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The ICH E9(R1) addendum provides guidelines on accounting for intercurrent events in clinical trials using the estimands framework. However, there has been limited attention on the estimands framework for meta-analysis. Using treatment switching, a well-known intercurrent event that occurs frequently in oncology, we conducted a simulation study to explore the bias introduced by pooling together estimates targeting different estimands in a meta-analysis of randomized clinical trials (RCTs) that allowed for treatment switching. We simulated overall survival data of a collection of RCTs that allowed patients in the control group to switch to the intervention treatment after disease progression under fixed-effects and random-effects models. For each RCT, we calculated effect estimates for a treatment policy estimand that ignored treatment switching, and a hypothetical estimand that accounted for treatment switching by censoring switchers at the time of switching. Then, we performed random-effects and fixed-effects meta-analyses to pool together RCT effect estimates while varying the proportions of treatment policy and hypothetical effect estimates. We compared the results of meta-analyses that pooled different types of effect estimates with those that pooled only treatment policy or hypothetical estimates. We found that pooling estimates targeting different estimands results in pooled estimators that reflect neither the treatment policy estimand nor the hypothetical estimand. This finding shows that pooling estimates of varying target estimands can generate misleading results, even under a random-effects model. Adopting the estimands framework for meta-analysis may improve alignment between meta-analytic results and the clinical research question of interest.

A next-generation medium-energy (100 keV to 100 MeV) gamma-ray observatory will greatly enhance the identification and characterization of multimessenger sources in the coming decade. Coupling gamma-ray spectroscopy, imaging, and polarization to neutrino and gravitational wave detections will develop our understanding of various astrophysical phenomena including compact object mergers, supernovae remnants, active galactic nuclei and gamma-ray bursts. An observatory operating in the MeV energy regime requires technologies that are capable of measuring Compton scattered photons and photons interacting via pair production. AstroPix is a monolithic high voltage CMOS active pixel sensor which enables future gamma-ray telescopes in this energy range. AstroPix's design is iterating towards low-power (~1.5 mW/cm$^{2}$), high spatial (500 microns pixel pitch) and spectral (<5 keV at 122 keV) tracking of photon and charged particle interactions. Stacking planar arrays of AstroPix sensors in three dimensions creates an instrument capable of reconstructing the trajectories and energies of incident gamma rays over large fields of view. A prototype multi-layered AstroPix instrument, called the AstroPix Sounding rocket Technology dEmonstration Payload (A-STEP), will test three layers of AstroPix quad chips in a suborbital rocket flight. These quad chips (2x2 joined AstroPix sensors) form the 4x4 cm$^{2}$ building block of future large area AstroPix instruments, such as ComPair-2 and AMEGO-X. This payload will be the first demonstration of AstroPix detectors operated in a space environment and will demonstrate the technology's readiness for future astrophysical and nuclear physics applications. In this work, we overview the design and state of development of the ASTEP payload., Comment: 11 pages, 10 figures, SPIE Astronomical Telescopes and Instrumentation 2004 conference proceedings

We exploit the VST ATLAS quasar/QSO catalogue to perform three measurements of the quasar halo mass profile. First, we make a new estimate of the angular auto-correlation function of $\approx230,000$ ATLAS quasars with $z_{photo}\lesssim 2.5$ and $17

We cross-correlate a low-contamination subset of the VST ATLAS g < 22.5 quasar catalogue with g < 21.5 galaxy clusters, r < 21 galaxies and r < 19.5 Luminous Red Galaxies (LRGs) to probe their halo mass profiles via quasar magnification bias caused by weak lensing. In the case of galaxy clusters we find that at small scales their mass profiles are well fitted by Navarro, Frenk and White (NFW) models with masses within the expected range. For the galaxies, we find consistency with previous SDSS-based results for the galaxy-quasar cross-correlation and the galaxy auto-correlation functions. Disagreement as to whether the cross-correlation results are in tension with $\Lambda$CDM appears due to different assumptions as to whether galaxies trace mass. We conclude that halo occupation distribution (HOD) models fit the galaxy - quasar lensing results better than models where galaxies trace the mass. We further test the cluster and galaxy HOD models in the 2-halo range using the Planck Cosmic Microwave Background (CMB) lensing map, finding that the cross-correlation with both the poorest clusters and the galaxies may be marginally over-predicted by the above HOD models. Finally, we measure the magnification bias of LRGs using both quasar and CMB lensing and find that the observed quasar lensing amplitude may be $\approx 2\times$ too high and, on larger scales, the CMB lensing amplitude may be too low to be explained by a standard LRG HOD model., Comment: 13 pages, 11 figures, accepted for publication in MNRAS

The stellar Rossby number (Ro) is a dimensionless quantity that is used in the description of fluid flows. It characterizes the relative importance of Coriolis forces on convective motions, which is central to understanding magnetic stellar evolution. Here we present an expanded sample of Kepler asteroseismic targets to help calibrate the relation between Ro and Gaia color, and we extend the relation to redder colors using observations of the mean activity levels and rotation periods for a sample of brighter stars from the Mount Wilson survey. Our quadratic fit to the combined sample is nearly linear between 0.55 < G_BP-G_RP < 1.2, and can be used to estimate Ro for stars with spectral types between F5 and K3. The strong deviation from linearity in the original calibration may reflect an observational bias against the detection of solar-like oscillations at higher activity levels for the coolest stars., Comment: 3 pages, 1 figure, AAS Journals accepted

The solar-type subgiant $\beta$ Hyi has long been studied as an old analog of the Sun. Although the rotation period has never been measured directly, it was estimated to be near 27 days. As a southern hemisphere target it was not monitored by long-term stellar activity surveys, but archival International Ultraviolet Explorer data revealed a 12 year activity cycle. Previous ground-based asteroseismology suggested that the star is slightly more massive and substantially larger and older than the Sun, so the similarity of both the rotation rate and the activity cycle period to solar values is perplexing. We use two months of precise time-series photometry from the Transiting Exoplanet Survey Satellite (TESS) to detect solar-like oscillations in $\beta$ Hyi and determine the fundamental stellar properties from asteroseismic modeling. We also obtain a direct measurement of the rotation period, which was previously estimated from an ultraviolet activity-rotation relation. We then use rotational evolution modeling to predict the rotation period expected from either standard spin-down or weakened magnetic braking (WMB). We conclude that the rotation period of $\beta$ Hyi is consistent with WMB, and that changes in stellar structure on the subgiant branch can reinvigorate the large-scale dynamo and briefly sustain magnetic activity cycles. Our results support the existence of a "born-again" dynamo in evolved subgiants -- previously suggested to explain the cycle in 94 Aqr Aa -- which can best be understood within the WMB scenario., Comment: ApJ accepted. 8 pages including 6 figures and 2 tables

Asteroseismology of dwarf stars cooler than the Sun is very challenging due to the low amplitudes and rapid timescales of oscillations. Here, we present the asteroseismic detection of solar-like oscillations at 4-minute timescales ($\nu_{\mathrm{max}}\sim4300\mu$Hz) in the nearby K-dwarf $\sigma$ Draconis using extreme precision Doppler velocity observations from the Keck Planet Finder and 20-second cadence photometry from NASA's Transiting Exoplanet Survey Satellite. The star is the coolest dwarf star to date with both velocity and luminosity observations of solar-like oscillations, having amplitudes of $5.9\pm0.8\,$cm$\,\text{s}^{-1}$ and $0.8\pm0.2$ ppm, respectively. These measured values are in excellent agreement with established luminosity-velocity amplitude relations for oscillations and provide further evidence that mode amplitudes for stars with $T_{\mathrm{eff}}<\,5500\,$K diminish in scale following a $(L/M)^{1.5}$ relation. By modeling the star's oscillation frequencies from photometric data, we measure an asteroseismic age of $4.5\pm0.9\,\rm{(ran)} \pm 1.2\,\rm{(sys)}$ Gyr. The observations demonstrate the capability of next-generation spectrographs and precise space-based photometry to extend observational asteroseismology to nearby cool dwarfs, which are benchmarks for stellar astrophysics and prime targets for directly imaging planets using future space-based telescopes., Comment: Accepted for publication in The Astrophysical Journal

The precise reconstruction of Compton-scatter events is paramount for an imaging medium-energy gamma-ray telescope. The proposed AMEGO-X is enabled by a silicon tracker utilizing AstroPix chips - a pixelated silicon HVCMOS sensor novel for space use. To achieve science goals, each 500 x 500 $\mu$m$^2$ pixel must be sensitive for energy deposits ranging from 25 - 700 keV with an energy resolution of 5 keV at 122 keV (< 10%). This is achieved through depletion of the 500 $\mu$m thick sensor, although complete depletion poses an engineering and design challenge. This work will summarize the current status of depletion measurements highlighting direct measurement with TCT laser scanning and the agreement with simulation. Future plans for further testing will also be identified., Comment: 13 pages, proceedings, SPIE Astronomical Telescopes + Instrumentation 2024, June 16-21 2024

Future tracking systems in High Energy Physics experiments will require large instrumented areas with low radiation length. Crystalline silicon sensors have been used in tracking systems for decades, but are difficult to manufacture and costly to produce for large areas. We are exploring alternative sensor materials that are amenable to fast fabrication techniques used for thin film devices. Indium Phosphide pad sensors were fabricated at Argonne National Lab using commercially available InP:Fe 2-inch mono-crystal substrates. Current-voltage and capacitance-voltage characterizations were performed to study the basic operating characteristics of a group of sensors. Micro-focused X-ray beams at Canadian Light Source and Diamond Light Source were used to study the response to ionizing radiation, and characterize the uniformity of the response for several devices. The results show a high degree of performance uniformity in our evaluations, both within a device and between the 48 tested devices. This motivates further studies into thin film devices for future tracking detectors., Comment: 30 pages, 27 figures

Stellar spin down is a critical yet poorly understood component of stellar evolution. In particular, results from the Kepler Mission imply that mature age, solar-type stars have inefficient magnetic braking, resulting in a stalled spin down rate. However, a large number of precise asteroseismic ages are needed for mature ($\geq$ 3Gyr) stars in order to probe the regime where traditional and stalled spin-down models differ. In this paper, we present a new asteroseismic benchmark star for gyrochronology discovered using reprocessed Kepler short cadence data. KIC 11029516 (Papayu) is a bright ($K_{p}$ = 9.6 mag) solar-type star with well-measured rotation period (21.1$\pm$0.8 days) from spot modulation using 4 years of Kepler long cadence data. We combine asteroseismology and spectroscopy to obtain $T_{eff}=5888\pm100$ K, $\rm{[Fe/H]} = 0.30 \pm 0.06\,$ dex, $M = 1.24 \pm 0.05 M_{\odot}$, $R = 1.34 \pm 0.02 R_{\odot}$ and age of 4.0 $\pm$ 0.4 Gyr, making Papayu one of the most similar stars to the Sun in terms of temperature and radius with an asteroseismic age and a rotation period measured from spot modulation. We find that Papayu sits at the transition of where traditional and weakened spin-down models diverge. A comparison with stars of similar zero-age main-sequence temperatures supports previous findings that weakened spin-down models are required to explain the ages and rotation periods of old solar-type stars.

We report on the discovery and validation of a transiting long-period mini-Neptune orbiting a bright (V = 9.0 mag) G dwarf (TOI 4633; R = 1.05 RSun, M = 1.10 MSun). The planet was identified in data from the Transiting Exoplanet Survey Satellite by citizen scientists taking part in the Planet Hunters TESS project. Modeling of the transit events yields an orbital period of 271.9445 +/- 0.0040 days and radius of 3.2 +/- 0.20 REarth. The Earth-like orbital period and an incident flux of 1.56 +/- 0.2 places it in the optimistic habitable zone around the star. Doppler spectroscopy of the system allowed us to place an upper mass limit on the transiting planet and revealed a non-transiting planet candidate in the system with a period of 34.15 +/- 0.15 days. Furthermore, the combination of archival data dating back to 1905 with new high angular resolution imaging revealed a stellar companion orbiting the primary star with an orbital period of around 230 years and an eccentricity of about 0.9. The long period of the transiting planet, combined with the high eccentricity and close approach of the companion star makes this a valuable system for testing the formation and stability of planets in binary systems., Comment: 24 pages, 16 figures, 4 tables

Thin film detectors which incorporate semiconductor materials other than silicon have the potential to build upon their unique material properties and offer advantages such as faster response times, operation at room temperature, and radiation hardness. To explore the possibility, promising candidate materials were selected, and particle tracking detectors were fabricated. An indium phosphide detector with a metal-insulator-metal (MIM) structure has been fabricated for particle tracking. The detector was tested using radioactive sources and a high energy proton beam at Fermi National Accelerator Laboratory. In addition to its simplistic design and fabrication process, the indium phosphide particle detector showed a very fast response time of hundreds of picoseconds for the 120 GeV protons, which are comparable to the ultra-fast silicon detectors. This fast-timing response is attributed to the high electron mobility of indium phosphide. Such material properties can be leveraged to build novel detectors with superlative performance., Comment: 10 pages, 7 figures

Fuelled by space photometry, asteroseismology is vastly benefitting the study of cool main-sequence stars, which exhibit convection-driven solar-like oscillations. Even so, the tiny oscillation amplitudes in K dwarfs continue to pose a challenge to space-based asteroseismology. A viable alternative is offered by the lower stellar noise over the oscillation timescales in Doppler observations. In this letter we present the definite detection of solar-like oscillations in the bright K5 dwarf $\epsilon$ Indi based on time-intensive observations collected with the ESPRESSO spectrograph at the VLT, thus making it the coolest seismic dwarf ever observed. We measured the frequencies of a total of 19 modes of degree $\ell=0$--2 along with $\nu_{\rm max}=5305\pm176\:{\rm \mu Hz}$ and $\Delta\nu=201.25\pm0.16\:{\rm \mu Hz}$. The peak amplitude of radial modes is $2.6\pm0.5\:{\rm cm\,s^{-1}}$, or a mere ${\sim} 14\%$ of the solar value. Measured mode amplitudes are ${\sim} 2$ times lower than predicted from a nominal $L/M$ scaling relation and favour a scaling closer to $(L/M)^{1.5}$ below ${\sim} 5500\:{\rm K}$, carrying important implications for our understanding of the coupling efficiency between pulsations and near-surface convection in K dwarfs. This detection conclusively shows that precise asteroseismology of cool dwarfs is possible down to at least the mid-K regime using next-generation spectrographs on large-aperture telescopes, effectively opening up a new domain in observational asteroseismology., Comment: Accepted for publication in Astronomy & Astrophysics Letters

This paper provides answers to several open problems about equational theories of idempotent semifields. In particular, it is proved that (i) no equational theory of a non-trivial class of idempotent semifields has a finite basis; (ii) there are continuum-many equational theories of classes of idempotent semifields; and (iii) the equational theory of the class of idempotent semifields is co-NP-complete.

The consistently low activity level of the old solar analog 51 Peg not only facilitated the discovery of the first hot Jupiter, but also led to the suggestion that the star could be experiencing a magnetic grand minimum. However, the 50 year time series showing minimal chromospheric variability could also be associated with the onset of weakened magnetic braking (WMB), where sufficiently slow rotation disrupts cycling activity and the production of large-scale magnetic fields by the stellar dynamo, thereby shrinking the Alfven radius and inhibiting the efficient loss of angular momentum to magnetized stellar winds. In this Letter, we evaluate the magnetic evolutionary state of 51 Peg by estimating its wind braking torque. We use new spectropolarimetric measurements from the Large Binocular Telescope to reconstruct the large-scale magnetic morphology, we reanalyze archival X-ray measurements to estimate the mass-loss rate, and we detect solar-like oscillations in photometry from the Transiting Exoplanet Survey Satellite, yielding precise stellar properties from asteroseismology. Our estimate of the wind braking torque for 51 Peg clearly places it in the WMB regime, driven by changes in the mass-loss rate and the magnetic field strength and morphology that substantially exceed theoretical expectations. Although our revised stellar properties have minimal consequences for the characterization of the exoplanet, they have interesting implications for the current space weather environment of the system., Comment: ApJ Letters (accepted), 6 pages including 4 figures and 1 table. Data available at https://doi.org/10.5281/zenodo.8381444

Benchmarking drug efficacy is a critical step in clinical trial design and planning. The challenge is that much of the data on efficacy endpoints is stored in scientific papers in free text form, so extraction of such data is currently a largely manual task. Our objective is to automate this task as much as possible. In this study we have developed and optimised a framework to extract efficacy endpoints from text in scientific papers, using a machine learning approach. Our machine learning model predicts 25 classes associated with efficacy endpoints and leads to high F1 scores (harmonic mean of precision and recall) of 96.4% on the test set, and 93.9% and 93.7% on two case studies. These methods were evaluated against - and showed strong agreement with - subject matter experts and show significant promise in the future of automating the extraction of clinical endpoints from free text. Clinical information extraction from text data is currently a laborious manual task which scales poorly and is prone to human error. Demonstrating the ability to extract efficacy endpoints automatically shows great promise for accelerating clinical trial design moving forwards.

The one-variable fragment of a first-order logic may be viewed as an "S5-like" modal logic, where the universal and existential quantifiers are replaced by box and diamond modalities, respectively. Axiomatizations of these modal logics have been obtained for special cases -- notably, the modal counterparts S5 and MIPC of the one-variable fragments of first-order classical logic and intuitionistic logic -- but a general approach, extending beyond first-order intermediate logics, has been lacking. To this end, a sufficient criterion is given in this paper for the one-variable fragment of a semantically-defined first-order logic -- spanning families of intermediate, substructural, many-valued, and modal logics -- to admit a natural axiomatization. More precisely, such an axiomatization is obtained for the one-variable fragment of any first-order logic based on a variety of algebraic structures with a lattice reduct that has the superamalgamation property, building on a generalized version of a functional representation theorem for monadic Heyting algebras due to Bezhanishvili and Harding. An alternative proof-theoretic strategy for obtaining such axiomatization results is also developed for first-order substructural logics that have a cut-free sequent calculus and admit a certain interpolation property., Comment: arXiv admin note: text overlap with arXiv:2209.08566

It was proved by Maksimova in 1977 that exactly eight varieties of Heyting algebras have the amalgamation property, and hence exactly eight axiomatic extensions of intuitionistic propositional logic have the deductive interpolation property. The prevalence of the deductive interpolation property for axiomatic extensions of substructural logics and the amalgamation property for varieties of pointed residuated lattices, their equivalent algebraic semantics, is far less well understood, however. Taking as our starting point a formulation of intuitionistic propositional logic as the full Lambek calculus with exchange, weakening, and contraction, we investigate the role of the exchange rule--algebraically, the commutativity law--in determining the scope of these properties. First, we show that there are continuum-many varieties of idempotent semilinear residuated lattices that have the amalgamation property and contain non-commutative members, and hence continuum-many axiomatic extensions of the corresponding logic that have the deductive interpolation property in which exchange is not derivable. We then show that, in contrast, exactly sixty varieties of commutative idempotent semilinear residuated lattices have the amalgamation property, and hence exactly sixty axiomatic extensions of the corresponding logic with exchange have the deductive interpolation property. From this latter result, it follows also that there are exactly sixty varieties of commutative idempotent semilinear residuated lattices whose first-order theories have a model completion.

Magnetic activity is a ubiquitous feature of stars with convective outer layers, with implications from stellar evolution to planetary atmospheres. Investigating the mechanisms responsible for the observed stellar activity signals from days to billions of years is important in deepening our understanding of the spatial configurations and temporal patterns of stellar dynamos, including that of the Sun. In this paper, we focus on three problems and their possible solutions. We start with direct field measurements and show how they probe the dependence of magnetic flux and its density on stellar properties and activity indicators. Next, we review the current state-of-the-art in physics-based models of photospheric activity patterns and their variation from rotational to activity-cycle timescales. We then outline the current state of understanding in the long-term evolution of stellar dynamos, first by using chromospheric and coronal activity diagnostics, then with model-based implications on magnetic braking, which is the key mechanism by which stars spin down and become inactive as they age. We conclude by discussing possible directions to improve the modeling and analysis of stellar magnetic fields., Comment: Accepted for publication in Space Science Reviews

The magnetic field of the Sun is generated by internal dynamo process with a cyclic period of 11 years or a 22 year magnetic cycle. The signatures of the Sun's magnetic cycle are observed in the different layers of its atmosphere and in its internal layers. In this review, we use the same diagnostics to understand the magnetic cycles of other stars with the same internal structure as the Sun. We review what is currently known about mapping the surface magnetic fields, chromospheric and coronal indicators, cycles in photometry and asteroseismology. We conclude our review with an outlook for the future., Comment: accepted by Space Science Reviews

Despite a growing sample of precisely measured stellar rotation periods and ages, the strength of magnetic braking and the degree of departure from standard (Skumanich-like) spindown have remained persistent questions, particularly for stars more evolved than the Sun. Rotation periods can be measured for stars older than the Sun by leveraging asteroseismology, enabling models to be tested against a larger sample of old field stars. Because asteroseismic measurements of rotation do not depend on starspot modulation, they avoid potential biases introduced by the need for a stellar dynamo to drive starspot production. Using a neural network trained on a grid of stellar evolution models and a hierarchical model-fitting approach, we constrain the onset of weakened magnetic braking. We find that a sample of stars with asteroseismically-measured rotation periods and ages is consistent with models that depart from standard spindown prior to reaching the evolutionary stage of the Sun. We test our approach using neural networks trained on model grids produced by separate stellar evolution codes with differing physical assumptions and find that the choices of grid physics can influence the inferred properties of the braking law. We identify the normalized critical Rossby number ${\rm Ro}_{\rm crit}/{\rm Ro}_\odot = 0.91\pm0.03$ as the threshold for the departure from standard rotational evolution. This suggests that weakened magnetic braking poses challenges to gyrochronology for roughly half of the main sequence lifetime of sun-like stars., Comment: 26 pages, 10 figures