37 results on '"Methot, Joey L."'
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2. High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry.
3. Supplementary Methods, Figures 1 - 3, Tables 1 - 3 from Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities
4. Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
5. Discovery of a new series of PI3K-δ inhibitors from Virtual Screening
6. Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580]
7. Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors
8. Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators
9. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds
10. Identification of Potent Reverse Indazole Inhibitors for HPK1
11. Lacey_supplemental_tables – Supplemental material for Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors
12. Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
13. Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
14. Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow
15. Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors
16. Abstract 2254: Solid tumor activity with a selective PI3Kdelta inhibitor as a single agent and in combination with anti-PD-1
17. Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability
18. Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys
19. Potent benzoazepinone γ-secretase modulators with improved bioavailability
20. Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/d1md00097g
21. High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry
22. Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers
23. Triazoloamides as potent γ-secretase modulators with reduced hERG liability
24. Triazoles as γ-secretase modulators
25. Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor
26. Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities
27. Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization
28. SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
29. An unexpected aminocyclopropane reductive rearrangement
30. Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
31. Abstract 5433: Prolonged histone hyperacetylation with a novel class of HDAC1/2 selective inhibitors
32. The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors
33. ChemInform Abstract: An Unexpected Aminocyclopropane Reductive Rearrangement.
34. Nucleophilic Phosphine Organocatalysis
35. Synthetic Studies toward FR182877. Remarkable Solvent Effect in the Vinylogous Morita−Baylis−Hillman Cyclization
36. Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
37. Synthetic studies toward FR182877. Remarkable solvent effect in the vinylogous morita-baylis-hillman cyclization.
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