffert, van der Boog, Paul J. M., Bos, Willem Jan W., van Montfrans, Gert A., Boeschoten, Elisabeth W., Verduijn, Marion, ten Brinke, Lucia, Heuveling, Lara, Storm, Marjolein, Prantl, Karen, Spijker, Anke, Kwakernaak, Arjan J., Humalda, Jelmer K., van Hirtum, Tonnie, Bokelaar, Robin, Loos, Marie-Louise, Bakker-Edink, Anke, Poot, Charlotte, Ciere, Yvette, Zwaard, Sophie, Veldscholte, Glenn, and The ESMO study group

Published
2017
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27. #6847 HEALTH-RELATED QUALITY OF LIFE AND SYMPTOM BURDEN IN YOUNGER AND OLDER HAEMODIALYSIS PATIENTS: A PROSPECTIVE COHORT STUDY

Author

Van Oevelen, Mathijs, primary, Bonenkamp, Anna, additional, van der Sluijs, Anita van Eck, additional, Bos, Willem Jan W, additional, Douma, Caroline, additional, van Buren, Marjolijn, additional, Meuleman, Yvette, additional, Dekker, Friedo W, additional, Van Jaarsveld, Brigit, additional, and Abrahams, Alferso C, additional

Published
2023
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29. Facing the challenges of PROM implementation in Dutch dialysis care:Patients' and professionals' perspectives

Author

Sipma, Wim S., de Jong, Margriet F.C., Meuleman, Yvette, Hemmelder, Marc H., Ahaus, Kees C.T.B., Sipma, Wim S., de Jong, Margriet F.C., Meuleman, Yvette, Hemmelder, Marc H., and Ahaus, Kees C.T.B.

Abstract

BACKGROUND: Patient Reported Outcome Measures (PROMs) are increasingly used in routine clinical practice to facilitate patients in sharing and discussing health-related topics with their clinician. This study focuses on the implementation experiences of healthcare professionals and patients during the early implementation phase of the newly developed Dutch set of dialysis PROMs and aims to understand the process of early implementation of PROMs from the users' perspectives. METHODS: This is a qualitative study among healthcare professionals (physicians and nursing staff: n = 13) and patients (n = 14) of which 12 were receiving haemodialysis and 2 peritoneal dialysis. Semi-structured interviews were used to understand the barriers and facilitators that both professionals and patients encounter when starting to implement PROMs. RESULTS: The early PROM implementation process is influenced by a variety of factors that we divided into barriers and facilitators. We identified four barriers: patient´s indifference to PROMs, scepticism on the benefits of aggregated PROM data, the limited treatment options open to doctors and organizational issues such as mergers, organizational problems and renovations. We also describe four facilitators: professional involvement and patient support, a growing understanding of the use of PROMs during the implementation, quick gains from using PROMs such as receiving instant feedback and a clear ambition on patient care such as a shared view on patient involvement and management support. CONCLUSIONS: In this qualitative study carried out during the early implementation phase of the Dutch dialysis PROM set, we found that patients did not yet consider the PROM set to be a useful additional tool to share information with their doctor. This was despite the professionals' primary reason for using PROMs being to improve patient-doctor communication. Furthermore, the perceived lack of intervention options was frustrating for some of the professi

Published
2023

34. Effect of residual kidney function and dialysis adequacy on chronic pruritus in dialysis patients

Author

Lengton, Robin, van der Willik, Esmee M, de Rooij, Esther N M, Meuleman, Yvette, Cessie, Saskia Le, Michels, Wieneke M, Hemmelder, Marc, Dekker, Friedo W, Hoogeveen, Ellen K, Interne Geneeskunde, MUMC+: MA Nefrologie (9), and RS: Carim - V02 Hypertension and target organ damage

Subjects
Transplantation, Nephrology
Abstract

Background Chronic kidney disease–associated pruritus (CKD-aP) is common in dialysis patients, and is associated with lower quality of life and increased risk of death. We investigated the association between residual estimated glomerular filtration rate (eGFR), dialysis adequacy or serum phosphate level and CKD-aP in incident dialysis patients. Methods A total of 1256 incident hemodialysis (HD) and 670 peritoneal dialysis (PD) patients (>18 years) from the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD) study were included (1997–2007) and followed until death, transplantation or a maximum of 10 years. CKD-aP was measured using a single item of the Kidney Disease Quality of Life Instrument-36. The associations were studied by logistic and linear regression analyses, adjusted for potential baseline confounders. Results At baseline mean (standard deviation) age was 60 (16) years, 62% were men and median (interquartile range) residual eGFR was 3.4 (1.7; 5.3) mL/min/1.73 m2. The prevalence of CKD-aP (∼70%) was similar in HD and PD. It was observed that 12 months after starting dialysis (after multivariable adjustment) each 1 mL/min/1.73 m2 higher residual eGFR, one unit higher total weekly Kt/V, or 1 mmol/L lower serum phosphate level was associated with lower burden of CKD-aP in HD and PD patients of –0.05 (95% CI –0.09; –0.02) and –0.09 (95% CI –0.13; –0.05), –0.15 (95% CI –0.26; –0.05) and –0.35 (95% CI –0.54; –0.16), and of –0.34 (95%CI: –0.51; –0.17) and –0.45 (95%CI: –0.71; –0.19), respectively. We found no association between dialysis Kt/V and CKD-aP. Conclusions Higher residual eGFR and lower serum phosphate level, but not the dialysis dose, were related with lower burden of CKD-aP in dialysis patients.

Published
2023

36. Symptom Burden before and after Dialysis Initiation in Older Patients

Author

de Rooij, Esther N.M., primary, Meuleman, Yvette, additional, de Fijter, Johan W., additional, Jager, Kitty J., additional, Chesnaye, Nicholas C., additional, Evans, Marie, additional, Caskey, Fergus J., additional, Torino, Claudia, additional, Porto, Gaetana, additional, Szymczak, Maciej, additional, Drechsler, Christiane, additional, Wanner, Christoph, additional, Dekker, Friedo W., additional, and Hoogeveen, Ellen K., additional

Published
2022
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40. Validity and reliability of the Patient-Reported Outcomes Measurement Information System (PROMIS®) using computerized adaptive testing in patients with advanced chronic kidney disease

Author

van der Willik, Esmee M, primary, van Breda, Fenna, additional, van Jaarsveld, Brigit C, additional, van de Putte, Marlon, additional, Jetten, Isabelle W, additional, Dekker, Friedo W, additional, Meuleman, Yvette, additional, van Ittersum, Frans J, additional, and Terwee, Caroline B, additional

Published
2022
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41. Quality of Life before and after the Start of Dialysis in Older Patients

Author

de Rooij, Esther N.M., primary, Meuleman, Yvette, additional, de Fijter, Johan W., additional, Le Cessie, Saskia, additional, Jager, Kitty J., additional, Chesnaye, Nicholas C., additional, Evans, Marie, additional, Pagels, Agneta A., additional, Caskey, Fergus J., additional, Torino, Claudia, additional, Porto, Gaetana, additional, Szymczak, Maciej, additional, Drechsler, Christiane, additional, Wanner, Christoph, additional, Dekker, Friedo W., additional, and Hoogeveen, Ellen K., additional

Published
2022
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42. Associations between depressive symptoms and disease progression in older patients with chronic kidney disease:Results of the EQUAL study

Author

Eveleens Maarse, Boukje C., Chesnaye, Nicholas C., Schouten, Robbert, Michels, Wieneke M., Bos, Willem Jan W., Szymczak, MacIej, Krajewska, Magdalena, Evans, Marie, Heimburger, Olof, Caskey, Fergus J., Wanner, Christoph, Jager, Kitty J., Dekker, Friedo W., Meuleman, Yvette, Eveleens Maarse, Boukje C., Chesnaye, Nicholas C., Schouten, Robbert, Michels, Wieneke M., Bos, Willem Jan W., Szymczak, MacIej, Krajewska, Magdalena, Evans, Marie, Heimburger, Olof, Caskey, Fergus J., Wanner, Christoph, Jager, Kitty J., Dekker, Friedo W., and Meuleman, Yvette

Abstract

Background: Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex. Methods: CKD patients (≥65 years; estimated glomerular filtration rate ≤20 mL/min/1.73 m2) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off ≤70; 0-100 scale). Cox proportional hazard analysis was used to study associations between depressive symptoms and time to dialysis initiation, all-cause mortality and these outcomes combined. A joint model was used to study the association between depressive symptoms and kidney function over time. Analyses were adjusted for potential baseline confounders. Results: Overall kidney function decline in 1326 patients was -0.12 mL/min/1.73 m2/month. A total of 515 patients showed depressive symptoms. No significant association was found between depressive symptoms and kidney function over time (P = 0.08). Unlike women, men with depressive symptoms had an increased mortality rate compared with those without symptoms [adjusted hazard ratio 1.41 (95% confidence interval 1.03-1.93)]. Depressive symptoms were not significantly associated with a higher hazard of dialysis initiation, or with the combined outcome (i.e. dialysis initiation and all-cause mortality). Conclusions: There was no significant association between depressive symptoms at baseline and decline in kidney function over time in older patients with advanced CKD. Depressive symptoms at baseline were associated with a higher mortality rate in men.

Published
2022

43. Psychosocial barriers and facilitators for adherence to a healthy lifestyle among patients with chronic kidney disease: a focus group study

Author

Cardol, Cinderella K. (author), Boslooper-Meulenbelt, Karin (author), van Middendorp, Henriët (author), Meuleman, Yvette (author), Evers, A.W.M. (author), van Dijk, Sandra (author), Cardol, Cinderella K. (author), Boslooper-Meulenbelt, Karin (author), van Middendorp, Henriët (author), Meuleman, Yvette (author), Evers, A.W.M. (author), and van Dijk, Sandra (author)

Abstract

Background: Progression of chronic kidney disease (CKD) may be delayed if patients engage in healthy lifestyle behaviors. However, lifestyle adherence is very difficult and may be influenced by problems in psychosocial functioning. This qualitative study was performed to gain insights into psychosocial barriers and facilitators for lifestyle adherence among patients with CKD not receiving dialysis. Methods: Eight semi-structured focus groups were conducted with a purposive sample of 24 patients and 23 health care professionals from four Dutch medical centers. Transcripts were analyzed using thematic analysis. Subsequently, the codes from the inductive analysis were deductively mapped onto the Theoretical Domains Framework (TDF). Results: Many psychosocial barriers and facilitators for engagement in a healthy lifestyle were brought forward, such as patients’ knowledge and intrinsic motivation, emotional wellbeing and psychological distress, optimism, and disease acceptance. The findings of the inductive analysis matched all fourteen domains of the TDF. The most prominent domains were ‘social influences’’and ‘environmental context and resources’, reflecting how patients’ environments hinder or support engagement in a healthy lifestyle. Conclusions: The results indicate a need for tailored behavioral lifestyle interventions to support disease self-management. The TDF domains can guide development of adequate strategies to identify and target individually experienced psychosocial barriers and facilitators., Applied Ergonomics and Design

Published
2022
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44. FC093: Symptom Burden and Individual Symptoms Before and After Dialysis Initiation in Older Patients

Author

De Rooij, Esther, primary, Meuleman, Yvette, additional, De Fijter, Johan W, additional, Jager, Kitty J, additional, Chesnaye, Nicholas, additional, Evans, Marie, additional, Pagels, Agneta, additional, Caskey, Fergus, additional, Torino, Claudia, additional, Porto, Gaetana, additional, Szymczak, Maciej, additional, Drechsler, Christiane, additional, Wanner, Christoph, additional, Dekker, Friedo W, additional, and Hoogeveen, Ellen, additional

Published
2022
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46. Reply to ‘Depression and clinical outcomes in CKD: do anti-depressants play a role? (EQUAL Study)’

Author

Eveleens Maarse, Boukje C, primary, Chesnaye, Nicholas C, additional, Schouten, Robbert, additional, Michels, Wieneke M, additional, Bos, Willem Jan W, additional, Szymczak, Maciej, additional, Krajewska, Magdalena, additional, Evans, Marie, additional, Heimburger, Olof, additional, Caskey, Fergus J, additional, Wanner, Christoph, additional, Jager, Kitty J, additional, Dekker, Friedo W, additional, and Meuleman, Yvette, additional

Published
2022
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48. Additional file 2 of Converting from face-to-face to postal follow-up and its effects on participant retention, response rates and errors: lessons from the EQUAL study in the UK

Author

Gates, Emer, Hole, Barnaby, Hayward, Samantha, Chesnaye, Nicholas C., Meuleman, Yvette, Dekker, Friedo W., Evans, Marie, Heimburger, Olof, Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Jager, Kitty J., Roderick, Paul, and Caskey, Fergus

Abstract

Additional file 2: Infographic showing the content (black) and error rate (red) throughout the EFU patient questionnaire.

Published
2022
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