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This paper describes the design and the development of laser edge isolation (LEI) system for Si solar cells. It consists of a Q-switched 532 nm Nd:YVO4 laser source, an optical set up, a system motorized (X-Y) linear stages, a cell fixing system based on vacuum chuck, a camera to visualize the working zone and a He-Ne laser source for optical alignment. The command and control of the LEI system is ensured by a LabVIEW program and National Instruments (NI) devices. The designed system allows the positioning of the continuous isolation grooves very close to the edges leading to maximize the solar collection area and thus the efficiency. The proposed and developed approach consists to integrate a square shape unity file into the main program with a variable magnification factor, K. In order to demonstrate the operational and functional capabilities of the designed LEI system, series of experiments were conducted, scribing of continuous isolation grooves along four sides of multi crystalline Si solar cells with an area of 100 mm x 100 mm and a thickness of 320 µm to achieve electrical EI. It was shown that the grooves are well continuous and the measured values of continuous grooves lines width and depth are in the range of a typical groove dimensions. The voltage-current characteristics of the solar cells front side EI were analysed using a solar simulator. From our measurements result, we find that the best efficiency equal to 10.4 and the highest fill factor (FF) equal to 67 % ensure a satisfactory edge isolation (EI) of the solar cell. [ABSTRACT FROM AUTHOR]

This study investigates a sustainable coating method for modified expanded polystyrene (MEPS) beads to improve the thermal insulation of lightweight concrete intended for wall application. The method employed in this study is based on a novel coating technique that represents a significant advancement in modifying Expanded Polystyrene (EPS) beads for enhanced lightweight concrete. This study experimentally assessed the energy-saving capabilities of MEPS concrete in comparison to control groups of uncoated EPS beads and normal concrete by analysing early-stage temperature, thermal conductivity, specific heat capacity, heat flux, and thermal diffusivity. The thermal conductivity of MEPS concrete is approximately 40% lower than that of normal concrete, demonstrating its usefulness in enhancing insulation. The heat flux calculated for MEPS concrete is significantly reduced (approximately 35%), and it has a 20% lower specific heat capacity than ordinary concrete, indicating a reduction in energy transfer through the material and, thus, potential energy-efficiency benefits. Furthermore, the study discovered that all test objects have very low thermal diffusivity values (less than 0.5 × 10−6 m2/s), indicating a slower heat transport through the material. The sustainable coating method utilized fly ash-enhanced thermal efficiency and employed recycled materials, hence decreasing the environmental impact. MEPS concrete provides a practical option for creating sustainable and comfortable buildings through the promotion of energy-efficient wall construction. Concrete incorporating coated EPS can be a viable option for constructing walls where there is a need to balance structural integrity and adequate insulation.

Objectives Several studies have shown that cholecalciferol supplementation (25OHD-S) in chronic kidney disease (CKD) improves kidney injury by reducing fibrosis-related vascular calcification and declining apoptosis-linked nephron damage.Methods The oral 25OHD-S was evaluated in 60,000 IU/month/36 weeks versus in 2000 IU/d/24 weeks in CKD Stage 3 with serum 25OHD level < 20 ng/mL. The study was undertaken on 156 black subjects and 150 white subjects Southern Sahara (SS). All biomarkers of cardiometabolic (CMet) and cardiorenal (CRenal) syndrome, Renin-angiotensin-aldosterone system (RAAS) profile, secondary hyperparathyroidism (SHPT), N-terminal pro B-type natriuretic peptide (NT-proBNP), Troponin T (cTnT) and atherogenicity risk were assessed by biochemical methods. Estimate glomerular filtration rate (eGFR) by chronic CKD-EPI equation formula. Total serum vitamin D by liquid chromatography-tandem mass spectrometry (MS).Results Vitamin D deficiency alters in the same manner CMet, CRenal, and others biomarkers in both groups SS; however, these disorders are more acute in blacks compared to whites SS. Oral 25OHD-S a highlighted improvement of eGFR drop, SHPT decrease, decline proteinuria, and cardiac failure risk (NT-proBNP and cTnT) attenuation. Concomitantly, 25OHD-S normalizes Renin, Aldosterone, and Angiotensin System (RAAS) activity. Nevertheless, homocysteine and Lp (a) do not modulate by 25OHD-S.Conclusions The oral vitamin D3 supplementation, according the dose, and the treatment duration does not like in black-skinned people versus to white-skinned inhabitants, while the 02 groups are native to the same Saharan environment. It emerge that a high intermittent dose through an extensive supplementation (60,000 IU/36 weeks) was more effective in black subjects. At opposite, a lower dose during a short period supplementation is sufficient (2000 IU/24 weeks) in white subjects.

This paper is concerned with investigating the plastic behavior of gap K-joints of truss girders, made from thin-walled rectangular hollow section members. The novelty of the method is that it offers a rigorous numerical model that may be generalized to cover similar joints with different parameters to the one covered in this study. An experimental study was carried out on a full-scale girder under concentrated load on two central nodes. A numerical analysis was carried out using ABAQUS to investigate the behavior of this type of joints and comparison is made with the experimental results. The study aims to examine and define the analytical model for this type of joints. The results obtained show that sections with chord/brace thickness ratio (t0/t1)=1 exhibit a different behavior compared to sections with (t0/t1)>1. From this study, it was possible to obtain the modes of failure of such sections followed by a comparative study on the determination of the joint capacity using Eurocode 3 and CIDECT

The high kaolinite content of metakaolin makes it valuable to other industries, thereby affecting its availability and affordability for the production of limestone calcined clay cement (LC3). This work presents a study on the potential utilization of low-grade clay in place of pure metakaolin in the preparation of LC3 for mortar formulations. CEM I was partially substituted with calcined clay and limestone by 20, 30, 40, and 50 wt.%. The weight ratio of calcined clay and limestone was maintained at 2:1 for all mixes and the water-to-binder ratio was 0.48. X-ray diffraction (XRD), thermogravimetric analysis (TGA), and isothermal conduction calorimetry were used to study the hydration process and products after 28 days. Mechanical and durability assessments of the LC3 mortar specimens were conducted. LC3 specimens (marked LC20%, LC30%, LC40%, and LC50%) trailed the control sample by 1.2%, 4%, 9.8%, and 18%, respectively, at 28 days and 1.6%, 2.3%, 3.6%, and 5.5%, respectively, at 91 days. The optimum replacement of OPC clinker, calcined clay, and limestone was 20% (LC20%).

This research focuses on the optimization of formulation, characterization, and damage analysis of plant fiber-reinforced polyester resin composites (jute and date palm). To better understand the characteristics and mechanical behavior of these materials, this study investigates the influence of resin content and plant fibers on the physico-mechanical behavior of the resin composites. Resinous composites consisting of polyester resin and raw earth were studied using a novel formulation based on an empirical method that follows the principle of earth saturation with polyester resin. Saturation was achieved with a 28% content of polyester resin, which appeared to be an optimal blend for the earth–resin composite. Plant fibers were randomly incorporated as reinforcement in the composites at various percentages (1%, 2%, and 3%) and lengths (0.5 cm, 1 cm, and 1.5 cm). Mechanical tests including bending, compression, and indentation were conducted to evaluate the mechanical properties of the composites. Analysis of fracture morphology revealed that the deformation and rupture mechanisms in bending, compression, and indentation of these composites differ from those of traditional concrete and cement mortar. The obtained results indicate that the composites exhibit acceptable performance and could be favorably employed in the rehabilitation of historic buildings.

At ambient temperature, concrete exhibits excellent mechanical properties. However, understanding the behavior of concrete under high-temperature conditions is crucial, especially for civil engineering applications during fire incidents. The growing use of plastic-based products has led to a significant increase in polymer waste, posing environmental challenges. The valorization of this plastic waste in the form of fibers presents both economic and environmental advantages. This study focuses on the study of the behavior of sand concrete incorporating polyethylene terephthalate (PET) fibers with percentages of 1% and 2% at high temperatures (100, 300, 500 and 700 °C). Specimens are tested for residual mass loss, residual compressive and tensile strength. A complementary analysis of SEM makes it possible to confirm and better clarify the morphology of the concretes of sand before and after the rise in temperature. The results obtained from this study indicate that the residual resistance is reduced with the rise in temperature for all the concretes studied, except in the temperature range of 300 °C, in which a slight improvement in resistance is noticed. The incorporation of PET fibers in the test concretes does not enhance their residual behavior significantly. However, it does serve as an effective solution by reducing the susceptibility to spalling, by preventing cracking and by fulfilling a similar role to that of polypropylene fibers.

The availability of some supplementary cementitious materials, especially fly ash, is of imminent concern in Europe due to the projected closure of several coal-fired power generation plants. Pure kaolinitic clays, which arguably have the potential to replace fly ash, are also scarce and expensive due to their use in other industrial applications. This paper examines the potential utilisation of low-grade kaolinitic clays for construction purposes. The clay sample was heat-treated at a temperature of 800 °C and evenly blended with Portland cement in substitutions of 10–30% by weight. The physical, chemical, mineralogical and mechanical characteristics of the blended calcined clay cement were determined. The Frattini test proved the pozzolanic potential of the calcined impure clay, as a plot of its CaO and OH− was found below the lime solubility curve. The 28 days compressive strengths trailed the reference cement by 5.1%, 12.3% and 21.7%, respectively, at all replacement levels. The optimum replacement level between the three blends was found to be 20 wt.%.

The 25-hydroxyvitamin D3 (25OHD3) deficiency in chronic kidney disease (CKD) is associated with immune system dysfunction (pro-inflammatory cytokines storm) through macrophages renal infiltration, oxidative stress (OxS) damage and athero-thromboembolic risk. Conversely, cholecalciferol supplementation (25OHD-S) prevents kidney fibrosis by inhibition of vascular calcification and nephrotic apoptosis (nephrons reduction). The objective of this study was to investigate the pleiotropic effects of 25OHD-S on immunomodulation, antioxidant status and in protecting against thromboembolic events in deficiency CKD Black and White individuals living in the Southern Sahara (SS). The oral 25OHD-S was evaluated in 60,000 IU/month/36 weeks versus in 2000 IU/day/24 weeks in Black (n = 156) and White (n = 150). Total serum vitamin D was determined by liquid chromatography-tandem mass spectrometry. All biomarkers of pro-inflammatory cytokines (PIC) were assessed by ELISA tests. OxS markers were assessed by Randox kits. Homocysteine and lipoproteine (a) were evaluated by biochemical methods as biomarkers of atherothromboembolic risk. All statistical analyses were performed with Student’s t-test and one-way ANOVA. The Pearson test was used to calculate the correlation coefficient. The means will be significantly different at a level of p value < 0.05. Multiple logistic regressions were performed using Epi-info and Statview software. Vitamin D deficiency alters the PIC profile, OxS damage and atherothrombogenic biomarkers in both SS groups in the same manner; however, these disorders are more acute in Black compared to White SS individuals. The results showed that the serum 25OHD3 concentrations became normal (>75 nmol/L or >30 ng/mL) in the two groups. We have shown that the dose and duration of 25OHD-S treatment are not similar in Black SS residents compared to White SS subjects, whilst the same inhabit the south Sahara environment. It appears that a high dose intermittent over a long period (D60: 36 weeks) was more efficient in Black people; while a lower dose for a short time is sufficient (D2: 24 weeks) in their White counterparts. The oral 25OHD-S attenuates PIC overproduction and OxS damage, but does not reduce athero-thromboembolic risk, particularly in Black SS residents.

Serviceability behavior of Normal Strength Concrete (NSC) and High Strength Concrete (HSC) T-beams was experimentally evaluated. The crack pattern was observed, the effect of flange dimensions (breadth and thickness) on the crack pattern and load-deflection response was evaluated experimentally for 10 beams comprising the two studied groups, NSC and HSC T-beams. The short-term deflections were measured experimentally and predicted empirically under mid-span concentrated loading. It was found that increasing the flange width and thickness resulted in higher loads and lower deflections under service loads to a different extent. Prior to failure, the increment in the maximum loads was up to 22% while the deflection reduced by 31% for NSC and 23% for HSC beams. The available equations for determining the effective moment of inertia (Ie) were reviewed and used in predicting the Ie of the cracked beam. The results were compared with the experimental values (Iexp). The Ie showed a noticeable difference, especially for the HSC T-beams. New equations were proposed in which the tensile reinforcement ratio was considered. Compared with the other available equations, the proposed equations demonstrated a better agreement and repeatability of predicting experimental results studied herein. In addition, the proposed equations were used to predict the Ie for experimentally tested T-beams available in the literature. The proposed models showed a high degree of accuracy.

Web caching has been the solution of choice to web latency problems. The efficiency of a Web cache is strongly affected by the replacement algorithm used to decide which objects to evict once the cache is saturated. Numerous web cache replacement algorithms have appeared in the literature. Despite their diversity, a large number of them belong to a class known as stack-based algorithms. These algorithms are evaluated mainly via trace-driven simulation. The very few analytical models reported in the literature were targeted at one particular replacement algorithm, namely least recently used (LRU) or least frequently used (LFU). Further they provide a formula for the evaluation of the Hit Ratio only. The main contribution of this paper is an analytical model for the performance evaluation of any stack-based web cache replacement algorithm. The model provides formulae for the prediction of the object Hit Ratio, the byte Hit Ratio, and the delay saving ratio. The model is validated against extensive discrete event trace-driven simulations of the three popular stack-based algorithms, LRU, LFU, and SIZE, using NLANR and DEC traces. Results show that the analytical model achieves very good accuracy. The mean error deviation between analytical and simulation results is at most 6% for LRU, 6% for the LFU, and 10% for the SIZE stack-based algorithms. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Background: Despite its ecological importance, the study of Algerian alder forests has been largely neglected, even though they represent the largest ones of their kind in North Africa. Moreover, few measures have been taken towards the protection of these ecosystems. Questions: How many species are present in the Algerian alder forests? What is the effect of soil properties on species richness and diversity of inventoried plants? Is its spatial patterns a result of soil variables variation? Studied species: Polypodiopsida, Gymnospermae, and Angiospermae. Study site and dates: El-Kala Biosphere Reserve (KBR), El-Tarf province, northeastern Algeria, from January 2016 to February 2017. Methods: Twenty-eight localities were sampled using the relevé method. Soil samples were taken from three points at each site. The relationship between species richness and soil factors was statistically evaluated using multiple linear regression and multivariate statistical analysis. Results: The inventory showed a total of 352 species that belong to 236 genera and 89 families. According to NMDS results, black alder forests were classified into two groups (marshy and the hilly, and the fluvial forests), in relation to plant species richness. No linear relationships between species richness and soil parameters were observed, except for OM (P = 0.013). Conclusion: The present study allowed us to perform an inventory of plant species present in alder forests and to understand its distribution among different habitat types, as well as those factors that affect its zonation. For this ecosystem, our study revealed that vegetation diversity is related to the variation of soil variables.

Being interested in multiple office-holding as “holy secularism" of local power means wondering about an old political practice introduced by the Revolution of 1789 and anchored in our institutions since the Third Republic. This regime, established by the constitutional laws of 1875, has the merit for the first time to connect by legalizing him, multiple office-holding and the accumulation of allowances. We shall limit ourselves to the French local political power through one of its major symbols, the multiple office-holding of the representatives of regions with a measure of autonomy and\or EPCI with their own tax system. Local power, as any political power, infringes on the domain of the sacred and feeds on religious references (faiths, myths, rites and symbols). The analysis of the normative reach of the organic and ordinary laws of 2014 as well as their symbolic impact seems to show that the legislator did not fundamentally question the principle of multiple office-holding as a strong symbol of local power.

Our aim in the present study was to examine the effect of listening to self-selected music during soccer warm-ups in morning and afternoon sessions on repeated-sprint performances of elite soccer players. Twenty elite academy male soccer players performed a repeated-sprint ability (RSA) test in the morning (i.e., 07:00 hours) and in the afternoon (i.e., 17:00 hours), with or without listening to music during the warm-up period. The RSA test consisted of six 40-meter sprints with 180° direction changes interspersed with a 20-second passive recovery period. Ratings of perceived exertion (RPE) were obtained at the end of the warm-up period and immediately after the RSA test. Results showed that listening to music during warming-up had no significant effect on these selected performance measures (i.e., mean sprint time, best sprint time, RSA decrement), regardless of whether performances were in the morning or the afternoon. Moreover, players reported higher post-warm-up RPE scores in the music listening condition than in the no-music listening condition, only in the afternoon session. Furthermore, RPE scores measured after the RSA test were higher in the no-music listening condition compared to the music listening condition, only in the morning session. Thus, the use of music during warming-up in elite soccer players appears to be an individual athlete's choice but not a reliable means of enhancing performance., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

No consensus has been reached regarding the association beween the -308A/G single nucleotide polymorphism (SNP) in the tumor necrosis factor-α gene (TNFA) and kidney allograft rejection (KAR). Our retrospective case-control study aimed to assess the association of the SNP with KAR in Algerian patients who underwent kidney transplantation. The study enrolled 313 Algerian patients: 58 kidney-transplant recipients without rejection events (PWoR); 58 kidney-transplant recipients with at least one rejection event, with or without graft loss (PWR); and 197 healthy individuals (HI). The TNFA -308A/G SNP was genotyped using a real-time polymerase chain reaction. The results demonstrated that, the frequencies of TNFA -308A allele and AA genotype were higher in the PWR than in the HI groups (p = 0.001, OR = 2.26, CI = 1.33-3.77 and p = 0.0004, OR = 5.53, CI-1.89-16.6, respectively). Furthermore, the frequencies were higher among the PWR than among the PWoR groups (p = 0.001, OR = 3.29, CI = 1.56-7.21 and p = 0.0006, OR = 28.26, CI = 1.62-493.2, respectively), particularly among PWR patients with de novo anti-human leukocyte antigens (HLA) antibodies (PG-a-HLA-Ab). However, the frequency of TNFA -308G allele was lower in the PWR group than in the PWoR group (p = 0.001, OR = 0.3, CI = 0.1-0.64) and the HI group (p = 0.001, OR = 0.44, CI = 0.27-0.44). Our results suggest an association of the TNFA -308A/G alleles with KAR in Algerian patients who underwent kidney transplantation. Carriers of TNFA -308A allele who have PG-a-HLA-Ab might have a higher risk, whereas TNFA -308G allele carriers could have a lower risk of KAR. Thus, therapeutic strategies can be adapted to minimize KAR risk in patients who have a genetic proclivity for increased pro-inflammatory TNF-α activity., Competing Interests: Declaration of Competing Interest None., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Background: Analyzing the unstructured textual data contained in electronic health records (EHRs) has always been a challenging task. Word embedding methods have become an essential foundation for neural network-based approaches in natural language processing (NLP), to learn dense and low-dimensional word representations from large unlabeled corpora that capture the implicit semantics of words. Models like Word2Vec, GloVe or FastText have been broadly applied and reviewed in the bioinformatics and healthcare fields, most often to embed clinical notes or activity and diagnostic codes. Visualization of the learned embeddings has been used in a subset of these works, whether for exploratory or evaluation purposes. However, visualization practices tend to be heterogeneous, and lack overall guidelines., Objective: This scoping review aims to describe the methods and strategies used to visualize medical concepts represented using word embedding methods. We aim to understand the objectives of the visualizations and their limits., Methods: This scoping review summarizes different methods used to visualize word embeddings in healthcare. We followed the methodology proposed by Arksey and O'Malley (Int J Soc Res Methodol 8:19-32, 2005) and by Levac et al. (Implement Sci 5:69, 2010) to better analyze the data and provide a synthesis of the literature on the matter., Results: We first obtained 471 unique articles from a search conducted in PubMed, MedRxiv and arXiv databases. 30 of these were effectively reviewed, based on our inclusion and exclusion criteria. 23 articles were excluded in the full review stage, resulting in the analysis of 7 papers that fully correspond to our inclusion criteria. Included papers pursued a variety of objectives and used distinct methods to evaluate their embeddings and to visualize them. Visualization also served heterogeneous purposes, being alternatively used as a way to explore the embeddings, to evaluate them or to merely illustrate properties otherwise formally assessed., Conclusions: Visualization helps to explore embedding results (further dimensionality reduction, synthetic representation). However, it does not exhaust the information conveyed by the embeddings nor constitute a self-sustaining evaluation method of their pertinence., (© 2022. The Author(s).)

Recurrent cystitis (RC) has rarely been studied; its management varies and research on a holistic approach of these patients is scarce. We attempted to characterize patients suffering from RC and investigated their current care pathways, aiming to offer customized and autonomous management. In this paper, we present a descriptive, single-center, cross-sectional study of women presenting with RC at an infectious disease (ID) clinic. A questionnaire was developed and was completed by ID physicians during patient visits. From October 2016 to January 2019, 202 women were included (mean age 59 years). Sexual intercourse, stress and diarrhoea/digestive symptoms were reported as trigger factors by 35%, 34% and 19% of patients, respectively. A majority (54%) were at risk for complications and were those more exposed to inappropriate antibiotic prescriptions. In total, 56% of women suffered from more than 10 episodes/year and 48% suffered from relapses, mainly due to E. coli . Genitourinary syndrome of menopause (GSM) was a frequent complaint (74.5% of women). Fluoroquinolones and 3rd generation cephalosporins were prescribed in 38% and 30% of women, respectively. Most women wished for non-antimicrobial approaches and autonomy. Patients require comprehensive, tailored care in order to benefit from a broader range of treatment options in compliance with recommendations.

At the end of 2019, the infectious coronavirus disease (COVID-19) was reported for the first time in Wuhan, and, since then, it has become a public health issue in China and even worldwide. This pandemic has devastating effects on societies and economies around the world, and poor countries and continents are likely to face particularly serious and long-lasting damage, which could lead to large epidemic outbreaks because of the lack of financial and health resources. The increasing number of COVID-19 tests gives more information about the epidemic spread, and this can help contain the spread to avoid more infection. As COVID-19 keeps spreading, medical products, especially those needed to perform blood tests, will become scarce as a result of the high demand and insufficient supply and logistical means. However, technological tests based on deep learning techniques and medical images could be useful in fighting this pandemic. In this perspective, we propose a COVID-19 disease diagnosis (CDD) tool that implements a deep learning technique to provide automatic symptoms checking and COVID-19 detection. Our CDD scheme implements two main steps. First, the patient's symptoms are checked, and the infection probability is predicted. Then, based on the infection probability, the patient's lungs will be diagnosed by an automatic analysis of X-ray or computerized tomography (CT) images, and the presence of the infection will be accordingly confirmed or not. The numerical results prove the efficiency of the proposed scheme by achieving an accuracy value over 90% compared with the other schemes., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2022 Seifeddine Messaoud et al.)

Multimedia IoT (M-IoT) is an emerging type of Internet of things (IoT) relaying multimedia data (images, videos, audio and speech, etc.). The rapid growth of M-IoT devices enables the creation of a massive volume of multimedia data with different characteristics and requirements. With the development of artificial intelligence (AI), AI-based multimedia IoT systems have been recently designed and deployed for various video-based services for contemporary daily life, like video surveillance with high definition (HD) and ultra-high definition (UHD) and mobile multimedia streaming. These new services need higher video quality in order to meet the quality of experience (QoE) required by the users. Versatile video coding (VVC) is the new video coding standard that achieves significant coding efficiency over its predecessor high-efficiency video coding (HEVC). Moreover, VVC can achieve up to 30% BD rate savings compared to HEVC. Inspired by the rapid advancements in deep learning, we propose in this paper a wide-activated squeeze-and-excitation deep convolutional neural network (WSE-DCNN) technique-based video quality enhancement for VVC. Therefore, we replace the conventional in-loop filtering in VVC by the proposed WSE-DCNN model that eliminates the compression artifacts in order to improve visual quality and hence increase the end user QoE. The obtained results prove that the proposed in-loop filtering technique achieves - 2.85 %, - 8.89 %, and - 10.05 % BD rate reduction for luma and both chroma components under random access configuration. Compared to the traditional CNN-based filtering approaches, the proposed WSE-DCNN-based in-loop filtering framework achieves efficient performance in terms of RD cost., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021.)

With the rapid advancement in many multimedia applications, such as video gaming, computer vision applications, and video streaming and surveillance, video quality remains an open challenge. Despite the existence of the standardized video quality as well as high definition (HD) and ultrahigh definition (UHD), enhancing the quality for the video compression standard will improve the video streaming resolution and satisfy end user's quality of service (QoS). Versatile video coding (VVC) is the latest video coding standard that achieves significant coding efficiency. VVC will help spread high-quality video services and emerging applications, such as high dynamic range (HDR), high frame rate (HFR), and omnidirectional 360-degree multimedia compared to its predecessor high efficiency video coding (HEVC). Given its valuable results, the emerging field of deep learning is attracting the attention of scientists and prompts them to solve many contributions. In this study, we investigate the deep learning efficiency to the new VVC standard in order to improve video quality. However, in this work, we propose a wide-activated squeeze-and-excitation deep convolutional neural network (WSE-DCNN) technique-based video quality enhancement for VVC. Thus, the VVC conventional in-loop filtering will be replaced by the suggested WSE-DCNN technique that is expected to eliminate the compression artifacts in order to improve visual quality. Numerical results demonstrate the efficacy of the proposed model achieving approximately -2.85%, -8.89%, and -10.05% BD-rate reduction of the luma ( Y ) and both chroma ( U , V ) components, respectively, under random access profile., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Soulef Bouaafia et al.)

Objectives We investigated the quality of life (QOL) in parents of children with late treated phenylketonuria (PKU) and its associated factors. Methods We conducted a cross sectional study in the reference center of inherited metabolic disease in Tunisia. We used the Tunisian version of the 36-item short-form health survey questionnaire (SF-36). We compared variables in the groups with and without impaired QOL and the SF-36 scores between subgroups of parents and children and between our sample and the Tunisian general population based on published data. We looked for associations between SF-36 scores and quantitative variables. Linear regression and logistic binary regression were used for multivariate analysis. Results Sixty-five parents from 42 families participated. QOL was impaired in 61% of them. The mean SF-36 score was 55.3 ± 25.07. The physical component sub-score was higher than that reported in the Tunisian general population (63.66 ± 27.77 vs. 50.11 ± 8.53; p<0.001). The mental component sub-score was comparable to that reported in the Tunisian general population (46.99 ± 25.94 vs. 47.96 ± 9.82; p=0.830). Gender (mothers) (p=0.008), low monthly income (p = 0.027), low education (p=0.011), and autism in PKU children (p = 0.001) were associated with impaired QOL. Conclusions We identified at risk parents for altered quality of life among parents of PKU children. Our findings were used to develop a psychological and social support strategy for at-risk parents and to promote the implementation of newborn screening of this treatable disease in our low-income country.

Background: The outcome of Kawasaki disease (KD) depends on cardiovascular complications (CVCs)., Objectives: This study aimed to explore diagnostic features and CVCs in Tunisian patients with KD., Methods: In total, 33 Tunisian patients (age, 2.9 ± 2.2 years) fulfilling the diagnosis criteria of KD, were retrospectively reviewed. Nonparametric tests were used to compare the two groups with regards to coronary complications (CCs)., Results: Diagnosis of KD was established at day 11 ± 5.1 from the beginning of the fever. Apyrexia was obtained in an average of 29 h after completion of intravenous immunoglobulin. CVCs were identified in 52% of cases: CC in 15 patients (giant aneurysm >8 mm in five patients) and non-CCs in 6 patients (severe in three patients). CCs were more frequently associated with the male sex (p = 0.037), fever lasting >8 days (p = 0.028) and longer time to apyrexia (p = 0.031)., Conclusion: In Tunisia, better knowledge and monitoring of KD are warranted., (© The Author(s) [2018]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Background: Performing genetic counseling is one of the tasks of every paediatrician. This assumes prior training during the residency., Aim: To assess the impact of role-play (RP) for training of paediatric residents in genetic counseling and participants' perception., Methods: Repetitive cross-sectional evaluation study. During two RP sessions, two residents played the role of the parents of a patient with cystic fibrosis, and another the role of the doctor. Residents had an evaluation by standardized patient exercises immediately before and after the session. Test scores were compared by the Wilcoxon rank test for associated samples. A satisfaction questionnaire was completed by the participants anonymously., Results: Post-test scores were better than pre-test scores overall (p = 0.002) and for items in the cognitive domain (p = 0.002). Of the 12 participants, only one had had previous training in genetic counseling. All participants were satisfied with the learning and felt that it would change the way they practice. All participants thought they could do genetic counseling autonomously, but nine of them wanted to have other RP sessions on the same theme. Only one participant found the session stressful and all wanted to multiply this type of sessions for other learning., Conclusion: RP is an effective and well-accepted means for genetic counseling training. It should be integrated with paediatric resident training.

Background: Our aim was to describe the natural history of neuromuscular involvement (NMI) in glycogen storage disease type III (GSDIII)., Methods: We conducted a longitudinal study of 50 Tunisian patients, 9.87 years old in average., Results: NMI was diagnosed at an average age of 2.66 years and was clinically overt in 85% of patients. Patients with clinical features were older ( p  = 0.001). Complaints were dominated by exercise intolerance (80%), noticed at 5.33 years in average. Physical signs, observed at 6.75 years in average, were dominated by muscle weakness (62%). Functional impairment was observed in 64% of patients, without any link with age ( p  = 0.255). Among 33 patients, 7 improved. Creatine kinase (CK) and aspartate aminotransferase (AST) levels were higher with age.Electrophysiological abnormalities, diagnosed in average at 6.5 years, were more frequent after the first decade ( p  = 0.0005). Myogenic pattern was predominant (42%). Nerve conduction velocities were slow in two patients. Lower caloric intake was associated with more frequent clinical and electrophysiological features. Higher protein intake was related to fewer complaints and physical anomalies., Conclusion: Neuromuscular investigation is warranted even in asymptomatic patients, as early as the diagnosis of GSDIII is suspected. Muscle involvement can be disabling even in children. Favorable evolution is possible in case of optimal diet., Competing Interests: Disclosure The authors report no conflicts of interest in this work., (Georg Thieme Verlag KG Stuttgart · New York.)

Background Glycogen storage disease type III (GSDIII), due to a deficiency of glycogen debrancher enzyme (GDE), is particularly frequent in Tunisia. Phenotypic particularities of Tunisian patients remain unknown. Our aim was to study complications of GSDIII in a Tunisian population and to explore factors interfering with its course. Methods A retrospective longitudinal study was conducted over 30 years (1986-2016) in the referral metabolic center in Tunisia. Results Fifty GSDIII patients (26 boys), followed for an average 6.75 years, were enrolled. At the last evaluation, the median age was 9.87 years and 24% of patients reached adulthood. Short stature persisted in eight patients and obesity in 19 patients. Lower frequency of hypertriglyceridemia (HTG) was associated with older patients (p<0.0001), higher protein diet (p=0.068) and lower caloric intake (p=0.025). Hepatic complications were rare. Cardiac involvement (CI) was frequent (91%) and occurred early at a median age of 2.6 years. Severe cardiomyopathy (50%) was related to lower doses of uncooked cornstarch (p=0.02). Neuromuscular involvement (NMI) was constant, leading to a functional discomfort in 64% of cases and was disabling in 34% of cases. Severe forms were related to lower caloric (p=0.005) and protein intake (p<0.015). Conclusions A low caloric, protein and uncooked cornstarch intake is associated with a more severe outcome in GSDIII Tunisian patients. Neuromuscular and CIs were particularly precocious and severe, even in childhood. Genetic and epigenetic factors deserve to be explored.

Using modeling and simulation, we quantify the influence of spatiotemporal dynamics on the accuracy of data obtained from sensors placed in microscaled reaction volumes. The model refers to cellular reaction (i.e. proton extrusion and oxygen consumption) in complex, buffering solutions. Whole cells or viable tissues cultured in such devices are monitored in real time with integrated sensors for pH and dissolved oxygen. A 3D finite element model of diffusion and metabolic reaction was set up. With respect to pH, the effect of buffering species on proton diffusion is analysed in detail. To account for the delayed time response of real sensors, the sensor impulse response time was implemented by linear convolution. A validation of the model has been achieved by an electrochemical approach. The model reveals significant deviations of measured pH and O2, and values of these parameters actually occurring at different sites of the cell culture volume. It is applicable to any setting of (bio-) sensors involving reaction and diffusion of dissolved gases and particularly H(+) ions in buffered solutions.

Most often epidemiologic studies of violence during adolescence focus on aspects related to the perpetrator. The adolescent victims of violence are certainly at least as numerous, but too little is known about them. Our aim was to estimate the extent of this social phenomenon and to identify its various forms, through a descriptive, cross-sectional study of a sample of 685 teenagers (409 girls and 276 boys) from six public high schools in Sousse in 1999. A school physician conducted structured interviews to collect the data, recorded in compliance with the ethical rules of confidentiality and anonymity. The results indicate that 36.9% of the adolescents (54% of the boys and 24% of the girls) reported experiencing violence. Within the group of victims, physical violence was reported by 78% of the boys and 63% of the girls, verbal violence by 51% and 63%, respectively. We conclude that experiencing violence is far from uncommon and that it causes acute suffering for youngsters during an important phase of their emotional development and exposes them to the risk of becoming violent as adults. School medical staff can play a crucial role in the prevention and the management of this mistreatment., (Copyright John Libbey Eurotext 2003)