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1,847 results on '"Metastasis -- Genetic aspects"'

1. Research from Aerospace Research Institute Yields New Study Findings on Breast Cancer (E-cadherin Gene Expression Changes in MCF-7 Breast Cancer Cell Line Under Simulated Microgravity Condition)

Subjects
Oncology, Experimental -- Reports -- Genetic aspects, Gene expression -- Reports -- Genetic aspects, Genetic research -- Reports -- Genetic aspects, Metastasis -- Genetic aspects, Cancer -- Genetic aspects -- Research, Breast cancer -- Genetic aspects, Physical fitness -- Reports
Abstract

2024 NOV 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on breast cancer. According to news reporting out [...]

Published
2024

2. Regulation of tmTNF-a Processing by FRMD8 in Triple-Negative Breast Cancer Metastasis: Insights into Molecular Pathway Dynamics

Subjects
Molecular dynamics, Genetic research -- Genetic aspects, Metastasis -- Genetic aspects, Mortality -- Genetic aspects, Cancer -- Genetic aspects, Tumor necrosis factor -- Genetic aspects, Breast cancer -- Genetic aspects, Physical fitness, Health
Abstract

2024 OCT 19 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2024

3. Research from Cincinnati Children's Hospital Medical Center Provide New Insights into Breast Cancer (Lipid profiling of RON and DEK-dependent signaling in breast cancer guides discovery of gene networks predictive of poor outcomes)

Subjects
Children's Hospital Medical Center, Physiological aspects, Genetic aspects, Cancer genetics -- Genetic aspects, Medical centers -- Physiological aspects, Cancer research -- Genetic aspects -- Physiological aspects, Breast cancer -- Genetic aspects, Cancer metastasis -- Genetic aspects, Oncology, Experimental -- Genetic aspects -- Physiological aspects, Metastasis -- Genetic aspects, Cancer -- Genetic aspects -- Research
Abstract

2024 OCT 3 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on breast cancer. According to news originating from Cincinnati, Ohio, [...]

Published
2024

4. Repare: Endometrial cancers with CCNE1 amplifications carry poor prognosis

Subjects
Cancer patients, Metastasis -- Genetic aspects, Endometrial cancer -- Genetic aspects, Chemotherapy, Cancer -- Chemotherapy, Ovarian cancer -- Genetic aspects, Business, News, opinion and commentary
Abstract

Repare Therapeutics presented new data on Friday highlighting the impact of alterations in FBXW7, PPP2R1A and CCNE1 in patients with metastatic ovarian and endometrial cancers based on an analysis in [...]

Published
2024

5. Cooper Medical School of Rowan University Researchers Update Current Data on Breast Cancer (Emerin deficiency drives MCF7 cells to an invasive phenotype)

Subjects
Oncology, Experimental -- Genetic aspects, Women -- Health aspects, Biochemistry -- Genetic aspects, Metastasis -- Genetic aspects, Cancer -- Research, Breast cancer -- Genetic aspects, Health, Women's issues/gender studies
Abstract

2024 SEP 19 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on breast cancer. According to news reporting from Cooper Medical [...]

Published
2024

6. Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism

Subjects
Genomics -- Genetic aspects, Metastasis -- Genetic aspects, Stem cells -- Genetic aspects, Genomes -- Genetic aspects, Cancer -- Genetic aspects, Breast cancer -- Genetic aspects, Physical fitness, Health
Abstract

2024 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2024

7. European Institute of Oncology Researchers Update Understanding of Metastatic Breast Cancer (PIK3CA mutation analysis in circulating tumor cells of patients with hormone receptor positive metastatic breast cancer)

Subjects
Oncology, Experimental -- Genetic aspects, Biochemistry -- Genetic aspects, Metastasis -- Genetic aspects, Hormones -- Genetic aspects, Cancer -- Research, Breast cancer -- Genetic aspects, Physical fitness, Health
Abstract

2024 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on metastatic breast cancer are discussed in a new report. [...]

Published
2024

8. Data from University of Illinois Advance Knowledge in Cancer (Mancr Lncrna Modulates Cell-cycle Progression and Metastasis By Cis-regulation of Nuclear rho-gef)

Subjects
United States. National Institutes of Health, Metastasis -- Genetic aspects, Physical fitness, Health, University of Illinois at Urbana-Champaign
Abstract

2024 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Cancer are presented in a new report. According to [...]

Published
2024

9. New Clinical Oncology Study Findings Recently Were Reported by Researchers at Lawrence Berkeley National Laboratory (A Susceptibility Gene Signature for Erbb2-driven Mammary Tumour Development and Metastasis In Collaborative Cross Mice)

Subjects
United States. Department of Defense, United States. Lawrence Berkeley National Laboratory, Genetic research -- Genetic aspects, Metastasis -- Genetic aspects, Local government, Breast cancer -- Genetic aspects, Disease susceptibility -- Genetic aspects, Physical fitness, Health, European Union
Abstract

2024 SEP 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Clinical Oncology. According to news originating from [...]

Published
2024

11. Data from Islamic Azad University Broaden Understanding of Gastric Cancer (Evaluation of DPT Metastasis Suppressor Gene Expression in Human Gastric Cancer)

Subjects
Oncology, Experimental -- Reports -- Genetic aspects, Gene expression -- Reports -- Genetic aspects, Genes -- Reports -- Genetic aspects, Metastasis -- Genetic aspects, Stomach cancer -- Genetic aspects, Cancer -- Genetic aspects -- Research, Physical fitness -- Reports, Health
Abstract

2024 AUG 31 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on gastric cancer is the subject of a new report. [...]

Published
2024

14. Findings from Dana-Farber Cancer Institute Provides New Data about Brain Metastasis (Loss of kmt2c or kmt2d Drives Brain Metastasis Via Kdm6a-dependent Upregulation of Mmp3)

Subjects
United States. National Cancer Institute, Brain research -- Genetic aspects, Medical research, Medicine, Experimental, Lysine -- Genetic aspects, Metastasis -- Genetic aspects, Cancer -- Genetic aspects, Methyltransferases, Physical fitness, Health
Abstract

2024 JUL 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Brain Diseases and Conditions - Brain Metastasis are discussed [...]

Published
2024

15. Cancer Institute Hospital Researcher Provides New Insights into Colon Cancer (Clinicopathological characteristics and survival in metastatic colorectal cancer with short-form APC mutations)

Subjects
Oncology, Experimental -- Reports -- Genetic aspects, Metastasis -- Genetic aspects, Colorectal cancer -- Genetic aspects, Cancer -- Research, Physical fitness -- Reports, Health
Abstract

2024 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on colon cancer have been published. According to news [...]

Published
2024

16. Data on Breast Cancer Described by Researchers at Baylor College of Medicine [TWIST1 Drives Cytotoxic CD8+ T-Cell Exhaustion through Transcriptional Activation of * * CD274* * (PD-L1) Expression in Breast Cancer Cells]

Subjects
Oncology, Experimental -- Genetic aspects, Women -- Health aspects, Biochemistry -- Genetic aspects, T cells -- Genetic aspects, Metastasis -- Genetic aspects, Genetic transcription -- Genetic aspects, Cancer -- Research, Breast cancer -- Genetic aspects, Cells -- Genetic aspects, Health, Women's issues/gender studies, Baylor College of Medicine
Abstract

2024 JUL 4 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on breast cancer are presented in a new report. According to news [...]

Published
2024

17. Data on Breast Cancer Discussed by Researchers at Baylor College of Medicine (An essential gene signature of breast cancer metastasis reveals targetable pathways)

Subjects
Oncology, Experimental -- Genetic aspects, Women -- Health aspects, Gene expression -- Genetic aspects, Genetic research -- Genetic aspects, Genes -- Genetic aspects, Metastasis -- Genetic aspects, Cancer -- Genetic aspects -- Research, Breast cancer -- Genetic aspects, Cells -- Genetic aspects, Health, Women's issues/gender studies, Baylor College of Medicine
Abstract

2024 JUL 4 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Data detailed on breast cancer have been presented. According to news reporting out of [...]

Published
2024

20. New Cancer Gene Therapy Study Findings Recently Were Reported by Researchers at Weifang People's Hospital (Mixtures of Doxorubicin-loaded Micelles and Berberine and Mifepristone Co-loaded Liposomes Inhibit Breast Cancer Metastasis Based On ...)

Subjects
Oncology, Experimental -- Health aspects -- Reports -- Genetic aspects, Women -- Health aspects, Genetic research -- Reports -- Genetic aspects -- Health aspects, Metastasis -- Genetic aspects, Mifepristone -- Reports -- Health aspects, Gene therapy -- Reports -- Health aspects, Cancer -- Care and treatment -- Genetic aspects -- Research, Breast cancer -- Genetic aspects, Health, Women's issues/gender studies
Abstract

2024 JUN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on Biotechnology - Cancer Gene Therapy. According to news reporting [...]

Published
2024

21. The transcriptional landscape of metastatic hormone-naive prostate cancer

Subjects
Prostate cancer -- Genetic aspects, Metastasis -- Genetic aspects, Hormones -- Genetic aspects, Genetic transcription -- Genetic aspects, Physical fitness, Health
Abstract

2024 JUN 8 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2024

22. Patent Application Titled 'Combination Gene Therapy For Treatment Of Metastatic Cancer' Published Online (USPTO 20240148902)

Subjects
Women -- Health aspects, Metastasis -- Genetic aspects, Gene therapy, Cancer -- Care and treatment -- Genetic aspects, Health, Women's issues/gender studies
Abstract

2024 MAY 30 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- According to news reporting originating from Washington, D.C., by NewsRx journalists, a patent application [...]

Published
2024

24. Boundless Bio: First Patient Dosed in First-in-Human Phase 1/2 Clinical Trial of BBI-825 in Cancer Patients with Resistance Gene Amplifications

Subjects
Genes -- Genetic aspects, Metastasis -- Genetic aspects, Cancer -- Genetic aspects, Clinical trials, Extrachromosomal DNA -- Genetic aspects, Arts and entertainment industries
Abstract

Boundless Bio, a clinical-stage oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to patients with previously intractable oncogene amplified cancers, reported that the first patient has been [...]

Published
2024

26. HOW HYPOXIA HELPS CANCER SPREAD

Subjects
Metastasis -- Genetic aspects, Cancer -- Genetic aspects, News, opinion and commentary
Abstract

BALTIMORE, MD -- The following information was released by Johns Hopkins Medicine: Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to [...]

Published
2024

27. A Rare Case of Metastatic Spiradenocarcinoma With CDKN2A Mutation

Subjects
Metastasis -- Genetic aspects, Pemetrexed, Health
Abstract

Spiradenocarcinomas are rare malignant skin adnexal tumors. We describe a novel case of a patient with an aggressive CDKN2A-mutated spiradenocarcinoma who responded to a CDK4/6 inhibitor. This case highlights the unique nature of spiradenocarcinomas as well as the potential benefit of targeted therapy., A 70-year-old woman with no prior oncologic history presented with a rapidly enlarging growth on the first dorsal web of her right hand. She initially noticed it 2 years prior [...]

Published
2024

29. Data from University of Kiel Update Knowledge in Pancreatic Cancer (Epithelial and Mesenchymal-like Pancreatic Cancer Cells Exhibit Different Stem Cell Phenotypes Associated with Different Metastatic Propensities)

Subjects
Metastasis -- Genetic aspects, Stem cells -- Genetic aspects, Pancreatic cancer -- Genetic aspects, Stem cell research -- Genetic aspects, Health
Abstract

2024 FEB 26 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Current study results on pancreatic cancer have been published. According to news reporting out [...]

Published
2024

31. Data on Cancer Detailed by Researchers at Central South University (Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance)

Subjects
Oncology, Experimental -- Genetic aspects, Metastasis -- Genetic aspects, Cancer -- Genetic aspects -- Research, Physical fitness, Health
Abstract

2024 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on cancer have been published. According to news reporting [...]

Published
2024

32. Chugai obtains approval for FoundationOne CDx Cancer Genomic Profile to be used as a companion diagnostic for PARP inhibitor, Talazoparib

Subjects
Chugai Pharmaceutical Company Ltd., Gene mutations -- Genetic aspects, Prostate cancer -- Genetic aspects, Metastasis -- Genetic aspects, Cancer -- Genetic aspects, Pharmaceutical industry, Pharmaceuticals and cosmetics industries
Abstract

Chugai Pharmaceutical Co., Ltd. announced that it has obtained approval from the Ministry of Health, Labour and Welfare (MHLW) on February 2, 2024, for FoundationOne CDx Cancer Genomic Profile to [...]

Published
2024

33. A susceptibility gene signature for ERBB2-driven mammary tumor development and metastasis in Collaborative Cross mice with human translational value

Subjects
Genetic research -- Genetic aspects, Metastasis -- Genetic aspects, Breast cancer -- Genetic aspects, Disease susceptibility -- Genetic aspects, Physical fitness, Health
Abstract

2024 JAN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2024

36. Reports Outline Breast Cancer Study Findings from Institute of Cancer Research (Genomic profiling and pre-clinical modelling of breast cancer leptomeningeal metastasis reveals acquisition of a lobular-like phenotype)

Subjects
Women -- Health aspects, Metastasis -- Genetic aspects, Breast cancer -- Genetic aspects, Health, Women's issues/gender studies
Abstract

2023 DEC 7 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New study results on breast cancer have been published. According to news reporting originating [...]

Published
2023

47. Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress

Author

Yang, Zi-Yan, Yan, Xian-Chun, Zhang, Jia-Yu-Lin, Liang, Liang, Gao, Chun-Chen, Zhang, Pei-Ran, Liu, Yuan, Sun, Jia-Xing, Ruan, Bai, Duan, Juan-Li, Wang, Ruo-Nan, Feng, Xing-Xing, Che, Bo, Xiao, Tian, and Han, Hua

Subjects
Tumor proteins -- Genetic aspects, Genes -- Physiological aspects -- Genetic aspects, Metastasis -- Genetic aspects, Biosynthesis -- Genetic aspects -- Physiological aspects, Endothelium -- Physiological aspects -- Genetic aspects, Ablation (Surgery) -- Physiological aspects, B cells -- Physiological aspects -- Genetic aspects, RNA -- Physiological aspects -- Genetic aspects, Cancer -- Genetic aspects, Genetic transcription -- Genetic aspects -- Physiological aspects, Health care industry
Abstract

Human cancers induce a chaotic, dysfunctional vasculature that promotes tumor growth and blunts most current therapies; however, the mechanisms underlying the induction of a dysfunctional vasculature have been unclear. Here, we show that split end (SPEN), a transcription repressor, coordinates rRNA synthesis in endothelial cells (ECs) and is required for physiological and tumor angiogenesis. SPEN deficiency attenuated EC proliferation and blunted retinal angiogenesis, which was attributed to p53 activation. Furthermore, SPEN knockdown activated p53 by upregulating noncoding promoter RNA (pRNA), which represses rRNA transcription and triggers p53-mediated nucleolar stress. In human cancer biopsies, a low endothelial SPEN level correlated with extended overall survival. In mice, endothelial SPEN deficiency compromised rRNA expression and repressed tumor growth and metastasis by normalizing tumor vessels, and this was abrogated by p53 haploinsufficiency. rRNA gene transcription is driven by RNA polymerase I (RNPI). We found that CX-5461, an RNPI inhibitor, recapitulated the effect of Spen ablation on tumor vessel normalization and combining CX-5461 with cisplatin substantially improved the efficacy of treating tumors in mice. Together, these results demonstrate that SPEN is required for angiogenesis by repressing pRNA to enable rRNA gene transcription and ribosomal biogenesis and that RNPI represents a target for tumor vessel normalization therapy of cancer., Introduction Angiogenesis, the growth of new vessels from existing ones, is required for vascularization of both physiological and pathological tissues (1). Tumor angiogenesis, however, is driven by abnormally high level [...]

Published
2023
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48. Reports from Fudan University Add New Data to Findings in Cancer Gene Therapy (Identification of Feature Genes and Molecular Mechanisms Involved In Cell Communication In Uveal Melanoma Through Analysis of Single-cell Sequencing Data)

Subjects
Fudan University -- Reports, Genes -- Reports -- Genetic aspects -- Analysis -- Health aspects, Metastasis -- Genetic aspects, Gene therapy -- Reports -- Analysis -- Health aspects, Cancer -- Genetic aspects, Melanoma -- Genetic aspects
Abstract

2024 NOV 5 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Biotechnology - Cancer Gene Therapy are discussed in a new report. According [...]

Published
2024

50. Extracellular vesicles regulate metastable phenotypes of lymphangioleiomyomatosis cells via shuttling ATP synthesis to pseudopodia and activation of integrin adhesion complexes. (Updated September 10, 2024)

Subjects
Sarcoma -- Genetic aspects, Metastasis -- Genetic aspects, Stem cells -- Genetic aspects, Integrins -- Genetic aspects, Health
Abstract

2024 SEP 27 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- According to news reporting based on a preprint abstract, our journalists obtained the [...]

Published
2024

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