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1. CES1 and SLC6A2 Genetic Variants As Predictors of Response To Methylphenidate in Autism Spectrum Disorders

Author

Hernandez MH, Bote V, Serra-LLovich A, Cendros M, Salazar J, Mestres C, Guijarro S, Alvarez A, Lamborena C, Mendez I, Sanchez B, Hervas A, and Arranz MJ

Subjects
ces1, slc6a2, autistic spectrum disorders, asd, methylphenidate, attention deficit hyperactivity disorders, adhd., Therapeutics. Pharmacology, RM1-950
Abstract

Marta H Hernandez1,2 *, Valentin Bote3 *, Alexandre Serra-LLovich,1 Marc Cendros,1,4 Juliana Salazar,5 Conxita Mestres,2 Silvina Guijarro,3 Aida Alvarez,3 Cristina Lamborena,3 Iria Mendez,3 Bernardo Sanchez,3 Amaia Hervas,3 Maria J Arranz1,2 1Research Laboratory Unit, Fundació Docència i Recerca Mútua Terrassa, Terrassa, Spain; 2School of Health Sciences Blanquerna, University Ramon Llull, Barcelona, Spain; 3Department of Child and Adolescent Psychiatry, Hospital Universitari Mútua Terrassa, Terrassa, Spain; 4EUGENOMIC Genómica y Farmacogenética, Barcelona, Spain; 5Translational Medical Oncology Laboratory, Institut de Recerca Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain*These authors contributed equally to this workCorrespondence: Maria J Arranz, Research Laboratory Unit, Fundació Docència i Recerca Mútua Terrassa, c/Sant Antoni, 19, Terrassa, 08221, Spain, Tel +34 937 36 50 50, Fax +34 93 736 50 21, Email mjarranz@mutuaterrassa.esPurpose: Autistic spectrum disorders (ASD) children and adolescents usually present comorbidities, with 40– 70% of them affected by attention deficit hyperactivity disorders (ADHD). The first option of pharmacological treatment for these patients is methylphenidate (MPH). ASD children present more side effects and poorer responses to MPH than ADHD children. The objective of our study is to identify genetic biomarkers of response to MPH in ASD children and adolescents to improve its efficacy and safety.Patients and Methods: A retrospective study with a total of 140 ASD children and adolescents on MPH treatment was included. Fifteen polymorphisms within genes coding for the MPH target NET1 (SLC6A2) and for its primary metabolic pathway (CES1) were genotyped. Multivariate analyses including response phenotypes (efficacy, side-effects, presence of somnolence, irritability, mood alterations, aggressivity, shutdown, other side-effects) were performed for every polymorphism and haplotype.Results: Single marker analyses considering gender, age, and dose as covariates showed association between CES1 variants and MPH-induced side effects (rs2244613-G (p=0.04), rs2302722-C (p=0.02), rs2307235-A (p=0.03), and rs8192950-T alleles (p=0.03)), and marginal association between the CES1 rs2302722-C allele and presence of somnolence (p=0.05) and the SLC6A2 rs36029-G allele and shutdown (p=0.05). A CES1 haplotype combination was associated with efficacy and side effects (p=0.02 and 0.03 respectively). SLC6A2 haplotype combination was associated with somnolence (p=0.05).Conclusion: CES1 genetic variants may influence the clinical outcome of MPH treatment in ASD comorbid with ADHD children and adolescents.Keywords: CES1, SLC6A2, autistic spectrum disorders, ASD, methylphenidate, attention deficit hyperactivity disorders, ADHD

Published
2022

3. Ultra-processed food consumption and semen quality parameters in the Led-Fertyl study

Author

Universitat Rovira i Virgili, Valle-Hita, C; Salas-Huetos, A; de la Puente, MF; Martínez, MA; Canudas, S; Palau-Galindo, A; Mestres, C; Manzanares, JM; Murphy, MM; Marquès, M; Salas-Salvadó, J; Babio, N, Universitat Rovira i Virgili, and Valle-Hita, C; Salas-Huetos, A; de la Puente, MF; Martínez, MA; Canudas, S; Palau-Galindo, A; Mestres, C; Manzanares, JM; Murphy, MM; Marquès, M; Salas-Salvadó, J; Babio, N

Abstract

STUDY QUESTION Is ultra-processed food (UPF) consumption associated with semen quality parameters?SUMMARY ANSWER Higher UPF consumption was inversely associated with total sperm count, sperm concentration, and total motility in men of reproductive age.WHAT IS KNOWN ALREADY The consumption of UPF, which has been rising during the last decades, has been demonstrated to be positively associated with several chronic diseases such as diabetes or cardiovascular diseases. However, the scientific evidence on its potential impact on semen quality remains notably limited.STUDY DESIGN, SIZE, DURATION A cross-sectional analysis was conducted using data from 200 healthy men (mean age 28.4 +/- 5.5 years) enrolled in the Led-Fertyl (Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters) study between February 2021 and April 2023.PARTICIPANTS/MATERIALS, SETTING, METHODS UPF consumption (% of energy from UPF) was estimated according to the NOVA classification system using a validated 143-item semi-quantitative food frequency questionnaire. Total sperm count, sperm concentration, sperm vitality, total motility, progressive motility, and normal sperm forms were set as the main outcomes. Microscopic parameters were analyzed using a phase-contrast microscope and a computer-assisted sperm analysis (CASA) system. Semen samples were collected and tested according to World Health Organization 2010 standards. Multivariable linear regression models were fitted to estimate the associations between UPF tertile and semen quality parameters.MAIN RESULTS AND THE ROLE OF CHANCE Sperm concentration (beta: -1.42 x 106 spz./ml; 95% CI: -2.72 to -0.12) and motility (beta: -7.83%; 95% CI: -15.16 to -0.51) were lower in participants in the highest tertile of UPF c

Published
2024

5. Prevalence of Structural Heart Diseases Detected by Handheld Echocardiographic Device in School-Age Children in Iran: The SHED LIGHT Study

Author

Hosseini, S, Samiei, N, Tabib, A, Bakhshandeh, H, Rezaei, Y, Parsaee, M, Ghader, F, Moradian, M, Shojaeifard, M, Khajali, Z, Taghavi, S, Naderi, N, Hejri, G, Ghaderian, H, Houshmand, G, Kaviani, R, Farrashi, M, Pakbaz, M, Mombeini, H, Saedi, S, Ghavidel, A, Omrani, G, Mohebbi, A, Peighambari, M, Khorgami, M, Nikpajouh, A, Amin, A, Maleki, M, Mestres, C, Badano, L, Noohi, F, Hosseini S., Samiei N., Tabib A., Bakhshandeh H., Rezaei Y., Parsaee M., Ghader F. R., Moradian M., Shojaeifard M., Khajali Z., Taghavi S., Naderi N., Hejri G. M., Ghaderian H., Houshmand G., Kaviani R., Farrashi M., Pakbaz M., Mombeini H., Saedi S., Ghavidel A. A., Omrani G., Mohebbi A., Peighambari M. M., Khorgami M. R., Nikpajouh A., Amin A., Maleki M., Mestres C. A., Badano L, Noohi F., Hosseini, S, Samiei, N, Tabib, A, Bakhshandeh, H, Rezaei, Y, Parsaee, M, Ghader, F, Moradian, M, Shojaeifard, M, Khajali, Z, Taghavi, S, Naderi, N, Hejri, G, Ghaderian, H, Houshmand, G, Kaviani, R, Farrashi, M, Pakbaz, M, Mombeini, H, Saedi, S, Ghavidel, A, Omrani, G, Mohebbi, A, Peighambari, M, Khorgami, M, Nikpajouh, A, Amin, A, Maleki, M, Mestres, C, Badano, L, Noohi, F, Hosseini S., Samiei N., Tabib A., Bakhshandeh H., Rezaei Y., Parsaee M., Ghader F. R., Moradian M., Shojaeifard M., Khajali Z., Taghavi S., Naderi N., Hejri G. M., Ghaderian H., Houshmand G., Kaviani R., Farrashi M., Pakbaz M., Mombeini H., Saedi S., Ghavidel A. A., Omrani G., Mohebbi A., Peighambari M. M., Khorgami M. R., Nikpajouh A., Amin A., Maleki M., Mestres C. A., Badano L, and Noohi F.

Abstract

Background: Structural heart disease (SHD) has great impacts on healthcare systems, creating further public health concerns. Proper data are scant regarding the magnitude of the affected population by SHD. Objectives: This study aimed to determine the prevalence of SHD among children and adolescents in an Iranian population. Methods: In this population-based study, a multistage cluster-random sampling was used to choose schools from the Tehran urban area. All students were examined using a handheld Vscan device by echocardiographer, and the results were concurrently supervised and interpreted by cardiologists. All the major findings were reevaluated in hospital clinics. Results: Of 15,130 students (6–18 years, 52.2% boys) who were examined, the prevalence of individuals with congenital heart disease (CHD) and cardiomyopathy was 152 (10.046 per 1,000 persons) and 9 (0.595 per 1,000 persons), respectively. The prevalence of definite and borderline rheumatic heart disease (RHD) was 30 (2 per 1,000 persons) and 113 (7.5 per 1,000 persons), correspondingly. Non-rheumatic valvular heart disease (VHD) was also detected in 465 (30.7 per 1,000 persons) students. Of all the pathologies, only 39 (25.6%) cases with CHD and 1 (0.007%) cases with RHD had already been diagnosed. Parental consanguinity was the strongest predictor of CHD and SHD (odds ratio [OR]: 1.907, 95% CI, 1.358 to 2.680; P < 0.001 and OR, 1.855, 95% CI, 1.334 to 2.579; P < 0.001, respectively). The female sex (OR, 1.262, 95% CI, 1.013 to 1.573; P = 0.038) and fathers’ low literacy (OR, 1.872, 95% CI, 1.068 to 3.281; P = 0.029) were the strongest predictors of non-rheumatic VHD and RHD, correspondingly. Conclusions: The implementation of echocardiographic examinations for detecting SHD among young population is feasible which detected SHD prevalence in our population comparable to previous reports. Further studies are required to delineate its economic aspects for community-based screening.

Published
2022

6. 2023 ESC Guidelines for the management of endocarditis

Author

Delgado, V, Ajmone Marsan, N, de Waha, S, Bonaros, N, Brida, M, Burri, H, Caselli, S, Doenst, T, Ederhy, S, Erba, P, Foldager, D, Fosbøl, E, Kovac, J, Mestres, C, Miller, O, Miro, J, Pazdernik, M, Pizzi, M, Quintana, E, Rasmussen, T, Ristić, A, Rodés-Cabau, J, Sionis, A, Zühlke, L, Borger, M, Delgado, Victoria, Ajmone Marsan, Nina, de Waha, Suzanne, Bonaros, Nikolaos, Brida, Margarita, Burri, Haran, Caselli, Stefano, Doenst, Torsten, Ederhy, Stephane, Erba, Paola Anna, Foldager, Dan, Fosbøl, Emil L, Kovac, Jan, Mestres, Carlos A, Miller, Owen I, Miro, Jose M, Pazdernik, Michal, Pizzi, Maria Nazarena, Quintana, Eduard, Rasmussen, Trine Bernholdt, Ristić, Arsen D, Rodés-Cabau, Josep, Sionis, Alessandro, Zühlke, Liesl Joanna, Borger, Michael A, Delgado, V, Ajmone Marsan, N, de Waha, S, Bonaros, N, Brida, M, Burri, H, Caselli, S, Doenst, T, Ederhy, S, Erba, P, Foldager, D, Fosbøl, E, Kovac, J, Mestres, C, Miller, O, Miro, J, Pazdernik, M, Pizzi, M, Quintana, E, Rasmussen, T, Ristić, A, Rodés-Cabau, J, Sionis, A, Zühlke, L, Borger, M, Delgado, Victoria, Ajmone Marsan, Nina, de Waha, Suzanne, Bonaros, Nikolaos, Brida, Margarita, Burri, Haran, Caselli, Stefano, Doenst, Torsten, Ederhy, Stephane, Erba, Paola Anna, Foldager, Dan, Fosbøl, Emil L, Kovac, Jan, Mestres, Carlos A, Miller, Owen I, Miro, Jose M, Pazdernik, Michal, Pizzi, Maria Nazarena, Quintana, Eduard, Rasmussen, Trine Bernholdt, Ristić, Arsen D, Rodés-Cabau, Josep, Sionis, Alessandro, Zühlke, Liesl Joanna, and Borger, Michael A

Published
2023

7. Association of monetary diet cost of foods and diet quality in Spanish older adults

Author

Universitat Rovira i Virgili, Bouzas, C; Pastor, R; Garcia, S; Monserrat-Mesquida, M; Martinez-Gonzalez, MA; Salas-Salvado, J; Corella, D; Schröder, H; Martinez, JA; Alonso-Gomez, AM; Wärnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Riquelme-Gallego, B; Romero-Secin, A; Pinto, X; Gaforio, JJ; Matia, P; Vidal, J; Zapatero, M; Daimiel, L; Ros, E; Garcia-Arellano, A; Babio, N; Gonzalez-Monje, I; Castañer, O; Abete, I; Tojal-Sierra, L; Benavente-Marin, JC; Signes-Pastor, A; Konieczna, J; Garcia-Rios, A; Castro-Barquero, S; Fernandez-Garcia, JC; Santos-Lozano, JM; Bes-Rastrollo, M; Mestres, C; Guillem-Saiz, P; Goday, A; Goicolea-Güemez, L; Puig-Aguilo, E; Ruiz-Canela, M; Palau-Galindo, A; Fito, M; Tur, JA, Universitat Rovira i Virgili, and Bouzas, C; Pastor, R; Garcia, S; Monserrat-Mesquida, M; Martinez-Gonzalez, MA; Salas-Salvado, J; Corella, D; Schröder, H; Martinez, JA; Alonso-Gomez, AM; Wärnberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, L; Riquelme-Gallego, B; Romero-Secin, A; Pinto, X; Gaforio, JJ; Matia, P; Vidal, J; Zapatero, M; Daimiel, L; Ros, E; Garcia-Arellano, A; Babio, N; Gonzalez-Monje, I; Castañer, O; Abete, I; Tojal-Sierra, L; Benavente-Marin, JC; Signes-Pastor, A; Konieczna, J; Garcia-Rios, A; Castro-Barquero, S; Fernandez-Garcia, JC; Santos-Lozano, JM; Bes-Rastrollo, M; Mestres, C; Guillem-Saiz, P; Goday, A; Goicolea-Güemez, L; Puig-Aguilo, E; Ruiz-Canela, M; Palau-Galindo, A; Fito, M; Tur, JA

Abstract

Background: A major barrier to a healthy diet may be the higher price of healthy foods compared to low-quality foods. Objectives: This study aimed to assess the association between the monetary cost of food and diet quality in Spanish older adults at high risk of cardiovascular disease. Methods: Cross-sectional analysis was carried out in Spanish older adults (n = 6,838; 48.6% female). A validated food frequency questionnaire was used to assess dietary intake. Metabolic syndrome severity, adherence to the Mediterranean diet (MedDiet), adherence to a provegetarian dietary pattern, and dietary inflammatory index were assessed. The economic cost of the foods was obtained from the Spanish Ministry of Agriculture Fisheries and Food database (2015–2017, the period of time when the participants were recruited). The total cost of diet adjusted per 1,000 kcal was computed. Results: The healthier dietary pattern was associated with a higher cost of the diet. Higher adherence to the MedDiet, anti-inflammatory diet, and the healthy version of the provegetarian dietary pattern were related to higher costs of the diet. Conclusion: Higher diet quality was associated with a higher dietary cost of the diet per 1,000 kcal/day. Food prices can be an important component of interventions and policies aimed at improving people's diets and preventing diet-related chronic diseases. Clinical trial registry number: The trial was registered in 2014 at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870) with the number 89898870.

Published
2023

17. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population

Author

Paz-Graniel, I, Babio, N, Becerra-Tomas, N, Toledo, E, Camacho-Barcia, L, Corella, D, Castaner-Nino, O, Romaguera, D, Vioque, J, Alonso-Gomez, AM, Warnberg, J, Martinez, JA, Serra-Majem, L, Estruch, R, Tinahones, FJ, Fernandez-Aranda, F, Lapetra, J, Pinto, X, Tur, JA, Garcia-Rios, A, Bueno-Cavanillas, A, Gaforio, JJ, Matia-Martin, P, Daimiel, L, Sanchez, VM, Vidal, J, Prieto-Sanchez, L, Ros, E, Razquin, C, Mestres, C, Sorli, JV, Cuenca-Royo, AM, Rios, A, Torres-Collado, L, Vaquero-Luna, J, Perez-Farinos, N, Zulet, MA, Sanchez-Villegas, A, Casas, R, Bernal-Lopez, MR, Santos-Lozano, JM, Corbella, X, Mateos, D, Buil-Cosiales, P, Jimenez-Murcia, S, Fernandez-Carrion, R, Forcano-Gamazo, L, Lopez, M, Sempere-Pascual, MA, Moreno-Rodriguez, A, Gea, A, De la Torre-Fornell, R, Salas-Salvado, J, Perez, A, and Lozano Madrid, Maria

Subjects
Cognitive impairment, Caffeine, Mini-Mental State Examination, PREDIMED-plus, Coffee
Abstract

Purpose Coffee is rich in compounds such as polyphenols, caffeine, diterpenes, melanoidins and trigonelline, which can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable research interest. In this paper, we assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS). Methods PREDIMED-plus study participants who completed the Mini-Mental State Examination test (MMSE) (n = 6427; mean age = 65 +/- 5 years) or a battery of neuropsychological tests were included in this cross-sectional analysis. Coffee consumption and total dietary caffeine intake were assessed at baseline using a food frequency questionnaire. Logistic regression models were fitted to evaluate the association between total, caffeinated and decaffeinated coffee consumption or total dietary caffeine intake and cognitive impairment. Results Total coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers when measured by the MMSE and after adjusting for potential confounders (OR 0.63; 95% CI 0.44-0.90 and OR 0.56; 95% CI 0.38-0.83, respectively). Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. Participants in the highest tertile of total dietary caffeine intake had lower odds of poor cognitive functioning than those in the reference tertile when screened by the MMSE (OR 0.64; 95% CI 0.47-0.87) or other neurophysiological tests evaluating a variety of cognitive domains (i.e., CDT and TMT-A). Conclusions Coffee consumption and total dietary caffeine intake were associated with better cognitive functioning as measured by various neuropsychological tests in a Mediterranean cohort of elderly individuals with MetS.

Published
2021

18. The Impact of Pharmaceutical Care in Multidisciplinary Teams on Health Outcomes: Systematic Review and Meta-Analysis

Author

Hernandez, MH, Juanes-Borrego, AM, Mila, R, Mangues-Bafalluy, MA, and Mestres, C

Subjects
pharmacist, Patient team care, polypharmacy, chronic disease
Abstract

Objectives: Pharmacists' care has an essential role in multidisciplinary teams in charge of chronic pa-tients. However, data available on the clinical outcomes of these activities appear inconclusive. This study aimed to systematically investigate the effect of multidisciplinary teams that include coordinated pharmaceutical care on clinical outcomes. Design: Systematic review and meta-analysis. Relevant studies identified from MEDLINE, Cochrane, Web of Science, Scopus and CINAHL databases were analyzed. The search included randomized clinical trials published in 2000-2018. Included studies were all published studies in English that compared the effectiveness of multidisciplinary teams including pharmacist care to usual care. Meta-analysis was carried out using a random effects model, and subgroup analysis was conducted to determine the sources of heterogeneity. Setting and Participants: 29 studies involving 4186 adult patients were included. Measures: Follow-up time varied from 30 to 180 days. The most common primary endpoint was the frequency of hospitalizations or readmissions, followed by variation in clinical parameter variables related to quality of prescription, treatment adherence and costs. Results: Twelve (41.3%) of the included studies scored low risk of bias according to the AMSTAR-2 scale, the remaining 17 (58.7%) being classified as intermediate risk. The intervention of a multidisciplinary team reduced the probability of readmission by 32% [odds ratio (OR) 0.74, 95% confidence interval (CI) 0.62-0.89]. Six of the 29 (20.7%) studies included met the inclusion criteria of the meta-analysis on quality-of-life outcomes. The intervention of the multidisciplinary team represented a significant in-crease in patients' quality of life (OR 0.58, 95% CI 0.47-0.69). Analysis of heterogeneity showed a sig-nificant difference between the studies. No evidence of publication bias was identified. Conclusions and Implications: Multidisciplinary programs that include pharmaceutical care reduce the risk of visiting hospitals and improve patients' quality of life. This review supports the importance of the pharmacists as part of multidisciplinary teams. (c) 2021 AMDA -The Society for Post-Acute and Long-Term Care Medicine.

Published
2021

19. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population

Author

Universitat Rovira i Virgili, Paz-Graniel, I; Babio, N; Becerra-Tomás, N; Toledo, E; Camacho-Barcia, L; Corella, D; Castañer-Niño, O; Romaguera, D; Vioque, J; Alonso-Gómez, AM; Wärnberg, J; Martínez, JA; Serra-Majem, L; Estruch, R; Tinahones, FJ; Fernandez-Aranda, F; Lapetra, J; Pintó, X; Tur, JA; García-Rios, A; Bueno-Cavanillas, A; Gaforio, JJ; Matía-Martín, P; Daimiel, L; Sanchez, VM; Vidal, J; Prieto-Sanchez, L; Ros, E; Razquin, C; Mestres, C; Sorli, JV; Cuenca-Royo, AM; Rios, A; Torres-Collado, L; Vaquero-Luna, J; Pérez-Farinós, N; Zulet, MA; Sanchez-Villegas, A; Casas, R; Bernal-Lopez, MR; Santos-Lozano, JM; Corbella, X; Mateos, D; Buil-Cosiales, P; Jimenez-Murcia, S; Fernandez-Carrion, R; Forcano-Gamazo, L; López, M; Sempere-Pascual, MA; Moreno-Rodriguez, A; Gea, A; De la Torre-Fornell, R; Salas-Salvadó, J, Universitat Rovira i Virgili, and Paz-Graniel, I; Babio, N; Becerra-Tomás, N; Toledo, E; Camacho-Barcia, L; Corella, D; Castañer-Niño, O; Romaguera, D; Vioque, J; Alonso-Gómez, AM; Wärnberg, J; Martínez, JA; Serra-Majem, L; Estruch, R; Tinahones, FJ; Fernandez-Aranda, F; Lapetra, J; Pintó, X; Tur, JA; García-Rios, A; Bueno-Cavanillas, A; Gaforio, JJ; Matía-Martín, P; Daimiel, L; Sanchez, VM; Vidal, J; Prieto-Sanchez, L; Ros, E; Razquin, C; Mestres, C; Sorli, JV; Cuenca-Royo, AM; Rios, A; Torres-Collado, L; Vaquero-Luna, J; Pérez-Farinós, N; Zulet, MA; Sanchez-Villegas, A; Casas, R; Bernal-Lopez, MR; Santos-Lozano, JM; Corbella, X; Mateos, D; Buil-Cosiales, P; Jimenez-Murcia, S; Fernandez-Carrion, R; Forcano-Gamazo, L; López, M; Sempere-Pascual, MA; Moreno-Rodriguez, A; Gea, A; De la Torre-Fornell, R; Salas-Salvadó, J

Abstract

Purpose Coffee is rich in compounds such as polyphenols, caffeine, diterpenes, melanoidins and trigonelline, which can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable research interest. In this paper, we assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS). Methods PREDIMED-plus study participants who completed the Mini-Mental State Examination test (MMSE) (n = 6427; mean age = 65 +/- 5 years) or a battery of neuropsychological tests were included in this cross-sectional analysis. Coffee consumption and total dietary caffeine intake were assessed at baseline using a food frequency questionnaire. Logistic regression models were fitted to evaluate the association between total, caffeinated and decaffeinated coffee consumption or total dietary caffeine intake and cognitive impairment. Results Total coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers when measured by the MMSE and after adjusting for potential confounders (OR 0.63; 95% CI 0.44-0.90 and OR 0.56; 95% CI 0.38-0.83, respectively). Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. Participants in the highest tertile of total dietary caffeine intake had lower odds of poor cognitive functioning than those in the reference tertile when screened by the MMSE (OR 0.64; 95% CI 0.47-0.87) or other neurophysiological tests evaluating a variety of cognitive domains (i.e., CDT and TMT-A). Conclusions Coffe

Published
2021

23. Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database

Author

Lalani, T., Kanafani, Z. A., Chu, V. H., Moore, L., Corey, G. R., Pappas, P., Woods, C. W., Cabell, C. H., Hoen, B., Selton-Suty, C., Doco-Lecompte, T., Chirouze, C., Raoult, D., Miro, J. M., Mestres, C. A., Olaison, L., Eykyn, S., Abrutyn, E., Fowler, Jr, V. G., and The International Collaboration on Endocarditis Merged Database Study Group

Published
2006
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24. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

Author

Hasse, B., Hannan, M. M., Keller, P. M., Maurer, F. P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Hernandez Conte, A., Durante-Mangoni, E., Tang, T. H.C., Stuart, R. L., Lundgren, J., Gordon, S., Jarashow, M. C., Schreiber, P. W., Niemann, S., Kohl, T. A., Daley, C. L., Stewardson, A. J., Whitener, C. J., Perkins, K., Plachouras, D., Lamagni, T., Chand, M., Freiberger, T., Zweifel, S., Sander, P., Schulthess, B., Scriven, J. E., Sax, H., van Ingen, J., Mestres, C. A., Diekema, D., Brown-Elliott, B. A., Wallace, R. J., Baddour, L. M., Miro, J. M., Hoen, B., Hasse, B., Hannan, M. M., Keller, P. M., Maurer, F. P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Hernandez Conte, A., Durante-Mangoni, E., Tang, T. H.C., Stuart, R. L., Lundgren, J., Gordon, S., Jarashow, M. C., Schreiber, P. W., Niemann, S., Kohl, T. A., Daley, C. L., Stewardson, A. J., Whitener, C. J., Perkins, K., Plachouras, D., Lamagni, T., Chand, M., Freiberger, T., Zweifel, S., Sander, P., Schulthess, B., Scriven, J. E., Sax, H., van Ingen, J., Mestres, C. A., Diekema, D., Brown-Elliott, B. A., Wallace, R. J., Baddour, L. M., Miro, J. M., and Hoen, B.

Abstract

Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects.

Published
2020

25. Prognostic assessment of valvular surgery in active infective endocarditis: multicentric nationwide validation of a new score developed from a meta-analysisis

Author

Varela Barca, Laura, Fernández-Felix, Borja M., Navas, Enrique, Mestres, C. A., Muñoz García, Patricia, Cuerpo Caballero, Gregorio, Rodríguez-Abella, Hugo, Montejo, Miguel, Rodríguez-Álvarez, Regino José, Gutiérrez Díez, Francisco, Goenaga Sánchez, Miguel Ángel, Quintana, Eduardo, Ojeda Burgos, Guillermo, Alarcón González, Arístides de, Vidal Bonet, Laura, Centella, Tomasa, López-Menéndez, José, Varela Barca, Laura, Fernández-Felix, Borja M., Navas, Enrique, Mestres, C. A., Muñoz García, Patricia, Cuerpo Caballero, Gregorio, Rodríguez-Abella, Hugo, Montejo, Miguel, Rodríguez-Álvarez, Regino José, Gutiérrez Díez, Francisco, Goenaga Sánchez, Miguel Ángel, Quintana, Eduardo, Ojeda Burgos, Guillermo, Alarcón González, Arístides de, Vidal Bonet, Laura, Centella, Tomasa, and López-Menéndez, José

Abstract

[Objectives] Several risk prediction models have been developed to estimate the risk of mortality after valve surgery for active infective endocarditis (IE), but few external validations have been conducted to assess their accuracy. We previously developed a systematic review and meta-analysis of the impact of IE-specific factors for the in-hospital mortality rate after IE valve surgery, whose obtained pooled estimations were the basis for the development of a new score (APORTEI). The aim of the present study was to assess its prognostic accuracy in a nationwide cohort., [Methods] We analysed the prognostic utility of the APORTEI score using patient-level data from a multicentric national cohort. Patients who underwent surgery for active IE between 2008 and 2018 were included. Discrimination was evaluated using the area under the receiver operating characteristic curve, and the calibration was assessed using the calibration slope and the Hosmer–Lemeshow test. Agreement between the APORTEI and the EuroSCORE I was also analysed by Lin’s concordance correlation coefficient (CCC), the Bland–Altman agreement analysis and a scatterplot graph., [Results] The 11 variables that comprised the APORTEI score were analysed in the sample. The APORTEI score was calculated in 1338 patients. The overall observed surgical mortality rate was 25.56%. The score demonstrated adequate discrimination (area under the receiver operating characteristic curve = 0.75; 95% confidence interval 0.72–0.77) and calibration (calibration slope = 1.03; Hosmer–Lemeshow test P = 0.389). We found a lack of agreement between the APORTEI and EuroSCORE I (concordance correlation coefficient = 0.55)., [Conclusions] The APORTEI score, developed from a systematic review and meta-analysis, showed an adequate estimation of the risk of mortality after IE valve surgery in a nationwide cohort.

Published
2020

26. Infective endocarditis in patients with cardiac implantable electronic devices: a nationwide study

Author

Mateos Gaitán, Roberto, Boix-Palop, Lucía, Muñoz García, Patricia, Mestres, C. A., Marín-Arriaza, Mercedes, Pedraz Prieto, Álvaro, Alarcón González, Arístides de, Gutiérrez-Carretero, Encarnación, Hernández-Meneses, Marta, Goenaga Sánchez, Miguel Ángel, Cobo Belaustegui, Manuel, Oteo, José Antonio, Gainzarain Arana, Juan Carlos, García Vázquez, Elisa, Martínez-Sellés, Manuel, Mateos Gaitán, Roberto, Boix-Palop, Lucía, Muñoz García, Patricia, Mestres, C. A., Marín-Arriaza, Mercedes, Pedraz Prieto, Álvaro, Alarcón González, Arístides de, Gutiérrez-Carretero, Encarnación, Hernández-Meneses, Marta, Goenaga Sánchez, Miguel Ángel, Cobo Belaustegui, Manuel, Oteo, José Antonio, Gainzarain Arana, Juan Carlos, García Vázquez, Elisa, and Martínez-Sellés, Manuel

Abstract

[Aims] Patients with infective endocarditis (IE) frequently have cardiac implantable electronic devices (CIEDs). Here, we aim to define the clinical profile and prognostic factors of IE in these patients., [Methods and results] Infective endocarditis cases were prospectively identified in the Spanish National Endocarditis Registry. From 3996 IE, 708 (17.7%) had a CIED and 424 CIED-related IE (lead vegetation). Patients with a CIED were older (68 ± 11 vs. 73 ± 8 years); had more comorbidities {pulmonary disease [176 (24.8%) vs. 545 (16.7%)], renal disease [239 (33.8%) vs. 740 (22.7%)], diabetes [248 (35.0%) vs. 867 (26.6%)], and heart failure [348 (49.2%) vs. 978 (29.9%)]}; and fewer complications {intracardiac destruction [106 (15%) vs. 1077 (33.1%)], heart failure [215 (30.3%) vs. 1340 (41.1%)], embolism [107 (15.1%) vs. 714 (21.9%)], and neurological involvement [77 (10.8%) vs. 702 (21.5%)]} (all P-values <0.001) in comparison to subjects without a CIED. In-hospital mortality was similar in patients with and without CIED [171 (24.2%) vs. 881 (27.0%), P = 0.82]. In subjects with a CIED, CIED-related IE was independently associated with in-hospital survival: odds ratio (OR) 0.4 [95% confidence interval (CI) 0.3–0.7, P = 0.001]. Surgery was independently associated with in-hospital survival in CIED-related IE: OR 0.4 (95% CI 0.2–0.7, P = 0.004); but not in subjects with valve IE and no CIED lead involvement: OR 0.9 (95% CI 0.5–1.7, P = 0.77)., [Conclusion] Over a sixth of IE patients have a CIED. This group of patients is older, with more comorbidities and fewer IE-related complications in comparison to subjects without a CIED. In-hospital mortality was similar in patients with and without a CIED.

Published
2020

32. Mitral valve repair in infective endocarditis is not inferior to valve replacement: results from a Spanish nationwide prospective registry

Author

Cuerpo G, Valerio M, Pedraz A, Rodriguez-Abella H, Mestres C, Obrador E, Gonzalez-Calle A, Alvarez R, Garcia P, Bouza E, Sanchez F, Noureddine M, Rosas G, Lima J, Aramendi J, Bereciartua E, Blanco M, Blanco R, Boado M, Lazaro M, Crespo A, Goikoetxea J, Iruretagoyena J, Zuazabal J, Lopez-Soria L, Montejo M, Nieto J, Rodrigo D, Rodriguez D, Rodriguez R, Vitoria Y, Voces R, Lopez M, Georgieva R, Ojeda G, Bailon I, Morales J, Cuende A, Echeverria T, Fuerte A, Gaminde E, Goenaga M, Idigoras P, Iribarren J, Yarza A, Urkola X, Reviejo C, Carrasco R, Climent V, Llamas P, Merino E, Plazas J, Reus S, Alvarez N, Bravo-Ferrer J, Castelo L, Cuenca J, Llinares P, Rey E, Mayo M, Sanchez E, Regueiro D, Martinez F, Alonso M, Castro B, Rosado D, Duran M, Gomez M, Lacalzada J, Nassar I, Ciezar A, Iglesias J, Alvarez V, Costas C, de la Hera J, Suarez J, Fraile L, Arguero V, Menendez J, Bajo P, Morales C, Torrico A, Palomo C, Martinez B, Esteban A, Garcia R, Asensio M, Almela M, Ambrosioni J, Azqueta M, Brunet M, Bodro M, Cartana R, Falces C, Fita G, Fuster D, de la Maria C, Hernandez-Meneses M, Perez J, Marco F, Miro J, Moreno A, Nicolas D, Ninot S, Quintana E, Pare C, Pereda D, Pericas J, Pomar J, Ramirez J, Rovira I, Sandoval E, Sitges M, Soy D, Tellez A, Tolosana J, Vidal B, Vila J, Adan I, Bermejo J, Celemin D, Caballero G, Pinto A, Montero A, Cruz A, Mansilla A, Leoni M, Ramallo V, Hernandez M, Hualde A, Marin M, Martinez-Selles M, Menarguez M, Munoz P, Rincon C, Rodriguez-Creixems M, Pinilla B, Vazquez P, Moreno E, Antorrena I, Loeches B, Quiros A, Moreno M, Ramirez U, Baston V, Romero M, Saldana A, Balbin J, Castillo C, Arnaiz A, Revillas F, Belaustegui M, Farinas M, Farinas-Alvarez C, Izquierdo R, Garcia I, Rico C, Gutierrez-Cuadra M, Diez J, Pajaron M, Parra J, Teira R, Zarauza J, Dominguez F, Pavia P, Gonzalez J, Orden B, Ramos A, Centella T, Hermida J, Moya J, Martin-Davila P, Navas E, Oliva E, del Rio A, Ruiz S, Tenorio C, Delia M, Araji O, Barquero J, Jambrina R, de Cueto M, Acebal J, Mendez I, Morales I, Lopez-Cortes L, de Alarcon A, Garcia E, Haro J, Lepe J, Lopez F, Luque R, Alonso L, Azcarate P, Gutierrez J, Blanco J, Villegas A, Garcia-Alvarez L, Oteo J, Sanz M, de Benito N, Gurgui M, Pacho C, Pericas R, Pons G, Alvarez M, Fernandez A, Martinez A, Prieto A, Regueiro B, Tijeira E, Vega M, Blasco A, Mollar J, Arana J, Uriarte O, Lopez A, de Zarate Z, Matos J, Dominguez G, Sanchez-Porto A, Leal J, Vazquez E, Torres A, Blazquez A, Valenzuela G, Alonso A, Aramburu J, Calvo F, Rodriguez A, Tarabini-Castellani P, Galvez E, Bellido C, Pau J, Sepulveda M, Sierra P, Iqbal-Mirza S, Alcolea E, Yanez I, Ballesta A, Escobar E, Monje A, Cabrera V, Garcia D, Asenjo M, Luna C, Morcillo J, Seco M, Gelabert A, Guallar C, Abad N, Mangas P, Adell M, Ruiz M, Porres J, Trigueros N, Espin M, Caro J, Sanchez R, Almazan A, Freire A, Gonzalez M, Ramis P, Bordes E, Bonet L, Munera M, Garaizabal E, Luque J, and GAMEs Study Grp

Subjects
Infectious endocarditis, Mitral valve reparation, Cardiac surgery, Mitral valve replacement
Abstract

IntroductionInfective endocarditis (IE) still carries high morbidity and mortality and frequently requires surgery. The benefit of mitral valve repair (MVr) in the setting of IE is yet to be proven. The goal of this study was to assess the results of MVr in patients with IE after a minimum follow-up of 1year.MethodsThis study is based on a Spanish nationwide prospective registry that included patients operated on for native mitral valve IE. The collaborating Institutions pooled their pre-, peri-, and postoperative data into the database of the GAMES group [Grupo de Apoyo al Manejo de la EndocarditiS (Group for support and management of infective endocarditis)].ResultsData from 27 hospitals were recorded and 3524 cases of active IE identified between 2008 and 2016. There were 1513 cases of mitral IE, of which 898 involved native valves. Of these, 437 patients underwent surgical treatment, and 369 completed the 1-year follow-up. The valve was repaired in 68 cases (18.4%). Preoperative groups were comparable (EuroSCORE MVr 7.7 vs MVR 8.0; p=ns). Mortality in the repair group was inferior to that in the replacement group (16.2% vs 27.2%, p=0.058). At 1year, mortality remained higher in the replacement group: 3.7% vs 2.9%. Relapse of the infection was slightly more frequent in the repair group (7.1% vs 3.7%; p=ns), although this did not lead to higher rates of reintervention (MVr/MVR: 2.9% vs 4.9%).ConclusionMVr is an attractive option for specific patients with IE and does not seem to negatively impact on relapses.

Published
2019

38. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Association for Cardiothoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM)

Author

Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., Walker D. M., Habib, G., Lancellotti, P., Antunes, M. J., Bongiorni, M. G., Casalta, J. -P., Del Zotti, F., Dulgheru, R., El Khoury, G., Erba, P. A., Iung, B., Miro, J. M., Mulder, B. J., Plonska-Gosciniak, E., Price, S., Roos-Hesselink, J., Snygg-Martin, U., Thuny, F., Mas, P. T., Vilacosta, I., Zamorano, J. L., Erol, C., Nihoyannopoulos, P., Aboyans, V., Agewall, S., Athanassopoulos, G., Aytekin, S., Benzer, W., Bueno, H., Broekhuizen, L., Carerj, S., Cosyns, B., De Backer, J., De Bonis, M., Dimopoulos, K., Donal, E., Drexel, H., Flachskampf, F. A., Hall, R., Halvorsen, S., Hoen, B., Kirchhof, P., Lainscak, M., Leite-Moreira, A. F., Lip, G. Y. H., Mestres, C. A., Piepoli, M. F., Punjabi, P. P., Rapezzi, C., Rosenhek, R., Siebens, K., Tamargo, J., Walker, D. M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, and Walker, D

Subjects
Algorithm, Heart Valve Disease, Decision Tree, Decision Trees, Heart Valve Diseases, Humans, Endocarditis, Bacterial, Prognosis, Algorithms, Human
Published
2016

41. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Association for Cardiothoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM) [Linee guida ESC 2015 per il trattamento dell'endocardite infettiva: Task Force per il Trattamento dell'Endocardite Infettiva della Società Europea di Cardiologia (ESC): Con il patrocinio dell'Associazione Europea di Chirurgia Cardiotoracica (EACTS) e dell'Associazione Europea di Medicina Nucleare (EANM)]

Author

Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., Walker D. M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., and Walker D. M.

Published
2016

45. Efficacy and safety of fosfomycin plus imipenem versus vancomycin for complicated bacteraemia and endocarditis due to methicillin-resistant Staphylococcus aureus: a randomized clinical trial

Author

Ministerio de Sanidad y Consumo (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Institut d'Investigacions Biomèdiques August Pi i Sunyer, European Society of Clinical Microbiology and Infectious Diseases, Federation of European Microbiological Societies, Pericás Pulico, Juan Manuel, Moreno, Asunción, Almela, Manel, García-de-la-Mària, Cristina, Marco, Francesc, Muñoz García, Patricia, Peña, Carmen, Alarcón González, Arístides de, Río, A. del, Eworo, A., Cruceta, A., Paré, J. C., Mestres, C. A., Miró, José María, Ministerio de Sanidad y Consumo (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Institut d'Investigacions Biomèdiques August Pi i Sunyer, European Society of Clinical Microbiology and Infectious Diseases, Federation of European Microbiological Societies, Pericás Pulico, Juan Manuel, Moreno, Asunción, Almela, Manel, García-de-la-Mària, Cristina, Marco, Francesc, Muñoz García, Patricia, Peña, Carmen, Alarcón González, Arístides de, Río, A. del, Eworo, A., Cruceta, A., Paré, J. C., Mestres, C. A., and Miró, José María

Published
2018

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