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1. Fifth Annual Summer Research Summit on Health Equity Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on May 17, 2022

Author

Aaditya Arun, Abhijit Rao, Abigail Hecht, Aaron Garcia, Abiodun Oluyomi, Aaron Lapidus, Achilia Morrow, Adaeze Eze, Adedoyin Adesina, Ajeesh Sunny, Aleah Booker, Alejandra Duque, Aleksandr Tichter, Alexandra Alvarenga, Alexandra Fincher, Alexandra Regens, Alexandria Heinze, Alexis Batiste, Alice King, Alicia Bao, Alison Zill, Aliza Wong, Allison Teng, Alqassem Hakami, Amanda Barczyk, Amari Johnson, Amy Engler, Analisia Stewart, Anam Ahmed, Andrea Wallace, Andrew Anderson, Andrew Wapner, Angela Park, Anirudh Gadicherla, Anita Ramsetty, Anna Volerman, Anthony Duruewuru, Arkene Levy, Arlette Chavez, Armando Martinez, Ashley Alford, Ashly Paul, Asia Payne, Audrey Huang, Avery Allen, Ayleen Hernandez, Beau Meyer, Brian Downer, Brian Reed, Brianna Wapples, Cara Gomez, Carli O'Neal, Cassandra Pasadyn, Cate Campisi, Charles Hyman, Charleta Guillory, Chasity O’Malley, Chelsea Godfrey, Chethan Rao, Chris Amos, Chris Draft, Christen Jarshaw, Christian Shannon, Christina Kuruvilla, Christo Manikkuttiyil, Christopher Moriates, Claire Bollinger, Connor Vaculik, Courtney Jacobs, Crystal Casado, Cynthia Jumper, D. Wood, Dana Clark, Daniel Griffin, Daniel Millian, Danielle Gonzales, Danya Aljafari, Daryle Pickens, David Danesh, David Hsiou, David Karngba, Deepa Dongarwar, Demetria Smith-Graziani, Denise Iheanachor, Derek Yan, Devika Jaishankar, Elizabeth Keating, Elizabeth Onugha, Ellen Fremion, Ellie Edwards, Emelia Watts, Emily Anderson, Emily Powell, Emily Zientek, Emmanuel Achilike, Eric Rademacher, Erik Malmberg, Eugene Manley, Eunique Williams, Faisal Alqahtani, Farrah Jacquez, Farzanna Haffizulla, Felicia Rosiji, Felicia Skelton, Fyona Okundia, Gabriela Tantillo, Gabriela Garcia, Gabrielle Jacquet, Gabrielle Young, Gal Barbut, Genevra Murray, George Idehen, Grayson Jackson, Grey Loyd, Gualberto Munoz, Haeyeon Hong, Haley Ponce, Hamisu Salihu, Hammad Khalid, Hamza Shamim, Hanna Fanous, Heli Patel, Homa Amini, Hyacinth Mason, Hye Choi, Ian Peake, Ibrahim Omer, Ida Orengo, Ifeoma Ezenwabachili, Imelda Vetter, Israa Malli, Ivan Ponce, Jacob Moran, Jad Zeitouni, Jaideep Kapur, Jake Lynn, Jasmine Lemmons, Jay Ulysses, Jean Raphael, Jeff Robison, Jenna Jenna Zamil, Jennifer Onwukwe, Jensen Gary, Jessica McGraw-Heinrich, Jessica Lin, Jesus Vallejo, Jodie Holodak, John Davis, John Jawiche, John Miggins, Khan Mohammad, Kiara Olmeda, Kimberly Hammersmith, Kirsten Wheeler, Kristen Staggers, Kristian Jones, Kristina Hulten, Kylie Hagerdon, Laiba Asif, Lainie Mabe, Larissa Grigoryan, Laura Rosen, Laurel Chen, Lauren Gambill, Lauren Oliver, Lee Poythress, Leonard Wang, Lindsey Yates, Lisa Noll, Lon Pang, Lori Crosby, Love Nzeadu, Luis Lang, Luis Rustveld, Luke Gilman, Luke Nordstrom, Lydia Meece, Maija Holsti, Maisha Standifer, Marcus Moses, Margaux Amara, Maria Hernandez, Maria Macias, Maria Vigil-Mallette, Mariah Mills, Mariana Baroni, Maricarmen Marroquin, Mario Witt, Marissa Goodwin, Martha Diaz, Mary Fang, Maryam Shafaee, Matthew Morones, May Sudhinaraset, Meena Kannan, Melissa Bondy, Melissa Dunn, Melissa Suter, Meselle Jeff-Eke, Michael Hole, Michael Igwe, Michael Zhu, Michelle Colarelli, Michelle Debbink, Miles Farr, Mohamad Halawi, Monica Kowalczy, Monica Mitchell, Morgan Lee, Morgan Williams, Morhaf Achkar, Nabeeha Engineer, Nada Naaman, Nagireddy Putluri, Nalini Ram, Nancy Osazuwa, Natalie Guerrero, Natalie Tedford, Nathalie Jetté, Nathaniel Giles, Navya Kumar, Nicholas Peoples, Nital Appelbaum, Norman Farr, Oriana Reyes, Pablo de la Vega, Pablo Coello, Parker Kirby, Parth Malaviya, Patrick Hardigan, Paul Hershberger, Paulina Powell, Perry Smith, Praneet Paidisetty, Priyanka Ranchod, Rachel Deer, Rachel Johnston, Radha Nune, Rashmi Koul, Raymond Kitziger, Reagan Collins, Rebecca Woofter, Reginald Toussant, Ria Brown, Rider Calhoun, Riley Martinez, Rojelio Mejia, Romy Pena, Ryan Shepherd, Sajani Patel, Samagra Jain, Samiksha Prasad, Sarah Bell, Sarah Durbin, Sarah Heady, Sarah Pajka, Sarah Peiffer, Sarah Raines, Sarah Taha, Scott Rosenfeld, Shangyi Fu, Sheldon Kaplan, Shellie Wolf, Shixia Huang, Siya Khanna, Siyue Wang, Sofia Gereta, Soham Snih, Spencer Krane, Stacey Gomes, Stacey Rose, Stacy Pierson, Stephanie Camey, Stephanie Ivy, Stephanie Loo, Steven Mehl, Sumiko Maristany, Sundeep Keswani, Sunny Nakae, Susanna Cohen, Sylvia Adu-Gyamfi, Tamara Ortiz-Perez, Tania Alfaro, Tarrance Williams, Teresia O’Connor, Theresa Byrd, Thomas Agostini, Thomas Bini, Thomas Medrano, Tiffany Anaebere, Tim Lee, Timothy Crawford, Tina Brock, Ton La, Unoma Akamagwuna, Upal Roy, US Pediatric Multicenter Pneumococcal Surveillance Group, Vidhyasai Annem, Vijay Rajput, Vikram Patel, Vishal Patel, Warona Mathuba, Xian Yu, Yadira Leon, Yesenya Gonzalez, Yousef Rafati, Zachary Kadow, Zachary Simpson, Zahra Majd, Zane Shah, Zeena Nawas, and Zhining Ou

Subjects
Public aspects of medicine, RA1-1270
Abstract

The fifth annual summer research summit organized by the Center of Excellence (COE) in Health Equity, Training and Research, Baylor College of Medicine (BCM), was held on May 17, 2022. The theme of this year’s summit was ‘Academic-Community Partnerships: Change Agents for Advancing Health Equity.’ Given the ongoing pandemic, the summit was conducted virtually through digital platforms. This program was intended for both BCM and external audiences interested in advancing health equity, diversity, and inclusion in healthcare among healthcare providers and trainees, biomedical scientists, social workers, nurses, and individuals involved in talent acquisition and development, such as hiring managers (HR professionals), supervisors, college and hospital affiliate leadership and administrators, as well as diversity and inclusion excellence practitioners. We had attendees from all regions of the United States as well as from Saudi Arabia. The content in this Book of Abstracts encapsulates a summary of the research efforts by the BCM COE scholars (which includes post-baccalaureate students, medical students, clinical fellows, and junior faculty from BCM) as well as the external summit participants. The range of topics in this year’s summit was quite diverse, encompassing disparities in relation to maternal and child health (MCH), immigrant health, cancers, vaccination uptakes, and COVID-19 infections. Various solutions were ardently presented to address these disparities, including community engagement and partnerships, improvement in health literacy, and the development of novel technologies and therapeutics. With this summit, BCM continues to build on its long history of educational outreach initiatives to promote diversity in medicine by focusing on programs aimed at increasing the number of diverse and highly qualified medical professionals ready to introduce effective and innovative approaches to reduce or eliminate health disparities. These programs will improve information resources, clinical education, curricula, research, and cultural competence as they relate to minority health issues and social determinants of health. The year’s summit was a great success! Copyright © 2022 Dongarwar et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

Published
2022
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2. Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC)

Author

Courtney D. DiNardo, Sarah A. Bannon, Lucy A. Godley, Hannah Cheung, Jane E. Churpek, Maureen E. Mork, Koichi Takahashi, Anna Franklin, Jordan S. Orange, Andrew Futreal, Meselle Jeff-Eke, Alison A. Bertuch, Guillermo Garcia-Manero, Mark J. Routbort, Keyur P. Patel, Jeffrey L. Jorgensen, Mary Armanios, Emily M. Mace, Steve Kornblau, and Kapil N. Bhalla

Subjects
Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Adolescent, Patients, Platelet disorder, Genetic counseling, Genetic Counseling, Malignancy, Article, Workflow, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Fanconi anemia, Neoplastic Syndromes, Hereditary, Internal medicine, medicine, Biomarkers, Tumor, Humans, Family, Genetic Predisposition to Disease, Family history, Referral and Consultation, Germ-Line Mutation, Genetic testing, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Bone marrow failure, High-Throughput Nucleotide Sequencing, Hematology, Middle Aged, medicine.disease, Texas, Pedigree, 030220 oncology & carcinogenesis, Hematologic Neoplasms, Immunology, Female, business, Dyskeratosis congenita, 030215 immunology
Abstract

Introduction Although multiple predispositions to hematologic malignancies exist, evaluations for hereditary cancer syndromes (HCS) are underperformed by most hematologist/oncologists. Criteria for initiating HCS evaluation are poorly defined, and results of genetic testing for hereditary hematologic malignancies have not been systematically reported. Patients and Methods From April 2014 to August 2015, 67 patients were referred to the Hereditary Hematologic Malignancy Clinic (HHMC). Referral reasons included (1) bone marrow failure or myelodysplastic syndrome in patients ≤ 50 years, (2) evaluation for germ-line inheritance of identified RUNX1 , GATA2 , or CEBPA mutations on targeted next-generation sequencing panels, and (3) strong personal and/or family history of malignancy. Cultured skin fibroblasts were utilized for germ-line DNA in all patients with hematologic malignancy. Results Eight patients (12%) were clinically diagnosed with a HCS: 4 patients with RUNX1 -related familial platelet disorder (FPD)/acute myeloid leukemia (AML), and 1 patient each with dyskeratosis congenita, Fanconi anemia, germ-line DDX41 , and Li-Fraumeni syndrome (LFS). Two patients with concern for FPD/AML and LFS, respectively, had RUNX1 and TP53 variants of unknown significance. Additionally, 4 patients with prior HCS diagnosis (1 LFS, 3 FPD/AML) were referred for further evaluation and surveillance. Conclusion In this HHMC-referred hematologic malignancy cohort, HCS was confirmed in 12 patients (18%). HCS identification provides insight for improved and individualized treatment, as well as screening/surveillance opportunities for family members. The HHMC has facilitated HCS diagnosis; with increased clinical awareness of hematologic malignancy predisposition syndromes, more patients who may benefit from evaluation can be identified. Mutation panels intended for prognostication may provide increased clinical suspicion for germ-line testing.

Published
2016

3. New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine

Author

Lucy A. Godley, Meselle Jeff-Eke, Edward Litwin, John N. Nikitas, Christopher J. Mariani, Erika L. Moen, and Hayley Zullow

Subjects
Immunology, Computational biology, Ascorbic Acid, Biology, Article, chemistry.chemical_compound, Cytosine, Structure-Activity Relationship, Folic Acid, microRNA, Transcriptional regulation, Immunology and Allergy, Animals, Humans, Epigenetics, Enhancer, Promoter Regions, Genetic, Gene, 5-Hydroxymethylcytosine, Genetics, Promoter, DNA Methylation, Diet, DNA binding site, MicroRNAs, chemistry, Hematologic Neoplasms, 5-Methylcytosine, Transcription Factors
Abstract

5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) play a critical role in development and normal physiology. Alterations in 5-mC and 5-hmC patterns are common events in hematopoietic neoplasms. In this review, we begin by emphasizing the importance of 5-mC, 5-hmC, and their enzymatic modifiers in hematological malignancies. Then, we discuss the functions of 5-mC and 5-hmC at distinct genic contexts, including promoter regions, gene bodies, intron-exon boundaries, alternative promoters, and intragenic microRNAs. Recent advances in technology have allowed for the study of 5-mC and 5-hmC independently and specifically permitting distinction between the bases that show them to have transcriptional effects that vary by their location relative to gene structure. We extend these observations to their functions at enhancers and transcription factor binding sites. We discuss dietary influences on 5-mC and 5-hmC levels and summarize the literature on the effects of folate and vitamin C on 5-mC and 5-hmC, respectively. Finally, we discuss how these new themes in the functions of 5-mC and 5-hmC will likely influence the broader research field of epigenetics.

Published
2014

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