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24 results on '"Messner, Moritz"'

3. Prevalence and outcome of coronary artery disease in cardiac amyloidosis: A retrospective Austrian multicenter study

Author

Ungericht, Maria, primary, Messner, Moritz, primary, Puelacher, Christian, primary, Schuetz, Thomas, primary, Staggl, Simon, primary, Zaruba, Marc-Michael, primary, Willenbacher, Wolfgang, primary, Weger, Roman, primary, Rittler, Sarah, primary, Agis,, Hermine, primary, Krauth, Maria-Theresia, primary, Weber, Thomas, primary, Höller, Viktoria, primary, Verheyen, Nicolas, primary, Ebner, Christian, primary, Strassl, Irene, primary, Pichler, Petra, primary, Darling, Philipp, primary, and Pölzl, Gerhard, primary

Published
2024
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4. Roxadustat Attenuates Adverse Remodeling Following Myocardial Infarction in Mice.

Author

Zaruba, Marc-Michael, Staggl, Simon, Ghadge, Santhosh Kumar, Maurer, Thomas, Gavranovic-Novakovic, Jasmina, Jeyakumar, Vivek, Schönherr, Patric, Wimmer, Andreas, Pölzl, Gerhard, Bauer, Axel, and Messner, Moritz

Subjects
ACUTE coronary syndrome, GENE expression, MYOCARDIAL infarction, CELL migration, ANEMIA treatment
Abstract

Activation of the CXCL12/CXCR4/ACKR3 axis is known to aid myocardial repair through ischemia-triggered hypoxia-inducible factor-1α (HIF-1α). To enhance the upregulation of HIF-1α, we administered roxadustat, a novel prolyl hydroxylase inhibitor (PHI) clinically approved by the European Medicines Agency 2021 for the treatment of renal anemia, with the purpose of improving LV function and attenuating ischemic cardiomyopathy. Methods: We evaluated roxadustat's impact on HIF-1 stimulation, cardiac remodeling, and function after MI. Therefore, we analyzed nuclear HIF-1 expression, the mRNA and protein expression of key HIF-1 target genes (RT-PCR, Western blot), inflammatory cell infiltration (immunohistochemistry), and apoptosis (TUNEL staining) 7 days after MI. Additionally, we performed echocardiography in male and female C57BL/6 mice 28 days post-MI. Results: We found a substantial increase in nuclear HIF-1, associated with an upregulation of HIF-1α target genes like CXCL12/CXCR4/ACKR3 at the mRNA and protein levels. Roxadustat increased the proportion of myocardial reparative M2 CD206+ cells, suggesting beneficial alterations in immune cell migration and a trend towards reduced apoptosis. Echocardiography showed that roxadustat treatment significantly preserved ejection fraction and attenuated subsequent ventricular dilatation, thereby reducing adverse remodeling. Conclusions: Our findings suggest that roxadustat is a promising clinically approved treatment option to preserve myocardial function by attenuating adverse remodeling. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Correlation of 99mTc-DPD bone scintigraphy with histological amyloid load in patients with ATTR cardiac amyloidosis

Author

Ungericht, Maria, primary, Groaz, Valeria, additional, Messner, Moritz, additional, Schuetz, Thomas, additional, Brunelli, Luca, additional, Zaruba, Marc-Michael, additional, Lener, Daniela, additional, Stocker, Eva, additional, Bauer, Axel, additional, Kroiss, Alexander Stephan, additional, Mayr, Agnes, additional, Röcken, Christoph, additional, and Poelzl, Gerhard, additional

Published
2023
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10. Correlation of 99mTc-DPD bone scintigraphy with histological amyloid load in patients with ATTR cardiac amyloidosis.

Author

Ungericht, Maria, Groaz, Valeria, Messner, Moritz, Schuetz, Thomas, Brunelli, Luca, Zaruba, Marc-Michael, Lener, Daniela, Stocker, Eva, Bauer, Axel, Kroiss, Alexander Stephan, Mayr, Agnes, Röcken, Christoph, and Poelzl, Gerhard

Subjects
SINGLE-photon emission computed tomography, RADIONUCLIDE imaging, CARDIAC amyloidosis, AMYLOID, CARDIAC patients
Abstract

The significance of measuring 99mTc-labelled-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) in transthyretin (ATTR) cardiac amyloidosis has not been adequately studied. This single-centre observational study evaluated the correlation between 99mTc-DPD scintigraphy and histological amyloid load in endomyocardial biopsy (EMB). Twenty-eight patients with biopsy-proven ATTR amyloidosis and concomitantly available 99mTc-DPD scintigraphy were included. Visual Perugini scoring, and (semi-)quantitative analysis of cardiac 99mTc-DPD uptake by planar whole-body imaging and single photon emission computed tomography (SPECT/CT) using regions of interest (ROI) were performed. From this, heart-to-whole-body ratio (H/WB) and heart-to-contralateral-chest ratio (H/CL) were calculated. The histological amyloid load was quantified using two different staining methods. Increased cardiac tracer uptake was documented in all patients (planar: ROImean 129 ± 37 cps; SPECT/CT: ROImean 369 ± 142 cps). Histological amyloid load (19 ± 13%) significantly correlated with Perugini score (r = 0.69, p <.001) as well as with cardiac 99mTc-DPD uptake (planar: r = 0.64, p <.001; H/WB: r = 0.50, p =.014; SPECT/CT: r = 0.53, p =.008; H/CL: r = 0.43, p =.037) (results are shown for correlations with Congo Red-staining). In ATTR, cardiac 99mTc-DPD uptake significantly correlated with histological amyloid load in EMB. Further studies are needed to implement thresholds in cardiac 99mTc-DPD uptake measurements for risk stratification and guidance of therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy

Author

Ghadge, Santhosh Kumar, primary, Messner, Moritz, additional, Seiringer, Herbert, additional, Maurer, Thomas, additional, Staggl, Simon, additional, Zeller, Tanja, additional, Müller, Christian, additional, Börnigen, Daniela, additional, Weninger, Wolfgang J., additional, Geyer, Stefan H., additional, Sopper, Sieghart, additional, Krogsdam, Anne, additional, Pölzl, Gerhard, additional, Bauer, Axel, additional, and Zaruba, Marc-Michael, additional

Published
2021
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16. Heart failure from ATTRwt amyloid cardiomyopathy is associated with poor prognosis

Author

Kocher, Florian, primary, Kaser, Alex, additional, Escher, Felix, additional, Doerler, Jacob, additional, Zaruba, Marc‐Michael, additional, Messner, Moritz, additional, Mussner‐Seeber, Christine, additional, Mayr, Agnes, additional, Ulmer, Hanno, additional, Schneiderbauer‐Porod, Stephanie, additional, Ebner, Christian, additional, and Poelzl, Gerhard, additional

Published
2020
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24. Eosinophilic myocarditis complicated by permanent atrioventricular nodal block: a case report.

Author

Messner M, Mayr A, Zaruba MM, and Poelzl G

Abstract

Background: Eosinophilic myocarditis (EM) is a rare disease with different clinical pictures and disease courses. Little literature is available on the various courses of the disease., Case Summary: A previously healthy 44-year-old male patient presented with acute heart failure and developed complete atrioventricular (AV) block requiring pacing. Acute heart failure was managed with inotropic support, non-invasive ventilation, and implantation of a permanent AV-sequential pacemaker. Cardiac magnetic resonance imaging was suggestive of myocarditis and endomyocardial biopsy diagnosed EM histologically. Endomyocardial biopsy was essential for definite aetiologic assignment, thus dispelling initial reservations about immunosuppressive therapy. Final treatment strategy consisted of steroids and Azathioprine., Discussion: Endomyocardial biopsy is essential to establish diagnosis and targeted treatment in EM, which can rapidly lead to life-threatening conditions. Left ventricular function recovered within 2 weeks in response to immunosuppression and the patient was consistently well during follow-up. Despite the otherwise good response to immunosuppression, complete AV block continued over time., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2022
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