1. Inside the lungs of COVID-19 disease
- Author
-
Manuel Schibler, Johannes Alexander Lobrinus, Tony Fracasso, Christelle Lardi, and Diego Aguiar
- Subjects
Influenzavirus A ,Pathology ,Influenzavirus B ,Rhinovirus ,Neutrophils ,T-Lymphocytes ,Post-mortem ,Autopsy ,Disease ,ddc:616.07 ,Influenzavirus A/genetics/isolation & purification ,medicine.disease_cause ,01 natural sciences ,Procalcitonin ,T-Lymphocytes/pathology ,Bocavirus/genetics/isolation & purification ,0302 clinical medicine ,Coronavirus Infections/pathology ,Edema ,Morbid ,Diffuse alveolar damage ,Lung ,Interstitial pneumonia ,Coronavirus ,ddc:616 ,Influenzavirus B/genetics/isolation & purification ,Reverse Transcriptase Polymerase Chain Reaction ,Adenoviridae/genetics/isolation & purification ,Topical Collection on COVID-19 ,respiratory system ,Rhinovirus/genetics/isolation & purification ,Obesity, Morbid ,C-Reactive Protein ,medicine.anatomical_structure ,Metapneumovirus/genetics/isolation & purification ,Female ,medicine.symptom ,Coronavirus Infections ,Megakaryocytes ,Switzerland ,Adult ,medicine.medical_specialty ,Macrophages/pathology ,Procalcitonin/blood ,Lung/pathology ,Pneumonia, Viral ,Human/genetics/isolation & purification ,Viral/pathology ,Real-Time Polymerase Chain Reaction ,Adenoviridae ,Pathology and Forensic Medicine ,Bocavirus ,C-Reactive Protein/analysis ,Betacoronavirus ,03 medical and health sciences ,Betacoronavirus/genetics/isolation & purification ,medicine ,Humans ,Megakaryocytes/pathology ,Obesity ,030216 legal & forensic medicine ,Pandemics ,Neutrophils/pathology ,SARS-CoV-2 ,business.industry ,Macrophages ,ddc:614.1 ,010401 analytical chemistry ,COVID-19 ,Pneumonia ,Coronavirus/genetics/isolation & purification ,0104 chemical sciences ,respiratory tract diseases ,Respiratory Syncytial Virus, Human ,Respiratory Syncytial Virus ,Metapneumovirus ,business - Abstract
In the setting of the coronavirus disease 2019 (COVID-19) pandemic, only few data regarding lung pathology induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is available, especially without medical intervention interfering with the natural evolution of the disease. We present here the first case of forensic autopsy of a COVID-19 fatality occurring in a young woman, in the community. Diagnosis was made at necropsy and lung histology showed diffuse alveolar damage, edema, and interstitial pneumonia with a geographically heterogeneous pattern, mostly affecting the central part of the lungs. This death related to COVID-19 pathology highlights the heterogeneity and severity of central lung lesions after natural evolution of the disease.
- Published
- 2020